"Proteins Unique Sequence ID" "Checked" "Protein FDR Confidence: Combined" "Master" "Accession" "Description" "Exp. q-value: Combined" "Contaminant" "Sum PEP Score" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "Reactome Pathways" "WikiPathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundance Ratio: (127N, 37C) / (126, 37C)" "Abundance Ratio: (127C, 37C) / (126, 37C)" "Abundance Ratio: (128N, 37C) / (126, 37C)" "Abundance Ratio: (128C, 37C) / (126, 37C)" "Abundance Ratio: (129N, 37C) / (126, 37C)" "Abundance Ratio: (129C, 37C) / (126, 37C)" "Abundance Ratio: (130N, 37C) / (126, 37C)" "Abundance Ratio: (130C, 37C) / (126, 37C)" "Abundance Ratio: (131, 37C) / (126, 37C)" "Abundances (Grouped): 126, 37C" "Abundances (Grouped): 127N, 37C" "Abundances (Grouped): 127C, 37C" "Abundances (Grouped): 128N, 37C" "Abundances (Grouped): 128C, 37C" "Abundances (Grouped): 129N, 37C" "Abundances (Grouped): 129C, 37C" "Abundances (Grouped): 130N, 37C" "Abundances (Grouped): 130C, 37C" "Abundances (Grouped): 131, 37C" "Abundances (Grouped) CV [%]: 126, 37C" "Abundances (Grouped) CV [%]: 127N, 37C" "Abundances (Grouped) CV [%]: 127C, 37C" "Abundances (Grouped) CV [%]: 128N, 37C" "Abundances (Grouped) CV [%]: 128C, 37C" "Abundances (Grouped) CV [%]: 129N, 37C" "Abundances (Grouped) CV [%]: 129C, 37C" "Abundances (Grouped) CV [%]: 130N, 37C" "Abundances (Grouped) CV [%]: 130C, 37C" "Abundances (Grouped) CV [%]: 131, 37C" "Abundance: F46: 126, Sample, 37C" "Abundance: F46: 127N, Sample, 37C" "Abundance: F46: 127C, Sample, 37C" "Abundance: F46: 128N, Sample, 37C" "Abundance: F46: 128C, Sample, 37C" "Abundance: F46: 129N, Sample, 37C" "Abundance: F46: 129C, Sample, 37C" "Abundance: F46: 130N, Sample, 37C" "Abundance: F46: 130C, Sample, 37C" "Abundance: F46: 131, Sample, 37C" "Abundances Count: F46: 126, Sample, 37C" "Abundances Count: F46: 127N, Sample, 37C" "Abundances Count: F46: 127C, Sample, 37C" "Abundances Count: F46: 128N, Sample, 37C" "Abundances Count: F46: 128C, Sample, 37C" "Abundances Count: F46: 129N, Sample, 37C" "Abundances Count: F46: 129C, Sample, 37C" "Abundances Count: F46: 130N, Sample, 37C" "Abundances Count: F46: 130C, Sample, 37C" "Abundances Count: F46: 131, Sample, 37C" "Found in Sample: [S421] F46: 126, Sample, 37C" "Found in Sample: [S422] F46: 127N, Sample, 37C" "Found in Sample: [S423] F46: 127C, Sample, 37C" "Found in Sample: [S424] F46: 128N, Sample, 37C" "Found in Sample: [S425] F46: 128C, Sample, 37C" "Found in Sample: [S426] F46: 129N, Sample, 37C" "Found in Sample: [S427] F46: 129C, Sample, 37C" "Found in Sample: [S428] F46: 130N, Sample, 37C" "Found in Sample: [S429] F46: 130C, Sample, 37C" "Found in Sample: [S430] F46: 131, Sample, 37C" "# Protein Groups" "Modifications" "5927523368410573672" "False" "High" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "0.000" "False" "1190.664" "42" "154" "402" "154" "4128" "468.8" "7.12" "1344.31" "154" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "13" "0" "0.999" "1.025" "0.987" "0.997" "1.000" "0.987" "1.001" "0.974" "0.997" "33104.6" "33070.1" "33939.9" "32659.5" "33016.2" "33089.8" "32671.7" "33144.4" "32255.3" "32990.8" "" "" "" "" "" "" "" "" "" "" "26589.3" "23862.5" "26959.5" "21881.9" "22834.3" "24826.7" "22875.0" "24205.4" "32255.3" "26829.3" "134" "134" "134" "134" "134" "134" "134" "134" "134" "134" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305783293341844831" "False" "High" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "0.000" "False" "1087.211" "43" "178" "321" "178" "4646" "532.1" "6.40" "1084.69" "178" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Neutrophil degranulation; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; PAFAH1B1 copy number variation" "24" "0" "1.010" "0.996" "1.014" "1.008" "0.996" "1.009" "1.001" "1.002" "1.004" "26885.6" "27147.8" "26770.6" "27257.9" "27112.9" "26776.4" "27125.8" "26922.8" "26928.1" "26987.6" "" "" "" "" "" "" "" "" "" "" "21594.2" "19589.1" "21264.8" "18262.8" "18751.5" "20089.9" "18992.0" "19661.8" "26928.1" "21947.2" "133" "133" "133" "133" "133" "133" "133" "133" "133" "133" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2962281166201317424" "False" "High" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "0.000" "False" "1051.234" "53" "105" "443" "80" "1960" "226.4" "5.60" "1557.21" "105" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "EPHA-mediated growth cone collapse; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome; HDAC6 interactions in the central nervous system" "17" "27" "0.913" "0.985" "1.034" "1.031" "1.010" "1.056" "1.013" "1.054" "1.000" "33004.1" "30130.6" "32513.6" "34112.1" "34031.5" "33319.0" "34851.3" "33445.5" "34784.9" "33016.3" "" "" "" "" "" "" "" "" "" "" "26508.6" "21741.4" "25826.6" "22855.1" "23536.4" "24998.7" "24401.0" "24425.4" "34784.9" "26850.0" "100" "100" "100" "100" "100" "100" "100" "100" "100" "100" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241887692250600056" "False" "High" "IsMasterProtein" "Q15149" "Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3" "0.000" "False" "1015.137" "41" "176" "247" "175" "4684" "531.5" "5.96" "871.88" "176" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00681, Pf03501, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "5339" "ENSG00000178209" "PLEC" "hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383" "Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly" "Envelope proteins and their potential roles in EDMD physiopathology" "4" "1" "1.024" "0.995" "1.066" "1.059" "1.031" "1.145" "1.101" "1.096" "1.051" "15339.0" "15711.8" "15259.2" "16346.6" "16246.2" "15809.4" "17568.2" "16883.6" "16805.2" "16123.4" "" "" "" "" "" "" "" "" "" "" "12320.1" "11337.2" "12120.9" "10952.2" "11236.0" "11861.5" "12300.3" "12330.1" "16805.2" "13112.1" "113" "113" "113" "113" "113" "113" "113" "113" "113" "113" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4615289327887409645" "False" "High" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "0.000" "False" "863.422" "54" "106" "239" "93" "2541" "269.6" "6.07" "840.98" "106" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511, Pf21692" "7094" "ENSG00000137076" "TLN1" "A0A1S5UZ07; A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Platelet degranulation ; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "18" "10" "0.990" "0.965" "0.983" "0.981" "0.974" "0.995" "0.982" "0.992" "0.974" "17968.6" "17780.2" "17339.4" "17670.9" "17622.5" "17497.3" "17886.1" "17644.1" "17830.4" "17496.2" "" "" "" "" "" "" "" "" "" "" "14432.2" "12829.7" "13773.3" "11839.5" "12187.9" "13127.9" "12522.9" "12885.5" "17830.4" "14228.5" "84" "84" "84" "84" "84" "84" "84" "84" "84" "84" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6252367434931231115" "False" "High" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "0.000" "False" "836.820" "46" "91" "264" "90" "2511" "273.3" "6.44" "977.97" "91" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf16197, Pf21089, Pf21149" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "18" "1" "0.998" "1.008" "1.007" "0.990" "0.972" "1.027" "1.027" "1.016" "0.997" "20528.9" "20479.5" "20688.0" "20667.9" "20317.0" "19950.5" "21076.1" "21082.5" "20848.8" "20457.6" "" "" "" "" "" "" "" "" "" "" "16488.6" "14777.4" "16433.1" "13847.5" "14051.4" "14968.5" "14756.4" "15396.6" "20848.8" "16636.9" "80" "80" "80" "80" "80" "80" "80" "80" "80" "80" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4769002131436570839" "False" "High" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "0.000" "False" "552.594" "49" "64" "165" "64" "1675" "191.5" "5.69" "587.19" "64" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "25" "0" "0.938" "0.967" "1.023" "1.054" "1.061" "1.105" "1.057" "1.027" "1.012" "11735.7" "11003.5" "11344.5" "12000.1" "12369.7" "12449.6" "12968.6" "12409.9" "12057.8" "11876.3" "" "" "" "" "" "" "" "" "" "" "9426.0" "7939.8" "9011.3" "8040.1" "8555.0" "9340.7" "9079.9" "9063.0" "12057.8" "9658.2" "53" "53" "53" "53" "53" "53" "53" "53" "53" "53" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7449371538365957033" "False" "High" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "0.000" "False" "528.527" "39" "82" "149" "81" "2363" "267.1" "5.02" "513.33" "82" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "" "29" "1" "1.014" "0.953" "0.993" "0.989" "0.992" "0.982" "1.008" "1.038" "0.980" "14523.4" "14723.1" "13839.6" "14426.6" "14367.4" "14403.7" "14259.5" "14635.3" "15074.4" "14235.7" "" "" "" "" "" "" "" "" "" "" "11665.0" "10623.8" "10993.2" "9665.8" "9936.6" "10806.8" "9983.7" "10688.2" "15074.4" "11577.0" "66" "66" "66" "66" "66" "66" "66" "66" "66" "66" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5864065326781896084" "False" "High" "IsMasterProtein" "P27708" "Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "0.000" "False" "528.513" "38" "64" "147" "64" "2225" "242.8" "6.46" "541.86" "64" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Pyrimidine biosynthesis" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "4" "0" "1.026" "1.038" "1.037" "1.020" "1.036" "1.002" "0.980" "1.002" "1.020" "9904.8" "10165.9" "10284.6" "10269.5" "10100.3" "10256.6" "9928.6" "9704.8" "9924.3" "10107.7" "" "" "" "" "" "" "" "" "" "" "7955.5" "7335.4" "8169.4" "6880.5" "6985.5" "7695.3" "6951.5" "7087.4" "9924.3" "8219.9" "58" "58" "58" "58" "58" "58" "58" "58" "58" "58" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642176776796334220" "False" "High" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "0.000" "False" "508.245" "39" "69" "153" "50" "1976" "228.9" "5.54" "533.04" "69" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "EPHA-mediated growth cone collapse; RHO GTPases activate PAKs; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs" "Regulation of actin cytoskeleton" "7" "1" "0.890" "0.946" "1.085" "1.089" "1.084" "1.239" "1.102" "1.120" "1.052" "6737.5" "5999.0" "6373.4" "7309.7" "7337.0" "7303.1" "8348.0" "7421.5" "7546.4" "7088.3" "" "" "" "" "" "" "" "" "" "" "5411.5" "4328.7" "5062.6" "4897.5" "5074.3" "5479.4" "5844.8" "5420.0" "7546.4" "5764.4" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2327422208095163378" "False" "High" "IsMasterProtein" "P35749" "Myosin-11 OS=Homo sapiens OX=9606 GN=MYH11 PE=1 SV=3" "0.000" "False" "493.760" "39" "69" "150" "49" "1972" "227.2" "5.50" "522.60" "69" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4629" "ENSG00000133392; ENSG00000276480" "MYH11" "D2JYH7; hsa:4629; O00396; O94944; P35749; P78422; Q3MIV8; Q3MNF0; Q3MNF1" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "VEGFA-VEGFR2 signaling" "8" "2" "0.944" "0.959" "1.022" "1.014" "0.953" "0.994" "0.966" "0.960" "0.980" "5969.8" "5632.5" "5725.1" "6100.2" "6051.6" "5689.1" "5933.8" "5764.3" "5729.9" "5853.0" "" "" "" "" "" "" "" "" "" "" "4794.9" "4064.3" "4547.6" "4087.1" "4185.3" "4268.5" "4154.5" "4209.7" "5729.9" "4759.9" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7834140751544997544" "False" "High" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "0.000" "False" "487.242" "23" "85" "136" "85" "4374" "481.6" "5.22" "458.14" "85" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "" "2" "0" "1.013" "1.002" "1.035" "1.002" "0.998" "1.015" "0.992" "0.994" "1.010" "6736.2" "6822.5" "6748.3" "6969.5" "6752.9" "6723.3" "6838.7" "6684.3" "6694.8" "6804.9" "" "" "" "" "" "" "" "" "" "" "5410.4" "4922.9" "5360.4" "4669.6" "4670.4" "5044.4" "4788.1" "4881.5" "6694.8" "5534.0" "52" "52" "52" "52" "52" "52" "52" "52" "52" "52" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7065009906831580898" "False" "High" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "0.000" "False" "485.114" "61" "50" "447" "29" "732" "84.6" "5.02" "1397.07" "50" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Neutrophil degranulation; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced AP-1 survival signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway; HDAC6 interactions in the central nervous system" "71" "17" "0.997" "1.030" "0.975" "1.009" "1.021" "1.001" "1.013" "1.036" "1.007" "32231.4" "32119.1" "33205.5" "31414.0" "32534.8" "32894.8" "32253.5" "32640.4" "33404.7" "32447.7" "" "" "" "" "" "" "" "" "" "" "25887.9" "23176.2" "26376.2" "21047.4" "22501.4" "24680.4" "22582.2" "23837.4" "33404.7" "26387.6" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7017874985935534894" "False" "High" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "0.000" "False" "484.757" "62" "63" "161" "63" "1134" "123.7" "5.66" "515.97" "63" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Platelet degranulation ; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "18" "0" "0.973" "0.987" "0.987" "0.963" "0.960" "0.974" "0.945" "0.984" "0.962" "13965.3" "13587.6" "13780.0" "13782.5" "13451.1" "13409.0" "13606.3" "13199.1" "13746.8" "13433.8" "" "" "" "" "" "" "" "" "" "" "11216.8" "9804.4" "10945.9" "9234.3" "9302.9" "10060.5" "9526.4" "9639.4" "13746.8" "10924.9" "53" "53" "53" "53" "53" "53" "53" "53" "53" "53" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2220837361715177214" "False" "High" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "0.000" "False" "482.954" "62" "48" "535" "18" "724" "83.2" "5.03" "1707.13" "48" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Neutrophil degranulation; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "25" "12" "1.001" "1.009" "0.994" "1.010" "0.993" "1.016" "1.011" "1.033" "1.019" "19770.3" "19796.8" "19948.9" "19655.6" "19963.5" "19627.4" "20092.4" "19990.3" "20426.0" "20151.1" "" "" "" "" "" "" "" "" "" "" "15879.3" "14284.8" "15846.0" "13169.2" "13806.9" "14726.1" "14067.6" "14599.0" "20426.0" "16387.6" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5005343800474254733" "False" "High" "IsMasterProtein" "P13796" "Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6" "0.000" "False" "468.373" "63" "37" "378" "29" "627" "70.2" "5.43" "1188.33" "37" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00036, Pf00307" "3936" "ENSG00000136167" "LCP1" "B2R613; B4DUA0; hsa:3936; P13796; Q5TBN4" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "8" "1.003" "1.003" "1.011" "1.029" "1.002" "1.015" "0.994" "1.066" "1.016" "25076.1" "25151.8" "25143.9" "25344.0" "25791.3" "25138.0" "25460.3" "24919.1" "26721.1" "25484.1" "" "" "" "" "" "" "" "" "" "" "20140.8" "18148.8" "19972.6" "16980.5" "17837.5" "18860.6" "17826.0" "18198.5" "26721.1" "20724.6" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453697574232543386" "False" "High" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "0.000" "False" "458.296" "61" "46" "127" "45" "911" "104.8" "5.44" "471.26" "46" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Platelet degranulation ; Nephrin family interactions" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "9" "1" "0.960" "0.992" "0.970" "1.014" "1.035" "1.048" "1.003" "1.044" "0.999" "10907.1" "10468.7" "10819.6" "10581.4" "11059.0" "11284.0" "11434.8" "10941.1" "11386.3" "10900.7" "" "" "" "" "" "" "" "" "" "" "8760.5" "7553.9" "8594.4" "7089.6" "7648.5" "8466.2" "8006.1" "7990.3" "11386.3" "8864.8" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705476780399299386" "False" "High" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "0.000" "False" "456.091" "45" "58" "114" "58" "1657" "189.1" "6.48" "409.57" "58" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "25" "0" "0.992" "0.993" "0.971" "0.968" "0.958" "0.993" "1.015" "1.007" "0.985" "10903.9" "10820.3" "10832.9" "10583.8" "10558.4" "10445.8" "10823.6" "11065.5" "10981.1" "10740.9" "" "" "" "" "" "" "" "" "" "" "8757.9" "7807.6" "8604.9" "7091.1" "7302.3" "7837.3" "7578.1" "8081.2" "10981.1" "8734.9" "50" "50" "50" "50" "50" "50" "50" "50" "50" "50" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-613397371873318473" "False" "High" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "0.000" "False" "455.644" "61" "45" "162" "42" "840" "94.3" "5.19" "561.01" "45" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Regulation of HSF1-mediated heat shock response" "Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "3" "3" "0.978" "1.008" "0.975" "0.987" "1.001" "0.996" "0.972" "1.002" "0.987" "15266.5" "14937.8" "15384.2" "14883.9" "15070.7" "15278.3" "15204.9" "14845.2" "15299.2" "15063.7" "" "" "" "" "" "" "" "" "" "" "12261.9" "10778.7" "12220.2" "9972.2" "10423.0" "11463.1" "10645.7" "10841.5" "15299.2" "12250.3" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-174490317750568225" "False" "High" "IsMasterProtein" "Cont_P60712" "Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1" "0.000" "True" "450.074" "74" "26" "866" "9" "375" "41.7" "5.48" "2779.65" "26" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100011313; 100011351; 100033878; 100078865; 100135470; 100173832; 100303677; 100654618; 100689477; 100919051; 101026869; 101098507; 101375328; 101813373; 101844587; 101941176; 101958638; 102030392; 102041442; 102067189; 102179831; 102286048; 102386754; 102744309; 102772396; 102884469; 103050159; 103077223; 103115297; 103197222; 105077471; 105294565; 105497365; 105551087; 105719490; 105868294; 105990935; 106497948; 107155983; 107515934; 108496585; 108538237; 109314696; 109380220; 109700700; 11461; 280979; 396526; 403580; 414396; 443052; 450133; 574285; 60; 81822" "ENSABRG00000002004; ENSACOG00000001373; ENSACUG00000014525; ENSAMEG00000019137; ENSAMEG00000025519; ENSAMEG00000030859; ENSANAG00000024575; ENSAPLG00020013590; ENSBIXG00000014387; ENSBIXG00005017151; ENSBJAG00000012824; ENSBOBG00000008860; ENSBTAG00000026199; ENSCABG00000005869; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCAFG00805000771; ENSCCEG00000022540; ENSCCNG00000030119; ENSCGRG00001015781; ENSCHIG00000013316; ENSCJAG00000074750; ENSCJAG00000083114; ENSCLAG00000013196; ENSCMUG00000004054; ENSCPBG00000020809; ENSCPGG00000001752; ENSCPOG00000013467; ENSCPRG00005016203; ENSCPVG00000014059; ENSCSRG00000014125; ENSCUSG00005013766; ENSDLEG00000020930; ENSFALG00000013828; ENSFCAG00000006788; ENSFTIG00000005623; ENSG00000075624; ENSGAGG00000004381; ENSGEVG00005007981; ENSGGOG00000001133; ENSJHYG00000006128; ENSJJAG00000018929; ENSLCNG00005020599; ENSMCSG00000014736; ENSMICG00000002791; ENSMLEG00000038914; ENSMMMG00000007553; ENSMMNG00015004465; ENSMMSG00000018023; ENSMMUG00000011153; ENSMNEG00000033949; ENSMODG00000002647; ENSMPUG00000016612; ENSMUGG00000013478; ENSMUNG00000007311; ENSMUSG00000029580; ENSNVIG00000005620; ENSOANG00000007716; ENSOARG00020008714; ENSOSUG00000006211; ENSPANG00000015700; ENSPCEG00000013440; ENSPCLG00000014414; ENSPCTG00005017252; ENSPEMG00000012952; ENSPLOG00000015512; ENSPPYG00000017336; ENSPSTG00000003558; ENSPTEG00000021167; ENSPTRG00000018890; ENSPTXG00000006649; ENSRBIG00000014104; ENSRFEG00010011816; ENSRNOG00000034254; ENSRNOG00055011660; ENSRNOG00060020294; ENSRNOG00065000139; ENSSBOG00000033859; ENSSHAG00000029431; ENSSHBG00005009495; ENSSOCG00000011957; ENSSSCG00000007585; ENSSSCG00005020690; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSUG00005004355; ENSSTOG00000014797; ENSSVLG00005024720; ENSTGEG00000001941; ENSTMTG00000013939; ENSVKKG00000006783; ENSVURG00010018277; ENSZALG00000007655; ENSZLMG00000002642" "Actb; ACTB; Actb_0; ACTL8; LOC101872991; LOC106497948; LOC111145734; LOC112063645; LOC117800408; LOC118142876; PS1TP5BP1" "A0A096NAA6; A0A098M1X5; A0A0B6VJU7; A0A0B8RRU9; A0A0B8RTY2; A0A1D9CFN7; A0A1S2ZVA4; A0A1S3FRD3; A0A1U7Q273; A0A1W7RJQ3; A0A218UWT5; A0A226NJ42; A0A250YGN4; A0A2D4GG12; A0A2J8KJN5; A0A2J8RAH6; A0A2K5CXD5; A0A2K5ZNV7; A0A2K6C9L8; A0A2K6JVX9; A0A2K6UUH3; A0A2P4SFV3; A0A2U3VHD6; A0A2U3XSJ3; A0A2Y9GE45; A0A2Y9JFQ8; A0A2Y9MFS3; A0A2Y9S868; A0A340WEU6; A0A341CY14; A0A384AHN3; A0A3Q7NCZ0; A0A452EGB1; A0A452GTY2; A0A4D9ENE9; A0A4W2DYQ2; A0A4X2LSI7; A0A5E4C6E9; A0A5J5MXV1; A0A5N3VUL9; A0A5N4CXK3; A0A663NBJ0; A0A667IZV1; A0A669QC85; A0A670YBF6; A0A671EW41; A0A672U7D6; A0A673TCM5; A0A674JEF6; A0A6B0SBF2; A0A6B2F1I3; A0A6B2FBI6; A0A6I9HGD1; A0A6J0H3K7; A0A6J0VYA4; A0A6J1Y0U5; A0A6J2ER79; A0A6J2G0V3; A0A6J2MYQ0; A0A6J3AFQ7; A0A6J3DTG2; A0A6J3GBY8; A0A6J3PXY9; A0A6P3QDF4; A0A6P5M7F0; A0A6P5PSI5; A0A6P9D9Q3; A0A7J7X8Z4; A0A7J8FJ79; A0A7J8I7K0; A0A7K4LHI1; A0A7K4PGF5; A0A7K4QS53; A0A7K4T128; A0A7K4TT29; A0A7K4VIP3; A0A7K4WM66; A0A7K4XNG5; A0A7K4Z9S9; A0A7K5AA34; A0A7K5AS89; A0A7K5BQ55; A0A7K5FSS5; A0A7K5H4P8; A0A7K5I2U8; A0A7K5K1W1; A0A7K5L347; A0A7K5MV66; A0A7K5NYG3; A0A7K5PUR4; A0A7K5QKD4; A0A7K5SEW2; A0A7K5SN56; A0A7K5UCA8; A0A7K5V0T3; A0A7K5W0A4; A0A7K5XZZ2; A0A7K5YRX7; A0A7K5ZQ33; A0A7K6AXY2; A0A7K6BYL2; A0A7K6FAZ8; A0A7K6H213; A0A7K6K8T2; A0A7K6M1I6; A0A7K6NUL4; A0A7K6QDF5; A0A7K6RH22; A0A7K6TM80; A0A7K6VD36; A0A7K6W7N1; A0A7K6X5J8; A0A7K6YU38; A0A7K7C2G9; A0A7K7EJS7; A0A7K7FS46; A0A7K7GD18; A0A7K7IBW8; A0A7K7K4W1; A0A7K7KKG3; A0A7K7MQH8; A0A7K7MV68; A0A7K7PD37; A0A7K7QM76; A0A7K7SE36; A0A7K7SKG2; A0A7K7VCN0; A0A7K7W887; A0A7K7XYY4; A0A7K7YKB8; A0A7K8CFW2; A0A7K8EJC7; A0A7K8FS78; A0A7K8G222; A0A7K8IUQ2; A0A7K8JZV4; A0A7K8LPI3; A0A7K8NBM6; A0A7K8PNA5; A0A7K8Q6L8; A0A7K8RIG2; A0A7K8SZY6; A0A7K8UAQ8; A0A7K8VV48; A0A7K8WC57; A0A7K8XP00; A0A7K8YCU6; A0A7K9A6Q1; A0A7K9CAW4; A0A7K9CTY4; A0A7K9E1U2; A0A7K9FBL7; A0A7K9GU20; A0A7K9HIF7; A0A7K9J0P9; A0A7K9JQ87; A0A7K9LVG6; A0A7K9R4T1; A0A7K9RUC2; A0A7K9T1K6; A0A7K9TJU9; A0A7K9VM54; A0A7K9W8F9; A0A7K9XJP5; A0A7K9YTX8; A0A7L0B981; A0A7L0CFC2; A0A7L0DK08; A0A7L0EE55; A0A7L0FB96; A0A7L0GQU8; A0A7L0IUJ7; A0A7L0K254; A0A7L0L680; A0A7L0MVK5; A0A7L0NBG6; A0A7L0Q6H1; A0A7L0RLK8; A0A7L0TBQ4; A0A7L0UF87; A0A7L0WJD4; A0A7L0ZXX6; A0A7L1D3E3; A0A7L1EEL1; A0A7L1EWI9; A0A7L1GDD0; A0A7L1I1H5; A0A7L1IUB6; A0A7L1K0S4; A0A7L1L6I1; A0A7L1MJS1; A0A7L1N7E9; A0A7L1QY43; A0A7L1R9N1; A0A7L1TFJ1; A0A7L1USL1; A0A7L1X2N1; A0A7L1YHH8; A0A7L1ZA36; A0A7L2AFK2; A0A7L2CBA6; A0A7L2DI04; A0A7L2E5K5; A0A7L2ETQ7; A0A7L2GZ90; A0A7L2HLP4; A0A7L2JI84; A0A7L2K9F9; A0A7L2LSR8; A0A7L2MKA1; A0A7L2NWG1; A0A7L2Q5Z6; A0A7L2TKF5; A0A7L2UQP2; A0A7L2WPM1; A0A7L3AB48; A0A7L3AEQ2; A0A7L3CBV1; A0A7L3GBT6; A0A7L3H4H6; A0A7L3I6Y5; A0A7L3KV16; A0A7L3L3C1; A0A7L3M5B9; A0A7L3NFE1; A0A7L3PPT4; A0A7L3QID2; A0A7L3RPI2; A0A7L3ST79; A0A7L3U378; A0A7L3VAR1; A0A7L3W396; A0A7L3X8C9; A0A7L3Z0M0; A0A7L4AJ46; A0A7L4BIP7; A0A7L4CC84; A0A7L4DQB0; A0A7L4EP40; A0A7L4HN55; A0A7L4J9W9; A0A7M4FIE6; A0A7N4PW14; A0A7T6ZK12; A0A811Z8F1; A0A850TFQ9; A0A850V5R2; A0A850W4N7; A0A850XKN3; A0A850YK23; A0A851A5U4; A0A851B4R4; A0A851CTC7; A0A851D320; A0A851E8C6; A0A851F1A8; A0A851JVZ7; A0A851K2P6; A0A851LU60; A0A851P5P0; A0A851R2P6; A0A851S6S6; A0A851T4V4; A0A851U0I3; A0A851VRP0; A0A851WCV5; A0A851Y321; A0A851Z9B4; A0A852A4Z3; A0A852AR86; A0A852BQ86; A0A852DLV7; A0A852E4W4; A0A852G2S2; A0A852L7H9; A0A852LWU6; A0A852MIU4; A0A852P924; A0A8B6ZZ93; A0A8B7FY80; A0A8B7JWS2; A0A8B7QXR8; A0A8B8VBY0; A0A8B9BC47; A0A8B9EY57; A0A8B9TCS0; A0A8C0BMH3; A0A8C0GIN8; A0A8C0IEG6; A0A8C0VMY6; A0A8C2VXZ2; A0A8C3I6V8; A0A8C3J5G4; A0A8C3QCS8; A0A8C3SWN5; A0A8C3V1H9; A0A8C4U9L8; A0A8C4W3F9; A0A8C5IQ83; A0A8C5L3Y8; A0A8C5UI70; A0A8C5Z473; A0A8C6AVT7; A0A8C6E309; A0A8C6J2B6; A0A8C7ELL8; A0A8C8AQ23; A0A8C8SAX1; A0A8C8TJI2; A0A8C9D802; A0A8C9EU06; A0A8C9HDT2; A0A8D0FEG6; A0A8D2DXS1; A0A8D2E312; A0A8D2J5F6; A0A8D2QDJ6; A0A8D2QMT1; A0A8I3W1I0; A0A8J4I2Z8; A0A8J4N6K5; A0A8J4NKS0; A0A8J4P196; A0A8J4U9Z8; A0A8K0BW04; A0A8K1GFZ5; A0A8M1G7Q7; A0A8S9EM85; A0A8V5H9G0; A0A973YLC1; A0A9F2R4N2; A0A9W2UUK2; A0A9W3F4H2; A0AA35L9Q0; A0AA40H6S4; A0AA40LS06; A5D961; A5PKA1; A6K1N6; aam:106497948; aful:116495117; aju:106984514; asn:102386754; B2RRX1; bacu:103015338; bom:102286048; bta:280979; ccan:109700700; cfa:403580; cfr:102514032; cpic:101941176; cpoc:100135470; cpoo:109314696; D5MU85; D7RIF5; dle:111170344; dord:105990935; ecb:100033878; elk:111145734; F6TIK4; F6UDX9; F7DIB7; fab:101813373; fca:101098507; G1MLH3; G3GVD0; G3QFP0; G8HY07; gfr:102041442; gga:396526; hai:109380220; hsa:60; I3MNL1; J3S3X5; J7H0T4; L5L2F8; L5LSF7; lav:100654618; lve:103077223; lww:102744309; M3WRZ7; M3YYU9; M7B7E7; maua:101844587; mcal:110295381; mcc:574285; mdo:100011313; mdo:100011351; mleu:105551087; mmu:11461; mmur:105868294; mni:105497365; mpuf:101686268; myd:102772396; nasi:112412020; nsu:110572001; O18840; oaa:100078865; oro:101375328; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pale:102884469; panu:101026869; pbi:103050159; pcad:112063645; pcw:110223114; pdic:114509151; pgut:117676791; pon:100173832; ptr:450133; pvp:105294565; Q11209; Q11211; Q1KLZ0; Q25PW9; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q58J72; Q5R1X3; Q5R582; Q5R6G0; Q5W9H6; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; R0LHA7; ray:107515934; rbb:108538237; rno:81822; S9YTS3; sbq:101037287; shr:100919051; ssc:414396; T1DP26; U3FXK3; U3KHC4; umr:103670086; V9P8F4; vpc:102534524; zab:102067189; zca:113932833" "EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; RHO GTPases activate IQGAPs; Cell-extracellular matrix interactions; MAP2K and MAPK activation; UCH proteinases; Clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases Activate Formins; RHOF GTPase cycle; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; UCH proteinases; RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; RHO GTPases Activate Formins; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Adherens junctions interactions; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; MAP2K and MAPK activation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; RHO GTPases activate IQGAPs; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; UCH proteinases; Adherens junctions interactions; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of annular gap junctions" "FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion" "157" "19" "0.984" "1.015" "1.014" "1.052" "1.070" "1.047" "0.990" "1.033" "1.046" "40234.2" "39599.4" "40827.8" "40817.4" "42346.3" "43062.4" "42144.0" "39816.3" "41560.3" "42083.4" "" "" "" "" "" "" "" "" "" "" "32315.7" "28573.8" "32430.8" "27347.7" "29287.1" "32309.0" "29507.0" "29078.0" "41560.3" "34223.7" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1039523901046503215" "False" "High" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "0.000" "False" "446.488" "56" "71" "155" "71" "1394" "157.8" "6.13" "499.80" "71" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial RNA degradation" "Ciliary landscape" "5" "0" "0.981" "1.002" "0.952" "0.946" "0.944" "0.927" "0.974" "0.946" "0.953" "13702.4" "13437.6" "13735.5" "13044.7" "12964.0" "12929.1" "12696.9" "13349.5" "12967.8" "13052.0" "" "" "" "" "" "" "" "" "" "" "11005.7" "9696.2" "10910.6" "8740.0" "8966.0" "9700.5" "8889.7" "9749.2" "12967.8" "10614.3" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6488855965708197639" "False" "High" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "0.000" "False" "436.257" "69" "34" "312" "34" "531" "57.9" "7.84" "1022.59" "34" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Neutrophil degranulation" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "10" "0" "0.974" "0.989" "0.995" "0.980" "0.975" "0.979" "0.935" "0.951" "0.977" "22580.1" "21993.3" "22325.0" "22464.0" "22135.6" "22008.8" "22100.3" "21105.0" "21477.2" "22060.2" "" "" "" "" "" "" "" "" "" "" "18136.1" "15869.7" "17733.4" "15050.9" "15309.2" "16512.8" "15473.5" "15413.1" "21477.2" "17940.2" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823981804521467878" "False" "High" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "0.000" "False" "434.054" "29" "69" "107" "69" "3256" "358.5" "9.45" "365.46" "69" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "" "Primary focal segmental glomerulosclerosis (FSGS)" "1" "0" "1.075" "1.145" "1.128" "1.146" "1.160" "1.246" "1.211" "1.170" "1.141" "8031.6" "8630.8" "9196.4" "9062.9" "9204.7" "9319.2" "10009.4" "9727.9" "9394.7" "9161.6" "" "" "" "" "" "" "" "" "" "" "6450.9" "6227.7" "7305.0" "6072.1" "6366.0" "6992.0" "7008.1" "7104.3" "9394.7" "7450.5" "54" "54" "54" "54" "54" "54" "54" "54" "54" "54" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752798674986433827" "False" "High" "IsMasterProtein" "Q5T4S7" "E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1" "0.000" "False" "433.281" "16" "79" "110" "79" "5183" "573.5" "6.04" "371.72" "79" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02207, Pf13764, Pf19423" "23352" "ENSG00000127481" "UBR4" "A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S7; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "" "2" "0" "0.998" "1.018" "1.010" "0.995" "0.989" "0.979" "0.994" "1.014" "1.011" "9093.4" "9073.4" "9261.3" "9185.1" "9051.4" "8994.4" "8903.1" "9039.9" "9219.1" "9194.7" "" "" "" "" "" "" "" "" "" "" "7303.7" "6547.1" "7356.5" "6154.0" "6260.0" "6748.3" "6233.5" "6601.9" "9219.1" "7477.5" "59" "59" "59" "59" "59" "59" "59" "59" "59" "59" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7303961078788059209" "False" "High" "IsMasterProtein" "P49792" "E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2" "0.000" "False" "429.896" "29" "78" "110" "58" "3224" "358.0" "6.20" "381.23" "78" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00160, Pf00638, Pf00641, Pf12185" "5903" "ENSG00000153201" "RANBP2" "hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7" "RHO GTPases Activate Formins; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; Separation of Sister Chromatids; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Rev-mediated nuclear export of HIV RNA; HCMV Late Events; Resolution of Sister Chromatid Cohesion; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Signaling by ALK fusions and activated point mutants" "" "35" "14" "1.015" "1.034" "1.044" "1.067" "1.060" "1.042" "1.173" "1.142" "1.068" "11157.6" "11324.4" "11539.5" "11646.1" "11899.8" "11829.9" "11623.5" "13084.8" "12739.8" "11921.7" "" "" "" "" "" "" "" "" "" "" "8961.7" "8171.4" "9166.2" "7802.9" "8230.0" "8875.8" "8138.2" "9555.9" "12739.8" "9695.1" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5926930809007955556" "False" "High" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "0.000" "False" "426.356" "60" "44" "160" "40" "858" "96.8" "5.39" "549.30" "44" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "" "2" "2" "0.960" "0.988" "0.957" "0.975" "0.977" "0.989" "0.990" "0.978" "0.977" "15395.1" "14776.1" "15205.2" "14735.1" "15016.0" "15034.4" "15221.6" "15243.9" "15057.0" "15034.4" "" "" "" "" "" "" "" "" "" "" "12365.2" "10662.0" "12078.0" "9872.5" "10385.2" "11280.0" "10657.4" "11132.6" "15057.0" "12226.5" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5866289401045489846" "False" "High" "IsMasterProtein" "Q92616" "Stalled ribosome sensor GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=7" "0.000" "False" "425.615" "31" "74" "132" "74" "2671" "292.5" "7.43" "424.14" "74" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "" "10985" "ENSG00000089154" "GCN1" "A8KAY1; hsa:10985; O95001; O95651; Q6P2S3; Q86X65; Q8N5I5; Q8WU80; Q92616; Q99736; Q9UE60" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "" "1" "0" "1.009" "0.993" "1.003" "0.993" "0.973" "0.983" "1.030" "1.004" "0.993" "10852.1" "10945.6" "10772.3" "10879.3" "10773.4" "10560.3" "10668.2" "11176.0" "10893.6" "10776.9" "" "" "" "" "" "" "" "" "" "" "8716.3" "7898.0" "8556.8" "7289.2" "7451.0" "7923.2" "7469.3" "8161.9" "10893.6" "8764.1" "54" "54" "54" "54" "54" "54" "54" "54" "54" "54" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3910954529377130988" "False" "High" "IsMasterProtein" "Q9UPN3" "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4" "0.000" "False" "417.790" "13" "82" "101" "79" "7388" "837.8" "5.39" "342.41" "82" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "23499" "ENSG00000127603" "MACF1" "B1ALC5; E9PJT0; hsa:23499; O75053; Q5VW20; Q8WXY1; Q8WXY2; Q96PK2; Q9H540; Q9UKP0; Q9ULG9; Q9UPN3" "" "Mesodermal commitment pathway; Mesodermal commitment pathway" "2" "1" "1.010" "0.998" "1.047" "1.014" "0.972" "0.971" "0.959" "0.984" "1.009" "6737.3" "6806.6" "6724.8" "7055.9" "6834.4" "6550.6" "6539.9" "6459.7" "6629.8" "6796.9" "" "" "" "" "" "" "" "" "" "" "5411.3" "4911.4" "5341.8" "4727.5" "4726.7" "4914.8" "4578.9" "4717.6" "6629.8" "5527.5" "50" "50" "50" "50" "50" "50" "50" "50" "50" "50" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015185769260426388" "False" "High" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "0.000" "False" "417.222" "49" "48" "165" "48" "1101" "120.8" "7.33" "563.90" "48" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "10" "0" "0.980" "1.010" "0.991" "0.993" "0.993" "1.006" "1.004" "1.006" "0.992" "13700.0" "13430.7" "13836.4" "13580.2" "13604.3" "13607.7" "13783.9" "13751.2" "13778.3" "13589.0" "" "" "" "" "" "" "" "" "" "" "11003.7" "9691.2" "10990.7" "9098.7" "9408.9" "10209.6" "9650.8" "10042.5" "13778.3" "11051.1" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6514754949609892250" "False" "High" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "0.000" "False" "410.188" "45" "54" "118" "53" "1217" "141.5" "7.18" "421.89" "54" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "15" "1" "1.009" "0.996" "0.981" "0.966" "0.954" "0.962" "1.003" "1.003" "0.974" "11625.8" "11729.1" "11573.6" "11408.2" "11229.9" "11093.3" "11189.1" "11662.8" "11662.5" "11325.0" "" "" "" "" "" "" "" "" "" "" "9337.7" "8463.4" "9193.3" "7643.5" "7766.7" "8323.1" "7834.0" "8517.3" "11662.5" "9209.9" "53" "53" "53" "53" "53" "53" "53" "53" "53" "53" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-772083225745130744" "False" "High" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "0.000" "False" "409.155" "68" "40" "365" "23" "646" "70.9" "5.52" "1170.52" "40" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; mRNA Splicing - Major Pathway; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase; Respiratory syncytial virus genome transcription" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system" "27" "16" "1.001" "1.020" "0.990" "1.027" "1.013" "1.030" "1.036" "1.075" "1.025" "28095.1" "28119.5" "28657.9" "27807.2" "28855.6" "28463.5" "28937.5" "29100.6" "30195.3" "28797.8" "" "" "" "" "" "" "" "" "" "" "22565.7" "20290.2" "22763.9" "18630.8" "19956.8" "21355.7" "20260.5" "21252.3" "30195.3" "23419.4" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819136565778515185" "False" "High" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "0.000" "False" "400.659" "57" "44" "246" "43" "858" "95.3" "6.83" "748.69" "44" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "9" "1" "0.999" "1.035" "1.008" "1.059" "1.050" "1.068" "1.047" "1.035" "1.031" "18973.9" "18959.6" "19634.0" "19119.6" "20090.7" "19929.3" "20264.0" "19867.2" "19634.9" "19563.6" "" "" "" "" "" "" "" "" "" "" "15239.6" "13680.7" "15595.9" "12810.2" "13894.9" "14952.6" "14187.8" "14509.1" "19634.9" "15909.8" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6896953880380314494" "False" "High" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "0.000" "False" "396.236" "61" "41" "140" "41" "806" "89.3" "5.26" "484.02" "41" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5; V9HW80" "ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; E3 ubiquitin ligases ubiquitinate target proteins; Aggrephagy; Neutrophil degranulation; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; RHOH GTPase cycle; HSF1 activation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism; HDAC6 interactions in the central nervous system" "21" "0" "0.975" "1.004" "0.991" "1.019" "0.987" "0.982" "0.977" "0.993" "0.988" "9620.8" "9382.1" "9655.1" "9536.2" "9799.2" "9494.5" "9443.1" "9402.5" "9557.3" "9503.8" "" "" "" "" "" "" "" "" "" "" "7727.3" "6769.9" "7669.3" "6389.2" "6777.2" "7123.5" "6611.6" "6866.7" "9557.3" "7728.9" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5619484675981056092" "False" "High" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "0.000" "False" "393.143" "72" "35" "205" "35" "573" "61.0" "5.87" "701.20" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Mitochondrial protein degradation; Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "6" "0" "0.992" "0.986" "0.962" "0.973" "0.932" "0.951" "0.970" "1.029" "0.961" "14065.0" "13958.8" "13873.9" "13537.0" "13680.6" "13108.5" "13381.3" "13648.9" "14472.5" "13523.1" "" "" "" "" "" "" "" "" "" "" "11296.8" "10072.3" "11020.5" "9069.8" "9461.6" "9835.1" "9368.9" "9967.9" "14472.5" "10997.5" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2426861074950700078" "False" "High" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "0.000" "False" "391.344" "48" "39" "144" "39" "1058" "117.8" "5.76" "479.41" "39" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "5" "0" "0.997" "0.980" "1.018" "1.007" "0.947" "0.983" "0.970" "0.947" "0.998" "10258.0" "10228.0" "10054.1" "10438.2" "10328.3" "9715.8" "10082.7" "9953.7" "9710.9" "10235.8" "" "" "" "" "" "" "" "" "" "" "8239.1" "7380.2" "7986.3" "6993.6" "7143.1" "7289.6" "7059.4" "7269.2" "9710.9" "8324.1" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3002712347046388220" "False" "High" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "0.000" "False" "390.185" "77" "33" "160" "33" "535" "57.5" "6.46" "523.16" "33" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "10" "0" "1.030" "1.038" "1.008" "1.042" "1.040" "1.011" "1.053" "1.012" "1.052" "9984.6" "10284.9" "10368.4" "10064.9" "10403.8" "10386.3" "10098.3" "10518.3" "10099.9" "10504.5" "" "" "" "" "" "" "" "" "" "" "8019.5" "7421.3" "8235.9" "6743.5" "7195.3" "7792.7" "7070.3" "7681.6" "10099.9" "8542.6" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1156142612126302656" "False" "High" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "0.000" "False" "388.050" "38" "49" "108" "48" "1512" "170.5" "7.33" "390.77" "49" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180, Pf20974" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "6" "1" "1.006" "1.005" "0.987" "0.969" "0.993" "0.969" "0.986" "1.011" "0.968" "11637.2" "11711.1" "11690.3" "11480.2" "11279.4" "11550.3" "11273.9" "11474.5" "11771.0" "11260.7" "" "" "" "" "" "" "" "" "" "" "9346.9" "8450.4" "9286.0" "7691.7" "7801.0" "8665.9" "7893.4" "8379.9" "11771.0" "9157.6" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-66753491464337277" "False" "High" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "0.000" "False" "379.636" "31" "70" "94" "70" "2472" "284.4" "5.35" "320.95" "70" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins" "Fas ligand pathway and stress induction of heat shock proteins" "12" "0" "0.982" "0.966" "0.967" "1.017" "0.970" "1.067" "1.017" "1.041" "1.000" "7304.2" "7171.2" "7053.7" "7065.1" "7431.5" "7088.1" "7794.6" "7428.1" "7607.1" "7304.7" "" "" "" "" "" "" "" "" "" "" "5866.6" "5174.5" "5602.9" "4733.6" "5139.7" "5318.1" "5457.4" "5424.8" "7607.1" "5940.5" "53" "53" "53" "53" "53" "53" "53" "53" "53" "53" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5561612098835552022" "False" "High" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "0.000" "False" "375.764" "59" "38" "142" "37" "679" "73.6" "6.16" "510.23" "38" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein degradation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "7" "0" "0.982" "0.991" "0.984" "1.021" "0.996" "1.014" "1.017" "1.062" "0.991" "11465.3" "11256.6" "11366.9" "11279.3" "11701.7" "11422.4" "11630.8" "11657.4" "12172.4" "11360.0" "" "" "" "" "" "" "" "" "" "" "9208.8" "8122.5" "9029.1" "7557.1" "8093.0" "8570.0" "8143.3" "8513.4" "12172.4" "9238.4" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6210925912035566058" "False" "High" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "0.000" "False" "371.285" "33" "58" "81" "58" "2115" "238.1" "5.78" "316.67" "58" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21670" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "5" "0" "1.000" "0.969" "1.035" "1.017" "1.021" "1.073" "1.144" "1.141" "1.061" "5468.1" "5468.1" "5298.8" "5657.0" "5559.5" "5583.1" "5868.8" "6256.6" "6241.3" "5802.4" "" "" "" "" "" "" "" "" "" "" "4392.0" "3945.6" "4209.0" "3790.2" "3845.0" "4188.9" "4109.0" "4569.2" "6241.3" "4718.7" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5089087001200962096" "False" "High" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0.000" "False" "368.412" "21" "44" "65" "44" "2813" "307.4" "5.24" "274.94" "44" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "8" "0" "1.049" "0.987" "1.031" "0.980" "0.963" "0.930" "0.973" "0.964" "0.976" "5833.6" "6120.5" "5755.4" "6013.9" "5717.4" "5619.7" "5425.5" "5674.5" "5620.7" "5692.9" "" "" "" "" "" "" "" "" "" "" "4685.4" "4416.4" "4571.7" "4029.3" "3954.2" "4216.3" "3798.7" "4144.1" "5620.7" "4629.7" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357852675593899782" "False" "High" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "0.000" "False" "365.595" "60" "44" "120" "44" "808" "90.9" "5.77" "408.42" "44" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "11" "0" "0.996" "1.036" "0.983" "0.987" "0.987" "0.978" "1.028" "1.038" "1.005" "10078.4" "10041.1" "10439.3" "9902.1" "9951.5" "9946.0" "9860.4" "10362.9" "10459.2" "10127.2" "" "" "" "" "" "" "" "" "" "" "8094.9" "7245.3" "8292.2" "6634.4" "6882.5" "7462.3" "6903.7" "7568.1" "10459.2" "8235.8" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "32097797701443302" "False" "High" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "0.000" "False" "355.761" "31" "57" "99" "57" "2032" "225.4" "7.80" "326.22" "57" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21041" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "4p16.3 copy number variation" "14" "0" "1.033" "0.997" "1.006" "0.994" "0.992" "0.999" "1.033" "1.020" "1.009" "8293.6" "8567.3" "8266.1" "8346.4" "8243.5" "8230.1" "8283.9" "8565.7" "8457.6" "8364.9" "" "" "" "" "" "" "" "" "" "" "6661.3" "6181.9" "6566.0" "5592.1" "5701.3" "6174.9" "5800.0" "6255.5" "8457.6" "6802.7" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1034815253104013464" "False" "High" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "0.000" "False" "353.969" "73" "35" "170" "35" "548" "59.6" "5.60" "562.71" "35" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261; ENSG00000291533" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "8" "0" "1.016" "1.035" "0.989" "1.003" "0.974" "0.961" "0.979" "1.005" "0.985" "15070.4" "15313.2" "15601.4" "14911.0" "15112.8" "14681.1" "14480.8" "14752.5" "15149.2" "14838.4" "" "" "" "" "" "" "" "" "" "" "12104.4" "11049.5" "12392.7" "9990.4" "10452.1" "11015.0" "10138.7" "10773.8" "15149.2" "12067.1" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5579729439990208910" "False" "High" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "0.000" "False" "352.057" "72" "28" "339" "13" "434" "47.1" "7.39" "1084.58" "28" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "9" "16" "1.018" "1.028" "0.986" "1.001" "1.004" "0.959" "0.940" "0.996" "0.978" "21268.9" "21651.1" "21857.4" "20972.3" "21290.8" "21357.4" "20398.1" "19991.7" "21192.5" "20805.4" "" "" "" "" "" "" "" "" "" "" "17082.9" "15622.8" "17362.0" "14051.4" "14724.9" "16024.1" "14281.7" "14600.0" "21192.5" "16919.6" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7448021442665095265" "False" "High" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "0.000" "False" "350.134" "44" "51" "102" "51" "1197" "135.6" "8.43" "379.32" "51" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "Retinoblastoma gene in cancer" "3" "0" "0.995" "1.000" "0.966" "0.966" "0.949" "0.969" "0.972" "0.977" "0.960" "11700.6" "11638.9" "11700.5" "11308.5" "11308.3" "11102.6" "11332.4" "11377.1" "11436.2" "11232.6" "" "" "" "" "" "" "" "" "" "" "9397.8" "8398.3" "9294.0" "7576.7" "7820.9" "8330.1" "7934.4" "8308.7" "11436.2" "9134.7" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-951770295276680131" "False" "High" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "0.000" "False" "348.891" "45" "48" "148" "48" "1014" "113.0" "8.88" "458.06" "48" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063, Pf21728" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map" "25" "0" "1.036" "1.096" "1.041" "1.021" "1.042" "1.066" "1.098" "1.068" "1.055" "13734.1" "14232.3" "15048.1" "14298.5" "14020.3" "14314.3" "14644.4" "15079.3" "14674.1" "14489.8" "" "" "" "" "" "" "" "" "" "" "11031.1" "10269.7" "11953.2" "9580.0" "9696.6" "10739.8" "10253.2" "11012.4" "14674.1" "11783.6" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3757999433169180156" "False" "High" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "0.000" "False" "348.843" "47" "53" "102" "53" "1288" "147.1" "6.79" "352.46" "53" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "Ciliary landscape" "3" "0" "1.030" "1.009" "1.012" "1.017" "1.018" "0.985" "1.001" "1.006" "1.018" "8608.9" "8863.8" "8684.4" "8710.4" "8758.5" "8762.9" "8479.6" "8617.5" "8664.1" "8761.7" "" "" "" "" "" "" "" "" "" "" "6914.6" "6395.8" "6898.3" "5835.9" "6057.5" "6574.7" "5937.0" "6293.4" "8664.1" "7125.3" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9133260577685858014" "False" "High" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "0.000" "False" "344.988" "49" "39" "107" "37" "1097" "123.6" "4.94" "356.21" "39" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "vRNP Assembly" "" "1" "2" "0.996" "0.971" "0.990" "0.963" "0.983" "0.952" "0.960" "0.959" "0.988" "8287.3" "8255.7" "8045.6" "8206.9" "7976.5" "8147.4" "7888.9" "7955.8" "7950.6" "8187.1" "" "" "" "" "" "" "" "" "" "" "6656.3" "5957.1" "6390.9" "5498.6" "5516.6" "6112.8" "5523.4" "5810.1" "7950.6" "6658.1" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1011353078992681906" "False" "High" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "0.000" "False" "342.020" "48" "34" "105" "34" "904" "101.8" "5.52" "378.90" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome" "11" "0" "0.980" "1.001" "0.965" "0.960" "0.960" "0.953" "0.984" "0.944" "0.973" "8602.6" "8432.6" "8608.0" "8300.4" "8254.6" "8259.2" "8194.2" "8464.3" "8125.2" "8370.2" "" "" "" "" "" "" "" "" "" "" "6909.5" "6084.7" "6837.6" "5561.3" "5708.9" "6196.7" "5737.1" "6181.5" "8125.2" "6806.9" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8277375164580502172" "False" "High" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "0.000" "False" "335.623" "48" "56" "114" "56" "1233" "143.1" "7.64" "371.12" "56" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "Estrogen-dependent gene expression; Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response" "22" "0" "1.017" "1.023" "1.001" "0.990" "0.988" "0.991" "1.035" "1.026" "1.002" "10876.8" "11066.3" "11128.5" "10883.5" "10767.6" "10746.7" "10774.6" "11260.6" "11163.9" "10903.6" "" "" "" "" "" "" "" "" "" "" "8736.1" "7985.1" "8839.7" "7291.9" "7447.0" "8063.1" "7543.8" "8223.6" "11163.9" "8867.2" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576515921520274560" "False" "High" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "0.000" "False" "332.515" "58" "35" "99" "35" "645" "72.9" "5.07" "350.25" "35" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "0" "0.963" "0.963" "0.954" "1.000" "0.985" "1.001" "1.021" "1.018" "0.984" "9349.8" "8999.9" "9006.5" "8918.8" "9347.9" "9210.0" "9359.8" "9545.0" "9519.9" "9204.3" "" "" "" "" "" "" "" "" "" "" "7509.6" "6494.1" "7154.1" "5975.6" "6465.1" "6910.1" "6553.3" "6970.7" "9519.9" "7485.3" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "682895518506643546" "False" "High" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "0.000" "False" "332.419" "54" "32" "139" "29" "654" "72.3" "5.16" "484.33" "32" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "14" "0" "0.981" "0.922" "1.069" "1.069" "0.971" "1.121" "1.101" "1.067" "1.007" "7020.6" "6888.6" "6476.3" "7502.6" "7503.3" "6818.8" "7872.5" "7732.1" "7492.5" "7070.7" "" "" "" "" "" "" "" "" "" "" "5638.9" "4970.6" "5144.3" "5026.7" "5189.4" "5116.0" "5511.9" "5646.8" "7492.5" "5750.1" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6942352143814958774" "False" "High" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "0.000" "False" "329.207" "64" "33" "158" "33" "545" "60.5" "6.49" "534.66" "33" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "1.013" "1.006" "1.013" "0.992" "0.984" "0.985" "0.997" "0.970" "0.979" "12749.5" "12920.4" "12829.0" "12919.3" "12648.5" "12548.1" "12559.6" "12711.1" "12361.1" "12480.8" "" "" "" "" "" "" "" "" "" "" "10240.3" "9323.0" "10190.4" "8656.0" "8747.8" "9414.6" "8793.6" "9283.0" "12361.1" "10149.8" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7742249596596208262" "False" "High" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "0.000" "False" "324.264" "54" "42" "98" "42" "910" "101.9" "7.17" "350.51" "42" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "Signaling by BRAF and RAF1 fusions" "VEGFA-VEGFR2 signaling" "2" "0" "0.987" "1.052" "1.019" "1.017" "1.023" "1.053" "1.001" "0.996" "0.975" "9917.9" "9792.8" "10428.9" "10109.4" "10088.4" "10147.1" "10446.6" "9930.0" "9876.0" "9670.5" "" "" "" "" "" "" "" "" "" "" "7966.0" "7066.2" "8284.0" "6773.3" "6977.2" "7613.2" "7314.2" "7251.9" "9876.0" "7864.4" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2890284807861643792" "False" "High" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "0.000" "False" "324.224" "45" "36" "94" "36" "1010" "107.7" "6.70" "339.29" "36" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Purine ribonucleoside monophosphate biosynthesis" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "4" "0" "0.977" "0.981" "1.006" "0.998" "0.976" "0.982" "0.978" "0.962" "1.005" "7802.1" "7622.3" "7653.6" "7848.8" "7787.2" "7612.0" "7663.5" "7632.1" "7503.8" "7838.5" "" "" "" "" "" "" "" "" "" "" "6266.6" "5500.0" "6079.5" "5258.7" "5385.7" "5711.2" "5365.6" "5573.8" "7503.8" "6374.5" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6866488294459179487" "False" "High" "IsMasterProtein" "Q8NFC6" "Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2" "0.000" "False" "322.016" "22" "57" "76" "55" "3051" "330.3" "5.08" "262.85" "57" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf05205" "259282" "ENSG00000038219" "BOD1L1" "hsa:259282; Q6P0M8; Q8NFC6; Q96AL1; Q9H6G0; Q9NTD6; Q9P2L9" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "0.996" "1.006" "0.958" "0.973" "1.004" "0.954" "0.938" "0.982" "0.985" "6243.1" "6218.7" "6281.3" "5981.9" "6075.2" "6266.5" "5958.2" "5857.0" "6131.9" "6147.9" "" "" "" "" "" "" "" "" "" "" "5014.4" "4487.3" "4989.4" "4007.9" "4201.7" "4701.7" "4171.6" "4277.4" "6131.9" "4999.7" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927890985374291245" "False" "High" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4" "0.000" "False" "320.135" "44" "38" "92" "37" "935" "101.5" "7.30" "337.18" "38" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "4522" "ENSG00000100714" "MTHFD1" "A0A024R652; A0A384N5Y3; B2R5Y2; G3V2B8; hsa:4522; P11586; Q86VC9; Q9BVP5" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Male infertility; Spina bifida" "6" "1" "0.976" "0.998" "0.996" "0.998" "0.953" "0.984" "1.002" "0.983" "0.976" "8157.3" "7960.5" "8139.3" "8128.1" "8144.8" "7771.7" "8030.3" "8170.3" "8016.9" "7962.6" "" "" "" "" "" "" "" "" "" "" "6551.8" "5744.1" "6465.3" "5445.9" "5633.0" "5830.9" "5622.4" "5966.8" "8016.9" "6475.5" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637669709604963095" "False" "High" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "0.000" "False" "319.842" "29" "42" "66" "42" "1972" "213.4" "4.70" "243.06" "42" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "ATM signaling pathway; ATM signaling in development and disease" "7" "0" "0.985" "0.974" "1.008" "0.983" "0.957" "0.991" "1.004" "1.009" "0.975" "5693.2" "5609.5" "5545.9" "5738.9" "5597.0" "5449.0" "5642.5" "5718.0" "5742.6" "5549.0" "" "" "" "" "" "" "" "" "" "" "4572.7" "4047.7" "4405.3" "3845.1" "3870.9" "4088.3" "3950.6" "4175.8" "5742.6" "4512.6" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4567547795878987385" "False" "High" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "0.000" "False" "317.888" "26" "50" "63" "44" "2647" "280.6" "6.06" "236.21" "50" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome" "14" "5" "0.980" "0.972" "0.993" "0.999" "0.996" "1.103" "1.069" "1.090" "1.032" "5188.4" "5087.2" "5042.4" "5152.6" "5184.5" "5168.6" "5723.9" "5546.4" "5652.9" "5356.4" "" "" "" "" "" "" "" "" "" "" "4167.2" "3670.8" "4005.4" "3452.2" "3585.7" "3877.9" "4007.6" "4050.5" "5652.9" "4356.0" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8533826193911874289" "False" "High" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "0.000" "False" "317.823" "42" "48" "134" "45" "1230" "136.3" "5.78" "430.76" "48" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623, Pf13513" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "Endoderm differentiation" "4" "1" "0.986" "1.028" "0.972" "0.965" "0.963" "0.976" "0.992" "0.971" "0.969" "11413.0" "11252.7" "11729.7" "11093.9" "11012.4" "10993.9" "11135.5" "11324.1" "11076.5" "11053.9" "" "" "" "" "" "" "" "" "" "" "9166.8" "8119.7" "9317.3" "7432.9" "7616.3" "8248.5" "7796.5" "8270.0" "11076.5" "8989.4" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707926075363841764" "False" "High" "IsMasterProtein" "Q99798" "Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2" "0.000" "False" "317.347" "51" "30" "97" "30" "780" "85.4" "7.61" "342.38" "30" "other metabolic processes;stress response;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00330, Pf00694" "50" "ENSG00000100412" "ACO2" "hsa:50; O75809; Q5JZ41; Q6FHX0; Q8TAQ6; Q99798" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.985" "0.977" "0.966" "0.968" "0.965" "0.927" "0.969" "0.928" "0.972" "8033.2" "7910.3" "7851.5" "7756.2" "7777.2" "7753.0" "7450.5" "7781.2" "7452.4" "7810.8" "" "" "" "" "" "" "" "" "" "" "6452.2" "5707.8" "6236.7" "5196.7" "5378.8" "5817.0" "5216.5" "5682.6" "7452.4" "6352.0" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3959572878681588940" "False" "High" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "0.000" "False" "316.656" "68" "30" "125" "30" "556" "60.3" "6.11" "427.55" "30" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "8" "0" "0.988" "1.045" "0.996" "1.015" "0.984" "0.998" "0.982" "0.955" "0.962" "10594.3" "10466.0" "11072.9" "10556.6" "10758.4" "10430.0" "10573.7" "10398.3" "10122.0" "10191.6" "" "" "" "" "" "" "" "" "" "" "8509.2" "7552.0" "8795.6" "7072.9" "7440.6" "7825.4" "7403.2" "7593.9" "10122.0" "8288.2" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9169618704545618170" "False" "High" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "0.000" "False" "316.180" "70" "26" "191" "3" "364" "39.4" "8.09" "672.79" "26" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; Platelet degranulation" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "22" "0.988" "0.996" "0.978" "1.015" "1.004" "0.993" "0.972" "1.011" "0.978" "13802.6" "13636.3" "13751.2" "13501.9" "14011.0" "13853.5" "13701.2" "13416.6" "13949.9" "13500.2" "" "" "" "" "" "" "" "" "" "" "11086.1" "9839.6" "10923.0" "9046.2" "9690.1" "10394.1" "9592.8" "9798.2" "13949.9" "10978.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054273267636823051" "False" "High" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "0.000" "False" "314.611" "39" "39" "95" "39" "1270" "140.9" "6.84" "337.60" "39" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "mRNA Splicing - Major Pathway; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "MECP2 and associated Rett syndrome; mRNA processing" "6" "0" "1.046" "1.093" "1.145" "1.188" "1.136" "1.174" "1.159" "1.167" "1.115" "5034.5" "5265.4" "5504.8" "5766.5" "5982.1" "5720.8" "5911.6" "5832.8" "5877.6" "5614.8" "" "" "" "" "" "" "" "" "" "" "4043.6" "3799.4" "4372.7" "3863.5" "4137.3" "4292.2" "4139.0" "4259.7" "5877.6" "4566.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8012908085941337264" "False" "High" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "0.000" "False" "311.383" "65" "29" "123" "29" "543" "59.3" "7.65" "417.86" "29" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "Formation of tubulin folding intermediates by CCT/TriC; RHOBTB1 GTPase cycle; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "9" "0" "0.997" "1.000" "0.963" "0.974" "0.948" "0.947" "0.962" "0.938" "0.965" "9224.0" "9199.0" "9223.9" "8879.5" "8979.6" "8746.0" "8737.8" "8873.1" "8651.2" "8905.4" "" "" "" "" "" "" "" "" "" "" "7408.6" "6637.8" "7326.8" "5949.2" "6210.4" "6562.0" "6117.8" "6480.0" "8651.2" "7242.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418914028943411131" "False" "High" "IsMasterProtein" "P29144" "Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4" "0.000" "False" "309.416" "40" "42" "94" "42" "1249" "138.3" "6.32" "323.28" "42" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00082, Pf12580, Pf12583, Pf21223, Pf21316" "7174" "ENSG00000134900" "TPP2" "hsa:7174; P29144; Q5VZU8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.989" "0.998" "0.984" "1.002" "1.002" "0.960" "0.941" "0.952" "0.971" "8290.4" "8195.6" "8275.7" "8154.2" "8309.4" "8305.1" "7958.8" "7803.3" "7889.7" "8052.7" "" "" "" "" "" "" "" "" "" "" "6658.8" "5913.7" "6573.6" "5463.3" "5746.8" "6231.2" "5572.3" "5698.8" "7889.7" "6548.7" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6880355764133463335" "False" "High" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "0.000" "False" "308.964" "36" "50" "98" "50" "1616" "183.1" "7.75" "336.87" "50" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; Nuclear events stimulated by ALK signaling in cancer" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Spina bifida" "13" "0" "1.003" "1.010" "0.966" "1.004" "1.001" "0.987" "1.009" "0.997" "0.985" "7860.3" "7885.0" "7936.1" "7590.1" "7894.1" "7869.5" "7761.8" "7932.3" "7836.5" "7742.2" "" "" "" "" "" "" "" "" "" "" "6313.3" "5689.6" "6303.9" "5085.3" "5459.6" "5904.3" "5434.4" "5792.9" "7836.5" "6296.2" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562319574892213792" "False" "High" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "0.000" "False" "306.841" "68" "23" "410" "23" "335" "36.0" "8.46" "1278.03" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Glycolysis; Gluconeogenesis" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "16" "0" "0.983" "1.008" "1.018" "1.023" "1.061" "1.015" "0.984" "0.986" "1.028" "25424.0" "24991.9" "25620.8" "25893.7" "26018.3" "26974.3" "25802.6" "25009.6" "25078.0" "26148.1" "" "" "" "" "" "" "" "" "" "" "20420.3" "18033.4" "20351.5" "17348.7" "17994.5" "20238.3" "18065.7" "18264.6" "25078.0" "21264.6" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3348063048302493190" "False" "High" "IsMasterProtein" "P50851" "Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4" "0.000" "False" "306.477" "22" "52" "73" "52" "2863" "318.9" "5.60" "256.48" "52" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "987" "ENSG00000198589" "LRBA" "hsa:987; P50851; Q4W5J4; Q4W5L6; Q8NFQ0; Q9H2U3; Q9H2U4" "" "" "0" "0" "1.067" "1.012" "1.060" "1.031" "1.041" "1.019" "1.069" "1.046" "1.021" "4284.4" "4570.9" "4335.5" "4541.3" "4417.4" "4459.4" "4367.8" "4578.2" "4481.2" "4375.7" "" "" "" "" "" "" "" "" "" "" "3441.2" "3298.2" "3443.8" "3042.7" "3055.1" "3345.8" "3058.1" "3343.5" "4481.2" "3558.5" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1119286615561917853" "False" "High" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "0.000" "False" "306.388" "74" "26" "169" "22" "417" "44.6" "8.10" "579.01" "26" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "13" "4" "0.997" "1.015" "0.983" "0.974" "0.992" "0.962" "0.925" "0.938" "0.969" "14274.6" "14234.1" "14482.8" "14029.3" "13899.5" "14159.0" "13731.3" "13206.5" "13387.3" "13831.4" "" "" "" "" "" "" "" "" "" "" "11465.2" "10270.9" "11504.1" "9399.6" "9613.0" "10623.3" "9613.9" "9644.7" "13387.3" "11248.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625337675714682058" "False" "High" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "0.000" "False" "306.299" "49" "41" "80" "33" "963" "109.6" "6.51" "283.49" "41" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; Insulin processing; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "11" "7" "0.989" "1.006" "0.990" "0.995" "0.986" "0.993" "0.983" "0.992" "0.993" "7991.7" "7903.5" "8043.2" "7912.7" "7953.6" "7882.6" "7935.8" "7853.5" "7924.0" "7936.1" "" "" "" "" "" "" "" "" "" "" "6418.8" "5703.0" "6388.9" "5301.5" "5500.7" "5914.2" "5556.3" "5735.4" "7924.0" "6454.0" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-806880739347862445" "False" "High" "IsMasterProtein" "Q71U36" "Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1" "0.000" "False" "304.124" "63" "24" "253" "2" "451" "50.1" "5.06" "868.21" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7846" "ENSG00000167552" "TUBA1A" "A8K0B8; G3V1U9; hsa:7846; P04687; P05209; Q71U36" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Recycling pathway of L1; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; PAFAH1B1 copy number variation" "42" "22" "1.047" "0.984" "0.984" "0.998" "1.038" "0.974" "1.031" "0.995" "1.033" "13734.0" "14376.6" "13509.9" "13513.7" "13699.9" "14255.1" "13375.6" "14165.3" "13663.2" "14182.8" "" "" "" "" "" "" "" "" "" "" "11031.0" "10373.8" "10731.3" "9054.2" "9474.9" "10695.4" "9364.9" "10345.0" "13663.2" "11533.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4804495115062908755" "False" "High" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "0.000" "False" "303.633" "36" "41" "85" "41" "1262" "144.4" "6.15" "293.74" "41" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305; ENSG00000291356" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Amino acid metabolism" "3" "0" "1.000" "1.011" "1.007" "0.957" "0.986" "0.940" "0.942" "0.961" "0.964" "9464.6" "9465.3" "9565.6" "9534.6" "9060.0" "9331.2" "8900.3" "8919.3" "9091.3" "9122.1" "" "" "" "" "" "" "" "" "" "" "7601.8" "6829.9" "7598.3" "6388.1" "6266.0" "7001.1" "6231.5" "6513.8" "9091.3" "7418.4" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459324364456559330" "False" "High" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "0.000" "False" "302.088" "31" "50" "124" "44" "1599" "175.4" "5.33" "371.11" "50" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); ISG15 antiviral mechanism; AUF1 (hnRNP D0) binds and destabilizes mRNA; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "20" "5" "0.973" "0.979" "0.980" "1.024" "0.988" "1.008" "1.015" "1.029" "0.986" "10156.9" "9879.6" "9941.9" "9949.6" "10404.0" "10033.4" "10238.7" "10312.2" "10448.6" "10016.1" "" "" "" "" "" "" "" "" "" "" "8157.9" "7128.8" "7897.2" "6666.2" "7195.5" "7527.9" "7168.6" "7531.1" "10448.6" "8145.5" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973589334991488607" "False" "High" "IsMasterProtein" "Cont_P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "0.000" "True" "297.942" "48" "38" "96" "31" "644" "66.0" "8.12" "319.05" "38" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Formation of the cornified envelope; Neutrophil degranulation" "Corticotropin-releasing hormone signaling pathway" "4" "5" "0.750" "0.304" "0.538" "0.684" "0.967" "2.186" "0.847" "0.644" "0.834" "12427.2" "9317.4" "3775.4" "6687.8" "8495.4" "12019.3" "27161.4" "10528.5" "8002.3" "10366.8" "" "" "" "" "" "" "" "" "" "" "9981.4" "6723.2" "2998.9" "4480.8" "5875.5" "9017.8" "19017.0" "7689.0" "8002.3" "8430.7" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851021478040607723" "False" "High" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "0.000" "False" "295.701" "65" "30" "92" "30" "592" "64.6" "6.71" "324.38" "30" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "One-carbon metabolism" "3" "0" "0.959" "0.986" "0.916" "0.943" "1.016" "0.931" "0.934" "0.962" "0.958" "8083.4" "7753.7" "7967.7" "7405.8" "7624.0" "8209.7" "7528.6" "7551.9" "7774.7" "7743.5" "" "" "" "" "" "" "" "" "" "" "6492.5" "5594.9" "6329.0" "4961.9" "5272.8" "6159.6" "5271.1" "5515.2" "7774.7" "6297.3" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293079878251606526" "False" "High" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "0.000" "False" "295.168" "44" "34" "150" "33" "803" "92.4" "4.84" "536.57" "34" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "0.974" "1.001" "0.967" "0.996" "0.983" "1.010" "1.073" "1.043" "0.981" "12169.0" "11854.5" "12186.1" "11768.9" "12118.5" "11967.0" "12295.3" "13053.1" "12687.2" "11943.7" "" "" "" "" "" "" "" "" "" "" "9774.0" "8553.9" "9679.8" "7885.2" "8381.3" "8978.6" "8608.5" "9532.7" "12687.2" "9713.0" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8291794919948140528" "False" "High" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "0.000" "False" "292.004" "43" "41" "74" "41" "1278" "141.6" "5.81" "267.25" "41" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; XBP1(S) activates chaperone genes" "Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "8" "0" "1.062" "1.023" "1.017" "0.980" "0.946" "0.975" "0.991" "1.021" "1.002" "5149.4" "5470.7" "5267.5" "5236.3" "5044.4" "4870.0" "5022.5" "5102.6" "5257.8" "5161.9" "" "" "" "" "" "" "" "" "" "" "4136.0" "3947.5" "4184.2" "3508.3" "3488.7" "3653.9" "3516.5" "3726.5" "5257.8" "4197.8" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5530158233237029042" "False" "High" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "0.000" "False" "290.936" "36" "48" "67" "48" "1411" "162.4" "5.68" "264.75" "48" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "Toll Like Receptor 9 (TLR9) Cascade" "VEGFA-VEGFR2 signaling" "2" "0" "1.006" "1.005" "1.024" "0.984" "1.008" "0.978" "0.866" "0.995" "0.979" "6196.6" "6231.0" "6224.5" "6346.6" "6099.3" "6245.9" "6060.5" "5365.1" "6165.2" "6065.4" "" "" "" "" "" "" "" "" "" "" "4977.0" "4496.1" "4944.3" "4252.2" "4218.3" "4686.2" "4243.2" "3918.2" "6165.2" "4932.6" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6576828257658518084" "False" "High" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "0.000" "False" "290.344" "65" "24" "234" "3" "449" "49.9" "5.10" "787.45" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; COPI-dependent Golgi-to-ER retrograde traffic; Sealing of the nuclear envelope (NE) by ESCRT-III; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease; HDAC6 interactions in the central nervous system" "37" "1" "1.023" "0.936" "1.062" "1.023" "0.954" "0.985" "0.893" "1.068" "0.920" "596.5" "610.2" "558.5" "633.6" "609.9" "568.9" "587.3" "532.8" "637.3" "548.5" "" "" "" "" "" "" "" "" "" "" "479.1" "440.3" "443.6" "424.5" "421.8" "426.8" "411.2" "389.1" "637.3" "446.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6634363274650926044" "False" "High" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "0.000" "False" "285.284" "30" "52" "82" "42" "1912" "217.9" "5.86" "261.81" "52" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "Q14839; Q8IXZ5" "RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; NGF-stimulated transcription" "Rett syndrome; Effect of progerin on genes involved in progeria" "9" "9" "1.001" "1.050" "0.966" "0.891" "0.959" "0.957" "1.137" "1.038" "0.988" "8008.9" "8015.7" "8412.9" "7738.5" "7135.0" "7681.1" "7665.8" "9107.2" "8315.9" "7910.6" "" "" "" "" "" "" "" "" "" "" "6432.7" "5783.9" "6682.6" "5184.8" "4934.6" "5763.0" "5367.2" "6651.0" "8315.9" "6433.2" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8957423501143175457" "False" "High" "IsMasterProtein" "Cont_P81948" "Tubulin alpha-4A chain OS=Bos taurus OX=9913 GN=TUBA4A PE=1 SV=2" "0.000" "True" "285.251" "61" "23" "186" "5" "448" "49.9" "5.06" "622.81" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100151951; 100302357; 100354352; 100400294; 100449357; 100734500; 100767686; 100995882; 101006121; 101095277; 101148853; 101379814; 101569770; 101606396; 101677236; 101838478; 101926805; 101969889; 102012828; 102177846; 102532857; 102746509; 102841369; 102928867; 102962068; 103007004; 103072784; 103110543; 103217904; 103261248; 103662744; 103727749; 104660054; 105064041; 105481257; 105504700; 105528059; 105587029; 105808789; 105857673; 105996598; 107138719; 107516732; 109265033; 109571050; 22145; 316531; 470654; 478918; 702583; 7277; 777775" "ENSANAG00000028048; ENSBIXG00005021445; ENSBMSG00010001061; ENSBTAG00000030974; ENSCAFG00000015209; ENSCAFG00020027000; ENSCAFG00030011006; ENSCAFG00845029842; ENSCANG00000024607; ENSCATG00000033332; ENSCGRG00001024425; ENSCHIG00000002435; ENSCJAG00000070762; ENSCLAG00000011603; ENSCPOG00000037151; ENSCSAG00000008100; ENSFCAG00000038881; ENSG00000127824; ENSGGOG00000023578; ENSJJAG00000011005; ENSLCNG00005009789; ENSMFAG00000007541; ENSMICG00000035827; ENSMLEG00000029671; ENSMMMG00000020450; ENSMMSG00000019327; ENSMMUG00000019628; ENSMNEG00000039170; ENSMSIG00000018170; ENSMUSG00000026202; ENSNGAG00000020443; ENSNLEG00000027445; ENSOARG00000020020; ENSOCUG00000026994; ENSPANG00000041659; ENSPCOG00000023925; ENSPEMG00000029240; ENSPLOG00000016209; ENSPPAG00000011142; ENSPPYG00000013203; ENSPSMG00000025346; ENSPSNG00000018656; ENSPTEG00000039375; ENSPTIG00000021758; ENSPTRG00000012949; ENSRNOG00000003597; ENSRNOG00055010434; ENSRNOG00060007884; ENSRNOG00065008885; ENSRROG00000044949; ENSSSCG00000016216; ENSSSCG00025016272; ENSSSCG00035020742; ENSSSCG00040017674; ENSSSCG00050039745; ENSSSCG00070016481; ENSSTOG00000019497; ENSSVLG00005016017; ENSTGEG00000012532; ENSTSYG00000011750; ENSUMAG00000018763; ENSUPAG00010012836; ENSVVUG00000025771" "LOC101334183; LOC102532857; LOC102746509; LOC103662744; LOC106970047; LOC109265033; LOC111143142; LOC111171848; LOC112411846; LOC112838391; LOC112872268; LOC112922524; LOC113920876; LOC114495658; LOC118898366; Tuba4a; TUBA4A" "A0A0D9R6X5; A0A1S2ZI83; A0A1S3GBQ2; A0A1U7Q653; A0A1U7TVH0; A0A286ZNY1; A0A2I2UZ20; A0A2I2YM80; A0A2J8NG28; A0A2J8TUH3; A0A2K5DHU1; A0A2K5HTH7; A0A2K5M1H8; A0A2K5Y6I3; A0A2K6D749; A0A2K6GBF8; A0A2K6RS93; A0A2R8ZC21; A0A2U3W3Z0; A0A2U3YH71; A0A2Y9IV09; A0A2Y9N2F1; A0A340WE79; A0A341CW34; A0A384AKZ1; A0A384C1E6; A0A3Q7QMN7; A0A3Q7SCG6; A0A452DNE3; A0A484GTP9; A0A485MVS4; A0A4W2GGR2; A0A4X1UG19; A0A5N3WUA1; A0A663D8Z2; A0A667GI79; A0A6D2XJT6; A0A6I9I9T5; A0A6I9L693; A0A6J1YN80; A0A6J2LL95; A0A6J3RLQ7; A0A6P3CX09; A0A6P3FIC2; A0A6P5D399; A0A6P6ISG9; A0A6P9F8Q5; A0A7J8JNJ1; A0A811ZBS6; A0A8B7EMV4; A0A8B7KBC2; A0A8B8XXA4; A0A8C0LT90; A0A8C0MZ87; A0A8C2N284; A0A8C2VS48; A0A8C5KB95; A0A8C6E681; A0A8C6EXI3; A0A8C6HJF8; A0A8C6RPC4; A0A8C8XN00; A0A8C9ASB4; A0A8C9CIF4; A0A8C9IX37; A0A8C9KT44; A0A8D2D621; A0A8D2K0Z6; A0A8D2KIE8; A0A8I3Q1H9; A0A8I5NZD6; A0A8U0N0J8; A0A9B0TPY2; A0A9V1FEX0; A0A9W3GNM5; A6JVZ9; A8MUB1; aju:106970047; B3KNQ6; biu:109571050; bta:777775; C5ISA2; caty:105587029; cfr:102522237; chx:102177846; cjc:100400294; cpoc:100734500; csyr:103261248; dle:111171848; dord:105996598; elk:111143142; F6QRE8; F7HZP3; fca:101095277; G1RDQ0; G1TR82; H0V3I8; H2P8P0; H2QJG6; hsa:7277; I3NHW3; K9IKB3; lww:102746509; maua:101838478; mcf:101926805; mmu:22145; mmur:105857673; mpuf:101677236; nasi:112411846; ngi:103727749; oas:100302357; ocu:100354352; oro:101379814; P05215; P68366; P68367; P68368; P81948; panu:101006121; pcoo:112872268; pdic:114495658; pon:100449357; pps:100995882; ptg:102962068; Q17QT1; Q3TY31; Q5E986; Q5XIF6; ray:107516732; rno:316531; rro:104660054; ssc:100151951; umr:103662744; vpc:102532857; vvp:112922524" "Platelet degranulation ; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Intraflagellar transport; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Platelet degranulation ; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state; Platelet degranulation ; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Platelet degranulation ; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; RHO GTPases Activate Formins; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Kinesins; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Kinesins; PKR-mediated signaling; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Hedgehog 'off' state; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sealing of the nuclear envelope (NE) by ESCRT-III; Aggrephagy; Recycling pathway of L1; RHO GTPases activate IQGAPs; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; HDAC6 interactions in the central nervous system" "160" "0" "1.039" "0.985" "1.000" "0.937" "0.958" "0.953" "1.026" "0.907" "0.956" "1777.7" "1846.5" "1751.7" "1777.4" "1665.0" "1703.1" "1694.9" "1823.2" "1612.4" "1699.4" "" "" "" "" "" "" "" "" "" "" "1427.8" "1332.3" "1391.4" "1190.9" "1151.6" "1277.8" "1186.7" "1331.5" "1612.4" "1382.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4347150339173577721" "False" "High" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "0.000" "False" "282.075" "39" "54" "93" "54" "1312" "153.8" "6.89" "305.55" "54" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "29" "0" "0.991" "1.010" "1.012" "0.978" "0.987" "0.953" "0.954" "0.975" "0.984" "10000.0" "9914.8" "10102.3" "10116.8" "9775.2" "9874.3" "9527.0" "9542.6" "9746.9" "9842.6" "" "" "" "" "" "" "" "" "" "" "8031.9" "7154.2" "8024.6" "6778.3" "6760.6" "7408.5" "6670.3" "6969.0" "9746.9" "8004.4" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379954125319751521" "False" "High" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "0.000" "False" "281.566" "65" "31" "140" "30" "541" "59.6" "5.66" "470.43" "31" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "0.968" "1.026" "0.969" "0.962" "0.953" "0.947" "0.927" "0.982" "0.963" "12520.8" "12117.4" "12847.5" "12128.9" "12043.0" "11933.3" "11854.4" "11608.5" "12291.3" "12053.9" "" "" "" "" "" "" "" "" "" "" "10056.5" "8743.6" "10205.1" "8126.3" "8329.0" "8953.4" "8299.8" "8477.7" "12291.3" "9802.6" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "626595147841982495" "False" "High" "IsMasterProtein" "Q92835" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2" "0.000" "False" "278.353" "39" "40" "65" "38" "1189" "133.2" "7.59" "254.12" "40" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00017" "3635" "ENSG00000168918; ENSG00000281614" "INPP5D" "hsa:3635; O00145; Q13544; Q13545; Q6P5A4; Q92656; Q92835; Q9UE80" "Downstream TCR signaling; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Synthesis of IP3 and IP4 in the cytosol; PECAM1 interactions" "B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway; Netrin-UNC5B signaling pathway; 5q35 copy number variation" "13" "2" "0.992" "0.994" "0.973" "1.000" "1.006" "0.981" "0.976" "0.973" "1.007" "5655.9" "5610.5" "5622.2" "5500.6" "5656.7" "5691.5" "5547.5" "5518.1" "5504.6" "5694.6" "" "" "" "" "" "" "" "" "" "" "4542.7" "4048.4" "4465.9" "3685.4" "3912.2" "4270.2" "3884.1" "4029.9" "5504.6" "4631.1" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2651873567954206530" "False" "High" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "0.000" "False" "276.666" "36" "35" "87" "35" "1176" "134.4" "7.30" "323.84" "35" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "0.976" "0.992" "0.973" "0.985" "0.974" "0.975" "0.976" "0.947" "0.991" "9169.1" "8950.0" "9095.8" "8925.9" "9030.3" "8932.5" "8942.0" "8946.1" "8686.6" "9087.3" "" "" "" "" "" "" "" "" "" "" "7364.5" "6458.0" "7225.1" "5980.3" "6245.4" "6701.9" "6260.7" "6533.4" "8686.6" "7390.1" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6560846777174153588" "False" "High" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "0.000" "False" "276.290" "38" "42" "77" "42" "1224" "138.3" "7.66" "261.04" "42" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "" "2" "0" "1.002" "1.013" "1.007" "0.961" "0.975" "0.932" "0.961" "0.955" "0.966" "6366.4" "6379.5" "6451.0" "6410.8" "6115.1" "6207.8" "5936.0" "6117.0" "6078.9" "6146.9" "" "" "" "" "" "" "" "" "" "" "5113.4" "4603.3" "5124.3" "4295.2" "4229.2" "4657.6" "4156.1" "4467.2" "6078.9" "4998.8" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5341813448089902722" "False" "High" "IsMasterProtein" "P16885" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4" "0.000" "False" "276.239" "41" "44" "103" "42" "1265" "147.8" "6.64" "306.00" "44" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf16457" "5336" "ENSG00000197943" "PLCG2" "D3DUL3; hsa:5336; P16885; Q3ZTS2; Q59H45; Q969T5" "Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; DAP12 signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family" "Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; GDNF signaling; 2q13 copy number variation syndrome; ErbB signaling pathway" "30" "0" "1.002" "0.993" "1.014" "1.000" "0.981" "0.960" "0.945" "0.959" "0.982" "9449.4" "9466.6" "9386.6" "9577.4" "9451.0" "9267.0" "9071.5" "8930.0" "9059.5" "9279.6" "" "" "" "" "" "" "" "" "" "" "7589.7" "6830.9" "7456.1" "6416.9" "6536.4" "6952.9" "6351.4" "6521.6" "9059.5" "7546.5" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649453304125061400" "False" "High" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "0.000" "False" "275.097" "39" "29" "97" "23" "894" "95.3" "8.76" "334.99" "29" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528, Pf20965" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "PKR-mediated signaling; Regulation of CDH11 gene transcription" "" "2" "5" "1.015" "1.046" "1.018" "1.009" "1.025" "1.016" "0.999" "1.006" "1.014" "7615.0" "7728.9" "7964.2" "7753.8" "7684.2" "7801.8" "7736.6" "7607.5" "7663.3" "7724.8" "" "" "" "" "" "" "" "" "" "" "6116.3" "5577.0" "6326.2" "5195.0" "5314.4" "5853.5" "5416.8" "5555.8" "7663.3" "6282.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629072451512354259" "False" "High" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0.000" "False" "273.870" "32" "38" "75" "37" "1360" "152.7" "6.90" "243.71" "38" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "8" "0" "0.990" "0.966" "0.980" "0.956" "0.945" "1.023" "1.109" "1.049" "0.994" "6373.0" "6308.0" "6154.0" "6245.2" "6094.2" "6022.9" "6519.2" "7066.8" "6685.9" "6337.6" "" "" "" "" "" "" "" "" "" "" "5118.7" "4551.7" "4888.3" "4184.3" "4214.8" "4518.9" "4564.4" "5160.9" "6685.9" "5154.0" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6480137070562712140" "False" "High" "IsMasterProtein" "Cont_Q2KJD0" "Tubulin beta-5 chain OS=Bos taurus OX=9913 GN=TUBB5 PE=2 SV=1" "0.000" "True" "273.738" "66" "22" "252" "5" "444" "49.6" "4.89" "726.29" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100022562; 100172938; 100303606; 100598146; 100689091; 100718713; 100918219; 100998701; 101034943; 101095657; 101129890; 101318992; 101341456; 101365832; 101593768; 101827904; 101925816; 101965993; 102168953; 102382532; 102506772; 102536943; 102568349; 102831964; 102882060; 102926495; 102963307; 103014346; 103053177; 103080542; 103205965; 103221819; 103261319; 103665004; 104666199; 105074100; 105087494; 105308138; 105498618; 105513957; 105553127; 105600022; 105704569; 105817283; 105855398; 105996956; 106553108; 106825507; 106966617; 107160457; 107498082; 108520633; 108522550; 109249509; 109693530; 203068; 22154; 29214; 396254; 471960; 474830; 574113; 615087; 733686" "ENSACCG00020016918; ENSAMEG00000014418; ENSANAG00000034194; ENSANIG00000003763; ENSAOWG00000004252; ENSBGRG00000008599; ENSBIXG00000008022; ENSBIXG00005015569; ENSBMSG00010013877; ENSBTAG00000006969; ENSCABG00000008181; ENSCAFG00000000443; ENSCAFG00040015599; ENSCAFG00845007927; ENSCANG00000012112; ENSCATG00000014335; ENSCCNG00000028823; ENSCGRG00000007995; ENSCGRG00001023930; ENSCGRG00015028239; ENSCHIG00000025610; ENSCJAG00000048479; ENSCMUG00000016892; ENSCPOG00000035463; ENSCRFG00000007002; ENSCSAG00000008279; ENSCWAG00000006690; ENSEASG00005019680; ENSFCAG00000027444; ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067; ENSGAGG00000007027; ENSGGOG00000022655; ENSJJAG00000024145; ENSLCNG00005007041; ENSMFAG00000044340; ENSMICG00000010647; ENSMLEG00000037482; ENSMMMG00000020216; ENSMMNG00015000200; ENSMMNG00015000533; ENSMMNG00015004763; ENSMMSG00000005300; ENSMMUG00000030028; ENSMNEG00000044824; ENSMODG00000023805; ENSMSIG00000015128; ENSMUSG00000001525; ENSNLEG00000005348; ENSOANG00000004061; ENSOARG00000011626; ENSPANG00000015954; ENSPCLG00000013695; ENSPCOG00000022809; ENSPCTG00005009625; ENSPEMG00000025556; ENSPLOG00000016488; ENSPPYG00000016419; ENSPSNG00000012487; ENSPTEG00000030284; ENSPTIG00000006316; ENSPTRG00000017675; ENSRBIG00000034281; ENSRFEG00010000368; ENSRNOG00000061216; ENSRNOG00055006845; ENSRNOG00060003580; ENSRNOG00065029671; ENSRROG00000035442; ENSSBOG00000020987; ENSSDAG00000016166; ENSSHAG00000028751; ENSSHBG00005000940; ENSSOCG00000016453; ENSSSCG00000001379; ENSSSCG00015022877; ENSSSCG00025077784; ENSSSCG00030060370; ENSSSCG00035060189; ENSSSCG00040067819; ENSSSCG00050020383; ENSSSCG00055030461; ENSSSCG00060047808; ENSSSCG00065051381; ENSSSCG00070024618; ENSSSUG00005002289; ENSSTOG00000023492; ENSSVLG00005006345; ENSTGEG00000009306; ENSTGEG00000012139; ENSTGUG00000029087; ENSTSYG00000035292; ENSUAMG00000026276; ENSUMAG00000019678; ENSUPAG00010003937; ENSVURG00010001582; ENSVVUG00000009892; ENSZLMG00000006871" "LOC101341456; LOC106553108; LOC111152509; LOC112622444; LOC114901775; LOC115493080; LOC116436919; TBB7; Tubb; TUBB; Tubb5; TUBB5" "A0A0B8RPP1; A0A0D9R7E7; A0A151MZH9; A0A1S3GEI3; A0A1U7R7I2; A0A1U7SI21; A0A1U7TVN8; A0A1V4L0F2; A0A1W7RC49; A0A218U794; A0A286XDY8; A0A2D4LT52; A0A2D4PSK3; A0A2I3MS98; A0A2J8NXA1; A0A2J8SJF9; A0A2K5EIS8; A0A2K5HGL3; A0A2K5KT86; A0A2K5WBU4; A0A2K5ZFW6; A0A2K6E8N3; A0A2K6G5S3; A0A2K6LAT7; A0A2K6Q336; A0A2K6SLG3; A0A2U3V2D1; A0A2U3WJT7; A0A2Y9EAZ4; A0A2Y9EP82; A0A2Y9HLQ0; A0A2Y9K0M9; A0A2Y9MS78; A0A340WI11; A0A341AY80; A0A384BFD0; A0A384C9R0; A0A387L8L1; A0A3Q7RLV2; A0A3Q7S184; A0A452G3S8; A0A452H2Z1; A0A452SPC5; A0A480TK33; A0A485NK51; A0A4D9DG40; A0A4W2C297; A0A4X2JR93; A0A5E4AVV9; A0A5N3VZ42; A0A5N3WG73; A0A5N4CSN6; A0A663FK44; A0A667GBL5; A0A669QEL9; A0A671DQJ6; A0A672TGM1; A0A673T1T3; A0A674HV74; A0A6B2F8Z8; A0A6B2F9Q6; A0A6I9ILN3; A0A6I9MI92; A0A6I9YS87; A0A6I9ZH14; A0A6J0V952; A0A6J0X5U3; A0A6J1VI28; A0A6J2LA47; A0A6J3H9X1; A0A6P3EF00; A0A6P3RZ49; A0A6P5RBI7; A0A6P6HAZ1; A0A6P7XJA2; A0A6P8P8N4; A0A6P9CC67; A0A6P9FE20; A0A7J7R527; A0A7J7RLA9; A0A7J8GU45; A0A7J8KJ46; A0A7N4PPV2; A0A811YN81; A0A8B7ATI1; A0A8B7EBT6; A0A8B7VFP4; A0A8B9M868; A0A8B9P6J0; A0A8B9X0N8; A0A8C0I1Y2; A0A8C0IPC0; A0A8C0SSP9; A0A8C3VZK5; A0A8C3XAR0; A0A8C4PT60; A0A8C5LKQ9; A0A8C6AUQ3; A0A8C6EXU6; A0A8C6FHM7; A0A8C6MWA3; A0A8C8XQA1; A0A8C9BZ32; A0A8C9I594; A0A8C9J767; A0A8C9USK8; A0A8D0FX24; A0A8D2B3E9; A0A8D2EVN1; A0A8D2GXX0; A0A8D2P6S2; A0A8I3N9K0; A0A8K1G105; A0A8U0NH48; A0A8U7NRV1; A0A9B0X0S4; A0A9F2WGG8; A0A9V1E7C8; A0A9W3GX28; A0A9X9LVU0; A0AA35K0A2; A5D9A3; A6KT85; aju:106966617; amj:102568349; asn:102382532; B1B178; bacu:103014346; bta:615087; caty:105600022; ccan:109693530; cdk:105087494; cfa:474830; cfr:102506772; cge:100689091; chx:102168953; cpoc:100718713; csab:103221819; csyr:103261319; dle:111170669; dord:105996956; F6TYN8; F7F082; fca:101095657; G1LKN6; G1R063; G3HQP8; G3SB76; gga:396254; ggo:101129890; gsh:117346094; hsa:203068; I3ND93; J3S5D8; L5KK71; M3X7Z9; maua:101827904; mcal:110312171; mcc:574113; mdo:100022562; mmu:22154; mmur:105855398; mni:105498618; mpuf:101674529; muo:115466267; nasi:112395403; nle:100598146; nss:113423183; nsu:110586671; oas:100303606; oro:101365832; P05218; P07437; P09244; P69893; P69895; P69897; P99024; pale:102882060; panu:100998701; pbi:103053177; pcad:102979859; pcoq:105817283; pdic:114493854; pgut:117667950; pon:100172938; ptg:102963307; ptr:471960; pvp:105308138; pvt:110090161; Q1XHT6; Q2KJD0; Q3TFB6; Q3THH9; Q3TIL1; Q3UAV4; Q3UF52; Q5R943; Q5SU16; Q5TM69; Q6P9X8; Q767L7; Q7JJU6; Q8WUC1; Q9CY33; ray:107498082; rbb:108520633; rbb:108522550; rno:29214; rro:104666199; S9WJD1; sbq:101034943; shr:100918219; ssc:733686; T1DHR5; tmu:101341456; tsr:106553108; U3FAQ9; U3FM57; umr:103665004; vpc:102536943; vvp:112913571; W5PPT6; zca:113927996" "Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Potential therapeutics for SARS; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease; HDAC6 interactions in the central nervous system" "57" "20" "1.078" "0.991" "1.014" "0.991" "1.013" "0.989" "1.017" "0.999" "1.013" "11922.5" "12850.4" "11819.2" "12093.6" "11815.8" "12076.1" "11796.6" "12120.1" "11911.8" "12082.6" "" "" "" "" "" "" "" "" "" "" "9576.0" "9272.5" "9388.4" "8102.7" "8171.9" "9060.5" "8259.4" "8851.3" "11911.8" "9826.0" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5753903603639706733" "False" "High" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0.000" "False" "273.609" "38" "41" "73" "40" "1401" "157.1" "6.61" "253.19" "41" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "Condensation of Prometaphase Chromosomes" "" "1" "0" "1.000" "0.981" "1.022" "0.985" "0.974" "0.906" "0.926" "0.922" "0.989" "3800.8" "3801.6" "3727.4" "3883.8" "3742.5" "3700.9" "3442.9" "3520.7" "3505.4" "3759.1" "" "" "" "" "" "" "" "" "" "" "3052.7" "2743.1" "2960.8" "2602.2" "2588.4" "2776.7" "2410.5" "2571.1" "3505.4" "3057.0" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299836175419688438" "False" "High" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "0.000" "False" "273.487" "50" "28" "66" "28" "694" "75.4" "7.66" "255.89" "28" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "2" "0" "1.017" "1.024" "0.978" "0.977" "1.004" "0.949" "1.050" "1.047" "1.004" "4266.6" "4338.6" "4370.1" "4174.5" "4169.3" "4282.0" "4050.5" "4479.7" "4466.3" "4282.2" "" "" "" "" "" "" "" "" "" "" "3426.9" "3130.6" "3471.3" "2796.9" "2883.5" "3212.7" "2835.9" "3271.5" "4466.3" "3482.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-516006275001987462" "False" "High" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "0.000" "False" "272.691" "44" "36" "85" "36" "821" "92.8" "5.41" "293.34" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "11" "0" "1.002" "1.029" "0.960" "0.981" "0.947" "0.966" "1.008" "1.013" "0.978" "7268.0" "7285.5" "7481.4" "6977.7" "7130.4" "6882.4" "7021.3" "7326.9" "7366.0" "7107.6" "" "" "" "" "" "" "" "" "" "" "5837.6" "5257.0" "5942.7" "4675.0" "4931.4" "5163.7" "4915.9" "5350.8" "7366.0" "5780.2" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6973941838255417452" "False" "High" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "0.000" "False" "269.874" "38" "29" "93" "29" "900" "101.1" "6.16" "331.61" "29" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "0.975" "0.990" "1.000" "0.969" "0.955" "0.970" "0.976" "0.929" "0.967" "8569.5" "8358.0" "8483.0" "8568.2" "8303.7" "8180.6" "8310.3" "8364.3" "7961.1" "8288.1" "" "" "" "" "" "" "" "" "" "" "6882.9" "6030.9" "6738.3" "5740.7" "5742.9" "6137.7" "5818.5" "6108.5" "7961.1" "6740.2" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7479442399663165637" "False" "High" "IsMasterProtein" "Cont_P02769" "Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4" "0.000" "True" "263.817" "63" "37" "97" "36" "607" "69.2" "6.18" "331.53" "37" "stress response;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "280717" "" "ALB" "A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2" "" "" "0" "1" "0.985" "0.733" "1.053" "0.818" "1.041" "1.428" "0.948" "0.875" "0.956" "10247.5" "10094.8" "7514.8" "10789.3" "8383.7" "10667.7" "14637.9" "9710.7" "8971.0" "9793.5" "" "" "" "" "" "" "" "" "" "" "8230.7" "7284.1" "5969.3" "7228.8" "5798.3" "8003.8" "10248.7" "7091.8" "8971.0" "7964.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1414691960117410819" "False" "High" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "0.000" "False" "262.989" "52" "37" "80" "36" "863" "96.5" "6.74" "276.99" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf21128" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "12" "1" "0.981" "1.004" "0.975" "0.947" "0.936" "0.986" "1.017" "1.001" "0.959" "6297.3" "6179.0" "6320.8" "6140.7" "5964.8" "5893.9" "6208.9" "6407.4" "6305.2" "6036.6" "" "" "" "" "" "" "" "" "" "" "5057.9" "4458.6" "5020.8" "4114.3" "4125.3" "4422.1" "4347.1" "4679.4" "6305.2" "4909.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546682892855641805" "False" "High" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "0.000" "False" "262.028" "50" "22" "75" "21" "514" "55.8" "6.90" "303.12" "22" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "Rett syndrome" "5" "1" "0.963" "0.980" "0.949" "0.961" "0.953" "0.934" "0.959" "0.912" "0.965" "7222.9" "6955.6" "7075.9" "6857.0" "6941.9" "6880.9" "6748.5" "6923.4" "6590.2" "6971.8" "" "" "" "" "" "" "" "" "" "" "5801.4" "5019.0" "5620.6" "4594.2" "4801.1" "5162.6" "4724.9" "5056.2" "6590.2" "5669.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7224600777690592247" "False" "High" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "0.000" "False" "261.971" "61" "31" "118" "30" "539" "57.9" "7.83" "380.56" "31" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "1" "0.997" "1.006" "0.996" "1.001" "0.976" "0.992" "0.968" "0.958" "0.977" "7628.0" "7602.5" "7677.5" "7595.8" "7636.7" "7442.2" "7569.5" "7385.9" "7305.8" "7455.1" "" "" "" "" "" "" "" "" "" "" "6126.8" "5485.7" "6098.5" "5089.2" "5281.6" "5583.7" "5299.8" "5394.0" "7305.8" "6062.8" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4595887854081889880" "False" "High" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "0.000" "False" "260.529" "39" "30" "71" "30" "953" "105.8" "5.39" "261.42" "30" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004, Pf21505" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Somitogenesis; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC)" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "0.990" "0.999" "0.988" "0.995" "0.980" "0.978" "1.003" "1.006" "0.970" "5968.6" "5910.6" "5963.2" "5895.7" "5938.8" "5850.8" "5834.7" "5986.0" "6002.5" "5787.2" "" "" "" "" "" "" "" "" "" "" "4794.0" "4264.9" "4736.7" "3950.1" "4107.3" "4389.8" "4085.1" "4371.6" "6002.5" "4706.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3490068427957957642" "False" "High" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "0.000" "False" "260.502" "48" "36" "79" "36" "968" "106.7" "5.53" "261.35" "36" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "Cytosolic tRNA aminoacylation" "IL-18 signaling pathway" "2" "0" "0.997" "1.028" "1.005" "0.982" "0.990" "0.999" "0.969" "1.003" "0.981" "7773.1" "7748.8" "7987.7" "7811.4" "7636.8" "7693.1" "7766.0" "7532.4" "7794.2" "7622.8" "" "" "" "" "" "" "" "" "" "" "6243.3" "5591.3" "6344.9" "5233.6" "5281.7" "5772.0" "5437.3" "5500.9" "7794.2" "6199.1" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952006714438079555" "False" "High" "IsMasterProtein" "Q9Y4L1" "Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1" "0.000" "False" "260.369" "46" "37" "61" "37" "999" "111.3" "5.22" "231.66" "37" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00012" "10525" "ENSG00000149428; ENSG00000280682" "HYOU1" "A8C1Z0; B7Z909; hsa:10525; Q2I204; Q53H25; Q9Y4L1" "XBP1(S) activates chaperone genes; Scavenging by Class F Receptors" "VEGFA-VEGFR2 signaling" "3" "0" "1.005" "0.973" "1.011" "1.011" "0.981" "1.019" "1.051" "1.047" "1.010" "5514.8" "5541.4" "5365.9" "5573.1" "5576.3" "5410.5" "5618.5" "5795.3" "5772.4" "5570.0" "" "" "" "" "" "" "" "" "" "" "4429.5" "3998.5" "4262.3" "3734.0" "3856.6" "4059.4" "3933.8" "4232.3" "5772.4" "4529.7" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5449770128653317074" "False" "High" "IsMasterProtein" "Cont_P15636" "Protease 1 OS=Achromobacter lyticus OX=224 PE=1 SV=1" "0.000" "True" "258.472" "19" "13" "496" "13" "653" "68.1" "7.24" "1879.36" "13" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf01483, Pf18911" "" "" "" "" "" "" "0" "0" "0.975" "0.935" "1.021" "1.021" "1.034" "1.003" "0.964" "1.047" "1.018" "25864.0" "25221.4" "24187.0" "26404.7" "26398.1" "26737.9" "25932.6" "24922.5" "27091.3" "26336.5" "" "" "" "" "" "" "" "" "" "" "20773.7" "18199.0" "19212.5" "17691.2" "18257.1" "20061.0" "18156.6" "18200.9" "27091.3" "21417.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2859585786570282431" "False" "High" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "0.000" "False" "258.158" "46" "26" "75" "23" "780" "85.1" "7.99" "281.98" "26" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Glycolysis" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "1" "1.000" "1.026" "0.986" "1.017" "1.019" "0.982" "0.952" "0.943" "0.975" "3546.1" "3545.8" "3638.6" "3495.9" "3606.6" "3613.1" "3482.2" "3375.2" "3345.5" "3457.1" "" "" "" "" "" "" "" "" "" "" "2848.2" "2558.5" "2890.3" "2342.3" "2494.3" "2710.8" "2438.1" "2464.9" "3345.5" "2811.5" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205545228874989707" "False" "High" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "0.000" "False" "255.415" "36" "34" "65" "32" "1129" "124.3" "6.61" "229.99" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Pathophysiological roles of DUX4 in FSHD1" "3" "2" "1.049" "1.018" "1.030" "1.054" "1.049" "0.987" "1.069" "1.027" "1.040" "4326.3" "4536.6" "4405.7" "4456.8" "4561.0" "4538.6" "4268.5" "4626.3" "4442.8" "4499.2" "" "" "" "" "" "" "" "" "" "" "3474.8" "3273.5" "3499.6" "2986.0" "3154.4" "3405.3" "2988.6" "3378.6" "4442.8" "3658.9" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6718063858029524947" "False" "High" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "0.000" "False" "254.880" "63" "28" "116" "21" "445" "50.6" "6.47" "392.20" "28" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation" "" "2" "6" "0.949" "0.994" "0.918" "0.935" "0.948" "0.905" "0.912" "0.906" "0.930" "12535.8" "11892.0" "12460.3" "11509.8" "11716.1" "11879.7" "11339.3" "11435.6" "11353.1" "11661.7" "" "" "" "" "" "" "" "" "" "" "10068.6" "8580.9" "9897.6" "7711.6" "8102.9" "8913.1" "7939.2" "8351.5" "11353.1" "9483.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985965989456980911" "False" "High" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0.000" "False" "254.691" "29" "38" "61" "38" "1508" "168.5" "6.62" "221.52" "38" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894, Pf21720" "25929" "ENSG00000082516" "GEMIN5" "Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "1.020" "1.005" "1.005" "1.027" "0.998" "1.003" "0.991" "0.994" "1.005" "6704.7" "6839.6" "6739.7" "6735.7" "6887.9" "6688.6" "6721.6" "6641.7" "6665.3" "6739.4" "" "" "" "" "" "" "" "" "" "" "5385.2" "4935.2" "5353.6" "4512.9" "4763.7" "5018.4" "4706.1" "4850.5" "6665.3" "5480.7" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2214005141303334461" "False" "High" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "0.000" "False" "254.291" "54" "30" "109" "30" "609" "69.8" "6.64" "372.99" "30" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; HDAC6 interactions in the central nervous system" "9" "0" "0.979" "1.010" "0.954" "0.971" "0.951" "0.932" "0.971" "0.977" "0.968" "9118.8" "8924.6" "9210.0" "8703.9" "8854.6" "8670.6" "8502.6" "8857.5" "8912.7" "8822.9" "" "" "" "" "" "" "" "" "" "" "7324.2" "6439.8" "7315.8" "5831.6" "6123.9" "6505.4" "5953.1" "6468.6" "8912.7" "7175.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771455182534441899" "False" "High" "IsMasterProtein" "P11137" "Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4" "0.000" "False" "253.988" "28" "40" "58" "40" "1827" "199.4" "4.91" "219.72" "40" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418, Pf08377" "4133" "ENSG00000078018" "MAP2" "hsa:4133; P11137; Q17S04; Q8IUX2; Q99975; Q99976" "" "Melatonin metabolism and effects; MAPK cascade; Neurogenesis regulation in the olfactory epithelium; Cell lineage map for neuronal differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "0.999" "0.977" "1.005" "1.009" "0.983" "0.950" "1.016" "0.961" "1.001" "4525.9" "4521.8" "4420.5" "4546.4" "4566.1" "4449.5" "4299.0" "4596.8" "4347.9" "4531.7" "" "" "" "" "" "" "" "" "" "" "3635.1" "3262.8" "3511.3" "3046.1" "3158.0" "3338.4" "3009.9" "3357.0" "4347.9" "3685.3" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646758734319931850" "False" "High" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "0.000" "False" "252.836" "61" "23" "74" "22" "572" "62.3" "6.38" "268.97" "23" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Recycling pathway of L1; CRMPs in Sema3A signaling" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "4" "0" "0.989" "0.999" "1.000" "0.947" "0.951" "0.985" "0.970" "0.960" "0.981" "6356.0" "6285.1" "6346.7" "6358.1" "6016.7" "6045.1" "6258.3" "6162.3" "6101.7" "6232.2" "" "" "" "" "" "" "" "" "" "" "5105.1" "4535.2" "5041.4" "4259.9" "4161.2" "4535.5" "4381.7" "4500.3" "6101.7" "5068.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8676466481375871245" "False" "High" "IsMasterProtein" "P08133" "Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3" "0.000" "False" "252.529" "59" "36" "88" "36" "673" "75.8" "5.60" "294.63" "36" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00191" "309" "ENSG00000197043" "ANXA6" "B7Z8A7; D3DQH4; E9PGK1; hsa:309; P08133; Q6ZT79" "Smooth Muscle Contraction" "Calcium regulation in cardiac cells; Prostaglandin synthesis and regulation" "3" "0" "0.982" "1.070" "0.995" "1.002" "0.999" "0.880" "0.878" "0.910" "0.949" "6508.6" "6389.8" "6966.7" "6477.1" "6521.7" "6502.8" "5725.4" "5715.6" "5921.5" "6179.7" "" "" "" "" "" "" "" "" "" "" "5227.6" "4610.7" "5533.9" "4339.6" "4510.5" "4878.9" "4008.6" "4174.1" "5921.5" "5025.6" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6674387397432112473" "False" "High" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "0.000" "False" "251.965" "67" "22" "227" "2" "445" "49.8" "4.89" "662.07" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "MHC class II antigen presentation; COPI-mediated anterograde transport; PKR-mediated signaling; HCMV Early Events; Neutrophil degranulation; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "42" "4" "1.010" "0.995" "0.927" "0.968" "0.943" "0.892" "0.998" "1.038" "0.969" "3610.7" "3646.7" "3592.9" "3347.1" "3495.8" "3403.7" "3221.7" "3603.8" "3749.0" "3499.6" "" "" "" "" "" "" "" "" "" "" "2900.1" "2631.4" "2853.9" "2242.6" "2417.7" "2553.7" "2255.6" "2631.9" "3749.0" "2846.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619416957405686977" "False" "High" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "0.000" "False" "251.681" "41" "25" "75" "25" "788" "85.2" "4.30" "277.84" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "1.007" "1.000" "0.986" "0.951" "1.001" "1.088" "1.049" "1.010" "0.992" "7090.5" "7140.8" "7089.6" "6989.6" "6745.2" "7096.0" "7711.9" "7441.2" "7160.9" "7030.8" "" "" "" "" "" "" "" "" "" "" "5695.0" "5152.6" "5631.5" "4683.1" "4665.0" "5324.0" "5399.5" "5434.4" "7160.9" "5717.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453678624484122586" "False" "High" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "0.000" "False" "251.261" "43" "35" "76" "35" "868" "96.0" "6.52" "263.53" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "5" "0" "1.006" "1.008" "0.979" "0.976" "0.997" "0.964" "1.010" "0.995" "0.982" "7583.9" "7633.0" "7641.2" "7422.9" "7400.5" "7562.3" "7310.5" "7663.3" "7548.8" "7447.2" "" "" "" "" "" "" "" "" "" "" "6091.3" "5507.8" "6069.7" "4973.3" "5118.2" "5673.9" "5118.5" "5596.6" "7548.8" "6056.3" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256395688163039861" "False" "High" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "0.000" "False" "250.735" "26" "49" "66" "48" "2136" "244.4" "6.06" "220.30" "49" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149, Pf21188" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2q11.2 copy number variation syndrome" "3" "1" "0.980" "1.041" "0.989" "0.958" "1.008" "0.928" "0.986" "0.958" "0.980" "5059.3" "4958.9" "5264.7" "5001.7" "4847.1" "5098.6" "4697.4" "4990.1" "4848.9" "4959.5" "" "" "" "" "" "" "" "" "" "" "4063.6" "3578.2" "4181.9" "3351.1" "3352.3" "3825.4" "3288.8" "3644.3" "4848.9" "4033.3" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172904709922305924" "False" "High" "IsMasterProtein" "Q5UIP0" "Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2" "0.000" "False" "250.304" "20" "43" "58" "43" "2472" "274.3" "5.52" "204.92" "43" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf12231" "55183" "ENSG00000080345" "RIF1" "A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4" "Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome" "3" "0" "1.006" "0.986" "0.970" "0.956" "0.972" "0.960" "1.044" "1.035" "1.004" "4993.1" "5024.5" "4924.2" "4845.8" "4774.6" "4852.1" "4791.1" "5212.7" "5166.6" "5012.4" "" "" "" "" "" "" "" "" "" "" "4010.4" "3625.5" "3911.5" "3246.7" "3302.2" "3640.5" "3354.5" "3806.8" "5166.6" "4076.2" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8215909947984891721" "False" "High" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "0.000" "False" "248.779" "33" "34" "80" "34" "1152" "120.9" "5.43" "269.70" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "2" "0" "0.963" "1.013" "0.964" "1.013" "0.998" "1.011" "0.993" "1.015" "0.989" "8592.8" "8277.8" "8705.7" "8286.6" "8707.0" "8579.0" "8691.0" "8529.6" "8725.0" "8502.1" "" "" "" "" "" "" "" "" "" "" "6901.6" "5973.0" "6915.2" "5552.0" "6021.8" "6436.7" "6085.0" "6229.2" "8725.0" "6914.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7989790464056543145" "False" "High" "IsMasterProtein" "Cont_P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "0.000" "True" "248.692" "53" "25" "64" "23" "623" "62.0" "5.24" "234.41" "25" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "3857; 454664" "ENSG00000171403; ENSPTRG00000009169" "KRT9" "A0A2J8KG96; A0A6D2VYW7; H2QCZ6; hsa:3857; O00109; P35527; ptr:454664; Q0IJ47; Q14665" "Formation of the cornified envelope" "" "2" "1" "0.802" "0.310" "0.528" "0.713" "1.191" "3.569" "0.920" "0.809" "1.059" "5217.6" "4184.9" "1615.3" "2752.8" "3721.4" "6214.5" "18622.9" "4799.5" "4221.5" "5526.3" "" "" "" "" "" "" "" "" "" "" "4190.7" "3019.7" "1283.0" "1844.4" "2573.8" "4662.7" "13038.8" "3505.1" "4221.5" "4494.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8375301801822560127" "False" "High" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "0.000" "False" "248.689" "34" "28" "102" "27" "959" "106.4" "6.39" "333.63" "28" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "Mitochondrial protein degradation" "" "1" "1" "1.008" "1.027" "0.985" "0.999" "0.990" "0.944" "0.959" "0.989" "0.980" "9940.8" "10019.2" "10213.6" "9792.7" "9933.4" "9843.5" "9386.2" "9529.2" "9828.6" "9745.3" "" "" "" "" "" "" "" "" "" "" "7984.4" "7229.6" "8113.0" "6561.1" "6870.1" "7385.4" "6571.7" "6959.2" "9828.6" "7925.2" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4943408873611006946" "False" "High" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "0.000" "False" "247.661" "64" "29" "125" "29" "459" "51.8" "5.43" "388.79" "29" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Estrogen-dependent gene expression; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "Androgen receptor signaling pathway" "6" "0" "0.991" "0.997" "1.010" "0.962" "0.953" "0.967" "0.929" "0.982" "0.978" "10431.1" "10334.9" "10404.4" "10537.5" "10033.4" "9939.1" "10092.0" "9694.8" "10247.9" "10196.8" "" "" "" "" "" "" "" "" "" "" "8378.1" "7457.4" "8264.6" "7060.1" "6939.2" "7457.2" "7065.9" "7080.2" "10247.9" "8292.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243510454319930112" "False" "High" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "0.000" "False" "247.622" "45" "32" "82" "32" "734" "82.2" "8.37" "286.32" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication" "10" "0" "0.996" "1.014" "1.007" "0.978" "0.986" "1.025" "1.040" "1.022" "1.010" "7605.7" "7575.1" "7714.4" "7660.0" "7439.4" "7497.7" "7795.4" "7906.2" "7771.8" "7681.0" "" "" "" "" "" "" "" "" "" "" "6108.8" "5466.0" "6127.8" "5132.2" "5145.1" "5625.4" "5458.0" "5773.9" "7771.8" "6246.4" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6605193621902288169" "False" "High" "IsMasterProtein" "Cont_P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "0.000" "True" "245.815" "60" "30" "52" "24" "639" "65.4" "8.00" "193.82" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "Formation of the cornified envelope" "" "2" "2" "0.624" "0.304" "0.603" "1.216" "1.737" "1.456" "1.346" "0.519" "0.937" "3347.3" "2087.8" "1019.0" "2017.1" "4069.8" "5815.8" "4874.4" "4504.9" "1736.0" "3135.8" "" "" "" "" "" "" "" "" "" "" "2688.5" "1506.5" "809.5" "1351.5" "2814.7" "4363.5" "3412.8" "3289.9" "1736.0" "2550.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6496925005546959600" "False" "High" "IsMasterProtein" "Q13509" "Tubulin beta-3 chain OS=Homo sapiens OX=9606 GN=TUBB3 PE=1 SV=2" "0.000" "False" "245.609" "57" "19" "202" "6" "450" "50.4" "4.93" "581.85" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10381" "ENSG00000258947" "TUBB3" "A8K854; hsa:10381; Q13509; Q9BTZ0; Q9BW10" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Hedgehog 'off' state; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Post-chaperonin tubulin folding pathway; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Prefoldin mediated transfer of substrate to CCT/TriC" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Exercise-induced circadian regulation; Alzheimer's disease; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "38" "2" "0.970" "0.958" "0.965" "0.973" "0.952" "0.983" "0.992" "0.901" "0.953" "2891.8" "2804.7" "2769.5" "2789.6" "2812.9" "2753.7" "2843.2" "2868.7" "2606.0" "2756.8" "" "" "" "" "" "" "" "" "" "" "2322.6" "2023.8" "2199.9" "1869.0" "1945.5" "2066.1" "1990.7" "2095.0" "2606.0" "2241.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949671281598126574" "False" "High" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "0.000" "False" "245.425" "36" "47" "76" "42" "1354" "158.1" "5.90" "262.36" "47" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; RND3 GTPase cycle; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle; Apoptotic cleavage of cellular proteins" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "35" "4" "0.973" "0.972" "0.989" "0.969" "0.940" "1.000" "0.970" "0.971" "0.970" "7747.5" "7535.0" "7533.9" "7659.0" "7509.0" "7281.6" "7751.1" "7512.5" "7520.5" "7512.6" "" "" "" "" "" "" "" "" "" "" "6222.7" "5437.1" "5984.4" "5131.5" "5193.3" "5463.3" "5426.9" "5486.4" "7520.5" "6109.5" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874142018275296018" "False" "High" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "0.000" "False" "245.401" "25" "48" "72" "48" "2005" "226.2" "7.30" "237.55" "48" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "1.015" "1.028" "0.978" "0.970" "1.011" "0.951" "0.970" "0.996" "0.994" "6018.2" "6108.4" "6185.7" "5883.5" "5840.2" "6081.6" "5720.8" "5837.4" "5995.6" "5980.7" "" "" "" "" "" "" "" "" "" "" "4833.7" "4407.6" "4913.5" "3941.9" "4039.1" "4562.9" "4005.4" "4263.1" "5995.6" "4863.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547781430018805415" "False" "High" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "0.000" "False" "244.528" "54" "24" "108" "24" "505" "56.7" "6.35" "353.42" "24" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "Prion disease pathway" "4" "0" "0.950" "0.958" "0.903" "0.969" "0.987" "0.945" "0.991" "0.985" "0.961" "7910.3" "7517.7" "7575.1" "7146.9" "7662.7" "7806.2" "7471.5" "7838.8" "7795.3" "7602.5" "" "" "" "" "" "" "" "" "" "" "6353.5" "5424.5" "6017.1" "4788.4" "5299.6" "5856.8" "5231.1" "5724.7" "7795.3" "6182.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4155367153969888648" "False" "High" "IsMasterProtein" "Cont_P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "0.000" "True" "243.789" "54" "27" "61" "23" "584" "58.8" "5.21" "218.62" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "Formation of the cornified envelope" "" "2" "3" "0.543" "0.182" "0.383" "0.834" "1.047" "1.391" "0.753" "0.418" "0.702" "5947.2" "3230.3" "1082.9" "2276.1" "4961.9" "6224.1" "8271.0" "4475.6" "2483.8" "4173.6" "" "" "" "" "" "" "" "" "" "" "4776.7" "2330.9" "860.2" "1525.0" "3431.7" "4669.9" "5790.9" "3268.5" "2483.8" "3394.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262993958771163174" "False" "High" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "0.000" "False" "242.421" "70" "20" "117" "20" "338" "35.5" "8.68" "420.49" "20" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; O43682; P40926" "Mitochondrial protein degradation; Gluconeogenesis; Citric acid cycle (TCA cycle)" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; 7q11.23 distal copy number variation; TCA cycle (aka Krebs or citric acid cycle)" "10" "0" "0.973" "0.992" "0.951" "0.990" "0.989" "0.948" "0.952" "0.960" "0.978" "11975.3" "11647.7" "11878.5" "11386.6" "11857.9" "11838.6" "11347.7" "11405.7" "11501.4" "11715.9" "" "" "" "" "" "" "" "" "" "" "9618.4" "8404.7" "9435.5" "7629.0" "8201.0" "8882.3" "7945.1" "8329.6" "11501.4" "9527.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397536938893978881" "False" "High" "IsMasterProtein" "O43491" "Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1" "0.000" "False" "242.224" "39" "32" "68" "32" "1005" "112.5" "5.44" "231.69" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2037" "ENSG00000079819" "EPB41L2" "B4DHI8; E9PPD9; hsa:2037; O43491; Q5T4F0; Q68DV2" "Neurexins and neuroligins" "Splicing factor NOVA regulated synaptic proteins" "2" "0" "0.985" "0.961" "0.983" "0.971" "0.988" "0.998" "0.979" "1.021" "0.969" "5157.2" "5081.9" "4953.6" "5067.9" "5008.3" "5095.4" "5145.3" "5047.6" "5262.9" "4999.8" "" "" "" "" "" "" "" "" "" "" "4142.2" "3667.0" "3934.8" "3395.5" "3463.8" "3823.0" "3602.5" "3686.3" "5262.9" "4066.0" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2050551167936510610" "False" "High" "IsMasterProtein" "Q01813" "ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2" "0.000" "False" "241.579" "45" "29" "73" "26" "784" "85.5" "7.55" "263.83" "29" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5214" "ENSG00000067057" "PFKP" "B3KS15; hsa:5214; Q01813; Q5VSR7; Q5VSR8" "Glycolysis" "Cori cycle; Clear cell renal cell carcinoma pathways; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "4" "0.982" "1.028" "0.996" "0.982" "0.988" "0.952" "0.958" "0.904" "0.979" "6376.8" "6260.1" "6554.4" "6351.0" "6262.0" "6298.4" "6068.5" "6108.1" "5762.0" "6245.4" "" "" "" "" "" "" "" "" "" "" "5121.8" "4517.1" "5206.4" "4255.2" "4330.8" "4725.6" "4248.8" "4460.8" "5762.0" "5079.0" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819928772784180698" "False" "High" "IsMasterProtein" "Q03001" "Dystonin OS=Homo sapiens OX=9606 GN=DST PE=1 SV=4" "0.000" "False" "240.739" "7" "54" "62" "52" "7570" "860.1" "5.25" "200.44" "54" "cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "667" "ENSG00000151914" "DST" "B7Z3H1; E7ERU0; hsa:667; O94833; Q03001; Q12825; Q13266; Q13267; Q13775; Q5TBT0; Q5TBT2; Q5TF23; Q5TF24; Q8N1T8; Q8N8J3; Q8WXK8; Q8WXK9; Q96AK9; Q96DQ5; Q96J76; Q96QT5; Q9H555; Q9UGD7; Q9UGD8; Q9UN10" "RND1 GTPase cycle; RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; Type I hemidesmosome assembly" "" "6" "0" "1.018" "0.978" "0.977" "1.006" "1.018" "0.965" "0.987" "0.979" "1.002" "3634.7" "3698.9" "3556.3" "3551.3" "3654.7" "3701.1" "3506.7" "3586.1" "3556.7" "3640.6" "" "" "" "" "" "" "" "" "" "" "2919.4" "2669.0" "2824.9" "2379.4" "2527.6" "2776.8" "2455.2" "2618.9" "3556.7" "2960.7" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "454806171855366482" "False" "High" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "0.000" "False" "240.462" "42" "25" "68" "25" "763" "82.9" "9.04" "247.90" "25" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "13" "0" "1.027" "1.016" "0.957" "0.980" "0.974" "0.940" "1.016" "0.982" "0.993" "6389.7" "6562.9" "6489.5" "6113.5" "6261.9" "6225.9" "6005.1" "6493.2" "6276.1" "6348.0" "" "" "" "" "" "" "" "" "" "" "5132.1" "4735.6" "5154.8" "4096.0" "4330.8" "4671.2" "4204.4" "4742.0" "6276.1" "5162.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5988193438521902409" "False" "High" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "0.000" "False" "239.544" "31" "34" "76" "34" "1264" "140.4" "7.59" "256.99" "34" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Cytosolic tRNA aminoacylation" "Amino acid metabolism" "2" "0" "1.000" "0.984" "0.989" "1.007" "0.995" "0.979" "0.955" "0.981" "0.983" "4901.3" "4901.5" "4821.3" "4847.8" "4937.8" "4874.5" "4799.0" "4680.9" "4809.0" "4815.9" "" "" "" "" "" "" "" "" "" "" "3936.7" "3536.8" "3829.7" "3248.0" "3415.0" "3657.2" "3360.0" "3418.4" "4809.0" "3916.5" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528371413836643526" "False" "High" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "0.000" "False" "239.520" "44" "28" "91" "24" "711" "73.1" "7.30" "284.88" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "Pre-implantation embryo" "3" "4" "1.067" "1.029" "1.039" "1.021" "1.025" "1.005" "1.003" "1.012" "0.994" "7363.6" "7857.9" "7579.9" "7653.1" "7519.2" "7549.3" "7402.5" "7386.1" "7450.8" "7316.9" "" "" "" "" "" "" "" "" "" "" "5914.4" "5670.0" "6020.9" "5127.6" "5200.3" "5664.1" "5182.9" "5394.1" "7450.8" "5950.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547053484993874983" "False" "High" "IsMasterProtein" "Q13085" "Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2" "0.000" "False" "239.252" "27" "52" "65" "52" "2346" "265.4" "6.37" "207.62" "52" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf21385" "31" "ENSG00000275176; ENSG00000278540" "ACACA" "B2RP68; B2ZZ90; hsa:31; Q13085; Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3" "ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; Defective HLCS causes multiple carboxylase deficiency" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome; 17q12 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ADHD and autism (ASD) linked metabolic pathways and SNP" "24" "0" "1.010" "1.050" "1.015" "1.017" "1.013" "0.959" "1.043" "0.983" "1.016" "4969.8" "5020.9" "5220.2" "5046.4" "5055.8" "5035.4" "4766.8" "5183.8" "4887.5" "5048.8" "" "" "" "" "" "" "" "" "" "" "3991.7" "3623.0" "4146.5" "3381.1" "3496.6" "3778.0" "3337.5" "3785.8" "4887.5" "4105.9" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6011940264998513028" "False" "High" "IsMasterProtein" "O00429" "Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2" "0.000" "False" "239.169" "49" "35" "72" "35" "736" "81.8" "6.81" "241.93" "35" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "10059" "ENSG00000087470" "DNM1L" "A8K4X9; B4DGC9; B4DSU8; G8JLD5; hsa:10059; J3KPI2; O00429; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2" "Apoptotic execution phase" "Synaptic vesicle pathway; CAMKK2 pathway" "3" "0" "1.041" "1.011" "1.004" "1.005" "1.000" "0.974" "1.016" "1.029" "1.017" "5223.7" "5439.6" "5279.4" "5246.5" "5248.8" "5222.4" "5088.1" "5308.2" "5373.9" "5311.4" "" "" "" "" "" "" "" "" "" "" "4195.6" "3925.1" "4193.6" "3515.2" "3630.1" "3918.3" "3562.5" "3876.6" "5373.9" "4319.4" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8785242188080332383" "False" "High" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "0.000" "False" "237.198" "61" "28" "84" "28" "519" "56.1" "7.93" "292.72" "28" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "0.988" "0.995" "0.960" "0.938" "0.975" "0.937" "0.900" "0.939" "0.942" "8280.7" "8184.7" "8239.5" "7946.2" "7767.6" "8071.2" "7763.0" "7451.5" "7779.5" "7804.3" "" "" "" "" "" "" "" "" "" "" "6650.9" "5905.8" "6544.9" "5324.0" "5372.2" "6055.7" "5435.3" "5441.8" "7779.5" "6346.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199308046116639924" "False" "High" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "0.000" "False" "236.838" "31" "36" "68" "33" "1337" "150.7" "7.91" "238.34" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "0" "1.031" "1.011" "1.000" "1.012" "0.992" "0.993" "1.036" "1.013" "1.014" "5294.3" "5458.4" "5350.1" "5296.8" "5357.0" "5251.2" "5255.2" "5482.6" "5360.8" "5368.4" "" "" "" "" "" "" "" "" "" "" "4252.3" "3938.6" "4249.7" "3548.9" "3705.0" "3939.9" "3679.4" "4004.0" "5360.8" "4365.8" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612190288293860915" "False" "High" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "0.000" "False" "235.372" "60" "24" "102" "14" "406" "46.1" "5.48" "336.36" "24" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "13" "8" "1.020" "1.050" "1.019" "1.012" "1.001" "0.994" "1.018" "1.054" "1.023" "8145.7" "8312.2" "8555.7" "8299.1" "8246.9" "8152.3" "8098.4" "8290.0" "8586.0" "8334.1" "" "" "" "" "" "" "" "" "" "" "6542.6" "5997.8" "6796.1" "5560.4" "5703.6" "6116.5" "5670.1" "6054.2" "8586.0" "6777.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7238306351176714360" "False" "High" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "0.000" "False" "235.356" "36" "25" "80" "25" "876" "97.1" "4.78" "273.48" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Neutrophil degranulation; Apoptosis induced DNA fragmentation; Interferon alpha/beta signaling; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Assembly of the ORC complex at the origin of replication; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "15" "0" "1.009" "1.036" "0.974" "0.997" "0.984" "0.953" "1.025" "1.016" "1.002" "8716.7" "8792.1" "9028.5" "8494.3" "8693.4" "8579.6" "8310.8" "8930.4" "8853.0" "8730.2" "" "" "" "" "" "" "" "" "" "" "7001.2" "6344.1" "7171.6" "5691.2" "6012.4" "6437.2" "5818.8" "6521.9" "8853.0" "7099.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1675447815179810956" "False" "High" "IsMasterProtein" "Cont_P00883" "Fructose-bisphosphate aldolase A OS=Oryctolagus cuniculus OX=9986 GN=ALDOA PE=1 SV=2" "0.000" "True" "234.118" "55" "24" "139" "1" "364" "39.3" "8.09" "473.19" "24" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytoskeleton" "other molecular function" "Pf00274" "100009055" "ENSOCUG00000006329" "ALDOA" "ocu:100009055; P00883; Q28671" "" "" "0" "0" "0.805" "1.118" "1.134" "1.053" "0.961" "1.261" "1.000" "0.969" "1.024" "57.4" "46.2" "64.2" "65.1" "60.5" "55.2" "72.4" "57.4" "55.6" "58.8" "" "" "" "" "" "" "" "" "" "" "46.1" "33.4" "51.0" "43.6" "41.8" "41.4" "50.7" "41.9" "55.6" "47.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7881821209807726399" "False" "High" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "0.000" "False" "232.761" "32" "38" "64" "38" "1309" "146.6" "6.13" "220.44" "38" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "" "Translation factors" "1" "0" "1.028" "0.981" "1.000" "1.010" "1.020" "0.965" "0.973" "0.986" "1.004" "4810.1" "4945.4" "4720.1" "4811.0" "4856.4" "4905.8" "4640.4" "4680.5" "4743.3" "4827.2" "" "" "" "" "" "" "" "" "" "" "3863.4" "3568.5" "3749.3" "3223.4" "3358.7" "3680.7" "3249.0" "3418.2" "4743.3" "3925.6" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382790352375516909" "False" "High" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "0.000" "False" "232.316" "35" "35" "65" "35" "1217" "135.5" "5.26" "223.12" "35" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.066" "1.038" "1.020" "1.010" "1.042" "0.997" "0.973" "0.945" "1.016" "5964.2" "6359.5" "6191.2" "6086.4" "6023.4" "6215.9" "5945.5" "5800.8" "5637.1" "6062.5" "" "" "" "" "" "" "" "" "" "" "4790.4" "4588.8" "4917.9" "4077.9" "4165.8" "4663.7" "4162.7" "4236.4" "5637.1" "4930.2" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8891268094734712955" "False" "High" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "0.000" "False" "231.202" "28" "41" "79" "41" "1488" "152.0" "9.04" "233.61" "41" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "0.984" "1.020" "0.981" "0.972" "0.975" "0.912" "0.976" "0.970" "0.969" "5798.2" "5704.3" "5911.6" "5688.6" "5633.0" "5652.6" "5285.7" "5659.0" "5626.1" "5620.3" "" "" "" "" "" "" "" "" "" "" "4657.0" "4116.1" "4695.8" "3811.4" "3895.8" "4241.0" "3700.8" "4132.8" "5626.1" "4570.6" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2064522308959827201" "False" "High" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "0.000" "False" "230.509" "47" "33" "89" "26" "729" "80.2" "8.27" "272.06" "33" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "SUMOylation of transcription cofactors" "Novel intracellular components of RIG-I-like receptor pathway" "2" "7" "0.990" "0.980" "0.983" "0.981" "0.994" "0.999" "0.997" "0.988" "0.989" "7842.4" "7762.8" "7682.9" "7706.1" "7697.0" "7792.2" "7838.1" "7819.9" "7746.3" "7759.2" "" "" "" "" "" "" "" "" "" "" "6298.9" "5601.4" "6102.8" "5163.1" "5323.3" "5846.3" "5487.8" "5710.9" "7746.3" "6310.0" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778599060552415361" "False" "High" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "0.000" "False" "230.378" "49" "33" "123" "33" "730" "77.5" "8.70" "352.04" "33" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "4" "0" "1.083" "1.062" "1.084" "1.130" "1.069" "1.029" "1.084" "1.088" "1.079" "7265.3" "7868.3" "7712.3" "7877.4" "8211.3" "7766.9" "7477.6" "7876.5" "7906.0" "7837.0" "" "" "" "" "" "" "" "" "" "" "5835.4" "5677.6" "6126.1" "5277.9" "5679.0" "5827.4" "5235.4" "5752.3" "7906.0" "6373.3" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4218486089971029806" "False" "High" "IsMasterProtein" "Q92608" "Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2" "0.000" "False" "229.503" "27" "46" "76" "46" "1830" "211.8" "6.87" "225.26" "46" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "1794" "ENSG00000134516" "DOCK2" "hsa:1794; Q2M3I0; Q92608; Q96AK7" "Neutrophil degranulation; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOA GTPase cycle; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction" "Chemokine signaling pathway" "8" "0" "1.003" "0.994" "0.962" "0.956" "0.964" "0.917" "0.974" "0.937" "0.972" "5615.5" "5632.7" "5583.2" "5401.4" "5365.9" "5414.0" "5146.6" "5470.6" "5263.9" "5456.6" "" "" "" "" "" "" "" "" "" "" "4510.3" "4064.4" "4434.9" "3619.0" "3711.1" "4062.0" "3603.4" "3995.2" "5263.9" "4437.5" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625268949045148761" "False" "High" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "0.000" "False" "229.242" "36" "29" "68" "29" "923" "102.8" "5.22" "234.64" "29" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "Regulation of HSF1-mediated heat shock response" "TAR syndrome" "2" "0" "1.124" "1.028" "1.027" "1.014" "1.042" "1.000" "1.012" "1.007" "1.006" "5065.7" "5694.3" "5205.4" "5200.0" "5137.9" "5278.2" "5064.2" "5127.0" "5100.3" "5096.9" "" "" "" "" "" "" "" "" "" "" "4068.7" "4108.9" "4134.8" "3484.0" "3553.4" "3960.1" "3545.7" "3744.2" "5100.3" "4145.0" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93138434393619496" "False" "High" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "0.000" "False" "229.234" "28" "38" "71" "35" "1447" "164.6" "8.47" "236.71" "38" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "3" "1.013" "1.002" "0.999" "0.996" "0.986" "1.001" "1.058" "1.006" "1.000" "7471.2" "7569.6" "7483.8" "7460.6" "7440.5" "7364.0" "7476.7" "7903.9" "7516.3" "7467.9" "" "" "" "" "" "" "" "" "" "" "6000.8" "5462.0" "5944.6" "4998.6" "5145.9" "5525.1" "5234.8" "5772.2" "7516.3" "6073.1" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773459124454051332" "False" "High" "IsMasterProtein" "P49915" "GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1" "0.000" "False" "228.990" "47" "28" "67" "28" "693" "76.7" "6.87" "257.14" "28" "other metabolic processes" "cytosol" "other molecular function" "Pf00117, Pf00958, Pf02540" "8833" "ENSG00000163655" "GMPS" "A8K639; B4DXV7; F8W720; hsa:8833; P49915" "Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "" "2" "0" "1.000" "1.030" "0.958" "0.955" "0.971" "0.962" "1.014" "1.002" "0.973" "5915.4" "5914.0" "6095.7" "5669.5" "5649.4" "5745.8" "5692.2" "6000.6" "5925.8" "5756.3" "" "" "" "" "" "" "" "" "" "" "4751.1" "4267.4" "4842.0" "3798.6" "3907.2" "4311.0" "3985.4" "4382.2" "5925.8" "4681.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8484028389043526679" "False" "High" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "0.000" "False" "228.917" "45" "26" "74" "26" "732" "82.7" "5.81" "260.24" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network" "9" "0" "0.980" "1.004" "0.992" "1.034" "0.988" "1.007" "0.990" "0.990" "0.967" "5602.8" "5491.4" "5624.1" "5560.2" "5795.5" "5536.2" "5641.0" "5548.1" "5544.3" "5420.6" "" "" "" "" "" "" "" "" "" "" "4500.1" "3962.5" "4467.4" "3725.3" "4008.2" "4153.7" "3949.6" "4051.8" "5544.3" "4408.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6568070672358433938" "False" "High" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=3" "0.000" "False" "228.420" "37" "40" "67" "40" "1268" "141.4" "6.87" "216.11" "40" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "HDL clearance" "2q37 copy number variation syndrome" "2" "0" "1.006" "1.051" "1.042" "1.042" "1.007" "1.012" "1.060" "1.040" "1.029" "5455.3" "5485.4" "5732.3" "5683.0" "5684.5" "5494.6" "5520.9" "5784.5" "5672.5" "5611.0" "" "" "" "" "" "" "" "" "" "" "4381.6" "3958.1" "4553.3" "3807.6" "3931.4" "4122.5" "3865.4" "4224.4" "5672.5" "4563.1" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2868702294912813046" "False" "High" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4" "0.000" "False" "227.729" "84" "16" "166" "16" "249" "26.7" "6.90" "598.99" "16" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "7167" "ENSG00000111669" "TPI1" "B7Z5D8; D3DUS9; hsa:7167; P00938; P60174; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5" "Glycolysis; Gluconeogenesis" "Fatty acid beta-oxidation; Cori cycle; HIF1A and PPARG regulation of glycolysis; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "10" "0" "0.983" "1.000" "0.993" "1.031" "1.051" "1.020" "0.989" "1.005" "1.021" "11075.5" "10890.5" "11080.0" "11003.2" "11419.1" "11636.7" "11297.8" "10954.5" "11134.6" "11312.4" "" "" "" "" "" "" "" "" "" "" "8895.7" "7858.2" "8801.2" "7372.1" "7897.6" "8730.8" "7910.1" "8000.1" "11134.6" "9199.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740854368523393254" "False" "High" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "0.000" "False" "226.916" "43" "28" "55" "26" "783" "87.3" "9.28" "206.70" "28" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "10q11.21q11.23 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "4" "2" "1.009" "0.981" "0.943" "1.018" "0.991" "0.970" "1.012" "0.920" "0.970" "6779.2" "6842.4" "6647.6" "6390.3" "6897.8" "6716.2" "6576.0" "6861.9" "6238.3" "6578.7" "" "" "" "" "" "" "" "" "" "" "5445.0" "4937.3" "5280.4" "4281.5" "4770.6" "5039.0" "4604.2" "5011.3" "6238.3" "5350.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2914348929085593862" "False" "High" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "0.000" "False" "226.852" "35" "39" "74" "39" "1278" "148.3" "7.31" "221.55" "39" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "Fragile X syndrome; Regulation of actin cytoskeleton" "7" "0" "0.996" "1.032" "1.007" "1.038" "1.007" "0.970" "1.038" "1.007" "1.017" "5235.6" "5217.0" "5402.3" "5271.4" "5436.8" "5271.0" "5078.3" "5436.7" "5271.3" "5323.3" "" "" "" "" "" "" "" "" "" "" "4205.2" "3764.5" "4291.2" "3531.8" "3760.1" "3954.7" "3555.6" "3970.4" "5271.3" "4329.1" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2832146552711634492" "False" "High" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "0.000" "False" "226.564" "32" "28" "58" "28" "1023" "115.9" "6.86" "205.34" "28" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "1.009" "0.987" "1.026" "1.046" "1.034" "0.988" "1.030" "0.977" "1.044" "4561.0" "4600.8" "4503.1" "4679.7" "4772.0" "4714.4" "4506.3" "4697.5" "4455.7" "4761.9" "" "" "" "" "" "" "" "" "" "" "3663.4" "3319.8" "3576.9" "3135.4" "3300.3" "3537.1" "3155.1" "3430.6" "4455.7" "3872.6" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2402053168044673171" "False" "High" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "0.000" "False" "226.321" "55" "19" "80" "19" "529" "56.5" "5.40" "274.24" "19" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "8" "0" "1.012" "1.007" "1.051" "1.079" "1.099" "1.058" "1.059" "1.054" "1.033" "4796.5" "4851.7" "4831.9" "5039.1" "5173.9" "5272.6" "5073.0" "5080.6" "5053.9" "4953.0" "" "" "" "" "" "" "" "" "" "" "3852.5" "3500.9" "3838.1" "3376.2" "3578.3" "3956.0" "3551.9" "3710.4" "5053.9" "4027.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5119731611670534936" "False" "High" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "0.000" "False" "226.278" "29" "32" "59" "32" "1272" "141.3" "5.41" "201.86" "32" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "14" "0" "1.006" "0.995" "0.971" "0.967" "0.990" "0.982" "1.020" "1.018" "0.980" "6324.8" "6360.2" "6292.5" "6138.4" "6114.3" "6263.4" "6208.9" "6449.1" "6439.2" "6200.9" "" "" "" "" "" "" "" "" "" "" "5080.0" "4589.3" "4998.3" "4112.7" "4228.7" "4699.3" "4347.2" "4709.8" "6439.2" "5042.8" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3292354779633865334" "False" "High" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "0.000" "False" "225.949" "20" "43" "69" "43" "2376" "266.8" "7.11" "229.21" "43" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "Ciliary landscape" "4" "0" "1.036" "1.027" "1.020" "1.020" "1.011" "0.965" "1.026" "1.030" "1.008" "4820.1" "4995.6" "4951.8" "4916.4" "4917.0" "4872.7" "4653.4" "4947.2" "4965.8" "4860.9" "" "" "" "" "" "" "" "" "" "" "3871.5" "3604.7" "3933.4" "3294.0" "3400.6" "3655.9" "3258.1" "3612.9" "4965.8" "3953.1" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-729542664091126034" "False" "High" "IsMasterProtein" "Q93008" "Ubiquitin carboxyl-terminal hydrolase 9X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4" "0.000" "False" "225.411" "19" "44" "56" "22" "2554" "290.3" "5.80" "188.01" "44" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8239" "ENSG00000124486" "USP9X" "hsa:8239; O75550; Q8WWT3; Q8WX12; Q93008" "Ub-specific processing proteases; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Peroxisomal protein import; RHOV GTPase cycle; RHOU GTPase cycle" "Ciliopathies; Bardet-Biedl syndrome" "9" "14" "1.010" "1.043" "1.025" "0.981" "0.992" "0.973" "0.975" "0.977" "0.994" "5706.1" "5762.8" "5951.9" "5851.0" "5595.5" "5659.7" "5553.7" "5565.2" "5572.4" "5673.7" "" "" "" "" "" "" "" "" "" "" "4583.1" "4158.2" "4727.8" "3920.1" "3869.9" "4246.3" "3888.4" "4064.3" "5572.4" "4614.0" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5095696648215945885" "False" "High" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "0.000" "False" "225.315" "62" "20" "80" "14" "364" "39.4" "6.87" "296.36" "20" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "0" "1.015" "0.997" "1.028" "1.021" "1.015" "1.054" "1.006" "1.007" "1.004" "3316.2" "3364.7" "3305.6" "3409.5" "3386.8" "3365.8" "3494.0" "3336.4" "3338.1" "3330.2" "" "" "" "" "" "" "" "" "" "" "2663.5" "2427.9" "2625.7" "2284.4" "2342.4" "2525.3" "2446.3" "2436.6" "3338.1" "2708.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6444296704773161539" "False" "High" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "0.000" "False" "223.303" "58" "30" "75" "30" "589" "66.1" "6.84" "279.38" "30" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "Cytosolic tRNA aminoacylation" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "3" "0" "0.982" "0.975" "0.958" "0.972" "0.939" "0.932" "0.935" "0.923" "0.959" "6193.5" "6082.9" "6039.9" "5932.5" "6022.7" "5818.7" "5770.1" "5789.1" "5717.6" "5939.1" "" "" "" "" "" "" "" "" "" "" "4974.6" "4389.2" "4797.7" "3974.7" "4165.3" "4365.6" "4039.9" "4227.8" "5717.6" "4829.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656401588938308742" "False" "High" "IsMasterProtein" "Q14676" "Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3" "0.000" "False" "222.262" "19" "32" "47" "32" "2089" "226.5" "5.47" "181.64" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00498, Pf16589, Pf16770" "9656" "ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095" "MDC1" "A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of DNA damage response and repair proteins; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "9" "0" "1.044" "1.022" "1.029" "1.034" "1.004" "0.986" "0.962" "0.972" "0.985" "3353.0" "3499.7" "3425.8" "3449.4" "3467.6" "3367.4" "3304.9" "3225.7" "3259.0" "3301.9" "" "" "" "" "" "" "" "" "" "" "2693.1" "2525.3" "2721.2" "2311.1" "2398.3" "2526.5" "2313.9" "2355.7" "3259.0" "2685.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5794386193398091018" "False" "High" "IsMasterProtein" "Q9NY33" "Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2" "0.000" "False" "221.325" "46" "27" "54" "27" "737" "82.5" "5.10" "225.50" "27" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03571" "10072" "ENSG00000254986" "DPP3" "B2RDB5; B4DLX4; F5H8L6; hsa:10072; O95748; Q969H2; Q9BV67; Q9HAL6; Q9NY33" "Neddylation; KEAP1-NFE2L2 pathway" "" "2" "0" "0.967" "0.976" "0.961" "0.949" "0.960" "0.929" "0.928" "0.920" "0.961" "5291.8" "5117.2" "5166.1" "5087.4" "5019.8" "5080.6" "4915.3" "4910.9" "4869.2" "5085.9" "" "" "" "" "" "" "" "" "" "" "4250.3" "3692.4" "4103.6" "3408.5" "3471.7" "3811.9" "3441.4" "3586.5" "4869.2" "4136.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3988620745573507049" "False" "High" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "0.000" "False" "220.414" "34" "28" "58" "28" "919" "103.2" "5.72" "207.09" "28" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.994" "0.992" "0.956" "0.996" "1.013" "0.979" "1.000" "0.955" "0.998" "6389.8" "6352.4" "6337.4" "6106.2" "6362.7" "6469.7" "6254.8" "6392.0" "6103.7" "6375.5" "" "" "" "" "" "" "" "" "" "" "5132.2" "4583.7" "5034.0" "4091.2" "4400.5" "4854.1" "4379.3" "4668.1" "6103.7" "5184.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7845595134204648988" "False" "High" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "0.000" "False" "220.147" "38" "26" "55" "26" "845" "95.9" "6.80" "194.34" "26" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "ABC-family proteins mediated transport" "IL-18 signaling pathway" "2" "0" "1.047" "1.014" "1.054" "1.050" "1.010" "1.062" "1.051" "1.047" "1.021" "4374.5" "4581.5" "4435.2" "4612.3" "4593.6" "4417.8" "4645.8" "4598.1" "4579.1" "4467.3" "" "" "" "" "" "" "" "" "" "" "3513.5" "3305.9" "3523.0" "3090.2" "3177.0" "3314.6" "3252.8" "3358.0" "4579.1" "3633.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604627173476332081" "False" "High" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "0.000" "False" "219.866" "45" "33" "66" "33" "798" "88.8" "6.25" "227.13" "33" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "1.015" "1.033" "0.984" "0.967" "1.001" "0.972" "0.966" "0.959" "0.971" "7846.4" "7966.0" "8101.6" "7717.3" "7589.9" "7855.3" "7629.5" "7576.2" "7521.5" "7619.1" "" "" "" "" "" "" "" "" "" "" "6302.2" "5748.0" "6435.4" "5170.6" "5249.2" "5893.7" "5341.8" "5532.9" "7521.5" "6196.1" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994958122545782914" "False" "High" "IsMasterProtein" "Cont_Q9XSJ4" "Alpha-enolase OS=Bos taurus OX=9913 GN=ENO1 PE=1 SV=4" "0.000" "True" "219.822" "51" "18" "213" "1" "434" "47.3" "6.80" "693.10" "18" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "281141" "" "ENO1" "bta:281141; Q3SYW4; Q9XSJ4" "" "" "0" "2" "1.016" "1.049" "1.193" "1.143" "0.973" "1.047" "0.972" "1.050" "1.140" "351.9" "357.7" "369.1" "419.9" "402.2" "342.4" "368.5" "342.0" "369.5" "401.0" "" "" "" "" "" "" "" "" "" "" "282.6" "258.1" "293.2" "281.4" "278.2" "256.9" "258.0" "249.8" "369.5" "326.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-515522588376759980" "False" "High" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "0.000" "False" "219.482" "45" "25" "89" "17" "623" "69.6" "8.59" "306.31" "25" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "7" "1.005" "1.048" "0.966" "0.974" "1.026" "0.942" "0.986" "0.985" "1.016" "7537.0" "7577.6" "7896.2" "7284.1" "7337.7" "7732.7" "7101.6" "7433.8" "7423.2" "7656.6" "" "" "" "" "" "" "" "" "" "" "6053.7" "5467.8" "6272.2" "4880.4" "5074.8" "5801.7" "4972.2" "5428.9" "7423.2" "6226.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964707792463719030" "False" "High" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "0.000" "False" "218.356" "46" "21" "64" "21" "548" "62.9" "6.25" "226.64" "21" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf20917" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Cytosolic tRNA aminoacylation" "Photodynamic therapy-induced unfolded protein response" "2" "0" "1.011" "1.023" "1.025" "1.049" "1.061" "1.049" "1.027" "1.041" "1.041" "4934.8" "4989.0" "5047.7" "5057.7" "5175.9" "5233.5" "5175.2" "5070.4" "5136.3" "5135.9" "" "" "" "" "" "" "" "" "" "" "3963.6" "3599.9" "4009.6" "3388.6" "3579.7" "3926.6" "3623.4" "3702.9" "5136.3" "4176.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6445951316860718443" "False" "High" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0.000" "False" "218.326" "30" "32" "47" "30" "1298" "146.5" "7.01" "174.86" "32" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "4" "0" "1.034" "1.029" "1.021" "0.984" "1.020" "0.962" "0.997" "1.026" "1.032" "2828.0" "2925.6" "2909.3" "2886.8" "2781.9" "2884.2" "2720.1" "2819.2" "2901.7" "2919.2" "" "" "" "" "" "" "" "" "" "" "2271.4" "2111.0" "2310.9" "1934.1" "1924.0" "2163.9" "1904.5" "2058.9" "2901.7" "2374.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-719373628240286726" "False" "High" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "0.000" "False" "217.658" "68" "26" "59" "26" "422" "47.4" "6.48" "220.31" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "63" "0" "0.967" "0.993" "0.947" "0.961" "0.953" "0.977" "0.983" "0.953" "0.974" "6971.1" "6737.6" "6925.1" "6599.6" "6697.1" "6643.3" "6809.6" "6851.2" "6641.1" "6789.9" "" "" "" "" "" "" "" "" "" "" "5599.1" "4861.7" "5500.9" "4421.7" "4631.8" "4984.3" "4767.7" "5003.4" "6641.1" "5521.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535556334998408323" "False" "High" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=3" "0.000" "False" "217.006" "53" "21" "91" "21" "455" "49.8" "7.61" "335.37" "21" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "7284" "ENSG00000178952" "TUFM" "hsa:7284; O15276; P49411" "Mitochondrial translation elongation; SARS-CoV-2 modulates autophagy" "16p11.2 distal deletion syndrome" "3" "0" "0.984" "1.023" "0.972" "0.953" "0.973" "0.916" "0.940" "0.938" "0.954" "8113.1" "7979.3" "8299.1" "7881.9" "7727.8" "7893.9" "7431.7" "7622.3" "7607.1" "7739.4" "" "" "" "" "" "" "" "" "" "" "6516.3" "5757.7" "6592.3" "5280.9" "5344.6" "5922.6" "5203.3" "5566.6" "7607.1" "6294.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1511702505276588775" "False" "High" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "0.000" "False" "216.878" "45" "26" "95" "25" "704" "80.1" "8.21" "340.97" "26" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "Respiratory electron transport" "TNF-alpha signaling pathway; TGF-beta signaling pathway; Clock-controlled autophagy in bone metabolism" "4" "0" "1.055" "1.019" "1.011" "1.046" "1.005" "0.983" "1.041" "1.002" "1.004" "5164.1" "5445.8" "5263.4" "5220.0" "5401.0" "5192.3" "5075.1" "5376.3" "5176.9" "5183.0" "" "" "" "" "" "" "" "" "" "" "4147.8" "3929.5" "4180.9" "3497.4" "3735.4" "3895.7" "3553.3" "3926.3" "5176.9" "4215.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835450799000805125" "False" "High" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "0.000" "False" "216.351" "45" "34" "70" "34" "819" "93.4" "5.72" "228.98" "34" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "HCMV Early Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "1.037" "1.026" "1.048" "1.022" "1.025" "1.018" "1.113" "1.087" "1.052" "4762.4" "4936.4" "4887.2" "4990.3" "4866.1" "4881.8" "4849.8" "5302.2" "5177.0" "5010.3" "" "" "" "" "" "" "" "" "" "" "3825.1" "3562.0" "3882.0" "3343.5" "3365.4" "3662.8" "3395.6" "3872.2" "5177.0" "4074.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171365705039643338" "False" "High" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "0.000" "False" "215.434" "35" "27" "66" "27" "858" "95.7" "5.03" "237.82" "27" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases" "IL-18 signaling pathway" "3" "0" "0.991" "1.006" "0.991" "1.022" "1.008" "0.987" "1.003" "0.983" "0.990" "5146.1" "5098.4" "5175.6" "5101.9" "5260.7" "5186.4" "5077.7" "5160.2" "5057.6" "5092.6" "" "" "" "" "" "" "" "" "" "" "4133.3" "3678.9" "4111.1" "3418.3" "3638.4" "3891.3" "3555.1" "3768.5" "5057.6" "4141.5" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5783897718523636057" "False" "High" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "0.000" "False" "214.503" "26" "38" "55" "37" "1720" "194.7" "7.03" "187.82" "38" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "1.013" "1.016" "1.048" "0.995" "1.001" "1.014" "1.014" "0.966" "1.021" "4523.3" "4581.2" "4595.9" "4739.2" "4500.7" "4527.5" "4585.4" "4586.9" "4370.2" "4616.8" "" "" "" "" "" "" "" "" "" "" "3633.1" "3305.6" "3650.7" "3175.3" "3112.8" "3396.9" "3210.5" "3349.8" "4370.2" "3754.6" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521793610303513807" "False" "High" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "0.000" "False" "213.252" "44" "32" "58" "30" "917" "102.3" "6.05" "190.95" "32" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Glycolysis" "Clear cell renal cell carcinoma pathways; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "7" "2" "1.033" "1.017" "1.015" "1.009" "1.004" "1.013" "0.936" "0.947" "0.980" "4429.5" "4574.9" "4504.9" "4495.3" "4467.5" "4448.9" "4485.5" "4145.6" "4195.1" "4343.0" "" "" "" "" "" "" "" "" "" "" "3557.7" "3301.1" "3578.4" "3011.9" "3089.7" "3337.9" "3140.5" "3027.5" "4195.1" "3531.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445993330794884217" "False" "High" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "0.000" "False" "212.940" "57" "30" "83" "30" "528" "59.1" "7.05" "283.10" "30" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Cytosolic tRNA aminoacylation" "Nephrotic syndrome" "2" "0" "0.985" "1.002" "0.926" "0.967" "0.961" "0.932" "0.959" "0.948" "0.961" "8569.4" "8441.0" "8586.7" "7931.4" "8288.5" "8236.4" "7982.4" "8218.7" "8122.3" "8235.7" "" "" "" "" "" "" "" "" "" "" "6882.8" "6090.8" "6820.7" "5314.1" "5732.4" "6179.6" "5588.9" "6002.2" "8122.3" "6697.6" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2749950876556130584" "False" "High" "IsMasterProtein" "P0DMV9" "Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1" "0.000" "False" "212.838" "53" "28" "95" "12" "641" "70.0" "5.66" "314.96" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3303; 3304" "ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804" "HSPA1B" "B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0" "Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection" "12" "7" "0.958" "0.948" "0.958" "0.986" "0.919" "1.083" "1.086" "1.064" "0.982" "4077.2" "3906.7" "3863.6" "3906.6" "4022.1" "3748.5" "4416.4" "4429.1" "4339.9" "4004.1" "" "" "" "" "" "" "" "" "" "" "3274.8" "2819.0" "3069.0" "2617.4" "2781.7" "2812.5" "3092.1" "3234.6" "4339.9" "3256.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "627927697280554035" "False" "High" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "0.000" "False" "212.381" "29" "36" "57" "36" "1220" "138.7" "5.49" "189.84" "36" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf11987, Pf14578" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; Ciliary landscape" "3" "0" "0.897" "1.010" "0.956" "0.902" "0.986" "0.971" "0.958" "0.947" "0.949" "6697.1" "6005.6" "6762.6" "6405.2" "6039.4" "6606.4" "6503.4" "6418.4" "6345.3" "6355.3" "" "" "" "" "" "" "" "" "" "" "5379.1" "4333.5" "5371.8" "4291.5" "4176.9" "4956.6" "4553.3" "4687.4" "6345.3" "5168.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630001761870027344" "False" "High" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "0.000" "False" "212.272" "59" "24" "95" "23" "504" "56.0" "8.53" "300.08" "24" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "RHOG GTPase cycle; Mitochondrial protein degradation; Metabolism of folate and pterines" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders" "13" "1" "0.973" "0.981" "0.958" "1.024" "0.993" "0.943" "0.946" "0.918" "0.971" "6267.7" "6096.4" "6151.2" "6002.2" "6416.0" "6225.0" "5910.1" "5931.5" "5755.2" "6087.5" "" "" "" "" "" "" "" "" "" "" "5034.2" "4399.0" "4886.1" "4021.5" "4437.3" "4670.5" "4138.0" "4331.8" "5755.2" "4950.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3930283768056647308" "False" "High" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "0.000" "False" "211.667" "55" "33" "108" "33" "543" "62.6" "6.80" "314.68" "33" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "VEGFA-VEGFR2 signaling" "3" "0" "1.039" "1.069" "1.009" "0.965" "1.054" "1.008" "1.002" "1.058" "1.019" "8438.9" "8765.9" "9021.5" "8515.6" "8139.6" "8895.0" "8507.4" "8459.5" "8928.2" "8600.8" "" "" "" "" "" "" "" "" "" "" "6778.1" "6325.2" "7166.1" "5705.4" "5629.4" "6673.8" "5956.4" "6178.0" "8928.2" "6994.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4752916691292977805" "False" "High" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "0.000" "False" "210.920" "45" "30" "56" "30" "778" "88.0" "6.80" "199.42" "30" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "1.008" "1.028" "0.961" "0.985" "1.008" "0.983" "1.014" "1.017" "1.007" "4609.7" "4647.8" "4737.8" "4427.8" "4540.3" "4646.0" "4532.5" "4674.1" "4687.6" "4640.1" "" "" "" "" "" "" "" "" "" "" "3702.5" "3353.7" "3763.3" "2966.6" "3140.1" "3485.8" "3173.4" "3413.5" "4687.6" "3773.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2399497510241032173" "False" "High" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "0.000" "False" "209.604" "54" "26" "64" "26" "553" "59.7" "9.13" "227.65" "26" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "7" "0" "0.955" "0.976" "1.042" "1.031" "0.996" "1.042" "1.036" "0.964" "0.970" "4933.6" "4709.5" "4816.0" "5141.6" "5085.1" "4916.2" "5143.1" "5109.1" "4753.7" "4785.4" "" "" "" "" "" "" "" "" "" "" "3962.6" "3398.3" "3825.5" "3444.8" "3516.9" "3688.6" "3600.9" "3731.2" "4753.7" "3891.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4230777369959258810" "False" "High" "IsMasterProtein" "O95239" "Chromosome-associated kinesin KIF4A OS=Homo sapiens OX=9606 GN=KIF4A PE=1 SV=3" "0.000" "False" "209.136" "29" "33" "55" "32" "1232" "139.8" "6.27" "183.87" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "24137" "ENSG00000090889" "KIF4A" "B2R7V5; D3DVU4; hsa:24137; O95239; Q86TN3; Q86XX7; Q9NNY6; Q9NY24; Q9UMW3" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "Retinoblastoma gene in cancer" "5" "1" "1.001" "0.993" "1.029" "1.004" "0.967" "0.959" "1.005" "0.988" "0.991" "4299.3" "4303.5" "4269.2" "4423.3" "4318.2" "4157.7" "4121.5" "4318.9" "4249.4" "4261.9" "" "" "" "" "" "" "" "" "" "" "3453.2" "3105.3" "3391.1" "2963.6" "2986.5" "3119.4" "2885.7" "3154.1" "4249.4" "3465.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2158743068394578481" "False" "High" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "0.000" "False" "208.525" "42" "21" "89" "21" "623" "67.8" "7.66" "317.93" "21" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "7" "0" "0.971" "1.001" "0.950" "0.935" "0.968" "0.892" "0.924" "0.957" "0.949" "8256.4" "8018.6" "8262.2" "7846.4" "7718.2" "7993.7" "7363.4" "7625.7" "7902.4" "7838.2" "" "" "" "" "" "" "" "" "" "" "6631.5" "5786.0" "6562.9" "5257.1" "5338.0" "5997.6" "5155.5" "5569.0" "7902.4" "6374.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7978508680545557598" "False" "High" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "0.000" "False" "207.966" "43" "26" "66" "26" "747" "85.1" "4.91" "211.63" "26" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "1.002" "1.020" "0.960" "0.966" "0.974" "1.025" "1.081" "1.054" "1.001" "5677.9" "5687.8" "5789.0" "5452.1" "5487.3" "5531.3" "5822.2" "6135.7" "5986.8" "5682.6" "" "" "" "" "" "" "" "" "" "" "4560.5" "4104.1" "4598.4" "3652.9" "3795.0" "4150.0" "4076.4" "4480.9" "5986.8" "4621.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7048585715635486560" "False" "High" "IsMasterProtein" "Q13885" "Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1" "0.000" "False" "207.949" "55" "18" "211" "1" "445" "49.9" "4.89" "603.71" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7280" "ENSG00000137267" "TUBB2A" "hsa:7280; Q13885; Q6FGZ8; Q8IWR2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; MHC class II antigen presentation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "35" "1" "1.123" "0.953" "0.872" "1.034" "0.939" "0.868" "1.030" "1.139" "1.066" "524.8" "589.5" "500.4" "457.6" "542.8" "492.7" "455.7" "540.7" "597.9" "559.2" "" "" "" "" "" "" "" "" "" "" "421.5" "425.4" "397.5" "306.6" "375.4" "369.7" "319.0" "394.8" "597.9" "454.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6681537936157474887" "False" "High" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "0.000" "False" "207.889" "53" "32" "72" "31" "585" "69.0" "5.87" "242.88" "32" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle" "" "3" "0" "0.983" "0.992" "0.983" "0.977" "0.980" "0.967" "0.982" "1.013" "0.937" "6140.3" "6033.1" "6091.8" "6037.1" "5999.2" "6019.4" "5937.9" "6030.2" "6219.7" "5751.8" "" "" "" "" "" "" "" "" "" "" "4931.8" "4353.3" "4838.9" "4044.8" "4149.1" "4516.2" "4157.4" "4403.9" "6219.7" "4677.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8217852517475646555" "False" "High" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "0.000" "False" "207.734" "44" "35" "69" "35" "944" "103.0" "6.07" "209.37" "35" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "1.007" "0.973" "1.000" "0.987" "0.975" "1.001" "0.988" "0.999" "0.997" "6463.8" "6508.5" "6289.8" "6465.0" "6381.9" "6303.3" "6469.0" "6387.0" "6457.5" "6445.3" "" "" "" "" "" "" "" "" "" "" "5191.7" "4696.3" "4996.2" "4331.6" "4413.8" "4729.3" "4529.3" "4664.4" "6457.5" "5241.5" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "964900113043376779" "False" "High" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "0.000" "False" "206.545" "58" "19" "62" "19" "456" "50.2" "6.42" "209.08" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "Ub-specific processing proteases; UCH proteinases; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; HATs acetylate histones; DNA Damage Recognition in GG-NER" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "9" "0" "1.017" "1.038" "1.014" "0.979" "0.962" "0.951" "0.981" "0.958" "0.986" "5098.3" "5184.4" "5289.8" "5170.2" "4989.8" "4906.8" "4846.2" "5002.4" "4886.1" "5028.8" "" "" "" "" "" "" "" "" "" "" "4094.9" "3740.9" "4201.9" "3464.0" "3451.0" "3681.5" "3393.1" "3653.3" "4886.1" "4089.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4934809763916306973" "False" "High" "IsMasterProtein" "Q6ZS81" "WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3" "0.000" "False" "206.451" "14" "35" "42" "35" "3184" "353.4" "6.32" "143.07" "35" "other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf00400, Pf02138" "57705" "ENSG00000128815" "WDFY4" "B9ZVP2; hsa:57705; Q6ZS81; Q86WZ4; Q8N4A3; Q8TEN7; Q96BE1; Q9H7H8; Q9HCG5" "" "10q11.21q11.23 copy number variation syndrome" "1" "0" "1.050" "1.016" "1.085" "1.041" "1.042" "1.017" "1.031" "0.982" "1.021" "2262.8" "2375.7" "2299.6" "2455.3" "2355.4" "2358.5" "2300.9" "2331.9" "2221.3" "2310.1" "" "" "" "" "" "" "" "" "" "" "1817.5" "1714.2" "1826.6" "1645.0" "1629.0" "1769.6" "1611.0" "1703.0" "2221.3" "1878.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5104969040472016970" "False" "High" "IsMasterProtein" "Q13576" "Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4" "0.000" "False" "206.268" "26" "35" "43" "35" "1575" "180.5" "5.64" "154.93" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "10788" "ENSG00000145703" "IQGAP2" "A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576" "Neutrophil degranulation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases activate IQGAPs" "Ciliary landscape; G13 signaling pathway" "7" "0" "1.023" "1.029" "0.997" "0.992" "1.007" "0.968" "0.984" "0.985" "1.039" "3495.2" "3575.3" "3595.7" "3486.3" "3465.8" "3518.2" "3383.0" "3439.9" "3442.3" "3630.2" "" "" "" "" "" "" "" "" "" "" "2807.3" "2579.8" "2856.2" "2335.8" "2396.9" "2639.7" "2368.6" "2512.2" "3442.3" "2952.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2329486021897558917" "False" "High" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "0.000" "False" "206.182" "31" "28" "77" "28" "998" "112.3" "6.39" "276.26" "28" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "3" "0" "1.010" "1.008" "1.023" "1.012" "0.975" "0.985" "1.011" "0.987" "0.991" "8833.0" "8918.1" "8900.6" "9036.6" "8940.2" "8611.8" "8701.2" "8930.1" "8721.2" "8754.8" "" "" "" "" "" "" "" "" "" "" "7094.6" "6435.0" "7070.0" "6054.5" "6183.1" "6461.3" "6092.1" "6521.7" "8721.2" "7119.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6687870354662644574" "False" "High" "IsMasterProtein" "Q8N3D4" "EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2" "0.000" "False" "205.973" "26" "26" "33" "26" "1523" "161.8" "4.83" "142.76" "26" "" "other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "254102" "ENSG00000173442" "EHBP1L1" "hsa:254102; Q8N3D4; Q8TB89; Q9H7M7" "" "" "0" "0" "1.025" "0.976" "1.054" "1.033" "0.974" "1.055" "1.064" "1.072" "1.021" "2014.2" "2064.7" "1965.8" "2123.3" "2081.4" "1961.0" "2125.8" "2143.9" "2160.2" "2056.8" "" "" "" "" "" "" "" "" "" "" "1617.7" "1489.8" "1561.5" "1422.6" "1439.5" "1471.3" "1488.4" "1565.7" "2160.2" "1672.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3565723958770546681" "False" "High" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "0.000" "False" "205.007" "28" "35" "43" "35" "1498" "167.3" "5.44" "166.07" "35" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "RND2 GTPase cycle" "" "1" "0" "1.016" "0.955" "1.036" "1.052" "1.006" "1.027" "0.964" "1.025" "1.004" "3776.2" "3835.3" "3606.5" "3913.0" "3971.1" "3797.2" "3878.4" "3640.9" "3870.9" "3791.3" "" "" "" "" "" "" "" "" "" "" "3033.0" "2767.4" "2864.8" "2621.7" "2746.5" "2849.0" "2715.5" "2658.9" "3870.9" "3083.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256091368978195991" "False" "High" "IsMasterProtein" "Q32MZ4" "Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2" "0.000" "False" "204.952" "32" "23" "51" "22" "808" "89.2" "4.65" "192.59" "23" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09738" "9208" "ENSG00000124831" "LRRFIP1" "E9PGZ2; hsa:9208; O75766; O75799; Q32MZ4; Q32MZ5; Q53T49; Q6PKG2; Q9Y607" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "IL-18 signaling pathway; 2q37 copy number variation syndrome" "5" "1" "1.027" "1.038" "1.048" "1.017" "1.052" "1.044" "1.075" "1.051" "1.012" "4438.2" "4558.4" "4606.6" "4652.6" "4514.9" "4668.6" "4632.1" "4769.6" "4666.7" "4490.3" "" "" "" "" "" "" "" "" "" "" "3564.7" "3289.2" "3659.2" "3117.2" "3122.6" "3502.7" "3243.1" "3483.3" "4666.7" "3651.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8235165147539186554" "False" "High" "IsMasterProtein" "Q16666" "Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3" "0.000" "False" "204.732" "41" "27" "68" "23" "785" "88.2" "9.28" "220.35" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "3428" "ENSG00000163565" "IFI16" "A0A346JEQ3; B4DJT8; H3BLV7; hsa:3428; Q16666; Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; Q9UH78" "IRF3-mediated induction of type I IFN" "" "2" "5" "0.995" "0.996" "0.992" "0.987" "0.952" "0.915" "0.948" "0.948" "0.972" "6921.1" "6884.6" "6893.2" "6867.4" "6829.2" "6592.2" "6331.9" "6557.9" "6564.2" "6728.9" "" "" "" "" "" "" "" "" "" "" "5558.9" "4967.7" "5475.5" "4601.2" "4723.1" "4946.0" "4433.3" "4789.2" "6564.2" "5472.2" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4912222715256496910" "False" "High" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "0.000" "False" "204.198" "43" "23" "80" "15" "633" "70.9" "8.13" "279.49" "23" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "1.058" "1.099" "0.982" "1.051" "1.028" "0.941" "1.025" "1.052" "1.054" "3549.5" "3754.7" "3899.6" "3487.4" "3730.1" "3648.1" "3341.1" "3637.8" "3733.7" "3741.7" "" "" "" "" "" "" "" "" "" "" "2850.9" "2709.3" "3097.6" "2336.5" "2579.7" "2737.1" "2339.3" "2656.7" "3733.7" "3042.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2468696703933973892" "False" "High" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "0.000" "False" "203.338" "33" "23" "56" "23" "792" "90.0" "7.15" "198.09" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Interconversion of nucleotide di- and triphosphates" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "4" "0" "0.971" "1.000" "0.929" "0.970" "0.993" "1.017" "1.062" "1.050" "1.008" "5547.8" "5386.9" "5545.6" "5152.2" "5381.8" "5508.9" "5643.2" "5889.5" "5827.7" "5591.0" "" "" "" "" "" "" "" "" "" "" "4455.9" "3887.1" "4405.1" "3452.0" "3722.1" "4133.2" "3951.0" "4301.1" "5827.7" "4546.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1477701677307109055" "False" "High" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "0.000" "False" "203.220" "40" "23" "55" "23" "616" "68.1" "7.21" "192.27" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "SUMOylation of DNA damage response and repair proteins; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "38" "0" "0.991" "0.999" "0.962" "0.955" "0.976" "0.957" "1.012" "1.004" "0.985" "6247.3" "6191.3" "6241.0" "6011.0" "5967.2" "6100.1" "5977.9" "6321.4" "6273.2" "6153.3" "" "" "" "" "" "" "" "" "" "" "5017.8" "4467.5" "4957.5" "4027.3" "4126.9" "4576.8" "4185.4" "4616.5" "6273.2" "5004.0" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469021931412063719" "False" "High" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "0.000" "False" "202.950" "39" "30" "66" "30" "953" "107.1" "6.05" "204.58" "30" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Neutrophil degranulation" "" "3" "0" "0.991" "1.006" "0.997" "0.977" "0.986" "0.965" "1.017" "0.983" "1.017" "4336.9" "4299.5" "4362.7" "4325.9" "4236.1" "4274.6" "4186.6" "4409.7" "4261.5" "4409.8" "" "" "" "" "" "" "" "" "" "" "3483.3" "3102.4" "3465.4" "2898.3" "2929.7" "3207.1" "2931.2" "3220.4" "4261.5" "3586.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250102899765152791" "False" "High" "IsMasterProtein" "Q9BVA1" "Tubulin beta-2B chain OS=Homo sapiens OX=9606 GN=TUBB2B PE=1 SV=1" "0.000" "False" "202.790" "55" "18" "210" "1" "445" "49.9" "4.89" "597.68" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "347733" "ENSG00000137285" "TUBB2B" "A8K068; hsa:347733; Q9BVA1" "Recruitment of NuMA to mitotic centrosomes; MHC class II antigen presentation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recycling pathway of L1; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "35" "0" "0.812" "1.087" "0.712" "1.168" "1.259" "0.936" "1.528" "1.390" "1.142" "124.4" "100.9" "135.1" "88.6" "145.2" "156.5" "116.5" "190.0" "172.8" "142.1" "" "" "" "" "" "" "" "" "" "" "99.9" "72.8" "107.3" "59.3" "100.4" "117.4" "81.5" "138.8" "172.8" "115.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1213395878895108528" "False" "High" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "0.000" "False" "202.722" "49" "36" "107" "28" "577" "67.8" "6.40" "314.55" "36" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by ALK fusions and activated point mutants" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "10" "7" "0.953" "0.949" "0.964" "1.012" "1.016" "1.033" "0.975" "0.990" "0.960" "10073.4" "9600.4" "9558.4" "9712.1" "10190.8" "10236.2" "10404.0" "9818.8" "9977.2" "9669.1" "" "" "" "" "" "" "" "" "" "" "8090.9" "6927.4" "7592.5" "6507.1" "7048.0" "7680.0" "7284.3" "7170.7" "9977.2" "7863.3" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4107495286689168051" "False" "High" "IsMasterProtein" "P42566" "Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2" "0.000" "False" "202.035" "36" "27" "43" "27" "896" "98.6" "4.64" "155.41" "27" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "" "2060" "ENSG00000085832" "EPS15" "B2R8J7; D3DPJ2; hsa:2060; P42566; Q5SRH4" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; EGF/EGFR signaling pathway" "8" "0" "1.014" "0.960" "1.007" "1.014" "0.980" "0.994" "1.004" "1.001" "0.979" "4382.6" "4441.8" "4205.7" "4413.5" "4444.8" "4297.1" "4354.5" "4399.5" "4387.5" "4289.6" "" "" "" "" "" "" "" "" "" "" "3520.1" "3205.1" "3340.7" "2957.1" "3074.1" "3224.1" "3048.8" "3213.0" "4387.5" "3488.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405025144750981774" "False" "High" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "0.000" "False" "201.844" "38" "39" "62" "39" "1056" "119.1" "5.64" "203.35" "39" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "" "3" "0" "1.010" "1.028" "0.993" "0.965" "0.964" "1.096" "1.165" "1.164" "1.052" "5416.3" "5471.2" "5567.0" "5375.9" "5228.3" "5221.7" "5937.8" "6311.1" "6302.0" "5700.0" "" "" "" "" "" "" "" "" "" "" "4350.3" "3947.9" "4422.1" "3601.9" "3615.9" "3917.8" "4157.3" "4609.0" "6302.0" "4635.5" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7970699774180839953" "False" "High" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "0.000" "False" "201.720" "61" "25" "68" "25" "463" "51.1" "5.64" "227.11" "25" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "HATs acetylate histones; Telomere Extension By Telomerase" "" "2" "0" "1.017" "1.038" "0.975" "0.966" "0.982" "0.913" "0.978" "0.968" "0.965" "7111.1" "7229.2" "7378.9" "6933.0" "6868.1" "6983.5" "6493.6" "6953.0" "6885.4" "6865.1" "" "" "" "" "" "" "" "" "" "" "5711.6" "5216.4" "5861.3" "4645.1" "4750.0" "5239.6" "4546.5" "5077.8" "6885.4" "5583.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-291186294764485320" "False" "High" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "0.000" "False" "201.165" "52" "30" "69" "30" "719" "81.3" "6.46" "234.71" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "12" "0" "1.010" "1.032" "1.009" "1.010" "0.975" "0.997" "1.055" "1.030" "1.010" "5084.7" "5136.6" "5247.0" "5128.1" "5134.4" "4959.4" "5068.9" "5362.2" "5239.0" "5134.8" "" "" "" "" "" "" "" "" "" "" "4084.0" "3706.4" "4167.9" "3435.8" "3551.0" "3720.9" "3549.0" "3916.1" "5239.0" "4175.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4532618803689773049" "False" "High" "IsMasterProtein" "P00491" "Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2" "0.000" "False" "200.969" "66" "15" "72" "15" "289" "32.1" "6.95" "247.85" "15" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf01048" "4860" "ENSG00000198805; ENSG00000291814" "PNP" "B2R8S5; D3DS00; hsa:4860; P00491; Q15160; Q5PZ03" "Neutrophil degranulation; Purine catabolism; Ribavirin ADME; Purine salvage; Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine" "VEGFA-VEGFR2 signaling" "6" "0" "1.010" "1.024" "1.003" "1.006" "1.038" "0.980" "0.981" "0.981" "1.030" "4524.1" "4568.3" "4630.7" "4539.6" "4551.7" "4694.5" "4435.4" "4439.4" "4438.0" "4661.1" "" "" "" "" "" "" "" "" "" "" "3633.7" "3296.4" "3678.3" "3041.5" "3148.0" "3522.2" "3105.4" "3242.1" "4438.0" "3790.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4784462983212685670" "False" "High" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "0.000" "False" "200.955" "57" "20" "62" "20" "475" "52.8" "5.97" "229.67" "20" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "Glutathione synthesis and recycling; Paracetamol ADME" "" "2" "0" "1.010" "1.010" "0.984" "0.998" "0.999" "0.939" "0.886" "0.934" "0.988" "5012.0" "5063.4" "5063.7" "4931.1" "5000.6" "5009.1" "4708.5" "4441.8" "4682.3" "4951.6" "" "" "" "" "" "" "" "" "" "" "4025.6" "3653.6" "4022.2" "3303.8" "3458.5" "3758.2" "3296.6" "3243.9" "4682.3" "4026.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-885056090803738498" "False" "High" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "0.000" "False" "200.894" "50" "33" "59" "32" "775" "87.7" "7.15" "210.36" "33" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558, Pf20974" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "" "3" "0" "1.015" "1.001" "1.004" "1.003" "0.991" "0.976" "0.995" "0.988" "1.004" "4088.2" "4149.8" "4092.9" "4104.4" "4100.7" "4049.5" "3989.5" "4068.5" "4040.2" "4103.4" "" "" "" "" "" "" "" "" "" "" "3283.6" "2994.4" "3251.1" "2750.0" "2836.1" "3038.3" "2793.2" "2971.2" "4040.2" "3337.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8610404900026586522" "False" "High" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "0.000" "False" "198.313" "53" "28" "85" "27" "417" "48.1" "4.44" "251.43" "28" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "13" "1" "0.836" "0.848" "0.833" "0.802" "0.863" "0.835" "0.774" "0.810" "0.841" "10208.9" "8536.3" "8652.6" "8502.5" "8189.7" "8805.3" "8527.5" "7904.3" "8270.1" "8588.3" "" "" "" "" "" "" "" "" "" "" "8199.7" "6159.6" "6873.0" "5696.7" "5664.0" "6606.4" "5970.5" "5772.6" "8270.1" "6984.3" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915222884888566270" "False" "High" "IsMasterProtein" "O15020" "Spectrin beta chain, non-erythrocytic 2 OS=Homo sapiens OX=9606 GN=SPTBN2 PE=1 SV=3" "0.000" "False" "197.780" "18" "35" "44" "32" "2390" "271.2" "6.11" "156.95" "35" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf15410" "6712" "ENSG00000173898" "SPTBN2" "hsa:6712; O14872; O14873; O15020" "MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins" "" "5" "2" "1.041" "0.981" "1.092" "1.056" "1.023" "1.066" "1.027" "1.044" "1.024" "3377.0" "3515.8" "3314.4" "3687.8" "3564.6" "3453.1" "3598.5" "3469.1" "3524.2" "3458.0" "" "" "" "" "" "" "" "" "" "" "2712.3" "2536.9" "2632.7" "2470.8" "2465.3" "2590.8" "2519.4" "2533.5" "3524.2" "2812.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-160533791377362281" "False" "High" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "0.000" "False" "196.569" "58" "18" "181" "16" "334" "36.6" "6.05" "585.91" "18" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Pyruvate metabolism" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "2" "0.981" "0.988" "0.940" "0.962" "0.985" "0.943" "0.953" "0.951" "0.962" "17428.8" "17090.8" "17212.0" "16379.5" "16768.9" "17166.9" "16439.8" "16616.0" "16583.0" "16774.0" "" "" "" "" "" "" "" "" "" "" "13998.6" "12332.2" "13672.0" "10974.3" "11597.5" "12880.0" "11510.3" "12134.7" "16583.0" "13641.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978266596079071295" "False" "High" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "0.000" "False" "195.977" "49" "22" "87" "12" "475" "51.9" "8.06" "282.01" "22" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "7" "11" "0.995" "1.019" "0.997" "0.960" "1.000" "0.974" "0.939" "0.961" "0.965" "8380.5" "8338.8" "8542.3" "8356.6" "8045.4" "8379.4" "8162.2" "7873.0" "8052.7" "8090.9" "" "" "" "" "" "" "" "" "" "" "6731.1" "6017.0" "6785.4" "5598.9" "5564.3" "6286.9" "5714.8" "5749.7" "8052.7" "6579.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5279545747934132258" "False" "High" "IsMasterProtein" "P04350" "Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2" "0.000" "False" "195.685" "60" "18" "190" "2" "444" "49.6" "4.88" "502.01" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10382" "ENSG00000104833" "TUBB4A" "B3KQP4; hsa:10382; P04350; Q969E5" "Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "41" "1" "0.943" "0.936" "1.276" "1.020" "1.206" "1.319" "1.263" "1.199" "1.214" "53.4" "50.3" "50.0" "68.1" "54.5" "64.4" "70.4" "67.4" "64.0" "64.8" "" "" "" "" "" "" "" "" "" "" "42.9" "36.3" "39.7" "45.6" "37.7" "48.3" "49.3" "49.3" "64.0" "52.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636491781207187808" "False" "High" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "0.000" "False" "195.673" "67" "31" "77" "31" "501" "57.1" "6.55" "242.07" "31" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Alanine and aspartate metabolism" "3" "0" "1.002" "1.041" "0.985" "0.992" "1.019" "0.957" "0.975" "1.038" "1.012" "7113.1" "7129.1" "7406.2" "7003.9" "7056.1" "7246.6" "6809.0" "6937.0" "7386.3" "7200.2" "" "" "" "" "" "" "" "" "" "" "5713.1" "5144.2" "5883.0" "4692.6" "4880.1" "5437.0" "4767.3" "5066.1" "7386.3" "5855.5" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2847148615950550488" "False" "High" "IsMasterProtein" "P20700" "Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2" "0.000" "False" "195.522" "48" "24" "45" "22" "586" "66.4" "5.16" "168.44" "24" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf00932" "4001" "ENSG00000113368" "LMNB1" "B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6" "RHOD GTPase cycle; RHOF GTPase cycle; Meiotic synapsis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "14" "2" "0.970" "0.923" "0.988" "1.027" "1.055" "0.988" "1.038" "1.059" "0.969" "4635.7" "4495.7" "4278.4" "4578.6" "4762.8" "4890.8" "4581.0" "4813.8" "4908.4" "4492.9" "" "" "" "" "" "" "" "" "" "" "3723.3" "3244.0" "3398.5" "3067.7" "3294.0" "3669.5" "3207.4" "3515.5" "4908.4" "3653.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8372900262212064526" "False" "High" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "0.000" "False" "195.355" "49" "17" "141" "13" "372" "38.7" "9.13" "427.12" "17" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "mRNA processing" "6" "1" "1.053" "1.025" "1.058" "1.127" "1.047" "1.067" "1.085" "1.098" "1.087" "6377.9" "6715.6" "6535.9" "6750.3" "7189.8" "6678.1" "6808.2" "6920.3" "7001.0" "6930.9" "" "" "" "" "" "" "" "" "" "" "5122.7" "4845.8" "5191.7" "4522.7" "4972.5" "5010.5" "4766.8" "5053.9" "7001.0" "5636.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785490494886001566" "False" "High" "IsMasterProtein" "A6NC98" "Coiled-coil domain-containing protein 88B OS=Homo sapiens OX=9606 GN=CCDC88B PE=1 SV=1" "0.000" "False" "194.232" "26" "36" "51" "36" "1476" "164.7" "5.11" "177.76" "36" "cell organization and biogenesis;stress response;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf19047" "283234" "ENSG00000168071" "CCDC88B" "A5D8Y5; A6NC98; B5MDM2; hsa:283234; Q05BL2; Q6RUV3; Q8N1Q6; Q8NF44; Q9H0H1" "" "" "0" "0" "1.084" "1.004" "1.042" "1.043" "0.999" "1.046" "1.069" "1.024" "1.047" "3734.4" "4049.4" "3747.6" "3891.4" "3894.9" "3730.7" "3907.3" "3993.1" "3822.8" "3908.4" "" "" "" "" "" "" "" "" "" "" "2999.5" "2921.9" "2976.8" "2607.3" "2693.8" "2799.1" "2735.7" "2916.1" "3822.8" "3178.5" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "275596885495269995" "False" "High" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "0.000" "False" "194.203" "45" "21" "45" "21" "644" "74.4" "5.53" "185.92" "21" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "0.982" "0.998" "1.052" "1.110" "1.057" "1.090" "1.085" "1.047" "1.082" "2557.4" "2511.1" "2552.8" "2691.1" "2838.9" "2702.3" "2786.5" "2774.8" "2678.2" "2768.3" "" "" "" "" "" "" "" "" "" "" "2054.1" "1811.9" "2027.8" "1803.0" "1963.4" "2027.5" "1951.0" "2026.5" "2678.2" "2251.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-165801227635855458" "False" "High" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "0.000" "False" "193.763" "28" "20" "61" "20" "825" "90.5" "6.00" "222.17" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "4" "0" "0.986" "1.065" "1.000" "1.033" "1.007" "1.038" "1.039" "1.072" "1.039" "6274.1" "6184.6" "6684.1" "6276.8" "6479.6" "6319.8" "6514.7" "6518.7" "6725.8" "6518.8" "" "" "" "" "" "" "" "" "" "" "5039.3" "4462.6" "5309.4" "4205.5" "4481.3" "4741.6" "4561.3" "4760.6" "6725.8" "5301.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8112712839841425381" "False" "High" "IsMasterProtein" "Q8TAQ2" "SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1" "0.000" "False" "193.725" "29" "36" "60" "27" "1214" "132.8" "5.69" "205.16" "36" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6601" "ENSG00000139613" "SMARCC2" "F8VTJ5; hsa:6601; Q59GV3; Q8TAQ2; Q92923; Q96E12; Q96GY4" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "7" "5" "0.986" "1.013" "1.017" "0.991" "0.948" "1.017" "1.092" "1.063" "1.005" "4463.3" "4401.1" "4521.3" "4540.3" "4423.0" "4231.6" "4540.1" "4872.2" "4744.6" "4487.2" "" "" "" "" "" "" "" "" "" "" "3584.9" "3175.7" "3591.4" "3042.0" "3059.0" "3174.9" "3178.7" "3558.2" "4744.6" "3649.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770447616449315305" "False" "High" "IsMasterProtein" "Q9Y678" "Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1" "0.000" "False" "193.623" "34" "25" "49" "24" "874" "97.7" "5.47" "183.75" "25" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01602, Pf08752, Pf16381" "22820" "ENSG00000181789" "COPG1" "A8K6M8; B3KMF6; hsa:22820; Q54AC4; Q9Y678" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "VEGFA-VEGFR2 signaling" "3" "1" "1.001" "1.008" "0.991" "1.014" "0.983" "0.967" "0.995" "1.012" "0.997" "4496.3" "4502.5" "4532.4" "4455.4" "4559.8" "4418.0" "4349.8" "4474.8" "4548.0" "4483.4" "" "" "" "" "" "" "" "" "" "" "3611.3" "3248.9" "3600.3" "2985.1" "3153.6" "3314.8" "3045.5" "3268.0" "4548.0" "3646.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3283541064302857350" "False" "High" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "0.000" "False" "193.309" "33" "32" "55" "32" "1304" "145.7" "7.09" "180.43" "32" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; 10q11.21q11.23 copy number variation syndrome" "5" "0" "0.993" "1.024" "1.011" "1.006" "1.042" "0.987" "1.011" "1.020" "1.025" "3786.6" "3761.8" "3877.7" "3829.5" "3810.8" "3945.4" "3738.2" "3826.5" "3862.7" "3882.2" "" "" "" "" "" "" "" "" "" "" "3041.4" "2714.4" "3080.2" "2565.8" "2635.6" "2960.2" "2617.3" "2794.5" "3862.7" "3157.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3084200639085863850" "False" "High" "IsMasterProtein" "O14497" "AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3" "0.000" "False" "193.163" "21" "35" "52" "33" "2285" "241.9" "6.70" "182.15" "35" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "8289" "ENSG00000117713" "ARID1A" "D3DPL1; hsa:8289; O14497; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "7" "2" "1.005" "1.052" "1.047" "1.015" "1.025" "1.033" "1.073" "1.051" "1.031" "2909.6" "2923.5" "3061.7" "3047.0" "2953.0" "2982.1" "3005.0" "3121.4" "3057.5" "2999.3" "" "" "" "" "" "" "" "" "" "" "2337.0" "2109.5" "2432.0" "2041.5" "2042.3" "2237.4" "2103.9" "2279.5" "3057.5" "2439.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945585302651271031" "False" "High" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "0.000" "False" "192.918" "39" "29" "68" "29" "847" "94.6" "6.25" "220.82" "29" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "1.062" "1.093" "0.961" "1.040" "1.002" "0.922" "1.109" "1.033" "1.034" "4625.6" "4912.2" "5057.8" "4444.7" "4811.9" "4636.5" "4265.8" "5129.0" "4779.1" "4782.4" "" "" "" "" "" "" "" "" "" "" "3715.2" "3544.5" "4017.6" "2978.0" "3328.0" "3478.7" "2986.7" "3745.7" "4779.1" "3889.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6996937188134376608" "False" "High" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "0.000" "False" "192.674" "29" "33" "69" "33" "1140" "126.9" "5.26" "219.43" "33" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "14" "0" "0.998" "0.991" "1.004" "0.994" "0.978" "0.968" "0.993" "0.965" "0.977" "5940.7" "5931.6" "5889.5" "5961.7" "5907.9" "5808.4" "5751.4" "5896.3" "5732.4" "5801.2" "" "" "" "" "" "" "" "" "" "" "4771.5" "4280.1" "4678.2" "3994.3" "4086.0" "4357.9" "4026.8" "4306.1" "5732.4" "4717.8" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3650651295291502810" "False" "High" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "0.000" "False" "192.177" "17" "36" "42" "32" "2602" "278.0" "5.73" "151.92" "36" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "ISG15 antiviral mechanism" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome" "6" "0" "0.969" "0.986" "1.014" "0.992" "0.989" "1.121" "1.082" "1.069" "1.027" "3559.9" "3450.0" "3509.3" "3611.0" "3533.2" "3519.5" "3992.2" "3851.9" "3805.7" "3657.1" "" "" "" "" "" "" "" "" "" "" "2859.3" "2489.4" "2787.6" "2419.4" "2443.6" "2640.6" "2795.1" "2813.0" "3805.7" "2974.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5207555211981118816" "False" "High" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "0.000" "False" "192.118" "43" "25" "46" "25" "767" "86.4" "6.77" "156.85" "25" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.990" "0.982" "0.977" "0.967" "0.938" "0.929" "0.949" "0.935" "0.944" "4178.2" "4135.3" "4102.5" "4080.4" "4041.3" "3920.2" "3879.9" "3967.2" "3907.3" "3944.5" "" "" "" "" "" "" "" "" "" "" "3355.9" "2983.9" "3258.8" "2733.9" "2795.0" "2941.2" "2716.5" "2897.3" "3907.3" "3207.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2355880035621835112" "False" "High" "IsMasterProtein" "O15067" "Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4" "0.000" "False" "192.058" "29" "31" "53" "31" "1338" "144.6" "5.76" "194.80" "31" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02769, Pf13507, Pf18072, Pf18076" "5198" "ENSG00000178921" "PFAS" "A6H8V8; hsa:5198; O15067" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "0.953" "0.993" "0.990" "0.981" "0.962" "0.996" "0.937" "0.959" "0.951" "3813.4" "3635.7" "3788.0" "3775.9" "3741.5" "3667.0" "3798.6" "3571.4" "3657.0" "3624.8" "" "" "" "" "" "" "" "" "" "" "3062.9" "2623.4" "3008.9" "2529.8" "2587.7" "2751.3" "2659.6" "2608.2" "3657.0" "2947.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4874670657009698466" "False" "High" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "0.000" "False" "191.931" "22" "47" "64" "47" "2335" "273.4" "8.84" "195.49" "47" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.002" "1.082" "1.014" "0.961" "1.017" "0.952" "1.011" "0.997" "1.021" "4906.8" "4917.2" "5307.5" "4976.5" "4713.1" "4992.6" "4672.2" "4959.1" "4890.5" "5010.2" "" "" "" "" "" "" "" "" "" "" "3941.1" "3548.1" "4215.9" "3334.3" "3259.6" "3745.9" "3271.2" "3621.7" "4890.5" "4074.5" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1047543099056468626" "False" "High" "IsMasterProtein" "P09104" "Gamma-enolase OS=Homo sapiens OX=9606 GN=ENO2 PE=1 SV=3" "0.000" "False" "191.724" "57" "17" "100" "13" "434" "47.2" "5.03" "357.09" "17" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "2026" "ENSG00000111674" "ENO2" "B7Z2X9; hsa:2026; P09104; Q96J33" "Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "1" "1.024" "1.002" "1.025" "0.996" "0.975" "0.981" "0.948" "0.983" "0.991" "1461.0" "1495.8" "1464.4" "1497.6" "1455.2" "1424.5" "1433.7" "1384.6" "1436.0" "1448.3" "" "" "" "" "" "" "" "" "" "" "1173.5" "1079.4" "1163.3" "1003.4" "1006.4" "1068.7" "1003.8" "1011.2" "1436.0" "1177.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653265809957974706" "False" "High" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "0.000" "False" "191.700" "26" "20" "39" "19" "1087" "114.5" "7.11" "164.60" "20" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.016" "1.049" "1.047" "1.050" "1.072" "1.026" "1.100" "1.068" "1.067" "3382.4" "3436.8" "3547.6" "3543.0" "3551.3" "3625.3" "3471.2" "3721.9" "3612.5" "3607.8" "" "" "" "" "" "" "" "" "" "" "2716.7" "2479.9" "2817.9" "2373.8" "2456.1" "2720.0" "2430.4" "2718.1" "3612.5" "2934.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452221919959736930" "False" "High" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "0.000" "False" "191.310" "30" "30" "42" "27" "1294" "141.0" "8.40" "134.49" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348, Pf21040" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "7q11.23 copy number variation syndrome" "8" "2" "1.066" "1.077" "1.108" "1.117" "1.032" "1.030" "1.166" "1.115" "1.053" "3342.4" "3561.7" "3598.2" "3704.4" "3734.4" "3447.7" "3442.8" "3895.8" "3727.3" "3518.3" "" "" "" "" "" "" "" "" "" "" "2684.6" "2570.0" "2858.2" "2481.9" "2582.8" "2586.8" "2410.5" "2845.1" "3727.3" "2861.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6529775950404904251" "False" "High" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "0.000" "False" "190.423" "33" "26" "42" "26" "864" "94.2" "5.11" "155.12" "26" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "EGF/EGFR signaling pathway" "4" "0" "0.976" "0.952" "0.976" "1.002" "0.975" "0.985" "0.987" "1.010" "1.001" "3618.2" "3532.2" "3446.2" "3531.0" "3626.1" "3528.3" "3562.5" "3571.9" "3653.1" "3621.2" "" "" "" "" "" "" "" "" "" "" "2906.1" "2548.7" "2737.4" "2365.8" "2507.8" "2647.2" "2494.3" "2608.5" "3653.1" "2944.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1936662048644361405" "False" "High" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "0.000" "False" "190.150" "34" "31" "68" "31" "971" "110.3" "5.77" "213.66" "31" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "1.005" "0.986" "0.988" "0.988" "0.972" "0.921" "0.980" "0.959" "0.965" "6170.6" "6198.9" "6083.2" "6094.0" "6098.3" "6000.5" "5683.5" "6048.4" "5916.2" "5956.2" "" "" "" "" "" "" "" "" "" "" "4956.1" "4472.9" "4832.1" "4083.0" "4217.6" "4502.1" "3979.3" "4417.2" "5916.2" "4843.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4212925493234983848" "False" "High" "IsMasterProtein" "Q14289" "Protein-tyrosine kinase 2-beta OS=Homo sapiens OX=9606 GN=PTK2B PE=1 SV=2" "0.000" "False" "190.118" "42" "37" "64" "36" "1009" "115.8" "6.25" "205.57" "37" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "transporter activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "2185" "ENSG00000120899" "PTK2B" "D3DST0; hsa:2185; Q13475; Q14289; Q14290; Q16709; Q6PID4" "RHOU GTPase cycle; Interleukin-2 signaling; Signal regulatory protein family interactions; VEGFA-VEGFR2 Pathway" "IL-7 signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-2 signaling pathway; CCL18 signaling pathway; NPHP1 deletion syndrome; 8q11.23 (RB1CC1) copy number variation; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "21" "0" "1.046" "1.014" "1.001" "1.003" "0.995" "0.938" "1.017" "1.022" "0.998" "3632.3" "3800.4" "3682.0" "3636.7" "3643.3" "3615.4" "3407.2" "3693.0" "3712.1" "3625.8" "" "" "" "" "" "" "" "" "" "" "2917.4" "2742.2" "2924.7" "2436.6" "2519.7" "2712.6" "2385.5" "2697.0" "3712.1" "2948.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4765552648658305889" "False" "High" "IsMasterProtein" "Q96JH7" "Deubiquitinating protein VCPIP1 OS=Homo sapiens OX=9606 GN=VCPIP1 PE=1 SV=2" "0.000" "False" "189.703" "31" "31" "44" "31" "1222" "134.2" "7.20" "169.08" "31" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02338, Pf19437, Pf21403" "80124" "ENSG00000175073" "VCPIP1" "hsa:80124; Q504T4; Q86T93; Q86W01; Q8N3A9; Q96JH7; Q9H5R8" "Ovarian tumor domain proteases" "Alstrom syndrome" "2" "0" "1.010" "0.999" "1.006" "0.996" "0.989" "0.971" "0.997" "0.980" "0.979" "3868.0" "3904.9" "3864.4" "3892.0" "3852.9" "3826.4" "3754.1" "3857.1" "3792.5" "3787.0" "" "" "" "" "" "" "" "" "" "" "3106.8" "2817.6" "3069.6" "2607.6" "2664.7" "2870.9" "2628.4" "2816.9" "3792.5" "3079.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479686062085054609" "False" "High" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "0.000" "False" "189.599" "66" "16" "79" "11" "356" "37.5" "7.09" "267.70" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "Ferroptosis" "3" "7" "1.010" "0.997" "1.021" "0.991" "0.947" "0.971" "1.008" "0.999" "0.999" "5667.5" "5726.3" "5651.2" "5786.0" "5613.9" "5367.3" "5504.8" "5715.1" "5659.1" "5659.3" "" "" "" "" "" "" "" "" "" "" "4552.1" "4131.9" "4489.0" "3876.6" "3882.6" "4027.0" "3854.1" "4173.8" "5659.1" "4602.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305624722430213023" "False" "High" "IsMasterProtein" "Q9H4A3" "Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2" "0.000" "False" "189.164" "14" "32" "53" "32" "2382" "250.6" "6.34" "180.54" "32" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf12202" "65125" "ENSG00000060237" "WNK1" "A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3; hsa:65125; O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; Q96CZ6; Q9H4A3; Q9P1S9" "Stimuli-sensing channels" "Ciliary landscape" "2" "0" "1.019" "1.003" "1.024" "1.013" "0.982" "1.011" "1.014" "1.015" "1.021" "4932.9" "5025.9" "4949.6" "5052.2" "4994.5" "4843.8" "4986.0" "5002.6" "5005.0" "5035.9" "" "" "" "" "" "" "" "" "" "" "3962.0" "3626.6" "3931.6" "3384.9" "3454.3" "3634.2" "3490.9" "3653.4" "5005.0" "4095.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260804329009372873" "False" "High" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "0.000" "False" "188.062" "28" "30" "46" "30" "1269" "144.7" "6.05" "160.42" "30" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00560, Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "" "VEGFA-VEGFR2 signaling; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "0.990" "1.004" "1.002" "1.023" "0.987" "0.990" "1.025" "1.002" "0.999" "4376.8" "4331.5" "4392.2" "4385.1" "4477.2" "4322.0" "4335.2" "4485.9" "4385.5" "4372.5" "" "" "" "" "" "" "" "" "" "" "3515.4" "3125.5" "3488.8" "2938.0" "3096.5" "3242.7" "3035.3" "3276.1" "4385.5" "3555.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1734790582977372175" "False" "High" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "0.000" "False" "187.490" "45" "28" "64" "28" "660" "75.3" "6.68" "227.98" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Amino acid metabolism" "3" "0" "1.007" "1.003" "0.969" "0.996" "0.980" "0.965" "0.997" "0.964" "0.994" "6858.4" "6909.3" "6882.2" "6645.2" "6831.4" "6722.6" "6620.4" "6840.7" "6613.4" "6817.1" "" "" "" "" "" "" "" "" "" "" "5508.6" "4985.6" "5466.8" "4452.3" "4724.6" "5043.8" "4635.3" "4995.8" "6613.4" "5543.9" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3988284594388072596" "False" "High" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "0.000" "False" "187.411" "39" "33" "50" "33" "986" "111.5" "7.27" "174.22" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "Pathogenic Escherichia coli infection" "5" "0" "1.050" "0.984" "1.057" "0.990" "0.903" "0.889" "1.027" "0.955" "0.961" "3698.9" "3885.1" "3638.5" "3908.3" "3661.1" "3338.6" "3288.4" "3799.3" "3530.9" "3555.6" "" "" "" "" "" "" "" "" "" "" "2970.9" "2803.4" "2890.2" "2618.5" "2532.1" "2504.9" "2302.4" "2774.6" "3530.9" "2891.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7738217365816998519" "False" "High" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "0.000" "False" "187.396" "42" "27" "62" "27" "739" "83.1" "7.03" "219.12" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "HDAC6 interactions in the central nervous system" "3" "0" "0.965" "0.999" "0.966" "0.975" "0.947" "0.988" "0.961" "0.957" "0.947" "5459.0" "5270.0" "5450.8" "5274.5" "5320.0" "5170.2" "5391.8" "5247.5" "5222.2" "5167.5" "" "" "" "" "" "" "" "" "" "" "4384.6" "3802.7" "4329.7" "3533.9" "3679.3" "3879.1" "3775.1" "3832.3" "5222.2" "4202.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8321804652329171157" "False" "High" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "0.000" "False" "187.343" "41" "37" "80" "31" "866" "101.2" "7.42" "247.61" "37" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "6" "0.978" "1.011" "0.959" "0.944" "0.976" "0.944" "0.919" "0.939" "0.954" "10204.4" "9979.9" "10321.6" "9787.1" "9630.1" "9961.2" "9637.5" "9378.1" "9581.8" "9733.5" "" "" "" "" "" "" "" "" "" "" "8196.1" "7201.2" "8198.8" "6557.3" "6660.2" "7473.7" "6747.7" "6848.8" "9581.8" "7915.6" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8288854614025876019" "False" "High" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "0.000" "False" "187.306" "74" "19" "161" "16" "255" "29.2" "4.74" "442.12" "19" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; RAB GEFs exchange GTP for GDP on RABs; Regulation of HSF1-mediated heat shock response; Signaling by Hippo; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; HSF1 activation; NADE modulates death signalling" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "26" "4" "0.997" "1.032" "0.977" "0.994" "1.031" "0.989" "0.971" "1.031" "0.995" "10155.6" "10123.2" "10481.9" "9920.2" "10093.3" "10468.2" "10042.3" "9859.1" "10472.2" "10101.8" "" "" "" "" "" "" "" "" "" "" "8156.9" "7304.6" "8326.1" "6646.6" "6980.6" "7854.1" "7031.1" "7200.1" "10472.2" "8215.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6789229082663828317" "False" "High" "IsMasterProtein" "Q6ZUJ8" "Phosphoinositide 3-kinase adapter protein 1 OS=Homo sapiens OX=9606 GN=PIK3AP1 PE=1 SV=2" "0.000" "False" "186.981" "39" "24" "43" "24" "805" "90.3" "5.40" "151.27" "24" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "118788" "ENSG00000155629" "PIK3AP1" "hsa:118788; Q5TB56; Q5VXJ9; Q6ZUJ8; Q8N6J6; Q8NAC8" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "B cell receptor signaling pathway; PI3K-Akt signaling pathway" "6" "0" "1.010" "1.017" "1.003" "1.003" "0.961" "0.929" "1.038" "1.005" "1.007" "3824.7" "3862.6" "3889.6" "3838.0" "3835.5" "3674.5" "3551.7" "3970.2" "3845.3" "3852.8" "" "" "" "" "" "" "" "" "" "" "3071.9" "2787.2" "3089.7" "2571.5" "2652.7" "2756.9" "2486.7" "2899.4" "3845.3" "3133.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3391234540397172253" "False" "High" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "0.000" "False" "186.910" "29" "26" "46" "25" "1008" "114.7" "7.68" "162.67" "26" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "VEGFA-VEGFR2 signaling" "2" "0" "0.943" "0.949" "0.928" "0.932" "0.929" "0.964" "0.939" "0.941" "0.972" "3249.0" "3065.2" "3082.2" "3013.8" "3026.7" "3019.2" "3132.8" "3051.5" "3057.3" "3159.2" "" "" "" "" "" "" "" "" "" "" "2609.6" "2211.8" "2448.3" "2019.2" "2093.3" "2265.2" "2193.4" "2228.5" "3057.3" "2569.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-915816600694735360" "False" "High" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "0.000" "False" "186.782" "29" "27" "61" "27" "1071" "123.3" "6.06" "212.96" "27" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition; Maturation of hRSV A proteins" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "19" "0" "0.999" "1.033" "0.996" "0.979" "0.972" "0.932" "0.973" "0.961" "0.993" "7406.5" "7402.3" "7652.1" "7376.7" "7253.6" "7201.9" "6902.8" "7210.0" "7120.6" "7352.9" "" "" "" "" "" "" "" "" "" "" "5948.8" "5341.3" "6078.3" "4942.4" "5016.7" "5403.4" "4832.9" "5265.5" "7120.6" "5979.6" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6978617919950458725" "False" "High" "IsMasterProtein" "O43592" "Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2" "0.000" "False" "186.363" "32" "26" "61" "26" "962" "109.9" "5.39" "214.01" "26" "transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19282" "11260" "ENSG00000184575" "XPOT" "A6NLH1; hsa:11260; O43592; O43784; Q8WUG2; Q9BVS7" "tRNA processing in the nucleus" "" "1" "0" "0.995" "1.028" "0.999" "1.002" "1.002" "0.945" "0.964" "0.925" "1.007" "4670.1" "4645.5" "4802.0" "4666.6" "4680.2" "4679.5" "4414.2" "4500.6" "4320.0" "4704.5" "" "" "" "" "" "" "" "" "" "" "3751.0" "3352.1" "3814.4" "3126.6" "3236.9" "3510.9" "3090.6" "3286.8" "4320.0" "3825.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6176732133664384368" "False" "High" "IsMasterProtein" "Q70CQ2" "Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens OX=9606 GN=USP34 PE=1 SV=2" "0.000" "False" "186.284" "13" "39" "49" "39" "3546" "404.0" "5.82" "159.25" "39" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf12030" "9736" "ENSG00000115464" "USP34" "A8MWD0; B3KWU9; hsa:9736; O60316; O94834; Q3B777; Q6P6C9; Q70CQ2; Q7L8P6; Q8N3T9; Q8TBW2; Q9UGA1" "Ub-specific processing proteases; TCF dependent signaling in response to WNT" "" "2" "0" "1.016" "0.996" "1.021" "1.006" "0.948" "0.916" "1.015" "0.984" "1.002" "2967.4" "3014.0" "2954.7" "3028.6" "2984.5" "2812.4" "2718.4" "3012.3" "2920.2" "2974.3" "" "" "" "" "" "" "" "" "" "" "2383.4" "2174.8" "2347.0" "2029.2" "2064.1" "2110.1" "1903.3" "2199.9" "2920.2" "2418.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7082716862048425116" "False" "High" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "0.000" "False" "186.165" "29" "25" "45" "24" "1015" "114.3" "5.59" "164.94" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "Condensation of Prometaphase Chromosomes" "" "1" "0" "1.014" "1.018" "0.991" "0.986" "0.988" "0.917" "0.955" "0.959" "0.989" "3859.4" "3913.0" "3929.2" "3824.2" "3805.5" "3811.5" "3539.4" "3685.0" "3700.3" "3815.7" "" "" "" "" "" "" "" "" "" "" "3099.8" "2823.5" "3121.1" "2562.2" "2631.9" "2859.7" "2478.1" "2691.1" "3700.3" "3103.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5903683586191117105" "False" "High" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "0.000" "False" "185.469" "36" "29" "62" "29" "908" "100.1" "5.20" "214.08" "29" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "65" "0" "0.974" "0.984" "0.958" "0.935" "0.971" "0.964" "0.997" "0.962" "0.970" "6433.3" "6268.6" "6333.3" "6160.7" "6017.4" "6244.7" "6200.0" "6416.8" "6187.0" "6243.0" "" "" "" "" "" "" "" "" "" "" "5167.2" "4523.3" "5030.7" "4127.7" "4161.7" "4685.3" "4340.9" "4686.2" "6187.0" "5077.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5285928462194255524" "False" "High" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "0.000" "False" "185.054" "35" "20" "40" "20" "665" "75.7" "6.84" "153.61" "20" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "1.027" "1.039" "0.994" "0.987" "0.980" "1.008" "1.065" "1.059" "1.022" "4210.7" "4326.3" "4376.6" "4184.5" "4156.1" "4126.9" "4246.0" "4483.2" "4459.2" "4302.1" "" "" "" "" "" "" "" "" "" "" "3382.0" "3121.7" "3476.5" "2803.6" "2874.4" "3096.3" "2972.8" "3274.1" "4459.2" "3498.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1968544072233028588" "False" "High" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "0.000" "False" "185.011" "36" "25" "117" "24" "707" "76.1" "9.44" "329.55" "25" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "mRNA processing; Type 2 papillary renal cell carcinoma" "4" "1" "1.039" "1.033" "1.010" "1.068" "1.027" "1.012" "1.070" "1.079" "1.025" "6967.0" "7238.2" "7196.0" "7033.8" "7438.1" "7152.9" "7050.9" "7454.4" "7514.5" "7138.4" "" "" "" "" "" "" "" "" "" "" "5595.8" "5222.9" "5716.0" "4712.6" "5144.3" "5366.7" "4936.7" "5444.0" "7514.5" "5805.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629412907813045008" "False" "High" "IsMasterProtein" "Q14997" "Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2" "0.000" "False" "184.981" "20" "30" "42" "30" "1843" "211.2" "6.90" "151.90" "30" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11919, Pf16507" "23198" "ENSG00000068878" "PSME4" "hsa:23198; Q14997; Q1XBG4; Q1XBG5; Q1XBG6; Q2M1Z0; Q6IPR2; Q86XF8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "" "52" "0" "0.961" "0.995" "0.990" "1.005" "0.991" "0.973" "0.990" "0.997" "1.014" "3254.5" "3127.9" "3239.6" "3223.4" "3270.0" "3226.1" "3165.2" "3221.0" "3245.0" "3299.2" "" "" "" "" "" "" "" "" "" "" "2614.0" "2257.0" "2573.4" "2159.7" "2261.6" "2420.5" "2216.1" "2352.3" "3245.0" "2683.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2123612860387903516" "False" "High" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "0.000" "False" "184.699" "53" "25" "78" "25" "561" "64.3" "6.86" "243.51" "25" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "6" "0" "0.995" "1.021" "0.990" "0.988" "1.002" "0.956" "0.948" "1.008" "0.979" "7348.6" "7313.9" "7501.9" "7278.6" "7263.3" "7365.4" "7028.3" "6965.4" "7409.3" "7195.8" "" "" "" "" "" "" "" "" "" "" "5902.3" "5277.5" "5959.0" "4876.6" "5023.3" "5526.1" "4920.8" "5086.9" "7409.3" "5851.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001879318500673012" "False" "High" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "0.000" "False" "184.667" "37" "22" "94" "16" "636" "70.6" "9.50" "267.84" "22" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "13" "6" "0.980" "1.003" "0.998" "1.012" "0.945" "1.011" "0.982" "0.939" "0.973" "6426.5" "6299.9" "6442.8" "6416.3" "6506.3" "6070.5" "6494.4" "6310.5" "6034.9" "6255.9" "" "" "" "" "" "" "" "" "" "" "5161.7" "4545.8" "5117.7" "4298.9" "4499.8" "4554.6" "4547.1" "4608.6" "6034.9" "5087.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437948072660631583" "False" "High" "IsMasterProtein" "O60664" "Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3" "0.000" "False" "184.002" "52" "18" "53" "18" "434" "47.0" "5.44" "200.45" "18" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf03036" "10226" "ENSG00000105355" "PLIN3" "A8K4Y9; hsa:10226; K7EQF4; O60664; Q53G77; Q9BS03; Q9UBD7; Q9UP92" "Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy" "" "6" "0" "0.998" "0.993" "0.981" "1.005" "1.003" "0.952" "0.936" "0.968" "0.986" "4514.1" "4505.8" "4484.0" "4429.8" "4537.0" "4527.7" "4295.7" "4227.2" "4368.5" "4450.6" "" "" "" "" "" "" "" "" "" "" "3625.7" "3251.2" "3561.8" "2968.0" "3137.8" "3397.0" "3007.7" "3087.1" "4368.5" "3619.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45443448741042807" "False" "High" "IsMasterProtein" "P24928" "DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2" "0.000" "False" "183.836" "23" "35" "51" "35" "1970" "217.0" "7.37" "163.84" "35" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001" "5430" "" "POLR2A" "A6NN93; B9EH88; hsa:5430; P24928; Q6NX41" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing" "44" "0" "0.976" "1.045" "0.974" "0.993" "1.013" "0.939" "1.043" "1.029" "1.000" "4218.9" "4118.1" "4406.9" "4110.7" "4190.6" "4272.7" "3959.5" "4399.9" "4340.2" "4219.9" "" "" "" "" "" "" "" "" "" "" "3388.5" "2971.5" "3500.5" "2754.2" "2898.2" "3205.8" "2772.2" "3213.3" "4340.2" "3431.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4866414538171077072" "False" "High" "IsMasterProtein" "P31146" "Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4" "0.000" "False" "183.670" "42" "25" "108" "24" "461" "51.0" "6.68" "364.32" "25" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf08954, Pf16300" "11151" "ENSG00000102879" "CORO1A" "B2RBL1; hsa:11151; P31146; Q2YD73" "Prevention of phagosomal-lysosomal fusion" "16p11.2 proximal deletion syndrome" "2" "1" "1.003" "1.000" "1.018" "1.022" "1.001" "1.008" "0.989" "0.957" "0.996" "8338.2" "8362.9" "8341.9" "8489.0" "8518.6" "8343.5" "8407.4" "8249.3" "7978.0" "8306.2" "" "" "" "" "" "" "" "" "" "" "6697.1" "6034.4" "6626.2" "5687.6" "5891.5" "6260.0" "5886.5" "6024.5" "7978.0" "6754.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4462152622631022902" "False" "High" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "0.000" "False" "182.615" "28" "32" "50" "23" "1105" "122.8" "5.76" "171.62" "32" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "1.020" "1.041" "1.036" "0.969" "0.969" "0.979" "1.062" "1.093" "1.013" "3592.7" "3665.6" "3740.0" "3721.9" "3480.1" "3481.7" "3518.8" "3816.0" "3926.2" "3638.0" "" "" "" "" "" "" "" "" "" "" "2885.6" "2645.0" "2970.8" "2493.7" "2406.9" "2612.3" "2463.7" "2786.9" "3926.2" "2958.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1941852327752543049" "False" "High" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "0.000" "False" "182.520" "33" "31" "50" "31" "1102" "128.2" "5.55" "176.00" "31" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Regulation of TP53 Degradation; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of PTEN localization" "Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates" "10" "0" "1.003" "1.000" "1.002" "1.006" "0.973" "0.955" "1.003" "0.988" "0.994" "4880.6" "4894.9" "4878.4" "4889.3" "4910.0" "4749.0" "4660.8" "4892.9" "4824.0" "4849.4" "" "" "" "" "" "" "" "" "" "" "3920.1" "3532.0" "3875.0" "3275.8" "3395.8" "3563.1" "3263.2" "3573.3" "4824.0" "3943.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-795610127174802190" "False" "High" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "0.000" "False" "182.481" "45" "32" "92" "23" "586" "69.4" "6.27" "261.12" "32" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Netrin-1 signaling" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "11" "2" "0.926" "0.948" "0.937" "1.002" "0.989" "1.029" "1.025" "0.998" "0.947" "4359.0" "4036.8" "4133.1" "4082.6" "4366.4" "4313.2" "4483.5" "4470.1" "4349.8" "4126.8" "" "" "" "" "" "" "" "" "" "" "3501.1" "2912.8" "3283.1" "2735.4" "3019.8" "3236.1" "3139.1" "3264.6" "4349.8" "3356.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573654140983497752" "False" "High" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "0.000" "False" "182.332" "72" "15" "77" "15" "261" "28.8" "4.69" "274.29" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; NF1 copy number variation syndrome ; Rubinstein-Taybi syndrome 1" "47" "0" "0.926" "0.961" "0.930" "0.952" "0.955" "1.023" "0.993" "0.990" "0.959" "5981.3" "5538.6" "5747.6" "5562.3" "5693.3" "5715.1" "6116.8" "5937.3" "5918.6" "5735.6" "" "" "" "" "" "" "" "" "" "" "4804.1" "3996.5" "4565.5" "3726.7" "3937.5" "4287.9" "4282.7" "4336.0" "5918.6" "4664.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4342326397945372791" "False" "High" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "0.000" "False" "181.695" "32" "27" "40" "24" "1001" "113.6" "6.29" "157.28" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "E3 ubiquitin ligases ubiquitinate target proteins" "ATM signaling in development and disease" "2" "0" "1.006" "0.979" "1.046" "1.027" "0.986" "1.019" "1.025" "1.040" "1.004" "2392.4" "2407.1" "2343.1" "2503.1" "2458.1" "2358.3" "2437.5" "2451.9" "2487.9" "2401.0" "" "" "" "" "" "" "" "" "" "" "1921.5" "1736.9" "1861.2" "1677.1" "1700.0" "1769.4" "1706.6" "1790.7" "2487.9" "1952.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283450593618715734" "False" "High" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "0.000" "False" "181.535" "57" "21" "55" "21" "450" "50.7" "7.06" "181.46" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "P41240; Q2M3N2; Q6FGZ6" "Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Signaling by BRAF and RAF1 fusions; Negative regulation of FLT3; GAB1 signalosome; Integrin signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; RHOH GTPase cycle; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "18" "0" "1.020" "1.013" "0.990" "0.998" "0.996" "0.937" "0.951" "0.972" "0.980" "4313.9" "4399.9" "4370.3" "4272.0" "4304.8" "4297.6" "4042.1" "4101.0" "4191.3" "4229.3" "" "" "" "" "" "" "" "" "" "" "3464.8" "3174.9" "3471.5" "2862.2" "2977.2" "3224.4" "2830.0" "2994.9" "4191.3" "3439.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3069559242831628546" "False" "High" "IsMasterProtein" "Q7Z460" "CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1" "0.000" "False" "180.979" "21" "27" "40" "24" "1538" "169.3" "9.03" "138.99" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21040" "23332" "ENSG00000074054" "CLASP1" "A2RU21; B7ZLX3; F5GWS0; hsa:23332; O75118; Q2KHQ9; Q5H9P0; Q7Z460; Q8N5B8; Q9BQT5" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Role of ABL in ROBO-SLIT signaling" "Microtubule cytoskeleton regulation; Splicing factor NOVA regulated synaptic proteins; 7q11.23 copy number variation syndrome" "17" "0" "1.050" "1.046" "1.061" "1.084" "1.041" "1.031" "1.158" "1.118" "1.098" "2325.9" "2441.4" "2433.0" "2468.1" "2522.4" "2421.8" "2397.3" "2693.1" "2601.4" "2553.5" "" "" "" "" "" "" "" "" "" "" "1868.1" "1761.6" "1932.6" "1653.6" "1744.5" "1817.0" "1678.5" "1966.8" "2601.4" "2076.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2495561624923528868" "False" "High" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=3" "0.000" "False" "180.976" "34" "29" "51" "14" "949" "104.5" "5.06" "182.04" "29" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "162" "ENSG00000100280" "AP1B1" "C9JRD1; F8WDL0; hsa:162; P78436; Q10567; Q20WL3; Q86X54" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "11" "0.989" "0.972" "0.970" "1.013" "1.001" "0.974" "0.994" "0.983" "0.980" "3931.8" "3888.7" "3822.0" "3813.6" "3984.8" "3936.6" "3830.6" "3908.7" "3865.8" "3851.2" "" "" "" "" "" "" "" "" "" "" "3158.0" "2806.0" "3035.9" "2555.1" "2755.9" "2953.6" "2682.0" "2854.5" "3865.8" "3132.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410325427073227732" "False" "High" "IsMasterProtein" "Cont_P68103" "Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1" "0.000" "True" "180.851" "54" "23" "199" "12" "462" "50.1" "9.01" "587.40" "23" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "100009189; 100137407; 100173928; 100415334; 100455760; 100583632; 100720380; 100860780; 100894850; 100978974; 101016039; 101102857; 101114018; 101120236; 101143481; 101427577; 101925273; 102283704; 102540473; 102729396; 102952660; 102986013; 103243896; 104657006; 104668174; 104669279; 104675330; 105064770; 105589208; 108529199; 108538073; 109248229; 109261840; 109563706; 1915; 282220; 403506; 493922; 494136; 574059; 716010" "ENSBGRG00000009070; ENSBIXG00000015018; ENSBIXG00005015547; ENSBMUG00000019814; ENSBTAG00000014534; ENSCABG00000013336; ENSCAFG00000002656; ENSCAFG00000054475; ENSCAFG00000056088; ENSCAFG00000057183; ENSCAFG00030004385; ENSCAFG00030013393; ENSCAFG00030013497; ENSCAFG00030026219; ENSCAFG00040018088; ENSCAFG00845012150; ENSCATG00000039727; ENSCCAG00000033087; ENSCHIG00000010087; ENSCJAG00000083200; ENSCPOG00000004067; ENSCSAG00000014041; ENSCWAG00000008166; ENSEASG00005004328; ENSEASG00005023174; ENSFCAG00000030977; ENSG00000156508; ENSGGOG00000025675; ENSLCNG00005010676; ENSMMUG00000004852; ENSNLEG00000035164; ENSOARG00000006149; ENSOARG00000007762; ENSOARG00000011616; ENSOCUG00000008481; ENSPANG00000006932; ENSPCTG00005022294; ENSPLOG00000016117; ENSPPAG00000038736; ENSPPYG00000016777; ENSPTEG00000025546; ENSPTIG00000007871; ENSPTRG00000018347; ENSRBIG00000028957; ENSRROG00000044652; ENSSSCG00005007871; ENSSSCG00015021824; ENSSSCG00035049336; ENSSSCG00060027448; ENSSSCG00065043427; ENSSSCG00070013256; ENSTGEG00000013204" "EEF1A; Eef1a1; EEF1A1; LOC102523342; LOC102540473; LOC105064770; LOC105879067; LOC111096123; LOC111152497; LOC112630422; LOC118356941; RABEFLA2" "A0A096NSJ4; A0A0D9RNJ1; A0A2I3HHP9; A0A2J8PVY3; A0A2J8RYS8; A0A2K5N7Z5; A0A2K5RPQ1; A0A2K6KG30; A0A2K6RQ54; A0A2R9BYN3; A0A2U3XB66; A0A2Y9F799; A0A2Y9HH84; A0A2Y9K0L0; A0A452E2H7; A0A485PKI5; A0A4W2G2H2; A0A4X1U102; A0A5N4BZH2; A0A663DJ63; A0A667H9L1; A0A6I9I937; A0A6J0YU90; A0A6J1ZA85; A0A6J3HMT0; A0A6P5CAS0; A0A6P6HZ37; A0A6P7EC07; A0A6P7EG13; A0A6P9FBB6; A0A811YU57; A0A8B7HCC5; A0A8B8RGI1; A0A8B9X6G1; A0A8C0H2M0; A0A8C0NJT4; A0A8C3W2U9; A0A8C4L5X9; A0A8C8XSK7; A0A8C9HVZ6; A0A8C9JCC1; A0A8D0I6I6; A0A8D2F6F8; A0A8D8FTM6; A0A8H2XW05; A0A8I3VX86; A0A8M1H472; A0A8U0UW05; A0A9L0JZA8; A0A9V1E3R7; A0A9W3GP67; A5PK01; A9X189; aju:106980206; B1MTF5; B7NZC3; biu:109563706; bom:102283704; bta:282220; C3PT41; caty:105589208; cfa:403506; cfr:102523342; chx:100860780; cjc:100415334; cjc:100894850; cpoc:100720380; csab:103243896; dnm:101427577; elk:111152497; F1RQG6; F2Z4P4; F6VFC8; F7AW94; fca:493922; G2HFA2; G3S518; ggo:101143481; H0V2B3; hsa:1915; L8I7U3; lww:102729396; mcc:716010; mcf:101925273; mmur:105879067; mpuf:101672541; nle:100583632; nsu:110583033; oas:101102857; oas:101114018; oas:101120236; ocu:100009189; P04719; P04720; P68103; P68104; P68105; panu:100137407; panu:101016039; pcad:102986013; pcoo:112862036; pon:100173928; pon:100455760; pps:100978974; ptg:102952660; ptr:494136; Q0PY11; Q2KJJ3; Q4R5K0; Q5NVF3; Q5R1X2; Q5R4R8; Q66RN5; Q6IPS9; Q6IQ15; rbb:108529199; rbb:108538073; rro:104657006; rro:104668174; rro:104669279; rro:104675330; ssc:574059; umr:103657393; vpc:102540473; W5PD15; zca:118356820; zca:118356941" "Neutrophil degranulation; Protein methylation; HSF1 activation; Eukaryotic Translation Elongation; Neutrophil degranulation; Protein methylation; Eukaryotic Translation Elongation; HSF1 activation; Neutrophil degranulation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; Peptide chain elongation; SARS-CoV-1 modulates host translation machinery" "Translation factors; EGFR1 signaling pathway; Fragile X syndrome; 2q37 copy number variation syndrome; EGFR1 signaling pathway" "20" "9" "0.984" "0.996" "0.940" "0.975" "0.990" "0.948" "0.982" "1.000" "0.981" "15463.0" "15219.8" "15404.4" "14532.3" "15080.9" "15301.3" "14663.7" "15182.8" "15466.8" "15170.5" "" "" "" "" "" "" "" "" "" "" "12419.7" "10982.2" "12236.2" "9736.6" "10430.1" "11480.3" "10266.8" "11088.1" "15466.8" "12337.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7305935062523076867" "False" "High" "IsMasterProtein" "Q9Y3Z3" "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2" "0.000" "False" "180.533" "44" "25" "49" "25" "626" "72.2" "7.14" "179.54" "25" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01966, Pf07647" "25939" "ENSG00000101347" "SAMHD1" "B4E2A5; E1P5V2; hsa:25939; Q5JXG8; Q8N491; Q9H004; Q9H005; Q9H3U9; Q9Y3Z3" "Interferon alpha/beta signaling; Nucleotide catabolism" "" "2" "0" "0.999" "1.003" "0.964" "0.963" "0.956" "0.913" "0.993" "0.978" "0.970" "4781.4" "4776.7" "4796.3" "4607.5" "4603.3" "4570.6" "4366.1" "4745.7" "4675.3" "4637.1" "" "" "" "" "" "" "" "" "" "" "3840.3" "3446.7" "3809.8" "3087.0" "3183.7" "3429.3" "3056.9" "3465.8" "4675.3" "3771.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-990721738298047914" "False" "High" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "0.000" "False" "179.540" "77" "13" "58" "13" "241" "26.9" "5.17" "239.50" "13" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.968" "0.987" "0.947" "0.993" "0.980" "0.975" "0.951" "0.891" "0.948" "5139.0" "4973.9" "5071.9" "4865.1" "5102.3" "5036.5" "5011.1" "4887.9" "4579.4" "4873.3" "" "" "" "" "" "" "" "" "" "" "4127.6" "3589.0" "4028.8" "3259.6" "3528.8" "3778.8" "3508.5" "3569.7" "4579.4" "3963.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129667850847229200" "False" "High" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "0.000" "False" "179.448" "47" "22" "63" "22" "483" "53.1" "7.23" "216.76" "22" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "7" "0" "0.958" "0.990" "0.980" "0.971" "0.958" "0.977" "0.988" "0.962" "0.967" "6894.6" "6607.9" "6827.7" "6756.9" "6692.7" "6602.4" "6732.9" "6809.7" "6632.6" "6664.1" "" "" "" "" "" "" "" "" "" "" "5537.7" "4768.1" "5423.5" "4527.1" "4628.7" "4953.7" "4714.0" "4973.1" "6632.6" "5419.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394918450034897638" "False" "High" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "0.000" "False" "179.278" "34" "25" "66" "25" "814" "92.4" "5.00" "227.98" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.967" "1.021" "1.003" "0.975" "1.005" "0.989" "0.952" "0.922" "0.981" "5110.6" "4940.1" "5219.6" "5128.4" "4981.3" "5137.3" "5054.9" "4866.3" "4712.9" "5012.8" "" "" "" "" "" "" "" "" "" "" "4104.8" "3564.7" "4146.1" "3436.0" "3445.1" "3854.4" "3539.2" "3553.9" "4712.9" "4076.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4660808662127601060" "False" "High" "IsMasterProtein" "Q9NR09" "Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=3" "0.000" "False" "179.062" "9" "37" "44" "37" "4857" "529.9" "6.05" "141.98" "37" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00179, Pf00653, Pf12356" "57448" "ENSG00000115760" "BIRC6" "hsa:57448; Q9NR09; Q9ULD1" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "" "2" "0" "1.021" "1.036" "1.042" "1.018" "1.015" "0.979" "0.997" "1.006" "1.033" "3546.6" "3622.6" "3675.3" "3696.2" "3610.9" "3600.1" "3473.5" "3536.4" "3568.6" "3662.0" "" "" "" "" "" "" "" "" "" "" "2848.6" "2614.0" "2919.4" "2476.4" "2497.3" "2701.1" "2432.0" "2582.6" "3568.6" "2978.0" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4900440247780228765" "False" "High" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "0.000" "False" "179.031" "43" "30" "55" "30" "776" "89.6" "8.00" "180.86" "30" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Iron uptake and transport; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1; Regulation of BACH1 activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Pleural mesothelioma; Notch signaling pathway" "41" "0" "0.964" "0.989" "0.950" "0.972" "0.966" "0.990" "0.976" "0.967" "0.953" "5074.5" "4893.3" "5017.8" "4820.4" "4931.9" "4902.2" "5023.6" "4954.6" "4905.1" "4836.9" "" "" "" "" "" "" "" "" "" "" "4075.8" "3530.8" "3985.8" "3229.7" "3411.0" "3678.1" "3517.2" "3618.3" "4905.1" "3933.6" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350486907516670884" "False" "High" "IsMasterProtein" "Q7Z5K2" "Wings apart-like protein homolog OS=Homo sapiens OX=9606 GN=WAPL PE=1 SV=1" "0.000" "False" "178.456" "32" "32" "40" "31" "1190" "132.9" "5.44" "141.32" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07814" "23063" "ENSG00000062650" "WAPL" "A7E2B5; hsa:23063; Q5VSK5; Q7Z5K2; Q8IX10; Q92549" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "1" "1.022" "1.004" "1.001" "0.965" "0.954" "0.941" "0.999" "0.985" "0.982" "3559.1" "3636.1" "3573.7" "3562.1" "3434.9" "3393.9" "3348.0" "3556.6" "3504.0" "3494.6" "" "" "" "" "" "" "" "" "" "" "2858.6" "2623.7" "2838.7" "2386.6" "2375.6" "2546.4" "2344.1" "2597.4" "3504.0" "2841.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657262686538344528" "False" "High" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "0.000" "False" "178.446" "32" "30" "45" "30" "1129" "125.9" "5.62" "144.58" "30" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894, Pf20946" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "" "Mesodermal commitment pathway" "1" "0" "1.023" "0.971" "1.027" "0.989" "0.960" "1.052" "1.055" "1.062" "1.020" "3319.1" "3394.9" "3224.3" "3410.2" "3281.0" "3185.3" "3492.4" "3503.2" "3523.5" "3384.3" "" "" "" "" "" "" "" "" "" "" "2665.9" "2449.7" "2561.1" "2284.8" "2269.2" "2389.9" "2445.2" "2558.4" "3523.5" "2752.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037069693652576559" "False" "High" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "0.000" "False" "178.216" "46" "16" "86" "6" "449" "49.2" "6.30" "298.67" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; P31943; Q6IBM4" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "6" "8" "1.048" "1.058" "1.069" "1.090" "1.057" "1.053" "1.059" "1.110" "1.055" "5215.4" "5465.7" "5516.7" "5577.8" "5684.1" "5513.4" "5489.9" "5523.3" "5787.7" "5504.3" "" "" "" "" "" "" "" "" "" "" "4188.9" "3943.9" "4382.1" "3737.1" "3931.2" "4136.6" "3843.8" "4033.7" "5787.7" "4476.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370453687865171634" "False" "High" "IsMasterProtein" "P39880" "Homeobox protein cut-like 1 OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=3" "0.000" "False" "178.171" "26" "33" "46" "33" "1505" "164.1" "5.90" "166.07" "33" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf02376" "1523" "ENSG00000257923" "CUX1" "B3KV79; J3KQV9; P39880; Q6NYH4; Q75LE5; Q75MT2; Q75MT3; Q86UJ7; Q9UEV5" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "2" "0" "1.011" "1.016" "1.026" "1.031" "0.995" "0.959" "0.970" "1.005" "1.001" "4382.2" "4432.0" "4451.6" "4494.7" "4519.2" "4358.4" "4200.8" "4249.2" "4403.2" "4385.4" "" "" "" "" "" "" "" "" "" "" "3519.8" "3198.0" "3536.0" "3011.4" "3125.5" "3270.0" "2941.2" "3103.2" "4403.2" "3566.3" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5165886701298417594" "False" "High" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "0.000" "False" "177.918" "28" "21" "63" "21" "793" "88.8" "5.22" "212.75" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.980" "1.041" "0.987" "0.990" "0.994" "1.011" "1.027" "1.034" "1.020" "6624.3" "6488.7" "6897.2" "6540.3" "6560.9" "6583.0" "6696.3" "6805.7" "6848.6" "6758.6" "" "" "" "" "" "" "" "" "" "" "5320.6" "4682.1" "5478.7" "4382.0" "4537.6" "4939.1" "4688.4" "4970.2" "6848.6" "5496.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785579833791404998" "False" "High" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "0.000" "False" "176.503" "59" "22" "60" "22" "439" "49.2" "5.24" "186.11" "22" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "0.991" "0.999" "1.008" "1.005" "0.994" "0.983" "0.968" "1.033" "0.988" "4369.6" "4328.5" "4366.3" "4402.6" "4391.3" "4342.4" "4296.3" "4230.4" "4515.8" "4317.5" "" "" "" "" "" "" "" "" "" "" "3509.6" "3123.3" "3468.3" "2949.7" "3037.1" "3258.0" "3008.1" "3089.5" "4515.8" "3511.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8840476301148053294" "False" "High" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "0.000" "False" "176.282" "28" "33" "56" "33" "1328" "149.2" "6.74" "183.31" "33" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "Fanconi Anemia Pathway; TP53 Regulates Transcription of DNA Repair Genes" "Gastric cancer network 2; DNA repair pathways, full network; 15q11q13 copy number variation" "5" "0" "1.040" "0.995" "1.037" "1.031" "0.982" "0.992" "1.031" "1.021" "1.019" "4171.4" "4337.1" "4150.2" "4327.2" "4298.7" "4098.3" "4137.4" "4300.1" "4257.2" "4252.5" "" "" "" "" "" "" "" "" "" "" "3350.5" "3129.5" "3296.7" "2899.2" "2973.0" "3074.9" "2896.8" "3140.4" "4257.2" "3458.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4113768837461094803" "False" "High" "IsMasterProtein" "A0AVT1" "Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1" "0.000" "False" "176.167" "30" "26" "45" "26" "1052" "117.9" "6.14" "171.58" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "55236" "ENSG00000033178" "UBA6" "A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "0.999" "0.995" "0.953" "0.994" "0.985" "0.988" "0.974" "0.936" "1.008" "4637.6" "4633.7" "4614.3" "4420.0" "4612.0" "4569.8" "4582.7" "4515.9" "4341.2" "4675.9" "" "" "" "" "" "" "" "" "" "" "3724.8" "3343.6" "3665.3" "2961.4" "3189.7" "3428.6" "3208.5" "3298.0" "4341.2" "3802.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7405227159340641842" "False" "High" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "0.000" "False" "176.114" "60" "22" "59" "22" "406" "45.6" "7.55" "211.28" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "65" "0" "0.970" "1.001" "0.982" "0.970" "0.937" "0.935" "0.966" "0.929" "0.941" "5520.1" "5353.2" "5524.8" "5419.5" "5353.4" "5170.3" "5159.5" "5334.6" "5130.1" "5194.8" "" "" "" "" "" "" "" "" "" "" "4433.7" "3862.7" "4388.5" "3631.1" "3702.5" "3879.2" "3612.4" "3895.9" "5130.1" "4224.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7722253779426460975" "False" "High" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "0.000" "False" "176.023" "40" "27" "48" "8" "662" "73.2" "7.18" "165.54" "27" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Neutrophil degranulation" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "3" "14" "0.937" "0.999" "1.104" "1.117" "1.136" "1.243" "1.132" "1.113" "1.073" "3363.7" "3151.6" "3360.5" "3714.6" "3757.3" "3820.2" "4181.9" "3807.5" "3743.5" "3610.7" "" "" "" "" "" "" "" "" "" "" "2701.7" "2274.1" "2669.3" "2488.8" "2598.6" "2866.2" "2927.9" "2780.6" "3743.5" "2936.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500586164942944818" "False" "High" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "0.000" "False" "175.835" "51" "13" "101" "13" "324" "35.9" "9.88" "311.50" "13" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; Noncanonical activation of NOTCH3" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "10" "0" "0.959" "0.971" "0.970" "0.993" "0.994" "1.079" "0.950" "1.003" "0.982" "5441.4" "5220.3" "5282.2" "5278.8" "5405.1" "5411.4" "5873.5" "5172.0" "5459.1" "5344.5" "" "" "" "" "" "" "" "" "" "" "4370.5" "3766.8" "4195.9" "3536.8" "3738.2" "4060.1" "4112.3" "3777.1" "5459.1" "4346.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4377208032786879179" "False" "High" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "0.000" "False" "175.246" "75" "18" "65" "17" "240" "26.8" "4.73" "232.84" "18" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "XBP1(S) activates chaperone genes" "IL-18 signaling pathway" "2" "0" "1.045" "1.001" "1.033" "1.009" "1.024" "1.024" "1.027" "0.980" "0.999" "6705.9" "7004.3" "6709.6" "6929.3" "6767.7" "6865.8" "6864.2" "6883.7" "6574.7" "6702.0" "" "" "" "" "" "" "" "" "" "" "5386.1" "5054.1" "5329.7" "4642.6" "4680.6" "5151.3" "4806.0" "5027.2" "6574.7" "5450.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249429330709182822" "False" "High" "IsMasterProtein" "Cont_P68138" "Actin, alpha skeletal muscle OS=Bos taurus OX=9913 GN=ACTA1 PE=1 SV=1" "0.000" "True" "175.232" "47" "19" "539" "3" "377" "42.0" "5.39" "1380.27" "19" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100065454; 100154254; 100172818; 100395910; 100426612; 100542212; 100566789; 100609865; 100661558; 100716933; 100926492; 100955023; 100987270; 101018268; 101107662; 101316902; 101345310; 101371004; 101561057; 101607063; 101822895; 101878061; 101942538; 101972057; 102017886; 102121165; 102446120; 102836098; 102922102; 102943964; 103051164; 103127961; 103195041; 103624093; 103744113; 103818506; 104131026; 104291844; 104300855; 104488844; 104860683; 104987264; 105499142; 105505494; 105722343; 105823179; 105871143; 106543751; 106843698; 108498591; 108537854; 109248958; 109372851; 109689807; 11459; 281592; 29437; 58" "ENSABRG00000018240; ENSACAG00000001104; ENSACCG00020004955; ENSACDG00005004064; ENSACOG00000015573; ENSAMEG00000005186; ENSANAG00000033052; ENSANIG00000015411; ENSAOWG00000018027; ENSAPLG00000004146; ENSAPLG00020002125; ENSBGRG00000020862; ENSBIXG00000012362; ENSBIXG00005025901; ENSBMSG00010014761; ENSBTAG00000046332; ENSCABG00000013181; ENSCAFG00000008253; ENSCAFG00020027254; ENSCAFG00030012637; ENSCANG00000033017; ENSCCAG00000035682; ENSCCNG00000030664; ENSCGRG00001016859; ENSCJAG00000011114; ENSCLAG00000003307; ENSCMMG00000014710; ENSCMUG00000000473; ENSCPBG00000006129; ENSCPGG00000000824; ENSCPIG00010005220; ENSCPOG00000032187; ENSCPVG00000014620; ENSCSRG00000013784; ENSCUSG00005000547; ENSCWAG00000013028; ENSDLEG00000008382; ENSDNVG00000014331; ENSEASG00005031337; ENSEGOG00005009171; ENSFCAG00000030433; ENSFDAG00000018383; ENSFTIG00000004572; ENSG00000143632; ENSGAGG00000007922; ENSGEVG00005016044; ENSJHYG00000007552; ENSJJAG00000019369; ENSLAFG00000006306; ENSLCNG00005015654; ENSLLTG00000003642; ENSMCSG00000014926; ENSMFAG00000002280; ENSMGAG00000012010; ENSMICG00000007460; ENSMMNG00015014953; ENSMMSG00000010015; ENSMMUG00000022086; ENSMNEG00000003684; ENSMSIG00000009031; ENSMUNG00000016766; ENSMUSG00000031972; ENSNGAG00000008844; ENSNVIG00000023437; ENSOANG00000012845; ENSOARG00000003044; ENSOGAG00000016005; ENSOSUG00000015814; ENSPANG00000005524; ENSPCEG00000011384; ENSPCLG00000000773; ENSPCOG00000022008; ENSPCTG00005016061; ENSPEMG00000019882; ENSPLOG00000020512; ENSPMRG00000005431; ENSPPAG00000033916; ENSPPYG00000000127; ENSPSIG00000002854; ENSPSNG00000011648; ENSPSTG00000017705; ENSPTRG00000002086; ENSRBIG00000037124; ENSRFEG00010013727; ENSRNOG00000017786; ENSRNOG00055021900; ENSRNOG00060017592; ENSRNOG00065018197; ENSSCAG00000003577; ENSSHAG00000014035; ENSSHBG00005006730; ENSSMRG00000022024; ENSSOCG00000011564; ENSSSCG00000010190; ENSSSCG00015047339; ENSSSCG00040044916; ENSSSCG00055024685; ENSSSCG00065076746; ENSSSUG00005003524; ENSSTOG00000024222; ENSSVLG00005008349; ENSTGEG00000010273; ENSTGUG00000010041; ENSUAMG00000015031; ENSUPAG00010000311; ENSVKKG00000017431; ENSVURG00010000907; ENSVURG00010001203" "Acta1; ACTA1; LOC101345310; LOC101878061; LOC103127961; LOC103661861; LOC111160482; LOC112807841" "A0A090BWQ4; A0A091DQ28; A0A091EBT4; A0A091GSF2; A0A091GVU0; A0A091JKH4; A0A093GLM6; A0A096N2Y2; A0A098M1X6; A0A0A0AU99; A0A1S3APV3; A0A1U7QEW4; A0A1W7RJM3; A0A218VBM4; A0A226MSL5; A0A250XZP0; A0A2I0UAK3; A0A2J8M6H1; A0A2J8R810; A0A2K5EBS2; A0A2K5IRF2; A0A2K5S578; A0A2K5TYP0; A0A2K6ANM2; A0A2K6G1G8; A0A2K6LSJ0; A0A2P4SXB1; A0A2R9AZU8; A0A2U3W9D6; A0A2U4BVD6; A0A2Y9E0P7; A0A2Y9HE43; A0A2Y9L6W7; A0A2Y9LGX2; A0A2Y9S7L7; A0A3L7I1B1; A0A3L8S8G5; A0A3M0KHK7; A0A3Q7NT51; A0A452H615; A0A452RJE1; A0A480QNI6; A0A4U1EEU3; A0A4W2GZT5; A0A4X2JWN6; A0A5J5MT96; A0A5N3VLN8; A0A663E501; A0A667HAA9; A0A669PGX8; A0A670I895; A0A671F3Z0; A0A672U2N2; A0A673SW94; A0A6B2F569; A0A6B2F5D9; A0A6D2XHK8; A0A6I9M0F0; A0A6I9XXG7; A0A6J0HG37; A0A6J0T852; A0A6J1U9U4; A0A6J1YDW3; A0A6J2GP26; A0A6J2NA43; A0A6J3CTV5; A0A6J3EY96; A0A6P3ERW2; A0A6P3FJ88; A0A6P3HAS4; A0A6P5LDM6; A0A6P9CIM0; A0A6P9EZA5; A0A7J7EZ09; A0A7J7RJI6; A0A7J7RTV4; A0A7J8B841; A0A7J8BL15; A0A7K4JPE4; A0A7K4PSI7; A0A7K4QY10; A0A7K4RLR4; A0A7K4UDE9; A0A7K4UY42; A0A7K4W696; A0A7K4XA22; A0A7K4Y8W8; A0A7K4ZFF1; A0A7K5BDX3; A0A7K5D428; A0A7K5GNW3; A0A7K5HRK1; A0A7K5IK78; A0A7K5JXK4; A0A7K5KX43; A0A7K5MSI7; A0A7K5NP28; A0A7K5PKH5; A0A7K5QIU3; A0A7K5S142; A0A7K5SPK9; A0A7K5UC76; A0A7K5W8H5; A0A7K5XD37; A0A7K5Y7M0; A0A7K5ZW11; A0A7K6B2F8; A0A7K6BQV7; A0A7K6DCL1; A0A7K6EXZ1; A0A7K6FLR8; A0A7K6GNU4; A0A7K6HR31; A0A7K6J4T9; A0A7K6K4L6; A0A7K6LWQ9; A0A7K6M0L3; A0A7K6P948; A0A7K6RCV4; A0A7K6TEI2; A0A7K6VY88; A0A7K6XPH0; A0A7K6Z9M8; A0A7K6ZR93; A0A7K7AYM3; A0A7K7C659; A0A7K7DZL3; A0A7K7EWS4; A0A7K7G760; A0A7K7IH73; A0A7K7KDI8; A0A7K7KKJ6; A0A7K7MNF7; A0A7K7NEW8; A0A7K7PM04; A0A7K7QH90; A0A7K7RDG5; A0A7K7TAJ1; A0A7K7U609; A0A7K7XKX1; A0A7K8AQB9; A0A7K8BQL5; A0A7K8CRX7; A0A7K8EFR7; A0A7K8FRF9; A0A7K8GQ26; A0A7K8HWN9; A0A7K8ISA9; A0A7K8JPZ4; A0A7K8KS65; A0A7K8M0C5; A0A7K8N2Y9; A0A7K8PDY4; A0A7K8QME0; A0A7K8S6K4; A0A7K8T8U7; A0A7K8U5E0; A0A7K8VJC8; A0A7K8WMV3; A0A7K8Y2D4; A0A7K8YWW6; A0A7K8ZV32; A0A7K9AJ30; A0A7K9BS34; A0A7K9D6V1; A0A7K9EI05; A0A7K9FLR9; A0A7K9I701; A0A7K9IMC9; A0A7K9KC93; A0A7K9MVB8; A0A7K9NB46; A0A7K9PEG9; A0A7K9RST5; A0A7K9TK91; A0A7K9V843; A0A7K9W2K2; A0A7K9WX62; A0A7L0AFU5; A0A7L0BDS5; A0A7L0CIB3; A0A7L0EPL5; A0A7L0FCD1; A0A7L0G7Q5; A0A7L0HND8; A0A7L0II88; A0A7L0KT22; A0A7L0LSN2; A0A7L0NLS0; A0A7L0P7X4; A0A7L0RUG0; A0A7L0SJQ9; A0A7L0UGT7; A0A7L0XTP2; A0A7L0ZS39; A0A7L1B939; A0A7L1BT59; A0A7L1DMI6; A0A7L1DWR3; A0A7L1F253; A0A7L1GIR7; A0A7L1HPS8; A0A7L1IC62; A0A7L1K5Y1; A0A7L1L5V3; A0A7L1M7T5; A0A7L1NKU4; A0A7L1R8Z0; A0A7L1T000; A0A7L1U068; A0A7L1XCH6; A0A7L1YLD6; A0A7L2B7P4; A0A7L2BR48; A0A7L2CKL5; A0A7L2ESG9; A0A7L2FHP9; A0A7L2FY76; A0A7L2HHD4; A0A7L2IA74; A0A7L2JHG8; A0A7L2KMU3; A0A7L2LNS8; A0A7L2P8R5; A0A7L2QEC4; A0A7L2RU84; A0A7L2TB66; A0A7L2UV13; A0A7L2XQZ8; A0A7L2Z1X6; A0A7L2ZLP6; A0A7L3CN30; A0A7L3D9C1; A0A7L3GMY1; A0A7L3GYG9; A0A7L3ID24; A0A7L3IXN1; A0A7L3KUM5; A0A7L3LJJ7; A0A7L3M3X9; A0A7L3PPQ0; A0A7L3QHZ1; A0A7L3RH67; A0A7L3SGI7; A0A7L3U4P6; A0A7L3VNT2; A0A7L3WD55; A0A7L3Y1G6; A0A7L3YVD7; A0A7L3ZS54; A0A7L4AN29; A0A7L4CQM9; A0A7L4D5C7; A0A7L4DZI8; A0A7L4G527; A0A7L4GV55; A0A7L4IYY1; A0A7L4JN17; A0A7L4KJ61; A0A7L4MPA2; A0A7L4NEP2; A0A835NXC8; A0A850U7W3; A0A850V3D3; A0A850XEM6; A0A850Y843; A0A850ZDL2; A0A851BEY3; A0A851CN67; A0A851DTB7; A0A851EK28; A0A851FDE8; A0A851J837; A0A851KA41; A0A851LW39; A0A851NRY4; A0A851QJ25; A0A851RNA5; A0A851U848; A0A851VUC7; A0A851WKT2; A0A851XT74; A0A851YL06; A0A851ZBL2; A0A852BHA9; A0A852CRR6; A0A852D425; A0A852E1V9; A0A852F792; A0A852GJG7; A0A852IBF3; A0A852JDC5; A0A852JR42; A0A852KVX0; A0A852LXY4; A0A852NS61; A0A8B6ZNK4; A0A8B7GBR5; A0A8B7Q300; A0A8B8TZT0; A0A8B9CLG9; A0A8B9DEA1; A0A8B9GFW6; A0A8B9NJE6; A0A8B9QKT1; A0A8B9SHJ3; A0A8B9Y7Y7; A0A8C0DED2; A0A8C0H293; A0A8C0LYE1; A0A8C0N2I3; A0A8C2UWB6; A0A8C3CSU8; A0A8C3FFU4; A0A8C3L8M1; A0A8C3PH13; A0A8C3QCR3; A0A8C3SQW8; A0A8C3TNI9; A0A8C3WY11; A0A8C4PR70; A0A8C4U1I2; A0A8C4YAW6; A0A8C5IXG8; A0A8C5P2E0; A0A8C5RKR8; A0A8C5UFH7; A0A8C6FKL7; A0A8C6GS76; A0A8C6NGV1; A0A8C6QM24; A0A8C7BWL1; A0A8C8BUD5; A0A8C8S3P8; A0A8C8Y8T7; A0A8C9C427; A0A8C9LFS5; A0A8C9MJH4; A0A8D0E9T9; A0A8D0FGF9; A0A8D2B3M6; A0A8D2F0S7; A0A8D2GFE7; A0A8D2LUT0; A0A8J4MUQ6; A0A8J4N2X1; A0A8J4NK31; A0A8J4NVY9; A0A8J4PAG4; A0A8K0BNH4; A0A8K1LSE9; A0A8M1FCK6; A0A8P0NAG9; A0A8S9F5P5; A0A8U0V7M2; A0A9B0WSP0; A0A9F2KUS3; A0A9Q0Y593; A0A9V1E5M8; A0AA35K559; A0AA40L2Y5; A0AA41N2J4; acs:100566789; aful:116488210; aju:106984378; bbis:104987264; brhi:104488844; bta:281592; cang:105505494; cbrc:103624093; ccan:109689807; cfr:102507445; cjc:100395910; cmy:102943964; cpic:101942538; cpoc:100716933; cuca:104060336; cvf:104291844; dle:111163953; dpub:104300855; ecb:100065454; egz:104131026; elk:111160482; F7E1F2; F7FWZ0; F7HNV4; G1K932; G1LEZ5; G1NHJ8; G3SXX7; G3WM41; gga:421534; H0UXP6; H0XEG0; H0ZIF5; H2Q1A9; hai:109372851; hsa:58; I3N266; J3SBR4; K7F4I9; lav:100661558; M3XC93; M7AKZ6; maua:101822895; mcc:100426612; mcf:102121165; mgp:100542212; mmu:11459; mmur:105871143; mni:105499142; ngi:103744113; nss:113413315; nsu:110582311; oas:101107662; oga:100955023; oro:101371004; P02568; P68133; P68134; P68135; P68136; P68137; P68138; P68139; P99020; panu:101018268; pbi:103051164; pcad:102976743; pcoq:105823179; pcw:110217891; pdic:114512380; pgut:117672003; pon:100172818; pps:100987270; pss:102446120; ptr:100609865; pvt:110075363; Q3ZCG3; Q5R9Q5; Q5T8M9; rbb:108537854; rno:29437; scan:103818506; shr:100926492; ssc:100154254; T1E7F6; tmu:101345310; tsr:106543751; U3EUL6; U3I8T6; umr:103661861; V8NV61; W5NYJ1; zca:113923883" "Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction" "FAS pathway and stress induction of HSP regulation; Hypothetical network for drug addiction; Myometrial relaxation and contraction pathways; Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Striated muscle contraction; Myometrial relaxation and contraction pathways; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Burn wound healing; Pleural mesothelioma; Comprehensive IL-17A signaling; Striated muscle contraction" "22" "0" "1.068" "1.180" "1.043" "0.988" "1.147" "0.978" "0.928" "1.030" "1.050" "2370.6" "2531.5" "2798.3" "2471.7" "2342.7" "2718.8" "2317.5" "2199.6" "2442.3" "2488.9" "" "" "" "" "" "" "" "" "" "" "1904.0" "1826.6" "2222.8" "1656.0" "1620.2" "2039.9" "1622.6" "1606.4" "2442.3" "2024.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857660237806613264" "False" "High" "IsMasterProtein" "Q9NXV6" "CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3" "0.000" "False" "175.165" "52" "22" "33" "22" "580" "61.1" "9.01" "117.29" "22" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11952" "55602" "ENSG00000168564" "CDKN2AIP" "hsa:55602; Q8TBM5; Q9NXV6; Q9NYH0" "" "" "0" "0" "0.998" "0.985" "0.986" "0.958" "0.979" "0.946" "0.994" "1.025" "0.984" "3285.0" "3278.6" "3234.6" "3240.7" "3146.7" "3214.6" "3107.8" "3266.3" "3365.7" "3231.0" "" "" "" "" "" "" "" "" "" "" "2638.5" "2365.7" "2569.4" "2171.3" "2176.3" "2411.8" "2175.9" "2385.4" "3365.7" "2627.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796563562417500540" "False" "High" "IsMasterProtein" "P51532" "Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2" "0.000" "False" "174.754" "17" "26" "56" "19" "1647" "184.5" "7.88" "194.58" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6597" "ENSG00000127616" "SMARCA4" "B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; hsa:6597; O95052; P51532; Q9HBD3" "Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Interleukin-7 signaling; RMTs methylate histone arginines; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "Androgen receptor network in prostate cancer; Pre-implantation embryo; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Tumor suppressor activity of SMARCB1; Rett syndrome; Thermogenesis; Kleefstra syndrome" "13" "6" "1.019" "1.024" "1.037" "0.969" "0.971" "0.929" "1.002" "1.014" "0.999" "5069.7" "5166.8" "5190.2" "5257.2" "4911.4" "4922.7" "4710.1" "5079.9" "5142.2" "5062.1" "" "" "" "" "" "" "" "" "" "" "4071.9" "3728.2" "4122.7" "3522.4" "3396.8" "3693.4" "3297.8" "3709.9" "5142.2" "4116.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1146438711958021826" "False" "High" "IsMasterProtein" "Q16851" "UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5" "0.000" "False" "174.721" "54" "24" "52" "24" "508" "56.9" "8.15" "182.92" "24" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf01704" "7360" "ENSG00000169764" "UGP2" "hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15" "Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate" "Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation" "5" "0" "0.991" "0.988" "0.970" "0.981" "0.978" "0.994" "0.961" "0.949" "0.955" "4884.3" "4839.7" "4824.3" "4738.9" "4791.4" "4777.9" "4857.1" "4691.7" "4636.3" "4665.1" "" "" "" "" "" "" "" "" "" "" "3923.0" "3492.2" "3832.1" "3175.1" "3313.8" "3584.8" "3400.7" "3426.4" "4636.3" "3793.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866201622056559647" "False" "High" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "0.000" "False" "174.112" "33" "27" "68" "27" "835" "88.5" "5.77" "228.97" "27" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "HCMV Early Events; SUMOylation of transcription cofactors; Generic Transcription Pathway" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "6" "0" "0.984" "0.973" "0.976" "0.980" "0.974" "0.988" "0.987" "1.020" "1.010" "5482.4" "5397.2" "5335.7" "5349.5" "5373.9" "5337.3" "5416.4" "5408.6" "5590.1" "5535.6" "" "" "" "" "" "" "" "" "" "" "4403.4" "3894.5" "4238.3" "3584.2" "3716.6" "4004.5" "3792.3" "3949.9" "5590.1" "4501.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3353104297975983136" "False" "High" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "0.000" "False" "173.872" "50" "24" "67" "24" "534" "60.9" "8.44" "187.51" "24" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.017" "1.017" "0.994" "1.006" "0.995" "0.978" "0.972" "0.959" "1.002" "3814.1" "3879.4" "3880.8" "3792.6" "3837.8" "3794.4" "3730.7" "3706.9" "3659.1" "3823.4" "" "" "" "" "" "" "" "" "" "" "3063.5" "2799.3" "3082.7" "2541.0" "2654.2" "2846.8" "2612.1" "2707.2" "3659.1" "3109.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1534536598926653536" "False" "High" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "0.000" "False" "173.805" "67" "21" "55" "21" "315" "36.1" "5.08" "192.86" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "21" "0" "1.009" "1.031" "0.961" "0.973" "0.986" "0.995" "1.008" "1.007" "1.007" "4887.6" "4930.1" "5036.7" "4695.4" "4753.6" "4818.3" "4861.9" "4928.5" "4920.1" "4922.5" "" "" "" "" "" "" "" "" "" "" "3925.7" "3557.4" "4000.8" "3145.9" "3287.6" "3615.1" "3404.1" "3599.3" "4920.1" "4003.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8623682461858759698" "False" "High" "IsMasterProtein" "P54578" "Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3" "0.000" "False" "173.357" "49" "19" "60" "19" "494" "56.0" "5.30" "212.17" "19" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00443" "9097" "ENSG00000101557" "USP14" "B7Z4N8; hsa:9097; J3QRZ5; P54578; Q53XY5" "Ub-specific processing proteases; Regulation of NF-kappa B signaling" "" "2" "0" "0.983" "0.995" "1.015" "1.005" "0.975" "1.037" "0.991" "0.996" "0.994" "4226.5" "4156.3" "4205.7" "4289.4" "4247.5" "4122.6" "4380.9" "4190.3" "4211.1" "4200.6" "" "" "" "" "" "" "" "" "" "" "3394.7" "2999.0" "3340.7" "2873.9" "2937.6" "3093.1" "3067.3" "3060.2" "4211.1" "3416.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929162783006905550" "False" "High" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "0.000" "False" "173.184" "50" "17" "44" "17" "333" "38.4" "5.80" "170.46" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "ABC-family proteins mediated transport; PKR-mediated signaling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "16" "0" "0.955" "0.949" "0.933" "0.953" "0.926" "0.957" "0.956" "0.917" "0.933" "4556.3" "4351.6" "4325.4" "4253.0" "4341.2" "4216.9" "4360.3" "4357.9" "4179.5" "4249.6" "" "" "" "" "" "" "" "" "" "" "3659.6" "3140.0" "3435.8" "2849.5" "3002.4" "3163.9" "3052.8" "3182.6" "4179.5" "3455.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1304014562382960910" "False" "High" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "0.000" "False" "172.916" "40" "18" "41" "18" "631" "71.6" "4.65" "160.05" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "13" "0" "1.065" "1.044" "1.024" "1.061" "1.039" "1.006" "1.042" "1.047" "1.000" "2422.2" "2580.5" "2527.9" "2481.0" "2569.4" "2515.7" "2436.9" "2523.3" "2535.1" "2422.7" "" "" "" "" "" "" "" "" "" "" "1945.5" "1862.0" "2008.0" "1662.3" "1777.0" "1887.5" "1706.2" "1842.8" "2535.1" "1970.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1687384969150092260" "False" "High" "IsMasterProtein" "Q96B97" "SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2" "0.000" "False" "172.746" "34" "19" "41" "19" "665" "73.1" "6.62" "159.12" "19" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14604" "30011" "ENSG00000147010" "SH3KBP1" "B7Z1D5; hsa:30011; Q5JPT4; Q5JPT5; Q8IWX6; Q8IX98; Q96B97; Q96RN4; Q9NYR0" "Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Reelin signalling pathway" "EGF/EGFR signaling pathway" "9" "0" "1.001" "1.001" "0.989" "1.005" "0.957" "1.008" "1.013" "0.998" "0.977" "3924.8" "3927.1" "3928.3" "3882.5" "3944.0" "3756.1" "3954.8" "3974.5" "3916.3" "3833.6" "" "" "" "" "" "" "" "" "" "" "3152.3" "2833.7" "3120.3" "2601.3" "2727.7" "2818.2" "2769.0" "2902.6" "3916.3" "3117.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8390687985957490189" "False" "High" "IsMasterProtein" "Q5VTR2" "E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2" "0.000" "False" "172.582" "31" "28" "39" "25" "975" "113.6" "5.94" "132.12" "28" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "56254" "ENSG00000155827" "RNF20" "A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83" "E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle" "ATM signaling in development and disease" "3" "3" "1.053" "1.007" "1.044" "1.026" "1.021" "1.026" "1.048" "1.029" "1.045" "2380.4" "2506.8" "2396.7" "2484.4" "2441.6" "2431.3" "2443.4" "2493.9" "2448.3" "2487.5" "" "" "" "" "" "" "" "" "" "" "1911.9" "1808.8" "1903.7" "1664.5" "1688.6" "1824.1" "1710.7" "1821.3" "2448.3" "2022.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074215629290594570" "False" "High" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "0.000" "False" "172.454" "64" "22" "147" "19" "353" "37.4" "8.95" "428.84" "22" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "4" "2" "1.003" "1.019" "1.034" "1.060" "1.053" "1.073" "1.059" "1.049" "1.056" "8309.2" "8334.6" "8467.0" "8593.3" "8807.2" "8748.9" "8915.8" "8803.2" "8715.2" "8777.0" "" "" "" "" "" "" "" "" "" "" "6673.9" "6014.0" "6725.6" "5757.5" "6091.1" "6564.2" "6242.4" "6429.0" "8715.2" "7137.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-797188196996991140" "False" "High" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "0.000" "False" "171.672" "54" "24" "46" "24" "499" "55.7" "5.62" "157.26" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "4" "0" "0.990" "1.006" "0.964" "0.997" "0.982" "0.940" "0.962" "0.950" "0.976" "4472.8" "4428.5" "4500.6" "4310.9" "4458.4" "4390.9" "4206.7" "4301.8" "4250.2" "4363.6" "" "" "" "" "" "" "" "" "" "" "3592.5" "3195.5" "3575.0" "2888.3" "3083.5" "3294.4" "2945.3" "3141.6" "4250.2" "3548.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201863361074030149" "False" "High" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0.000" "False" "171.330" "13" "33" "43" "33" "2799" "309.2" "5.85" "139.68" "33" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "" "Mesodermal commitment pathway" "1" "0" "1.046" "1.038" "1.053" "0.998" "0.987" "0.971" "1.016" "0.971" "1.036" "2148.4" "2247.5" "2230.5" "2261.2" "2143.5" "2121.2" "2086.4" "2182.4" "2085.1" "2226.6" "" "" "" "" "" "" "" "" "" "" "1725.6" "1621.7" "1771.8" "1515.0" "1482.5" "1591.5" "1460.8" "1593.8" "2085.1" "1810.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5272993671693515484" "False" "High" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "0.000" "False" "170.555" "68" "15" "70" "14" "289" "32.6" "5.86" "241.19" "15" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "" "2" "1" "0.966" "0.995" "0.905" "0.924" "0.995" "0.915" "0.915" "0.907" "0.953" "7512.5" "7253.5" "7475.1" "6801.9" "6940.0" "7472.7" "6871.0" "6877.2" "6815.5" "7155.9" "" "" "" "" "" "" "" "" "" "" "6034.0" "5233.9" "5937.7" "4557.2" "4799.7" "5606.7" "4810.7" "5022.4" "6815.5" "5819.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93919318191628628" "False" "High" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "0.000" "False" "170.543" "40" "25" "46" "25" "740" "82.4" "7.23" "167.70" "25" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "tRNA processing in the nucleus" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "3" "0" "0.968" "0.976" "0.970" "1.001" "0.974" "0.988" "0.943" "0.934" "0.950" "4176.3" "4042.6" "4076.1" "4051.1" "4181.8" "4065.8" "4127.6" "3937.3" "3900.9" "3968.1" "" "" "" "" "" "" "" "" "" "" "3354.3" "2917.0" "3237.8" "2714.3" "2892.1" "3050.5" "2890.0" "2875.4" "3900.9" "3227.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-367492356169293166" "False" "High" "IsMasterProtein" "Q12965" "Unconventional myosin-Ie OS=Homo sapiens OX=9606 GN=MYO1E PE=1 SV=2" "0.000" "False" "170.508" "26" "25" "46" "25" "1108" "127.0" "8.92" "152.82" "25" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00063, Pf06017" "4643" "ENSG00000157483" "MYO1E" "hsa:4643; Q12965; Q14778" "" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "2" "0" "1.002" "1.011" "1.005" "1.015" "0.993" "0.992" "1.002" "0.987" "1.011" "4230.2" "4236.8" "4275.5" "4250.9" "4291.5" "4201.9" "4197.2" "4237.1" "4175.6" "4275.1" "" "" "" "" "" "" "" "" "" "" "3397.6" "3057.1" "3396.2" "2848.1" "2968.1" "3152.6" "2938.7" "3094.4" "4175.6" "3476.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7558389581764573434" "False" "High" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "0.000" "False" "170.268" "31" "24" "48" "24" "919" "101.7" "5.62" "181.37" "24" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "14" "0" "1.008" "0.952" "0.979" "0.974" "0.963" "1.021" "1.099" "1.101" "1.023" "4385.6" "4418.6" "4175.2" "4291.4" "4271.8" "4221.5" "4476.6" "4817.9" "4828.4" "4485.3" "" "" "" "" "" "" "" "" "" "" "3522.5" "3188.3" "3316.5" "2875.3" "2954.4" "3167.3" "3134.3" "3518.5" "4828.4" "3647.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5198752139468277763" "False" "High" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "0.000" "False" "169.378" "34" "22" "41" "22" "669" "69.4" "9.67" "146.38" "22" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "RUNX2 regulates bone development" "Ciliary landscape" "2" "0" "1.044" "1.101" "1.036" "1.060" "1.089" "1.054" "1.084" "1.120" "1.074" "2637.7" "2754.0" "2904.9" "2732.5" "2795.3" "2872.5" "2780.4" "2859.9" "2954.8" "2832.0" "" "" "" "" "" "" "" "" "" "" "2118.6" "1987.2" "2307.5" "1830.8" "1933.3" "2155.2" "1946.7" "2088.6" "2954.8" "2303.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936589147855356359" "False" "High" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "0.000" "False" "169.088" "42" "29" "61" "29" "795" "87.2" "7.12" "190.61" "29" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "Mitochondrial protein degradation" "Amino acid metabolism" "2" "0" "1.013" "1.027" "1.048" "1.025" "0.998" "1.001" "1.020" "1.014" "1.005" "5339.6" "5409.2" "5483.1" "5596.5" "5472.3" "5329.4" "5346.9" "5444.4" "5414.4" "5366.5" "" "" "" "" "" "" "" "" "" "" "4288.7" "3903.1" "4355.4" "3749.7" "3784.7" "3998.6" "3743.6" "3976.0" "5414.4" "4364.3" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488092828150113306" "False" "High" "IsMasterProtein" "Q86UX7" "Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1" "0.000" "False" "168.998" "37" "22" "52" "22" "667" "75.9" "6.98" "188.34" "22" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf00373, Pf18124" "83706" "ENSG00000149781" "FERMT3" "hsa:83706; Q86UX7; Q8IUA1; Q8N207; Q9BT48" "Platelet degranulation" "Leukocyte-intrinsic Hippo pathway functions" "2" "0" "0.999" "0.982" "0.930" "0.929" "0.979" "0.893" "0.935" "0.929" "0.933" "5141.9" "5135.6" "5047.6" "4780.7" "4777.7" "5032.8" "4590.6" "4810.0" "4778.4" "4799.3" "" "" "" "" "" "" "" "" "" "" "4129.9" "3705.7" "4009.5" "3203.1" "3304.3" "3776.0" "3214.1" "3512.8" "4778.4" "3902.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6400995593712089390" "False" "High" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "0.000" "False" "168.744" "23" "30" "45" "30" "1555" "177.1" "5.63" "159.98" "30" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "ER Quality Control Compartment (ERQC)" "IL-18 signaling pathway" "2" "0" "1.022" "0.986" "0.995" "0.981" "0.986" "1.016" "1.032" "1.028" "0.990" "4316.1" "4411.9" "4254.3" "4295.7" "4232.1" "4257.3" "4383.4" "4456.1" "4437.2" "4271.8" "" "" "" "" "" "" "" "" "" "" "3466.7" "3183.5" "3379.3" "2878.1" "2926.9" "3194.2" "3069.0" "3254.3" "4437.2" "3474.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917642798524543660" "False" "High" "IsMasterProtein" "P52566" "Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3" "0.000" "False" "168.384" "79" "17" "121" "17" "201" "23.0" "5.21" "383.24" "17" "signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02115" "397" "ENSG00000111348" "ARHGDIB" "B5BU79; hsa:397; P52566" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOH GTPase cycle" "Fas ligand pathway and stress induction of heat shock proteins; Vasopressin-regulated water reabsorption; G13 signaling pathway" "9" "0" "1.021" "1.047" "0.994" "1.028" "1.032" "0.962" "0.987" "1.032" "1.025" "10273.9" "10490.9" "10758.5" "10210.8" "10559.8" "10603.0" "9881.5" "10140.7" "10605.4" "10529.0" "" "" "" "" "" "" "" "" "" "" "8251.9" "7569.9" "8545.8" "6841.2" "7303.3" "7955.2" "6918.5" "7405.8" "10605.4" "8562.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6735907081845110604" "False" "High" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "0.000" "False" "168.192" "27" "24" "41" "24" "958" "108.9" "7.14" "151.94" "24" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "ATF4 activates genes in response to endoplasmic reticulum stress; Major pathway of rRNA processing in the nucleolus and cytosol; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "1.019" "1.028" "0.949" "0.964" "1.014" "0.929" "0.994" "0.989" "0.966" "3541.1" "3607.1" "3638.5" "3360.9" "3412.5" "3588.9" "3291.0" "3519.5" "3501.3" "3422.0" "" "" "" "" "" "" "" "" "" "" "2844.1" "2602.8" "2890.2" "2251.8" "2360.1" "2692.7" "2304.2" "2570.3" "3501.3" "2782.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369524592651400068" "False" "High" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "0.000" "False" "167.982" "49" "22" "53" "22" "491" "55.5" "7.15" "199.26" "22" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "9" "0" "0.952" "1.002" "0.928" "0.946" "0.976" "0.914" "0.957" "0.932" "0.963" "6150.6" "5853.5" "6161.7" "5707.7" "5818.8" "6005.5" "5621.9" "5888.9" "5732.3" "5922.6" "" "" "" "" "" "" "" "" "" "" "4940.1" "4223.7" "4894.5" "3824.2" "4024.3" "4505.9" "3936.2" "4300.6" "5732.3" "4816.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8029242028913948624" "False" "High" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "0.000" "False" "167.316" "17" "31" "39" "31" "2054" "233.0" "6.30" "139.72" "31" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00595, Pf01576" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "" "3" "0" "0.971" "1.012" "1.116" "1.078" "1.027" "1.151" "1.065" "1.042" "1.089" "2970.1" "2883.2" "3007.2" "3314.4" "3201.0" "3048.9" "3418.0" "3161.9" "3095.2" "3233.8" "" "" "" "" "" "" "" "" "" "" "2385.5" "2080.4" "2388.7" "2220.6" "2213.8" "2287.5" "2393.1" "2309.1" "3095.2" "2629.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6441918618070782743" "False" "High" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "0.000" "False" "167.018" "16" "25" "45" "25" "2035" "208.6" "7.46" "169.69" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415, Pf13854" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "Mitochondrial gene expression; Pleural mesothelioma" "6" "0" "1.012" "1.016" "0.993" "0.972" "0.969" "0.923" "0.985" "0.978" "0.979" "3417.9" "3458.5" "3473.9" "3394.8" "3322.1" "3313.3" "3155.0" "3365.9" "3343.0" "3344.9" "" "" "" "" "" "" "" "" "" "" "2745.2" "2495.5" "2759.4" "2274.5" "2297.6" "2485.9" "2209.0" "2458.2" "3343.0" "2720.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4754969911618934256" "False" "High" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "0.000" "False" "166.275" "33" "24" "37" "23" "873" "97.6" "4.60" "139.08" "24" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "1" "1.035" "1.004" "1.013" "1.005" "1.012" "1.001" "1.003" "0.977" "0.969" "4134.7" "4277.8" "4153.3" "4186.5" "4154.0" "4185.6" "4139.9" "4146.6" "4039.5" "4006.9" "" "" "" "" "" "" "" "" "" "" "3320.9" "3086.7" "3299.1" "2804.9" "2872.9" "3140.4" "2898.5" "3028.3" "4039.5" "3258.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088102652964782572" "False" "High" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "0.000" "False" "165.959" "36" "21" "58" "15" "644" "70.7" "9.26" "202.14" "21" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "0.995" "1.013" "0.967" "1.005" "1.007" "0.978" "1.008" "0.977" "1.000" "4538.5" "4513.7" "4598.4" "4388.1" "4560.1" "4569.8" "4436.7" "4574.3" "4433.9" "4536.9" "" "" "" "" "" "" "" "" "" "" "3645.2" "3256.9" "3652.6" "2940.0" "3153.8" "3428.6" "3106.3" "3340.7" "4433.9" "3689.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405603430523799899" "False" "High" "IsMasterProtein" "P52888" "Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2" "0.000" "False" "165.804" "45" "31" "61" "31" "689" "78.8" "6.05" "206.54" "31" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01432" "7064" "ENSG00000172009" "THOP1" "B3KSE2; hsa:7064; P52888; Q9UCB3" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.980" "0.978" "0.995" "0.969" "0.987" "0.990" "0.960" "0.969" "0.977" "6972.5" "6834.4" "6820.8" "6936.9" "6754.7" "6882.3" "6906.1" "6694.4" "6754.5" "6815.0" "" "" "" "" "" "" "" "" "" "" "5600.3" "4931.5" "5418.0" "4647.7" "4671.6" "5163.6" "4835.3" "4888.9" "6754.5" "5542.2" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982542769367786087" "False" "High" "IsMasterProtein" "O75116" "Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4" "0.000" "False" "165.777" "27" "34" "45" "29" "1388" "160.8" "6.02" "148.51" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "9475" "ENSG00000134318" "ROCK2" "hsa:9475; O75116; Q53QZ0; Q53SJ7; Q9UQN5" "Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "27" "0" "0.973" "0.958" "0.979" "0.952" "0.959" "0.961" "0.944" "1.002" "0.982" "3534.9" "3440.2" "3387.0" "3459.9" "3363.5" "3390.7" "3396.0" "3335.2" "3540.5" "3472.0" "" "" "" "" "" "" "" "" "" "" "2839.2" "2482.4" "2690.4" "2318.1" "2326.2" "2544.0" "2377.7" "2435.7" "3540.5" "2823.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4598318327767700223" "False" "High" "IsMasterProtein" "Q96SI9" "Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1" "0.000" "False" "165.462" "40" "28" "46" "22" "672" "73.6" "8.72" "154.53" "28" "other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf00035, Pf07528, Pf20965" "55342" "ENSG00000165209" "STRBP" "hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4" "" "" "0" "0" "0.983" "0.997" "0.986" "1.016" "0.990" "0.921" "1.031" "1.017" "1.001" "2577.7" "2534.5" "2570.1" "2541.2" "2618.7" "2550.9" "2373.3" "2657.9" "2620.8" "2581.5" "" "" "" "" "" "" "" "" "" "" "2070.4" "1828.8" "2041.5" "1702.6" "1811.1" "1913.9" "1661.7" "1941.1" "2620.8" "2099.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7644877244443849971" "False" "High" "IsMasterProtein" "Q13177" "Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3" "0.000" "False" "165.403" "46" "19" "59" "14" "524" "58.0" "5.96" "195.10" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5062" "ENSG00000180370" "PAK2" "hsa:5062; Q13154; Q13177; Q6ISC3" "FCERI mediated MAPK activation; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; RHOU GTPase cycle; Nef and signal transduction; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Ephrin signaling; Sema3A PAK dependent Axon repulsion; Smooth Muscle Contraction; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Stimulation of the cell death response by PAK-2p34" "Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway" "45" "3" "0.994" "0.995" "0.968" "1.019" "0.978" "1.005" "1.030" "1.014" "0.999" "6504.7" "6464.6" "6470.6" "6295.2" "6628.8" "6363.8" "6535.7" "6699.1" "6592.8" "6496.1" "" "" "" "" "" "" "" "" "" "" "5224.5" "4664.7" "5139.8" "4217.8" "4584.6" "4774.7" "4576.0" "4892.3" "6592.8" "5282.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6066576864868279087" "False" "High" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "0.000" "False" "164.765" "35" "22" "38" "22" "795" "87.1" "6.37" "145.50" "22" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "0.949" "0.973" "0.973" "0.943" "0.926" "0.938" "0.972" "0.931" "0.955" "3871.7" "3676.0" "3767.2" "3766.7" "3652.0" "3585.1" "3631.3" "3762.4" "3604.0" "3697.7" "" "" "" "" "" "" "" "" "" "" "3109.7" "2652.5" "2992.4" "2523.7" "2525.7" "2689.8" "2542.5" "2747.7" "3604.0" "3007.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8788439396421035672" "False" "High" "IsMasterProtein" "Q92621" "Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3" "0.000" "False" "164.719" "14" "25" "38" "25" "2012" "227.8" "6.19" "127.82" "25" "cell organization and biogenesis;transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf11894" "23165" "ENSG00000155561" "NUP205" "A6H8X3; hsa:23165; Q86YC1; Q92621" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "29" "0" "1.049" "1.028" "1.045" "1.034" "1.032" "0.962" "1.117" "1.114" "1.015" "3570.2" "3745.2" "3669.7" "3731.4" "3691.7" "3683.5" "3434.7" "3989.5" "3978.0" "3622.5" "" "" "" "" "" "" "" "" "" "" "2867.5" "2702.4" "2915.0" "2500.0" "2553.2" "2763.6" "2404.8" "2913.6" "3978.0" "2945.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2921825731244054349" "False" "High" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "0.000" "False" "164.609" "79" "14" "53" "14" "261" "26.9" "7.78" "178.07" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Branched-chain amino acid catabolism; Mitochondrial protein degradation; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "8" "0" "1.002" "0.981" "1.063" "1.047" "0.992" "1.053" "1.024" "0.976" "1.017" "2661.6" "2665.9" "2610.5" "2830.6" "2786.7" "2639.4" "2802.0" "2725.5" "2598.7" "2708.1" "" "" "" "" "" "" "" "" "" "" "2137.8" "1923.6" "2073.6" "1896.5" "1927.3" "1980.3" "1961.8" "1990.4" "2598.7" "2202.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5526079506929447963" "False" "High" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "0.000" "False" "164.072" "21" "22" "40" "22" "1153" "130.1" "8.48" "151.78" "22" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "1.025" "0.989" "0.969" "0.972" "1.002" "0.946" "1.005" "0.958" "1.016" "3054.6" "3129.7" "3019.8" "2958.7" "2969.4" "3061.6" "2890.6" "3068.9" "2925.2" "3103.3" "" "" "" "" "" "" "" "" "" "" "2453.4" "2258.3" "2398.8" "1982.4" "2053.7" "2297.1" "2023.8" "2241.2" "2925.2" "2523.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144982604897555779" "False" "High" "IsMasterProtein" "P52306" "Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3" "0.000" "False" "164.035" "39" "21" "47" "20" "607" "66.3" "5.31" "167.36" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus" "enzyme regulator activity" "Pf00514" "5910" "ENSG00000138698" "RAP1GDS1" "E9PH06; G5E9P9; hsa:5910; P52306; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8" "RHOT2 GTPase cycle; RHOT1 GTPase cycle" "" "2" "0" "0.985" "0.946" "0.976" "0.968" "0.957" "1.001" "0.966" "0.965" "0.978" "4301.7" "4235.7" "4067.7" "4198.0" "4166.0" "4116.3" "4304.7" "4155.3" "4150.0" "4208.0" "" "" "" "" "" "" "" "" "" "" "3455.1" "3056.3" "3231.1" "2812.7" "2881.2" "3088.4" "3013.9" "3034.7" "4150.0" "3422.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5868182849043771837" "False" "High" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "0.000" "False" "163.796" "39" "13" "47" "13" "440" "48.1" "5.08" "170.16" "13" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "XBP1(S) activates chaperone genes; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "5" "0" "0.973" "0.967" "0.948" "0.999" "1.012" "1.030" "1.030" "1.051" "1.018" "3059.8" "2975.9" "2960.3" "2901.6" "3056.6" "3097.3" "3150.1" "3150.6" "3216.7" "3114.7" "" "" "" "" "" "" "" "" "" "" "2457.6" "2147.3" "2351.5" "1944.1" "2113.9" "2323.8" "2205.5" "2300.9" "3216.7" "2533.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6890831805190457766" "False" "High" "IsMasterProtein" "Q9BV73" "Centrosome-associated protein CEP250 OS=Homo sapiens OX=9606 GN=CEP250 PE=1 SV=2" "0.000" "False" "163.792" "15" "33" "38" "33" "2442" "281.0" "5.02" "129.79" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15035" "11190" "ENSG00000126001" "CEP250" "E1P5Q3; hsa:11190; O14812; O60588; Q9BV73; Q9H450" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Mesodermal commitment pathway" "8" "0" "1.036" "1.061" "1.062" "1.069" "1.066" "1.032" "0.996" "1.062" "1.067" "1862.6" "1928.8" "1976.4" "1978.2" "1991.8" "1986.4" "1922.0" "1854.8" "1978.3" "1987.5" "" "" "" "" "" "" "" "" "" "" "1496.0" "1391.8" "1569.9" "1325.4" "1377.5" "1490.4" "1345.7" "1354.5" "1978.3" "1616.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269209104434095274" "False" "High" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "0.000" "False" "163.775" "49" "23" "64" "23" "531" "58.0" "6.68" "202.35" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "1.015" "1.028" "1.015" "1.001" "0.948" "0.994" "0.977" "0.973" "0.968" "5810.9" "5895.3" "5971.4" "5899.1" "5818.3" "5510.0" "5775.7" "5674.7" "5653.0" "5624.3" "" "" "" "" "" "" "" "" "" "" "4667.3" "4253.9" "4743.3" "3952.4" "4024.0" "4134.0" "4043.8" "4144.3" "5653.0" "4573.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4137218576109141814" "False" "High" "IsMasterProtein" "Q06210" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3" "0.000" "False" "163.390" "43" "25" "41" "25" "699" "78.8" "7.11" "143.34" "25" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "2673" "ENSG00000198380" "GFPT1" "hsa:2673; Q06210; Q53QE6; Q9BXF8" "XBP1(S) activates chaperone genes; Synthesis of UDP-N-acetyl-glucosamine; Defective GFPT1 causes CMSTA1" "UDP-derived sugars synthesis in fibroblasts" "4" "0" "0.996" "1.005" "0.957" "0.961" "0.964" "0.965" "0.946" "0.987" "0.994" "2456.9" "2447.3" "2468.2" "2352.0" "2361.8" "2368.6" "2370.8" "2325.1" "2424.6" "2442.0" "" "" "" "" "" "" "" "" "" "" "1973.4" "1765.9" "1960.5" "1575.9" "1633.4" "1777.1" "1659.9" "1698.0" "2424.6" "1985.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9142633453092605073" "False" "High" "IsMasterProtein" "Cont_P63103" "14-3-3 protein zeta/delta OS=Bos taurus OX=9913 GN=YWHAZ PE=1 SV=1" "0.000" "True" "163.356" "71" "17" "167" "10" "245" "27.7" "4.79" "488.13" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "100030704; 100056060; 100127113; 100173609; 100411134; 100484483; 100596460; 100672224; 100727182; 100913480; 100977477; 101012101; 101021050; 101151099; 101331119; 101351914; 101384625; 101687663; 101721954; 101968271; 102019696; 102115184; 102175223; 102283808; 102742022; 102765675; 103004481; 103085559; 103121925; 103191924; 103261347; 103732836; 105005492; 105302907; 105476048; 105504209; 105542098; 105586543; 105719669; 105869900; 106847839; 107142838; 107512228; 109277999; 109382800; 109568481; 109697135; 287022; 472830; 475864; 709723; 7534; 780440" "ENSAMEG00000000328; ENSANAG00000027160; ENSBGRG00000009704; ENSBIXG00000019500; ENSBIXG00005001276; ENSBMSG00010017904; ENSBTAG00000000236; ENSCAFG00000000580; ENSCAFG00845028920; ENSCANG00000043345; ENSCATG00000024186; ENSCCAG00000037757; ENSCCNG00000015730; ENSCHIG00000020223; ENSCJAG00000015844; ENSCLAG00000004303; ENSCPOG00000040522; ENSCWAG00000015721; ENSDLEG00000002530; ENSEASG00005002806; ENSECAG00000021882; ENSFCAG00000037073; ENSG00000164924; ENSGGOG00000022133; ENSHGLG00100048437; ENSLAFG00000004944; ENSMFAG00000001740; ENSMICG00000034946; ENSMLEG00000033187; ENSMMMG00000016188; ENSMMNG00015011551; ENSMMSG00000002669; ENSMMUG00000006489; ENSMNEG00000041365; ENSMODG00000006158; ENSMPUG00000015158; ENSNGAG00000006289; ENSNLEG00000030006; ENSPANG00000010317; ENSPANG00000042694; ENSPEMG00000021714; ENSPPAG00000038734; ENSPPYG00000018791; ENSPSMG00000012736; ENSPSNG00000018640; ENSPTEG00000005862; ENSPTIG00000021410; ENSPTRG00000048115; ENSRFEG00010019368; ENSSBOG00000021820; ENSSDAG00000019504; ENSSHAG00000012671; ENSSSCG00000006062; ENSSSCG00015031811; ENSSSCG00025071491; ENSSSCG00035013965; ENSSSCG00045030109; ENSSSCG00050034502; ENSSSCG00055001784; ENSSSCG00060049326; ENSSSCG00070011887; ENSSSUG00005013206; ENSSTOG00000023864; ENSSVLG00005003330; ENSTSYG00000026493; ENSTTRG00000015906; ENSUAMG00000024432; ENSUMAG00000017568; ENSVURG00010007014; ENSVVUG00000013173" "LOC101351914; LOC111146608; Ywhaz; YWHAZ" "A0A096NQ71; A0A097C2Z1; A0A1D5QAJ7; A0A1S3ABR1; A0A1U7TL92; A0A250XWX3; A0A286XIL7; A0A2I2UD77; A0A2I3GBB0; A0A2J8PMJ1; A0A2J8UFH0; A0A2K5DCH7; A0A2K5KE38; A0A2K5L5H7; A0A2K5SHP3; A0A2K5TVK5; A0A2K5YR93; A0A2K6DL02; A0A2K6SRG4; A0A2R9BQD0; A0A2U3W322; A0A2U3YQG6; A0A2U4AHZ7; A0A2Y9GYG0; A0A2Y9JAB1; A0A2Y9PAR8; A0A2Y9QK13; A0A340XXA5; A0A344MNR9; A0A383ZE89; A0A384BYY2; A0A3Q7NYD6; A0A3Q7S418; A0A452SHE3; A0A480PLY3; A0A4W2CSD8; A0A4X1TV95; A0A4X2KB08; A0A518J2H6; A0A5E4AK25; A0A671FTZ7; A0A673UG86; A0A6B0SHT8; A0A6D2XVW1; A0A6J0W154; A0A6J1ZUX6; A0A6J2B9D9; A0A6J2NBP1; A0A6J3FPA9; A0A6P3J5F7; A0A6P3R2S0; A0A6P5CUI6; A0A6P5ISH5; A0A6P6HS74; A0A7J7TL19; A0A7J7VNU9; A0A7J8C4Y7; A0A7J8DUV8; A0A7N4P7P6; A0A7N5KS25; A0A8B6ZD59; A0A8B7G6A9; A0A8B7RAL2; A0A8B8VLP3; A0A8B9X1D7; A0A8C2UZS6; A0A8C3WSB1; A0A8C4KZ72; A0A8C5ZR25; A0A8C6BH51; A0A8C6CXQ8; A0A8C6QKN2; A0A8C8U9V5; A0A8C8ZIR5; A0A8C9E7Q2; A0A8C9GP54; A0A8C9KQT4; A0A8C9Q7D7; A0A8D2CLR5; A0A8I3Q1P7; A0A8J8XBY4; A0A8J8Y9Q2; A0A8P0S6K0; A0A9V1GJ83; A0A9X9LZ30; A8K1N0; aju:106980045; aml:100484483; B7Z465; bacu:103004481; bbis:105005492; biu:109568481; bom:102283808; bta:287022; cang:105504209; caty:105586543; ccan:109697135; cfa:475864; chx:102175223; cjc:100411134; cpoc:100727182; csyr:103261347; D0PNI1; dle:111180376; elk:111146608; F6XEB4; F7BS95; F7EFF6; F7G9D2; F7HBD4; fca:100127113; G3RS45; G3SV87; G5AP01; G7MZV8; G7PCF6; ggo:101151099; hai:109382800; hgl:101721954; hsa:7534; I3N206; K7DDM2; L5M3G8; lav:100672224; lve:103085559; lww:102742022; M3WVC7; M3YUN9; mcc:709723; mcf:102115184; mdo:100030704; mleu:105542098; mmur:105869900; mni:105476048; mpuf:101687663; myd:102765675; ngi:103732836; nle:100596460; nsu:110579154; oro:101384625; P29213; P29312; P63103; P63104; panu:101012101; panu:101021050; pcoo:112859599; pcw:110196285; pdic:114514896; pon:100173609; pps:100977477; ptg:102966103; ptr:472830; pvp:105302907; Q32P43; Q3ZCF9; Q5R651; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; ray:107512228; sbq:101047958; shr:100913480; tmu:101351914; U3E3R3; umr:103661509; vvp:112916971; zca:113910054" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Metabolic Genes; Interleukin-3, Interleukin-5 and GM-CSF signaling; Activation of BAD and translocation to mitochondria ; Rap1 signalling; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Negative regulation of NOTCH4 signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling" "Calcium regulation in cardiac cell; Cell cycle; Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; SIDS susceptibility pathways; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Calcium regulation in cardiac cells" "40" "3" "1.015" "0.996" "0.948" "0.975" "1.031" "0.972" "0.936" "1.014" "0.988" "8194.0" "8314.5" "8162.2" "7767.3" "7990.9" "8445.4" "7968.0" "7668.9" "8309.6" "8097.6" "" "" "" "" "" "" "" "" "" "" "6581.4" "5999.5" "6483.5" "5204.1" "5526.5" "6336.5" "5578.8" "5600.6" "8309.6" "6585.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1567690974661695744" "False" "High" "IsMasterProtein" "Q9NY65" "Tubulin alpha-8 chain OS=Homo sapiens OX=9606 GN=TUBA8 PE=1 SV=1" "0.000" "False" "163.261" "35" "13" "119" "1" "449" "50.1" "5.06" "379.67" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "51807" "ENSG00000183785" "TUBA8" "B2RCX2; B3KPW9; B4DWG3; hsa:51807; Q2M3N4; Q9NY65" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; PKR-mediated signaling; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; HCMV Early Events; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Recycling pathway of L1; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "32" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938619972574952291" "False" "High" "IsMasterProtein" "Q9ULW0" "Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2" "0.000" "False" "163.240" "35" "23" "40" "23" "747" "85.6" "9.23" "152.07" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06886, Pf09041, Pf12214" "22974" "ENSG00000088325" "TPX2" "hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1" "Regulation of TP53 Activity through Phosphorylation; AURKA Activation by TPX2" "Gastric cancer network 1" "3" "0" "1.021" "1.020" "1.015" "0.998" "0.995" "1.101" "1.128" "1.103" "1.022" "3019.5" "3083.8" "3078.6" "3065.2" "3012.1" "3005.3" "3324.7" "3406.5" "3331.5" "3084.4" "" "" "" "" "" "" "" "" "" "" "2425.2" "2225.2" "2445.4" "2053.7" "2083.2" "2254.9" "2327.8" "2487.8" "3331.5" "2508.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4945442823809026460" "False" "High" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "0.000" "False" "163.176" "57" "16" "46" "16" "308" "33.4" "5.69" "171.88" "16" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "Cytosolic sulfonation of small molecules" "" "1" "0" "0.994" "1.037" "0.975" "1.035" "0.998" "0.952" "0.991" "0.980" "0.994" "4297.9" "4273.0" "4459.0" "4190.6" "4448.9" "4291.0" "4092.6" "4258.5" "4211.7" "4273.0" "" "" "" "" "" "" "" "" "" "" "3452.0" "3083.3" "3541.9" "2807.7" "3076.9" "3219.5" "2865.4" "3110.0" "4211.7" "3475.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5211801014996619812" "False" "High" "IsMasterProtein" "O43143" "ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "0.000" "False" "163.036" "37" "27" "53" "26" "795" "90.9" "7.46" "166.70" "27" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.984" "1.040" "1.061" "1.034" "1.001" "1.031" "1.003" "1.018" "1.027" "3120.2" "3069.3" "3245.9" "3310.9" "3224.8" "3123.4" "3216.2" "3130.1" "3176.9" "3205.7" "" "" "" "" "" "" "" "" "" "" "2506.1" "2214.7" "2578.3" "2218.3" "2230.3" "2343.5" "2251.8" "2285.9" "3176.9" "2607.0" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028691531671689044" "False" "High" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "0.000" "False" "163.034" "33" "28" "47" "28" "944" "106.8" "6.14" "168.01" "28" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802, Pf21365" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "N-glycan biosynthesis" "5" "0" "0.999" "0.952" "0.961" "0.997" "1.006" "0.978" "1.004" "1.035" "1.001" "3048.6" "3046.2" "2901.2" "2928.5" "3038.4" "3066.5" "2982.1" "3059.4" "3154.3" "3050.6" "" "" "" "" "" "" "" "" "" "" "2448.6" "2198.1" "2304.5" "1962.1" "2101.4" "2300.8" "2087.9" "2234.3" "3154.3" "2480.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-253239951813173210" "False" "High" "IsMasterProtein" "Q9H2M9" "Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1" "0.000" "False" "162.853" "23" "29" "44" "28" "1393" "155.9" "5.62" "146.24" "29" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf14655, Pf14656" "25782" "ENSG00000118873" "RAB3GAP2" "A6H8V0; hsa:25782; O75872; Q9H2M9; Q9HAB0; Q9UFJ7; Q9UQ15" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "" "2" "1" "1.078" "1.000" "1.027" "1.007" "0.985" "0.948" "1.020" "0.968" "1.024" "3089.7" "3332.2" "3089.1" "3174.3" "3111.0" "3044.0" "2928.8" "3151.5" "2989.9" "3164.2" "" "" "" "" "" "" "" "" "" "" "2481.6" "2404.4" "2453.8" "2126.8" "2151.6" "2283.8" "2050.6" "2301.5" "2989.9" "2573.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4287058177622287432" "False" "High" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "0.000" "False" "162.618" "34" "25" "43" "21" "839" "94.5" "5.88" "149.28" "25" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "1.002" "0.990" "1.032" "1.013" "1.001" "1.001" "1.002" "0.987" "1.014" "2704.0" "2709.6" "2676.8" "2790.5" "2738.5" "2706.0" "2706.7" "2710.7" "2667.7" "2742.0" "" "" "" "" "" "" "" "" "" "" "2171.8" "1955.1" "2126.3" "1869.6" "1894.0" "2030.3" "1895.1" "1979.6" "2667.7" "2229.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031077161766424227" "False" "High" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "0.000" "False" "162.543" "43" "27" "36" "27" "841" "95.9" "5.11" "133.29" "27" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400; ENSG00000292219" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "0.978" "0.961" "0.998" "1.023" "0.968" "0.975" "0.979" "1.001" "1.023" "2360.5" "2308.5" "2269.4" "2356.8" "2415.6" "2283.9" "2302.4" "2311.8" "2361.9" "2414.0" "" "" "" "" "" "" "" "" "" "" "1895.9" "1665.8" "1802.7" "1579.0" "1670.6" "1713.6" "1612.0" "1688.3" "2361.9" "1963.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972522835468462088" "False" "High" "IsMasterProtein" "O43432" "Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2" "0.000" "False" "162.306" "23" "33" "48" "27" "1585" "176.5" "5.38" "157.54" "33" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "8672" "ENSG00000075151" "EIF4G3" "B9EGQ7; hsa:8672; O43432; Q15597; Q504Z1; Q5SWC3; Q8NEN1" "ISG15 antiviral mechanism" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "3" "0" "1.033" "0.952" "1.074" "1.030" "0.974" "0.967" "0.971" "0.967" "0.989" "3099.7" "3203.0" "2951.3" "3327.7" "3191.3" "3019.5" "2996.2" "3009.9" "2997.2" "3066.9" "" "" "" "" "" "" "" "" "" "" "2489.6" "2311.2" "2344.3" "2229.5" "2207.2" "2265.5" "2097.8" "2198.1" "2997.2" "2494.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5288684708523747991" "False" "High" "IsMasterProtein" "Q14240" "Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2" "0.000" "False" "162.121" "49" "20" "60" "10" "407" "46.4" "5.48" "216.55" "20" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1974" "ENSG00000156976" "EIF4A2" "D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Translation initiation complex formation; Ribosomal scanning and start codon recognition; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "11" "0" "0.965" "1.018" "0.948" "0.961" "1.000" "0.918" "0.975" "0.974" "0.994" "1682.4" "1623.1" "1712.3" "1594.4" "1616.5" "1682.3" "1545.3" "1641.0" "1637.9" "1672.3" "" "" "" "" "" "" "" "" "" "" "1351.3" "1171.2" "1360.2" "1068.2" "1118.0" "1262.2" "1081.9" "1198.4" "1637.9" "1360.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1422761924457517511" "False" "High" "IsMasterProtein" "A3KN83" "Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1" "0.000" "False" "161.927" "23" "25" "34" "25" "1393" "154.2" "7.88" "115.68" "25" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "55206" "ENSG00000139697" "SBNO1" "A3KN83; Q05C06; Q3ZTS3; Q9H3T8; Q9NVB2" "" "" "0" "0" "1.063" "1.047" "1.140" "1.127" "1.038" "1.037" "1.111" "1.022" "1.103" "1472.1" "1564.9" "1541.4" "1678.8" "1658.9" "1528.6" "1527.0" "1635.3" "1504.3" "1623.2" "" "" "" "" "" "" "" "" "" "" "1182.4" "1129.2" "1224.4" "1124.8" "1147.3" "1146.9" "1069.1" "1194.3" "1504.3" "1320.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6086246065885053041" "False" "High" "IsMasterProtein" "Cont_P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "0.000" "True" "161.824" "57" "26" "45" "9" "472" "51.5" "5.16" "145.77" "26" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Formation of the cornified envelope; Type I hemidesmosome assembly" "Corticotropin-releasing hormone signaling pathway" "4" "8" "0.420" "0.092" "0.212" "0.253" "0.371" "0.872" "0.261" "0.287" "0.421" "7723.4" "3247.7" "710.7" "1636.2" "1956.0" "2867.8" "6735.9" "2019.1" "2215.2" "3250.7" "" "" "" "" "" "" "" "" "" "" "6203.4" "2343.4" "564.5" "1096.3" "1352.8" "2151.7" "4716.2" "1474.6" "2215.2" "2643.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4081821255654730279" "False" "High" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "0.000" "False" "161.211" "34" "25" "44" "25" "768" "88.9" "8.48" "141.06" "25" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Hedgehog 'on' state; Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of DVL; Regulation of RAS by GAPs; Neddylation; KEAP1-NFE2L2 pathway; RHOBTB3 ATPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "16" "0" "0.990" "1.012" "0.968" "0.967" "0.965" "0.963" "0.959" "0.973" "0.989" "2784.3" "2757.2" "2817.2" "2695.8" "2692.1" "2687.6" "2682.1" "2669.8" "2709.7" "2754.6" "" "" "" "" "" "" "" "" "" "" "2236.3" "1989.5" "2237.8" "1806.2" "1861.9" "2016.4" "1877.8" "1949.8" "2709.7" "2240.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887047081584333281" "False" "High" "IsMasterProtein" "P54652" "Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1" "0.000" "False" "160.946" "26" "18" "156" "2" "639" "70.0" "5.74" "489.39" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "3306" "ENSG00000126803" "HSPA2" "hsa:3306; P54652; Q15508; Q53XM3; Q9UE78" "Regulation of HSF1-mediated heat shock response; Meiotic synapsis; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Attenuation phase" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection; 7q11.23 copy number variation syndrome; Urotensin-II-mediated signaling pathway" "10" "0" "1.227" "1.212" "1.271" "1.073" "1.052" "1.147" "0.894" "1.129" "1.373" "55.7" "68.3" "67.5" "70.8" "59.8" "58.6" "63.9" "49.8" "62.9" "76.5" "" "" "" "" "" "" "" "" "" "" "44.7" "49.3" "53.6" "47.4" "41.3" "43.9" "44.7" "36.3" "62.9" "62.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654081652263858131" "False" "High" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "0.000" "False" "160.860" "50" "15" "51" "15" "390" "43.0" "5.26" "182.23" "15" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07528, Pf20965" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "Neutrophil degranulation; PKR-mediated signaling" "B cell receptor signaling pathway" "3" "0" "0.981" "1.033" "0.980" "0.993" "1.019" "0.991" "1.033" "0.980" "1.008" "2850.0" "2795.6" "2943.7" "2791.6" "2830.0" "2903.3" "2823.9" "2944.6" "2792.0" "2873.5" "" "" "" "" "" "" "" "" "" "" "2289.1" "2017.3" "2338.2" "1870.4" "1957.2" "2178.3" "1977.2" "2150.4" "2792.0" "2336.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618262664170988145" "False" "High" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "0.000" "False" "160.804" "43" "19" "90" "19" "463" "50.9" "5.54" "239.47" "19" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "HCMV Late Events; SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "6" "0" "1.019" "1.016" "0.994" "0.984" "1.005" "0.948" "0.943" "1.000" "0.979" "6700.1" "6825.2" "6807.7" "6663.0" "6593.7" "6730.7" "6353.4" "6317.3" "6701.3" "6562.2" "" "" "" "" "" "" "" "" "" "" "5381.5" "4924.9" "5407.6" "4464.2" "4560.3" "5049.9" "4448.3" "4613.6" "6701.3" "5336.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-537602968940689111" "False" "High" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "0.000" "False" "160.625" "41" "21" "54" "15" "589" "65.3" "5.11" "170.60" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Negative regulation of MAPK pathway; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "50" "5" "0.976" "0.986" "1.001" "0.961" "0.946" "0.974" "0.958" "0.958" "0.950" "4237.9" "4136.4" "4178.4" "4242.9" "4070.5" "4007.8" "4127.0" "4061.2" "4060.6" "4024.7" "" "" "" "" "" "" "" "" "" "" "3403.8" "2984.7" "3319.0" "2842.7" "2815.2" "3006.9" "2889.5" "2965.9" "4060.6" "3273.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6919500497101416540" "False" "High" "IsMasterProtein" "Q9UJU6" "Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1" "0.000" "False" "160.456" "49" "16" "56" "16" "430" "48.2" "5.05" "194.82" "16" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241, Pf14604" "28988" "ENSG00000136279" "DBNL" "A4D2I9; B4DDP6; B4DEM2; C9J7P1; hsa:28988; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; Q9UJU6" "Neutrophil degranulation; Neurexins and neuroligins; Caspase-mediated cleavage of cytoskeletal proteins" "T-cell receptor signaling pathway" "4" "0" "1.006" "1.007" "0.963" "0.988" "0.992" "0.978" "0.974" "0.998" "0.989" "4820.1" "4848.7" "4853.2" "4641.3" "4760.9" "4781.6" "4715.1" "4694.8" "4812.0" "4765.9" "" "" "" "" "" "" "" "" "" "" "3871.5" "3498.7" "3855.1" "3109.7" "3292.7" "3587.6" "3301.3" "3428.6" "4812.0" "3875.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4840156573364048016" "False" "High" "IsMasterProtein" "Q58FF7" "Putative heat shock protein HSP 90-beta-3 OS=Homo sapiens OX=9606 GN=HSP90AB3P PE=5 SV=1" "0.000" "False" "160.392" "29" "22" "190" "1" "597" "68.3" "4.79" "560.47" "22" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00183" "" "" "HSP90AB3P" "Q58FF7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1853475733980272119" "False" "High" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "0.000" "False" "159.803" "34" "20" "43" "16" "780" "85.0" "7.50" "173.32" "20" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Glycolysis; Neutrophil degranulation" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "9" "0" "1.067" "1.020" "1.064" "1.022" "1.027" "0.984" "0.997" "0.955" "1.051" "1730.5" "1846.8" "1765.4" "1841.6" "1767.9" "1776.7" "1703.5" "1724.6" "1653.0" "1819.3" "" "" "" "" "" "" "" "" "" "" "1389.9" "1332.6" "1402.3" "1233.9" "1222.7" "1333.0" "1192.7" "1259.5" "1653.0" "1479.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1811724669038293962" "False" "High" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "0.000" "False" "158.770" "36" "24" "55" "24" "751" "83.4" "7.01" "183.28" "24" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "Mitochondrial translation elongation" "" "1" "0" "0.967" "0.968" "0.897" "0.955" "0.971" "0.884" "0.941" "0.915" "0.952" "6118.6" "5919.7" "5924.0" "5490.0" "5841.4" "5939.7" "5409.8" "5754.6" "5599.2" "5821.9" "" "" "" "" "" "" "" "" "" "" "4914.4" "4271.5" "4705.6" "3678.3" "4040.0" "4456.4" "3787.6" "4202.6" "5599.2" "4734.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3533447776593040930" "False" "High" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=2" "0.000" "False" "158.653" "33" "15" "42" "12" "557" "59.6" "9.16" "174.43" "15" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "5725" "ENSG00000011304" "PTBP1" "hsa:5725; P26599; Q9BUQ0" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "mir-124 predicted interactions with cell cycle and differentiation ; mRNA processing" "5" "2" "1.065" "1.021" "1.032" "1.089" "0.978" "1.040" "1.111" "1.029" "1.048" "1998.7" "2128.4" "2041.4" "2062.1" "2177.3" "1954.3" "2078.5" "2220.2" "2056.5" "2094.2" "" "" "" "" "" "" "" "" "" "" "1605.3" "1535.8" "1621.5" "1381.6" "1505.9" "1466.2" "1455.2" "1621.4" "2056.5" "1703.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5359713146649655482" "False" "High" "IsMasterProtein" "P31150" "Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2" "0.000" "False" "158.423" "52" "19" "46" "12" "447" "50.6" "5.14" "161.94" "19" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2664" "ENSG00000203879" "GDI1" "hsa:2664; P31150; P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6" "RAB GEFs exchange GTP for GDP on RABs" "Ciliary landscape; Airway smooth muscle cell contraction" "3" "0" "0.969" "1.007" "0.977" "1.010" "1.026" "0.931" "0.979" "0.968" "0.991" "1717.8" "1664.3" "1729.8" "1678.7" "1734.9" "1762.6" "1599.2" "1681.3" "1663.1" "1702.5" "" "" "" "" "" "" "" "" "" "" "1379.7" "1200.9" "1374.0" "1124.7" "1199.9" "1322.5" "1119.7" "1227.9" "1663.1" "1384.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-109273256828227415" "False" "High" "IsMasterProtein" "Q07866" "Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2" "0.000" "False" "158.223" "39" "24" "50" "18" "573" "65.3" "6.20" "173.05" "24" "cell adhesion;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00515, Pf13374, Pf13424" "3831" "ENSG00000126214" "KLC1" "A6NF62; F8VTM4; hsa:3831; Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; IL-18 signaling pathway; Alzheimer's disease" "8" "3" "0.973" "0.976" "0.965" "0.980" "1.014" "0.951" "0.959" "0.996" "0.973" "4640.5" "4513.0" "4527.8" "4476.4" "4549.8" "4705.6" "4412.6" "4449.7" "4623.0" "4516.0" "" "" "" "" "" "" "" "" "" "" "3727.2" "3256.5" "3596.6" "2999.2" "3146.7" "3530.5" "3089.5" "3249.6" "4623.0" "3672.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868363632382073498" "False" "High" "IsMasterProtein" "Q6UB35" "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" "0.000" "False" "158.203" "27" "22" "33" "21" "978" "105.7" "8.06" "117.64" "22" "other metabolic processes;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "25902" "ENSG00000120254" "MTHFD1L" "hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8" "Metabolism of folate and pterines" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "3" "0" "1.011" "1.002" "0.954" "0.958" "0.964" "0.901" "0.960" "0.966" "0.951" "3040.7" "3075.2" "3045.6" "2901.4" "2912.4" "2930.0" "2739.3" "2919.5" "2937.6" "2892.7" "" "" "" "" "" "" "" "" "" "" "2442.3" "2219.0" "2419.3" "1943.9" "2014.2" "2198.3" "1917.9" "2132.1" "2937.6" "2352.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6965600281876429507" "False" "High" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "0.000" "False" "157.779" "45" "22" "58" "21" "649" "73.4" "7.88" "202.95" "22" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; P46063" "" "Progeria-associated lipodystrophy" "1" "1" "1.007" "1.026" "0.967" "0.955" "1.024" "0.959" "0.985" "1.002" "0.993" "6634.4" "6677.7" "6805.3" "6414.0" "6338.8" "6793.7" "6364.5" "6536.1" "6644.8" "6588.8" "" "" "" "" "" "" "" "" "" "" "5328.6" "4818.5" "5405.7" "4297.4" "4384.0" "5097.2" "4456.1" "4773.3" "6644.8" "5358.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951923410761951319" "False" "High" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "0.000" "False" "157.384" "51" "19" "113" "18" "394" "43.8" "6.55" "333.86" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "Neutrophil degranulation" "" "1" "0" "0.966" "0.993" "1.028" "1.043" "1.043" "1.082" "1.036" "1.009" "1.012" "9045.7" "8738.1" "8979.8" "9295.4" "9434.0" "9439.1" "9789.7" "9367.2" "9124.8" "9152.6" "" "" "" "" "" "" "" "" "" "" "7265.4" "6305.2" "7133.0" "6227.9" "6524.6" "7082.0" "6854.2" "6840.9" "9124.8" "7443.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8980263924004467581" "False" "High" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "0.000" "False" "156.916" "28" "26" "39" "25" "1107" "123.6" "7.03" "136.76" "26" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "27" "0" "1.042" "1.005" "1.046" "1.074" "1.021" "0.942" "1.012" "1.024" "1.007" "2968.0" "3092.7" "2983.0" "3104.2" "3188.2" "3031.8" "2794.6" "3003.9" "3040.7" "2989.0" "" "" "" "" "" "" "" "" "" "" "2383.8" "2231.6" "2369.5" "2079.8" "2205.0" "2274.7" "1956.6" "2193.8" "3040.7" "2430.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1529174177095472519" "False" "High" "IsMasterProtein" "O14777" "Kinetochore protein NDC80 homolog OS=Homo sapiens OX=9606 GN=NDC80 PE=1 SV=1" "0.000" "False" "156.715" "43" "27" "49" "27" "642" "73.9" "5.60" "170.32" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03801, Pf18077" "10403" "ENSG00000080986" "NDC80" "hsa:10403; O14777; Q6PJX2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.996" "1.012" "0.938" "0.966" "0.984" "0.893" "0.914" "0.964" "0.970" "5636.7" "5613.8" "5705.9" "5287.8" "5444.6" "5546.7" "5033.6" "5150.3" "5433.0" "5466.9" "" "" "" "" "" "" "" "" "" "" "4527.3" "4050.8" "4532.4" "3542.8" "3765.5" "4161.6" "3524.3" "3761.2" "5433.0" "4445.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5836622772794954890" "False" "High" "IsMasterProtein" "P06400" "Retinoblastoma-associated protein OS=Homo sapiens OX=9606 GN=RB1 PE=1 SV=2" "0.000" "False" "156.213" "28" "27" "58" "27" "928" "106.1" "7.94" "177.67" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5925" "ENSG00000139687" "RB1" "A8K5E3; hsa:5925; P06400; P78499; Q5VW46; Q8IZL4" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Aberrant regulation of mitotic exit in cancer due to RB1 defects; RUNX2 regulates osteoblast differentiation; Condensation of Prophase Chromosomes; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Cyclin A:Cdk2-associated events at S phase entry; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Inhibition of replication initiation of damaged DNA by RB1/E2F1; Defective translocation of RB1 mutants to the nucleus; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; Nuclear events stimulated by ALK signaling in cancer" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Bladder cancer; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; Ciliary landscape; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sphingolipid metabolism in senescence; Prostaglandin and leukotriene metabolism in senescence ; ID signaling pathway; TROP2 regulatory signaling; Prostaglandin and leukotriene metabolism in senescence ; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; DNA damage response" "51" "0" "0.999" "1.005" "0.974" "0.972" "0.966" "0.926" "1.005" "1.003" "0.971" "5666.7" "5659.8" "5694.0" "5521.2" "5508.5" "5473.3" "5245.5" "5692.7" "5686.4" "5500.9" "" "" "" "" "" "" "" "" "" "" "4551.4" "4084.0" "4523.0" "3699.2" "3809.7" "4106.5" "3672.6" "4157.4" "5686.4" "4473.5" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088967002815659299" "False" "High" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "0.000" "False" "155.798" "42" "19" "53" "19" "437" "50.1" "6.67" "179.67" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "Translation factors" "3" "0" "1.001" "1.004" "0.998" "1.042" "0.982" "1.038" "0.992" "1.072" "1.006" "5552.0" "5557.3" "5576.8" "5541.0" "5784.7" "5450.7" "5764.3" "5509.3" "5950.6" "5583.3" "" "" "" "" "" "" "" "" "" "" "4459.3" "4010.0" "4429.9" "3712.5" "4000.8" "4089.6" "4035.9" "4023.4" "5950.6" "4540.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4780754661784181438" "False" "High" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "0.000" "False" "155.346" "23" "18" "38" "18" "1038" "119.4" "4.82" "133.44" "18" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "0" "0.996" "1.003" "0.956" "0.946" "0.961" "0.943" "0.975" "0.925" "0.967" "3219.6" "3207.0" "3230.2" "3079.4" "3046.8" "3094.6" "3035.1" "3139.3" "2976.7" "3112.9" "" "" "" "" "" "" "" "" "" "" "2586.0" "2314.1" "2565.9" "2063.2" "2107.2" "2321.8" "2125.1" "2292.7" "2976.7" "2531.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9022416781062355686" "False" "High" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "0.000" "False" "155.225" "16" "36" "43" "36" "2620" "294.2" "6.14" "134.30" "36" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf00443" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "Ub-specific processing proteases" "" "1" "0" "1.009" "0.993" "1.029" "1.034" "1.025" "0.956" "0.979" "0.945" "1.002" "3030.5" "3057.5" "3007.8" "3119.4" "3133.7" "3105.4" "2897.4" "2965.9" "2862.9" "3036.8" "" "" "" "" "" "" "" "" "" "" "2434.0" "2206.2" "2389.2" "2090.0" "2167.3" "2329.9" "2028.6" "2166.0" "2862.9" "2469.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7179197342339518209" "False" "High" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "0.000" "False" "155.159" "64" "11" "49" "9" "286" "32.9" "5.69" "204.70" "11" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "Sensory processing of sound by inner hair cells of the cochlea; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "" "8" "2" "0.966" "0.939" "0.997" "1.025" "0.978" "1.033" "1.006" "0.959" "0.997" "3760.2" "3631.9" "3532.0" "3747.9" "3852.9" "3676.9" "3885.9" "3783.5" "3605.3" "3748.3" "" "" "" "" "" "" "" "" "" "" "3020.2" "2620.6" "2805.6" "2511.1" "2664.7" "2758.7" "2720.7" "2763.1" "3605.3" "3048.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5310524526174993710" "False" "High" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "0.000" "False" "155.138" "36" "22" "37" "18" "745" "82.8" "7.37" "121.71" "22" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "4" "1.000" "1.024" "0.998" "1.016" "1.013" "1.014" "1.031" "0.982" "1.001" "2663.5" "2662.7" "2727.3" "2659.3" "2706.0" "2699.4" "2702.0" "2745.2" "2616.1" "2665.8" "" "" "" "" "" "" "" "" "" "" "2139.3" "1921.3" "2166.4" "1781.8" "1871.5" "2025.3" "1891.8" "2004.8" "2616.1" "2167.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1302469806401564563" "False" "High" "IsMasterProtein" "P49748" "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1" "0.000" "False" "155.107" "45" "22" "34" "22" "655" "70.3" "8.75" "134.74" "22" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "37" "ENSG00000072778" "ACADVL" "B4DEB6; F5H2A9; hsa:37; O76056; P49748; Q8WUL0" "XBP1(S) activates chaperone genes; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation" "4" "0" "0.990" "0.981" "1.010" "0.982" "0.959" "0.927" "0.923" "0.909" "0.976" "3589.5" "3552.4" "3520.2" "3627.2" "3523.6" "3442.1" "3327.8" "3314.2" "3263.0" "3501.6" "" "" "" "" "" "" "" "" "" "" "2883.0" "2563.3" "2796.2" "2430.2" "2437.0" "2582.5" "2329.9" "2420.4" "3263.0" "2847.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562361449972294003" "False" "High" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "0.000" "False" "154.605" "48" "25" "48" "25" "579" "63.7" "8.87" "162.66" "25" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "" "1" "0" "1.022" "1.023" "0.973" "0.972" "0.982" "0.928" "0.940" "0.962" "0.964" "4303.4" "4398.4" "4403.3" "4186.7" "4182.0" "4224.9" "3995.5" "4043.6" "4140.5" "4148.6" "" "" "" "" "" "" "" "" "" "" "3456.5" "3173.8" "3497.7" "2805.1" "2892.3" "3169.9" "2797.4" "2953.1" "4140.5" "3373.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1718244645714628913" "False" "High" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "0.000" "False" "154.450" "31" "29" "48" "29" "1087" "123.8" "6.32" "155.13" "29" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "0.995" "0.985" "0.972" "1.012" "0.998" "0.966" "0.938" "0.959" "0.983" "4081.8" "4063.0" "4018.7" "3968.2" "4129.2" "4075.5" "3942.0" "3827.5" "3916.2" "4014.0" "" "" "" "" "" "" "" "" "" "" "3278.4" "2931.7" "3192.2" "2658.7" "2855.8" "3057.7" "2760.0" "2795.2" "3916.2" "3264.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3779865839115366179" "False" "High" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "0.000" "False" "154.278" "46" "21" "54" "20" "558" "61.4" "7.80" "172.29" "21" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; Glutamate and glutamine metabolism" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation" "9" "0" "0.974" "0.975" "0.936" "0.957" "0.963" "0.924" "0.952" "0.905" "0.972" "5371.4" "5230.5" "5238.1" "5028.7" "5138.5" "5174.3" "4961.5" "5114.8" "4860.6" "5220.0" "" "" "" "" "" "" "" "" "" "" "4314.2" "3774.2" "4160.8" "3369.2" "3553.9" "3882.2" "3473.8" "3735.3" "4860.6" "4245.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6241342632728061571" "False" "High" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "0.000" "False" "154.201" "52" "22" "38" "22" "476" "54.8" "6.61" "142.99" "22" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "mRNA processing; 15q25 copy number variation" "5" "0" "0.993" "1.017" "0.979" "0.972" "0.971" "0.939" "1.003" "0.962" "0.978" "3615.9" "3592.2" "3676.6" "3540.4" "3515.6" "3511.3" "3394.0" "3627.7" "3478.1" "3538.1" "" "" "" "" "" "" "" "" "" "" "2904.2" "2592.0" "2920.5" "2372.0" "2431.4" "2634.5" "2376.3" "2649.4" "3478.1" "2877.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629883586476679929" "False" "High" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "0.000" "False" "154.088" "60" "20" "37" "20" "406" "46.2" "5.83" "147.49" "20" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle" "Ciliary landscape" "6" "0" "1.033" "0.997" "0.996" "1.004" "1.007" "0.976" "0.996" "0.977" "0.993" "4070.6" "4203.6" "4059.5" "4054.6" "4085.8" "4098.3" "3973.2" "4053.0" "3976.0" "4044.1" "" "" "" "" "" "" "" "" "" "" "3269.5" "3033.2" "3224.6" "2716.6" "2825.8" "3074.9" "2781.8" "2959.9" "3976.0" "3288.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6708028902102911891" "False" "High" "IsMasterProtein" "P21281" "V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3" "0.000" "False" "154.007" "50" "19" "47" "19" "511" "56.5" "5.81" "161.81" "19" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "526" "ENSG00000147416" "ATP6V1B2" "B2R5Z3; D3DSQ5; hsa:526; P21281; Q14544; Q15859; Q96IR0" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "" "5" "0" "1.006" "1.003" "0.997" "0.989" "1.000" "0.969" "1.003" "0.997" "1.028" "3242.4" "3261.2" "3253.5" "3231.8" "3205.6" "3243.4" "3141.6" "3252.4" "3233.4" "3331.8" "" "" "" "" "" "" "" "" "" "" "2604.3" "2353.2" "2584.4" "2165.3" "2217.0" "2433.4" "2199.6" "2375.2" "3233.4" "2709.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1983440514863483257" "False" "High" "IsMasterProtein" "O15523" "ATP-dependent RNA helicase DDX3Y OS=Homo sapiens OX=9606 GN=DDX3Y PE=1 SV=2" "0.000" "False" "153.722" "35" "23" "39" "4" "660" "73.1" "7.55" "134.40" "23" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "8653" "ENSG00000067048" "DDX3Y" "B4DK29; B4DXX7; hsa:8653; O15523; Q8IYV7" "" "Novel intracellular components of RIG-I-like receptor pathway" "1" "0" "0.863" "0.888" "1.092" "1.084" "0.932" "1.209" "1.035" "1.152" "1.024" "322.3" "278.3" "286.3" "351.8" "349.5" "300.4" "389.7" "333.7" "371.2" "329.9" "" "" "" "" "" "" "" "" "" "" "258.8" "200.8" "227.4" "235.7" "241.7" "225.4" "272.8" "243.7" "371.2" "268.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990763445808986334" "False" "High" "IsMasterProtein" "O75083" "WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4" "0.000" "False" "153.710" "36" "16" "52" "16" "606" "66.2" "6.65" "185.35" "16" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00400" "9948" "ENSG00000071127" "WDR1" "A8K6E9; A8MPU4; hsa:9948; O75083; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0" "Platelet degranulation" "Hypertrophy model" "2" "0" "0.959" "0.986" "0.919" "0.959" "0.982" "0.959" "0.952" "0.932" "0.953" "5440.0" "5216.5" "5362.9" "5000.9" "5216.0" "5341.6" "5214.7" "5176.8" "5068.3" "5184.3" "" "" "" "" "" "" "" "" "" "" "4369.4" "3764.0" "4259.9" "3350.6" "3607.4" "4007.7" "3651.1" "3780.6" "5068.3" "4216.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042042739323188079" "False" "High" "IsMasterProtein" "Q9UQ35" "Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2" "0.000" "False" "153.655" "13" "29" "39" "29" "2752" "299.4" "12.06" "128.41" "29" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08312" "23524" "ENSG00000167978" "SRRM2" "A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40" "mRNA Splicing - Major Pathway" "" "1" "0" "0.873" "0.905" "1.068" "1.056" "1.119" "1.264" "1.057" "1.146" "1.067" "2001.9" "1747.8" "1810.7" "2137.8" "2113.7" "2239.8" "2530.5" "2115.5" "2293.2" "2136.6" "" "" "" "" "" "" "" "" "" "" "1607.9" "1261.1" "1438.3" "1432.3" "1461.9" "1680.5" "1771.7" "1544.9" "2293.2" "1737.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2636434062481616227" "False" "High" "IsMasterProtein" "P42858" "Huntingtin OS=Homo sapiens OX=9606 GN=HTT PE=1 SV=2" "0.000" "False" "153.644" "12" "32" "38" "32" "3142" "347.4" "6.20" "134.79" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf20925, Pf20926, Pf20927" "3064" "ENSG00000197386" "HTT" "hsa:3064; P42858; Q9UQB7" "Regulation of MECP2 expression and activity" "Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome; 15q25 copy number variation; HDAC6 interactions in the central nervous system" "7" "0" "1.013" "0.992" "1.104" "1.045" "0.995" "1.029" "0.995" "0.992" "1.022" "2677.0" "2711.9" "2654.4" "2954.6" "2798.5" "2664.5" "2755.3" "2663.1" "2654.4" "2735.6" "" "" "" "" "" "" "" "" "" "" "2150.1" "1956.8" "2108.5" "1979.6" "1935.5" "1999.1" "1929.1" "1944.9" "2654.4" "2224.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8725302829576246174" "False" "High" "IsMasterProtein" "P63151" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1" "0.000" "False" "153.510" "43" "15" "28" "11" "447" "51.7" "6.20" "119.27" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "" "5520" "ENSG00000221914" "PPP2R2A" "B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "7" "4" "0.943" "0.957" "0.895" "0.949" "0.948" "0.941" "0.963" "0.918" "0.935" "2939.3" "2771.2" "2811.7" "2632.1" "2789.8" "2787.1" "2766.9" "2830.8" "2698.9" "2748.9" "" "" "" "" "" "" "" "" "" "" "2360.8" "1999.7" "2233.5" "1763.5" "1929.5" "2091.1" "1937.2" "2067.4" "2698.9" "2235.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4198310778640922638" "False" "High" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "0.000" "False" "153.285" "65" "17" "45" "17" "350" "38.4" "5.12" "174.36" "17" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "Downregulation of TGF-beta receptor signaling" "TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer" "3" "0" "0.981" "0.995" "0.949" "0.985" "0.999" "0.959" "0.969" "0.997" "0.973" "5985.9" "5870.8" "5957.5" "5678.5" "5894.8" "5982.5" "5743.3" "5800.2" "5966.4" "5827.0" "" "" "" "" "" "" "" "" "" "" "4807.8" "4236.2" "4732.2" "3804.6" "4076.9" "4488.6" "4021.2" "4235.9" "5966.4" "4738.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7460100142715479081" "False" "High" "IsMasterProtein" "P09960" "Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2" "0.000" "False" "153.281" "36" "18" "40" "18" "611" "69.2" "6.18" "147.33" "18" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf09127, Pf17900" "4048" "ENSG00000111144" "LTA4H" "B4DNQ9; F8VV40; hsa:4048; P09960; Q6IAT6; Q9UCT7" "Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins" "Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "12" "0" "0.960" "0.938" "0.948" "0.935" "0.961" "0.944" "0.905" "0.899" "0.945" "4128.5" "3962.8" "3872.9" "3912.9" "3861.8" "3969.5" "3899.0" "3737.6" "3711.1" "3902.2" "" "" "" "" "" "" "" "" "" "" "3316.0" "2859.4" "3076.4" "2621.6" "2670.8" "2978.2" "2729.9" "2729.6" "3711.1" "3173.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5264367170864335030" "False" "High" "IsMasterProtein" "Q96K76" "Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47 PE=1 SV=3" "0.000" "False" "153.100" "20" "24" "31" "23" "1375" "157.2" "5.08" "107.93" "24" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf19718" "55031" "ENSG00000170242" "USP47" "B3KXF5; E9PM46; hsa:55031; Q658U0; Q86Y73; Q8TEP6; Q96K76; Q9BWI0; Q9NWN1" "Ub-specific processing proteases" "" "1" "0" "1.005" "0.988" "1.041" "1.041" "0.998" "0.985" "1.046" "1.018" "1.002" "2451.9" "2465.4" "2421.4" "2553.5" "2553.6" "2447.6" "2414.2" "2565.4" "2495.9" "2456.7" "" "" "" "" "" "" "" "" "" "" "1969.4" "1779.0" "1923.4" "1710.8" "1766.1" "1836.4" "1690.3" "1873.5" "2495.9" "1997.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1675638052339020088" "False" "High" "IsMasterProtein" "O75146" "Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2" "0.000" "False" "152.489" "30" "31" "39" "31" "1068" "119.3" "6.67" "140.30" "31" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01608, Pf07651, Pf16515" "9026" "ENSG00000130787" "HIP1R" "A6NHQ6; hsa:9026; O75146; Q6NXG8; Q9UED9" "Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "5q35 copy number variation" "3" "0" "0.987" "0.992" "1.030" "0.991" "1.033" "1.048" "1.017" "1.050" "1.027" "2979.8" "2941.7" "2955.2" "3068.0" "2951.8" "3078.1" "3122.6" "3030.2" "3127.9" "3059.3" "" "" "" "" "" "" "" "" "" "" "2393.3" "2122.7" "2347.4" "2055.6" "2041.5" "2309.4" "2186.3" "2213.0" "3127.9" "2487.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4471349255838518587" "False" "High" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "0.000" "False" "152.473" "49" "22" "75" "20" "432" "47.7" "6.34" "243.43" "22" "other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications; Spina bifida" "11" "2" "0.997" "1.015" "0.983" "0.980" "0.990" "0.981" "0.934" "0.999" "0.972" "7573.2" "7549.8" "7688.5" "7447.7" "7424.0" "7497.3" "7432.6" "7071.7" "7566.6" "7359.8" "" "" "" "" "" "" "" "" "" "" "6082.7" "5447.7" "6107.2" "4989.9" "5134.5" "5625.1" "5203.9" "5164.5" "7566.6" "5985.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9125415552757105331" "False" "High" "IsMasterProtein" "Q05639" "Elongation factor 1-alpha 2 OS=Homo sapiens OX=9606 GN=EEF1A2 PE=1 SV=1" "0.000" "False" "152.080" "47" "19" "125" "8" "463" "50.4" "9.03" "375.96" "19" "protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "1917" "ENSG00000101210" "EEF1A2" "B5BUF3; E1P5J1; hsa:1917; P54266; Q05639; Q0VGC7" "Eukaryotic Translation Elongation" "Translation factors" "2" "0" "0.944" "1.020" "0.894" "0.945" "0.970" "0.923" "0.948" "1.016" "0.942" "3091.9" "2919.7" "3154.4" "2763.8" "2921.5" "2999.7" "2852.6" "2932.2" "3142.1" "2913.4" "" "" "" "" "" "" "" "" "" "" "2483.4" "2106.8" "2505.7" "1851.7" "2020.5" "2250.6" "1997.2" "2141.4" "3142.1" "2369.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8527092773428768711" "False" "High" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "0.000" "False" "152.056" "53" "17" "37" "17" "401" "44.2" "5.21" "151.00" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Vasopressin-regulated water reabsorption" "12" "0" "1.043" "1.045" "1.032" "0.967" "0.944" "1.028" "0.922" "1.012" "1.004" "2909.7" "3033.4" "3041.5" "3001.7" "2813.9" "2746.7" "2989.9" "2682.5" "2945.3" "2922.2" "" "" "" "" "" "" "" "" "" "" "2337.1" "2188.8" "2416.0" "2011.1" "1946.1" "2060.8" "2093.4" "1959.1" "2945.3" "2376.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5486623488286150829" "False" "High" "IsMasterProtein" "Q9UBT2" "SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2" "0.000" "False" "151.764" "41" "21" "46" "21" "640" "71.2" "5.29" "151.01" "21" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00899, Pf14732, Pf16195" "10054" "ENSG00000126261" "UBA2" "B3KWB9; hsa:10054; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UBT2; Q9UED2" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "" "2" "0" "0.984" "1.002" "0.997" "0.941" "0.953" "0.927" "0.952" "0.926" "0.949" "3754.9" "3696.2" "3761.1" "3744.6" "3534.0" "3579.1" "3482.3" "3574.2" "3475.7" "3562.9" "" "" "" "" "" "" "" "" "" "" "3015.9" "2667.1" "2987.5" "2508.9" "2444.1" "2685.3" "2438.1" "2610.2" "3475.7" "2897.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781846477469752128" "False" "High" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "0.000" "False" "151.652" "40" "21" "59" "21" "617" "68.3" "5.52" "191.02" "21" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "1.000" "1.021" "1.000" "0.972" "1.010" "0.964" "0.981" "1.015" "0.981" "4022.6" "4021.7" "4109.0" "4021.0" "3911.7" "4061.8" "3879.1" "3945.9" "4081.6" "3945.2" "" "" "" "" "" "" "" "" "" "" "3230.9" "2902.0" "3263.9" "2694.1" "2705.3" "3047.5" "2715.9" "2881.7" "4081.6" "3208.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7968684939462891772" "False" "High" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "0.000" "False" "151.621" "29" "28" "36" "28" "1030" "115.2" "5.40" "119.20" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "8" "0" "0.902" "0.958" "1.062" "1.007" "1.055" "1.186" "1.078" "1.094" "1.082" "2997.6" "2702.6" "2870.9" "3184.1" "3019.8" "3163.2" "3556.4" "3232.4" "3278.4" "3244.5" "" "" "" "" "" "" "" "" "" "" "2407.6" "1950.1" "2280.5" "2133.4" "2088.5" "2373.3" "2490.0" "2360.6" "3278.4" "2638.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5335677543697524354" "False" "High" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "0.000" "False" "151.593" "43" "26" "70" "19" "614" "69.1" "8.92" "198.63" "26" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; SUMOylation of transcription cofactors; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "Ciliary landscape" "6" "0" "0.983" "1.005" "1.031" "1.058" "1.044" "1.091" "1.085" "1.049" "1.060" "4510.7" "4433.9" "4534.6" "4648.7" "4773.6" "4711.1" "4922.7" "4893.9" "4732.1" "4779.6" "" "" "" "" "" "" "" "" "" "" "3623.0" "3199.4" "3602.0" "3114.6" "3301.5" "3534.6" "3446.6" "3574.0" "4732.1" "3887.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364177795992672609" "False" "High" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "0.000" "False" "151.555" "54" "16" "36" "16" "397" "41.9" "8.09" "150.15" "16" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Mitochondrial Fatty Acid Beta-Oxidation" "Fatty acid biosynthesis" "2" "0" "0.990" "0.971" "1.002" "0.971" "0.949" "1.013" "0.948" "0.925" "0.969" "2880.8" "2852.5" "2797.0" "2887.3" "2796.9" "2734.3" "2917.1" "2730.4" "2665.9" "2792.9" "" "" "" "" "" "" "" "" "" "" "2313.8" "2058.3" "2221.8" "1934.5" "1934.4" "2051.5" "2042.4" "1994.0" "2665.9" "2271.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531814392904203237" "False" "High" "IsMasterProtein" "P09884" "DNA polymerase alpha catalytic subunit OS=Homo sapiens OX=9606 GN=POLA1 PE=1 SV=2" "0.000" "False" "151.315" "19" "21" "34" "21" "1462" "165.8" "5.85" "116.22" "21" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08996, Pf12254" "5422" "ENSG00000101868" "POLA1" "hsa:5422; P09884; Q86UQ7" "Activation of the pre-replicative complex; Defective pyroptosis; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication" "13" "0" "0.933" "0.872" "0.838" "0.889" "0.934" "1.142" "0.992" "0.952" "0.938" "2809.2" "2621.5" "2450.0" "2355.2" "2497.1" "2623.6" "3208.0" "2786.6" "2675.0" "2635.8" "" "" "" "" "" "" "" "" "" "" "2256.4" "1891.6" "1946.1" "1578.0" "1727.0" "1968.4" "2246.1" "2035.0" "2675.0" "2143.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877327812570757942" "False" "High" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "0.000" "False" "151.074" "34" "29" "50" "29" "870" "98.0" "7.44" "166.49" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "Clathrin-mediated endocytosis; Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; NGF-stimulated transcription; Golgi Associated Vesicle Biogenesis; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "14" "0" "1.007" "0.983" "1.003" "0.987" "0.968" "0.956" "1.013" "0.968" "0.990" "3503.9" "3529.4" "3444.6" "3514.0" "3458.3" "3393.0" "3351.2" "3548.0" "3391.8" "3469.9" "" "" "" "" "" "" "" "" "" "" "2814.3" "2546.7" "2736.1" "2354.4" "2391.8" "2545.7" "2346.3" "2591.1" "3391.8" "2821.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200124319077870265" "False" "High" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "0.000" "False" "151.040" "50" "20" "48" "20" "433" "48.6" "5.95" "158.09" "20" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862, Pf21236" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.008" "0.995" "1.005" "1.001" "0.963" "0.998" "1.009" "0.994" "0.975" "3788.7" "3820.7" "3770.1" "3808.2" "3791.0" "3649.0" "3780.7" "3821.5" "3765.5" "3695.0" "" "" "" "" "" "" "" "" "" "" "3043.1" "2756.9" "2994.7" "2551.5" "2621.9" "2737.8" "2647.1" "2790.9" "3765.5" "3004.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437686464987713845" "False" "High" "IsMasterProtein" "Q9BUF5" "Tubulin beta-6 chain OS=Homo sapiens OX=9606 GN=TUBB6 PE=1 SV=1" "0.000" "False" "150.783" "48" "16" "114" "7" "446" "49.8" "4.88" "295.53" "16" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84617" "ENSG00000176014" "TUBB6" "B3KM76; hsa:84617; Q9BUF5; Q9HA42" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Prefoldin mediated transfer of substrate to CCT/TriC; MHC class II antigen presentation; Assembly and cell surface presentation of NMDA receptors; Sealing of the nuclear envelope (NE) by ESCRT-III; Post-chaperonin tubulin folding pathway; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Activation of AMPK downstream of NMDARs; Aggrephagy; Kinesins; PKR-mediated signaling; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "35" "0" "0.988" "0.987" "0.944" "0.967" "1.019" "0.909" "0.995" "0.998" "0.994" "1678.4" "1658.2" "1657.0" "1584.3" "1623.7" "1710.6" "1525.3" "1670.4" "1675.6" "1667.9" "" "" "" "" "" "" "" "" "" "" "1348.1" "1196.5" "1316.2" "1061.5" "1123.0" "1283.4" "1067.9" "1219.9" "1675.6" "1356.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6019619507196981202" "False" "High" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "0.000" "False" "150.691" "51" "17" "51" "14" "418" "47.3" "5.88" "170.88" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "FCGR3A-mediated phagocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Physico-chemical features and toxicity-associated pathways" "6" "3" "0.981" "1.005" "0.971" "0.985" "0.993" "0.947" "0.958" "0.971" "0.976" "5618.0" "5510.6" "5645.5" "5452.8" "5534.5" "5580.4" "5322.7" "5381.9" "5457.0" "5482.0" "" "" "" "" "" "" "" "" "" "" "4512.3" "3976.3" "4484.4" "3653.4" "3827.7" "4186.9" "3726.7" "3930.5" "5457.0" "4458.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1882334441137329574" "False" "High" "IsMasterProtein" "Q9BUJ2" "Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2" "0.000" "False" "150.283" "30" "19" "39" "19" "856" "95.7" "6.92" "141.82" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf02037, Pf13671" "11100" "ENSG00000105323" "HNRNPUL1" "B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75" "" "" "0" "0" "1.024" "1.046" "0.990" "1.015" "1.041" "0.977" "0.981" "1.068" "1.050" "2638.9" "2702.1" "2761.5" "2611.6" "2677.5" "2746.7" "2578.7" "2589.3" "2817.6" "2770.6" "" "" "" "" "" "" "" "" "" "" "2119.6" "1949.8" "2193.5" "1749.8" "1851.8" "2060.8" "1805.5" "1891.0" "2817.6" "2253.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463755477932393031" "False" "High" "IsMasterProtein" "Q9H4M9" "EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2" "0.000" "False" "149.944" "37" "17" "43" "17" "534" "60.6" "6.83" "155.75" "17" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "10938" "ENSG00000110047" "EHD1" "hsa:10938; O14611; Q2M3Q4; Q9H4M9; Q9UNR3" "Factors involved in megakaryocyte development and platelet production" "Insulin signaling" "2" "0" "1.007" "0.982" "0.988" "1.000" "0.958" "0.998" "1.060" "1.045" "0.977" "3489.3" "3515.2" "3427.2" "3447.3" "3489.1" "3341.4" "3483.5" "3698.5" "3645.8" "3408.4" "" "" "" "" "" "" "" "" "" "" "2802.6" "2536.5" "2722.3" "2309.7" "2413.1" "2507.0" "2439.0" "2701.0" "3645.8" "2771.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2644989191906863874" "False" "High" "IsMasterProtein" "Q6ZSZ5" "Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4" "0.000" "False" "149.876" "22" "24" "33" "23" "1361" "151.5" "6.33" "126.13" "24" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00621, Pf17838" "23370" "ENSG00000104880" "ARHGEF18" "A8MV62; B5ME81; hsa:23370; I3L1I5; O60274; Q6DD92; Q6ZSZ5" "RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "" "5" "0" "1.007" "0.995" "0.970" "0.997" "0.930" "0.913" "1.015" "0.977" "0.969" "1622.6" "1634.3" "1614.2" "1574.6" "1618.1" "1509.1" "1480.7" "1646.1" "1585.6" "1571.9" "" "" "" "" "" "" "" "" "" "" "1303.2" "1179.2" "1282.2" "1055.0" "1119.1" "1132.3" "1036.7" "1202.2" "1585.6" "1278.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589685267009723312" "False" "High" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "0.000" "False" "149.492" "28" "21" "40" "21" "950" "108.5" "7.47" "136.99" "21" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "Association of TriC/CCT with target proteins during biosynthesis; Major pathway of rRNA processing in the nucleolus and cytosol" "mRNA processing" "3" "0" "1.015" "0.995" "1.006" "1.034" "0.961" "0.980" "1.017" "1.025" "1.024" "2418.2" "2454.8" "2405.8" "2433.1" "2500.8" "2323.3" "2369.4" "2459.2" "2478.6" "2475.9" "" "" "" "" "" "" "" "" "" "" "1942.2" "1771.3" "1911.0" "1630.2" "1729.6" "1743.1" "1658.9" "1796.0" "2478.6" "2013.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737848688669361571" "False" "High" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "0.000" "False" "149.333" "53" "15" "27" "15" "370" "40.5" "5.10" "116.72" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "RHOH GTPase cycle" "Alstrom syndrome" "2" "0" "0.997" "1.005" "1.019" "0.985" "0.995" "0.962" "1.047" "1.053" "1.030" "2031.0" "2025.4" "2041.4" "2069.6" "2001.2" "2021.4" "1953.2" "2126.8" "2138.1" "2091.8" "" "" "" "" "" "" "" "" "" "" "1631.3" "1461.5" "1621.5" "1386.6" "1384.0" "1516.6" "1367.5" "1553.2" "2138.1" "1701.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009427819375188157" "False" "High" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "0.000" "False" "149.166" "53" "15" "47" "15" "389" "44.1" "7.49" "169.49" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "MAPK6/MAPK4 signaling; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "0.993" "0.989" "0.948" "0.955" "0.955" "0.938" "0.936" "0.946" "0.964" "3191.8" "3170.3" "3155.6" "3026.6" "3047.6" "3048.4" "2995.0" "2986.8" "3018.3" "3078.4" "" "" "" "" "" "" "" "" "" "" "2563.6" "2287.6" "2506.6" "2027.8" "2107.8" "2287.2" "2096.9" "2181.2" "3018.3" "2503.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1724337932377857957" "False" "High" "IsMasterProtein" "Q13619" "Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3" "0.000" "False" "148.877" "38" "30" "48" "22" "759" "87.6" "8.13" "151.40" "30" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8451" "ENSG00000139842" "CUL4A" "A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17" "Formation of Incision Complex in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "7" "0.984" "1.027" "0.987" "0.952" "0.969" "0.932" "0.956" "0.927" "0.976" "4362.1" "4293.6" "4481.9" "4306.0" "4152.4" "4225.1" "4065.4" "4168.4" "4043.0" "4256.9" "" "" "" "" "" "" "" "" "" "" "3503.6" "3098.1" "3560.1" "2885.0" "2871.9" "3170.0" "2846.4" "3044.2" "4043.0" "3461.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904029165854268952" "False" "High" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "0.000" "False" "148.790" "55" "21" "53" "21" "440" "49.2" "6.21" "176.98" "21" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.025" "0.988" "1.014" "0.993" "0.966" "0.991" "0.982" "0.974" "0.986" "3920.0" "4016.6" "3873.6" "3973.3" "3892.1" "3785.6" "3886.3" "3850.5" "3819.5" "3863.4" "" "" "" "" "" "" "" "" "" "" "3148.5" "2898.3" "3076.9" "2662.1" "2691.8" "2840.3" "2721.0" "2812.0" "3819.5" "3141.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8833094404749326966" "False" "High" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "0.000" "False" "148.495" "40" "18" "48" "18" "508" "57.5" "7.80" "149.04" "18" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "Cytosolic tRNA aminoacylation" "" "1" "0" "0.975" "1.026" "0.990" "0.997" "0.989" "0.939" "0.946" "1.009" "1.001" "2184.9" "2130.3" "2241.3" "2162.5" "2179.2" "2160.8" "2052.3" "2067.9" "2204.8" "2186.7" "" "" "" "" "" "" "" "" "" "" "1754.9" "1537.1" "1780.3" "1448.9" "1507.2" "1621.2" "1436.9" "1510.2" "2204.8" "1778.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1799847195195984928" "False" "High" "IsMasterProtein" "Q5VYK3" "Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2" "0.000" "False" "148.474" "18" "27" "32" "27" "1845" "204.2" "7.12" "115.16" "27" "cell organization and biogenesis" "cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12755, Pf13001" "23392" "ENSG00000136813" "ECPAS" "A0A804HJA4; B3KXF2; O15074; Q5VYK3; Q8WU82" "" "" "0" "0" "0.965" "0.991" "1.017" "1.047" "1.008" "1.044" "1.019" "1.002" "1.046" "2133.2" "2058.8" "2114.9" "2169.4" "2233.9" "2149.6" "2226.6" "2172.9" "2137.8" "2231.8" "" "" "" "" "" "" "" "" "" "" "1713.4" "1485.5" "1679.9" "1453.5" "1545.0" "1612.8" "1559.0" "1586.9" "2137.8" "1815.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7233412111740596343" "False" "High" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "0.000" "False" "148.466" "32" "27" "40" "25" "917" "102.4" "6.80" "140.37" "27" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "12" "0" "0.980" "1.028" "0.978" "1.049" "1.057" "1.073" "1.022" "1.024" "1.023" "3886.3" "3809.3" "3994.3" "3800.3" "4075.2" "4106.3" "4169.6" "3973.5" "3980.2" "3976.3" "" "" "" "" "" "" "" "" "" "" "3121.5" "2748.7" "3172.8" "2546.2" "2818.4" "3080.9" "2919.3" "2901.8" "3980.2" "3233.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586713697824146806" "False" "High" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "0.000" "False" "148.189" "23" "22" "36" "22" "1132" "119.3" "5.60" "140.25" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057, Pf20960" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "1.025" "1.010" "1.024" "1.019" "1.005" "0.947" "1.016" "1.028" "1.015" "3304.6" "3388.7" "3338.3" "3384.7" "3366.1" "3319.5" "3131.0" "3357.8" "3397.5" "3352.6" "" "" "" "" "" "" "" "" "" "" "2654.2" "2445.2" "2651.7" "2267.8" "2328.0" "2490.6" "2192.1" "2452.2" "3397.5" "2726.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2706346813500612186" "False" "High" "IsMasterProtein" "Q9C0C9" "(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3" "0.000" "False" "148.138" "25" "26" "47" "26" "1292" "141.2" "5.12" "150.66" "26" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "63893" "ENSG00000175931" "UBE2O" "A6NDU5; hsa:63893; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9C0C9; Q9H6E6; Q9H7E4; Q9H9B2" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.996" "1.015" "1.024" "1.030" "1.010" "1.024" "0.985" "1.022" "1.020" "2167.6" "2158.4" "2200.1" "2220.0" "2233.2" "2189.8" "2220.3" "2136.0" "2216.0" "2210.6" "" "" "" "" "" "" "" "" "" "" "1741.0" "1557.5" "1747.6" "1487.4" "1544.5" "1643.0" "1554.6" "1560.0" "2216.0" "1797.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588526575422441763" "False" "High" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "0.000" "False" "148.011" "30" "29" "46" "29" "1042" "117.7" "6.52" "155.88" "29" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf21408" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "1.005" "1.013" "1.009" "1.012" "1.009" "1.008" "1.027" "1.017" "1.017" "4654.2" "4678.3" "4715.8" "4695.3" "4709.2" "4697.9" "4693.7" "4779.2" "4733.1" "4732.4" "" "" "" "" "" "" "" "" "" "" "3738.2" "3375.7" "3745.9" "3145.8" "3256.9" "3524.7" "3286.3" "3490.3" "4733.1" "3848.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1873273852874603797" "False" "High" "IsMasterProtein" "Q709C8" "Intermembrane lipid transfer protein VPS13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1" "0.000" "False" "147.707" "9" "28" "30" "28" "3753" "422.1" "6.83" "100.92" "28" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "54832" "ENSG00000129003" "VPS13C" "hsa:54832; Q6ISR4; Q702P2; Q702P3; Q709C8; Q709C9; Q9NXN8; Q9P2C6" "" "" "0" "0" "1.022" "1.003" "1.047" "1.050" "0.948" "0.969" "0.971" "0.985" "1.032" "1621.5" "1657.6" "1626.6" "1697.8" "1702.1" "1537.8" "1571.6" "1575.1" "1596.5" "1673.8" "" "" "" "" "" "" "" "" "" "" "1302.4" "1196.1" "1292.1" "1137.5" "1177.2" "1153.8" "1100.3" "1150.3" "1596.5" "1361.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936479494832144237" "False" "High" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "0.000" "False" "147.235" "40" "26" "49" "26" "783" "85.9" "7.77" "157.92" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "Mitochondrial RNA degradation" "Pyrimidine metabolism; miRNA degrading enzymes" "3" "0" "1.004" "1.001" "0.990" "0.995" "0.965" "0.942" "0.973" "0.976" "0.993" "4332.9" "4350.0" "4337.3" "4289.4" "4310.6" "4181.8" "4079.8" "4215.6" "4228.3" "4301.3" "" "" "" "" "" "" "" "" "" "" "3480.2" "3138.8" "3445.3" "2873.9" "2981.2" "3137.5" "2856.5" "3078.7" "4228.3" "3497.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583580330514197896" "False" "High" "IsMasterProtein" "P55809" "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1" "0.000" "False" "147.231" "44" "17" "45" "17" "520" "56.1" "7.46" "146.48" "17" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01144" "5019" "ENSG00000083720" "OXCT1" "B2R5V2; B7Z528; hsa:5019; P55809" "Mitochondrial protein degradation; Utilization of Ketone Bodies" "" "2" "0" "1.005" "0.999" "0.968" "0.977" "0.995" "0.999" "0.985" "0.979" "0.995" "3243.2" "3260.4" "3238.9" "3139.6" "3167.3" "3227.9" "3239.9" "3194.9" "3175.9" "3225.5" "" "" "" "" "" "" "" "" "" "" "2604.9" "2352.6" "2572.8" "2103.5" "2190.5" "2421.8" "2268.4" "2333.3" "3175.9" "2623.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5568233219206595783" "False" "High" "IsMasterProtein" "Q9ULT8" "E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4" "0.000" "False" "147.093" "13" "30" "38" "30" "2610" "289.2" "5.35" "122.31" "30" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf00632, Pf06701, Pf07738, Pf12796, Pf18410" "25831" "ENSG00000092148" "HECTD1" "D3DS86; hsa:25831; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; Q9ULT8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.997" "1.038" "1.022" "1.017" "0.972" "0.998" "1.014" "1.025" "1.000" "2292.9" "2284.9" "2379.3" "2342.7" "2331.9" "2229.6" "2287.7" "2325.7" "2350.6" "2293.0" "" "" "" "" "" "" "" "" "" "" "1841.6" "1648.7" "1889.9" "1569.6" "1612.8" "1672.8" "1601.7" "1698.4" "2350.6" "1864.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8760607610450426056" "False" "High" "IsMasterProtein" "P35251" "Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4" "0.000" "False" "147.045" "20" "20" "32" "20" "1148" "128.2" "9.36" "115.15" "20" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf00533, Pf08519" "5981" "ENSG00000035928" "RFC1" "A8K6E7; hsa:5981; P35251; Q5XKF5; Q6PKU0; Q86V41; Q86V46" "PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "miRNA regulation of DNA damage response; DNA replication; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "22" "0" "1.076" "1.055" "1.085" "1.012" "0.969" "0.971" "1.184" "1.082" "1.063" "2952.7" "3176.0" "3116.4" "3204.7" "2988.7" "2861.5" "2868.2" "3494.6" "3194.8" "3138.2" "" "" "" "" "" "" "" "" "" "" "2371.6" "2291.7" "2475.5" "2147.1" "2067.0" "2146.9" "2008.2" "2552.2" "3194.8" "2552.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575182119282234217" "False" "High" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "0.000" "False" "147.037" "67" "13" "92" "13" "254" "28.8" "7.18" "300.26" "13" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "8" "0" "1.000" "1.015" "0.967" "1.053" "1.046" "1.006" "1.037" "1.033" "1.048" "5298.5" "5297.8" "5375.8" "5125.5" "5581.8" "5541.7" "5328.0" "5495.0" "5470.8" "5553.3" "" "" "" "" "" "" "" "" "" "" "4255.7" "3822.8" "4270.2" "3434.1" "3860.5" "4157.8" "3730.4" "4013.0" "5470.8" "4516.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312610725791659305" "False" "High" "IsMasterProtein" "P17812" "CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2" "0.000" "False" "146.997" "40" "22" "33" "20" "591" "66.6" "6.46" "128.74" "22" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "1503" "ENSG00000171793" "CTPS1" "B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "1" "1.005" "1.026" "0.959" "1.011" "1.006" "0.960" "1.014" "0.981" "0.988" "3525.3" "3544.0" "3617.2" "3381.1" "3563.9" "3547.1" "3385.9" "3576.2" "3458.1" "3484.0" "" "" "" "" "" "" "" "" "" "" "2831.5" "2557.3" "2873.3" "2265.3" "2464.8" "2661.3" "2370.6" "2611.7" "3458.1" "2833.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3504989653461023373" "False" "High" "IsMasterProtein" "P51570" "Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1" "0.000" "False" "146.874" "41" "15" "38" "15" "392" "42.2" "6.46" "166.97" "15" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2584" "ENSG00000108479" "GALK1" "B2RC07; B4E1G6; hsa:2584; P51570" "Galactose catabolism; Defective GALK1 causes GALCT2" "Disorders of galactose metabolism" "3" "0" "1.063" "1.024" "1.067" "1.083" "1.039" "1.120" "1.040" "1.035" "1.063" "2534.4" "2695.2" "2595.4" "2703.6" "2745.4" "2633.8" "2839.2" "2636.9" "2622.4" "2693.8" "" "" "" "" "" "" "" "" "" "" "2035.6" "1944.8" "2061.6" "1811.4" "1898.7" "1976.1" "1987.9" "1925.7" "2622.4" "2190.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3985188646102169391" "False" "High" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "0.000" "False" "146.868" "42" "16" "36" "16" "499" "56.8" "6.28" "135.06" "16" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "MAPK signaling pathway; ATM signaling in development and disease" "5" "0" "1.043" "0.981" "0.975" "0.927" "1.001" "0.863" "0.887" "1.007" "0.965" "4022.6" "4195.9" "3945.6" "3920.8" "3728.4" "4025.4" "3472.6" "3568.9" "4051.0" "3882.5" "" "" "" "" "" "" "" "" "" "" "3230.9" "3027.6" "3134.1" "2627.0" "2578.6" "3020.2" "2431.3" "2606.4" "4051.0" "3157.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9124965961007810906" "False" "High" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "0.000" "False" "146.602" "37" "29" "57" "29" "765" "90.7" "9.31" "173.73" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "SUMOylation of DNA replication proteins" "Ebola virus infection in host; 15q25 copy number variation" "3" "0" "0.993" "1.069" "1.021" "1.069" "1.076" "1.086" "1.008" "1.028" "1.056" "4652.1" "4619.4" "4971.0" "4747.6" "4972.0" "5003.6" "5050.4" "4689.4" "4781.9" "4913.5" "" "" "" "" "" "" "" "" "" "" "3736.5" "3333.2" "3948.7" "3180.9" "3438.7" "3754.1" "3536.1" "3424.7" "4781.9" "3995.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4685450292699183556" "False" "High" "IsMasterProtein" "P43246" "DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1" "0.000" "False" "146.304" "27" "23" "44" "23" "934" "104.7" "5.77" "148.75" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" "4436" "ENSG00000095002" "MSH2" "B4E2Z2; hsa:4436; O75488; P43246" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "12" "0" "0.980" "0.984" "0.954" "0.925" "0.912" "0.949" "1.012" "1.001" "0.973" "5055.9" "4955.3" "4975.2" "4822.2" "4679.1" "4610.1" "4797.4" "5114.8" "5061.5" "4918.7" "" "" "" "" "" "" "" "" "" "" "4060.8" "3575.6" "3952.0" "3230.9" "3236.1" "3458.9" "3358.9" "3735.4" "5061.5" "4000.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6148920523022948324" "False" "High" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "0.000" "False" "146.300" "30" "25" "45" "25" "906" "102.4" "5.27" "139.27" "25" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.051" "1.035" "1.075" "1.009" "1.006" "0.956" "1.031" "1.000" "1.016" "2543.9" "2672.8" "2633.8" "2733.8" "2566.2" "2558.7" "2432.6" "2621.7" "2542.8" "2583.6" "" "" "" "" "" "" "" "" "" "" "2043.3" "1928.6" "2092.1" "1831.6" "1774.8" "1919.7" "1703.2" "1914.6" "2542.8" "2101.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2586862151232699530" "False" "High" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "0.000" "False" "146.012" "42" "24" "51" "24" "508" "57.1" "4.87" "159.46" "24" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; VLDL assembly; LDL remodeling; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "13" "0" "0.968" "0.965" "0.952" "1.004" "0.980" "1.026" "1.059" "1.075" "0.989" "5704.2" "5519.3" "5505.2" "5428.1" "5725.5" "5590.2" "5851.4" "6039.6" "6130.2" "5639.7" "" "" "" "" "" "" "" "" "" "" "4581.6" "3982.6" "4373.0" "3636.9" "3959.8" "4194.2" "4096.8" "4410.7" "6130.2" "4586.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "376281410555249272" "False" "High" "IsMasterProtein" "O75592" "E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4" "0.000" "False" "145.849" "9" "42" "46" "42" "4678" "513.3" "7.02" "128.11" "42" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf03256, Pf08005, Pf13540" "23077" "ENSG00000005810" "MYCBP2" "A6NJC6; O75592; Q5JSX8; Q5VZN6; Q6PIB6; Q9UQ11; Q9Y6E4" "" "3q29 copy number variation syndrome" "1" "0" "1.053" "1.065" "1.049" "1.087" "1.010" "1.017" "1.086" "1.120" "1.081" "2659.2" "2801.0" "2831.7" "2790.0" "2890.6" "2684.9" "2703.7" "2887.9" "2978.4" "2874.9" "" "" "" "" "" "" "" "" "" "" "2135.8" "2021.1" "2249.3" "1869.3" "1999.2" "2014.5" "1893.0" "2109.0" "2978.4" "2338.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317219429199659424" "False" "High" "IsMasterProtein" "Q9H6Z4" "Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1" "0.000" "False" "145.665" "37" "18" "35" "18" "567" "60.2" "4.78" "136.77" "18" "transport" "nucleus;other cell component" "other molecular function" "Pf00638" "8498" "ENSG00000031823" "RANBP3" "B2RAT8; hsa:8498; O60405; O75759; O75760; Q9BT47; Q9H6Z4; Q9UG74" "" "" "0" "0" "1.024" "1.052" "1.006" "1.037" "1.000" "0.973" "0.986" "1.018" "1.019" "3262.8" "3340.9" "3432.7" "3283.2" "3382.2" "3263.5" "3175.1" "3216.7" "3321.4" "3323.9" "" "" "" "" "" "" "" "" "" "" "2620.7" "2410.7" "2726.7" "2199.7" "2339.2" "2448.5" "2223.0" "2349.2" "3321.4" "2703.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1721823371863977969" "False" "High" "IsMasterProtein" "Q92973" "Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2" "0.000" "False" "145.360" "26" "19" "42" "15" "898" "102.3" "4.98" "145.48" "19" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "3842" "ENSG00000083312" "TNPO1" "B4DVC6; hsa:3842; Q92957; Q92973; Q92975" "Postmitotic nuclear pore complex (NPC) reformation; Intraflagellar transport; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" "22q11.2 copy number variation syndrome" "4" "2" "1.005" "0.963" "0.965" "1.015" "0.962" "0.958" "0.975" "0.982" "1.001" "2515.6" "2527.8" "2422.2" "2428.2" "2553.8" "2420.3" "2410.5" "2454.0" "2471.2" "2517.4" "" "" "" "" "" "" "" "" "" "" "2020.5" "1824.0" "1924.0" "1626.9" "1766.2" "1815.9" "1687.7" "1792.1" "2471.2" "2047.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462391840116260305" "False" "High" "IsMasterProtein" "Q05086" "Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4" "0.000" "False" "144.779" "29" "22" "34" "22" "875" "100.6" "5.22" "110.06" "22" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00632, Pf16558" "7337" "ENSG00000114062" "UBE3A" "A8K8Z9; hsa:7337; P78355; Q05086; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9" "Antigen processing: Ubiquitination & Proteasome degradation" "Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder" "5" "0" "1.011" "0.997" "1.006" "1.050" "1.002" "0.999" "1.051" "1.014" "1.037" "2319.7" "2344.4" "2312.6" "2333.2" "2435.1" "2324.3" "2316.8" "2438.7" "2351.8" "2405.8" "" "" "" "" "" "" "" "" "" "" "1863.1" "1691.7" "1837.0" "1563.2" "1684.2" "1743.9" "1622.1" "1781.0" "2351.8" "1956.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3038689840563559267" "False" "High" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "0.000" "False" "144.486" "26" "26" "47" "25" "1075" "113.3" "8.59" "158.08" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "" "16p11.2 distal deletion syndrome" "1" "1" "0.981" "0.990" "0.975" "0.970" "0.979" "1.005" "0.993" "0.993" "0.973" "5011.6" "4916.3" "4963.6" "4886.3" "4859.9" "4904.9" "5038.3" "4976.4" "4976.8" "4875.3" "" "" "" "" "" "" "" "" "" "" "4025.3" "3547.4" "3942.8" "3273.8" "3361.2" "3680.1" "3527.6" "3634.3" "4976.8" "3964.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2531564844693564972" "False" "High" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "0.000" "False" "144.353" "42" "21" "42" "20" "530" "60.1" "9.13" "141.00" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "Vpr-mediated nuclear import of PICs; Formation of WDR5-containing histone-modifying complexes; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "MECP2 and associated Rett syndrome" "8" "1" "1.047" "1.032" "1.043" "1.041" "1.005" "1.031" "1.028" "1.048" "1.003" "4140.0" "4336.1" "4271.9" "4320.0" "4308.9" "4160.1" "4268.3" "4256.0" "4338.1" "4151.0" "" "" "" "" "" "" "" "" "" "" "3325.2" "3128.8" "3393.3" "2894.4" "2980.1" "3121.3" "2988.4" "3108.2" "4338.1" "3375.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176127761844367310" "False" "High" "IsMasterProtein" "Q9H2G2" "STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1" "0.000" "False" "144.344" "25" "27" "37" "25" "1235" "142.6" "5.15" "124.65" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "9748" "ENSG00000065613" "SLK" "D3DRA0; D3DRA1; hsa:9748; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9H2G2; Q9NQL0; Q9NQL1" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "TAR syndrome" "4" "1" "0.999" "0.968" "1.046" "1.024" "0.997" "1.090" "1.058" "1.092" "1.043" "2689.8" "2686.8" "2604.0" "2813.1" "2755.0" "2681.0" "2932.1" "2845.9" "2936.1" "2804.7" "" "" "" "" "" "" "" "" "" "" "2160.4" "1938.7" "2068.4" "1884.8" "1905.4" "2011.5" "2052.9" "2078.4" "2936.1" "2280.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490484038664760531" "False" "High" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "0.000" "False" "144.009" "44" "14" "57" "14" "466" "52.1" "5.52" "193.21" "14" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "3" "0" "1.036" "1.004" "1.074" "1.072" "1.027" "1.016" "1.033" "0.995" "1.067" "2921.2" "3025.8" "2932.8" "3136.0" "3131.0" "3000.3" "2967.1" "3018.9" "2907.7" "3115.9" "" "" "" "" "" "" "" "" "" "" "2346.2" "2183.3" "2329.6" "2101.1" "2165.5" "2251.1" "2077.4" "2204.7" "2907.7" "2533.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4996428185622591073" "False" "High" "IsMasterProtein" "Q9NZB2" "Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2" "0.000" "False" "143.950" "23" "19" "23" "19" "1118" "121.8" "8.88" "95.77" "19" "" "plasma membrane;other membranes;cytosol;nucleus" "" "" "23196" "ENSG00000048828" "FAM120A" "A6NGU0; C4AMC6; hsa:23196; O60649; Q14688; Q4VXF4; Q4VXF5; Q4VXG2; Q86V69; Q96I21; Q9NZB1; Q9NZB2" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.028" "1.023" "1.011" "0.980" "1.042" "0.973" "1.032" "1.038" "1.051" "2006.2" "2063.1" "2051.5" "2028.1" "1966.8" "2090.7" "1951.7" "2070.4" "2081.7" "2109.2" "" "" "" "" "" "" "" "" "" "" "1611.3" "1488.7" "1629.6" "1358.8" "1360.2" "1568.6" "1366.5" "1512.0" "2081.7" "1715.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5190108194104216904" "False" "High" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "0.000" "False" "143.917" "47" "19" "36" "19" "452" "51.3" "8.32" "129.26" "19" "transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "Mitochondrial protein import" "" "1" "0" "1.086" "1.052" "1.063" "1.048" "1.008" "0.895" "1.088" "1.063" "1.014" "3044.6" "3305.3" "3203.7" "3237.8" "3191.4" "3068.7" "2725.9" "3312.1" "3234.9" "3087.2" "" "" "" "" "" "" "" "" "" "" "2445.3" "2385.0" "2544.8" "2169.3" "2207.2" "2302.4" "1908.5" "2418.9" "3234.9" "2510.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7014036665860809700" "False" "High" "IsMasterProtein" "Q13459" "Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3" "0.000" "False" "143.892" "15" "27" "33" "27" "2157" "243.2" "8.75" "109.70" "27" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf00620, Pf00788" "4650" "ENSG00000099331" "MYO9B" "hsa:4650; O75314; Q13459; Q9NUJ2; Q9UHN0" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOA GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity" "Vitamin D receptor pathway" "10" "0" "1.062" "1.002" "1.065" "0.999" "0.965" "0.951" "1.017" "1.019" "0.994" "1962.4" "2084.7" "1965.8" "2090.0" "1959.6" "1892.8" "1865.6" "1995.1" "2000.4" "1949.7" "" "" "" "" "" "" "" "" "" "" "1576.1" "1504.3" "1561.5" "1400.3" "1355.3" "1420.1" "1306.2" "1457.0" "2000.4" "1585.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5241599952766811941" "False" "High" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "0.000" "False" "143.693" "51" "10" "74" "10" "210" "23.3" "5.64" "294.14" "10" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Neutrophil degranulation; Paracetamol ADME; Detoxification of Reactive Oxygen Species; Glutathione conjugation" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "11" "0" "1.029" "1.084" "0.965" "1.057" "1.127" "0.997" "1.014" "1.058" "1.071" "6087.6" "6262.0" "6596.3" "5877.0" "6431.7" "6862.9" "6067.8" "6175.0" "6438.6" "6517.5" "" "" "" "" "" "" "" "" "" "" "4889.5" "4518.5" "5239.6" "3937.6" "4448.2" "5149.1" "4248.3" "4509.6" "6438.6" "5300.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5372925708799750934" "False" "High" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "0.000" "False" "143.522" "39" "23" "54" "23" "597" "68.0" "6.35" "173.39" "23" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "" "3" "0" "1.020" "1.001" "1.010" "1.003" "0.999" "0.999" "0.993" "1.017" "0.996" "4939.5" "5037.6" "4942.8" "4987.7" "4954.1" "4935.5" "4934.8" "4907.3" "5021.9" "4917.4" "" "" "" "" "" "" "" "" "" "" "3967.3" "3635.0" "3926.2" "3341.8" "3426.3" "3703.0" "3455.1" "3583.8" "5021.9" "3999.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8470400305204825802" "False" "High" "IsMasterProtein" "Q9Y485" "DmX-like protein 1 OS=Homo sapiens OX=9606 GN=DMXL1 PE=1 SV=3" "0.000" "False" "143.180" "11" "28" "31" "28" "3027" "337.6" "6.34" "105.85" "28" "other biological processes" "other cell component" "" "Pf00400, Pf12234" "1657" "ENSG00000172869" "DMXL1" "hsa:1657; Q9Y485" "" "" "0" "0" "1.078" "1.036" "1.029" "1.023" "1.025" "0.962" "1.026" "1.024" "1.023" "1939.6" "2090.8" "2008.8" "1996.3" "1984.9" "1989.0" "1866.6" "1989.5" "1986.4" "1984.1" "" "" "" "" "" "" "" "" "" "" "1557.9" "1508.7" "1595.7" "1337.5" "1372.8" "1492.3" "1306.9" "1452.9" "1986.4" "1613.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5217508454541550081" "False" "High" "IsMasterProtein" "P50453" "Serpin B9 OS=Homo sapiens OX=9606 GN=SERPINB9 PE=1 SV=1" "0.000" "False" "143.094" "55" "18" "41" "16" "376" "42.4" "5.86" "149.37" "18" "other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5272" "ENSG00000170542" "SERPINB9" "B2RBW3; hsa:5272; P50453; Q5TD03" "" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "2" "1" "1.032" "1.030" "0.992" "1.001" "1.022" "0.973" "0.985" "0.994" "1.007" "4214.2" "4348.4" "4340.5" "4180.3" "4217.1" "4307.8" "4101.7" "4149.5" "4190.5" "4241.6" "" "" "" "" "" "" "" "" "" "" "3384.8" "3137.7" "3447.8" "2800.8" "2916.6" "3232.0" "2871.8" "3030.4" "4190.5" "3449.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8320203953169685442" "False" "High" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "0.000" "False" "142.796" "54" "17" "33" "17" "334" "37.5" "7.36" "131.96" "17" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Ub-specific processing proteases; Methylation" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Spina bifida; Methylation pathways" "8" "0" "1.021" "1.009" "1.008" "0.995" "1.007" "0.989" "0.936" "0.917" "0.991" "3119.7" "3186.8" "3148.0" "3143.5" "3104.6" "3140.7" "3084.7" "2921.2" "2861.3" "3090.8" "" "" "" "" "" "" "" "" "" "" "2505.7" "2299.5" "2500.5" "2106.2" "2147.1" "2356.4" "2159.8" "2133.4" "2861.3" "2513.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260357318160893257" "False" "High" "IsMasterProtein" "O75439" "Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2" "0.000" "False" "142.497" "40" "17" "35" "16" "489" "54.3" "6.83" "134.09" "17" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "9512" "ENSG00000105819" "PMPCB" "hsa:9512; O60416; O75439; Q96FV4" "Mitochondrial protein import; Processing of SMDT1" "" "2" "1" "0.996" "0.989" "0.961" "0.984" "0.958" "0.913" "0.947" "0.929" "0.961" "3691.7" "3676.3" "3652.2" "3548.8" "3632.6" "3535.3" "3369.2" "3495.7" "3428.8" "3547.1" "" "" "" "" "" "" "" "" "" "" "2965.1" "2652.7" "2901.0" "2377.7" "2512.3" "2652.5" "2358.9" "2552.9" "3428.8" "2884.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "419048109363271085" "False" "High" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "0.000" "False" "142.359" "43" "20" "45" "20" "525" "58.2" "6.92" "156.09" "20" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "Mitochondrial protein import; Mitochondrial protein degradation; Processing of SMDT1" "" "3" "0" "1.021" "1.027" "1.020" "1.007" "0.983" "0.954" "0.952" "0.995" "0.990" "4049.0" "4133.7" "4160.1" "4130.5" "4076.6" "3979.2" "3860.8" "3853.0" "4026.8" "4008.6" "" "" "" "" "" "" "" "" "" "" "3252.1" "2982.8" "3304.5" "2767.4" "2819.4" "2985.6" "2703.1" "2813.8" "4026.8" "3259.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726683976815450871" "False" "High" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "0.000" "False" "141.939" "45" "17" "194" "15" "332" "36.7" "8.27" "553.94" "17" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Pyruvate metabolism" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders" "20" "0" "0.966" "0.995" "0.948" "0.992" "1.002" "0.947" "0.942" "0.927" "0.957" "13590.0" "13128.5" "13522.0" "12886.0" "13480.4" "13621.0" "12869.6" "12795.5" "12604.6" "13004.2" "" "" "" "" "" "" "" "" "" "" "10915.3" "9473.1" "10741.0" "8633.6" "9323.1" "10219.6" "9010.6" "9344.6" "12604.6" "10575.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830366311257218609" "False" "High" "IsMasterProtein" "P48147" "Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2" "0.000" "False" "141.770" "48" "28" "43" "28" "710" "80.6" "5.86" "136.19" "28" "protein metabolism" "cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf02897" "5550" "ENSG00000085377" "PREP" "hsa:5550; P48147; Q8N6D4" "" "" "0" "0" "0.976" "0.980" "0.955" "0.977" "0.980" "0.954" "0.936" "0.929" "0.976" "3933.2" "3839.7" "3852.7" "3756.3" "3843.1" "3856.1" "3754.2" "3679.5" "3655.5" "3837.0" "" "" "" "" "" "" "" "" "" "" "3159.1" "2770.6" "3060.3" "2516.7" "2657.9" "2893.2" "2628.5" "2687.2" "3655.5" "3120.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2006906941817689569" "False" "High" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "0.000" "False" "141.522" "12" "31" "37" "30" "2896" "316.7" "9.13" "113.91" "31" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "" "VEGFA-VEGFR2 signaling" "1" "1" "1.015" "1.102" "1.073" "1.087" "1.134" "1.130" "1.085" "1.122" "1.090" "2121.4" "2152.3" "2337.0" "2277.3" "2306.4" "2406.3" "2396.5" "2302.5" "2379.2" "2313.4" "" "" "" "" "" "" "" "" "" "" "1703.9" "1553.0" "1856.3" "1525.8" "1595.1" "1805.4" "1677.9" "1681.6" "2379.2" "1881.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9204758010535676815" "False" "High" "IsMasterProtein" "Q641Q2" "WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3" "0.000" "False" "141.437" "19" "18" "26" "3" "1341" "147.1" "4.81" "98.42" "18" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "387680" "ENSG00000099290" "WASHC2A" "A2A3S2; A2A3U6; hsa:387680; Q5SNT6; Q641Q2; Q6DHY0" "" "" "0" "0" "0.991" "1.048" "1.145" "1.098" "0.913" "1.014" "1.116" "0.878" "1.003" "106.3" "105.3" "111.4" "121.7" "116.7" "97.1" "107.8" "118.7" "93.3" "106.7" "" "" "" "" "" "" "" "" "" "" "85.4" "76.0" "88.5" "81.5" "80.7" "72.8" "75.5" "86.7" "93.3" "86.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5506725299494211183" "False" "High" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "0.000" "False" "141.402" "62" "16" "50" "16" "263" "29.5" "6.61" "156.52" "16" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.929" "1.005" "0.968" "1.022" "1.031" "1.012" "1.001" "0.976" "0.990" "4157.1" "3860.1" "4179.3" "4026.1" "4247.4" "4285.0" "4207.3" "4161.4" "4056.6" "4117.2" "" "" "" "" "" "" "" "" "" "" "3339.0" "2785.3" "3319.8" "2697.5" "2937.5" "3215.0" "2945.8" "3039.0" "4056.6" "3348.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6590851508053806454" "False" "High" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "0.000" "False" "141.389" "31" "20" "34" "20" "826" "92.2" "7.90" "110.28" "20" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "" "4" "0" "1.040" "0.994" "1.003" "1.031" "0.997" "0.940" "0.954" "0.953" "1.028" "1904.5" "1980.7" "1893.6" "1909.9" "1964.1" "1898.3" "1789.9" "1817.5" "1815.8" "1957.7" "" "" "" "" "" "" "" "" "" "" "1529.7" "1429.2" "1504.2" "1279.7" "1358.4" "1424.3" "1253.2" "1327.4" "1815.8" "1592.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5070657134179306573" "False" "High" "IsMasterProtein" "P55160" "Nck-associated protein 1-like OS=Homo sapiens OX=9606 GN=NCKAP1L PE=1 SV=3" "0.000" "False" "141.186" "23" "23" "44" "23" "1127" "128.1" "6.86" "149.72" "23" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf09735" "3071" "ENSG00000123338" "NCKAP1L" "B4DUT5; hsa:3071; P55160; Q52LW0" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Hematopoietic stem cell differentiation; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia" "11" "0" "0.993" "0.998" "0.949" "0.956" "0.969" "0.945" "0.948" "1.017" "0.961" "3296.8" "3272.2" "3288.7" "3130.2" "3152.9" "3194.8" "3114.2" "3125.7" "3352.8" "3168.0" "" "" "" "" "" "" "" "" "" "" "2647.9" "2361.1" "2612.3" "2097.2" "2180.6" "2397.0" "2180.4" "2282.7" "3352.8" "2576.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3689423794866279404" "False" "High" "IsMasterProtein" "Q8N8A2" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3" "0.000" "False" "141.108" "24" "19" "30" "17" "993" "107.5" "6.30" "112.97" "19" "" "" "" "Pf12796" "91526" "ENSG00000065413" "ANKRD44" "hsa:91526; Q53SL9; Q6P480; Q86VL5; Q8IZ72; Q8N8A2; Q9UFA4" "" "" "0" "1" "0.952" "1.002" "0.981" "0.945" "0.917" "0.900" "0.987" "0.937" "0.970" "2516.9" "2395.1" "2521.3" "2469.4" "2379.7" "2308.2" "2266.0" "2485.1" "2358.8" "2442.2" "" "" "" "" "" "" "" "" "" "" "2021.6" "1728.3" "2002.7" "1654.5" "1645.8" "1731.8" "1586.5" "1814.9" "2358.8" "1986.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6102726942936219024" "False" "High" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "0.000" "False" "140.962" "26" "36" "48" "36" "1382" "166.5" "6.79" "138.78" "36" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; NF1 copy number variation syndrome" "9" "0" "0.930" "1.098" "0.981" "0.955" "0.988" "1.010" "0.994" "0.988" "1.016" "2907.8" "2702.9" "3193.4" "2853.3" "2776.6" "2872.7" "2937.2" "2890.2" "2872.5" "2954.0" "" "" "" "" "" "" "" "" "" "" "2335.5" "1950.4" "2536.6" "1911.7" "1920.3" "2155.3" "2056.5" "2110.7" "2872.5" "2402.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5146194763557846941" "False" "High" "IsMasterProtein" "Q9Y613" "FH1/FH2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FHOD1 PE=1 SV=3" "0.000" "False" "140.937" "24" "22" "27" "22" "1164" "126.5" "6.39" "99.15" "22" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf18382" "29109" "ENSG00000135723" "FHOD1" "hsa:29109; Q59F76; Q6Y1F2; Q76MS8; Q8N521; Q9Y613" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.067" "0.956" "1.069" "1.017" "0.960" "1.004" "1.090" "1.018" "1.008" "1294.8" "1381.5" "1238.1" "1384.7" "1316.9" "1243.2" "1299.6" "1410.9" "1317.8" "1305.8" "" "" "" "" "" "" "" "" "" "" "1040.0" "996.9" "983.4" "927.8" "910.8" "932.7" "909.9" "1030.4" "1317.8" "1062.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2120449807322374936" "False" "High" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "0.000" "False" "140.744" "53" "16" "40" "16" "365" "41.0" "5.16" "158.21" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "Nucleotide-binding oligomerization domain (NOD) pathway" "3" "0" "0.999" "1.044" "1.033" "1.024" "1.012" "1.023" "1.089" "1.040" "1.016" "4673.7" "4667.7" "4877.8" "4829.5" "4786.0" "4730.5" "4780.0" "5087.9" "4859.0" "4747.4" "" "" "" "" "" "" "" "" "" "" "3753.8" "3368.1" "3874.6" "3235.7" "3310.0" "3549.2" "3346.7" "3715.7" "4859.0" "3860.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5810129024139572187" "False" "High" "IsMasterProtein" "P34931" "Heat shock 70 kDa protein 1-like OS=Homo sapiens OX=9606 GN=HSPA1L PE=1 SV=2" "0.000" "False" "140.520" "30" "17" "89" "1" "641" "70.3" "6.02" "298.26" "17" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3305" "ENSG00000204390; ENSG00000206383; ENSG00000234258; ENSG00000236251" "HSPA1L" "A6NNB0; B0UXW8; hsa:3305; O75634; P34931; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Attenuation phase" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection" "8" "0" "0.869" "0.903" "1.211" "0.978" "0.862" "1.122" "0.987" "0.964" "1.069" "262.3" "228.0" "236.9" "317.7" "256.5" "226.0" "294.4" "258.9" "252.8" "280.5" "" "" "" "" "" "" "" "" "" "" "210.7" "164.5" "188.2" "212.9" "177.4" "169.6" "206.2" "189.1" "252.8" "228.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254798804738061271" "False" "High" "IsMasterProtein" "O60271" "C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4" "0.000" "False" "140.512" "25" "28" "36" "26" "1321" "146.1" "5.15" "123.76" "28" "transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "9043" "ENSG00000008294" "SPAG9" "A6H8U5; A8MSX0; B4DHH2; hsa:9043; O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811" "Myogenesis" "" "1" "0" "1.006" "0.972" "1.012" "0.984" "0.978" "0.992" "0.973" "1.029" "1.014" "2602.1" "2618.6" "2528.8" "2633.3" "2561.7" "2544.2" "2582.0" "2532.2" "2678.8" "2638.8" "" "" "" "" "" "" "" "" "" "" "2090.0" "1889.5" "2008.7" "1764.3" "1771.7" "1908.8" "1807.8" "1849.3" "2678.8" "2146.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2098807042560158640" "False" "High" "IsMasterProtein" "P13489" "Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2" "0.000" "False" "140.337" "43" "15" "29" "15" "461" "49.9" "4.82" "119.67" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf13516, Pf18779" "6050" "ENSG00000023191; ENSG00000276230" "RNH1" "hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6" "" "" "0" "0" "1.037" "0.979" "1.044" "1.056" "0.984" "1.042" "1.012" "1.008" "1.021" "1994.3" "2067.6" "1952.1" "2082.9" "2105.6" "1962.5" "2077.1" "2017.7" "2010.9" "2036.2" "" "" "" "" "" "" "" "" "" "" "1601.8" "1491.9" "1550.6" "1395.5" "1456.2" "1472.4" "1454.3" "1473.5" "2010.9" "1655.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348431233397446306" "False" "High" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "0.000" "False" "140.277" "37" "13" "43" "13" "437" "49.0" "5.71" "139.09" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "Translation factors" "6" "0" "1.023" "1.039" "1.010" "0.983" "0.971" "0.977" "1.001" "0.984" "0.984" "3700.4" "3785.6" "3843.0" "3737.0" "3639.0" "3594.1" "3615.9" "3702.4" "3641.6" "3642.5" "" "" "" "" "" "" "" "" "" "" "2972.1" "2731.6" "3052.6" "2503.8" "2516.8" "2696.6" "2531.7" "2703.9" "3641.6" "2962.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535897714363242613" "False" "High" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "0.000" "False" "140.166" "51" "14" "35" "14" "361" "41.5" "6.60" "133.68" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "Anchoring of the basal body to the plasma membrane" "2q37 copy number variation syndrome" "2" "0" "1.010" "1.014" "0.985" "0.992" "1.015" "0.952" "1.014" "0.980" "0.959" "2887.5" "2915.6" "2928.1" "2843.8" "2864.4" "2930.5" "2747.8" "2926.9" "2829.6" "2770.3" "" "" "" "" "" "" "" "" "" "" "2319.2" "2103.8" "2325.9" "1905.4" "1981.0" "2198.7" "1923.8" "2137.5" "2829.6" "2252.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1764632123327779223" "False" "High" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "0.000" "False" "140.160" "36" "18" "35" "18" "587" "63.5" "4.68" "121.51" "18" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "12" "0" "1.021" "1.000" "1.026" "0.990" "1.022" "0.924" "0.992" "0.918" "0.981" "2522.8" "2575.2" "2523.4" "2589.2" "2497.3" "2578.5" "2332.2" "2502.8" "2316.9" "2475.3" "" "" "" "" "" "" "" "" "" "" "2026.3" "1858.2" "2004.4" "1734.8" "1727.2" "1934.6" "1632.9" "1827.8" "2316.9" "2013.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6960359147395003723" "False" "High" "IsMasterProtein" "P15498" "Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4" "0.000" "False" "140.144" "28" "25" "43" "24" "845" "98.3" "6.62" "124.70" "25" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621" "7409" "ENSG00000141968" "VAV1" "B4DVK9; hsa:7409; M0QXX6; P15498; Q15860" "Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; Azathioprine ADME; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway" "Prolactin signaling pathway; B cell receptor signaling pathway; Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor signaling pathway" "38" "1" "0.991" "0.989" "0.960" "0.914" "0.953" "0.877" "0.882" "0.907" "0.936" "4082.4" "4046.4" "4039.2" "3918.1" "3732.3" "3891.4" "3578.6" "3598.9" "3701.7" "3819.9" "" "" "" "" "" "" "" "" "" "" "3279.0" "2919.8" "3208.4" "2625.1" "2581.3" "2919.6" "2505.5" "2628.3" "3701.7" "3106.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828229649447777005" "False" "High" "IsMasterProtein" "P31153" "S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1" "0.000" "False" "139.475" "52" "17" "58" "17" "395" "43.6" "6.48" "172.17" "17" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00438, Pf02772, Pf02773" "4144" "ENSG00000168906" "MAT2A" "A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5" "Methylation" "Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways" "5" "0" "0.981" "0.988" "0.967" "0.973" "0.986" "0.944" "0.984" "0.932" "0.969" "4036.7" "3958.4" "3988.4" "3904.0" "3927.2" "3981.8" "3811.5" "3971.9" "3760.9" "3910.0" "" "" "" "" "" "" "" "" "" "" "3242.3" "2856.3" "3168.1" "2615.7" "2716.1" "2987.5" "2668.6" "2900.7" "3760.9" "3179.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302543892740036521" "False" "High" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "0.000" "False" "139.262" "46" "14" "39" "14" "282" "31.5" "4.55" "152.00" "14" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "1.033" "1.024" "1.029" "1.029" "1.048" "1.018" "1.049" "1.050" "1.005" "5205.2" "5375.3" "5329.2" "5357.3" "5355.4" "5452.5" "5297.6" "5457.7" "5467.4" "5230.2" "" "" "" "" "" "" "" "" "" "" "4180.7" "3878.7" "4233.2" "3589.4" "3703.8" "4090.9" "3709.1" "3985.7" "5467.4" "4253.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8637323044109722120" "False" "High" "IsMasterProtein" "Q2NKX8" "DNA excision repair protein ERCC-6-like OS=Homo sapiens OX=9606 GN=ERCC6L PE=1 SV=1" "0.000" "False" "139.168" "27" "27" "32" "27" "1250" "141.0" "5.31" "114.32" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "54821" "ENSG00000186871" "ERCC6L" "hsa:54821; Q2NKX8; Q8NCI1; Q96H93; Q9NXQ8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.000" "1.023" "1.038" "1.005" "0.988" "0.971" "1.039" "1.092" "1.041" "1826.9" "1826.2" "1869.7" "1896.7" "1836.0" "1804.1" "1773.7" "1898.7" "1995.6" "1902.6" "" "" "" "" "" "" "" "" "" "" "1467.3" "1317.8" "1485.2" "1270.8" "1269.8" "1353.5" "1241.8" "1386.6" "1995.6" "1547.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7388585802174213380" "False" "High" "IsMasterProtein" "Q06187" "Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3" "0.000" "False" "138.850" "38" "25" "49" "25" "659" "76.2" "7.77" "155.88" "25" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf00169, Pf00779, Pf07714" "695" "ENSG00000010671" "BTK" "B2RAW1; hsa:695; Q06187; Q32ML5" "Potential therapeutics for SARS; ER-Phagosome pathway; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; G alpha (12/13) signalling events; G alpha (q) signalling events; RHO GTPases Activate WASPs and WAVEs; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); DAP12 signaling; G beta:gamma signalling through BTK" "IL-5 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "20" "0" "1.037" "1.058" "0.993" "1.015" "1.056" "0.957" "0.969" "0.987" "1.035" "5577.2" "5781.4" "5898.3" "5535.9" "5659.8" "5887.3" "5339.0" "5404.8" "5504.9" "5772.6" "" "" "" "" "" "" "" "" "" "" "4479.5" "4171.7" "4685.2" "3709.0" "3914.3" "4417.2" "3738.1" "3947.2" "5504.9" "4694.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064458318068970757" "False" "High" "IsMasterProtein" "Q96QK1" "Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2" "0.000" "False" "138.728" "31" "22" "39" "22" "796" "91.6" "5.49" "143.08" "22" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf03635" "55737" "ENSG00000069329" "VPS35" "hsa:55737; Q561W2; Q96QK1; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2" "WNT ligand biogenesis and trafficking" "" "1" "0" "1.010" "1.017" "1.003" "0.994" "1.006" "0.968" "0.994" "0.974" "1.001" "4237.8" "4282.1" "4310.5" "4249.0" "4211.2" "4263.9" "4100.7" "4211.9" "4127.2" "4240.7" "" "" "" "" "" "" "" "" "" "" "3403.8" "3089.8" "3424.0" "2846.8" "2912.5" "3199.1" "2871.1" "3076.0" "4127.2" "3448.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6465314109903613014" "False" "High" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "0.000" "False" "138.716" "48" "23" "42" "23" "494" "56.4" "6.96" "137.82" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Regulation of HSF1-mediated heat shock response" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "4" "0" "1.054" "1.032" "0.977" "0.995" "0.996" "0.917" "1.076" "1.056" "1.025" "3739.2" "3942.7" "3857.9" "3654.6" "3721.0" "3723.8" "3428.9" "4023.8" "3949.5" "3832.1" "" "" "" "" "" "" "" "" "" "" "3003.3" "2844.9" "3064.5" "2448.6" "2573.4" "2793.9" "2400.7" "2938.6" "3949.5" "3116.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197563919464376950" "False" "High" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "0.000" "False" "138.672" "15" "27" "35" "27" "2240" "243.7" "7.88" "114.49" "27" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "1.073" "1.070" "1.116" "1.085" "1.022" "1.072" "1.122" "1.081" "1.057" "2473.4" "2654.0" "2646.2" "2760.3" "2684.3" "2526.6" "2652.7" "2775.5" "2674.1" "2613.7" "" "" "" "" "" "" "" "" "" "" "1986.6" "1915.1" "2102.0" "1849.4" "1856.5" "1895.7" "1857.3" "2027.0" "2674.1" "2125.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2192359693732382121" "False" "High" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "0.000" "False" "138.537" "51" "15" "44" "15" "338" "38.3" "5.53" "184.26" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "1" "0" "1.054" "1.058" "0.989" "1.002" "1.021" "0.959" "1.017" "1.038" "1.023" "4367.2" "4605.0" "4619.7" "4318.1" "4374.0" "4460.5" "4189.6" "4441.4" "4532.2" "4466.6" "" "" "" "" "" "" "" "" "" "" "3507.7" "3322.8" "3669.6" "2893.1" "3025.1" "3346.7" "2933.3" "3243.6" "4532.2" "3632.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236542177406705002" "False" "High" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "0.000" "False" "138.204" "44" "14" "70" "12" "415" "45.6" "5.58" "246.25" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome" "5" "0" "0.993" "1.010" "1.005" "0.964" "0.970" "0.947" "0.991" "1.000" "0.995" "2900.0" "2879.3" "2929.3" "2915.0" "2795.7" "2813.8" "2747.0" "2873.1" "2900.7" "2886.2" "" "" "" "" "" "" "" "" "" "" "2329.2" "2077.6" "2326.9" "1953.1" "1933.5" "2111.1" "1923.3" "2098.3" "2900.7" "2347.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048249212605468111" "False" "High" "IsMasterProtein" "P30876" "DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1" "0.000" "False" "138.166" "21" "20" "34" "20" "1174" "133.8" "6.87" "112.15" "20" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "5431" "ENSG00000047315" "POLR2B" "A8K1A8; hsa:5431; P30876; Q8IZ61" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.035" "1.024" "1.039" "1.046" "0.996" "1.032" "1.061" "1.033" "1.019" "2453.1" "2539.8" "2511.5" "2549.6" "2567.1" "2443.7" "2531.5" "2603.8" "2533.7" "2499.6" "" "" "" "" "" "" "" "" "" "" "1970.3" "1832.6" "1994.9" "1708.2" "1775.5" "1833.4" "1772.4" "1901.6" "2533.7" "2032.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "250780751349012114" "False" "High" "IsMasterProtein" "Cont_Q29443" "Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1" "0.000" "True" "138.131" "37" "22" "30" "22" "704" "77.7" "7.08" "113.89" "22" "stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00405" "280705" "" "TF" "bta:280705; Q0IIK2; Q29443" "" "" "0" "0" "0.922" "0.898" "1.009" "0.932" "1.056" "1.533" "0.972" "1.012" "1.048" "2177.1" "2008.4" "1956.1" "2196.3" "2028.6" "2299.0" "3336.8" "2117.1" "2203.3" "2281.4" "" "" "" "" "" "" "" "" "" "" "1748.7" "1449.2" "1553.8" "1471.5" "1403.0" "1724.9" "2336.2" "1546.1" "2203.3" "1855.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7944368975479606522" "False" "High" "IsMasterProtein" "O94979" "Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3" "0.000" "False" "137.943" "18" "20" "32" "20" "1220" "132.9" "6.89" "120.24" "20" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf12931" "22872" "ENSG00000138674" "SEC31A" "B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; hsa:22872; O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "6" "0" "0.981" "0.990" "1.031" "0.987" "0.955" "1.000" "0.996" "0.983" "0.993" "2053.0" "2014.2" "2033.4" "2116.4" "2025.3" "1960.6" "2053.3" "2044.5" "2018.7" "2039.5" "" "" "" "" "" "" "" "" "" "" "1648.9" "1453.4" "1615.2" "1418.0" "1400.7" "1471.0" "1437.6" "1493.1" "2018.7" "1658.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6939588679820243468" "False" "High" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "0.000" "False" "137.863" "56" "16" "56" "14" "301" "33.9" "8.38" "184.26" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "15" "2" "1.060" "1.039" "1.027" "0.978" "0.990" "1.030" "1.023" "0.986" "1.025" "4407.3" "4673.7" "4577.9" "4526.8" "4311.3" "4363.5" "4540.5" "4510.6" "4347.8" "4517.4" "" "" "" "" "" "" "" "" "" "" "3539.9" "3372.4" "3636.4" "3032.9" "2981.8" "3273.8" "3179.0" "3294.1" "4347.8" "3673.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047119725647514999" "False" "High" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "0.000" "False" "137.691" "31" "17" "56" "17" "611" "69.1" "5.73" "180.60" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "16" "0" "1.016" "1.098" "1.096" "1.045" "1.106" "1.084" "1.091" "1.089" "1.043" "3566.8" "3624.7" "3915.0" "3908.9" "3727.5" "3945.9" "3867.3" "3890.6" "3884.8" "3719.6" "" "" "" "" "" "" "" "" "" "" "2864.8" "2615.5" "3109.8" "2618.9" "2578.0" "2960.5" "2707.7" "2841.4" "3884.8" "3024.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2043411241930693309" "False" "High" "IsMasterProtein" "Q96JM3" "Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2" "0.000" "False" "137.530" "33" "23" "33" "23" "812" "89.0" "8.44" "114.43" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "" "283489" "ENSG00000198824" "CHAMP1" "B3KU06; hsa:283489; Q6P181; Q8NC88; Q96JM3; Q9BST0" "" "" "0" "0" "1.029" "1.017" "1.024" "0.988" "1.004" "1.009" "1.034" "1.031" "1.028" "3080.4" "3171.3" "3132.8" "3153.0" "3043.4" "3091.9" "3107.5" "3186.0" "3175.3" "3166.2" "" "" "" "" "" "" "" "" "" "" "2474.2" "2288.3" "2488.5" "2112.5" "2104.8" "2319.8" "2175.7" "2326.7" "3175.3" "2574.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-61842363996650095" "False" "High" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "0.000" "False" "137.284" "63" "12" "30" "12" "302" "33.8" "5.49" "119.65" "12" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Metabolism of polyamines" "Methionine de novo and salvage pathway; Amino acid metabolism" "3" "0" "1.010" "0.998" "0.992" "0.977" "1.013" "0.955" "0.984" "0.952" "1.011" "2080.0" "2100.6" "2075.0" "2063.0" "2032.1" "2107.9" "1986.2" "2046.0" "1979.9" "2103.1" "" "" "" "" "" "" "" "" "" "" "1670.7" "1515.7" "1648.2" "1382.2" "1405.4" "1581.5" "1390.6" "1494.2" "1979.9" "1710.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3042753504910158627" "False" "High" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "0.000" "False" "137.200" "59" "16" "39" "16" "333" "35.1" "8.38" "132.42" "16" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "Respiratory electron transport" "" "1" "0" "0.963" "1.000" "0.904" "0.919" "0.919" "0.883" "0.936" "0.865" "0.911" "4445.2" "4279.2" "4446.4" "4020.6" "4085.8" "4086.5" "3925.3" "4160.4" "3846.7" "4048.1" "" "" "" "" "" "" "" "" "" "" "3570.3" "3087.7" "3531.9" "2693.8" "2825.8" "3066.0" "2748.3" "3038.4" "3846.7" "3292.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8428260618384848940" "False" "High" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "0.000" "False" "137.042" "34" "25" "35" "24" "972" "109.4" "5.00" "121.64" "25" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; Ciliary landscape" "4" "0" "0.975" "1.012" "0.970" "1.008" "0.999" "0.982" "1.010" "0.971" "1.017" "1750.1" "1706.2" "1771.8" "1698.3" "1764.8" "1747.6" "1718.9" "1768.4" "1699.7" "1780.3" "" "" "" "" "" "" "" "" "" "" "1405.7" "1231.2" "1407.4" "1137.9" "1220.6" "1311.2" "1203.5" "1291.5" "1699.7" "1447.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7480340352347879805" "False" "High" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "0.000" "False" "136.744" "32" "17" "24" "17" "802" "92.2" "8.18" "97.28" "17" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "mRNA Splicing - Major Pathway" "" "1" "0" "1.009" "1.057" "0.998" "0.983" "0.992" "0.958" "0.960" "0.988" "1.015" "1687.9" "1702.5" "1783.3" "1683.9" "1660.0" "1674.3" "1616.5" "1619.6" "1667.8" "1712.6" "" "" "" "" "" "" "" "" "" "" "1355.7" "1228.4" "1416.5" "1128.2" "1148.1" "1256.2" "1131.8" "1182.8" "1667.8" "1392.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7405730642826192701" "False" "High" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "0.000" "False" "136.665" "44" "16" "40" "16" "522" "56.2" "8.50" "150.66" "16" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "11" "0" "1.040" "0.978" "1.006" "0.959" "0.985" "0.931" "0.876" "0.915" "0.938" "3573.9" "3717.1" "3494.8" "3595.8" "3426.7" "3521.6" "3326.2" "3130.4" "3269.4" "3350.8" "" "" "" "" "" "" "" "" "" "" "2870.5" "2682.2" "2776.0" "2409.2" "2369.9" "2642.2" "2328.8" "2286.1" "3269.4" "2725.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741293636862823993" "False" "High" "IsMasterProtein" "Q5T1M5" "FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2" "0.000" "False" "136.612" "21" "23" "25" "23" "1219" "133.5" "5.20" "99.83" "23" "transport" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00254" "23307" "ENSG00000119321" "FKBP15" "hsa:23307; Q05DK8; Q5T1M2; Q5T1M5; Q6DD85; Q9Y4D0" "" "TYROBP causal network in microglia" "1" "0" "1.029" "0.982" "0.967" "0.958" "0.932" "0.878" "0.938" "0.972" "1.005" "2848.3" "2931.5" "2798.0" "2755.0" "2727.2" "2654.1" "2500.1" "2672.8" "2769.5" "2863.9" "" "" "" "" "" "" "" "" "" "" "2287.7" "2115.3" "2222.6" "1845.9" "1886.2" "1991.3" "1750.5" "1951.9" "2769.5" "2329.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909350322516910922" "False" "High" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "0.000" "False" "136.606" "39" "20" "39" "20" "546" "61.9" "6.52" "135.15" "20" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "Other interleukin signaling" "" "1" "0" "1.070" "1.085" "1.108" "1.064" "1.033" "1.021" "1.034" "1.066" "1.066" "2518.3" "2695.3" "2732.6" "2789.3" "2679.1" "2601.8" "2571.1" "2605.1" "2684.5" "2684.6" "" "" "" "" "" "" "" "" "" "" "2022.6" "1944.9" "2170.6" "1868.8" "1852.9" "1952.1" "1800.2" "1902.5" "2684.5" "2183.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8716615983158352243" "False" "High" "IsMasterProtein" "P27695" "DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "0.000" "False" "136.584" "51" "12" "39" "12" "318" "35.5" "8.12" "155.38" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823; ENSG00000291796" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "10" "0" "1.034" "1.008" "1.048" "1.090" "1.062" "1.043" "1.005" "1.050" "1.031" "2844.4" "2942.4" "2866.2" "2982.1" "3101.7" "3021.7" "2967.4" "2857.7" "2985.3" "2933.1" "" "" "" "" "" "" "" "" "" "" "2284.6" "2123.1" "2276.7" "1998.0" "2145.2" "2267.1" "2077.7" "2087.0" "2985.3" "2385.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613471079569612470" "False" "High" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "0.000" "False" "136.423" "38" "17" "78" "16" "589" "64.1" "8.22" "248.25" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; Hippocampal synaptogenesis and neurogenesis" "4" "1" "1.025" "1.060" "1.002" "1.034" "1.035" "1.008" "1.017" "1.006" "1.003" "5797.3" "5941.2" "6142.8" "5807.7" "5995.0" "5999.6" "5841.4" "5894.0" "5833.1" "5814.9" "" "" "" "" "" "" "" "" "" "" "4656.3" "4287.0" "4879.4" "3891.1" "4146.2" "4501.4" "4089.8" "4304.4" "5833.1" "4728.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2128989799875943394" "False" "High" "IsMasterProtein" "Q92888" "Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2" "0.000" "False" "136.254" "31" "24" "44" "24" "912" "102.4" "5.66" "148.91" "24" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00621, Pf09128, Pf17838" "9138" "ENSG00000076928" "ARHGEF1" "hsa:9138; O00513; Q6NX52; Q8N4J4; Q92888; Q96BF4; Q96F17; Q9BSB1" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "9" "0" "1.018" "0.988" "1.044" "1.019" "0.970" "0.993" "1.011" "1.021" "1.052" "2663.7" "2710.8" "2631.8" "2780.6" "2713.1" "2584.9" "2644.6" "2693.0" "2720.3" "2802.9" "" "" "" "" "" "" "" "" "" "" "2139.5" "1956.1" "2090.5" "1863.0" "1876.4" "1939.4" "1851.6" "1966.7" "2720.3" "2279.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479793662138796228" "False" "High" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "0.000" "False" "136.242" "37" "20" "41" "20" "599" "67.3" "8.34" "147.74" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "OAS antiviral response; Interferon alpha/beta signaling" "" "2" "0" "0.960" "1.025" "1.000" "1.005" "1.007" "0.993" "0.964" "0.936" "0.978" "4229.1" "4059.6" "4333.0" "4230.8" "4249.9" "4256.8" "4199.1" "4077.2" "3956.7" "4136.3" "" "" "" "" "" "" "" "" "" "" "3396.8" "2929.3" "3441.8" "2834.6" "2939.3" "3193.8" "2940.0" "2977.6" "3956.7" "3363.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5122002380756434681" "False" "High" "IsMasterProtein" "Q9Y6E2" "eIF5-mimic protein 1 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1" "0.000" "False" "136.232" "49" "21" "55" "18" "419" "48.1" "6.68" "188.17" "21" "other biological processes" "other cell component" "" "Pf02020" "28969" "ENSG00000136261" "BZW2" "A4D123; hsa:28969; Q3B779; Q96JW5; Q9H3F7; Q9Y6E2" "" "" "0" "3" "0.994" "1.003" "1.000" "0.983" "0.990" "0.953" "0.962" "0.978" "0.975" "5904.0" "5869.4" "5919.5" "5905.3" "5805.7" "5846.1" "5627.7" "5677.7" "5776.3" "5756.7" "" "" "" "" "" "" "" "" "" "" "4742.1" "4235.2" "4702.0" "3956.5" "4015.3" "4386.2" "3940.3" "4146.4" "5776.3" "4681.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3062212909163771863" "False" "High" "IsMasterProtein" "P19838" "Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2" "0.000" "False" "135.944" "28" "22" "31" "22" "968" "105.3" "5.40" "110.27" "22" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4790" "ENSG00000109320" "NFKB1" "A8K5Y5; B3KVE8; hsa:4790; P19838; Q68D84; Q86V43; Q8N4X7; Q9NZC0" "FCERI mediated NF-kB activation; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; Activation of NF-kappaB in B cells; HCMV Early Events; Neutrophil degranulation; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; PDGF pathway; Apoptosis; T cell receptor and co-stimulatory signaling; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Selenium metabolism and selenoproteins; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; Oxidative stress response; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; Nonalcoholic fatty liver disease; LTF danger signal response pathway; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Canonical NF-kB pathway; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Aspirin and miRNAs; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; FGF23 signaling in hypophosphatemic rickets and related disorders; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; RAS and bradykinin pathways in COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Prostaglandin signaling; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Inclusion body myositis; Alzheimer's disease; Th17 cell differentiation pathway; Lung pathology of COVID-19; Ulcerative colitis signaling; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Inflammatory bowel disease signaling; Role of ROS in COVID-19 endothelial dysfunction; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; TROP2 regulatory signaling; Autophagy in pancreatic ductal adenocarcinoma; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; 10q22q23 copy number variation; IL-19 signaling pathway; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; Notch signaling pathway; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway" "151" "0" "1.006" "1.014" "1.035" "1.009" "0.999" "0.954" "1.003" "1.013" "1.015" "2897.6" "2913.5" "2938.7" "2997.8" "2924.1" "2895.8" "2765.3" "2906.4" "2936.3" "2941.9" "" "" "" "" "" "" "" "" "" "" "2327.3" "2102.3" "2334.3" "2008.5" "2022.3" "2172.7" "1936.1" "2122.6" "2936.3" "2392.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5518628090009250384" "False" "High" "IsMasterProtein" "Q3V6T2" "Girdin OS=Homo sapiens OX=9606 GN=CCDC88A PE=1 SV=2" "0.000" "False" "135.903" "17" "30" "36" "30" "1871" "215.9" "6.21" "122.13" "30" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "55704" "ENSG00000115355" "CCDC88A" "A1IGE7; B7ZM78; C9JG83; hsa:55704; Q3V6T2; Q53SF1; Q581G3; Q5HYD0; Q7Z339; Q7Z3C5" "RND3 GTPase cycle; RND1 GTPase cycle" "Mesodermal commitment pathway" "3" "0" "1.018" "1.013" "1.001" "1.011" "1.004" "0.994" "1.005" "1.064" "1.035" "2372.9" "2416.5" "2404.1" "2376.3" "2398.4" "2381.8" "2359.3" "2385.4" "2525.3" "2455.2" "" "" "" "" "" "" "" "" "" "" "1905.9" "1743.7" "1909.7" "1592.1" "1658.8" "1787.0" "1651.9" "1742.1" "2525.3" "1996.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681400762000750361" "False" "High" "IsMasterProtein" "O60749" "Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2" "0.000" "False" "135.878" "41" "18" "32" "15" "519" "58.4" "5.12" "116.31" "18" "cell organization and biogenesis;transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6643" "ENSG00000205302" "SNX2" "B3KN44; B4DEK4; B7Z408; hsa:6643; O43650; O60749; P82862; Q53XK8; Q597H6; Q9BTS8" "Golgi Associated Vesicle Biogenesis" "" "1" "2" "1.001" "0.956" "0.971" "0.980" "0.934" "0.942" "0.962" "0.953" "0.951" "3170.5" "3174.2" "3030.5" "3077.7" "3107.7" "2961.4" "2987.6" "3050.8" "3020.8" "3014.5" "" "" "" "" "" "" "" "" "" "" "2546.5" "2290.4" "2407.2" "2062.0" "2149.3" "2221.9" "2091.8" "2228.0" "3020.8" "2451.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9100750251972445181" "False" "High" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "0.000" "False" "135.870" "17" "21" "34" "21" "1478" "164.9" "5.22" "119.92" "21" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "" "2" "0" "0.986" "0.997" "0.989" "1.032" "1.059" "1.011" "1.044" "0.998" "1.045" "2134.4" "2105.5" "2128.6" "2110.8" "2203.3" "2259.7" "2157.8" "2227.4" "2130.4" "2229.8" "" "" "" "" "" "" "" "" "" "" "1714.3" "1519.3" "1690.8" "1414.3" "1523.8" "1695.4" "1510.8" "1626.7" "2130.4" "1813.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-815619529761870657" "False" "High" "IsMasterProtein" "Q6P996" "Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2" "0.000" "False" "135.650" "30" "18" "30" "18" "788" "86.7" "5.38" "116.60" "18" "other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00282" "23042" "ENSG00000179889; ENSG00000275498" "PDXDC1" "B4DR55; B4DSL3; E7EMH5; E7EPL4; H3BNZ1; hsa:23042; O00236; Q4F6X7; Q6P996; Q6PID7; Q86YF1; Q8N4Q9; Q8TBS5" "" "" "0" "0" "1.070" "1.025" "0.980" "1.021" "0.968" "0.942" "1.041" "1.034" "1.017" "1923.4" "2057.7" "1971.1" "1884.2" "1963.9" "1861.4" "1811.9" "2002.6" "1989.5" "1955.4" "" "" "" "" "" "" "" "" "" "" "1544.9" "1484.7" "1565.7" "1262.4" "1358.2" "1396.6" "1268.6" "1462.5" "1989.5" "1590.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92352165089450524" "False" "High" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "0.000" "False" "135.627" "38" "16" "39" "16" "546" "59.2" "4.36" "154.80" "16" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "" "VEGFA-VEGFR2 signaling; mRNA processing" "2" "0" "0.997" "0.976" "0.990" "0.969" "0.933" "0.950" "0.952" "0.987" "0.980" "4861.2" "4846.0" "4746.4" "4813.1" "4711.8" "4535.7" "4617.6" "4627.2" "4799.3" "4766.0" "" "" "" "" "" "" "" "" "" "" "3904.4" "3496.7" "3770.2" "3224.8" "3258.7" "3403.0" "3233.0" "3379.2" "4799.3" "3875.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3718906404474103384" "False" "High" "IsMasterProtein" "P19174" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1" "0.000" "False" "135.594" "24" "25" "38" "25" "1290" "148.4" "6.05" "131.08" "25" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388" "5335" "ENSG00000124181" "PLCG1" "B7ZLY7; B9EGH4; E1P5W4; hsa:5335; P19174; Q2V575" "ISG15 antiviral mechanism; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Generation of second messenger molecules; Signaling by ALK fusions and activated point mutants; RET signaling; Downstream signal transduction; Signaling by ALK; DAP12 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; EGFR interacts with phospholipase C-gamma; Signaling by FGFR1 in disease; Synthesis of IP3 and IP4 in the cytosol; Phospholipase C-mediated cascade: FGFR1; Phospholipase C-mediated cascade; FGFR2; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Phospholipase C-mediated cascade; FGFR3; Phospholipase C-mediated cascade; FGFR4; Signaling by FGFR3 in disease; DAG and IP3 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Role of second messengers in netrin-1 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; PLC-gamma1 signalling; PECAM1 interactions; Activated NTRK2 signals through PLCG1; Activated NTRK3 signals through PLCG1" "Angiogenesis; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; PDGF pathway; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; GPR40 pathway; PDGFR-beta pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-small cell lung cancer; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway; T-cell receptor signaling pathway" "76" "0" "1.016" "0.991" "0.982" "1.027" "0.984" "0.990" "1.047" "1.015" "1.006" "2582.0" "2622.8" "2558.9" "2536.3" "2652.0" "2540.8" "2555.9" "2704.2" "2620.3" "2596.3" "" "" "" "" "" "" "" "" "" "" "2073.8" "1892.6" "2032.6" "1699.3" "1834.2" "1906.4" "1789.5" "1974.9" "2620.3" "2111.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117017983706301691" "False" "High" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "0.000" "False" "135.356" "66" "14" "138" "8" "245" "27.7" "4.78" "360.06" "14" "signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "19" "0" "1.009" "1.037" "0.950" "0.944" "0.999" "1.013" "1.002" "1.014" "0.994" "2016.6" "2034.9" "2090.6" "1915.7" "1904.3" "2014.1" "2042.1" "2019.7" "2044.3" "2005.4" "" "" "" "" "" "" "" "" "" "" "1619.7" "1468.3" "1660.7" "1283.5" "1317.0" "1511.1" "1429.7" "1475.0" "2044.3" "1630.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6253369152743795153" "False" "High" "IsMasterProtein" "Q8TD16" "Protein bicaudal D homolog 2 OS=Homo sapiens OX=9606 GN=BICD2 PE=1 SV=1" "0.000" "False" "135.101" "37" "27" "40" "25" "824" "93.5" "5.44" "132.46" "27" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf09730" "23299" "ENSG00000185963" "BICD2" "hsa:23299; O75181; Q5TBQ2; Q5TBQ3; Q8TD16; Q96LH2; Q9BT84; Q9H561" "COPI-independent Golgi-to-ER retrograde traffic" "" "1" "1" "1.004" "0.978" "0.984" "1.053" "1.025" "1.017" "1.012" "1.067" "1.005" "1986.1" "1993.9" "1941.9" "1955.3" "2090.7" "2035.7" "2019.2" "2009.5" "2119.5" "1996.3" "" "" "" "" "" "" "" "" "" "" "1595.2" "1438.7" "1542.5" "1310.1" "1446.0" "1527.4" "1413.8" "1467.5" "2119.5" "1623.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751284344252295029" "False" "High" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "0.000" "False" "135.061" "42" "11" "64" "11" "294" "32.6" "4.78" "247.00" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1-host interactions" "" "10" "0" "1.092" "1.264" "1.127" "1.046" "1.092" "1.102" "1.158" "1.054" "1.095" "4294.8" "4689.1" "5427.9" "4839.4" "4494.4" "4691.3" "4730.8" "4971.6" "4524.9" "4704.5" "" "" "" "" "" "" "" "" "" "" "3449.5" "3383.5" "4311.5" "3242.4" "3108.3" "3519.8" "3312.2" "3630.8" "4524.9" "3825.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338610440228744590" "False" "High" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "0.000" "False" "135.023" "28" "27" "46" "19" "913" "103.9" "7.37" "155.05" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "0" "0.983" "1.008" "0.940" "0.948" "0.960" "0.914" "1.014" "0.997" "0.969" "3945.0" "3878.4" "3976.3" "3710.0" "3739.3" "3785.4" "3605.1" "4001.7" "3931.5" "3821.7" "" "" "" "" "" "" "" "" "" "" "3168.6" "2798.6" "3158.5" "2485.7" "2586.1" "2840.1" "2524.1" "2922.5" "3931.5" "3107.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4060364465058462245" "False" "High" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "0.000" "False" "134.963" "53" "16" "45" "16" "360" "41.5" "4.91" "145.76" "16" "other biological processes" "other cell component" "enzyme regulator activity" "Pf12799, Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "" "2q37 copy number variation syndrome" "1" "0" "0.952" "0.934" "0.954" "0.959" "0.949" "0.925" "0.932" "0.953" "0.966" "2493.9" "2373.6" "2330.0" "2379.5" "2391.2" "2366.2" "2307.4" "2323.7" "2377.3" "2409.2" "" "" "" "" "" "" "" "" "" "" "2003.1" "1712.7" "1850.8" "1594.2" "1653.8" "1775.3" "1615.5" "1697.0" "2377.3" "1959.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968571585111953171" "False" "High" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "0.000" "False" "134.942" "38" "10" "29" "10" "377" "40.7" "4.79" "112.65" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Ub-specific processing proteases; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "64" "0" "0.999" "0.994" "1.019" "1.021" "0.977" "1.033" "0.994" "0.989" "0.972" "3093.9" "3091.6" "3076.2" "3153.8" "3158.9" "3021.3" "3196.9" "3074.6" "3059.0" "3005.8" "" "" "" "" "" "" "" "" "" "" "2485.0" "2230.8" "2443.5" "2113.1" "2184.7" "2266.8" "2238.3" "2245.4" "3059.0" "2444.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476906646827946246" "False" "High" "IsMasterProtein" "Q13315" "Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4" "0.000" "False" "134.888" "11" "29" "33" "29" "3056" "350.5" "6.81" "113.36" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf11640" "472" "ENSG00000149311" "ATM" "B2RNX5; hsa:472; O15429; Q12758; Q13315; Q16551; Q93007; Q9NP02; Q9UCX7" "Autodegradation of the E3 ubiquitin ligase COP1; TP53 Regulates Transcription of DNA Repair Genes; Regulation of HSF1-mediated heat shock response; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks; Pexophagy" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Homologous recombination; Glioblastoma signaling pathways; ATM signaling pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian infertility; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; ATM signaling in development and disease ; DNA IR-double strand breaks and cellular response via ATM; miRNA regulation of p53 pathway in prostate cancer; DNA IR-damage and cellular response via ATR; Breast cancer pathway; G1 to S cell cycle control; Joubert syndrome; Male infertility; DNA repair pathways, full network; Pleural mesothelioma; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome; Primary ovarian insufficiency; DNA damage response; DNA damage response (only ATM dependent)" "54" "0" "1.013" "1.040" "1.034" "1.024" "1.042" "1.029" "0.990" "0.995" "1.036" "1853.9" "1878.5" "1927.6" "1917.2" "1898.4" "1932.0" "1907.5" "1836.2" "1845.3" "1921.0" "" "" "" "" "" "" "" "" "" "" "1489.0" "1355.5" "1531.2" "1284.5" "1312.9" "1449.5" "1335.6" "1341.0" "1845.3" "1562.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174373993236338878" "False" "High" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "0.000" "False" "134.871" "38" "20" "78" "18" "471" "54.2" "8.95" "195.68" "20" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "" "mRNA processing" "1" "0" "1.038" "1.015" "1.017" "1.031" "1.027" "1.024" "1.010" "1.014" "1.017" "5062.4" "5253.1" "5138.4" "5150.3" "5221.9" "5199.7" "5185.3" "5111.0" "5133.9" "5148.2" "" "" "" "" "" "" "" "" "" "" "4066.1" "3790.5" "4081.6" "3450.7" "3611.5" "3901.2" "3630.5" "3732.5" "5133.9" "4186.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2017615054723730630" "False" "High" "IsMasterProtein" "Q6N069" "N-alpha-acetyltransferase 16, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA16 PE=1 SV=2" "0.000" "False" "134.727" "27" "24" "43" "18" "864" "101.4" "7.87" "144.85" "24" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf07719, Pf12569" "79612" "ENSG00000172766" "NAA16" "B0QZ59; hsa:79612; Q5VSP9; Q6N069; Q6P2D5; Q8N5J3; Q8N870" "" "" "0" "0" "1.018" "1.016" "0.996" "1.021" "1.047" "0.978" "1.025" "1.034" "1.033" "3344.9" "3406.7" "3397.2" "3333.2" "3413.6" "3501.2" "3270.4" "3427.2" "3460.0" "3456.5" "" "" "" "" "" "" "" "" "" "" "2686.6" "2458.2" "2698.5" "2233.3" "2360.9" "2626.9" "2289.7" "2502.9" "3460.0" "2810.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5545156882891984968" "False" "High" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "0.000" "False" "134.686" "45" "16" "37" "16" "510" "54.6" "8.76" "134.96" "16" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "1.007" "1.001" "1.016" "1.006" "1.014" "0.976" "1.055" "0.979" "1.042" "2644.1" "2662.5" "2645.7" "2687.3" "2659.9" "2680.5" "2580.0" "2788.9" "2588.8" "2754.3" "" "" "" "" "" "" "" "" "" "" "2123.7" "1921.2" "2101.6" "1800.5" "1839.6" "2011.1" "1806.4" "2036.8" "2588.8" "2239.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577661902964436810" "False" "High" "IsMasterProtein" "Q3LXA3" "Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2" "0.000" "False" "134.565" "41" "16" "31" "16" "575" "58.9" "7.49" "117.68" "16" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf02733, Pf02734" "26007" "ENSG00000149476" "TKFC" "hsa:26007; Q2L9C1; Q3LXA3; Q53EQ9; Q9BVA7; Q9H895" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; Fructose catabolism" "Novel intracellular components of RIG-I-like receptor pathway" "5" "0" "0.997" "0.957" "1.016" "0.990" "0.963" "0.988" "1.004" "0.940" "0.968" "2409.3" "2402.9" "2306.8" "2449.1" "2385.1" "2319.0" "2380.9" "2419.4" "2264.6" "2331.7" "" "" "" "" "" "" "" "" "" "" "1935.1" "1733.9" "1832.4" "1640.9" "1649.5" "1739.9" "1667.0" "1766.9" "2264.6" "1896.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2176751849839475967" "False" "High" "IsMasterProtein" "P14598" "Neutrophil cytosol factor 1 OS=Homo sapiens OX=9606 GN=NCF1 PE=1 SV=4" "0.000" "False" "134.393" "48" "16" "41" "16" "390" "44.7" "9.13" "152.44" "16" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf08944, Pf16621" "653361" "ENSG00000158517" "NCF1" "A6NEH2; A8K7S9; hsa:653361; O43842; P14598; Q2PP07; Q53FR5; Q9BU90; Q9BXI7; Q9BXI8; Q9UDV9; Q9UMU2" "VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Detoxification of Reactive Oxygen Species; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; IL-18 signaling pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "16" "0" "0.982" "0.999" "0.943" "0.951" "0.943" "0.891" "0.902" "0.905" "0.958" "3756.7" "3688.8" "3754.7" "3541.6" "3574.3" "3543.7" "3346.4" "3388.0" "3398.3" "3597.8" "" "" "" "" "" "" "" "" "" "" "3017.3" "2661.8" "2982.5" "2372.9" "2472.0" "2658.7" "2343.0" "2474.2" "3398.3" "2925.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3011469150095823870" "False" "High" "IsMasterProtein" "Q9Y696" "Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4" "0.000" "False" "134.288" "57" "12" "27" "12" "253" "28.8" "5.59" "104.31" "12" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409" "25932" "ENSG00000169504" "CLIC4" "hsa:25932; Q9UFW9; Q9UQJ6; Q9Y696" "" "" "0" "0" "0.963" "0.965" "0.917" "0.956" "1.000" "0.978" "0.904" "0.967" "0.926" "2911.8" "2804.0" "2810.5" "2669.4" "2785.1" "2911.3" "2846.5" "2631.1" "2816.2" "2697.5" "" "" "" "" "" "" "" "" "" "" "2338.8" "2023.3" "2232.5" "1788.5" "1926.2" "2184.3" "1993.0" "1921.5" "2816.2" "2193.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "556799029181218119" "False" "High" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "0.000" "False" "134.202" "30" "14" "28" "12" "522" "59.0" "5.15" "102.62" "14" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "0" "1.025" "1.011" "0.993" "0.974" "0.980" "0.934" "0.951" "0.967" "1.015" "1926.7" "1974.4" "1947.4" "1913.6" "1875.9" "1887.8" "1798.6" "1833.0" "1862.3" "1954.9" "" "" "" "" "" "" "" "" "" "" "1547.5" "1424.7" "1546.8" "1282.1" "1297.4" "1416.4" "1259.3" "1338.7" "1862.3" "1589.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211102690049465357" "False" "High" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "0.000" "False" "133.810" "37" "15" "62" "15" "421" "46.6" "8.37" "221.95" "15" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "13" "0" "0.949" "1.001" "0.910" "0.916" "0.934" "0.873" "0.898" "0.931" "0.923" "5621.1" "5334.0" "5629.2" "5114.3" "5150.0" "5251.5" "4908.5" "5046.7" "5230.6" "5187.3" "" "" "" "" "" "" "" "" "" "" "4514.8" "3848.9" "4471.4" "3426.6" "3561.8" "3940.1" "3436.7" "3685.6" "5230.6" "4218.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3705631994362769923" "False" "High" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "0.000" "False" "133.756" "52" "23" "40" "23" "515" "59.2" "6.84" "132.71" "23" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "16" "0" "0.980" "0.997" "0.932" "0.990" "0.965" "0.978" "0.979" "1.052" "0.989" "3653.6" "3579.3" "3643.1" "3403.3" "3616.9" "3525.2" "3572.1" "3576.5" "3843.0" "3611.8" "" "" "" "" "" "" "" "" "" "" "2934.5" "2582.7" "2893.8" "2280.2" "2501.5" "2644.9" "2501.0" "2611.9" "3843.0" "2937.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8769135798573244061" "False" "High" "IsMasterProtein" "P35658" "Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2" "0.000" "False" "133.581" "13" "23" "33" "23" "2090" "213.5" "7.47" "122.33" "23" "other metabolic processes;transport;other biological processes" "cytosol;nucleus" "other molecular function" "Pf18617" "8021" "ENSG00000126883" "NUP214" "A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HuR (ELAVL1) binds and stabilizes mRNA" "TGF-beta signaling pathway" "30" "0" "1.027" "0.986" "1.003" "1.047" "1.027" "1.017" "1.087" "1.086" "1.036" "3036.4" "3118.4" "2994.3" "3044.8" "3179.5" "3117.4" "3088.1" "3301.0" "3297.4" "3147.2" "" "" "" "" "" "" "" "" "" "" "2438.8" "2250.2" "2378.5" "2040.0" "2198.9" "2338.9" "2162.1" "2410.7" "3297.4" "2559.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7263541365096533312" "False" "High" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "0.000" "False" "133.552" "29" "23" "46" "23" "895" "100.2" "5.67" "157.99" "23" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "0.992" "1.029" "1.014" "0.983" "0.997" "1.036" "1.019" "1.017" "1.013" "4752.3" "4714.9" "4890.6" "4819.1" "4671.8" "4740.2" "4921.8" "4840.6" "4833.8" "4812.5" "" "" "" "" "" "" "" "" "" "" "3817.0" "3402.2" "3884.7" "3228.8" "3231.1" "3556.5" "3446.0" "3535.1" "4833.8" "3913.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137666002023082164" "False" "High" "IsMasterProtein" "Cont_P00761" "Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1" "0.000" "True" "133.417" "56" "10" "183" "9" "231" "24.4" "7.18" "564.92" "10" "protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "" "" "" "" "" "" "0" "1" "1.020" "1.007" "1.132" "1.142" "1.071" "1.088" "1.120" "1.039" "1.065" "11148.6" "11374.1" "11224.1" "12619.1" "12727.5" "11938.6" "12127.7" "12484.5" "11582.7" "11867.8" "" "" "" "" "" "" "" "" "" "" "8954.4" "8207.3" "8915.6" "8454.8" "8802.4" "8957.3" "8491.2" "9117.5" "11582.7" "9651.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "152076562272560972" "False" "High" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "0.000" "False" "133.162" "29" "12" "38" "12" "638" "71.4" "5.20" "140.27" "12" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380; ENSG00000292102" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "23" "0" "1.041" "1.048" "1.107" "1.065" "1.010" "1.067" "1.040" "1.065" "1.048" "2727.8" "2840.4" "2859.9" "3020.0" "2904.2" "2755.9" "2911.8" "2835.9" "2905.6" "2858.0" "" "" "" "" "" "" "" "" "" "" "2190.9" "2049.6" "2271.7" "2023.4" "2008.6" "2067.7" "2038.7" "2071.1" "2905.6" "2324.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549742544018315320" "False" "High" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "0.000" "False" "132.891" "36" "19" "39" "19" "637" "72.6" "6.29" "133.55" "19" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "5" "0" "0.952" "1.004" "0.950" "0.972" "0.987" "0.916" "0.961" "0.948" "0.970" "4120.0" "3923.9" "4135.5" "3915.6" "4005.0" "4067.8" "3772.7" "3959.3" "3907.6" "3995.1" "" "" "" "" "" "" "" "" "" "" "3309.1" "2831.4" "3284.9" "2623.5" "2769.9" "3052.0" "2641.4" "2891.5" "3907.6" "3249.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5541205227018029514" "False" "High" "IsMasterProtein" "Q9H0P0" "Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3" "0.000" "False" "132.852" "55" "18" "50" "18" "336" "37.9" "7.12" "144.45" "18" "other metabolic processes;stress response" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05822" "51251" "ENSG00000122643" "NT5C3A" "A8K253; B2RAA5; B8ZZC4; hsa:51251; Q6IPZ1; Q6NXS6; Q7L3G6; Q9H0P0; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45" "" "" "0" "0" "0.953" "0.994" "0.974" "1.016" "1.007" "1.028" "0.994" "1.002" "1.002" "4113.0" "3921.3" "4088.9" "4005.3" "4177.4" "4141.0" "4226.6" "4088.3" "4120.3" "4119.4" "" "" "" "" "" "" "" "" "" "" "3303.5" "2829.5" "3247.9" "2683.6" "2889.1" "3106.9" "2959.3" "2985.7" "4120.3" "3350.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174842833444890787" "False" "High" "IsMasterProtein" "Q99613" "Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1" "0.000" "False" "132.807" "30" "27" "39" "26" "913" "105.3" "5.68" "123.13" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "8663" "ENSG00000184110" "EIF3C" "A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "1" "0.968" "1.047" "1.051" "1.047" "1.063" "1.116" "1.068" "1.042" "1.064" "2764.0" "2675.4" "2893.2" "2905.6" "2894.9" "2939.3" "3085.7" "2953.0" "2879.0" "2939.6" "" "" "" "" "" "" "" "" "" "" "2220.0" "1930.5" "2298.2" "1946.8" "2002.2" "2205.3" "2160.5" "2156.6" "2879.0" "2390.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683899515612259900" "False" "High" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "0.000" "False" "132.665" "41" "25" "39" "22" "668" "75.0" "9.66" "122.36" "25" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in progeria" "7" "1" "1.022" "1.041" "1.037" "0.940" "0.952" "0.984" "1.032" "1.038" "1.002" "2089.1" "2135.0" "2174.3" "2167.0" "1963.3" "1989.4" "2055.3" "2156.0" "2169.1" "2093.4" "" "" "" "" "" "" "" "" "" "" "1677.9" "1540.6" "1727.1" "1451.9" "1357.9" "1492.6" "1439.0" "1574.6" "2169.1" "1702.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184092773991491015" "False" "High" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "0.000" "False" "132.591" "51" "15" "42" "14" "380" "42.6" "8.62" "140.19" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "Base excision repair; DNA repair pathways, full network" "8" "1" "1.040" "0.991" "0.998" "0.993" "0.960" "1.043" "1.039" "1.055" "1.016" "2266.0" "2356.0" "2245.9" "2261.7" "2251.2" "2175.0" "2364.4" "2355.2" "2391.6" "2301.7" "" "" "" "" "" "" "" "" "" "" "1820.0" "1700.1" "1784.0" "1515.3" "1556.9" "1631.9" "1655.4" "1720.0" "2391.6" "1871.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5053375512568543969" "False" "High" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "0.000" "False" "131.390" "49" "21" "34" "21" "509" "54.8" "5.59" "104.86" "21" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Regulation of HSF1-mediated heat shock response" "Parkin-ubiquitin proteasomal system pathway" "2" "0" "0.965" "0.962" "0.969" "0.960" "0.990" "0.988" "0.986" "1.002" "0.939" "1881.1" "1815.5" "1809.9" "1822.2" "1805.9" "1862.6" "1857.6" "1854.9" "1884.4" "1765.8" "" "" "" "" "" "" "" "" "" "" "1510.9" "1310.0" "1437.6" "1220.9" "1249.0" "1397.5" "1300.6" "1354.6" "1884.4" "1436.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8282495750123490209" "False" "High" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "0.000" "False" "131.296" "36" "23" "56" "16" "644" "67.5" "7.61" "167.85" "23" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "1" "1.048" "1.039" "1.029" "1.001" "0.987" "0.978" "1.010" "0.998" "0.990" "3888.3" "4075.0" "4041.2" "4001.5" "3890.4" "3838.7" "3801.7" "3928.0" "3880.1" "3848.3" "" "" "" "" "" "" "" "" "" "" "3123.0" "2940.4" "3210.0" "2681.0" "2690.7" "2880.1" "2661.7" "2868.6" "3880.1" "3129.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516954531369469772" "False" "High" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "0.000" "False" "130.859" "58" "14" "58" "14" "246" "27.4" "6.76" "202.04" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "UCH proteinases; Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.945" "0.998" "0.903" "0.959" "1.021" "0.980" "0.975" "0.951" "0.964" "4810.1" "4547.1" "4799.2" "4344.1" "4613.5" "4909.1" "4712.3" "4688.6" "4575.4" "4639.0" "" "" "" "" "" "" "" "" "" "" "3863.4" "3281.1" "3812.2" "2910.6" "3190.8" "3683.2" "3299.3" "3424.1" "4575.4" "3772.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5554010069989842743" "False" "High" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "0.000" "False" "130.507" "42" "17" "37" "17" "524" "59.0" "7.34" "129.78" "17" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "0.990" "1.008" "0.934" "0.965" "0.963" "0.946" "1.020" "1.061" "1.005" "3069.8" "3038.7" "3095.8" "2867.8" "2963.7" "2956.9" "2902.7" "3129.7" "3256.2" "3085.5" "" "" "" "" "" "" "" "" "" "" "2465.6" "2192.6" "2459.1" "1921.4" "2049.7" "2218.5" "2032.3" "2285.7" "3256.2" "2509.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4997024104720897707" "False" "High" "IsMasterProtein" "Q9BZK7" "F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1" "0.000" "False" "130.457" "45" "15" "29" "15" "514" "55.6" "5.55" "113.85" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "79718" "ENSG00000177565" "TBL1XR1" "D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1" "HCMV Early Events; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "Rett syndrome" "20" "0" "0.986" "1.008" "1.008" "0.987" "0.989" "0.961" "0.980" "0.924" "0.972" "2615.1" "2578.5" "2635.7" "2637.0" "2580.4" "2586.6" "2512.3" "2561.7" "2416.6" "2541.9" "" "" "" "" "" "" "" "" "" "" "2100.4" "1860.6" "2093.6" "1766.8" "1784.6" "1940.7" "1759.0" "1870.8" "2416.6" "2067.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7100532501288988865" "False" "High" "IsMasterProtein" "P55795" "Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1" "0.000" "False" "130.183" "41" "14" "41" "5" "449" "49.2" "6.30" "119.95" "14" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00076, Pf08080" "3188" "ENSG00000126945" "HNRNPH2" "A1L400; P55795; Q9HHA7" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "1.092" "1.097" "1.115" "1.084" "1.005" "1.063" "1.057" "1.114" "1.061" "718.0" "784.3" "787.7" "800.8" "778.3" "721.8" "763.3" "758.8" "799.6" "761.7" "" "" "" "" "" "" "" "" "" "" "576.7" "565.9" "625.7" "536.5" "538.3" "541.6" "534.4" "554.1" "799.6" "619.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6180366262275080504" "False" "High" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "0.000" "False" "130.104" "39" "17" "58" "17" "430" "47.5" "9.01" "181.29" "17" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "11" "0" "0.994" "0.989" "0.948" "0.916" "0.962" "0.857" "0.822" "0.890" "0.920" "5196.1" "5166.3" "5138.6" "4924.7" "4759.1" "5000.7" "4452.3" "4268.6" "4624.3" "4778.0" "" "" "" "" "" "" "" "" "" "" "4173.5" "3727.9" "4081.8" "3299.6" "3291.4" "3751.9" "3117.3" "3117.4" "4624.3" "3885.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1343514979661683430" "False" "High" "IsMasterProtein" "P22234" "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "0.000" "False" "130.007" "38" "17" "58" "17" "425" "47.0" "7.23" "189.70" "17" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Purine ribonucleoside monophosphate biosynthesis" "Metabolic reprogramming in colon cancer" "2" "0" "0.984" "1.043" "1.002" "0.992" "0.985" "0.994" "0.955" "0.940" "0.957" "5245.0" "5161.5" "5469.1" "5253.1" "5205.2" "5166.6" "5214.3" "5011.4" "4928.5" "5021.9" "" "" "" "" "" "" "" "" "" "" "4212.7" "3724.4" "4344.3" "3519.6" "3600.0" "3876.4" "3650.8" "3659.9" "4928.5" "4084.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667668452715930583" "False" "High" "IsMasterProtein" "O60264" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1" "0.000" "False" "129.969" "25" "26" "33" "26" "1052" "121.8" "8.09" "114.42" "26" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "8467" "ENSG00000153147" "SMARCA5" "hsa:8467; O60264" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression" "10q11.21q11.23 copy number variation syndrome" "5" "0" "1.008" "1.074" "1.049" "0.995" "1.007" "1.046" "1.131" "1.103" "1.048" "3297.9" "3323.8" "3541.6" "3459.3" "3282.4" "3319.4" "3450.0" "3730.5" "3638.0" "3454.6" "" "" "" "" "" "" "" "" "" "" "2648.8" "2398.4" "2813.2" "2317.7" "2270.1" "2490.5" "2415.5" "2724.4" "3638.0" "2809.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "170444545631699205" "False" "High" "IsMasterProtein" "Q9Y4E1" "WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=5" "0.000" "False" "129.698" "18" "18" "25" "3" "1341" "147.1" "4.81" "93.44" "18" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "253725" "ENSG00000172661" "WASHC2C" "A0A096LPC5; B4DZQ6; B9EK53; F5H0J6; F5H871; hsa:253725; Q5SQU4; Q5SQU5; Q7L521; Q9UG79; Q9Y4E1" "" "" "0" "10" "1.027" "0.981" "1.044" "1.027" "0.927" "0.945" "0.998" "0.990" "0.981" "1653.1" "1698.0" "1621.1" "1725.2" "1697.5" "1532.8" "1563.0" "1650.0" "1636.8" "1621.1" "" "" "" "" "" "" "" "" "" "" "1327.8" "1225.3" "1287.7" "1155.9" "1174.0" "1150.0" "1094.3" "1205.0" "1636.8" "1318.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3527140061799616806" "False" "High" "IsMasterProtein" "Q9BW19" "Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2" "0.000" "False" "129.544" "36" "21" "28" "21" "673" "73.7" "8.98" "100.18" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf00225" "3833" "ENSG00000204197; ENSG00000233450; ENSG00000237649" "KIFC1" "hsa:3833; O60887; Q14834; Q4KMP0; Q5SU09; Q6GMS7; Q6P4A5; Q9BW19; Q9UQP7" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "" "2" "0" "1.031" "1.036" "1.080" "1.061" "0.967" "1.203" "1.239" "1.210" "1.085" "1520.9" "1568.3" "1575.9" "1642.2" "1613.3" "1470.4" "1829.8" "1884.7" "1840.9" "1649.9" "" "" "" "" "" "" "" "" "" "" "1221.6" "1131.7" "1251.8" "1100.2" "1115.8" "1103.2" "1281.1" "1376.4" "1840.9" "1341.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902692244369353681" "False" "High" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "0.000" "False" "129.372" "44" "19" "31" "19" "523" "56.5" "6.42" "120.23" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "MHC class II antigen presentation; RHO GTPases Activate Formins; HCMV Early Events; Separation of Sister Chromatids; Neutrophil degranulation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "16" "0" "1.011" "0.997" "1.002" "0.999" "1.004" "1.018" "1.004" "1.009" "1.019" "3914.7" "3959.2" "3901.0" "3921.8" "3910.7" "3930.7" "3986.9" "3931.0" "3949.9" "3988.2" "" "" "" "" "" "" "" "" "" "" "3144.2" "2856.8" "3098.7" "2627.6" "2704.7" "2949.1" "2791.4" "2870.8" "3949.9" "3243.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366486650245995426" "False" "High" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "0.000" "False" "129.084" "32" "17" "35" "17" "647" "69.0" "7.84" "117.55" "17" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "8" "0" "0.979" "0.929" "0.934" "0.957" "0.936" "0.950" "0.936" "0.933" "0.930" "3822.1" "3740.6" "3551.0" "3571.1" "3656.1" "3576.9" "3632.7" "3577.3" "3565.6" "3554.6" "" "" "" "" "" "" "" "" "" "" "3069.8" "2699.1" "2820.6" "2392.6" "2528.6" "2683.7" "2543.5" "2612.5" "3565.6" "2890.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6826541305752528518" "False" "High" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "0.000" "False" "128.570" "37" "14" "36" "14" "471" "53.1" "6.23" "127.07" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Cytosolic tRNA aminoacylation" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "3" "0" "0.963" "1.026" "0.913" "0.965" "1.075" "0.905" "0.955" "0.952" "0.989" "2462.3" "2370.6" "2526.2" "2248.7" "2376.6" "2647.9" "2229.0" "2350.3" "2344.1" "2435.2" "" "" "" "" "" "" "" "" "" "" "1977.7" "1710.6" "2006.6" "1506.6" "1643.7" "1986.7" "1560.7" "1716.5" "2344.1" "1980.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6973365880698085835" "False" "High" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "0.000" "False" "128.542" "35" "20" "53" "20" "586" "65.4" "8.97" "185.15" "20" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "1.002" "0.984" "1.008" "0.949" "0.960" "0.959" "0.947" "0.936" "0.976" "4597.3" "4607.3" "4526.0" "4633.7" "4361.0" "4414.5" "4410.9" "4354.8" "4301.7" "4486.8" "" "" "" "" "" "" "" "" "" "" "3692.5" "3324.5" "3595.1" "3104.6" "3016.1" "3312.1" "3088.3" "3180.3" "4301.7" "3648.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286637805257654056" "False" "High" "IsMasterProtein" "Q9BQG0" "Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2" "0.000" "False" "128.178" "20" "23" "36" "23" "1328" "148.8" "9.28" "118.83" "23" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04931" "10514" "ENSG00000132382" "MYBBP1A" "hsa:10514; Q86VM3; Q9BQG0; Q9BW49; Q9P0V5; Q9UF99" "B-WICH complex positively regulates rRNA expression" "Energy metabolism; 10q11.21q11.23 copy number variation syndrome" "3" "0" "1.125" "1.098" "1.117" "1.114" "1.055" "1.056" "1.100" "1.042" "1.109" "1800.5" "2025.4" "1977.5" "2010.4" "2005.0" "1898.7" "1900.9" "1980.5" "1876.5" "1997.1" "" "" "" "" "" "" "" "" "" "" "1446.1" "1461.5" "1570.8" "1347.0" "1386.7" "1424.6" "1330.9" "1446.3" "1876.5" "1624.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986296192720168781" "False" "High" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "0.000" "False" "128.084" "46" "15" "37" "14" "370" "40.4" "7.66" "137.81" "15" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "7" "0" "0.965" "0.956" "0.906" "0.961" "0.997" "0.940" "0.931" "0.903" "0.916" "4744.5" "4580.7" "4537.5" "4297.7" "4560.8" "4731.7" "4457.7" "4416.8" "4284.2" "4343.8" "" "" "" "" "" "" "" "" "" "" "3810.8" "3305.3" "3604.2" "2879.5" "3154.3" "3550.1" "3121.0" "3225.6" "4284.2" "3532.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4801012359298608333" "False" "High" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "0.000" "False" "127.397" "29" "14" "26" "14" "609" "67.3" "6.57" "95.85" "14" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372, Pf21171" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "OAS antiviral response" "Phosphodiesterases in neuronal function" "2" "0" "1.031" "1.005" "1.001" "1.020" "0.995" "1.002" "0.975" "0.968" "0.992" "1143.2" "1178.8" "1149.2" "1143.8" "1166.5" "1137.7" "1145.1" "1114.3" "1106.2" "1133.8" "" "" "" "" "" "" "" "" "" "" "918.2" "850.6" "912.8" "766.4" "806.8" "853.6" "801.7" "813.8" "1106.2" "922.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4468909642596951639" "False" "High" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "0.000" "False" "127.066" "27" "26" "42" "26" "963" "109.9" "5.57" "133.84" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "1.054" "1.050" "1.051" "1.000" "1.009" "0.969" "1.067" "1.027" "1.044" "3393.4" "3578.1" "3561.5" "3567.5" "3393.8" "3423.9" "3287.8" "3620.5" "3485.2" "3543.8" "" "" "" "" "" "" "" "" "" "" "2725.5" "2581.8" "2829.0" "2390.2" "2347.2" "2568.9" "2301.9" "2644.1" "3485.2" "2881.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1887782222287180929" "False" "High" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "0.000" "False" "127.033" "36" "21" "39" "20" "474" "53.2" "7.08" "129.07" "21" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "0.979" "1.040" "1.051" "1.000" "1.075" "1.113" "1.033" "0.863" "1.016" "4748.8" "4651.3" "4939.1" "4991.2" "4747.4" "5103.2" "5285.1" "4904.7" "4098.1" "4825.8" "" "" "" "" "" "" "" "" "" "" "3814.2" "3356.3" "3923.3" "3344.1" "3283.4" "3828.8" "3700.4" "3581.9" "4098.1" "3924.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2867565850229162791" "False" "High" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "0.000" "False" "126.641" "39" "20" "39" "20" "509" "57.4" "5.88" "134.16" "20" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Cytosolic tRNA aminoacylation" "Allograft rejection" "2" "0" "0.991" "0.991" "1.021" "0.995" "0.965" "0.982" "0.998" "0.966" "0.990" "4732.5" "4690.2" "4689.8" "4831.3" "4707.4" "4567.8" "4649.2" "4722.8" "4571.4" "4685.3" "" "" "" "" "" "" "" "" "" "" "3801.1" "3384.3" "3725.2" "3237.0" "3255.7" "3427.2" "3255.1" "3449.0" "4571.4" "3810.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8154313858001218704" "False" "High" "IsMasterProtein" "Q8IWZ3" "Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1" "0.000" "False" "126.623" "15" "29" "36" "18" "2542" "269.3" "5.73" "102.84" "29" "stress response" "other cell component" "" "Pf00013, Pf12796, Pf13637" "404734; 54882" "ENSG00000131503" "ANKHD1" "A6NH85; hsa:404734; hsa:54882; Q149P2; Q8IWZ2; Q8IWZ3; Q8WY90; Q96G77; Q96GK0; Q9H2U0; Q9HA95; Q9NWG4; Q9UPR7" "" "" "0" "7" "1.044" "1.012" "1.063" "1.017" "0.990" "1.057" "1.069" "1.088" "1.046" "1403.6" "1465.5" "1419.8" "1492.2" "1427.4" "1389.5" "1483.7" "1500.0" "1527.5" "1468.4" "" "" "" "" "" "" "" "" "" "" "1127.3" "1057.5" "1127.8" "999.8" "987.2" "1042.5" "1038.8" "1095.5" "1527.5" "1194.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "565785606400917725" "False" "High" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "0.000" "False" "126.468" "32" "23" "40" "22" "723" "83.4" "6.67" "133.23" "23" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "Cytosolic tRNA aminoacylation" "" "1" "1" "0.952" "0.976" "0.957" "0.957" "0.980" "0.982" "0.953" "0.950" "0.979" "4514.8" "4299.2" "4408.3" "4320.5" "4322.4" "4423.1" "4433.9" "4301.1" "4286.9" "4418.9" "" "" "" "" "" "" "" "" "" "" "3626.2" "3102.2" "3501.7" "2894.7" "2989.4" "3318.6" "3104.4" "3141.1" "4286.9" "3593.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3931502688338012469" "False" "High" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "0.000" "False" "126.372" "50" "14" "31" "14" "363" "39.7" "8.02" "116.79" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "1.055" "1.020" "1.034" "0.991" "0.975" "0.990" "1.114" "1.033" "1.008" "2647.4" "2793.3" "2699.0" "2738.6" "2624.7" "2581.2" "2622.2" "2948.9" "2735.4" "2669.0" "" "" "" "" "" "" "" "" "" "" "2126.4" "2015.5" "2143.9" "1834.9" "1815.3" "1936.6" "1835.9" "2153.6" "2735.4" "2170.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697106387219567458" "False" "High" "IsMasterProtein" "Q6P2E9" "Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1" "0.000" "False" "126.256" "21" "22" "33" "22" "1401" "151.6" "5.86" "107.37" "22" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf16529, Pf21289" "23644" "ENSG00000038358" "EDC4" "A6NGM1; A8K4T4; hsa:23644; Q13025; Q13826; Q6P2E9; Q6ZR12; Q7Z6H7" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.053" "1.018" "1.080" "1.078" "1.069" "1.100" "1.035" "1.051" "1.042" "1497.0" "1576.0" "1523.7" "1617.2" "1614.3" "1600.1" "1646.9" "1548.9" "1573.1" "1559.6" "" "" "" "" "" "" "" "" "" "" "1202.4" "1137.2" "1210.3" "1083.5" "1116.5" "1200.5" "1153.1" "1131.2" "1573.1" "1268.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845152794455651809" "False" "High" "IsMasterProtein" "O75179" "Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3" "0.000" "False" "126.198" "12" "24" "34" "13" "2603" "274.1" "6.52" "96.26" "24" "stress response;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00013, Pf12796, Pf13637" "26057" "ENSG00000132466" "ANKRD17" "E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9" "" "" "0" "0" "0.978" "0.943" "1.059" "1.029" "0.981" "1.001" "1.023" "0.988" "1.055" "875.5" "856.2" "825.7" "927.6" "901.3" "859.3" "876.8" "895.9" "865.2" "923.5" "" "" "" "" "" "" "" "" "" "" "703.2" "617.8" "655.8" "621.5" "623.4" "644.7" "613.9" "654.3" "865.2" "751.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7946497630754715310" "False" "High" "IsMasterProtein" "Q9H223" "EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1" "0.000" "False" "126.119" "39" "18" "37" "18" "541" "61.1" "6.76" "118.76" "18" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30844" "ENSG00000103966" "EHD4" "hsa:30844; Q9H223; Q9HAR1; Q9NZN2" "" "" "0" "0" "0.994" "0.962" "0.957" "0.938" "0.913" "0.962" "0.967" "1.014" "0.968" "3427.1" "3406.3" "3295.4" "3278.6" "3213.8" "3129.9" "3297.0" "3313.0" "3476.4" "3317.0" "" "" "" "" "" "" "" "" "" "" "2752.6" "2457.9" "2617.7" "2196.6" "2222.7" "2348.3" "2308.4" "2419.5" "3476.4" "2697.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5136159273712408888" "False" "High" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "0.000" "False" "126.068" "46" "18" "36" "15" "411" "46.8" "6.73" "130.43" "18" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543; ENSG00000291508" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "TAR syndrome" "11" "0" "0.996" "0.998" "0.997" "0.972" "1.000" "0.984" "1.019" "1.052" "1.013" "1654.0" "1647.2" "1650.8" "1648.8" "1608.0" "1654.6" "1628.3" "1684.7" "1740.7" "1675.5" "" "" "" "" "" "" "" "" "" "" "1328.5" "1188.6" "1311.3" "1104.7" "1112.1" "1241.4" "1140.0" "1230.3" "1740.7" "1362.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5250221047475229599" "False" "High" "IsMasterProtein" "Q7LBC6" "Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2" "0.000" "False" "126.030" "17" "26" "32" "24" "1761" "191.5" "7.18" "104.10" "26" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "51780" "ENSG00000120733" "KDM3B" "A6H8X7; hsa:51780; Q7LBC6; Q9BVH6; Q9BW93; Q9BZ52; Q9NYF4; Q9UPS0" "HDMs demethylate histones" "Thermogenesis" "2" "0" "0.968" "0.957" "0.979" "0.949" "0.949" "0.912" "0.945" "0.951" "0.960" "2114.8" "2046.6" "2023.6" "2071.0" "2007.0" "2006.0" "1929.5" "1998.7" "2010.5" "2030.0" "" "" "" "" "" "" "" "" "" "" "1698.6" "1476.7" "1607.4" "1387.6" "1388.1" "1505.1" "1351.0" "1459.6" "2010.5" "1650.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8732346175470674622" "False" "High" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "0.000" "False" "125.990" "24" "32" "40" "31" "1357" "156.2" "5.64" "128.80" "32" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOG GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RHO GTPases activate KTN1" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "11" "0" "0.975" "0.924" "0.959" "0.940" "0.967" "0.987" "0.971" "1.098" "0.962" "2470.9" "2409.3" "2282.2" "2370.1" "2323.6" "2389.5" "2439.5" "2399.8" "2712.1" "2377.0" "" "" "" "" "" "" "" "" "" "" "1984.6" "1738.5" "1812.8" "1588.0" "1607.1" "1792.8" "1708.0" "1752.6" "2712.1" "1933.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543503445909431130" "False" "High" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "0.000" "False" "125.919" "26" "15" "33" "15" "732" "81.2" "5.48" "114.94" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "Neutrophil degranulation; Eukaryotic Translation Termination" "" "2" "0" "0.980" "0.976" "0.965" "0.989" "0.990" "0.962" "0.943" "0.940" "0.963" "2483.0" "2432.5" "2424.3" "2395.6" "2454.8" "2458.6" "2388.3" "2341.9" "2333.4" "2391.7" "" "" "" "" "" "" "" "" "" "" "1994.3" "1755.3" "1925.7" "1605.0" "1697.8" "1844.6" "1672.2" "1710.3" "2333.4" "1945.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6317068778034787864" "False" "High" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "0.000" "False" "125.899" "34" "18" "28" "18" "642" "72.9" "5.87" "102.58" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "0.992" "0.994" "0.967" "0.991" "1.000" "1.062" "1.072" "1.041" "1.000" "2188.0" "2170.2" "2174.9" "2116.0" "2169.2" "2188.3" "2323.7" "2344.5" "2278.2" "2188.8" "" "" "" "" "" "" "" "" "" "" "1757.4" "1566.0" "1727.6" "1417.7" "1500.3" "1641.8" "1626.9" "1712.2" "2278.2" "1780.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1831156275587946455" "False" "High" "IsMasterProtein" "Q7Z401" "C-myc promoter-binding protein OS=Homo sapiens OX=9606 GN=DENND4A PE=1 SV=2" "0.000" "False" "125.821" "13" "22" "32" "22" "1863" "209.1" "7.31" "109.33" "22" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf02141, Pf03455, Pf03456" "10260" "ENSG00000174485" "DENND4A" "E7EPL3; hsa:10260; Q14655; Q7Z401; Q86T77; Q8IVX2; Q8NB93" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.051" "1.012" "1.045" "1.021" "0.971" "0.954" "1.027" "0.992" "1.036" "2614.4" "2748.9" "2645.6" "2732.0" "2670.4" "2538.1" "2494.5" "2685.9" "2594.5" "2708.5" "" "" "" "" "" "" "" "" "" "" "2099.9" "1983.6" "2101.4" "1830.4" "1846.9" "1904.3" "1746.5" "1961.5" "2594.5" "2202.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8479889696518381262" "False" "High" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "0.000" "False" "125.753" "70" "13" "91" "13" "199" "22.4" "8.25" "263.16" "13" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "Platelet degranulation" "" "1" "0" "1.029" "1.029" "1.052" "1.048" "1.025" "1.062" "1.043" "1.038" "1.040" "6470.9" "6656.8" "6660.8" "6804.8" "6781.0" "6634.7" "6873.2" "6751.2" "6716.9" "6728.5" "" "" "" "" "" "" "" "" "" "" "5197.4" "4803.4" "5290.9" "4559.2" "4689.8" "4977.9" "4812.3" "4930.4" "6716.9" "5471.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2629792950046784631" "False" "High" "IsMasterProtein" "Q12849" "G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3" "0.000" "False" "125.658" "46" "17" "31" "17" "480" "53.1" "6.19" "114.13" "17" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "2926" "ENSG00000132463" "GRSF1" "B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2" "Viral mRNA Translation; Mitochondrial RNA degradation" "VEGFA-VEGFR2 signaling" "3" "0" "0.946" "1.025" "0.913" "0.894" "0.983" "0.834" "0.875" "0.891" "0.930" "3405.8" "3220.3" "3490.1" "3109.8" "3045.0" "3347.3" "2839.1" "2978.7" "3033.1" "3166.5" "" "" "" "" "" "" "" "" "" "" "2735.5" "2323.6" "2772.3" "2083.6" "2105.9" "2511.4" "1987.8" "2175.3" "3033.1" "2575.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1371524125527115551" "False" "High" "IsMasterProtein" "Q9NZM3" "Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3" "0.000" "False" "125.586" "16" "28" "38" "28" "1697" "193.3" "8.12" "107.86" "28" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652" "50618" "ENSG00000198399" "ITSN2" "O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4" "Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle" "" "3" "0" "0.992" "0.962" "0.964" "0.996" "1.012" "0.969" "1.030" "1.035" "1.013" "4582.8" "4547.1" "4410.5" "4418.3" "4562.9" "4637.3" "4441.9" "4722.5" "4743.3" "4644.4" "" "" "" "" "" "" "" "" "" "" "3680.8" "3281.1" "3503.4" "2960.3" "3155.7" "3479.3" "3110.0" "3448.9" "4743.3" "3777.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468069501493151827" "False" "High" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "0.000" "False" "125.001" "43" "16" "58" "16" "337" "37.5" "6.81" "169.82" "16" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "9" "0" "0.971" "0.981" "0.975" "0.971" "0.981" "0.983" "0.968" "0.967" "0.970" "6557.5" "6370.3" "6432.0" "6392.0" "6367.0" "6434.8" "6448.4" "6348.2" "6340.3" "6358.8" "" "" "" "" "" "" "" "" "" "" "5266.9" "4596.6" "5109.1" "4282.6" "4403.5" "4827.9" "4514.9" "4636.1" "6340.3" "5171.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6930052097087835026" "False" "High" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "0.000" "False" "124.849" "25" "16" "24" "16" "741" "82.5" "5.06" "96.84" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "Condensation of Prometaphase Chromosomes" "2q11.2 copy number variation syndrome" "2" "0" "1.015" "0.986" "0.996" "1.010" "0.979" "0.945" "0.986" "0.975" "0.974" "2998.8" "3042.4" "2957.9" "2986.7" "3028.1" "2936.6" "2832.9" "2955.8" "2924.9" "2920.1" "" "" "" "" "" "" "" "" "" "" "2408.6" "2195.3" "2349.5" "2001.1" "2094.3" "2203.2" "1983.4" "2158.6" "2924.9" "2374.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8579706144891720478" "False" "High" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "0.000" "False" "124.661" "25" "22" "27" "22" "1087" "120.9" "5.06" "93.57" "22" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "20" "0" "0.937" "0.964" "0.930" "0.834" "0.934" "0.920" "0.944" "0.908" "0.938" "1818.3" "1704.0" "1753.2" "1691.4" "1516.1" "1698.0" "1673.1" "1715.7" "1651.1" "1705.5" "" "" "" "" "" "" "" "" "" "" "1460.4" "1229.5" "1392.6" "1133.2" "1048.6" "1274.0" "1171.4" "1253.0" "1651.1" "1387.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5340528139668487905" "False" "High" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "0.000" "False" "124.651" "28" "14" "25" "14" "613" "66.9" "8.95" "90.61" "14" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "3" "0" "0.939" "0.905" "0.927" "0.984" "1.009" "0.989" "0.958" "1.009" "0.947" "2134.1" "2004.3" "1931.4" "1977.9" "2100.3" "2152.6" "2109.6" "2044.5" "2153.6" "2021.2" "" "" "" "" "" "" "" "" "" "" "1714.0" "1446.2" "1534.2" "1325.2" "1452.6" "1615.1" "1477.0" "1493.1" "2153.6" "1643.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8220013005457955452" "False" "High" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "0.000" "False" "124.245" "23" "17" "36" "12" "915" "102.6" "5.47" "126.02" "17" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "SUMOylation of transcription cofactors" "Interleukin-1 (IL-1) structural pathway" "2" "4" "0.921" "0.952" "1.033" "0.970" "0.998" "1.139" "1.077" "1.034" "0.968" "2503.9" "2306.4" "2384.6" "2586.6" "2427.7" "2499.5" "2851.1" "2696.5" "2588.6" "2423.6" "" "" "" "" "" "" "" "" "" "" "2011.1" "1664.3" "1894.2" "1733.0" "1679.0" "1875.3" "1996.2" "1969.2" "2588.6" "1970.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390977729729594241" "False" "High" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "0.000" "False" "124.243" "25" "25" "46" "25" "1019" "117.9" "6.61" "146.00" "25" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Ub-specific processing proteases; Peroxisomal protein import; Insulin receptor recycling" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "5" "0" "0.978" "0.986" "0.976" "0.970" "0.986" "0.921" "0.942" "0.963" "0.973" "4871.6" "4766.8" "4801.3" "4753.0" "4726.3" "4803.5" "4485.1" "4588.3" "4693.3" "4741.8" "" "" "" "" "" "" "" "" "" "" "3912.8" "3439.6" "3813.8" "3184.5" "3268.8" "3604.0" "3140.2" "3350.8" "4693.3" "3856.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3241468308071992901" "False" "High" "IsMasterProtein" "Q8NI08" "Nuclear receptor coactivator 7 OS=Homo sapiens OX=9606 GN=NCOA7 PE=1 SV=2" "0.000" "False" "124.033" "23" "16" "20" "16" "942" "106.1" "5.59" "78.23" "16" "stress response;other biological processes" "nucleus" "other molecular function" "Pf01476, Pf07534" "135112" "ENSG00000111912" "NCOA7" "B2RNS2; B7Z2C4; B9EH71; G8JL91; hsa:135112; Q3LID6; Q4G0V1; Q5TF95; Q6IPQ4; Q6NE83; Q86T89; Q8N1W4; Q8NI08" "" "Aryl hydrocarbon receptor pathway" "1" "0" "0.956" "0.930" "0.949" "0.991" "0.938" "0.958" "0.982" "0.967" "0.959" "1567.9" "1498.5" "1457.8" "1487.4" "1553.8" "1470.9" "1502.8" "1539.9" "1516.5" "1503.2" "" "" "" "" "" "" "" "" "" "" "1259.3" "1081.3" "1158.0" "996.5" "1074.6" "1103.6" "1052.2" "1124.6" "1516.5" "1222.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2537127350626285919" "False" "High" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "0.000" "False" "123.836" "33" "20" "40" "20" "708" "80.5" "5.90" "121.34" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "31" "0" "1.011" "0.984" "1.038" "1.050" "1.000" "1.015" "1.003" "1.019" "1.015" "2918.4" "2949.2" "2873.0" "3030.5" "3065.5" "2919.2" "2962.1" "2927.2" "2975.2" "2961.9" "" "" "" "" "" "" "" "" "" "" "2344.0" "2128.1" "2282.1" "2030.4" "2120.1" "2190.2" "2073.9" "2137.7" "2975.2" "2408.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7060921209574590531" "False" "High" "IsMasterProtein" "Q01780" "Exosome complex component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2" "0.000" "False" "123.763" "25" "18" "26" "18" "885" "100.8" "8.46" "97.97" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00570, Pf01612, Pf08066" "5394" "ENSG00000171824" "EXOSC10" "B1AKQ0; B1AKQ1; hsa:5394; Q01780; Q15158" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.043" "1.026" "1.058" "1.045" "1.050" "1.059" "1.137" "1.096" "1.065" "3003.7" "3131.8" "3080.7" "3178.3" "3140.0" "3153.6" "3181.8" "3415.7" "3291.8" "3198.3" "" "" "" "" "" "" "" "" "" "" "2412.6" "2259.9" "2447.1" "2129.5" "2171.7" "2366.1" "2227.7" "2494.5" "3291.8" "2601.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771737938610614120" "False" "High" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "0.000" "False" "123.761" "28" "18" "25" "18" "881" "96.7" "4.55" "90.51" "18" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "COPII-mediated vesicle transport" "" "1" "0" "1.009" "1.036" "1.023" "0.977" "0.966" "0.908" "0.999" "0.993" "1.005" "1812.9" "1829.2" "1877.4" "1855.2" "1770.6" "1751.7" "1645.4" "1811.8" "1800.9" "1822.7" "" "" "" "" "" "" "" "" "" "" "1456.1" "1319.9" "1491.3" "1243.0" "1224.6" "1314.3" "1152.0" "1323.2" "1800.9" "1482.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752239950939414056" "False" "High" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "0.000" "False" "123.592" "43" "12" "33" "12" "421" "44.9" "7.52" "118.24" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "22q11.2 copy number variation syndrome" "4" "0" "1.047" "1.069" "1.035" "1.014" "1.023" "0.953" "0.970" "1.033" "1.023" "2213.7" "2316.9" "2365.7" "2290.3" "2243.7" "2264.8" "2109.5" "2146.4" "2287.6" "2264.8" "" "" "" "" "" "" "" "" "" "" "1778.0" "1671.8" "1879.1" "1534.5" "1551.7" "1699.2" "1477.0" "1567.5" "2287.6" "1841.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-987846664266598251" "False" "High" "IsMasterProtein" "Q9NS87" "Kinesin-like protein KIF15 OS=Homo sapiens OX=9606 GN=KIF15 PE=1 SV=1" "0.000" "False" "123.451" "19" "27" "34" "27" "1388" "160.1" "6.00" "114.92" "27" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00225, Pf15908" "56992" "ENSG00000163808; ENSG00000280610" "KIF15" "hsa:56992; Q17RV9; Q69YL6; Q96JX7; Q9H280; Q9NS87" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "Gastric cancer network 1" "4" "0" "1.024" "1.013" "1.022" "0.976" "1.022" "0.994" "0.964" "1.006" "0.990" "3457.8" "3541.0" "3504.1" "3535.1" "3373.9" "3533.0" "3437.7" "3332.5" "3478.4" "3421.8" "" "" "" "" "" "" "" "" "" "" "2777.3" "2555.1" "2783.4" "2368.5" "2333.4" "2650.7" "2406.9" "2433.7" "3478.4" "2782.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3787459776374465912" "False" "High" "IsMasterProtein" "Q9Y5L0" "Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3" "0.000" "False" "123.277" "26" "20" "31" "20" "923" "104.1" "5.57" "109.87" "20" "transport" "other membranes;nucleus;other cell component" "other molecular function" "Pf08389" "23534" "ENSG00000064419" "TNPO3" "A4D1K9; C9IZM0; hsa:23534; Q6NUM1; Q96G71; Q96GU9; Q9Y3R2; Q9Y5L0" "" "" "0" "0" "0.989" "0.999" "0.996" "0.997" "0.988" "1.000" "0.985" "0.966" "1.008" "2806.0" "2774.6" "2803.0" "2794.4" "2797.0" "2772.3" "2807.2" "2764.2" "2710.4" "2827.2" "" "" "" "" "" "" "" "" "" "" "2253.8" "2002.1" "2226.5" "1872.2" "1934.4" "2080.0" "1965.5" "2018.7" "2710.4" "2299.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1079834079423301401" "False" "High" "IsMasterProtein" "Q8TD19" "Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2" "0.000" "False" "123.156" "21" "16" "26" "16" "979" "107.1" "5.74" "101.68" "16" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00415, Pf13540" "91754" "ENSG00000119638" "NEK9" "hsa:91754; Q52LK6; Q8NCN0; Q8TCY4; Q8TD19; Q9UPI4; Q9Y6S4; Q9Y6S5; Q9Y6S6" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "Ciliopathies" "4" "0" "1.059" "1.047" "0.989" "0.978" "0.984" "0.944" "1.033" "0.996" "1.030" "2886.9" "3058.0" "3021.5" "2855.0" "2823.2" "2841.0" "2724.0" "2981.2" "2876.6" "2972.5" "" "" "" "" "" "" "" "" "" "" "2318.7" "2206.5" "2400.1" "1912.8" "1952.6" "2131.6" "1907.2" "2177.2" "2876.6" "2417.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1710957495581241362" "False" "High" "IsMasterProtein" "Q15276" "Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2" "0.000" "False" "123.080" "33" "30" "36" "30" "862" "99.2" "5.01" "123.22" "30" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03528, Pf09311" "9135" "ENSG00000029725" "RABEP1" "B2RAG7; hsa:9135; O95369; Q15276; Q8IVX3" "TBC/RABGAPs" "GDNF signaling" "2" "0" "0.959" "0.931" "0.932" "0.958" "0.948" "0.925" "0.892" "0.955" "0.969" "3330.6" "3194.5" "3099.5" "3103.5" "3189.9" "3156.1" "3079.7" "2970.3" "3179.2" "3226.4" "" "" "" "" "" "" "" "" "" "" "2675.1" "2305.1" "2462.1" "2079.3" "2206.1" "2368.0" "2156.2" "2169.2" "3179.2" "2623.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2805084755290845876" "False" "High" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "0.000" "False" "123.009" "24" "15" "31" "15" "790" "91.8" "6.43" "107.37" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Regulation of expression of SLITs and ROBOs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Processing of Intronless Pre-mRNAs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing; 3q29 copy number variation syndrome" "29" "0" "0.985" "1.007" "0.972" "0.966" "1.003" "0.944" "0.990" "0.960" "0.982" "2725.6" "2685.4" "2745.2" "2648.7" "2632.6" "2734.5" "2573.7" "2697.6" "2617.8" "2675.6" "" "" "" "" "" "" "" "" "" "" "2189.2" "1937.7" "2180.6" "1774.6" "1820.7" "2051.6" "1802.0" "1970.0" "2617.8" "2175.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5974744531153524067" "False" "High" "IsMasterProtein" "Q01581" "Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCS1 PE=1 SV=2" "0.000" "False" "122.703" "29" "15" "50" "15" "520" "57.3" "5.41" "170.06" "15" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01154, Pf08540" "3157" "ENSG00000112972" "HMGCS1" "B2RDL8; hsa:3157; Q01581" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "13" "0" "0.937" "0.984" "0.920" "0.919" "0.934" "0.944" "0.946" "0.990" "0.973" "4820.0" "4516.5" "4741.0" "4432.2" "4427.4" "4500.2" "4549.0" "4560.0" "4769.5" "4690.7" "" "" "" "" "" "" "" "" "" "" "3871.4" "3259.0" "3765.9" "2969.6" "3062.0" "3376.4" "3185.0" "3330.2" "4769.5" "3814.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1108045160068185156" "False" "High" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "0.000" "False" "122.545" "35" "16" "42" "16" "488" "52.7" "5.68" "129.40" "16" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "" "0" "0" "1.027" "1.023" "1.030" "0.960" "0.985" "0.907" "0.910" "0.964" "0.974" "4055.7" "4165.0" "4147.7" "4175.7" "3894.2" "3993.9" "3679.7" "3689.2" "3911.3" "3949.3" "" "" "" "" "" "" "" "" "" "" "3257.5" "3005.3" "3294.7" "2797.7" "2693.2" "2996.6" "2576.3" "2694.2" "3911.3" "3211.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6518875519697934580" "False" "High" "IsMasterProtein" "Q92576" "PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3" "0.000" "False" "122.545" "13" "22" "27" "22" "2039" "229.3" "6.96" "104.92" "22" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00628, Pf07500, Pf07744" "23469" "ENSG00000118482" "PHF3" "A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45" "" "" "0" "0" "1.038" "1.067" "1.061" "1.079" "1.052" "1.068" "1.107" "1.108" "1.101" "1986.2" "2061.5" "2118.6" "2108.2" "2143.9" "2089.9" "2121.1" "2198.6" "2200.9" "2187.7" "" "" "" "" "" "" "" "" "" "" "1595.3" "1487.5" "1682.9" "1412.5" "1482.8" "1568.0" "1485.1" "1605.6" "2200.9" "1779.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428916693947129614" "False" "High" "IsMasterProtein" "Q92556" "Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2" "0.000" "False" "122.452" "34" "24" "48" "18" "727" "83.8" "6.28" "146.64" "24" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf04727, Pf11841, Pf16457" "9844" "ENSG00000155849" "ELMO1" "A4D1X6; hsa:9844; Q29R79; Q6ZTJ0; Q92556; Q96PB0; Q9H0I1" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction" "Chemokine signaling pathway; CCL18 signaling pathway" "7" "3" "1.010" "1.002" "0.983" "0.986" "0.982" "0.951" "0.933" "0.959" "0.979" "4601.3" "4646.2" "4611.8" "4523.2" "4536.7" "4518.0" "4374.3" "4291.3" "4414.1" "4503.2" "" "" "" "" "" "" "" "" "" "" "3695.7" "3352.5" "3663.3" "3030.6" "3137.6" "3389.8" "3062.7" "3134.0" "4414.1" "3662.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786951349264090061" "False" "High" "IsMasterProtein" "Q9P2I0" "Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2" "0.000" "False" "122.448" "28" "16" "25" "16" "782" "88.4" "5.11" "90.33" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07521, Pf10996, Pf13299, Pf16661" "53981" "ENSG00000165934" "CPSF2" "B3KME1; hsa:53981; Q6NSJ1; Q9H3W7; Q9P2I0" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "1.046" "1.040" "0.994" "1.065" "1.023" "1.031" "1.025" "1.015" "1.024" "1895.5" "1983.4" "1971.1" "1884.0" "2018.1" "1938.8" "1954.4" "1942.4" "1923.8" "1940.2" "" "" "" "" "" "" "" "" "" "" "1522.4" "1431.1" "1565.7" "1262.2" "1395.8" "1454.6" "1368.4" "1418.5" "1923.8" "1577.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-996241339141020167" "False" "High" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "0.000" "False" "122.154" "24" "23" "31" "23" "1091" "126.2" "6.99" "96.20" "23" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13476" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "0.997" "0.937" "1.020" "1.038" "1.013" "0.966" "0.949" "0.953" "0.979" "2055.9" "2049.6" "1926.7" "2097.5" "2134.4" "2083.5" "1986.0" "1951.7" "1959.8" "2011.9" "" "" "" "" "" "" "" "" "" "" "1651.3" "1478.9" "1530.5" "1405.3" "1476.2" "1563.2" "1390.5" "1425.3" "1959.8" "1636.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2641060010654775307" "False" "High" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "0.000" "False" "122.135" "40" "17" "46" "17" "456" "52.9" "7.65" "139.24" "17" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "0.966" "0.955" "0.961" "0.974" "0.948" "0.929" "0.924" "0.927" "0.952" "4345.1" "4197.3" "4151.2" "4176.8" "4230.1" "4118.4" "4034.9" "4012.9" "4027.5" "4135.3" "" "" "" "" "" "" "" "" "" "" "3490.0" "3028.7" "3297.4" "2798.5" "2925.6" "3090.0" "2825.0" "2930.6" "4027.5" "3363.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3191297454369684242" "False" "High" "IsMasterProtein" "Q8WZ42" "Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4" "0.000" "False" "121.927" "1" "35" "35" "35" "34350" "3813.7" "6.35" "101.48" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;kinase activity;other molecular function" "Pf00041, Pf00069, Pf02818, Pf07679, Pf09042, Pf18362" "7273" "ENSG00000155657" "TTN" "A6NKB1; E7EQE6; E7ET18; hsa:7273; K7ENY1; Q10465; Q10466; Q15598; Q2XUS3; Q32Q60; Q4U1Z6; Q4ZG20; Q6NSG0; Q6PDB1; Q6PJP0; Q7KYM2; Q7KYN4; Q7KYN5; Q7LDM3; Q7Z2X3; Q8TCG8; Q8WZ42; Q8WZ51; Q8WZ52; Q8WZ53; Q8WZB3; Q92761; Q92762; Q9UD97; Q9UP84; Q9Y6L9" "Platelet degranulation ; Striated Muscle Contraction" "Striated muscle contraction pathway; Cardiomyocyte signaling pathways converging on titin" "4" "0" "0.952" "1.026" "1.036" "1.009" "1.063" "1.086" "0.978" "1.027" "1.035" "1249.2" "1189.8" "1281.9" "1294.4" "1260.0" "1327.5" "1356.2" "1221.2" "1282.8" "1293.4" "" "" "" "" "" "" "" "" "" "" "1003.4" "858.5" "1018.2" "867.3" "871.4" "996.0" "949.6" "891.8" "1282.8" "1051.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7322766248926009386" "False" "High" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "0.000" "False" "121.753" "27" "10" "23" "10" "534" "60.2" "5.40" "94.51" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Neddylation" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "4" "0" "1.002" "0.985" "0.934" "1.007" "0.941" "0.947" "0.962" "0.979" "0.959" "1868.6" "1872.5" "1840.8" "1745.0" "1882.0" "1758.6" "1769.2" "1797.4" "1829.8" "1791.9" "" "" "" "" "" "" "" "" "" "" "1500.8" "1351.1" "1462.2" "1169.2" "1301.6" "1319.4" "1238.7" "1312.6" "1829.8" "1457.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "623640857413414358" "False" "High" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "0.000" "False" "121.722" "64" "16" "155" "10" "247" "28.3" "4.89" "400.27" "16" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "22" "2" "0.979" "1.023" "0.966" "1.011" "1.087" "1.014" "1.013" "1.101" "1.039" "6266.4" "6134.0" "6413.6" "6050.8" "6336.4" "6814.0" "6356.4" "6348.1" "6901.0" "6512.2" "" "" "" "" "" "" "" "" "" "" "5033.1" "4426.1" "5094.5" "4054.0" "4382.3" "5112.4" "4450.4" "4636.1" "6901.0" "5295.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-16918109513615625" "False" "High" "IsMasterProtein" "P51149" "Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1" "0.000" "False" "121.701" "66" "11" "32" "11" "207" "23.5" "6.70" "114.94" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "7879" "ENSG00000075785" "RAB7A" "A8K3V6; hsa:7879; P51149; Q9NWJ0; Q9UPB0" "Neutrophil degranulation; Prevention of phagosomal-lysosomal fusion; RAB geranylgeranylation; TBC/RABGAPs; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAB GEFs exchange GTP for GDP on RABs; MHC class II antigen presentation; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Suppression of autophagy; RHOH GTPase cycle" "Ebola virus infection in host; Autosomal recessive osteopetrosis pathways; Intracellular trafficking proteins involved in CMT neuropathy" "20" "0" "0.933" "1.026" "0.915" "0.935" "0.972" "0.898" "0.903" "0.944" "0.974" "3273.5" "3053.5" "3359.7" "2996.4" "3059.8" "3180.7" "2940.2" "2956.0" "3089.1" "3189.5" "" "" "" "" "" "" "" "" "" "" "2629.3" "2203.3" "2668.7" "2007.6" "2116.2" "2386.4" "2058.5" "2158.8" "3089.1" "2593.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7811403610276720073" "False" "High" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "0.000" "False" "121.619" "41" "22" "38" "22" "621" "72.0" "8.70" "125.34" "22" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.966" "1.002" "0.993" "1.005" "1.007" "0.991" "0.993" "0.995" "0.995" "3585.0" "3464.0" "3593.2" "3560.9" "3604.1" "3608.4" "3553.2" "3560.1" "3567.9" "3568.7" "" "" "" "" "" "" "" "" "" "" "2879.4" "2499.5" "2854.2" "2385.8" "2492.6" "2707.3" "2487.8" "2599.9" "3567.9" "2902.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2657182436335150623" "False" "High" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "0.000" "False" "121.258" "41" "18" "34" "18" "505" "55.2" "7.23" "114.08" "18" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "tRNA processing in the nucleus" "Unfolded protein response" "2" "0" "0.978" "1.037" "0.984" "1.060" "1.027" "1.046" "1.016" "1.019" "1.011" "2939.1" "2875.1" "3046.4" "2891.7" "3116.1" "3017.3" "3074.9" "2986.7" "2994.9" "2970.2" "" "" "" "" "" "" "" "" "" "" "2360.6" "2074.6" "2419.8" "1937.4" "2155.2" "2263.8" "2152.9" "2181.2" "2994.9" "2415.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602445909866352508" "False" "High" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "0.000" "False" "121.147" "31" "25" "47" "25" "710" "76.6" "4.70" "151.84" "25" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Major pathway of rRNA processing in the nucleolus and cytosol; Respiratory syncytial virus (RSV) attachment and entry" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "4" "0" "1.013" "1.398" "1.089" "0.931" "1.012" "1.026" "1.077" "0.965" "1.034" "6224.9" "6303.1" "8700.8" "6779.7" "5796.3" "6301.3" "6389.0" "6702.2" "6008.9" "6433.6" "" "" "" "" "" "" "" "" "" "" "4999.8" "4548.1" "6911.3" "4542.4" "4008.8" "4727.7" "4473.3" "4894.6" "6008.9" "5232.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6733467377289635687" "False" "High" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "0.000" "False" "121.144" "39" "16" "41" "7" "428" "49.0" "5.67" "144.73" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RHOBTB2 GTPase cycle" "" "5" "0" "0.967" "0.965" "1.013" "1.000" "1.031" "1.002" "1.003" "1.006" "1.058" "767.4" "741.9" "740.8" "777.2" "767.5" "791.3" "769.3" "769.3" "772.4" "811.6" "" "" "" "" "" "" "" "" "" "" "616.4" "535.4" "588.4" "520.7" "530.8" "593.7" "538.6" "561.9" "772.4" "660.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7688952667704275831" "False" "High" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "0.000" "False" "120.875" "56" "12" "46" "8" "248" "27.9" "8.46" "161.27" "12" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.993" "0.993" "0.936" "0.995" "1.012" "0.984" "0.961" "1.023" "0.975" "4103.5" "4075.7" "4076.0" "3841.8" "4084.7" "4153.7" "4036.6" "3944.6" "4197.1" "3999.2" "" "" "" "" "" "" "" "" "" "" "3295.9" "2940.9" "3237.7" "2574.0" "2825.0" "3116.4" "2826.2" "2880.8" "4197.1" "3252.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365252663665012706" "False" "High" "IsMasterProtein" "P49589" "Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS1 PE=1 SV=3" "0.000" "False" "120.811" "27" "18" "34" "18" "748" "85.4" "6.76" "119.28" "18" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01406" "833" "ENSG00000110619; ENSG00000278191" "CARS1" "hsa:833; P49589; Q53XI8; Q5HYE4; Q9HD24; Q9HD25" "Signaling by ALK fusions and activated point mutants; Cytosolic tRNA aminoacylation" "" "2" "0" "0.979" "0.960" "0.982" "0.964" "0.971" "0.938" "0.940" "0.947" "0.947" "2553.1" "2499.1" "2451.7" "2508.3" "2461.2" "2478.8" "2394.1" "2398.9" "2418.8" "2417.2" "" "" "" "" "" "" "" "" "" "" "2050.6" "1803.3" "1947.4" "1680.6" "1702.2" "1859.8" "1676.2" "1751.9" "2418.8" "1965.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6979633451004201219" "False" "High" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "0.000" "False" "120.725" "65" "15" "142" "6" "246" "28.1" "4.83" "368.92" "15" "signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "33" "0" "1.025" "1.019" "0.967" "0.952" "1.027" "1.010" "1.031" "1.052" "1.036" "1629.7" "1669.6" "1660.9" "1575.1" "1552.2" "1673.3" "1645.3" "1680.5" "1714.6" "1688.1" "" "" "" "" "" "" "" "" "" "" "1308.9" "1204.7" "1319.3" "1055.3" "1073.5" "1255.5" "1151.9" "1227.3" "1714.6" "1372.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2986049448252169894" "False" "High" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "0.000" "False" "120.481" "23" "27" "43" "22" "1231" "141.2" "5.43" "132.27" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "Estrogen-dependent gene expression; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Meiotic synapsis; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "9" "4" "1.013" "1.002" "1.001" "0.971" "0.959" "0.959" "0.976" "0.955" "0.974" "3604.4" "3652.2" "3612.2" "3609.1" "3498.4" "3456.1" "3456.9" "3519.7" "3443.9" "3510.3" "" "" "" "" "" "" "" "" "" "" "2895.0" "2635.3" "2869.3" "2418.1" "2419.5" "2593.0" "2420.3" "2570.4" "3443.9" "2854.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-877235499680530927" "False" "High" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "0.000" "False" "120.443" "44" "12" "63" "6" "365" "38.6" "6.79" "192.19" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1 activates/modulates innate immune responses" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "7" "1" "1.023" "0.979" "1.052" "1.064" "1.023" "1.055" "1.045" "0.972" "1.056" "1513.0" "1547.8" "1480.8" "1591.0" "1610.5" "1547.5" "1596.6" "1581.3" "1470.1" "1598.0" "" "" "" "" "" "" "" "" "" "" "1215.2" "1116.8" "1176.2" "1066.0" "1113.8" "1161.1" "1117.9" "1154.8" "1470.1" "1299.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3541019235990541605" "False" "High" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "0.000" "False" "120.326" "53" "20" "44" "20" "376" "42.9" "5.81" "150.25" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "ER-Phagosome pathway; Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Downstream TCR signaling; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Separation of Sister Chromatids; Neddylation; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "0.973" "0.990" "0.968" "0.940" "0.941" "0.926" "0.937" "0.904" "0.923" "4939.4" "4805.0" "4890.4" "4782.9" "4644.9" "4650.1" "4575.7" "4630.7" "4465.5" "4559.1" "" "" "" "" "" "" "" "" "" "" "3967.3" "3467.1" "3884.6" "3204.6" "3212.5" "3488.9" "3203.6" "3381.8" "4465.5" "3707.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4220399671961536759" "False" "High" "IsMasterProtein" "Q92918" "Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP4K1 PE=1 SV=1" "0.000" "False" "119.976" "24" "16" "35" "16" "833" "91.2" "8.34" "118.25" "16" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11184" "ENSG00000104814" "MAP4K1" "hsa:11184; Q92918" "" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; T-cell receptor signaling pathway" "14" "0" "1.065" "1.003" "1.021" "1.054" "1.021" "0.974" "1.028" "1.016" "1.049" "1926.4" "2052.4" "1932.4" "1967.0" "2029.7" "1967.4" "1875.8" "1979.8" "1957.0" "2019.9" "" "" "" "" "" "" "" "" "" "" "1547.3" "1480.9" "1535.0" "1317.9" "1403.8" "1476.1" "1313.4" "1445.9" "1957.0" "1642.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523949865199722082" "False" "High" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "0.000" "False" "119.937" "33" "12" "38" "12" "478" "52.9" "5.82" "118.59" "12" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "Inactivation, recovery and regulation of the phototransduction cascade" "" "1" "0" "1.000" "1.039" "1.069" "1.132" "1.069" "1.058" "1.099" "1.237" "1.052" "2070.9" "2070.5" "2151.9" "2214.0" "2344.2" "2213.8" "2190.3" "2275.8" "2560.8" "2178.5" "" "" "" "" "" "" "" "" "" "" "1663.3" "1494.0" "1709.3" "1483.3" "1621.3" "1660.9" "1533.5" "1662.0" "2560.8" "1771.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "397277040626667291" "False" "High" "IsMasterProtein" "Q9UBB4" "Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1" "0.000" "False" "119.829" "40" "17" "38" "17" "475" "53.5" "5.25" "126.87" "17" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09759" "25814" "ENSG00000130638" "ATXN10" "A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4" "" "Ciliopathies" "1" "0" "1.036" "1.041" "0.990" "1.027" "1.014" "0.995" "1.043" "1.015" "1.016" "3615.2" "3746.0" "3764.0" "3577.7" "3713.0" "3667.5" "3596.0" "3768.9" "3670.5" "3671.6" "" "" "" "" "" "" "" "" "" "" "2903.7" "2703.0" "2989.8" "2397.1" "2567.9" "2751.7" "2517.7" "2752.4" "3670.5" "2985.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833035186099414895" "False" "High" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "0.000" "False" "119.827" "21" "19" "32" "19" "1074" "116.9" "9.04" "94.50" "19" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874, Pf20965" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "" "Exercise-induced circadian regulation" "1" "0" "1.039" "1.007" "1.054" "1.111" "1.016" "1.061" "1.146" "1.056" "1.044" "2335.2" "2426.3" "2352.0" "2462.2" "2595.4" "2371.8" "2477.0" "2675.5" "2466.3" "2438.4" "" "" "" "" "" "" "" "" "" "" "1875.6" "1750.7" "1868.3" "1649.7" "1795.0" "1779.6" "1734.3" "1953.9" "2466.3" "1983.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1136415192925944721" "False" "High" "IsMasterProtein" "Q04864" "Proto-oncogene c-Rel OS=Homo sapiens OX=9606 GN=REL PE=1 SV=1" "0.000" "False" "119.827" "30" "17" "34" "17" "619" "68.5" "5.86" "125.00" "17" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5966" "ENSG00000162924" "REL" "hsa:5966; Q04864; Q17RU2; Q2PNZ7; Q6LDY0" "Activation of NF-kappaB in B cells" "IL-1 signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; miRNA role in immune response in sepsis; Canonical NF-kB pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways; T-cell receptor signaling pathway" "20" "0" "0.998" "1.012" "1.048" "1.044" "1.002" "1.042" "1.068" "1.050" "1.024" "2389.0" "2384.6" "2417.5" "2504.4" "2493.2" "2394.2" "2488.6" "2550.9" "2509.1" "2445.8" "" "" "" "" "" "" "" "" "" "" "1918.8" "1720.7" "1920.3" "1677.9" "1724.3" "1796.3" "1742.4" "1862.9" "2509.1" "1989.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-294736394566280624" "False" "High" "IsMasterProtein" "Q16204" "Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2" "0.000" "False" "119.549" "42" "19" "37" "19" "474" "53.3" "7.34" "135.05" "19" "cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf09755" "8030" "ENSG00000108091" "CCDC6" "hsa:8030; Q15250; Q16204; Q6GSG7" "" "Retinoblastoma gene in cancer; Mesodermal commitment pathway; 16p11.2 proximal deletion syndrome" "3" "0" "1.008" "0.984" "1.048" "1.044" "1.018" "1.030" "1.001" "1.027" "1.039" "3711.6" "3742.8" "3650.6" "3891.6" "3876.5" "3778.2" "3822.6" "3715.4" "3812.5" "3855.5" "" "" "" "" "" "" "" "" "" "" "2981.1" "2700.7" "2899.8" "2607.4" "2681.0" "2834.7" "2676.4" "2713.4" "3812.5" "3135.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479790111935506116" "False" "High" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "0.000" "False" "119.362" "39" "20" "35" "20" "522" "56.0" "8.78" "133.02" "20" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.031" "0.982" "1.026" "1.045" "1.005" "1.058" "1.021" "1.075" "1.055" "2520.6" "2598.3" "2474.1" "2587.2" "2634.7" "2532.9" "2667.0" "2573.4" "2710.9" "2659.2" "" "" "" "" "" "" "" "" "" "" "2024.5" "1874.8" "1965.3" "1733.4" "1822.2" "1900.4" "1867.3" "1879.3" "2710.9" "2162.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005223025872710581" "False" "High" "IsMasterProtein" "O60524" "Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "0.000" "False" "118.958" "20" "20" "33" "20" "1076" "122.9" "6.35" "106.47" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "0.986" "1.006" "0.980" "0.974" "0.971" "0.940" "0.983" "0.976" "0.975" "3868.0" "3814.9" "3891.6" "3792.2" "3768.3" "3755.3" "3637.5" "3804.1" "3773.5" "3769.5" "" "" "" "" "" "" "" "" "" "" "3106.7" "2752.7" "3091.2" "2540.8" "2606.2" "2817.5" "2546.8" "2778.1" "3773.5" "3065.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4363739394428502664" "False" "High" "IsMasterProtein" "O75330" "Hyaluronan mediated motility receptor OS=Homo sapiens OX=9606 GN=HMMR PE=1 SV=2" "0.000" "False" "118.823" "33" "25" "33" "25" "724" "84.0" "5.83" "107.80" "25" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15905, Pf15908" "3161" "ENSG00000072571" "HMMR" "A8K3G2; B4E114; D3DQK9; D3DQL0; E9PCS0; hsa:3161; O75330; Q32N02; Q92767" "AURKA Activation by TPX2; Hyaluronan uptake and degradation" "" "2" "0" "1.005" "0.952" "0.976" "0.939" "0.916" "0.881" "0.860" "0.894" "0.932" "2528.4" "2540.1" "2406.5" "2467.4" "2373.7" "2315.7" "2228.2" "2174.9" "2259.4" "2355.6" "" "" "" "" "" "" "" "" "" "" "2030.8" "1832.9" "1911.5" "1653.1" "1641.7" "1737.4" "1560.0" "1588.3" "2259.4" "1915.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2351772574129659372" "False" "High" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "0.000" "False" "118.749" "34" "13" "31" "13" "517" "58.2" "7.49" "116.65" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "" "32" "0" "0.983" "1.003" "1.017" "0.948" "0.967" "0.977" "0.992" "0.972" "0.961" "2938.6" "2888.5" "2946.2" "2988.3" "2784.7" "2843.0" "2872.3" "2915.7" "2857.4" "2824.5" "" "" "" "" "" "" "" "" "" "" "2360.2" "2084.3" "2340.3" "2002.2" "1925.9" "2133.1" "2011.1" "2129.3" "2857.4" "2297.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4706681870966743539" "False" "High" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=2" "0.000" "False" "118.397" "32" "21" "30" "21" "742" "82.8" "5.10" "116.62" "21" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00035, Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A0A087X0M4; A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "1.018" "0.979" "1.027" "1.027" "1.009" "1.022" "1.032" "1.028" "1.037" "1940.8" "1975.7" "1900.0" "1993.1" "1992.4" "1959.1" "1983.0" "2002.3" "1995.9" "2013.2" "" "" "" "" "" "" "" "" "" "" "1558.9" "1425.6" "1509.2" "1335.4" "1378.0" "1469.9" "1388.4" "1462.3" "1995.9" "1637.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386147216843783893" "False" "High" "IsMasterProtein" "Q9NUU7" "ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1" "0.000" "False" "118.392" "37" "17" "38" "17" "478" "53.9" "6.58" "128.05" "17" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55308" "ENSG00000168872" "DDX19A" "B2RPL0; B4DRZ7; hsa:55308; Q53FM0; Q9NUU7" "" "" "0" "0" "1.014" "1.052" "0.983" "0.937" "0.972" "0.926" "1.000" "1.049" "1.003" "3644.5" "3697.2" "3835.1" "3583.5" "3414.6" "3543.5" "3373.6" "3646.3" "3821.9" "3655.8" "" "" "" "" "" "" "" "" "" "" "2927.2" "2667.8" "3046.3" "2401.0" "2361.6" "2658.7" "2362.0" "2662.9" "3821.9" "2973.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6330757226080927514" "False" "High" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "0.000" "False" "118.273" "61" "13" "43" "2" "309" "35.6" "5.54" "140.72" "13" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; CTLA4 inhibitory signaling; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "53" "9" "0.971" "0.967" "0.983" "0.934" "1.014" "0.964" "0.925" "0.935" "0.959" "2805.3" "2725.1" "2711.8" "2757.0" "2621.0" "2844.2" "2703.0" "2594.2" "2623.8" "2690.4" "" "" "" "" "" "" "" "" "" "" "2253.2" "1966.3" "2154.0" "1847.2" "1812.7" "2134.0" "1892.5" "1894.5" "2623.8" "2187.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8809117759024256443" "False" "High" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "0.000" "False" "118.153" "59" "13" "38" "11" "281" "31.1" "5.01" "131.47" "13" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Eukaryotic Translation Elongation" "Translation factors" "2" "1" "0.999" "1.002" "1.001" "0.951" "0.987" "0.968" "0.968" "0.949" "0.981" "2827.4" "2824.2" "2833.3" "2830.7" "2689.9" "2790.3" "2737.3" "2736.2" "2683.0" "2774.6" "" "" "" "" "" "" "" "" "" "" "2270.9" "2037.9" "2250.5" "1896.6" "1860.4" "2093.5" "1916.5" "1998.3" "2683.0" "2256.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585678134614880292" "False" "High" "IsMasterProtein" "Q9NTK5" "Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2" "0.000" "False" "117.693" "48" "18" "41" "18" "396" "44.7" "7.81" "133.07" "18" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "translation activity;other molecular function" "Pf01926, Pf06071" "29789" "ENSG00000138430" "OLA1" "D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4" "Platelet degranulation" "" "1" "0" "0.974" "0.999" "0.969" "0.935" "0.941" "0.961" "0.961" "0.952" "0.952" "5072.0" "4938.8" "5066.4" "4913.8" "4740.4" "4772.2" "4875.4" "4872.1" "4830.2" "4827.3" "" "" "" "" "" "" "" "" "" "" "4073.8" "3563.7" "4024.4" "3292.3" "3278.5" "3580.5" "3413.5" "3558.1" "4830.2" "3925.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4797790429512717329" "False" "High" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "0.000" "False" "117.689" "43" "18" "39" "17" "414" "46.6" "7.01" "118.03" "18" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "8" "0" "0.976" "1.011" "0.947" "0.944" "1.016" "0.996" "0.979" "0.999" "0.965" "2391.2" "2334.8" "2418.1" "2265.0" "2257.3" "2429.7" "2382.0" "2341.8" "2388.0" "2307.2" "" "" "" "" "" "" "" "" "" "" "1920.6" "1684.7" "1920.8" "1517.6" "1561.2" "1823.0" "1667.7" "1710.2" "2388.0" "1876.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866908035804814240" "False" "High" "IsMasterProtein" "P22059" "Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1" "0.000" "False" "117.643" "23" "16" "23" "16" "807" "89.4" "7.30" "98.66" "16" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "5007" "ENSG00000110048" "OSBP" "hsa:5007; P22059; Q6P524" "Sphingolipid de novo biosynthesis; Synthesis of bile acids and bile salts" "" "2" "0" "0.966" "0.970" "0.910" "0.913" "0.901" "0.835" "0.915" "0.936" "0.964" "3035.0" "2931.0" "2944.3" "2763.1" "2772.2" "2733.0" "2534.2" "2776.4" "2840.2" "2926.1" "" "" "" "" "" "" "" "" "" "" "2437.7" "2114.9" "2338.7" "1851.3" "1917.3" "2050.5" "1774.3" "2027.6" "2840.2" "2379.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6077570543552496726" "False" "High" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "0.000" "False" "117.633" "30" "15" "29" "15" "583" "63.4" "8.28" "106.58" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf13855" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "1.024" "0.995" "1.065" "1.025" "1.015" "1.024" "1.009" "1.046" "1.002" "2131.5" "2182.5" "2121.7" "2270.3" "2185.6" "2164.5" "2183.4" "2150.4" "2230.1" "2135.2" "" "" "" "" "" "" "" "" "" "" "1712.0" "1574.9" "1685.4" "1521.1" "1511.6" "1624.0" "1528.7" "1570.5" "2230.1" "1736.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396121455567897427" "False" "High" "IsMasterProtein" "Q9Y4K1" "Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=4" "0.000" "False" "117.580" "12" "18" "23" "18" "2131" "231.6" "5.81" "80.21" "18" "" "" "other molecular function" "Pf00030, Pf00652" "" "ENSG00000112297" "CRYBG1" "A0A0J9YWL0" "" "" "0" "0" "0.972" "0.977" "1.000" "0.993" "1.000" "0.977" "0.993" "1.004" "1.007" "2031.2" "1975.2" "1984.8" "2031.8" "2017.5" "2031.6" "1985.3" "2017.8" "2039.0" "2044.5" "" "" "" "" "" "" "" "" "" "" "1631.4" "1425.2" "1576.6" "1361.3" "1395.3" "1524.2" "1390.0" "1473.6" "2039.0" "1662.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8736083768290238180" "False" "High" "IsMasterProtein" "Cont_P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "0.000" "True" "117.356" "34" "22" "41" "11" "590" "62.3" "7.74" "121.79" "22" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "Formation of the cornified envelope; Type I hemidesmosome assembly" "" "3" "0" "0.574" "0.178" "0.380" "0.432" "0.535" "1.059" "0.450" "0.390" "0.530" "3044.3" "1747.5" "542.7" "1158.2" "1315.0" "1629.6" "3222.4" "1369.9" "1187.0" "1613.2" "" "" "" "" "" "" "" "" "" "" "2445.1" "1261.0" "431.1" "776.0" "909.5" "1222.7" "2256.2" "1000.5" "1187.0" "1311.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190744193783032342" "False" "High" "IsMasterProtein" "Q92619" "Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2" "0.000" "False" "116.985" "23" "21" "27" "21" "1136" "124.5" "6.10" "96.93" "21" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "23526" "ENSG00000180448" "ARHGAP45" "B4DTS4; F6QP70; hsa:23526; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q92619; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24" "Neutrophil degranulation; RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "" "4" "0" "1.075" "1.014" "0.999" "1.003" "0.981" "0.981" "1.056" "1.018" "0.999" "1890.7" "2032.8" "1916.8" "1889.6" "1895.8" "1855.1" "1855.4" "1995.8" "1924.5" "1889.3" "" "" "" "" "" "" "" "" "" "" "1518.6" "1466.8" "1522.6" "1266.1" "1311.2" "1391.9" "1299.1" "1457.6" "1924.5" "1536.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705238959085991770" "False" "High" "IsMasterProtein" "P08865" "Small ribosomal subunit protein uS2 OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "0.000" "False" "116.882" "52" "11" "28" "11" "295" "32.8" "4.87" "114.86" "11" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.965" "1.100" "1.019" "1.109" "1.135" "1.159" "1.010" "1.020" "1.031" "1866.3" "1801.3" "2053.2" "1901.8" "2070.1" "2118.4" "2163.4" "1884.6" "1903.6" "1924.1" "" "" "" "" "" "" "" "" "" "" "1499.0" "1299.8" "1630.9" "1274.2" "1431.7" "1589.4" "1514.7" "1376.3" "1903.6" "1564.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6088825967158896660" "False" "High" "IsMasterProtein" "O43290" "U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1" "0.000" "False" "116.869" "29" "18" "20" "18" "800" "90.2" "6.13" "82.63" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03343, Pf19252" "9092" "ENSG00000175467" "SART1" "A6NDN1; hsa:9092; O43290; Q53GB5" "mRNA Splicing - Major Pathway" "" "1" "0" "1.137" "1.184" "1.092" "1.159" "1.140" "1.206" "1.207" "1.145" "1.109" "1599.6" "1818.9" "1894.1" "1747.4" "1854.3" "1824.2" "1928.9" "1930.2" "1832.3" "1774.0" "" "" "" "" "" "" "" "" "" "" "1284.8" "1312.5" "1504.6" "1170.8" "1282.4" "1368.7" "1350.5" "1409.6" "1832.3" "1442.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186316132273188222" "False" "High" "IsMasterProtein" "Q92538" "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=3" "0.000" "False" "116.840" "17" "25" "31" "25" "1860" "206.4" "5.73" "90.72" "25" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf12783" "8729" "ENSG00000107862" "GBF1" "A0A7P0RGV0; hsa:8729; Q149P0; Q149P1; Q5VXX3; Q92538; Q96CK6; Q96HZ3; Q9H473" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; trans-Golgi Network Vesicle Budding; VxPx cargo-targeting to cilium" "" "4" "0" "1.073" "0.995" "1.040" "1.004" "0.995" "0.909" "1.000" "1.025" "1.016" "2317.0" "2485.2" "2305.5" "2409.1" "2326.3" "2305.4" "2105.7" "2316.3" "2374.3" "2354.9" "" "" "" "" "" "" "" "" "" "" "1861.0" "1793.2" "1831.3" "1614.1" "1608.9" "1729.7" "1474.3" "1691.6" "2374.3" "1915.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8006254010702621328" "False" "High" "IsMasterProtein" "Cont_P08779" "Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4" "0.000" "True" "116.800" "44" "21" "35" "6" "473" "51.2" "5.05" "111.28" "21" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00038" "3868" "ENSG00000186832" "KRT16" "A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8" "Formation of the cornified envelope" "Vitamin D receptor pathway" "3" "2" "0.394" "0.156" "0.263" "0.233" "0.207" "0.420" "0.195" "0.304" "0.365" "3114.1" "1226.1" "484.7" "818.9" "726.6" "645.0" "1309.4" "606.8" "946.8" "1136.8" "" "" "" "" "" "" "" "" "" "" "2501.2" "884.7" "385.0" "548.7" "502.5" "483.9" "916.8" "443.1" "946.8" "924.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729262198654758902" "False" "High" "IsMasterProtein" "O43396" "Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3" "0.000" "False" "116.774" "43" "9" "28" "9" "289" "32.2" "4.96" "111.62" "9" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00085, Pf06201" "9352" "ENSG00000091164" "TXNL1" "hsa:9352; O43396" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "" "7" "0" "0.985" "0.986" "1.004" "1.038" "0.980" "1.066" "1.037" "1.055" "1.010" "2665.9" "2626.0" "2628.5" "2677.4" "2767.8" "2612.4" "2842.0" "2765.5" "2811.4" "2692.0" "" "" "" "" "" "" "" "" "" "" "2141.2" "1894.9" "2087.9" "1793.9" "1914.2" "1960.0" "1989.9" "2019.6" "2811.4" "2189.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137976061761612537" "False" "High" "IsMasterProtein" "Q16512" "Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2" "0.000" "False" "116.404" "22" "18" "27" "16" "942" "103.9" "6.37" "101.21" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5585" "ENSG00000123143" "PKN1" "A8K7W5; B2R9R4; B3KVN3; hsa:5585; Q15143; Q16512; Q504U4; Q8IUV5; Q9UD44" "RAC1 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "Apoptosis-related network due to altered Notch3 in ovarian cancer; PI3K-Akt signaling pathway; IL-18 signaling pathway; G13 signaling pathway" "10" "2" "1.044" "0.976" "0.992" "1.002" "0.973" "0.997" "1.082" "1.045" "1.027" "1943.9" "2028.9" "1898.2" "1928.1" "1948.4" "1892.3" "1938.2" "2103.2" "2031.2" "1997.1" "" "" "" "" "" "" "" "" "" "" "1561.3" "1464.0" "1507.8" "1291.9" "1347.5" "1419.8" "1357.0" "1536.0" "2031.2" "1624.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6945972540220555835" "False" "High" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "0.000" "False" "116.382" "19" "21" "29" "21" "1273" "145.1" "7.25" "102.79" "21" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; NoRC negatively regulates rRNA expression; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by PPARalpha; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway; 15q11q13 copy number variation" "19" "0" "1.128" "1.038" "1.065" "1.087" "1.090" "1.051" "1.097" "1.158" "1.077" "1334.7" "1506.0" "1385.6" "1421.2" "1451.4" "1455.2" "1403.3" "1464.0" "1544.9" "1437.4" "" "" "" "" "" "" "" "" "" "" "1072.0" "1086.7" "1100.6" "952.2" "1003.8" "1091.8" "982.5" "1069.2" "1544.9" "1168.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5870318523395655526" "False" "High" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "0.000" "False" "116.361" "40" "18" "49" "18" "514" "58.7" "6.43" "157.00" "18" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "Cytosolic tRNA aminoacylation; Selenocysteine synthesis" "VEGFA-VEGFR2 signaling" "3" "0" "0.984" "0.990" "0.951" "0.973" "0.994" "0.937" "0.937" "0.957" "0.979" "3355.1" "3302.2" "3322.7" "3191.1" "3265.9" "3334.7" "3142.5" "3142.5" "3210.1" "3285.7" "" "" "" "" "" "" "" "" "" "" "2694.7" "2382.7" "2639.3" "2138.0" "2258.7" "2501.9" "2200.2" "2295.0" "3210.1" "2672.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6201262043542307507" "False" "High" "IsMasterProtein" "P34896" "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" "0.000" "False" "116.246" "36" "14" "26" "13" "483" "53.0" "7.71" "95.10" "14" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6470" "ENSG00000176974; ENSG00000284320" "SHMT1" "B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2" "Metabolism of folate and pterines; Carnitine synthesis" "Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Spina bifida; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "13" "0" "1.026" "0.992" "0.959" "1.013" "0.993" "1.000" "0.982" "0.999" "1.012" "1273.9" "1307.5" "1264.2" "1222.1" "1291.0" "1265.3" "1273.4" "1251.6" "1273.2" "1289.5" "" "" "" "" "" "" "" "" "" "" "1023.2" "943.5" "1004.2" "818.8" "892.9" "949.3" "891.6" "914.1" "1273.2" "1048.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92619424180281671" "False" "High" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "0.000" "False" "116.157" "38" "12" "32" "7" "434" "49.7" "6.67" "115.84" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "" "2q37 copy number variation syndrome" "1" "3" "0.953" "1.019" "0.902" "0.976" "0.946" "0.924" "0.950" "0.948" "0.998" "1933.4" "1843.0" "1969.5" "1744.9" "1887.2" "1828.4" "1786.1" "1836.7" "1833.7" "1928.6" "" "" "" "" "" "" "" "" "" "" "1552.9" "1329.8" "1564.4" "1169.1" "1305.2" "1371.8" "1250.5" "1341.4" "1833.7" "1568.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868843744032576337" "False" "High" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "0.000" "False" "115.905" "39" "19" "39" "19" "511" "57.2" "6.21" "127.33" "19" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "miR-517 relationship with ARCN1 and USP1" "3" "0" "0.993" "1.046" "1.014" "0.971" "0.988" "0.955" "0.983" "1.027" "0.987" "3866.3" "3840.1" "4044.5" "3919.0" "3753.5" "3819.0" "3693.1" "3800.4" "3969.3" "3815.5" "" "" "" "" "" "" "" "" "" "" "3105.4" "2770.9" "3212.7" "2625.7" "2596.0" "2865.3" "2585.7" "2775.4" "3969.3" "3102.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273803465605434037" "False" "High" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "0.000" "False" "115.394" "42" "19" "51" "19" "408" "46.8" "7.12" "154.01" "19" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "" "2" "0" "1.000" "0.996" "0.969" "0.977" "0.937" "0.971" "0.967" "0.942" "0.948" "5275.9" "5275.3" "5255.1" "5113.5" "5156.6" "4943.2" "5121.1" "5102.4" "4971.3" "5000.7" "" "" "" "" "" "" "" "" "" "" "4237.5" "3806.5" "4174.3" "3426.0" "3566.3" "3708.8" "3585.5" "3726.3" "4971.3" "4066.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337219862284108106" "False" "High" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "0.000" "False" "115.352" "34" "17" "25" "17" "564" "66.7" "6.34" "87.81" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "" "6" "0" "0.943" "1.067" "0.990" "0.973" "1.001" "1.057" "1.014" "1.033" "1.027" "2797.1" "2636.5" "2985.2" "2768.5" "2722.9" "2801.0" "2955.9" "2836.6" "2888.4" "2872.7" "" "" "" "" "" "" "" "" "" "" "2246.6" "1902.4" "2371.2" "1854.9" "1883.2" "2101.5" "2069.5" "2071.6" "2888.4" "2336.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244898098371361519" "False" "High" "IsMasterProtein" "Q86VS8" "Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2" "0.000" "False" "115.098" "32" "22" "30" "22" "718" "83.1" "5.17" "101.61" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "84376" "ENSG00000168172" "HOOK3" "D3DSY8; hsa:84376; Q86VS8; Q8NBH0; Q9BY13" "" "" "0" "0" "0.999" "0.960" "0.993" "1.015" "0.951" "1.020" "0.977" "1.032" "0.990" "2804.9" "2802.7" "2693.0" "2786.1" "2846.4" "2668.5" "2861.2" "2739.1" "2895.5" "2776.8" "" "" "" "" "" "" "" "" "" "" "2252.9" "2022.3" "2139.1" "1866.7" "1968.6" "2002.1" "2003.3" "2000.4" "2895.5" "2258.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9099132526023132947" "False" "High" "IsMasterProtein" "Q9Y6D5" "Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3" "0.000" "False" "115.084" "15" "23" "27" "15" "1785" "201.9" "6.33" "91.31" "23" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10564" "ENSG00000124198" "ARFGEF2" "hsa:10564; Q5TFT9; Q9NTS1; Q9Y6D5" "Association of TriC/CCT with target proteins during biosynthesis" "" "1" "0" "1.068" "1.041" "1.057" "1.034" "1.012" "1.027" "1.051" "1.039" "1.044" "1182.3" "1262.1" "1231.0" "1249.7" "1221.9" "1197.0" "1214.0" "1243.1" "1228.7" "1234.1" "" "" "" "" "" "" "" "" "" "" "949.6" "910.7" "977.9" "837.3" "845.1" "898.1" "850.0" "907.8" "1228.7" "1003.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080832168399393297" "False" "High" "IsMasterProtein" "Q9Y6D6" "Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2" "0.000" "False" "114.795" "15" "25" "33" "17" "1849" "208.6" "5.85" "105.66" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10565" "ENSG00000066777" "ARFGEF1" "hsa:10565; Q9NV46; Q9UFV2; Q9UNL0; Q9Y6D6" "" "" "0" "5" "0.947" "0.957" "0.954" "0.905" "0.913" "0.879" "0.879" "0.891" "0.978" "2662.0" "2520.5" "2546.5" "2539.8" "2408.5" "2429.1" "2339.1" "2338.9" "2372.8" "2603.5" "" "" "" "" "" "" "" "" "" "" "2138.1" "1818.7" "2022.8" "1701.7" "1665.7" "1822.5" "1637.7" "1708.1" "2372.8" "2117.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6804108956499343623" "False" "High" "IsMasterProtein" "Q96G03" "Phosphopentomutase OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4" "0.000" "False" "114.672" "29" "19" "35" "19" "612" "68.2" "6.73" "125.87" "19" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "55276" "ENSG00000169299" "PGM2" "B4E0G8; hsa:55276; Q53FP5; Q5QTR0; Q96G03; Q9H0P9; Q9NV22" "Neutrophil degranulation; Pentose phosphate pathway" "Clear cell renal cell carcinoma pathways; Glucuronidation" "4" "0" "0.963" "1.023" "0.926" "0.969" "0.994" "0.947" "0.975" "1.000" "0.961" "4554.6" "4384.4" "4661.1" "4216.1" "4413.2" "4528.4" "4312.6" "4439.5" "4553.1" "4379.2" "" "" "" "" "" "" "" "" "" "" "3658.2" "3163.7" "3702.5" "2824.8" "3052.2" "3397.5" "3019.4" "3242.2" "4553.1" "3561.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "114843226561293462" "False" "High" "IsMasterProtein" "P67936" "Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3" "0.000" "False" "114.522" "60" "20" "40" "10" "248" "28.5" "4.69" "122.57" "20" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7171" "ENSG00000167460" "TPM4" "hsa:7171; P07226; P67936; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4" "RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Striated Muscle Contraction" "Striated muscle contraction pathway" "5" "6" "1.040" "1.054" "1.125" "1.069" "1.115" "1.134" "1.063" "1.071" "1.053" "2746.5" "2857.0" "2894.8" "3088.8" "2935.1" "3063.1" "3115.5" "2918.7" "2942.8" "2891.3" "" "" "" "" "" "" "" "" "" "" "2206.0" "2061.5" "2299.4" "2069.5" "2029.9" "2298.2" "2181.3" "2131.5" "2942.8" "2351.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375122853346024923" "False" "High" "IsMasterProtein" "Q9C0E2" "Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2" "0.000" "False" "114.468" "24" "24" "39" "23" "1151" "130.1" "5.05" "123.55" "24" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08767" "64328" "ENSG00000132953" "XPO4" "hsa:64328; Q5VUZ5; Q8N3V6; Q9C0E2; Q9H934" "" "eIF5A regulation in response to inhibition of the nuclear export system" "1" "1" "0.967" "0.980" "1.008" "0.982" "0.971" "0.934" "0.957" "0.953" "0.986" "2426.8" "2345.7" "2378.8" "2446.7" "2382.2" "2355.9" "2267.3" "2322.7" "2313.2" "2392.8" "" "" "" "" "" "" "" "" "" "" "1949.2" "1692.6" "1889.5" "1639.3" "1647.5" "1767.6" "1587.4" "1696.3" "2313.2" "1945.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6816817128509432528" "False" "High" "IsMasterProtein" "P10155" "RNA-binding protein RO60 OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "0.000" "False" "114.411" "43" "21" "36" "21" "538" "60.6" "8.03" "113.62" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "0.963" "0.997" "0.964" "0.964" "0.955" "0.973" "0.929" "0.971" "0.963" "3540.8" "3410.6" "3529.4" "3413.4" "3412.6" "3383.3" "3443.9" "3289.1" "3438.5" "3410.2" "" "" "" "" "" "" "" "" "" "" "2844.0" "2461.0" "2803.6" "2287.0" "2360.2" "2538.4" "2411.3" "2402.1" "3438.5" "2773.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6550652705279003104" "False" "High" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "0.000" "False" "113.990" "48" "17" "41" "17" "380" "39.8" "8.94" "128.87" "17" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "Integrin-mediated cell adhesion; Focal adhesion" "5" "0" "1.009" "1.043" "1.040" "1.034" "1.037" "1.066" "0.995" "1.051" "1.045" "2843.3" "2868.6" "2965.5" "2957.4" "2941.4" "2948.1" "3032.4" "2828.1" "2987.8" "2970.2" "" "" "" "" "" "" "" "" "" "" "2283.7" "2069.9" "2355.6" "1981.5" "2034.3" "2211.9" "2123.1" "2065.4" "2987.8" "2415.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242309002880936469" "False" "High" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "0.000" "False" "113.983" "15" "24" "31" "24" "1593" "182.7" "8.44" "103.56" "24" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.007" "0.997" "0.966" "1.001" "0.980" "0.979" "0.980" "0.965" "0.976" "2894.8" "2915.7" "2887.2" "2797.5" "2898.3" "2836.2" "2835.3" "2836.0" "2793.2" "2824.7" "" "" "" "" "" "" "" "" "" "" "2325.1" "2103.9" "2293.4" "1874.3" "2004.5" "2128.0" "1985.2" "2071.1" "2793.2" "2297.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135854214922228039" "False" "High" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "0.000" "False" "113.983" "35" "17" "33" "17" "585" "64.9" "8.87" "113.77" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "3" "0" "1.003" "0.982" "0.932" "0.986" "0.981" "0.967" "0.986" "0.965" "0.965" "2964.4" "2972.2" "2912.1" "2761.4" "2924.3" "2908.8" "2865.8" "2922.6" "2861.0" "2861.3" "" "" "" "" "" "" "" "" "" "" "2381.0" "2144.6" "2313.2" "1850.1" "2022.4" "2182.4" "2006.5" "2134.4" "2861.0" "2326.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501130865097894528" "False" "High" "IsMasterProtein" "O60763" "General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2" "0.000" "False" "113.914" "21" "17" "31" "17" "962" "107.8" "4.91" "106.14" "17" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf04869, Pf04871, Pf18770" "8615" "ENSG00000138768" "USO1" "B2RAQ0; hsa:8615; O60763; Q6PK63; Q86TB8; Q8N592" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "" "3" "0" "0.981" "0.974" "1.024" "0.975" "0.945" "0.962" "0.963" "0.971" "0.978" "2486.7" "2439.7" "2421.1" "2546.0" "2425.4" "2349.0" "2393.4" "2394.8" "2415.2" "2431.8" "" "" "" "" "" "" "" "" "" "" "1997.3" "1760.4" "1923.1" "1705.8" "1677.4" "1762.4" "1675.7" "1748.9" "2415.2" "1977.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8200753479416328933" "False" "High" "IsMasterProtein" "Q8NF50" "Dedicator of cytokinesis protein 8 OS=Homo sapiens OX=9606 GN=DOCK8 PE=1 SV=3" "0.000" "False" "113.896" "15" "27" "36" "27" "2099" "238.4" "6.87" "108.31" "27" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "81704" "ENSG00000107099" "DOCK8" "A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09; hsa:81704; Q3MV16; Q5JPJ1; Q8NF50; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; Q9H1Q3; Q9H308; Q9H7P2" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RHOJ GTPase cycle; RAC1 GTPase cycle" "" "4" "0" "1.073" "1.031" "1.086" "1.015" "1.025" "1.104" "1.055" "0.998" "1.052" "1735.7" "1862.6" "1788.9" "1885.4" "1761.2" "1779.2" "1917.1" "1831.7" "1732.7" "1826.2" "" "" "" "" "" "" "" "" "" "" "1394.1" "1344.0" "1421.0" "1263.2" "1218.0" "1334.9" "1342.2" "1337.7" "1732.7" "1485.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3579121838691215902" "False" "High" "IsMasterProtein" "Q7Z6I6" "Rho GTPase-activating protein 30 OS=Homo sapiens OX=9606 GN=ARHGAP30 PE=1 SV=3" "0.000" "False" "113.795" "21" "21" "29" "21" "1101" "118.5" "4.81" "97.08" "21" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "257106" "ENSG00000186517" "ARHGAP30" "hsa:257106; Q5SY52; Q5SY53; Q5SY54; Q6ZML6; Q7Z3J8; Q7Z6I6; Q86XI7" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle" "" "4" "0" "1.048" "0.987" "1.005" "0.967" "1.009" "0.949" "0.988" "1.019" "0.998" "1803.0" "1888.7" "1780.3" "1811.7" "1744.4" "1818.8" "1711.0" "1781.3" "1838.2" "1800.0" "" "" "" "" "" "" "" "" "" "" "1448.2" "1362.8" "1414.1" "1213.8" "1206.4" "1364.6" "1198.0" "1300.9" "1838.2" "1463.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "439747598683617185" "False" "High" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "0.000" "False" "113.723" "33" "13" "21" "13" "523" "57.5" "9.38" "89.67" "13" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Recycling of eIF2:GDP" "Translation factors; Primary ovarian insufficiency" "3" "0" "1.012" "0.974" "1.003" "0.973" "0.972" "0.914" "0.979" "0.946" "0.979" "1972.9" "1995.9" "1921.8" "1978.6" "1919.9" "1917.6" "1802.5" "1931.9" "1866.8" "1931.6" "" "" "" "" "" "" "" "" "" "" "1584.6" "1440.2" "1526.5" "1325.7" "1327.8" "1438.7" "1262.0" "1410.9" "1866.8" "1570.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-504997331308259812" "False" "High" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "0.000" "False" "113.697" "42" "17" "42" "17" "413" "46.2" "7.01" "139.60" "17" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "11" "0" "0.959" "0.975" "0.913" "0.994" "0.963" "0.946" "0.932" "0.935" "0.939" "3460.1" "3317.4" "3373.0" "3157.7" "3438.9" "3331.1" "3272.8" "3224.1" "3234.4" "3249.6" "" "" "" "" "" "" "" "" "" "" "2779.1" "2393.8" "2679.2" "2115.7" "2378.3" "2499.3" "2291.4" "2354.6" "3234.4" "2642.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8415712224574136193" "False" "High" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "0.000" "False" "113.436" "33" "14" "31" "14" "483" "54.4" "8.66" "112.51" "14" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.004" "1.013" "0.995" "0.954" "1.012" "0.956" "0.957" "0.983" "0.975" "2567.4" "2577.2" "2601.8" "2553.5" "2450.3" "2599.0" "2453.3" "2456.2" "2522.6" "2502.5" "" "" "" "" "" "" "" "" "" "" "2062.1" "1859.6" "2066.7" "1710.9" "1694.7" "1950.0" "1717.7" "1793.7" "2522.6" "2035.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8640947955125983665" "False" "High" "IsMasterProtein" "Q9Y5A7" "NEDD8 ultimate buster 1 OS=Homo sapiens OX=9606 GN=NUB1 PE=1 SV=2" "0.000" "False" "113.325" "28" "15" "22" "15" "615" "70.5" "5.96" "87.66" "15" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "" "Pf00627, Pf18037" "51667" "ENSG00000013374" "NUB1" "hsa:51667; O95422; Q75MR9; Q8IX22; Q9BXR2; Q9Y5A7" "" "" "0" "0" "0.981" "1.009" "1.035" "0.991" "0.954" "0.925" "0.936" "0.963" "0.981" "1759.7" "1726.9" "1775.6" "1821.2" "1744.4" "1678.9" "1628.4" "1646.5" "1694.8" "1726.6" "" "" "" "" "" "" "" "" "" "" "1413.3" "1246.1" "1410.4" "1220.2" "1206.4" "1259.6" "1140.1" "1202.4" "1694.8" "1404.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850236467978773586" "False" "High" "IsMasterProtein" "P40692" "DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1" "0.000" "False" "113.098" "29" "21" "27" "21" "756" "84.5" "5.72" "95.17" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf13589, Pf16413" "4292" "ENSG00000076242" "MLH1" "B4DI13; B4DQ11; E9PCU2; hsa:4292; P40692" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "Ovarian infertility; Chromosomal and microsatellite instability in colorectal cancer ; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "12" "0" "1.031" "0.995" "1.060" "0.970" "1.011" "0.950" "0.991" "1.005" "0.999" "1959.3" "2019.1" "1949.9" "2076.7" "1900.7" "1981.0" "1860.8" "1942.0" "1968.9" "1956.8" "" "" "" "" "" "" "" "" "" "" "1573.7" "1457.0" "1548.8" "1391.4" "1314.5" "1486.3" "1302.8" "1418.3" "1968.9" "1591.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792882720935006206" "False" "High" "IsMasterProtein" "Q9HAV4" "Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1" "0.000" "False" "113.007" "20" "21" "33" "21" "1204" "136.2" "5.80" "103.20" "21" "RNA metabolism OR transcription;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19273" "57510" "ENSG00000124571" "XPO5" "hsa:57510; Q5JTE6; Q96G48; Q96HN3; Q9BWM6; Q9BZV5; Q9H9M4; Q9HAV4; Q9NT89; Q9NW39; Q9ULC9" "MicroRNA (miRNA) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Primary ovarian insufficiency" "4" "0" "1.017" "1.020" "1.041" "1.030" "1.018" "0.978" "1.027" "0.994" "1.056" "2751.6" "2797.3" "2806.1" "2864.3" "2834.2" "2800.2" "2689.7" "2825.3" "2735.0" "2904.5" "" "" "" "" "" "" "" "" "" "" "2210.0" "2018.4" "2229.0" "1919.1" "1960.2" "2100.9" "1883.2" "2063.3" "2735.0" "2362.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011976368699827672" "False" "High" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "0.000" "False" "112.974" "36" "15" "34" "15" "472" "51.1" "8.40" "120.43" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "14" "0" "0.987" "1.012" "0.992" "0.966" "0.969" "0.977" "0.960" "0.955" "0.954" "4429.7" "4373.2" "4482.0" "4395.5" "4280.0" "4291.4" "4325.9" "4254.2" "4230.8" "4226.2" "" "" "" "" "" "" "" "" "" "" "3557.9" "3155.6" "3560.2" "2945.0" "2960.1" "3219.7" "3028.8" "3106.8" "4230.8" "3436.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7059158695698353069" "False" "High" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "0.000" "False" "112.929" "74" "12" "29" "4" "201" "22.2" "5.73" "112.82" "12" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "" "6" "6" "1.004" "1.024" "0.990" "1.051" "1.047" "1.024" "1.021" "0.999" "1.025" "3055.6" "3067.6" "3128.5" "3025.3" "3210.6" "3199.2" "3129.9" "3121.1" "3053.4" "3131.6" "" "" "" "" "" "" "" "" "" "" "2454.2" "2213.5" "2485.0" "2027.0" "2220.5" "2400.3" "2191.4" "2279.4" "3053.4" "2546.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720248987179001386" "False" "High" "IsMasterProtein" "O60313" "Dynamin-like GTPase OPA1, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "0.000" "False" "112.850" "22" "20" "29" "20" "960" "111.6" "7.87" "103.97" "20" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Mitochondrial protein degradation; Regulation of Apoptosis" "Orexin receptor pathway" "3" "0" "0.950" "0.920" "1.003" "1.043" "1.069" "1.069" "0.942" "1.026" "0.993" "3466.1" "3293.1" "3188.4" "3477.1" "3616.8" "3706.7" "3705.4" "3265.1" "3555.0" "3441.8" "" "" "" "" "" "" "" "" "" "" "2783.9" "2376.2" "2532.6" "2329.6" "2501.4" "2781.1" "2594.3" "2384.5" "3555.0" "2799.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4323933511445947970" "False" "High" "IsMasterProtein" "P43405" "Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1" "0.000" "False" "112.841" "31" "16" "35" "16" "635" "72.0" "8.25" "115.49" "16" "cell adhesion;cell-cell signaling;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "6850" "ENSG00000165025" "SYK" "hsa:6850; P43405" "Integrin signaling; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; DAP12 signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Interleukin-2 signaling; Dectin-2 family; FLT3 signaling through SRC family kinases" "IL-5 signaling pathway; RANKL/RANK signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Microglia pathogen phagocytosis pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; IL-2 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "30" "0" "1.013" "1.055" "1.002" "0.968" "1.024" "0.900" "0.956" "0.989" "1.010" "2425.2" "2457.0" "2557.8" "2430.1" "2346.7" "2484.5" "2182.7" "2319.4" "2399.2" "2449.3" "" "" "" "" "" "" "" "" "" "" "1947.9" "1772.9" "2031.8" "1628.2" "1623.0" "1864.1" "1528.2" "1693.8" "2399.2" "1991.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900163226744829744" "False" "High" "IsMasterProtein" "Q99590" "Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2" "0.000" "False" "112.566" "16" "20" "26" "20" "1463" "164.6" "8.41" "89.31" "20" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf13639" "9169" "ENSG00000139218" "SCAF11" "A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590" "" "Apoptosis" "1" "0" "1.046" "1.097" "1.082" "1.165" "1.094" "1.205" "1.264" "1.186" "1.109" "2013.0" "2106.4" "2207.8" "2178.5" "2345.9" "2202.0" "2424.8" "2544.6" "2386.7" "2232.7" "" "" "" "" "" "" "" "" "" "" "1616.8" "1519.9" "1753.8" "1459.6" "1622.4" "1652.1" "1697.7" "1858.3" "2386.7" "1815.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5339836283997496681" "False" "High" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "0.000" "False" "112.331" "14" "15" "22" "15" "1332" "150.2" "5.94" "90.42" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HATs acetylate histones" "HDAC6 interactions in the central nervous system" "2" "0" "1.019" "0.985" "0.994" "1.013" "0.973" "0.959" "1.003" "0.970" "1.012" "1713.1" "1745.0" "1687.5" "1703.2" "1736.0" "1666.6" "1642.9" "1718.5" "1661.0" "1733.5" "" "" "" "" "" "" "" "" "" "" "1376.0" "1259.1" "1340.4" "1141.1" "1200.6" "1250.4" "1150.3" "1255.0" "1661.0" "1409.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2527179580342077355" "False" "High" "IsMasterProtein" "Q9NUQ9" "CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1" "0.000" "False" "112.263" "52" "13" "37" "11" "324" "36.7" "6.06" "130.18" "13" "cell organization and biogenesis;other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07159" "51571" "ENSG00000153310" "CYRIB" "hsa:51571; Q96AZ5; Q9NUQ9; Q9NW21; Q9NZE7" "Platelet degranulation" "" "1" "1" "0.984" "1.015" "0.937" "0.988" "1.054" "0.964" "1.019" "1.000" "0.986" "2135.0" "2100.3" "2167.1" "2001.4" "2109.5" "2250.8" "2058.4" "2176.4" "2135.6" "2105.9" "" "" "" "" "" "" "" "" "" "" "1714.8" "1515.5" "1721.4" "1341.0" "1458.9" "1688.8" "1441.2" "1589.4" "2135.6" "1712.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7622231560690593168" "False" "High" "IsMasterProtein" "Q13043" "Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2" "0.000" "False" "112.196" "50" "20" "36" "20" "487" "55.6" "5.07" "123.85" "20" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6789" "ENSG00000101109" "STK4" "B2RCR8; hsa:6789; Q13043; Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4" "Signaling by Hippo" "MAPK signaling pathway; Ras signaling; Non-small cell lung cancer" "4" "0" "1.058" "1.063" "1.070" "1.029" "1.037" "1.020" "1.066" "1.024" "1.026" "3022.9" "3199.0" "3213.2" "3233.2" "3110.3" "3134.7" "3084.0" "3223.8" "3095.8" "3102.2" "" "" "" "" "" "" "" "" "" "" "2428.0" "2308.3" "2552.4" "2166.3" "2151.1" "2351.9" "2159.2" "2354.4" "3095.8" "2522.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599424746602695209" "False" "High" "IsMasterProtein" "Q9ULE6" "Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3" "0.000" "False" "111.849" "26" "19" "25" "19" "856" "96.7" "6.54" "91.80" "19" "" "cytosol;other cell component" "other molecular function" "Pf14566" "27143" "ENSG00000107719" "PALD1" "B2RMS1; B9EGC6; hsa:27143; Q5JTK7; Q5JTK8; Q9ULE6" "" "" "0" "0" "1.142" "0.996" "1.082" "1.072" "1.032" "1.043" "1.031" "1.024" "1.055" "1816.8" "2074.4" "1810.1" "1966.0" "1947.5" "1874.8" "1894.0" "1873.5" "1859.7" "1916.1" "" "" "" "" "" "" "" "" "" "" "1459.2" "1496.9" "1437.8" "1317.2" "1346.9" "1406.6" "1326.1" "1368.2" "1859.7" "1558.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6669951735420197648" "False" "High" "IsMasterProtein" "O00154" "Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3" "0.000" "False" "111.814" "38" "11" "30" "11" "380" "41.8" "8.54" "119.77" "11" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03061" "11332" "ENSG00000097021" "ACOT7" "A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; hsa:11332; O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "0.993" "1.017" "1.041" "1.020" "1.015" "1.034" "0.985" "0.980" "1.028" "1970.4" "1956.8" "2004.4" "2050.4" "2010.7" "2000.6" "2037.4" "1941.6" "1930.8" "2026.4" "" "" "" "" "" "" "" "" "" "" "1582.6" "1412.0" "1592.1" "1373.8" "1390.6" "1501.1" "1426.5" "1417.9" "1930.8" "1647.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124389197736880790" "False" "High" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "0.000" "False" "111.604" "50" "18" "73" "18" "334" "36.4" "7.36" "195.11" "18" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Gluconeogenesis" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; HDAC6 interactions in the central nervous system" "10" "0" "0.997" "1.029" "1.002" "1.007" "1.027" "0.987" "0.968" "0.976" "0.980" "4825.9" "4809.8" "4967.3" "4834.2" "4859.8" "4958.0" "4761.8" "4669.9" "4711.2" "4727.2" "" "" "" "" "" "" "" "" "" "" "3876.1" "3470.6" "3945.7" "3238.9" "3361.0" "3719.9" "3334.0" "3410.4" "4711.2" "3844.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4258123771778816743" "False" "High" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "0.000" "False" "111.578" "22" "23" "36" "23" "1226" "136.0" "8.65" "116.50" "23" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "PKR-mediated signaling; Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "Measles virus infection; Cytosolic DNA-sensing pathway" "6" "0" "1.055" "1.100" "1.087" "1.122" "1.086" "1.085" "1.109" "1.112" "1.096" "2579.4" "2721.9" "2837.0" "2804.9" "2894.7" "2800.0" "2798.8" "2859.3" "2867.4" "2826.0" "" "" "" "" "" "" "" "" "" "" "2071.7" "1964.1" "2253.5" "1879.3" "2002.0" "2100.8" "1959.6" "2088.1" "2867.4" "2298.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563058972091496350" "False" "High" "IsMasterProtein" "P80723" "Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2" "0.000" "False" "111.292" "41" "8" "22" "8" "227" "22.7" "4.63" "93.00" "8" "developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05466" "10409" "ENSG00000176788" "BASP1" "B4DJA8; D3DTD5; hsa:10409; O43596; P80723; Q5U0S0; Q9BWA5" "RHOF GTPase cycle" "" "1" "0" "0.863" "0.841" "0.912" "0.928" "0.961" "1.038" "0.875" "0.980" "0.907" "2010.5" "1734.5" "1690.8" "1832.8" "1865.2" "1931.8" "2086.5" "1758.2" "1969.9" "1824.3" "" "" "" "" "" "" "" "" "" "" "1614.8" "1251.6" "1343.0" "1228.0" "1290.0" "1449.4" "1460.8" "1284.0" "1969.9" "1483.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058456233631452436" "False" "High" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "0.000" "False" "111.287" "55" "13" "109" "9" "199" "22.1" "8.13" "325.69" "13" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; HDAC6 interactions in the central nervous system" "9" "4" "1.005" "1.039" "1.007" "1.057" "1.003" "0.979" "0.991" "1.023" "0.980" "10342.5" "10392.6" "10744.2" "10414.7" "10928.6" "10377.8" "10128.3" "10246.3" "10585.5" "10132.8" "" "" "" "" "" "" "" "" "" "" "8307.0" "7499.0" "8534.5" "6977.9" "7558.3" "7786.2" "7091.3" "7482.9" "10585.5" "8240.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8008274239603490952" "False" "High" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "0.000" "False" "111.061" "37" "16" "57" "14" "378" "39.6" "9.01" "195.40" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "" "2" "0" "1.078" "1.084" "1.104" "1.167" "1.161" "1.179" "1.143" "1.128" "1.109" "2700.9" "2912.2" "2928.8" "2981.0" "3152.7" "3135.5" "3184.4" "3085.8" "3047.1" "2994.8" "" "" "" "" "" "" "" "" "" "" "2169.3" "2101.4" "2326.5" "1997.2" "2180.5" "2352.5" "2229.5" "2253.5" "3047.1" "2435.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1707703891335855171" "False" "High" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "0.000" "False" "110.891" "18" "25" "33" "25" "1369" "155.1" "8.09" "106.30" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.954" "0.978" "0.983" "0.953" "0.989" "0.975" "1.001" "0.998" "0.977" "3457.3" "3297.6" "3379.7" "3398.3" "3294.5" "3419.5" "3371.9" "3461.3" "3450.4" "3376.9" "" "" "" "" "" "" "" "" "" "" "2776.8" "2379.5" "2684.6" "2276.8" "2278.5" "2565.6" "2360.8" "2527.8" "3450.4" "2746.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5279606303405418158" "False" "High" "IsMasterProtein" "Q9H2K8" "Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2" "0.000" "False" "110.869" "26" "22" "33" "20" "898" "105.3" "7.30" "103.81" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "51347" "ENSG00000135090" "TAOK3" "hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "MAPK signaling pathway" "4" "1" "1.040" "1.042" "1.019" "1.034" "0.986" "0.984" "1.002" "1.068" "1.044" "1953.3" "2032.3" "2035.8" "1991.3" "2019.4" "1926.4" "1921.6" "1957.5" "2085.5" "2039.7" "" "" "" "" "" "" "" "" "" "" "1568.9" "1466.5" "1617.1" "1334.1" "1396.7" "1445.3" "1345.4" "1429.6" "2085.5" "1658.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2836831182499166141" "False" "High" "IsMasterProtein" "O00148" "ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2" "0.000" "False" "110.811" "38" "16" "44" "7" "427" "49.1" "5.68" "139.73" "16" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "10212" "ENSG00000123136" "DDX39A" "B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "9" "0.992" "1.023" "0.974" "0.996" "0.950" "0.920" "0.928" "0.927" "0.976" "3754.9" "3724.8" "3842.5" "3657.5" "3741.6" "3568.0" "3454.8" "3483.6" "3481.2" "3664.8" "" "" "" "" "" "" "" "" "" "" "3015.9" "2687.7" "3052.2" "2450.5" "2587.7" "2677.0" "2418.9" "2544.1" "3481.2" "2980.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4839945324263831738" "False" "High" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "0.000" "False" "110.398" "49" "12" "24" "12" "307" "33.7" "8.21" "87.10" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "" "Fatty acid biosynthesis" "1" "0" "1.054" "0.982" "1.054" "0.992" "0.948" "0.985" "1.006" "0.972" "1.005" "2481.0" "2616.2" "2436.9" "2615.1" "2461.6" "2351.3" "2443.5" "2496.3" "2411.9" "2494.3" "" "" "" "" "" "" "" "" "" "" "1992.7" "1887.8" "1935.7" "1752.1" "1702.5" "1764.1" "1710.8" "1823.1" "2411.9" "2028.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5795774045568999421" "False" "High" "IsMasterProtein" "Q9GZR7" "ATP-dependent RNA helicase DDX24 OS=Homo sapiens OX=9606 GN=DDX24 PE=1 SV=1" "0.000" "False" "110.396" "22" "14" "19" "14" "859" "96.3" "9.06" "82.35" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "57062" "ENSG00000089737; ENSG00000273761" "DDX24" "E7EMJ4; hsa:57062; Q4V9L5; Q9GZR7" "" "" "0" "0" "1.121" "1.021" "1.171" "1.039" "0.976" "1.082" "1.129" "1.083" "1.110" "1310.1" "1469.3" "1337.6" "1533.7" "1361.0" "1278.7" "1417.6" "1479.4" "1419.2" "1454.1" "" "" "" "" "" "" "" "" "" "" "1052.3" "1060.2" "1062.5" "1027.6" "941.3" "959.4" "992.5" "1080.4" "1419.2" "1182.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7175242905837588229" "False" "High" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "0.000" "False" "110.289" "31" "14" "21" "11" "527" "58.0" "6.43" "88.83" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "3" "1.014" "0.990" "1.004" "1.004" "0.963" "0.934" "0.957" "0.980" "0.994" "2331.5" "2365.2" "2309.2" "2340.3" "2341.5" "2244.2" "2178.4" "2231.4" "2285.9" "2317.2" "" "" "" "" "" "" "" "" "" "" "1872.7" "1706.6" "1834.2" "1568.0" "1619.4" "1683.8" "1525.2" "1629.6" "2285.9" "1884.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4886602285452216196" "False" "High" "IsMasterProtein" "Q92696" "Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2" "0.000" "False" "110.257" "37" "18" "26" "18" "567" "65.0" "5.67" "96.36" "18" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00560, Pf01239, Pf07711" "5875" "ENSG00000100949; ENSG00000285193" "RABGGTA" "A8K5N2; D3DS69; hsa:5875; Q92696" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "" "2" "0" "0.997" "0.991" "1.028" "0.985" "1.041" "0.960" "0.970" "1.021" "1.008" "2005.8" "2000.3" "1988.4" "2062.4" "1976.7" "2087.3" "1924.7" "1946.6" "2047.1" "2021.5" "" "" "" "" "" "" "" "" "" "" "1611.1" "1443.4" "1579.5" "1381.8" "1367.1" "1566.1" "1347.6" "1421.6" "2047.1" "1644.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934522081491213014" "False" "High" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "0.000" "False" "109.966" "33" "9" "23" "4" "318" "34.7" "6.61" "100.01" "9" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "0" "0.963" "0.975" "0.983" "0.970" "0.981" "1.030" "0.982" "0.943" "0.942" "1482.2" "1427.9" "1444.5" "1457.4" "1437.2" "1454.5" "1526.1" "1455.2" "1397.9" "1395.8" "" "" "" "" "" "" "" "" "" "" "1190.5" "1030.3" "1147.4" "976.5" "993.9" "1091.3" "1068.5" "1062.7" "1397.9" "1135.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3464884523288308990" "False" "High" "IsMasterProtein" "Q12972" "Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2" "0.000" "False" "109.963" "32" "8" "19" "8" "351" "38.5" "7.37" "86.72" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00498" "5511" "ENSG00000117751" "PPP1R8" "hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0" "mRNA Splicing - Major Pathway" "" "1" "0" "0.977" "1.002" "1.051" "1.097" "1.001" "1.082" "1.078" "1.036" "1.025" "1484.4" "1451.0" "1487.0" "1559.6" "1628.5" "1485.4" "1605.6" "1600.7" "1537.7" "1521.3" "" "" "" "" "" "" "" "" "" "" "1192.3" "1047.0" "1181.2" "1045.0" "1126.3" "1114.4" "1124.1" "1169.0" "1537.7" "1237.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472410284542291541" "False" "High" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "0.000" "False" "109.704" "56" "14" "39" "14" "254" "29.5" "5.95" "144.22" "14" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling" "Proteasome degradation" "60" "0" "0.960" "0.953" "0.939" "0.919" "0.872" "0.866" "0.926" "0.897" "0.916" "5045.4" "4841.7" "4806.9" "4737.3" "4635.0" "4399.2" "4368.6" "4670.7" "4527.8" "4620.2" "" "" "" "" "" "" "" "" "" "" "4052.4" "3493.6" "3818.2" "3174.0" "3205.6" "3300.7" "3058.6" "3411.0" "4527.8" "3757.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1351774447437735542" "False" "High" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "0.000" "False" "109.614" "30" "17" "28" "17" "623" "69.9" "5.67" "99.92" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "0" "0.959" "0.988" "0.906" "0.974" "0.988" "0.907" "0.910" "0.959" "0.952" "2503.0" "2401.1" "2473.0" "2267.7" "2437.8" "2473.5" "2270.6" "2278.9" "2400.3" "2382.3" "" "" "" "" "" "" "" "" "" "" "2010.4" "1732.6" "1964.4" "1519.4" "1686.0" "1855.8" "1589.7" "1664.3" "2400.3" "1937.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1520164082407222722" "False" "High" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "0.000" "False" "109.495" "75" "12" "120" "12" "140" "15.0" "8.27" "340.71" "12" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "9" "0" "0.959" "0.990" "0.941" "1.065" "1.009" "1.022" "1.008" "0.966" "1.004" "6759.6" "6481.5" "6691.6" "6358.3" "7200.1" "6819.8" "6910.6" "6816.5" "6531.3" "6787.4" "" "" "" "" "" "" "" "" "" "" "5429.3" "4676.9" "5315.3" "4260.1" "4979.7" "5116.8" "4838.4" "4978.1" "6531.3" "5519.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6898362588139573585" "False" "High" "IsMasterProtein" "Q01105" "Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3" "0.000" "False" "109.492" "30" "9" "51" "9" "290" "33.5" "4.32" "187.57" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00956" "6418" "ENSG00000119335" "SET" "A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5" "HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes" "Histone modifications; VEGFA-VEGFR2 signaling" "4" "0" "0.987" "1.035" "1.043" "1.052" "1.021" "1.107" "1.185" "1.110" "1.069" "3040.9" "3002.6" "3147.2" "3172.7" "3198.2" "3104.4" "3364.9" "3602.4" "3374.0" "3251.5" "" "" "" "" "" "" "" "" "" "" "2442.4" "2166.6" "2499.9" "2125.7" "2211.9" "2329.2" "2355.9" "2630.9" "3374.0" "2644.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6844923263172623256" "False" "High" "IsMasterProtein" "Q9BXP5" "Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1" "0.000" "False" "109.405" "22" "18" "32" "18" "876" "100.6" "5.96" "112.18" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04959, Pf12066" "51593" "ENSG00000087087" "SRRT" "A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4" "mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes" "" "2" "0" "0.943" "1.010" "0.951" "0.949" "0.945" "0.992" "1.007" "0.986" "0.941" "4143.6" "3906.1" "4185.5" "3939.6" "3933.5" "3913.8" "4108.6" "4170.6" "4087.3" "3898.9" "" "" "" "" "" "" "" "" "" "" "3328.1" "2818.6" "3324.7" "2639.6" "2720.4" "2936.5" "2876.6" "3045.8" "4087.3" "3170.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7462216625703255168" "False" "High" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "0.000" "False" "109.365" "17" "18" "30" "18" "1151" "131.6" "4.98" "92.63" "18" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "0.990" "0.961" "0.969" "0.965" "0.976" "0.976" "0.981" "0.927" "0.958" "2339.5" "2315.6" "2247.2" "2266.5" "2256.7" "2283.0" "2283.9" "2295.9" "2168.2" "2241.3" "" "" "" "" "" "" "" "" "" "" "1879.1" "1670.9" "1785.1" "1518.5" "1560.8" "1712.9" "1599.1" "1676.7" "2168.2" "1822.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-824304309308168891" "False" "High" "IsMasterProtein" "Q14005" "Pro-interleukin-16 OS=Homo sapiens OX=9606 GN=IL16 PE=1 SV=4" "0.000" "False" "109.335" "15" "14" "21" "14" "1332" "141.7" "8.06" "76.95" "14" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00595" "3603" "ENSG00000172349" "IL16" "A6NM20; A8MU65; B5TY35; B9EGR6; H3BVH5; hsa:3603; Q14005; Q16435; Q6VVE6; Q6ZMQ7; Q9UP18" "Other interleukin signaling" "" "1" "0" "1.003" "0.948" "1.051" "1.054" "0.995" "1.061" "1.016" "1.061" "1.036" "1330.2" "1333.8" "1260.6" "1398.3" "1402.5" "1323.6" "1411.1" "1351.2" "1411.0" "1377.5" "" "" "" "" "" "" "" "" "" "" "1068.4" "962.5" "1001.3" "936.8" "970.0" "993.0" "988.0" "986.8" "1411.0" "1120.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418505594273786343" "False" "High" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "0.000" "False" "109.299" "33" "13" "26" "12" "452" "50.9" "8.69" "95.09" "13" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.990" "0.976" "0.931" "0.971" "0.989" "0.959" "0.966" "0.955" "0.942" "2312.4" "2289.1" "2257.2" "2153.6" "2246.3" "2287.3" "2217.9" "2234.5" "2209.4" "2177.9" "" "" "" "" "" "" "" "" "" "" "1857.3" "1651.8" "1792.9" "1442.9" "1553.6" "1716.1" "1552.9" "1631.9" "2209.4" "1771.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692075332981007833" "False" "High" "IsMasterProtein" "Q13451" "Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2" "0.000" "False" "108.774" "42" "19" "33" "19" "457" "51.2" "5.90" "119.62" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00254, Pf00515" "2289" "ENSG00000096060" "FKBP5" "F5H7R1; hsa:2289; Q13451; Q59EB8; Q5TGM6" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; ESR-mediated signaling; MECP2 regulates neuronal receptors and channels" "Androgen receptor network in prostate cancer; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; MECP2 and associated Rett syndrome" "7" "0" "0.964" "0.980" "0.948" "0.943" "0.952" "0.923" "0.924" "0.926" "0.940" "4319.0" "4164.8" "4233.3" "4094.2" "4072.4" "4111.3" "3987.7" "3992.1" "3998.4" "4060.5" "" "" "" "" "" "" "" "" "" "" "3469.0" "3005.2" "3362.7" "2743.1" "2816.5" "3084.7" "2792.0" "2915.5" "3998.4" "3302.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4323681854308555372" "False" "High" "IsMasterProtein" "Q12830" "Nucleosome-remodeling factor subunit BPTF OS=Homo sapiens OX=9606 GN=BPTF PE=1 SV=3" "0.000" "False" "108.733" "9" "25" "31" "25" "3046" "338.1" "6.54" "91.70" "25" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf15613" "2186" "ENSG00000171634" "BPTF" "hsa:2186; Q12830; Q6NX67; Q7Z7D6; Q9UIG2" "" "Endoderm differentiation; 16p11.2 proximal deletion syndrome" "2" "0" "1.006" "1.031" "1.005" "0.947" "0.912" "0.950" "1.133" "1.062" "1.013" "1474.4" "1482.7" "1519.7" "1481.3" "1395.6" "1344.3" "1401.3" "1670.0" "1565.9" "1494.1" "" "" "" "" "" "" "" "" "" "" "1184.2" "1069.9" "1207.2" "992.5" "965.2" "1008.6" "981.1" "1219.6" "1565.9" "1215.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3820767575237366491" "False" "High" "IsMasterProtein" "Q9HAU5" "Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1" "0.000" "False" "108.477" "22" "28" "33" "28" "1272" "147.7" "5.69" "105.25" "28" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02854, Pf04050" "26019" "ENSG00000151461" "UPF2" "A6NLJ5; D3DRS0; hsa:26019; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9HAU5; Q9NWL1; Q9P2D9; Q9Y4M9" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "2" "0" "1.019" "1.013" "1.033" "1.023" "1.054" "1.020" "1.041" "1.047" "1.056" "2412.7" "2458.7" "2444.1" "2492.0" "2468.9" "2544.0" "2460.1" "2510.9" "2526.4" "2548.4" "" "" "" "" "" "" "" "" "" "" "1937.8" "1774.2" "1941.5" "1669.6" "1707.5" "1908.7" "1722.4" "1833.7" "2526.4" "2072.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233128446451314475" "False" "High" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "0.000" "False" "108.443" "47" "14" "35" "14" "361" "40.8" "5.25" "134.42" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "1.035" "1.026" "1.053" "1.029" "1.066" "0.953" "0.990" "1.017" "1.025" "813.3" "841.4" "834.3" "856.5" "836.5" "867.1" "774.8" "805.1" "827.1" "833.8" "" "" "" "" "" "" "" "" "" "" "653.2" "607.2" "662.7" "573.8" "578.5" "650.6" "542.5" "588.0" "827.1" "678.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "997292728151378108" "False" "High" "IsMasterProtein" "P32519" "ETS-related transcription factor Elf-1 OS=Homo sapiens OX=9606 GN=ELF1 PE=1 SV=2" "0.000" "False" "108.410" "25" "11" "23" "11" "619" "67.5" "5.21" "92.75" "11" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1997" "ENSG00000120690" "ELF1" "B4E2I5; E9PDQ9; hsa:1997; P32519; Q8N6F6; Q9UDE1" "RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling" "" "2" "0" "0.990" "1.003" "0.979" "1.018" "0.993" "0.872" "0.944" "0.926" "1.013" "1777.1" "1758.5" "1782.8" "1739.7" "1808.3" "1764.8" "1549.4" "1677.0" "1645.3" "1800.5" "" "" "" "" "" "" "" "" "" "" "1427.4" "1268.9" "1416.2" "1165.6" "1250.6" "1324.1" "1084.8" "1224.7" "1645.3" "1464.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167076474534668157" "False" "High" "IsMasterProtein" "Q15398" "Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2" "0.000" "False" "108.285" "31" "21" "28" "21" "846" "95.1" "9.00" "93.59" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf03359" "9787" "ENSG00000126787" "DLGAP5" "A8MTM6; B4DRM8; hsa:9787; Q15398; Q86T11; Q8NG58" "NOTCH3 Intracellular Domain Regulates Transcription" "Complement system in neuronal development and plasticity" "2" "0" "1.022" "0.983" "1.059" "1.021" "1.006" "1.005" "1.015" "0.984" "1.061" "2001.3" "2046.0" "1966.9" "2119.6" "2044.1" "2012.9" "2010.7" "2031.6" "1968.9" "2123.0" "" "" "" "" "" "" "" "" "" "" "1607.5" "1476.3" "1562.4" "1420.1" "1413.7" "1510.2" "1407.8" "1483.7" "1968.9" "1726.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964393919908826502" "False" "High" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "0.000" "False" "108.092" "40" "15" "26" "15" "432" "46.5" "6.39" "91.23" "15" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "Mitochondrial protein degradation; Citric acid cycle (TCA cycle)" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "5" "0" "0.994" "0.969" "0.976" "0.976" "0.976" "0.938" "0.919" "0.936" "0.943" "2859.4" "2841.2" "2772.1" "2791.8" "2790.8" "2791.9" "2682.6" "2627.0" "2676.2" "2696.7" "" "" "" "" "" "" "" "" "" "" "2296.7" "2050.1" "2201.9" "1870.5" "1930.2" "2094.7" "1878.2" "1918.5" "2676.2" "2193.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8408211072324921186" "False" "High" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "0.000" "False" "108.091" "27" "22" "44" "22" "907" "102.3" "7.14" "118.45" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "ISG15 antiviral mechanism" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "4" "0" "1.009" "0.993" "1.028" "1.012" "0.996" "1.039" "1.047" "1.020" "1.020" "3116.0" "3143.2" "3093.1" "3203.6" "3152.3" "3102.4" "3238.4" "3263.0" "3177.6" "3177.0" "" "" "" "" "" "" "" "" "" "" "2502.7" "2268.0" "2457.0" "2146.4" "2180.2" "2327.7" "2267.4" "2383.0" "3177.6" "2583.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836075231128367811" "False" "High" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "0.000" "False" "108.089" "43" "19" "41" "19" "389" "45.5" "5.62" "127.58" "19" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602, Pf21154" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "ABC-family proteins mediated transport; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neutrophil degranulation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.009" "1.010" "1.039" "1.082" "1.047" "1.076" "1.099" "1.027" "1.055" "3117.6" "3147.2" "3148.6" "3238.4" "3372.6" "3263.4" "3354.0" "3427.5" "3202.2" "3290.5" "" "" "" "" "" "" "" "" "" "" "2504.0" "2270.9" "2501.0" "2169.7" "2332.5" "2448.5" "2348.3" "2503.1" "3202.2" "2675.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2598946853791074460" "False" "High" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "0.000" "False" "108.020" "43" "14" "27" "13" "367" "40.5" "8.90" "88.08" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "Protein hydroxylation" "" "1" "1" "1.017" "0.958" "1.028" "0.988" "0.990" "0.985" "1.024" "1.003" "1.007" "1591.8" "1618.1" "1524.2" "1636.3" "1572.9" "1576.4" "1567.2" "1630.7" "1596.0" "1603.0" "" "" "" "" "" "" "" "" "" "" "1278.5" "1167.6" "1210.7" "1096.3" "1087.8" "1182.8" "1097.3" "1190.9" "1596.0" "1303.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852807762900550805" "False" "High" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "0.000" "False" "107.890" "48" "8" "30" "8" "264" "29.2" "5.97" "104.69" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "Regulation of expression of SLITs and ROBOs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.884" "0.985" "0.891" "1.015" "1.005" "0.944" "0.989" "0.937" "0.970" "1165.2" "1029.6" "1147.3" "1038.4" "1182.7" "1171.2" "1100.1" "1152.4" "1091.6" "1130.2" "" "" "" "" "" "" "" "" "" "" "935.9" "743.0" "911.3" "695.7" "818.0" "878.7" "770.2" "841.6" "1091.6" "919.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359022296663299879" "False" "High" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "0.000" "False" "107.852" "40" "19" "29" "19" "630" "70.9" "8.09" "100.82" "19" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "ISG15 antiviral mechanism; Interferon gamma signaling; RSV-host interactions; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "19" "0" "0.966" "0.965" "0.943" "0.957" "0.954" "0.986" "0.984" "0.998" "0.964" "2248.2" "2172.0" "2168.6" "2119.9" "2152.4" "2143.8" "2215.7" "2212.3" "2242.6" "2168.1" "" "" "" "" "" "" "" "" "" "" "1805.7" "1567.2" "1722.6" "1420.3" "1488.6" "1608.5" "1551.3" "1615.7" "2242.6" "1763.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594033010686828793" "False" "High" "IsMasterProtein" "P48637" "Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1" "0.000" "False" "107.758" "42" "17" "31" "17" "474" "52.4" "5.92" "112.42" "17" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf03199, Pf03917" "2937" "ENSG00000100983" "GSS" "B2R697; B6F210; E1P5P9; hsa:2937; P48637; Q4TTD9" "Glutathione synthesis and recycling; Defective GSS causes GSS deficiency" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "8" "0" "0.963" "0.981" "0.987" "1.013" "0.987" "1.024" "0.951" "0.966" "0.989" "2674.3" "2574.8" "2623.0" "2640.0" "2709.1" "2639.1" "2739.7" "2542.6" "2582.8" "2644.6" "" "" "" "" "" "" "" "" "" "" "2148.0" "1857.9" "2083.5" "1768.8" "1873.6" "1980.1" "1918.2" "1856.8" "2582.8" "2150.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908270249902800016" "False" "High" "IsMasterProtein" "P35573" "Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3" "0.000" "False" "107.663" "19" "25" "31" "25" "1532" "174.7" "6.76" "102.25" "25" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06202, Pf14699, Pf14701, Pf14702" "178" "ENSG00000162688" "AGL" "A6NCX7; A6NEK2; D3DT51; hsa:178; P35573; P78354; P78544; Q59H92; Q6AZ90; Q9UF08" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "Glycogen synthesis and degradation" "3" "0" "1.008" "0.972" "1.055" "1.132" "1.073" "1.137" "0.977" "1.064" "1.104" "1905.9" "1922.1" "1852.3" "2010.4" "2157.4" "2044.2" "2166.4" "1861.5" "2027.9" "2104.5" "" "" "" "" "" "" "" "" "" "" "1530.8" "1386.9" "1471.3" "1347.0" "1492.1" "1533.8" "1516.8" "1359.4" "2027.9" "1711.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100878916131084887" "False" "High" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "0.000" "False" "107.507" "34" "18" "27" "18" "562" "61.4" "6.76" "93.19" "18" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Galactose catabolism; Defective PGM1 causes PGM1-CDG" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "13" "0" "0.978" "1.018" "1.002" "0.980" "0.993" "0.978" "0.981" "0.962" "0.961" "2906.0" "2841.0" "2959.4" "2913.0" "2847.6" "2885.0" "2841.6" "2850.3" "2795.2" "2791.6" "" "" "" "" "" "" "" "" "" "" "2334.1" "2050.0" "2350.8" "1951.7" "1969.4" "2164.5" "1989.5" "2081.6" "2795.2" "2270.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7210504404319708374" "False" "High" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "0.000" "False" "107.433" "32" "13" "23" "6" "577" "60.9" "6.83" "84.41" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "1.020" "1.039" "1.158" "1.059" "1.060" "1.102" "1.054" "1.073" "1.031" "668.0" "681.6" "694.2" "773.7" "707.7" "708.0" "736.0" "704.4" "717.1" "688.5" "" "" "" "" "" "" "" "" "" "" "536.5" "491.9" "551.4" "518.4" "489.4" "531.2" "515.3" "514.4" "717.1" "559.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3690320084066520669" "False" "High" "IsMasterProtein" "Cont_P04259" "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" "0.000" "True" "107.388" "32" "22" "40" "2" "564" "60.0" "8.00" "115.38" "22" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3854" "ENSG00000185479" "KRT6B" "hsa:3854; P04259; P48669" "Formation of the cornified envelope" "" "2" "0" "0.381" "0.133" "0.606" "0.243" "0.174" "0.378" "0.199" "0.260" "0.294" "827.8" "315.5" "110.4" "501.7" "200.9" "144.3" "313.3" "164.8" "215.2" "243.7" "" "" "" "" "" "" "" "" "" "" "664.9" "227.7" "87.7" "336.1" "138.9" "108.3" "219.4" "120.3" "215.2" "198.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015286030572761336" "False" "High" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "0.000" "False" "107.298" "36" "15" "41" "15" "427" "45.2" "8.85" "147.05" "15" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Branched-chain amino acid catabolism; Mitochondrial protein degradation; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "7" "0" "1.005" "0.994" "0.986" "1.070" "1.013" "1.025" "1.049" "0.979" "0.985" "3918.0" "3939.2" "3892.7" "3864.0" "4190.6" "3969.3" "4017.7" "4110.1" "3834.6" "3859.0" "" "" "" "" "" "" "" "" "" "" "3146.9" "2842.4" "3092.1" "2588.9" "2898.3" "2978.1" "2813.0" "3001.6" "3834.6" "3138.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-374289036912732411" "False" "High" "IsMasterProtein" "Q15042" "Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3" "0.000" "False" "107.281" "22" "19" "24" "19" "981" "110.5" "5.55" "75.59" "19" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf13890, Pf19533" "22930" "ENSG00000115839" "RAB3GAP1" "A6H8Z3; C9J837; hsa:22930; Q15042; Q659F5; Q8TBB4" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "" "2" "0" "1.045" "1.033" "1.009" "1.000" "0.969" "0.887" "1.047" "1.011" "1.010" "2390.8" "2497.6" "2470.5" "2411.5" "2389.8" "2316.3" "2119.6" "2503.1" "2418.2" "2414.3" "" "" "" "" "" "" "" "" "" "" "1920.2" "1802.2" "1962.4" "1615.7" "1652.8" "1737.9" "1484.1" "1828.0" "2418.2" "1963.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108024960006830899" "False" "High" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "0.000" "False" "107.178" "40" "13" "40" "13" "371" "42.4" "5.35" "126.27" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Estrogen-dependent gene expression; Extra-nuclear estrogen signaling; RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "11" "0" "0.957" "0.944" "0.942" "0.933" "0.955" "0.938" "0.922" "0.880" "0.947" "3163.0" "3027.5" "2985.2" "2980.5" "2949.7" "3020.8" "2965.5" "2915.3" "2784.6" "2995.2" "" "" "" "" "" "" "" "" "" "" "2540.5" "2184.6" "2371.2" "1997.0" "2040.1" "2266.5" "2076.3" "2129.0" "2784.6" "2435.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175952193399053833" "False" "High" "IsMasterProtein" "P50748" "Kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=KNTC1 PE=1 SV=1" "0.000" "False" "106.911" "11" "24" "28" "23" "2209" "250.6" "5.97" "96.73" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10493" "9735" "ENSG00000184445" "KNTC1" "A7E2C4; B3KSG2; hsa:9735; P50748" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "1" "1.048" "1.020" "1.053" "0.996" "1.007" "0.941" "0.999" "0.965" "1.013" "2729.5" "2860.4" "2784.4" "2873.2" "2719.7" "2748.1" "2568.3" "2727.1" "2634.1" "2765.5" "" "" "" "" "" "" "" "" "" "" "2192.3" "2064.0" "2211.8" "1925.0" "1881.0" "2061.9" "1798.2" "1991.6" "2634.1" "2249.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939366548436887845" "False" "High" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "0.000" "False" "106.830" "45" "17" "24" "17" "403" "47.3" "9.36" "86.21" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "" "3" "0" "1.021" "1.012" "1.054" "1.024" "0.965" "0.951" "1.022" "0.981" "1.001" "2330.8" "2380.3" "2357.8" "2455.7" "2386.4" "2250.3" "2215.5" "2381.6" "2287.6" "2333.3" "" "" "" "" "" "" "" "" "" "" "1872.1" "1717.5" "1872.8" "1645.3" "1650.5" "1688.3" "1551.2" "1739.3" "2287.6" "1897.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051331415144919391" "False" "High" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "0.000" "False" "106.809" "30" "13" "37" "13" "494" "53.8" "5.87" "108.37" "13" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "Carnitine synthesis" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "4" "0" "0.980" "0.994" "1.012" "0.980" "0.937" "0.999" "0.970" "0.965" "0.968" "3337.1" "3269.6" "3315.7" "3375.8" "3269.8" "3127.1" "3332.7" "3236.1" "3220.6" "3229.7" "" "" "" "" "" "" "" "" "" "" "2680.3" "2359.2" "2633.7" "2261.8" "2261.4" "2346.2" "2333.4" "2363.3" "3220.6" "2626.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4807008432777767819" "False" "High" "IsMasterProtein" "Q9NTZ6" "RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1" "0.000" "False" "106.795" "21" "17" "42" "17" "932" "97.3" "8.63" "111.78" "17" "other biological processes" "nucleus;other cell component" "" "Pf00076" "10137" "ENSG00000244462" "RBM12" "B3KRU2; E1P5R6; hsa:10137; O94865; Q8N3B1; Q9H196; Q9NTZ6" "" "" "0" "0" "1.005" "1.013" "0.988" "0.973" "0.958" "0.930" "0.956" "0.978" "0.994" "2741.2" "2753.7" "2776.9" "2707.4" "2665.9" "2626.4" "2548.0" "2621.2" "2681.4" "2725.7" "" "" "" "" "" "" "" "" "" "" "2201.7" "1987.0" "2205.8" "1814.0" "1843.8" "1970.6" "1784.0" "1914.3" "2681.4" "2216.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6837951581036984725" "False" "High" "IsMasterProtein" "P33241" "Lymphocyte-specific protein 1 OS=Homo sapiens OX=9606 GN=LSP1 PE=1 SV=1" "0.000" "False" "106.540" "47" "11" "30" "11" "339" "37.2" "4.74" "110.92" "11" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton" "cytoskeletal activity" "Pf02029" "4046" "ENSG00000130592; ENSG00000288199" "LSP1" "B3KPP1; B3KRR6; E9PBV6; E9PFP3; hsa:4046; P33241; Q16096; Q53H48; Q6FHM3; Q9BUY8" "" "" "0" "0" "0.950" "1.039" "1.064" "0.971" "1.091" "1.113" "1.038" "0.998" "1.023" "2676.6" "2543.7" "2781.7" "2847.4" "2598.7" "2918.9" "2978.6" "2778.0" "2671.1" "2737.1" "" "" "" "" "" "" "" "" "" "" "2149.8" "1835.5" "2209.6" "1907.8" "1797.3" "2190.0" "2085.5" "2028.8" "2671.1" "2225.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2410269861090895387" "False" "High" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "0.000" "False" "106.530" "20" "11" "18" "11" "677" "73.3" "4.84" "76.38" "11" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "1.016" "1.057" "1.048" "1.080" "1.048" "1.078" "1.135" "1.186" "1.092" "1288.7" "1309.6" "1361.8" "1351.0" "1392.2" "1351.1" "1389.0" "1463.0" "1528.0" "1407.1" "" "" "" "" "" "" "" "" "" "" "1035.1" "945.0" "1081.7" "905.2" "962.8" "1013.7" "972.5" "1068.4" "1528.0" "1144.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4388967430464997560" "False" "High" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "0.000" "False" "106.525" "43" "14" "28" "13" "410" "46.6" "7.37" "108.98" "14" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "AURKA Activation by TPX2; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "18" "1" "0.940" "0.990" "0.938" "0.932" "0.965" "0.923" "0.947" "0.938" "0.933" "4556.7" "4282.9" "4511.9" "4274.4" "4248.7" "4397.5" "4204.0" "4317.2" "4275.8" "4253.3" "" "" "" "" "" "" "" "" "" "" "3659.9" "3090.4" "3584.0" "2863.8" "2938.5" "3299.4" "2943.4" "3152.9" "4275.8" "3459.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896567990825277729" "False" "High" "IsMasterProtein" "O94925" "Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1" "0.000" "False" "106.321" "23" "12" "23" "12" "669" "73.4" "7.77" "90.64" "12" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf04960, Pf12796, Pf17959" "2744" "ENSG00000115419" "GLS" "hsa:2744; O94925; Q9UL05; Q9UL06; Q9UL07; Q9UN40" "Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells; Cell lineage map for neuronal differentiation" "8" "0" "1.015" "0.975" "0.980" "1.020" "0.989" "0.984" "1.033" "1.048" "1.004" "2127.9" "2160.5" "2074.3" "2086.1" "2171.3" "2104.4" "2094.0" "2197.4" "2229.9" "2137.2" "" "" "" "" "" "" "" "" "" "" "1709.1" "1559.0" "1647.7" "1397.7" "1501.7" "1578.9" "1466.1" "1604.8" "2229.9" "1738.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7900354501110065761" "False" "High" "IsMasterProtein" "O00170" "AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3" "0.000" "False" "106.270" "48" "12" "24" "12" "330" "37.6" "6.42" "88.71" "12" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "9049" "ENSG00000110711" "AIP" "A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; hsa:9049; O00170; Q2M3Q2; Q99606" "Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "5" "0" "1.025" "0.980" "1.033" "1.016" "0.948" "1.157" "1.040" "0.977" "0.995" "1538.0" "1576.3" "1507.1" "1588.9" "1562.5" "1458.0" "1779.5" "1599.2" "1502.4" "1530.7" "" "" "" "" "" "" "" "" "" "" "1235.3" "1137.4" "1197.1" "1064.6" "1080.6" "1093.9" "1245.9" "1167.9" "1502.4" "1244.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2799145337949175211" "False" "High" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "0.000" "False" "106.189" "21" "19" "24" "19" "1046" "116.9" "6.70" "88.02" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "8" "0" "1.015" "1.054" "1.025" "1.092" "1.062" "0.932" "1.014" "0.966" "1.054" "1523.7" "1546.3" "1606.0" "1561.3" "1663.9" "1618.0" "1420.1" "1544.5" "1472.5" "1606.0" "" "" "" "" "" "" "" "" "" "" "1223.8" "1115.7" "1275.7" "1046.1" "1150.8" "1214.0" "994.3" "1128.0" "1472.5" "1306.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5911471042018297925" "False" "High" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "0.000" "False" "106.131" "33" "11" "21" "11" "463" "50.5" "9.52" "83.68" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "0" "1.042" "1.029" "0.983" "1.031" "1.027" "0.996" "1.036" "1.025" "1.019" "1871.8" "1950.8" "1926.0" "1840.3" "1929.3" "1922.7" "1865.2" "1939.5" "1918.9" "1906.7" "" "" "" "" "" "" "" "" "" "" "1503.4" "1407.7" "1529.9" "1233.0" "1334.3" "1442.6" "1305.9" "1416.4" "1918.9" "1550.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3688625229951110619" "False" "High" "IsMasterProtein" "Cont_P02538" "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" "0.000" "True" "105.947" "32" "22" "39" "2" "564" "60.0" "8.00" "112.54" "22" "cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3853" "ENSG00000205420" "KRT6A" "A0A0S2Z428; A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4" "Formation of the cornified envelope" "Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes" "5" "7" "0.387" "0.066" "0.263" "0.150" "0.135" "0.357" "0.125" "0.185" "0.265" "7619.4" "2949.1" "504.6" "2001.0" "1142.6" "1027.1" "2721.5" "955.6" "1412.9" "2017.2" "" "" "" "" "" "" "" "" "" "" "6119.8" "2128.0" "400.8" "1340.7" "790.3" "770.6" "1905.5" "697.9" "1412.9" "1640.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5216339322949848557" "False" "High" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "0.000" "False" "105.609" "29" "17" "26" "17" "661" "75.0" "6.37" "84.97" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.990" "0.981" "1.000" "0.988" "0.979" "0.949" "0.954" "0.890" "0.994" "2599.2" "2572.4" "2549.1" "2599.0" "2568.7" "2544.5" "2467.8" "2480.3" "2312.6" "2583.8" "" "" "" "" "" "" "" "" "" "" "2087.7" "1856.1" "2024.8" "1741.3" "1776.5" "1909.1" "1727.8" "1811.4" "2312.6" "2101.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7171410217774938332" "False" "High" "IsMasterProtein" "Q96T51" "RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2" "0.000" "False" "105.404" "31" "20" "31" "20" "708" "79.8" "5.74" "96.20" "20" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "80230" "ENSG00000176783; ENSG00000284260" "RUFY1" "hsa:80230; Q59FF3; Q71S93; Q96T51; Q9H6I3" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "0.989" "0.969" "1.003" "1.038" "0.970" "0.950" "0.967" "1.010" "1.038" "1816.2" "1796.8" "1759.5" "1821.9" "1885.2" "1761.8" "1725.9" "1756.6" "1835.0" "1885.7" "" "" "" "" "" "" "" "" "" "" "1458.8" "1296.5" "1397.6" "1220.7" "1303.8" "1321.9" "1208.4" "1282.9" "1835.0" "1533.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7160695848866474340" "False" "High" "IsMasterProtein" "Q96JG6" "Syndetin OS=Homo sapiens OX=9606 GN=VPS50 PE=1 SV=3" "0.000" "False" "104.953" "22" "16" "20" "16" "964" "111.1" "6.20" "78.65" "16" "transport" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf10474, Pf10475" "55610" "ENSG00000004766" "VPS50" "B3KX22; D1MQ00; F5H5U7; hsa:55610; Q75N07; Q8WVK3; Q96JG6; Q9H5C6" "" "" "0" "0" "0.957" "0.895" "1.055" "1.005" "0.964" "1.014" "0.926" "0.959" "0.970" "575.2" "550.6" "514.9" "606.8" "577.9" "554.5" "583.1" "532.6" "551.6" "558.0" "" "" "" "" "" "" "" "" "" "" "462.0" "397.3" "409.0" "406.6" "399.7" "416.1" "408.3" "388.9" "551.6" "453.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "657128700828351651" "False" "High" "IsMasterProtein" "Q16643" "Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4" "0.000" "False" "104.952" "27" "16" "27" "16" "649" "71.4" "4.45" "92.72" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "1627" "ENSG00000113758" "DBN1" "A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOH GTPase cycle; RHOD GTPase cycle" "5q35 copy number variation" "5" "0" "0.871" "1.009" "0.911" "0.836" "0.993" "0.982" "0.992" "1.011" "0.958" "1928.3" "1678.7" "1946.6" "1756.9" "1612.7" "1914.9" "1894.4" "1912.2" "1949.5" "1847.1" "" "" "" "" "" "" "" "" "" "" "1548.8" "1211.3" "1546.2" "1177.1" "1115.4" "1436.7" "1326.4" "1396.5" "1949.5" "1502.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538896593466497334" "False" "High" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "0.000" "False" "104.880" "54" "11" "91" "10" "166" "18.5" "8.09" "293.17" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Platelet degranulation ; Regulation of actin dynamics for phagocytic cup formation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "15" "1" "1.027" "1.032" "0.991" "1.059" "1.100" "1.041" "1.068" "1.077" "1.050" "7795.9" "8005.0" "8048.6" "7724.9" "8258.8" "8579.1" "8118.3" "8329.8" "8395.7" "8185.7" "" "" "" "" "" "" "" "" "" "" "6261.6" "5776.2" "6393.2" "5175.7" "5711.8" "6436.7" "5684.0" "6083.3" "8395.7" "6656.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288023909312929848" "False" "High" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "0.000" "False" "104.791" "34" "18" "60" "11" "558" "63.1" "8.32" "174.38" "18" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "Glycolysis; Gluconeogenesis; Neutrophil degranulation; TP53 Regulates Metabolic Genes" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "13" "5" "0.969" "1.004" "0.984" "0.996" "1.006" "0.989" "0.965" "0.893" "0.976" "6400.0" "6200.5" "6428.3" "6299.9" "6374.6" "6440.7" "6330.1" "6175.0" "5712.7" "6247.3" "" "" "" "" "" "" "" "" "" "" "5140.4" "4474.1" "5106.2" "4221.0" "4408.7" "4832.3" "4432.0" "4509.6" "5712.7" "5080.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905591351439676835" "False" "High" "IsMasterProtein" "P50995" "Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1" "0.000" "False" "104.713" "39" "18" "36" "18" "505" "54.4" "7.65" "107.34" "18" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00191" "311" "ENSG00000122359" "ANXA11" "B4DVE7; hsa:311; P50995" "" "" "0" "0" "1.002" "1.041" "1.027" "1.016" "0.972" "1.000" "0.993" "1.018" "1.031" "1725.2" "1729.2" "1795.1" "1772.0" "1753.2" "1676.9" "1724.5" "1712.6" "1756.5" "1778.3" "" "" "" "" "" "" "" "" "" "" "1385.7" "1247.7" "1425.9" "1187.2" "1212.5" "1258.1" "1207.4" "1250.7" "1756.5" "1446.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9156757260988577689" "False" "High" "IsMasterProtein" "P0DJD0" "RANBP2-like and GRIP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RGPD1 PE=2 SV=1" "0.000" "False" "104.545" "12" "19" "28" "1" "1748" "196.5" "6.14" "97.63" "19" "transport" "nucleus;other cell component" "" "Pf00638, Pf01465, Pf16704" "400966" "" "RGPD1" "hsa:400966; P0C839; P0DJD0; Q68DN6; Q6V1X0" "" "" "0" "0" "1.051" "1.079" "1.157" "1.099" "1.017" "1.082" "1.139" "1.199" "1.085" "176.6" "185.6" "190.6" "204.4" "194.1" "179.6" "191.1" "201.2" "211.8" "191.6" "" "" "" "" "" "" "" "" "" "" "141.9" "133.9" "151.4" "137.0" "134.3" "134.7" "133.8" "146.9" "211.8" "155.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551881844425109656" "False" "High" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "0.000" "False" "104.543" "38" "16" "31" "16" "536" "61.5" "9.52" "103.51" "16" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "16" "0" "1.027" "1.048" "0.992" "1.040" "1.051" "0.963" "0.993" "1.048" "1.039" "2870.8" "2947.4" "3009.6" "2848.0" "2985.2" "3017.7" "2765.7" "2849.7" "3007.1" "2983.0" "" "" "" "" "" "" "" "" "" "" "2305.8" "2126.8" "2390.6" "1908.1" "2064.6" "2264.1" "1936.4" "2081.1" "3007.1" "2425.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6985960340352969870" "False" "High" "IsMasterProtein" "P62714" "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1" "0.000" "False" "104.332" "58" "12" "39" "1" "309" "35.6" "5.43" "126.62" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00149" "5516" "ENSG00000104695" "PPP2CB" "D3DSV4; hsa:5516; P11082; P62714; Q6FHK5" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RAF activation; Negative regulation of MAPK pathway; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Serotonin transporter activity; Dopamine metabolism; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; Exercise-induced circadian regulation; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Monoamine transport" "45" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951583387108982266" "False" "High" "IsMasterProtein" "P11171" "Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4" "0.000" "False" "104.274" "31" "23" "32" "23" "864" "97.0" "5.58" "105.49" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2035" "ENSG00000159023" "EPB41" "B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579" "Neurexins and neuroligins" "VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway" "4" "0" "0.976" "0.981" "0.983" "0.961" "1.031" "0.960" "0.980" "0.976" "0.975" "2249.9" "2195.4" "2206.5" "2211.5" "2162.9" "2320.7" "2160.7" "2205.1" "2196.1" "2193.4" "" "" "" "" "" "" "" "" "" "" "1807.1" "1584.1" "1752.7" "1481.7" "1495.9" "1741.2" "1512.8" "1610.4" "2196.1" "1783.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220209801310809840" "False" "High" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "0.000" "False" "103.999" "42" "12" "27" "7" "318" "34.8" "6.98" "100.22" "12" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "5" "1.038" "1.024" "0.980" "1.083" "1.070" "1.067" "1.036" "1.078" "1.031" "2045.7" "2124.0" "2094.8" "2004.7" "2215.5" "2189.8" "2182.8" "2119.5" "2205.3" "2109.1" "" "" "" "" "" "" "" "" "" "" "1643.1" "1532.6" "1664.0" "1343.2" "1532.3" "1643.0" "1528.3" "1547.9" "2205.3" "1715.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870726190365747871" "False" "High" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "0.000" "False" "103.974" "39" "13" "29" "13" "394" "44.7" "6.74" "112.09" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "8" "0" "0.962" "0.959" "0.962" "0.939" "0.924" "0.945" "0.954" "0.902" "0.949" "3080.1" "2964.6" "2955.0" "2962.6" "2893.1" "2844.9" "2911.9" "2939.5" "2777.6" "2921.8" "" "" "" "" "" "" "" "" "" "" "2473.9" "2139.1" "2347.3" "1985.0" "2000.9" "2134.5" "2038.8" "2146.7" "2777.6" "2376.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834517730795482410" "False" "High" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "0.000" "False" "103.969" "32" "20" "30" "20" "676" "77.5" "7.75" "102.62" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf21494" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Interferon gamma signaling; Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; VEGFR2 mediated cell proliferation; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "47" "0" "1.013" "0.982" "0.954" "0.978" "1.000" "0.924" "0.935" "0.972" "0.979" "2174.7" "2203.9" "2135.8" "2074.4" "2126.8" "2174.6" "2009.5" "2034.2" "2114.6" "2129.7" "" "" "" "" "" "" "" "" "" "" "1746.7" "1590.3" "1696.5" "1389.9" "1470.9" "1631.5" "1407.0" "1485.6" "2114.6" "1731.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5301300435928167882" "False" "High" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "0.000" "False" "103.757" "51" "9" "36" "7" "286" "32.9" "5.85" "144.44" "9" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "" "7" "0" "0.971" "0.977" "0.995" "0.994" "1.008" "0.987" "0.930" "0.896" "1.003" "1267.4" "1231.2" "1238.7" "1261.6" "1260.1" "1277.4" "1251.2" "1179.1" "1136.1" "1271.1" "" "" "" "" "" "" "" "" "" "" "1018.0" "888.4" "983.9" "845.3" "871.5" "958.4" "876.0" "861.1" "1136.1" "1033.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1231047339708811007" "False" "High" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "0.000" "False" "103.623" "19" "19" "34" "18" "1094" "121.2" "6.04" "112.85" "19" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "" "2" "0" "1.001" "1.003" "0.978" "0.978" "0.967" "0.915" "0.971" "0.971" "0.977" "2702.0" "2703.4" "2709.3" "2641.6" "2642.0" "2612.6" "2472.9" "2622.4" "2623.0" "2640.7" "" "" "" "" "" "" "" "" "" "" "2170.2" "1950.7" "2152.1" "1769.8" "1827.2" "1960.2" "1731.4" "1915.2" "2623.0" "2147.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-560084501499272066" "False" "High" "IsMasterProtein" "Q8IY18" "Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2" "0.000" "False" "103.420" "21" "22" "28" "22" "1101" "128.7" "8.38" "86.46" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "23137" "ENSG00000198887" "SMC5" "A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "1.004" "0.958" "0.984" "0.986" "0.977" "0.927" "0.972" "0.969" "0.997" "1851.9" "1859.1" "1774.6" "1822.9" "1825.2" "1808.6" "1717.6" "1799.6" "1794.2" "1847.0" "" "" "" "" "" "" "" "" "" "" "1487.5" "1341.4" "1409.6" "1221.3" "1262.3" "1356.9" "1202.6" "1314.3" "1794.2" "1502.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7021380242978739287" "False" "High" "IsMasterProtein" "Q92797" "Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2" "0.000" "False" "103.207" "21" "23" "30" "23" "1274" "141.1" "6.13" "98.71" "23" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf11935, Pf12295" "8189" "ENSG00000125755" "SYMPK" "hsa:8189; O00521; O00689; O00733; Q59GT5; Q8N2U5; Q92797" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "" "5" "0" "1.028" "1.031" "1.019" "1.063" "1.022" "1.021" "1.062" "1.058" "1.047" "2141.5" "2200.8" "2207.5" "2181.7" "2276.0" "2188.1" "2186.9" "2274.7" "2265.6" "2241.4" "" "" "" "" "" "" "" "" "" "" "1720.0" "1588.1" "1753.5" "1461.8" "1574.1" "1641.7" "1531.2" "1661.2" "2265.6" "1822.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010508153477037857" "False" "High" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "0.000" "False" "103.182" "35" "12" "55" "10" "355" "38.4" "7.81" "172.39" "12" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "1.021" "1.041" "1.075" "1.022" "1.018" "0.983" "0.988" "1.012" "1.042" "2981.6" "3043.3" "3104.4" "3206.7" "3046.5" "3036.1" "2931.9" "2947.0" "3018.6" "3107.3" "" "" "" "" "" "" "" "" "" "" "2394.8" "2196.0" "2465.9" "2148.5" "2107.0" "2277.9" "2052.8" "2152.2" "3018.6" "2527.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5999519850232784779" "False" "High" "IsMasterProtein" "Q9Y3L3" "SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3" "0.000" "False" "103.068" "30" "17" "25" "17" "701" "75.7" "6.77" "88.08" "17" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "23616" "ENSG00000100092" "SH3BP1" "hsa:23616; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9; Q9Y3L3" "RAC1 GTPase cycle" "" "1" "0" "0.988" "0.987" "1.005" "0.966" "0.938" "0.989" "1.013" "1.028" "0.995" "2619.3" "2589.0" "2585.1" "2632.5" "2529.7" "2457.0" "2591.2" "2652.6" "2692.5" "2606.2" "" "" "" "" "" "" "" "" "" "" "2103.8" "1868.2" "2053.4" "1763.8" "1749.6" "1843.4" "1814.2" "1937.2" "2692.5" "2119.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3995603134814959224" "False" "High" "IsMasterProtein" "Q9NRL2" "Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens OX=9606 GN=BAZ1A PE=1 SV=2" "0.000" "False" "102.953" "16" "24" "26" "24" "1556" "178.6" "6.60" "83.40" "24" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf10537, Pf15612, Pf15613" "11177" "ENSG00000198604" "BAZ1A" "hsa:11177; Q9NRL2; Q9NZ15; Q9P065; Q9UIG1; Q9Y3V3" "" "Ectoderm differentiation" "1" "0" "1.010" "1.064" "1.085" "1.027" "1.055" "1.050" "1.095" "1.136" "1.084" "1868.9" "1886.8" "1989.2" "2028.3" "1919.2" "1970.9" "1961.8" "2045.8" "2122.6" "2025.6" "" "" "" "" "" "" "" "" "" "" "1501.1" "1361.4" "1580.1" "1358.9" "1327.4" "1478.7" "1373.6" "1494.1" "2122.6" "1647.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3827413943900730422" "False" "High" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "0.000" "False" "102.919" "26" "16" "35" "16" "641" "70.0" "8.38" "116.70" "16" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "mRNA Splicing - Major Pathway" "" "1" "0" "1.043" "1.068" "0.995" "1.011" "0.997" "0.981" "1.035" "1.042" "1.017" "3790.1" "3951.8" "4049.5" "3771.9" "3833.4" "3777.5" "3719.3" "3922.0" "3949.3" "3853.7" "" "" "" "" "" "" "" "" "" "" "3044.1" "2851.5" "3216.7" "2527.2" "2651.2" "2834.2" "2604.1" "2864.2" "3949.3" "3134.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2411801021050745689" "False" "High" "IsMasterProtein" "Q9NSE4" "Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2" "0.000" "False" "102.840" "20" "19" "28" "19" "1012" "113.7" "7.20" "82.32" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00133, Pf06827, Pf08264" "55699" "ENSG00000067704" "IARS2" "B2RPG8; hsa:55699; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NSE4; Q9NW42" "Mitochondrial protein degradation; Mitochondrial tRNA aminoacylation" "" "2" "0" "1.000" "0.980" "0.987" "1.005" "0.985" "0.948" "0.923" "0.960" "0.990" "2974.4" "2974.1" "2914.3" "2935.1" "2989.0" "2931.0" "2819.0" "2744.8" "2855.7" "2944.9" "" "" "" "" "" "" "" "" "" "" "2389.0" "2146.1" "2314.9" "1966.5" "2067.2" "2199.0" "1973.7" "2004.5" "2855.7" "2394.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037912225033679960" "False" "High" "IsMasterProtein" "P47756" "F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5" "0.000" "False" "102.724" "40" "12" "45" "12" "272" "30.6" "6.00" "146.84" "12" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01115" "832" "ENSG00000077549" "CAPZB" "hsa:832; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4" "MHC class II antigen presentation; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; RHOD GTPase cycle; RHOF GTPase cycle; Factors involved in megakaryocyte development and platelet production" "VEGFA-VEGFR2 signaling" "9" "0" "0.974" "1.025" "0.974" "0.998" "1.009" "0.989" "1.006" "1.042" "0.978" "3896.4" "3796.7" "3994.6" "3793.4" "3889.9" "3929.8" "3852.2" "3919.8" "4060.0" "3811.0" "" "" "" "" "" "" "" "" "" "" "3129.6" "2739.6" "3173.0" "2541.6" "2690.3" "2948.5" "2697.1" "2862.6" "4060.0" "3099.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3509050462547548554" "False" "High" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "0.000" "False" "102.260" "53" "14" "107" "9" "246" "28.2" "4.84" "279.95" "14" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "1.018" "0.982" "0.936" "0.937" "0.973" "0.927" "0.951" "0.971" "0.980" "2252.4" "2294.0" "2212.9" "2107.6" "2110.6" "2190.5" "2088.2" "2142.8" "2186.9" "2206.6" "" "" "" "" "" "" "" "" "" "" "1809.1" "1655.3" "1757.8" "1412.1" "1459.7" "1643.5" "1462.1" "1564.9" "2186.9" "1794.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4969785199518402327" "False" "High" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "0.000" "False" "101.952" "37" "14" "28" "14" "491" "55.5" "6.74" "111.19" "14" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602, Pf21151" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "" "5" "0" "1.004" "1.030" "0.975" "1.001" "0.976" "0.967" "0.942" "0.953" "0.978" "2543.1" "2552.8" "2618.9" "2480.0" "2546.9" "2482.8" "2458.4" "2396.6" "2424.5" "2487.1" "" "" "" "" "" "" "" "" "" "" "2042.6" "1842.0" "2080.3" "1661.6" "1761.5" "1862.8" "1721.3" "1750.2" "2424.5" "2022.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "412989267492622894" "False" "High" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "0.000" "False" "101.932" "32" "13" "25" "12" "501" "58.8" "5.38" "95.65" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "mRNA Splicing - Major Pathway" "Exercise-induced circadian regulation; mRNA processing" "3" "0" "1.011" "1.015" "1.002" "0.999" "1.028" "1.023" "1.062" "1.021" "1.017" "2507.7" "2534.1" "2546.1" "2513.8" "2505.5" "2576.7" "2565.6" "2662.2" "2559.4" "2550.0" "" "" "" "" "" "" "" "" "" "" "2014.2" "1828.5" "2022.5" "1684.3" "1732.8" "1933.3" "1796.3" "1944.2" "2559.4" "2073.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3977231737757699064" "False" "High" "IsMasterProtein" "Q6JBY9" "CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1" "0.000" "False" "101.784" "38" "13" "24" "13" "416" "44.5" "5.40" "105.61" "13" "stress response;transport;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05177, Pf15255" "92241" "ENSG00000198771" "RCSD1" "B1AK48; hsa:92241; Q4G0E7; Q6IN93; Q6JBY9; Q8IZM2; Q96DX0; Q9NST4" "" "" "0" "0" "1.066" "1.074" "1.121" "1.049" "1.038" "1.003" "0.984" "0.963" "1.014" "2211.6" "2357.7" "2375.3" "2479.6" "2319.2" "2296.0" "2218.8" "2176.9" "2130.7" "2241.8" "" "" "" "" "" "" "" "" "" "" "1776.4" "1701.3" "1886.8" "1661.3" "1604.0" "1722.7" "1553.5" "1589.8" "2130.7" "1823.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5704352961259904218" "False" "High" "IsMasterProtein" "Q14155" "Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2" "0.000" "False" "101.675" "22" "14" "19" "12" "803" "90.0" "7.09" "77.66" "14" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16614, Pf16615" "8874" "ENSG00000102606" "ARHGEF7" "B1ALK6; B1ALK8; hsa:8874; Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1" "RHOV GTPase cycle; RHOU GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOJ GTPase cycle; Ephrin signaling; RHOQ GTPase cycle; EGFR downregulation" "Integrin-mediated cell adhesion; CAMKK2 pathway; Regulation of actin cytoskeleton" "14" "0" "1.002" "1.006" "0.994" "0.957" "0.924" "0.930" "0.957" "0.971" "0.944" "1622.7" "1626.3" "1632.4" "1613.7" "1553.7" "1499.5" "1509.7" "1553.7" "1574.9" "1531.4" "" "" "" "" "" "" "" "" "" "" "1303.3" "1173.5" "1296.7" "1081.2" "1074.5" "1125.0" "1057.0" "1134.6" "1574.9" "1245.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951553745667677229" "False" "High" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "0.000" "False" "101.643" "38" "11" "23" "11" "397" "44.8" "7.08" "87.43" "11" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; HDAC6 interactions in the central nervous system" "4" "0" "1.065" "1.056" "0.973" "1.036" "1.081" "1.074" "1.175" "1.203" "1.067" "1875.6" "1997.9" "1980.4" "1824.1" "1942.4" "2027.4" "2014.0" "2202.9" "2255.6" "2001.5" "" "" "" "" "" "" "" "" "" "" "1506.4" "1441.7" "1573.1" "1222.2" "1343.4" "1521.1" "1410.1" "1608.8" "2255.6" "1627.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819248738273411506" "False" "High" "IsMasterProtein" "O14981" "TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2" "0.000" "False" "101.605" "12" "18" "23" "18" "1849" "206.8" "6.52" "80.97" "18" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf12054" "9044" "ENSG00000095564" "BTAF1" "B4E0W6; hsa:9044; O14981; O43578" "" "" "0" "0" "1.096" "1.009" "1.037" "1.022" "1.036" "1.009" "1.072" "1.070" "1.004" "1500.1" "1643.4" "1513.3" "1555.0" "1532.5" "1553.7" "1513.7" "1607.9" "1605.8" "1506.7" "" "" "" "" "" "" "" "" "" "" "1204.9" "1185.8" "1202.1" "1041.8" "1059.9" "1165.7" "1059.8" "1174.3" "1605.8" "1225.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3104846382151978420" "False" "High" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "0.000" "False" "101.600" "37" "9" "36" "9" "258" "27.3" "6.40" "149.64" "9" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "1.035" "1.044" "1.037" "1.015" "1.064" "0.992" "1.006" "1.067" "1.001" "4556.5" "4717.1" "4755.2" "4725.2" "4622.9" "4846.0" "4519.1" "4583.5" "4861.4" "4559.4" "" "" "" "" "" "" "" "" "" "" "3659.7" "3403.7" "3777.2" "3165.9" "3197.2" "3635.8" "3164.1" "3347.3" "4861.4" "3707.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8832352295829315313" "False" "High" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "0.000" "False" "101.517" "34" "15" "32" "15" "509" "54.1" "7.85" "104.96" "15" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Mitochondrial protein degradation; Glycine degradation" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)" "19" "0" "0.960" "0.941" "0.971" "0.975" "0.932" "0.952" "0.951" "0.927" "0.932" "3535.8" "3393.3" "3325.9" "3432.1" "3447.0" "3295.1" "3365.8" "3363.8" "3278.7" "3294.5" "" "" "" "" "" "" "" "" "" "" "2839.9" "2448.5" "2641.9" "2299.5" "2384.0" "2472.3" "2356.6" "2456.6" "3278.7" "2679.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3607998631011874723" "False" "High" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "0.000" "False" "101.423" "48" "12" "29" "12" "328" "35.6" "7.39" "119.03" "12" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "0.970" "0.948" "0.943" "0.972" "0.954" "0.941" "0.923" "0.914" "0.956" "2274.0" "2205.5" "2156.9" "2145.0" "2211.3" "2168.5" "2138.9" "2099.0" "2078.7" "2175.1" "" "" "" "" "" "" "" "" "" "" "1826.5" "1591.4" "1713.3" "1437.2" "1529.4" "1627.0" "1497.6" "1532.9" "2078.7" "1768.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4008936127769007747" "False" "High" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "0.000" "False" "101.379" "21" "24" "31" "17" "1243" "140.3" "8.22" "96.72" "24" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "Synthesis of pyrophosphates in the cytosol" "" "1" "6" "1.017" "1.022" "1.025" "1.034" "0.980" "1.004" "1.000" "1.005" "1.017" "1694.2" "1723.7" "1731.4" "1735.8" "1752.4" "1661.1" "1701.0" "1694.7" "1703.3" "1722.6" "" "" "" "" "" "" "" "" "" "" "1360.8" "1243.8" "1375.3" "1163.0" "1211.9" "1246.3" "1190.9" "1237.7" "1703.3" "1400.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1726456948051343577" "False" "High" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "0.000" "False" "101.366" "34" "18" "23" "18" "650" "72.5" "8.05" "88.11" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "0.990" "1.054" "1.119" "1.073" "1.054" "0.978" "1.043" "1.051" "1.097" "842.2" "833.9" "887.6" "942.1" "903.3" "887.8" "823.3" "878.7" "885.2" "923.7" "" "" "" "" "" "" "" "" "" "" "676.5" "601.7" "705.1" "631.2" "624.7" "666.1" "576.4" "641.7" "885.2" "751.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9177231757861531522" "False" "High" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "0.000" "False" "101.151" "48" "18" "33" "17" "340" "38.0" "8.63" "103.31" "18" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "Nuclear receptors meta-pathway; NRF2 pathway" "7" "1" "1.069" "1.000" "1.117" "0.943" "1.023" "1.009" "1.111" "1.009" "1.061" "1837.4" "1963.9" "1838.2" "2053.2" "1732.0" "1880.2" "1854.5" "2041.3" "1853.2" "1949.4" "" "" "" "" "" "" "" "" "" "" "1475.8" "1417.1" "1460.1" "1375.7" "1197.9" "1410.7" "1298.4" "1490.7" "1853.2" "1585.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184402302268645522" "False" "High" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "0.000" "False" "101.071" "21" "21" "33" "21" "1037" "117.3" "6.92" "106.71" "21" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "Mitochondrial protein import" "" "1" "0" "0.992" "1.007" "1.004" "0.985" "0.973" "0.979" "0.968" "0.978" "0.999" "2884.2" "2860.5" "2905.3" "2895.6" "2841.8" "2805.6" "2824.0" "2793.2" "2820.8" "2882.5" "" "" "" "" "" "" "" "" "" "" "2316.6" "2064.1" "2307.7" "1940.0" "1965.4" "2105.0" "1977.2" "2039.9" "2820.8" "2344.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4326632445175340721" "False" "High" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "0.000" "False" "101.014" "35" "9" "56" "8" "391" "45.3" "4.46" "192.00" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "2" "1" "1.003" "1.000" "1.039" "1.037" "1.014" "1.028" "1.016" "1.053" "1.031" "3395.5" "3404.6" "3397.1" "3529.3" "3521.6" "3443.3" "3491.0" "3448.6" "3574.1" "3501.2" "" "" "" "" "" "" "" "" "" "" "2727.2" "2456.7" "2698.4" "2364.6" "2435.6" "2583.5" "2444.2" "2518.5" "3574.1" "2847.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6289921617317730415" "False" "High" "IsMasterProtein" "Q9BWF3" "RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1" "0.000" "False" "100.982" "45" "14" "28" "3" "364" "40.3" "7.08" "100.57" "14" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00098" "5936" "ENSG00000173933" "RBM4" "B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3" "Circadian Clock" "" "1" "11" "1.055" "1.049" "1.013" "1.052" "1.046" "0.996" "1.040" "1.054" "1.028" "2015.3" "2126.5" "2113.1" "2042.2" "2119.1" "2107.2" "2007.9" "2096.8" "2123.8" "2072.4" "" "" "" "" "" "" "" "" "" "" "1618.6" "1534.4" "1678.5" "1368.2" "1465.6" "1581.0" "1405.8" "1531.3" "2123.8" "1685.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3614500297026839647" "False" "High" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "0.000" "False" "100.886" "43" "14" "47" "13" "331" "38.2" "5.38" "147.20" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; RND2 GTPase cycle; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; PAFAH1B1 copy number variation" "9" "0" "1.004" "1.032" "1.007" "0.989" "0.980" "1.018" "0.996" "1.020" "0.992" "5336.1" "5358.4" "5507.1" "5370.9" "5276.6" "5229.4" "5432.7" "5314.8" "5443.9" "5290.8" "" "" "" "" "" "" "" "" "" "" "4285.9" "3866.5" "4374.5" "3598.5" "3649.4" "3923.5" "3803.7" "3881.4" "5443.9" "4302.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630142415015692295" "False" "High" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "0.000" "False" "100.744" "31" "13" "41" "13" "528" "59.4" "4.41" "140.50" "13" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "" "7" "0" "1.013" "0.989" "1.057" "1.064" "1.079" "1.123" "1.083" "1.158" "1.078" "3066.5" "3105.0" "3033.9" "3241.8" "3263.1" "3307.8" "3442.9" "3319.7" "3549.7" "3306.1" "" "" "" "" "" "" "" "" "" "" "2463.0" "2240.5" "2409.9" "2172.0" "2256.8" "2481.8" "2410.5" "2424.4" "3549.7" "2688.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7312941423538826307" "False" "High" "IsMasterProtein" "P31350" "Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1" "0.000" "False" "100.658" "53" "17" "39" "15" "389" "44.8" "5.38" "122.10" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00268" "6241" "ENSG00000171848" "RRM2" "B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7" "Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway" "8" "1" "1.013" "1.023" "1.029" "1.009" "0.934" "1.248" "1.484" "1.366" "1.106" "2057.9" "2083.9" "2105.0" "2117.2" "2077.2" "1921.7" "2569.1" "3053.3" "2811.8" "2275.4" "" "" "" "" "" "" "" "" "" "" "1652.8" "1503.7" "1672.0" "1418.5" "1436.6" "1441.8" "1798.7" "2229.8" "2811.8" "1850.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215357132518723376" "False" "High" "IsMasterProtein" "P30040" "Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4" "0.000" "False" "100.545" "52" "10" "23" "10" "261" "29.0" "7.31" "71.18" "10" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf07749, Pf07912" "10961" "ENSG00000089248" "ERP29" "C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4" "" "" "0" "0" "1.014" "0.971" "1.012" "1.043" "1.007" "1.072" "1.115" "1.085" "1.012" "2267.5" "2298.9" "2202.6" "2293.7" "2364.2" "2282.8" "2431.7" "2528.4" "2460.6" "2295.3" "" "" "" "" "" "" "" "" "" "" "1821.2" "1658.8" "1749.6" "1536.8" "1635.1" "1712.7" "1702.6" "1846.5" "2460.6" "1866.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431694603937659134" "False" "High" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "0.000" "False" "100.451" "70" "9" "65" "5" "152" "17.1" "6.19" "217.33" "9" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "Pyrimidine metabolism" "4" "0" "0.966" "1.045" "0.994" "0.982" "1.004" "0.913" "0.971" "0.937" "0.980" "3300.4" "3187.2" "3447.5" "3280.9" "3241.7" "3314.1" "3014.2" "3203.6" "3092.2" "3235.5" "" "" "" "" "" "" "" "" "" "" "2650.9" "2299.8" "2738.4" "2198.2" "2242.0" "2486.5" "2110.4" "2339.6" "3092.2" "2631.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7309351128836490355" "False" "High" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "0.000" "False" "100.429" "50" "11" "42" "9" "209" "24.0" "7.81" "127.00" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Apoptosis induced DNA fragmentation" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "4" "1" "1.034" "1.087" "1.068" "1.118" "1.142" "1.086" "1.072" "1.097" "1.078" "3771.6" "3900.1" "4100.8" "4028.4" "4218.2" "4308.7" "4097.7" "4041.9" "4135.6" "4065.4" "" "" "" "" "" "" "" "" "" "" "3029.3" "2814.2" "3257.4" "2699.0" "2917.3" "3232.8" "2869.0" "2951.8" "4135.6" "3306.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5442629486260098393" "False" "High" "IsMasterProtein" "Q05397" "Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2" "0.000" "False" "100.353" "22" "21" "39" "20" "1052" "119.2" "6.62" "110.32" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "5747" "ENSG00000169398" "PTK2" "B4E2N6; F5H4S4; hsa:5747; J3QT16; Q05397; Q14291; Q8IYN9; Q9UD85" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Apoptotic cleavage of cellular proteins; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Signal regulatory protein family interactions; DCC mediated attractive signaling; RAF/MAP kinase cascade; VEGFA-VEGFR2 Pathway; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; MET activates PTK2 signaling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "Androgen receptor signaling pathway; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Corticotropin-releasing hormone signaling pathway; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Overview of nanoparticle effects; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Hippo-Merlin signaling dysregulation; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Small cell lung cancer; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; 2q13 copy number variation syndrome; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; ErbB signaling pathway" "51" "0" "1.032" "0.988" "1.068" "1.046" "1.012" "0.998" "1.004" "1.011" "1.012" "1814.6" "1871.8" "1793.6" "1937.4" "1897.7" "1836.1" "1811.3" "1821.9" "1834.5" "1836.1" "" "" "" "" "" "" "" "" "" "" "1457.5" "1350.6" "1424.7" "1298.1" "1312.4" "1377.6" "1268.2" "1330.6" "1834.5" "1493.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5993686438301718268" "False" "High" "IsMasterProtein" "Q96P11" "28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2" "0.000" "False" "100.260" "48" "17" "26" "17" "429" "46.7" "8.62" "86.98" "17" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf21148, Pf21153" "55695" "ENSG00000130305" "NSUN5" "B3KX04; B4DP79; G3V0G9; hsa:55695; Q6ZUI8; Q96HT9; Q96P11; Q9NW70" "" "" "0" "0" "1.063" "1.054" "1.055" "1.098" "1.039" "0.986" "1.049" "0.983" "1.066" "1829.5" "1944.5" "1927.7" "1929.6" "2008.9" "1900.6" "1804.6" "1920.0" "1798.6" "1949.5" "" "" "" "" "" "" "" "" "" "" "1469.4" "1403.1" "1531.2" "1292.8" "1389.3" "1426.0" "1263.5" "1402.2" "1798.6" "1585.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7719784497129908869" "False" "High" "IsMasterProtein" "O60566" "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3" "0.000" "False" "100.241" "22" "22" "28" "22" "1050" "119.5" "5.27" "92.01" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf08311" "701" "ENSG00000156970" "BUB1B" "B2R6U0; B4DL09; B4DLG3; hsa:701; O60501; O60566; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "12" "0" "0.965" "1.011" "1.020" "1.022" "0.960" "1.025" "1.064" "1.092" "1.012" "1752.4" "1690.9" "1771.7" "1787.2" "1790.6" "1682.6" "1796.1" "1864.7" "1913.4" "1772.6" "" "" "" "" "" "" "" "" "" "" "1407.5" "1220.1" "1407.3" "1197.5" "1238.4" "1262.4" "1257.6" "1361.8" "1913.4" "1441.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "29627463948576905" "False" "High" "IsMasterProtein" "Q9NUQ8" "ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2" "0.000" "False" "100.227" "29" "19" "27" "19" "709" "79.7" "6.34" "89.94" "19" "stress response" "" "other molecular function" "Pf00005, Pf12848" "55324" "ENSG00000161204" "ABCF3" "A8K241; hsa:55324; Q86UA2; Q8NAN1; Q96GS8; Q9H7A8; Q9NUQ8" "" "" "0" "0" "0.984" "0.984" "0.967" "1.009" "0.972" "0.971" "1.045" "1.083" "1.027" "2177.6" "2142.3" "2141.7" "2105.0" "2197.3" "2116.4" "2115.1" "2276.3" "2357.8" "2237.0" "" "" "" "" "" "" "" "" "" "" "1749.0" "1545.8" "1701.2" "1410.4" "1519.6" "1587.9" "1480.9" "1662.4" "2357.8" "1819.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8642503759764886067" "False" "High" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0.000" "False" "100.004" "10" "29" "29" "28" "3114" "357.3" "5.10" "84.82" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Polo-like kinase mediated events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Gastric cancer network 1; Ciliopathies" "9" "1" "1.021" "1.030" "1.059" "1.089" "1.023" "0.939" "0.958" "0.993" "0.995" "1681.4" "1717.4" "1732.0" "1781.0" "1831.2" "1720.8" "1578.9" "1610.2" "1669.3" "1672.5" "" "" "" "" "" "" "" "" "" "" "1350.5" "1239.2" "1375.8" "1193.3" "1266.5" "1291.1" "1105.5" "1176.0" "1669.3" "1360.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5513100547130879649" "False" "High" "IsMasterProtein" "P13797" "Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4" "0.000" "False" "99.927" "12" "8" "81" "1" "630" "70.8" "5.60" "245.81" "8" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf13499" "5358" "ENSG00000102024" "PLS3" "A8K579; B1AQ09; B4DGB4; B7Z6M1; hsa:5358; P13797; Q86YI6" "" "" "0" "0" "0.948" "0.956" "0.898" "0.914" "0.916" "0.888" "0.815" "0.862" "0.918" "674.6" "639.4" "645.0" "606.0" "616.8" "617.7" "599.4" "549.6" "581.4" "619.4" "" "" "" "" "" "" "" "" "" "" "541.9" "461.4" "512.4" "406.0" "426.6" "463.5" "419.6" "401.4" "581.4" "503.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3668121595413898342" "False" "High" "IsMasterProtein" "Q96D46" "60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1" "0.000" "False" "99.909" "35" "15" "28" "15" "503" "57.6" "7.14" "83.84" "15" "transport;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04981, Pf21192, Pf21193" "51068" "ENSG00000169251" "NMD3" "D3DNM7; hsa:51068; Q96D46; Q9Y2Z6" "" "" "0" "0" "1.058" "1.000" "1.024" "1.057" "1.091" "1.082" "1.013" "1.066" "1.068" "1676.5" "1774.5" "1676.9" "1716.7" "1771.9" "1828.5" "1814.1" "1698.2" "1787.1" "1790.7" "" "" "" "" "" "" "" "" "" "" "1346.5" "1280.4" "1332.0" "1150.2" "1225.5" "1371.9" "1270.2" "1240.2" "1787.1" "1456.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716088986514922399" "False" "High" "IsMasterProtein" "Q13617" "Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2" "0.000" "False" "99.885" "32" "20" "35" "20" "745" "86.9" "6.92" "98.54" "20" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8453" "ENSG00000108094" "CUL2" "B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Regulation of expression of SLITs and ROBOs" "Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "6" "0" "1.001" "0.991" "0.993" "1.025" "0.982" "0.981" "0.990" "1.005" "1.003" "2444.9" "2448.4" "2423.1" "2427.6" "2506.0" "2400.3" "2397.9" "2419.8" "2456.6" "2452.4" "" "" "" "" "" "" "" "" "" "" "1963.7" "1766.7" "1924.7" "1626.5" "1733.2" "1800.9" "1678.9" "1767.2" "2456.6" "1994.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-15854148761745197" "False" "High" "IsMasterProtein" "Q6IN85" "Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1" "0.000" "False" "99.849" "24" "15" "23" "12" "833" "95.3" "4.94" "74.73" "15" "stress response" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "55671" "ENSG00000100796" "PPP4R3A" "hsa:55671; Q69YK6; Q6IN85; Q86U23; Q86YI7; Q8IVG1; Q9H3F1; Q9H7U8; Q9NV01; Q9NWP1" "" "16p11.2 proximal deletion syndrome" "1" "3" "0.989" "0.932" "0.925" "0.920" "0.936" "0.866" "0.955" "0.912" "0.942" "1875.2" "1855.2" "1748.2" "1733.7" "1725.0" "1754.9" "1623.2" "1791.1" "1711.0" "1766.4" "" "" "" "" "" "" "" "" "" "" "1506.1" "1338.7" "1388.6" "1161.6" "1193.0" "1316.6" "1136.5" "1308.1" "1711.0" "1436.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594801350968766228" "False" "High" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "0.000" "False" "99.847" "36" "13" "26" "13" "396" "45.4" "8.91" "93.83" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "" "2" "0" "0.997" "1.024" "0.882" "0.933" "0.992" "0.868" "0.913" "0.957" "0.932" "2269.7" "2262.7" "2323.4" "2000.8" "2117.7" "2252.7" "1970.1" "2072.5" "2171.1" "2115.7" "" "" "" "" "" "" "" "" "" "" "1823.0" "1632.7" "1845.6" "1340.6" "1464.6" "1690.1" "1379.3" "1513.6" "2171.1" "1720.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5964794776079938030" "False" "High" "IsMasterProtein" "P56537" "Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1" "0.000" "False" "99.711" "60" "9" "20" "9" "245" "26.6" "4.68" "81.38" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01912" "3692" "ENSG00000242372" "EIF6" "B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5" "" "Translation factors; Genetic causes of porto-sinusoidal vascular disease" "2" "0" "0.927" "0.921" "0.970" "1.002" "0.988" "1.029" "0.949" "0.954" "0.998" "1210.1" "1121.3" "1114.6" "1173.5" "1213.1" "1195.6" "1244.7" "1148.2" "1154.7" "1207.5" "" "" "" "" "" "" "" "" "" "" "972.0" "809.1" "885.4" "786.2" "839.0" "897.1" "871.5" "838.5" "1154.7" "982.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "306109377846906281" "False" "High" "IsMasterProtein" "P49247" "Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3" "0.000" "False" "99.639" "48" "12" "31" "12" "311" "33.2" "8.54" "94.19" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf06026" "22934" "ENSG00000153574" "RPIA" "hsa:22934; P49247; Q541P9; Q96BJ6" "Pentose phosphate pathway; RPIA deficiency: failed conversion of R5P to RU5P; RPIA deficiency: failed conversion of RU5P to R5P" "Pentose phosphate metabolism; Metabolic reprogramming in colon cancer; Pentose phosphate pathway in senescent cells" "6" "0" "0.981" "0.956" "0.996" "0.877" "0.894" "0.855" "0.796" "0.842" "0.888" "2315.9" "2272.0" "2214.1" "2307.0" "2031.2" "2070.7" "1980.2" "1842.4" "1950.5" "2056.1" "" "" "" "" "" "" "" "" "" "" "1860.1" "1639.4" "1758.7" "1545.7" "1404.8" "1553.6" "1386.4" "1345.5" "1950.5" "1672.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877503792566385355" "False" "High" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "0.000" "False" "99.443" "48" "11" "25" "11" "258" "29.0" "4.83" "91.40" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "1.062" "1.051" "1.157" "1.063" "1.058" "1.249" "1.071" "1.068" "1.085" "2428.3" "2578.0" "2552.6" "2810.7" "2581.6" "2569.1" "3032.2" "2601.5" "2594.0" "2635.4" "" "" "" "" "" "" "" "" "" "" "1950.4" "1860.2" "2027.6" "1883.2" "1785.4" "1927.5" "2123.0" "1899.9" "2594.0" "2143.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8357658854123366068" "False" "High" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "0.000" "False" "99.420" "28" "11" "22" "6" "521" "57.9" "4.96" "102.50" "11" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "Leptin signaling pathway" "3" "2" "1.035" "1.062" "1.050" "0.979" "0.991" "0.997" "1.109" "1.112" "1.062" "731.6" "757.2" "776.6" "768.2" "716.0" "725.0" "729.5" "811.3" "813.7" "777.2" "" "" "" "" "" "" "" "" "" "" "587.6" "546.4" "616.9" "514.7" "495.2" "544.0" "510.8" "592.5" "813.7" "632.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6341568024441871550" "False" "High" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "0.000" "False" "99.357" "39" "18" "40" "18" "537" "60.1" "5.85" "113.44" "18" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "" "2" "0" "0.984" "1.022" "0.961" "1.006" "0.992" "0.961" "0.959" "0.924" "0.983" "4423.6" "4354.9" "4523.0" "4249.2" "4448.2" "4389.9" "4252.3" "4241.3" "4087.4" "4348.6" "" "" "" "" "" "" "" "" "" "" "3553.0" "3142.4" "3592.8" "2847.0" "3076.4" "3293.7" "2977.2" "3097.5" "4087.4" "3536.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "715968340642640214" "False" "High" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "0.000" "False" "99.292" "41" "21" "29" "21" "602" "68.2" "6.43" "91.87" "21" "signal transduction" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "1.002" "0.990" "1.029" "0.965" "0.900" "0.921" "1.025" "1.012" "0.964" "2331.4" "2336.2" "2308.8" "2399.0" "2248.8" "2099.0" "2147.4" "2390.0" "2360.1" "2248.4" "" "" "" "" "" "" "" "" "" "" "1872.6" "1685.7" "1833.9" "1607.3" "1555.3" "1574.9" "1503.5" "1745.4" "2360.1" "1828.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926750901402698685" "False" "High" "IsMasterProtein" "Q9UKG1" "DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1" "0.000" "False" "99.279" "27" "15" "25" "15" "709" "79.6" "5.41" "81.74" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00640, Pf16746" "26060" "ENSG00000157500" "APPL1" "hsa:26060; Q9P2B9; Q9UKG1" "Caspase activation via Dependence Receptors in the absence of ligand" "Follicle stimulating hormone (FSH) signaling pathway; Chromosomal and microsatellite instability in colorectal cancer" "3" "0" "1.025" "0.997" "1.030" "1.012" "0.999" "0.991" "1.023" "1.034" "1.019" "1689.3" "1730.9" "1684.5" "1740.2" "1709.4" "1686.8" "1674.9" "1727.8" "1746.8" "1722.2" "" "" "" "" "" "" "" "" "" "" "1356.8" "1248.9" "1338.0" "1165.9" "1182.3" "1265.6" "1172.7" "1261.8" "1746.8" "1400.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133999276561542569" "False" "High" "IsMasterProtein" "Q86X55" "Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3" "0.000" "False" "98.983" "28" "15" "27" "15" "608" "65.8" "6.73" "94.07" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06325, Pf11531" "10498" "ENSG00000142453" "CARM1" "A6NN38; hsa:10498; Q86X55" "Estrogen-dependent gene expression; RMTs methylate histone arginines; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression" "Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis" "15" "0" "1.031" "1.027" "0.984" "1.065" "1.020" "0.972" "0.996" "1.007" "1.086" "1532.4" "1580.5" "1573.2" "1508.4" "1632.3" "1562.5" "1490.0" "1525.7" "1543.7" "1663.6" "" "" "" "" "" "" "" "" "" "" "1230.8" "1140.5" "1249.6" "1010.6" "1128.9" "1172.3" "1043.2" "1114.2" "1543.7" "1352.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421674880825804013" "False" "High" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "0.000" "False" "98.906" "43" "12" "24" "12" "240" "26.7" "5.20" "99.67" "12" "" "other membranes" "other molecular function" "Pf21008" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "RHOD GTPase cycle" "" "1" "0" "0.996" "1.005" "1.034" "0.930" "0.964" "0.988" "1.030" "0.973" "0.985" "2707.5" "2695.8" "2720.3" "2799.5" "2518.2" "2610.2" "2674.9" "2789.8" "2635.7" "2666.5" "" "" "" "" "" "" "" "" "" "" "2174.6" "1945.2" "2160.8" "1875.7" "1741.6" "1958.4" "1872.8" "2037.4" "2635.7" "2168.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5232006824815591416" "False" "High" "IsMasterProtein" "P14317" "Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3" "0.000" "False" "98.897" "32" "16" "53" "16" "486" "54.0" "4.81" "196.51" "16" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02218" "3059" "ENSG00000180353" "HCLS1" "B4DQ69; hsa:3059; P14317; Q53Y93; Q6IBK9; Q9UDK0" "" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; TYROBP causal network in microglia" "3" "0" "1.029" "1.136" "1.112" "1.078" "1.117" "1.026" "1.074" "1.129" "1.087" "4044.9" "4160.6" "4596.4" "4497.4" "4361.8" "4519.5" "4151.6" "4343.0" "4565.4" "4396.2" "" "" "" "" "" "" "" "" "" "" "3248.8" "3002.2" "3651.1" "3013.3" "3016.7" "3390.9" "2906.7" "3171.7" "4565.4" "3575.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101173507286650100" "False" "High" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "0.000" "False" "98.885" "47" "11" "26" "11" "315" "37.1" "4.64" "92.34" "11" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13202" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "5" "0" "1.054" "1.046" "1.057" "1.179" "1.093" "1.182" "1.256" "1.179" "1.095" "2337.4" "2462.6" "2444.7" "2471.1" "2756.3" "2554.5" "2763.4" "2936.1" "2756.0" "2559.4" "" "" "" "" "" "" "" "" "" "" "1877.4" "1776.9" "1941.9" "1655.6" "1906.3" "1916.6" "1934.8" "2144.3" "2756.0" "2081.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-775611795353196892" "False" "High" "IsMasterProtein" "Q86XI2" "Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1" "0.000" "False" "98.881" "20" "22" "25" "22" "1143" "130.9" "6.87" "83.20" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12422" "54892" "ENSG00000146918" "NCAPG2" "A4D228; hsa:54892; Q7Z3J9; Q86XI2; Q8WUG8; Q9BRX6; Q9H8S2; Q9H9K6" "Condensation of Prophase Chromosomes" "Mesodermal commitment pathway" "2" "0" "0.965" "1.010" "0.987" "0.993" "0.938" "1.004" "0.986" "1.054" "1.021" "1338.0" "1291.6" "1351.5" "1321.1" "1328.4" "1254.7" "1343.1" "1319.6" "1410.5" "1365.9" "" "" "" "" "" "" "" "" "" "" "1074.7" "932.0" "1073.5" "885.2" "918.7" "941.4" "940.4" "963.7" "1410.5" "1110.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1392727006884078861" "False" "High" "IsMasterProtein" "P51692" "Signal transducer and activator of transcription 5B OS=Homo sapiens OX=9606 GN=STAT5B PE=1 SV=2" "0.000" "False" "98.807" "24" "16" "26" "16" "787" "89.8" "6.05" "93.67" "16" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6777" "ENSG00000173757" "STAT5B" "hsa:6777; P51692; Q8WWS8" "Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; ErbB signaling pathway" "51" "0" "0.980" "0.992" "0.947" "0.934" "0.942" "0.882" "0.936" "0.959" "0.948" "2075.4" "2034.9" "2059.4" "1965.0" "1938.7" "1954.3" "1831.2" "1942.5" "1990.3" "1967.5" "" "" "" "" "" "" "" "" "" "" "1666.9" "1468.3" "1635.8" "1316.5" "1340.8" "1466.2" "1282.1" "1418.6" "1990.3" "1600.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8364348392468163032" "False" "High" "IsMasterProtein" "P04040" "Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3" "0.000" "False" "98.739" "32" "16" "24" "16" "527" "59.7" "7.39" "86.86" "16" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00199, Pf06628" "847" "ENSG00000121691" "CAT" "A8K6C0; B2RCZ9; D3DR07; hsa:847; P04040; Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85" "Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; Arsenic metabolism and reactive oxygen species generation; DNA damage response (only ATM dependent)" "12" "0" "1.034" "1.034" "1.046" "1.049" "1.074" "0.991" "0.950" "1.035" "1.025" "2276.2" "2353.5" "2354.0" "2381.2" "2388.4" "2444.9" "2255.6" "2161.3" "2356.3" "2332.4" "" "" "" "" "" "" "" "" "" "" "1828.3" "1698.2" "1869.8" "1595.4" "1651.9" "1834.4" "1579.2" "1578.4" "2356.3" "1896.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5794288011295636240" "False" "High" "IsMasterProtein" "O60502" "Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2" "0.000" "False" "98.582" "23" "19" "26" "19" "916" "102.8" "4.91" "96.32" "19" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07555" "10724" "ENSG00000198408" "OGA" "B7WPB9; D3DR79; E9PGF9; hsa:10724; O60502; O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0" "" "" "0" "0" "1.002" "0.984" "0.980" "0.985" "0.975" "0.941" "0.929" "0.950" "0.977" "2905.7" "2910.8" "2858.9" "2847.1" "2861.2" "2834.2" "2733.3" "2698.4" "2760.1" "2839.7" "" "" "" "" "" "" "" "" "" "" "2333.9" "2100.3" "2270.9" "1907.6" "1978.8" "2126.5" "1913.7" "1970.6" "2760.1" "2309.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480641512252917896" "False" "High" "IsMasterProtein" "Q9NRF8" "CTP synthase 2 OS=Homo sapiens OX=9606 GN=CTPS2 PE=1 SV=1" "0.000" "False" "98.527" "33" "18" "24" "16" "586" "65.6" "6.90" "86.49" "18" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "56474" "ENSG00000047230" "CTPS2" "B3KWM2; hsa:56474; Q9BRI0; Q9H809; Q9H8K9; Q9NRF8" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "0.970" "1.000" "0.976" "0.963" "0.971" "0.938" "0.951" "0.907" "0.971" "1777.7" "1725.1" "1777.4" "1734.7" "1711.8" "1726.1" "1668.3" "1690.8" "1612.4" "1726.4" "" "" "" "" "" "" "" "" "" "" "1427.9" "1244.8" "1411.9" "1162.3" "1183.9" "1295.1" "1168.1" "1234.8" "1612.4" "1404.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-912573818931081677" "False" "High" "IsMasterProtein" "P48736" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PIK3CG PE=1 SV=3" "0.000" "False" "98.513" "23" "21" "27" "21" "1102" "126.4" "7.50" "90.13" "21" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf19710" "5294" "ENSG00000105851" "PIK3CG" "A4D0Q6; hsa:5294; P48736; Q8IV23; Q9BZC8" "Synthesis of PIPs at the plasma membrane; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; G beta:gamma signalling through PI3Kgamma; Signaling by CSF1 (M-CSF) in myeloid cells" "IL-5 signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; BDNF-TrkB signaling; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; Microglia pathogen phagocytosis pathway; PI3K-Akt signaling pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Prostaglandin signaling; Opioid receptor pathways; Regulation of actin cytoskeleton; EPO receptor signaling; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "40" "0" "0.977" "0.958" "1.011" "0.960" "1.001" "0.854" "0.838" "0.855" "0.961" "2479.3" "2423.1" "2375.0" "2505.7" "2379.1" "2480.9" "2116.7" "2078.0" "2118.8" "2381.9" "" "" "" "" "" "" "" "" "" "" "1991.4" "1748.4" "1886.5" "1678.8" "1645.4" "1861.4" "1482.0" "1517.5" "2118.8" "1937.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5156803787758571728" "False" "High" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "0.000" "False" "98.419" "16" "12" "39" "12" "709" "78.3" "5.25" "132.85" "12" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "1.027" "1.054" "0.993" "1.009" "1.113" "1.089" "1.072" "1.094" "1.078" "4459.8" "4579.3" "4702.0" "4426.6" "4498.9" "4963.4" "4858.5" "4781.2" "4878.3" "4808.5" "" "" "" "" "" "" "" "" "" "" "3582.1" "3304.3" "3734.9" "2965.8" "3111.5" "3723.9" "3401.7" "3491.7" "4878.3" "3910.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3382226448836069029" "False" "High" "IsMasterProtein" "Q69YH5" "Cell division cycle-associated protein 2 OS=Homo sapiens OX=9606 GN=CDCA2 PE=1 SV=2" "0.000" "False" "98.341" "21" "14" "18" "14" "1023" "112.6" "8.40" "64.05" "14" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15276" "157313" "ENSG00000184661" "CDCA2" "hsa:157313; Q3SX74; Q4G0W0; Q5RKN0; Q69YH5; Q69YI4; Q6P464; Q8N7C1" "" "" "0" "0" "0.991" "0.959" "1.000" "0.998" "0.975" "0.877" "0.977" "0.963" "1.030" "996.5" "987.5" "955.5" "996.0" "994.3" "971.1" "874.3" "973.4" "959.4" "1026.5" "" "" "" "" "" "" "" "" "" "" "800.3" "712.5" "759.0" "667.3" "687.6" "728.6" "612.1" "710.9" "959.4" "834.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "575665869234459474" "False" "High" "IsMasterProtein" "P42331" "Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2" "0.000" "False" "98.267" "30" "18" "22" "18" "645" "73.4" "6.37" "77.85" "18" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane" "enzyme regulator activity" "Pf00169, Pf00620" "9938" "ENSG00000163219" "ARHGAP25" "A8K2Y1; B7Z498; E9PFQ7; G5E9G2; hsa:9938; P42331; Q8IXQ2" "RAC1 GTPase cycle" "" "1" "0" "0.997" "0.968" "0.974" "0.990" "0.992" "0.954" "0.979" "0.982" "0.992" "2361.7" "2355.7" "2287.0" "2299.4" "2338.3" "2342.1" "2252.8" "2312.3" "2319.0" "2342.1" "" "" "" "" "" "" "" "" "" "" "1896.9" "1699.8" "1816.6" "1540.6" "1617.2" "1757.3" "1577.3" "1688.6" "2319.0" "1904.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701772359172858038" "False" "High" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "0.000" "False" "98.186" "15" "19" "22" "19" "1475" "153.8" "8.73" "81.93" "19" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA replication proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "TGF-beta signaling pathway" "29" "0" "1.019" "1.046" "1.025" "1.099" "1.083" "1.052" "1.184" "1.145" "1.093" "2351.9" "2396.5" "2461.1" "2410.3" "2585.7" "2547.5" "2474.4" "2783.8" "2693.3" "2570.7" "" "" "" "" "" "" "" "" "" "" "1889.0" "1729.3" "1954.9" "1614.9" "1788.3" "1911.3" "1732.4" "2033.0" "2693.3" "2090.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8024352083789976777" "False" "High" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "0.000" "False" "98.150" "14" "19" "25" "18" "1341" "151.8" "6.43" "88.67" "19" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "" "2" "1" "0.954" "0.985" "1.038" "1.020" "1.157" "1.144" "1.087" "1.164" "1.043" "2046.8" "1951.9" "2015.6" "2124.0" "2088.1" "2368.0" "2341.7" "2224.7" "2383.3" "2134.4" "" "" "" "" "" "" "" "" "" "" "1644.0" "1408.5" "1601.1" "1423.1" "1444.2" "1776.7" "1639.5" "1624.7" "2383.3" "1735.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3099345167640791747" "False" "High" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "0.000" "False" "98.144" "36" "10" "24" "10" "357" "38.3" "7.97" "95.48" "10" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "Disorders of fructose metabolism; Polyol pathway" "4" "0" "0.969" "0.959" "0.940" "0.976" "1.004" "0.983" "0.952" "0.961" "0.966" "1889.5" "1830.3" "1812.6" "1776.1" "1844.1" "1897.6" "1857.8" "1798.4" "1816.0" "1824.8" "" "" "" "" "" "" "" "" "" "" "1517.6" "1320.7" "1439.8" "1190.0" "1275.4" "1423.7" "1300.7" "1313.4" "1816.0" "1484.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625580668015925346" "False" "High" "IsMasterProtein" "Q9HCK8" "Chromodomain-helicase-DNA-binding protein 8 OS=Homo sapiens OX=9606 GN=CHD8 PE=1 SV=5" "0.000" "False" "97.940" "11" "22" "24" "15" "2581" "290.3" "6.47" "80.74" "22" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "57680" "ENSG00000100888" "CHD8" "hsa:57680; Q4G0D8; Q68DQ0; Q6DKH9; Q6P440; Q6ZNL7; Q8N3Z9; Q8NCY4; Q8TBR9; Q96F26; Q9HCK8" "Deactivation of the beta-catenin transactivating complex" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "5" "1" "1.049" "0.980" "1.023" "0.991" "0.931" "0.934" "1.040" "1.014" "1.037" "1181.1" "1239.0" "1157.2" "1207.9" "1170.8" "1099.8" "1103.1" "1228.6" "1198.0" "1224.2" "" "" "" "" "" "" "" "" "" "" "948.6" "894.0" "919.2" "809.3" "809.8" "825.1" "772.3" "897.2" "1198.0" "995.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5365621191326057651" "False" "High" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "0.000" "False" "97.914" "57" "11" "48" "11" "239" "26.5" "7.81" "138.50" "11" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "1.012" "1.016" "0.983" "1.023" "0.970" "0.981" "0.956" "1.038" "0.967" "3576.2" "3618.7" "3634.9" "3514.0" "3658.1" "3467.5" "3508.4" "3420.0" "3711.2" "3457.4" "" "" "" "" "" "" "" "" "" "" "2872.3" "2611.1" "2887.3" "2354.4" "2530.0" "2601.6" "2456.4" "2497.7" "3711.2" "2811.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7367615421387894087" "False" "High" "IsMasterProtein" "Q9Y5X3" "Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1" "0.000" "False" "97.900" "36" "13" "31" "12" "404" "46.8" "6.76" "109.53" "13" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "27131" "ENSG00000089006" "SNX5" "B7ZKN3; D3DW26; hsa:27131; Q52LC4; Q7KZN0; Q9BWP0; Q9Y5X3" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "1.011" "1.009" "1.001" "0.982" "0.952" "0.905" "0.940" "0.967" "0.960" "3818.8" "3862.2" "3853.6" "3823.8" "3749.0" "3637.1" "3457.7" "3591.4" "3692.2" "3665.5" "" "" "" "" "" "" "" "" "" "" "3067.2" "2786.9" "3061.1" "2562.0" "2592.9" "2728.8" "2420.9" "2622.8" "3692.2" "2980.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1757040485264551221" "False" "High" "IsMasterProtein" "Q9Y6A5" "Transforming acidic coiled-coil-containing protein 3 OS=Homo sapiens OX=9606 GN=TACC3 PE=1 SV=1" "0.000" "False" "97.880" "24" "17" "26" "17" "838" "90.3" "5.05" "85.54" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf05010" "10460" "ENSG00000013810" "TACC3" "hsa:10460; Q2NKK4; Q3KQS5; Q9UMQ1; Q9Y6A5" "Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus" "4p16.3 copy number variation" "3" "0" "0.997" "0.984" "0.999" "0.987" "1.012" "1.075" "1.020" "1.109" "1.028" "1375.2" "1370.6" "1352.9" "1374.4" "1356.8" "1391.1" "1478.0" "1402.4" "1525.6" "1413.9" "" "" "" "" "" "" "" "" "" "" "1104.6" "989.0" "1074.6" "920.9" "938.4" "1043.7" "1034.8" "1024.1" "1525.6" "1149.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2843591473366045892" "False" "High" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "0.000" "False" "97.841" "52" "13" "32" "4" "330" "37.5" "6.33" "110.81" "13" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins; DARPP-32 events" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system" "15" "9" "0.969" "0.978" "1.030" "1.005" "1.015" "1.032" "0.973" "0.959" "1.029" "2492.6" "2415.6" "2438.4" "2567.3" "2504.0" "2530.6" "2573.6" "2425.5" "2391.4" "2565.7" "" "" "" "" "" "" "" "" "" "" "2002.1" "1743.0" "1936.9" "1720.1" "1731.8" "1898.6" "1801.9" "1771.3" "2391.4" "2086.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691661012823891973" "False" "High" "IsMasterProtein" "P54278" "Mismatch repair endonuclease PMS2 OS=Homo sapiens OX=9606 GN=PMS2 PE=1 SV=2" "0.000" "False" "97.776" "26" "18" "22" "16" "862" "95.7" "6.86" "74.49" "18" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01119, Pf08676, Pf13589" "5395" "ENSG00000122512" "PMS2" "B2R610; hsa:5395; P54278; Q52LH6; Q5FBW9; Q5FBX1; Q5FBX2; Q75MR2" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "Male infertility; DNA repair pathways, full network; DNA mismatch repair" "8" "2" "0.986" "0.957" "1.005" "0.955" "0.961" "0.877" "0.928" "0.924" "0.922" "1372.4" "1353.9" "1313.9" "1379.1" "1310.5" "1318.6" "1204.1" "1273.2" "1268.3" "1265.8" "" "" "" "" "" "" "" "" "" "" "1102.3" "976.9" "1043.7" "924.0" "906.3" "989.3" "843.0" "929.8" "1268.3" "1029.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-91982353768306611" "False" "High" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "0.000" "False" "97.701" "67" "11" "39" "11" "218" "24.6" "6.68" "116.54" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "Mesodermal commitment pathway" "4" "0" "0.933" "0.948" "0.940" "0.978" "0.927" "0.960" "0.940" "0.897" "0.911" "2971.3" "2771.7" "2817.3" "2793.6" "2907.2" "2755.1" "2851.6" "2793.3" "2664.7" "2708.2" "" "" "" "" "" "" "" "" "" "" "2386.5" "2000.0" "2237.9" "1871.7" "2010.6" "2067.1" "1996.6" "2039.9" "2664.7" "2202.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4520162396586865811" "False" "High" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "0.000" "False" "97.692" "72" "10" "21" "7" "216" "23.5" "8.41" "80.79" "10" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "10" "3" "0.948" "1.016" "0.994" "1.040" "1.040" "1.010" "0.975" "0.957" "1.008" "1385.0" "1313.4" "1407.3" "1377.3" "1439.8" "1441.1" "1399.0" "1350.9" "1325.5" "1396.3" "" "" "" "" "" "" "" "" "" "" "1112.4" "947.7" "1117.9" "922.8" "995.8" "1081.2" "979.5" "986.5" "1325.5" "1135.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5953183427719841951" "False" "High" "IsMasterProtein" "P18615" "Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3" "0.000" "False" "97.625" "36" "10" "17" "10" "380" "43.2" "9.33" "76.09" "10" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7936" "ENSG00000204356; ENSG00000206268; ENSG00000206357; ENSG00000229363; ENSG00000231044; ENSG00000233801" "NELFE" "A2BE08; B4DUN1; B4DYX9; hsa:7936; P18615; Q5JP74; Q5JP75; Q96F56; Q9NPK2" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "16" "0" "1.039" "1.027" "1.059" "1.006" "0.996" "1.007" "1.028" "0.999" "1.028" "1454.7" "1511.7" "1494.7" "1540.6" "1463.9" "1448.7" "1464.7" "1496.1" "1453.3" "1495.3" "" "" "" "" "" "" "" "" "" "" "1168.4" "1090.8" "1187.3" "1032.2" "1012.5" "1087.0" "1025.5" "1092.6" "1453.3" "1216.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133937274084103067" "False" "High" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "0.000" "False" "97.587" "46" "11" "25" "11" "263" "28.5" "6.92" "93.88" "11" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Asymmetric localization of PCP proteins; Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.964" "0.979" "0.911" "1.006" "1.005" "0.936" "0.982" "0.964" "0.984" "2363.9" "2278.1" "2313.5" "2152.6" "2377.8" "2375.5" "2212.5" "2320.8" "2277.8" "2326.3" "" "" "" "" "" "" "" "" "" "" "1898.6" "1643.8" "1837.7" "1442.2" "1644.5" "1782.3" "1549.1" "1694.9" "2277.8" "1891.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769761607326504072" "False" "High" "IsMasterProtein" "Q9Y3P9" "Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3" "0.000" "False" "97.463" "15" "16" "26" "16" "1069" "121.7" "5.25" "97.22" "16" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00566, Pf00640, Pf12473" "23637" "ENSG00000011454" "RABGAP1" "B9A6L2; hsa:23637; Q05CW2; Q6ZMY1; Q9HA28; Q9P0E2; Q9UG67; Q9Y3P9" "TBC/RABGAPs" "" "1" "0" "1.032" "0.989" "1.018" "1.013" "0.999" "0.961" "0.984" "1.026" "1.005" "1917.2" "1978.7" "1896.3" "1952.1" "1942.4" "1915.9" "1841.7" "1886.9" "1966.6" "1927.3" "" "" "" "" "" "" "" "" "" "" "1539.9" "1427.8" "1506.3" "1307.9" "1343.4" "1437.5" "1289.5" "1378.0" "1966.6" "1567.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117262061430317364" "False" "High" "IsMasterProtein" "Q96T88" "E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1" "0.000" "False" "97.249" "28" "17" "25" "16" "793" "89.8" "7.56" "93.34" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "29128" "ENSG00000276043" "UHRF1" "A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7" "Chromatin modifications during the maternal to zygotic transition (MZT); DNA methylation" "Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma" "4" "1" "0.961" "1.023" "1.088" "1.020" "1.056" "1.441" "1.341" "1.258" "1.105" "1838.4" "1767.6" "1880.0" "1999.5" "1874.5" "1940.8" "2649.0" "2464.6" "2312.0" "2032.1" "" "" "" "" "" "" "" "" "" "" "1476.6" "1275.5" "1493.3" "1339.7" "1296.4" "1456.1" "1854.7" "1799.9" "2312.0" "1652.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7656229856008546485" "False" "High" "IsMasterProtein" "O95453" "Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1" "0.000" "False" "97.220" "29" "17" "30" "17" "639" "73.4" "6.20" "98.89" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857, Pf08675" "5073" "ENSG00000140694; ENSG00000274829" "PARN" "B2RCB3; B4DDG8; B4DSB0; B4DWR4; B4E1H6; hsa:5073; O95453" "Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "Lung fibrosis" "4" "0" "1.022" "0.978" "1.034" "1.011" "0.979" "0.998" "1.034" "1.025" "1.021" "2774.6" "2835.7" "2714.7" "2869.2" "2806.3" "2715.6" "2770.4" "2869.7" "2845.3" "2832.6" "" "" "" "" "" "" "" "" "" "" "2228.6" "2046.2" "2156.4" "1922.3" "1940.9" "2037.4" "1939.7" "2095.7" "2845.3" "2303.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4576818443980197018" "False" "High" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "0.000" "False" "97.199" "36" "14" "26" "14" "529" "57.8" "5.40" "95.50" "14" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "" "8" "0" "1.051" "1.030" "1.181" "1.080" "0.944" "1.046" "0.989" "0.929" "0.994" "1760.3" "1850.2" "1813.6" "2079.1" "1901.7" "1662.2" "1840.8" "1741.0" "1634.5" "1749.4" "" "" "" "" "" "" "" "" "" "" "1413.9" "1335.1" "1440.6" "1393.0" "1315.3" "1247.2" "1288.8" "1271.4" "1634.5" "1422.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5632561991288096733" "False" "High" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "0.000" "False" "97.184" "19" "21" "32" "21" "1135" "128.1" "7.83" "97.95" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "1.019" "1.071" "1.063" "1.053" "1.036" "1.013" "1.055" "1.026" "1.054" "2299.0" "2342.0" "2461.7" "2444.6" "2420.1" "2382.6" "2329.5" "2424.7" "2359.1" "2423.2" "" "" "" "" "" "" "" "" "" "" "1846.5" "1689.9" "1955.4" "1637.9" "1673.8" "1787.6" "1631.0" "1770.7" "2359.1" "1970.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7286073100971465543" "False" "High" "IsMasterProtein" "O95466" "Formin-like protein 1 OS=Homo sapiens OX=9606 GN=FMNL1 PE=1 SV=3" "0.000" "False" "97.172" "18" "19" "27" "19" "1100" "121.8" "5.72" "82.54" "19" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "752" "ENSG00000184922" "FMNL1" "D2DGW2; hsa:752; O95466; Q6DKG5; Q6IBP3; Q86UH1; Q8N671; Q8TDH1; Q96H10" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate Formins" "" "3" "0" "1.021" "0.990" "1.030" "1.020" "0.985" "0.941" "1.007" "1.038" "0.996" "1688.5" "1723.2" "1671.2" "1739.4" "1721.7" "1662.5" "1589.0" "1700.0" "1752.0" "1682.1" "" "" "" "" "" "" "" "" "" "" "1356.2" "1243.4" "1327.5" "1165.4" "1190.7" "1247.3" "1112.5" "1241.5" "1752.0" "1368.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3635452200201599036" "False" "High" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "0.000" "False" "97.149" "46" "13" "33" "13" "312" "34.3" "8.43" "106.87" "13" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Ciliary landscape" "3" "0" "1.009" "1.005" "1.071" "1.018" "1.011" "1.085" "1.012" "1.039" "1.010" "1879.3" "1895.5" "1888.3" "2012.5" "1912.1" "1899.9" "2038.3" "1901.3" "1952.0" "1898.6" "" "" "" "" "" "" "" "" "" "" "1509.4" "1367.7" "1499.9" "1348.4" "1322.5" "1425.5" "1427.1" "1388.5" "1952.0" "1544.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741204735065001472" "False" "High" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "0.000" "False" "97.006" "32" "15" "41" "14" "523" "58.7" "6.67" "131.16" "15" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "0" "0.983" "0.989" "0.965" "0.977" "0.936" "0.946" "0.985" "0.975" "0.966" "3033.6" "2980.7" "3001.3" "2928.0" "2962.9" "2838.6" "2870.8" "2987.6" "2959.0" "2930.0" "" "" "" "" "" "" "" "" "" "" "2436.5" "2150.8" "2384.1" "1961.7" "2049.2" "2129.8" "2010.0" "2181.8" "2959.0" "2382.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256235105362563928" "False" "High" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "0.000" "False" "96.977" "52" "13" "204" "12" "165" "18.0" "7.81" "541.38" "13" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "Prolactin signaling pathway" "16" "1" "1.024" "1.021" "1.043" "1.058" "1.057" "1.054" "1.019" "1.038" "1.051" "16360.2" "16747.8" "16705.5" "17062.6" "17302.1" "17292.1" "17243.7" "16671.3" "16981.8" "17201.9" "" "" "" "" "" "" "" "" "" "" "13140.3" "12084.8" "13269.7" "11432.0" "11966.3" "12973.9" "12073.1" "12175.1" "16981.8" "13989.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849479475208291816" "False" "High" "IsMasterProtein" "Q9H8Y5" "tRNA endonuclease ANKZF1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1" "0.000" "False" "96.886" "29" "19" "24" "19" "726" "80.9" "8.41" "83.61" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other cell component" "other molecular function" "Pf00023, Pf18716, Pf18826" "55139" "ENSG00000163516" "ANKZF1" "hsa:55139; Q9H8Y5; Q9NVZ4" "" "" "0" "0" "0.995" "0.971" "1.075" "1.041" "1.016" "0.918" "0.938" "0.967" "0.964" "1370.8" "1363.3" "1331.5" "1473.3" "1427.6" "1392.3" "1258.6" "1285.2" "1325.1" "1321.3" "" "" "" "" "" "" "" "" "" "" "1101.0" "983.7" "1057.6" "987.1" "987.3" "1044.6" "881.2" "938.6" "1325.1" "1074.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-92542688516821267" "False" "High" "IsMasterProtein" "Q14699" "Raftlin OS=Homo sapiens OX=9606 GN=RFTN1 PE=1 SV=4" "0.000" "False" "96.774" "35" "18" "27" "18" "578" "63.1" "5.67" "99.46" "18" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf15250" "23180" "ENSG00000131378" "RFTN1" "hsa:23180; Q0D2G0; Q14699; Q496Y2; Q4QQI7; Q5JB48; Q7Z7P2" "" "" "0" "0" "0.930" "0.877" "0.901" "0.901" "0.971" "1.040" "0.929" "0.960" "0.943" "1821.2" "1693.0" "1596.6" "1641.0" "1640.2" "1769.2" "1894.9" "1692.3" "1747.7" "1717.6" "" "" "" "" "" "" "" "" "" "" "1462.8" "1221.7" "1268.2" "1099.5" "1134.4" "1327.4" "1326.7" "1235.9" "1747.7" "1396.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040349963704556613" "False" "High" "IsMasterProtein" "P30154" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3" "0.000" "False" "96.697" "31" "16" "32" "10" "601" "66.2" "4.94" "102.70" "16" "other biological processes" "other membranes;other cell component" "enzyme regulator activity" "Pf02985, Pf13646" "5519" "ENSG00000137713" "PPP2R1B" "A8MY67; B0YJ69; B4DGQ6; B4DK91; B4DWW5; F8W8G1; hsa:5519; O75620; P30154; Q8NHV8" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DARPP-32 events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "40" "0" "1.021" "1.013" "1.087" "1.020" "0.937" "1.055" "1.055" "1.073" "0.989" "991.8" "1012.7" "1004.7" "1078.1" "1012.1" "929.7" "1046.4" "1046.0" "1064.1" "980.4" "" "" "" "" "" "" "" "" "" "" "796.6" "730.7" "798.0" "722.3" "699.9" "697.5" "732.6" "763.9" "1064.1" "797.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1264593624988505849" "False" "High" "IsMasterProtein" "Q14694" "Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2" "0.000" "False" "96.372" "22" "14" "20" "14" "798" "87.1" "5.31" "80.13" "14" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf07145" "9100" "ENSG00000103194" "USP10" "B2RDJ8; B4DS84; hsa:9100; Q14694; Q9BWG7; Q9NSL7" "Ub-specific processing proteases; Termination of translesion DNA synthesis" "VEGFA-VEGFR2 signaling" "3" "0" "0.965" "1.055" "1.023" "0.994" "1.024" "0.982" "1.034" "1.008" "0.977" "1812.8" "1749.7" "1913.1" "1854.0" "1802.0" "1856.2" "1779.6" "1874.8" "1826.5" "1771.7" "" "" "" "" "" "" "" "" "" "" "1456.0" "1262.5" "1519.6" "1242.2" "1246.3" "1392.7" "1246.0" "1369.2" "1826.5" "1440.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4087674429968217888" "False" "High" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "0.000" "False" "96.299" "23" "22" "34" "7" "937" "104.5" "5.38" "105.45" "22" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; Potential therapeutics for SARS; Recycling pathway of L1; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "20" "0" "1.067" "1.062" "1.058" "1.111" "1.113" "1.036" "1.017" "1.086" "1.170" "446.1" "476.1" "473.9" "471.9" "495.5" "496.6" "462.3" "453.5" "484.5" "521.9" "" "" "" "" "" "" "" "" "" "" "358.3" "343.5" "376.4" "316.2" "342.7" "372.6" "323.7" "331.2" "484.5" "424.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6175620915795625691" "False" "High" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "0.000" "False" "96.184" "41" "10" "37" "9" "305" "30.8" "9.29" "123.82" "10" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "1.004" "1.007" "1.068" "1.011" "1.005" "0.999" "0.991" "1.051" "1.010" "2050.1" "2058.8" "2064.3" "2189.2" "2072.7" "2059.9" "2048.9" "2031.7" "2154.7" "2071.6" "" "" "" "" "" "" "" "" "" "" "1646.6" "1485.5" "1639.7" "1466.7" "1433.5" "1545.5" "1434.5" "1483.7" "2154.7" "1684.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222820814571899525" "False" "High" "IsMasterProtein" "Q9UJ70" "N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4" "0.000" "False" "96.175" "43" "11" "25" "11" "344" "37.4" "6.24" "89.15" "11" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01869" "55577" "ENSG00000124357" "NAGK" "B4DLZ5; hsa:55577; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37; Q9UJ70" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "1.046" "1.027" "1.065" "1.042" "1.023" "1.053" "1.060" "1.013" "1.029" "2090.9" "2187.4" "2147.0" "2227.8" "2179.4" "2139.3" "2201.7" "2217.2" "2117.8" "2151.7" "" "" "" "" "" "" "" "" "" "" "1679.4" "1578.4" "1705.4" "1492.7" "1507.3" "1605.1" "1541.5" "1619.2" "2117.8" "1749.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6750207652327358618" "False" "High" "IsMasterProtein" "O43719" "17S U2 SnRNP complex component HTATSF1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1" "0.000" "False" "96.149" "30" "24" "28" "24" "755" "85.8" "4.40" "85.67" "24" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "27336" "ENSG00000102241" "HTATSF1" "D3DWG9; hsa:27336; O43719; Q59G06; Q99730" "mRNA Splicing - Major Pathway" "" "1" "0" "0.961" "0.968" "0.913" "0.866" "0.914" "0.993" "1.076" "1.032" "0.972" "2042.8" "1963.8" "1977.9" "1864.2" "1769.3" "1867.5" "2027.9" "2197.3" "2107.7" "1984.8" "" "" "" "" "" "" "" "" "" "" "1640.8" "1417.0" "1571.1" "1249.0" "1223.6" "1401.2" "1419.8" "1604.7" "2107.7" "1614.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625848183831329232" "False" "High" "IsMasterProtein" "Q6VMQ6" "Activating transcription factor 7-interacting protein 1 OS=Homo sapiens OX=9606 GN=ATF7IP PE=1 SV=3" "0.000" "False" "96.122" "16" "14" "20" "14" "1270" "136.3" "4.70" "81.52" "14" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf16788, Pf16794" "55729" "ENSG00000171681" "ATF7IP" "F5GX74; G3V1U0; hsa:55729; Q4G0T9; Q6P3T3; Q6VMQ6; Q86XW5; Q9NVJ9; Q9NWC2; Q9Y4X8" "PKMTs methylate histone lysines" "" "1" "0" "0.968" "0.982" "0.928" "0.931" "0.959" "0.884" "0.877" "0.899" "0.994" "995.2" "963.6" "977.6" "923.8" "927.0" "954.0" "880.0" "873.1" "894.7" "989.1" "" "" "" "" "" "" "" "" "" "" "799.3" "695.3" "776.5" "618.9" "641.1" "715.8" "616.2" "637.6" "894.7" "804.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428809261446700766" "False" "High" "IsMasterProtein" "Q9UNN5" "FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2" "0.000" "False" "95.899" "24" "13" "20" "13" "650" "73.9" "4.88" "80.99" "13" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "11124" "ENSG00000185104" "FAF1" "hsa:11124; Q549F0; Q9UF34; Q9UNN5; Q9UNT3; Q9Y2Z3" "" "Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; VEGFA-VEGFR2 signaling" "3" "0" "1.012" "1.006" "0.995" "0.930" "0.982" "0.950" "0.981" "0.972" "0.987" "1965.0" "1989.4" "1976.7" "1956.1" "1827.7" "1929.9" "1866.2" "1926.9" "1910.1" "1939.8" "" "" "" "" "" "" "" "" "" "" "1578.3" "1435.5" "1570.2" "1310.6" "1264.1" "1448.0" "1306.6" "1407.2" "1910.1" "1577.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6641856841102683489" "False" "High" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "0.000" "False" "95.837" "46" "10" "55" "10" "216" "24.4" "7.49" "182.57" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Transcriptional regulation by small RNAs; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "11" "0" "0.975" "1.030" "0.913" "0.894" "0.968" "0.790" "0.838" "0.904" "0.908" "5225.7" "5093.9" "5382.3" "4773.5" "4670.3" "5058.3" "4128.8" "4380.7" "4722.4" "4742.3" "" "" "" "" "" "" "" "" "" "" "4197.2" "3675.6" "4275.3" "3198.2" "3230.0" "3795.1" "2890.8" "3199.2" "4722.4" "3856.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2550625188107110862" "False" "High" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "0.000" "False" "95.830" "49" "15" "33" "14" "325" "36.6" "6.79" "102.34" "15" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Glutathione conjugation; Formation of xylulose-5-phosphate" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "4" "1" "0.962" "0.943" "0.929" "0.965" "0.984" "0.913" "0.902" "0.912" "0.966" "2842.9" "2736.0" "2682.1" "2641.7" "2743.0" "2798.4" "2595.4" "2564.4" "2592.4" "2745.9" "" "" "" "" "" "" "" "" "" "" "2283.4" "1974.2" "2130.5" "1770.0" "1897.1" "2099.6" "1817.2" "1872.8" "2592.4" "2233.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7547854547274614235" "False" "High" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "0.000" "False" "95.794" "21" "16" "21" "16" "1059" "112.1" "7.30" "72.66" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "1.014" "0.979" "1.068" "1.024" "0.985" "1.006" "1.066" "1.033" "1.025" "1016.1" "1029.8" "994.4" "1085.3" "1041.0" "1000.6" "1021.8" "1082.8" "1049.5" "1041.3" "" "" "" "" "" "" "" "" "" "" "816.1" "743.1" "789.9" "727.2" "719.9" "750.7" "715.4" "790.8" "1049.5" "846.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-34001002036977343" "False" "High" "IsMasterProtein" "O76003" "Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2" "0.000" "False" "95.783" "38" "11" "30" "11" "335" "37.4" "5.39" "109.49" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00085, Pf00462" "10539" "ENSG00000108010" "GLRX3" "B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1" "Iron uptake and transport" "" "1" "0" "1.020" "0.967" "0.972" "0.958" "0.986" "0.971" "0.990" "0.929" "0.973" "3217.9" "3281.3" "3112.6" "3128.0" "3082.4" "3172.5" "3123.3" "3184.5" "2988.4" "3129.6" "" "" "" "" "" "" "" "" "" "" "2584.6" "2367.7" "2472.5" "2095.8" "2131.8" "2380.3" "2186.8" "2325.6" "2988.4" "2545.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318153562653389017" "False" "High" "IsMasterProtein" "O43837" "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" "0.000" "False" "95.714" "54" "17" "38" "17" "385" "42.2" "8.46" "123.70" "17" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3420" "ENSG00000101365" "IDH3B" "B2RDR1; D3DVX2; D3DVX3; hsa:3420; O43837; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99" "Citric acid cycle (TCA cycle)" "TCA cycle (aka Krebs or citric acid cycle)" "2" "0" "1.072" "1.074" "1.018" "0.995" "1.012" "0.902" "1.043" "1.038" "1.035" "2677.2" "2871.2" "2876.0" "2725.5" "2663.4" "2708.6" "2415.2" "2792.0" "2777.8" "2770.7" "" "" "" "" "" "" "" "" "" "" "2150.3" "2071.7" "2284.5" "1826.1" "1842.0" "2032.2" "1691.0" "2039.0" "2777.8" "2253.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5004824679755995217" "False" "High" "IsMasterProtein" "Q13867" "Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1" "0.000" "False" "95.682" "31" "12" "45" "12" "455" "52.5" "6.27" "150.26" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03051" "642" "ENSG00000108578" "BLMH" "B2R796; hsa:642; Q13867; Q53F86; Q9UER9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.976" "0.959" "0.978" "0.988" "0.955" "0.976" "0.950" "0.929" "0.955" "3925.0" "3830.3" "3764.3" "3840.4" "3879.8" "3746.5" "3831.1" "3729.1" "3647.9" "3749.5" "" "" "" "" "" "" "" "" "" "" "3152.5" "2763.9" "2990.1" "2573.1" "2683.3" "2810.9" "2682.3" "2723.3" "3647.9" "3049.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666399162137355267" "False" "High" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "0.000" "False" "95.675" "62" "16" "38" "16" "255" "27.8" "8.10" "129.25" "16" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "Respiratory electron transport; Protein methylation" "" "2" "0" "0.969" "0.971" "0.992" "0.947" "0.894" "0.939" "0.932" "0.948" "0.954" "3502.4" "3392.2" "3400.9" "3473.8" "3317.2" "3129.9" "3289.2" "3263.5" "3321.0" "3339.6" "" "" "" "" "" "" "" "" "" "" "2813.1" "2447.7" "2701.4" "2327.4" "2294.2" "2348.3" "2302.9" "2383.4" "3321.0" "2715.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1166927996766443346" "False" "High" "IsMasterProtein" "P28482" "Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3" "0.000" "False" "95.659" "58" "17" "29" "12" "360" "41.4" "6.98" "94.20" "17" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "5594" "ENSG00000100030" "MAPK1" "A8CZ64; hsa:5594; P28482" "Recycling pathway of L1; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants" "IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; LTF danger signal response pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway" "208" "5" "1.014" "1.023" "1.046" "1.026" "1.020" "1.007" "1.006" "1.007" "1.008" "3176.7" "3220.2" "3250.9" "3324.0" "3260.7" "3239.5" "3198.9" "3194.9" "3199.7" "3203.1" "" "" "" "" "" "" "" "" "" "" "2551.5" "2323.6" "2582.3" "2227.1" "2255.1" "2430.5" "2239.7" "2333.2" "3199.7" "2604.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7326537803977903766" "False" "High" "IsMasterProtein" "P02786" "Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2" "0.000" "False" "95.500" "27" "18" "22" "18" "760" "84.8" "6.61" "84.85" "18" "stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf02225, Pf04253, Pf04389" "7037" "ENSG00000072274" "TFRC" "D3DXB0; hsa:7037; P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21" "Cargo recognition for clathrin-mediated endocytosis; RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; RND1 GTPase cycle; Transferrin endocytosis and recycling; RHOH GTPase cycle" "Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome; Iron metabolism disorders" "21" "0" "0.957" "0.970" "0.884" "0.979" "0.942" "1.016" "0.947" "0.964" "0.993" "2122.1" "2031.6" "2057.4" "1875.9" "2077.5" "2000.0" "2155.4" "2009.0" "2046.2" "2107.0" "" "" "" "" "" "" "" "" "" "" "1704.5" "1465.9" "1634.3" "1256.9" "1436.8" "1500.5" "1509.1" "1467.2" "2046.2" "1713.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585817169106109779" "False" "High" "IsMasterProtein" "Q9P2D1" "Chromodomain-helicase-DNA-binding protein 7 OS=Homo sapiens OX=9606 GN=CHD7 PE=1 SV=3" "0.000" "False" "95.403" "8" "25" "32" "18" "2997" "335.7" "6.34" "86.80" "25" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "55636" "ENSG00000171316" "CHD7" "D0VBA5; E9PNZ2; hsa:55636; Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; Q9P2D1" "" "Kallmann syndrome" "1" "3" "1.016" "0.926" "1.009" "0.972" "0.960" "0.909" "0.975" "0.954" "0.951" "1617.0" "1642.1" "1497.4" "1630.9" "1571.3" "1552.4" "1469.3" "1576.4" "1542.1" "1537.5" "" "" "" "" "" "" "" "" "" "" "1298.7" "1184.9" "1189.4" "1092.7" "1086.7" "1164.7" "1028.7" "1151.2" "1542.1" "1250.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7061207721996529093" "False" "High" "IsMasterProtein" "P08758" "Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2" "0.000" "False" "95.385" "52" "15" "29" "15" "320" "35.9" "5.05" "90.45" "15" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "308" "ENSG00000164111" "ANXA5" "D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9" "Platelet degranulation" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation" "4" "0" "0.978" "0.987" "0.973" "0.988" "1.013" "0.993" "0.940" "0.971" "0.987" "2418.4" "2365.0" "2388.0" "2353.1" "2388.5" "2449.9" "2402.3" "2273.2" "2348.7" "2386.9" "" "" "" "" "" "" "" "" "" "" "1942.5" "1706.5" "1896.9" "1576.6" "1651.9" "1838.1" "1681.9" "1660.1" "2348.7" "1941.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6072286448447602827" "False" "High" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "0.000" "False" "95.382" "48" "15" "32" "15" "346" "38.4" "5.30" "108.11" "15" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "" "2" "0" "0.964" "0.981" "0.931" "0.935" "0.915" "0.953" "0.938" "0.915" "0.923" "4529.1" "4368.0" "4443.6" "4218.7" "4236.0" "4143.8" "4314.1" "4249.3" "4145.8" "4178.5" "" "" "" "" "" "" "" "" "" "" "3637.7" "3151.8" "3529.7" "2826.5" "2929.7" "3109.0" "3020.5" "3103.2" "4145.8" "3398.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3313635736816900772" "False" "High" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "0.000" "False" "95.259" "39" "14" "35" "14" "429" "47.4" "5.60" "104.60" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; HATs acetylate histones; DNA Damage Recognition in GG-NER" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "10" "0" "0.972" "0.996" "0.990" "1.056" "1.026" "1.008" "1.079" "1.037" "0.960" "2575.3" "2504.2" "2564.4" "2548.9" "2719.3" "2642.7" "2594.8" "2779.2" "2669.6" "2472.3" "" "" "" "" "" "" "" "" "" "" "2068.4" "1807.0" "2037.0" "1707.7" "1880.7" "1982.7" "1816.7" "2029.7" "2669.6" "2010.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4048246386295190521" "False" "High" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "0.000" "False" "95.192" "32" "12" "25" "6" "443" "49.3" "5.69" "92.62" "12" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "Apoptotic cleavage of cellular proteins" "" "2" "1" "1.068" "1.061" "1.067" "1.025" "1.048" "1.112" "1.000" "1.106" "1.076" "993.0" "1060.6" "1053.5" "1059.5" "1017.8" "1040.9" "1104.6" "993.3" "1098.0" "1068.5" "" "" "" "" "" "" "" "" "" "" "797.6" "765.3" "836.9" "709.9" "703.9" "780.9" "773.4" "725.4" "1098.0" "868.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832137807520605002" "False" "High" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "0.000" "False" "95.186" "32" "20" "23" "20" "754" "84.9" "6.90" "72.74" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf00533, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "29" "0" "0.985" "0.945" "0.991" "0.987" "0.955" "0.875" "0.911" "0.873" "0.967" "1790.4" "1762.8" "1691.1" "1773.9" "1767.2" "1709.2" "1566.4" "1630.5" "1562.5" "1731.1" "" "" "" "" "" "" "" "" "" "" "1438.1" "1272.0" "1343.3" "1188.5" "1222.2" "1282.4" "1096.7" "1190.8" "1562.5" "1407.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2201882454177381815" "False" "High" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "0.000" "False" "95.168" "61" "8" "35" "8" "154" "16.8" "5.24" "123.02" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287, Pf21485" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Hypusine synthesis from eIF5A-lysine" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "3" "0" "1.070" "1.075" "0.993" "0.933" "1.013" "0.982" "1.039" "0.984" "0.991" "3498.3" "3744.9" "3761.2" "3474.4" "3264.9" "3545.5" "3434.9" "3633.4" "3441.1" "3465.1" "" "" "" "" "" "" "" "" "" "" "2809.8" "2702.2" "2987.6" "2327.8" "2258.0" "2660.1" "2405.0" "2653.5" "3441.1" "2818.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3497794903438612376" "False" "High" "IsMasterProtein" "Q92541" "RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4" "0.000" "False" "94.942" "25" "18" "26" "18" "710" "80.3" "8.15" "84.50" "18" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity" "Pf03126" "23168" "ENSG00000137815" "RTF1" "hsa:23168; Q92541; Q96BX6" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "5" "0" "0.965" "0.944" "0.932" "0.898" "0.977" "0.955" "0.988" "0.978" "0.974" "3529.0" "3406.4" "3332.3" "3289.3" "3170.3" "3446.5" "3369.6" "3486.3" "3452.5" "3438.8" "" "" "" "" "" "" "" "" "" "" "2834.4" "2458.0" "2647.0" "2203.8" "2192.6" "2585.8" "2359.3" "2546.1" "3452.5" "2796.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3295496481374294049" "False" "High" "IsMasterProtein" "Q9UHD9" "Ubiquilin-2 OS=Homo sapiens OX=9606 GN=UBQLN2 PE=1 SV=2" "0.000" "False" "94.857" "24" "9" "19" "5" "624" "65.7" "5.22" "82.93" "9" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29978" "ENSG00000188021" "UBQLN2" "hsa:29978; O94798; Q5D027; Q9H3W6; Q9HAZ4; Q9UHD9" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "4" "1.021" "1.021" "1.047" "1.042" "1.019" "1.062" "1.057" "0.980" "1.020" "644.6" "657.9" "658.1" "675.0" "671.9" "656.9" "684.3" "681.1" "631.9" "657.2" "" "" "" "" "" "" "" "" "" "" "517.7" "474.7" "522.7" "452.3" "464.7" "492.8" "479.1" "497.4" "631.9" "534.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7237194878275625611" "False" "High" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "0.000" "False" "94.702" "61" "14" "28" "14" "244" "28.1" "6.65" "91.44" "14" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "tRNA processing in the nucleus" "" "1" "0" "1.011" "0.993" "0.987" "1.008" "1.025" "1.070" "0.977" "1.070" "1.031" "2455.5" "2482.8" "2438.7" "2423.8" "2474.0" "2516.3" "2626.9" "2397.8" "2626.4" "2531.3" "" "" "" "" "" "" "" "" "" "" "1972.3" "1791.5" "1937.1" "1624.0" "1711.0" "1887.9" "1839.2" "1751.1" "2626.4" "2058.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2931302988534192752" "False" "High" "IsMasterProtein" "Q53QZ3" "Rho GTPase-activating protein 15 OS=Homo sapiens OX=9606 GN=ARHGAP15 PE=1 SV=2" "0.000" "False" "94.684" "39" "17" "27" "17" "475" "54.5" "9.39" "81.59" "17" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00169, Pf00620" "55843" "ENSG00000075884" "ARHGAP15" "hsa:55843; Q53QZ3; Q53R36; Q53RD7; Q53RT6; Q53SX9; Q584N9; Q6PJE6; Q86WP1; Q8IXX1; Q9NRL8; Q9NZ77; Q9NZ91" "RAC1 GTPase cycle; RAC3 GTPase cycle" "Ectoderm differentiation; Ectoderm differentiation" "4" "0" "0.985" "0.975" "0.946" "0.923" "0.916" "0.926" "0.942" "0.903" "0.958" "2161.7" "2129.9" "2108.2" "2044.3" "1995.6" "1979.4" "2001.3" "2036.6" "1952.4" "2070.1" "" "" "" "" "" "" "" "" "" "" "1736.3" "1536.9" "1674.6" "1369.7" "1380.1" "1485.1" "1401.2" "1487.4" "1952.4" "1683.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2563545888999241244" "False" "High" "IsMasterProtein" "Q9P2D3" "HEAT repeat-containing protein 5B OS=Homo sapiens OX=9606 GN=HEATR5B PE=1 SV=2" "0.000" "False" "94.647" "12" "20" "23" "20" "2071" "224.2" "7.17" "65.32" "20" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf20210" "54497" "ENSG00000008869" "HEATR5B" "B5MDU8; hsa:54497; Q7Z3B2; Q9NVL7; Q9P2D3" "" "" "0" "0" "1.004" "1.002" "1.045" "0.983" "0.988" "0.965" "0.986" "1.050" "1.017" "1518.6" "1524.1" "1521.7" "1586.6" "1493.3" "1500.1" "1465.3" "1496.6" "1594.1" "1543.8" "" "" "" "" "" "" "" "" "" "" "1219.7" "1099.8" "1208.8" "1063.0" "1032.8" "1125.5" "1025.9" "1093.0" "1594.1" "1255.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4191413839330820481" "False" "High" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "0.000" "False" "94.625" "34" "13" "39" "11" "420" "46.4" "9.57" "127.46" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "2" "1.085" "1.061" "1.049" "1.040" "1.096" "1.066" "1.056" "1.024" "1.044" "4384.4" "4758.0" "4653.0" "4597.3" "4561.4" "4807.3" "4672.6" "4631.7" "4489.6" "4578.8" "" "" "" "" "" "" "" "" "" "" "3521.5" "3433.2" "3696.0" "3080.2" "3154.7" "3606.8" "3271.5" "3382.5" "4489.6" "3723.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3259999118554299265" "False" "High" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "0.000" "False" "94.559" "38" "16" "36" "15" "437" "50.6" "8.63" "107.41" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "MAPK6/MAPK4 signaling" "" "1" "1" "1.021" "1.016" "1.037" "0.999" "0.982" "0.973" "0.986" "1.032" "1.000" "2679.0" "2734.2" "2721.2" "2778.9" "2676.8" "2629.7" "2607.5" "2640.4" "2765.2" "2677.8" "" "" "" "" "" "" "" "" "" "" "2151.7" "1972.9" "2161.6" "1861.9" "1851.3" "1973.0" "1825.7" "1928.3" "2765.2" "2177.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330394968015135701" "False" "High" "IsMasterProtein" "Q9P2R3" "Rabankyrin-5 OS=Homo sapiens OX=9606 GN=ANKFY1 PE=1 SV=2" "0.000" "False" "94.510" "17" "16" "25" "15" "1169" "128.3" "6.10" "85.70" "16" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00023, Pf00651, Pf01363, Pf12796" "51479" "ENSG00000185722" "ANKFY1" "A8KA65; hsa:51479; Q5RKV4; Q9P2R3; Q9ULG5" "RHOD GTPase cycle" "" "1" "0" "0.978" "1.031" "1.037" "1.001" "0.970" "1.064" "0.984" "1.041" "1.041" "1638.5" "1603.3" "1689.6" "1698.9" "1639.8" "1589.8" "1743.9" "1612.6" "1705.3" "1706.5" "" "" "" "" "" "" "" "" "" "" "1316.0" "1156.9" "1342.1" "1138.2" "1134.1" "1192.8" "1221.0" "1177.7" "1705.3" "1387.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1669697587989024487" "False" "High" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "0.000" "False" "94.481" "50" "10" "25" "10" "271" "31.3" "4.94" "100.76" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "Ub-specific processing proteases; Ovarian tumor domain proteases" "" "2" "0" "0.987" "1.019" "0.925" "0.973" "1.016" "0.892" "0.946" "1.040" "0.955" "1914.8" "1890.5" "1950.3" "1772.2" "1863.7" "1946.4" "1707.6" "1810.6" "1992.4" "1827.8" "" "" "" "" "" "" "" "" "" "" "1538.0" "1364.1" "1549.2" "1187.3" "1288.9" "1460.3" "1195.6" "1322.3" "1992.4" "1486.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8070677658803742602" "False" "High" "IsMasterProtein" "P20585" "DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4" "0.000" "False" "94.438" "18" "16" "22" "15" "1137" "127.3" "8.02" "71.73" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05192" "4437" "ENSG00000113318" "MSH3" "A1L480; A1L482; A6NMM6; hsa:4437; P20585; Q6PJT5; Q86UQ6; Q92867" "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2" "Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network" "5" "0" "0.988" "0.995" "1.001" "0.990" "0.976" "0.976" "1.012" "0.936" "0.959" "969.6" "958.1" "965.0" "970.2" "959.9" "946.2" "946.3" "981.4" "907.9" "929.5" "" "" "" "" "" "" "" "" "" "" "778.8" "691.4" "766.6" "650.1" "663.9" "709.9" "662.5" "716.7" "907.9" "755.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5432753500567823498" "False" "High" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "0.000" "False" "94.342" "32" "14" "83" "14" "466" "51.7" "8.32" "218.61" "14" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.948" "0.950" "0.910" "0.924" "0.926" "0.908" "0.907" "0.912" "0.926" "5412.3" "5130.2" "5142.2" "4923.5" "5000.6" "5013.7" "4915.8" "4907.0" "4934.3" "5010.9" "" "" "" "" "" "" "" "" "" "" "4347.1" "3701.8" "4084.6" "3298.7" "3458.5" "3761.7" "3441.8" "3583.6" "4934.3" "4075.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996952704107557877" "False" "High" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "0.000" "False" "94.325" "28" "15" "19" "15" "727" "79.4" "6.23" "69.54" "15" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "1.061" "1.013" "1.064" "1.121" "1.034" "0.978" "1.081" "1.079" "1.070" "1309.8" "1389.1" "1327.3" "1394.2" "1468.4" "1353.9" "1280.7" "1416.2" "1412.7" "1401.4" "" "" "" "" "" "" "" "" "" "" "1052.0" "1002.4" "1054.3" "934.1" "1015.5" "1015.8" "896.7" "1034.2" "1412.7" "1139.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3959098677357932626" "False" "High" "IsMasterProtein" "O43747" "AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5" "0.000" "False" "94.235" "28" "22" "26" "21" "822" "91.3" "6.80" "84.70" "22" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01602, Pf02883" "164" "ENSG00000166747" "AP1G1" "hsa:164; O43747; O75709; O75842; Q9UG09; Q9Y3U4" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "1" "0.977" "1.011" "0.971" "0.964" "0.992" "0.933" "0.994" "1.004" "1.003" "3308.0" "3231.5" "3344.4" "3211.6" "3187.4" "3281.2" "3086.8" "3288.8" "3320.5" "3319.2" "" "" "" "" "" "" "" "" "" "" "2657.0" "2331.8" "2656.6" "2151.8" "2204.4" "2461.8" "2161.2" "2401.8" "3320.5" "2699.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-478504765432675351" "False" "High" "IsMasterProtein" "P30520" "Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3" "0.000" "False" "94.065" "38" "13" "23" "13" "456" "50.1" "6.55" "79.94" "13" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00709" "159" "ENSG00000035687" "ADSS2" "B1AQM5; hsa:159; P30520; Q96EG7" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "1.002" "0.975" "0.958" "1.002" "0.985" "0.943" "0.975" "0.975" "0.960" "2059.9" "2064.5" "2007.6" "1972.4" "2063.5" "2029.5" "1942.1" "2009.0" "2008.9" "1977.5" "" "" "" "" "" "" "" "" "" "" "1654.5" "1489.7" "1594.7" "1321.5" "1427.1" "1522.7" "1359.8" "1467.1" "2008.9" "1608.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4038126070754837566" "False" "High" "IsMasterProtein" "Cont_Q3SYV4" "Adenylyl cyclase-associated protein 1 OS=Bos taurus OX=9913 GN=CAP1 PE=2 SV=3" "0.000" "True" "94.013" "25" "11" "34" "1" "472" "51.2" "7.52" "104.54" "11" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "109556455; 504519" "" "CAP1" "A0A6P5BIK1; biu:109556455; bta:504519; Q3SYV4" "" "" "0" "0" "1.001" "1.085" "0.937" "1.139" "0.993" "1.192" "1.192" "0.894" "1.118" "318.5" "318.8" "345.6" "298.5" "362.7" "316.3" "379.5" "379.8" "284.6" "356.1" "" "" "" "" "" "" "" "" "" "" "255.8" "230.0" "274.5" "200.0" "250.8" "237.3" "265.7" "277.4" "284.6" "289.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958719848471143183" "False" "High" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "0.000" "False" "93.875" "30" "10" "37" "10" "386" "42.9" "5.30" "120.36" "10" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Branched-chain amino acid catabolism" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways" "4" "0" "1.012" "1.004" "0.963" "0.921" "0.964" "0.841" "0.820" "0.910" "0.912" "3024.8" "3061.2" "3037.4" "2913.0" "2787.2" "2916.0" "2542.6" "2481.8" "2751.3" "2757.8" "" "" "" "" "" "" "" "" "" "" "2429.5" "2208.9" "2412.7" "1951.7" "1927.7" "2187.8" "1780.2" "1812.5" "2751.3" "2242.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388316332710741736" "False" "High" "IsMasterProtein" "Q96FS4" "Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1" "0.000" "False" "93.867" "22" "15" "19" "15" "1042" "112.1" "6.60" "72.35" "15" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf21022" "6494" "ENSG00000213445" "SIPA1" "hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4" "Rap1 signalling" "MAPK cascade" "2" "0" "0.975" "0.985" "1.130" "1.104" "1.037" "1.167" "1.110" "1.060" "1.056" "1436.4" "1399.9" "1414.2" "1623.5" "1585.6" "1490.2" "1675.8" "1594.3" "1522.5" "1516.8" "" "" "" "" "" "" "" "" "" "" "1153.7" "1010.1" "1123.4" "1087.8" "1096.6" "1118.1" "1173.3" "1164.3" "1522.5" "1233.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4723246947420564514" "False" "High" "IsMasterProtein" "O94915" "Protein furry homolog-like OS=Homo sapiens OX=9606 GN=FRYL PE=1 SV=2" "0.000" "False" "93.653" "8" "22" "24" "21" "3013" "339.4" "5.58" "70.21" "22" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf14222, Pf14225, Pf14228, Pf19421" "285527" "ENSG00000075539" "FRYL" "hsa:285527; O94915; O95640; Q8WTZ5; Q9NT40" "" "" "0" "0" "1.062" "1.040" "1.000" "0.955" "0.982" "0.923" "1.030" "0.979" "0.996" "1486.1" "1578.1" "1544.8" "1486.4" "1419.2" "1458.9" "1371.3" "1530.9" "1454.3" "1479.6" "" "" "" "" "" "" "" "" "" "" "1193.6" "1138.7" "1227.1" "995.9" "981.5" "1094.6" "960.1" "1118.0" "1454.3" "1203.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737911317243548471" "False" "High" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "0.000" "False" "93.608" "48" "14" "25" "14" "228" "26.2" "6.44" "94.43" "14" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "Small interfering RNA (siRNA) biogenesis" "" "1" "0" "0.988" "0.982" "0.965" "0.974" "1.006" "0.894" "0.918" "0.950" "0.997" "2318.2" "2291.4" "2277.2" "2236.6" "2257.4" "2331.1" "2072.2" "2126.9" "2201.2" "2311.5" "" "" "" "" "" "" "" "" "" "" "1861.9" "1653.4" "1808.9" "1498.5" "1561.2" "1749.0" "1450.8" "1553.3" "2201.2" "1879.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154520297388586765" "False" "High" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "0.000" "False" "93.597" "34" "15" "23" "15" "563" "61.3" "7.68" "76.65" "15" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "Biotin transport and metabolism; Branched-chain amino acid catabolism; Defective HLCS causes multiple carboxylase deficiency" "" "3" "0" "1.012" "0.993" "0.946" "1.060" "1.007" "0.961" "0.974" "1.012" "1.024" "1308.1" "1324.0" "1299.0" "1237.3" "1386.7" "1317.3" "1257.6" "1274.3" "1323.2" "1338.8" "" "" "" "" "" "" "" "" "" "" "1050.7" "955.4" "1031.9" "829.0" "959.1" "988.4" "880.5" "930.6" "1323.2" "1088.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1597744866915900932" "False" "High" "IsMasterProtein" "P51114" "RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "0.000" "False" "93.378" "24" "14" "23" "12" "621" "69.7" "6.15" "87.49" "14" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Signaling by BRAF and RAF1 fusions" "Bile acids synthesis and enterohepatic circulation" "2" "1" "0.983" "1.011" "1.063" "1.051" "1.074" "1.052" "1.034" "1.055" "1.051" "2080.8" "2045.9" "2103.1" "2210.9" "2187.4" "2235.8" "2190.0" "2152.4" "2196.1" "2186.9" "" "" "" "" "" "" "" "" "" "" "1671.3" "1476.3" "1670.6" "1481.3" "1512.8" "1677.5" "1533.3" "1571.9" "2196.1" "1778.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2982172693089125932" "False" "High" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "0.000" "False" "93.291" "51" "9" "31" "9" "241" "26.4" "4.79" "108.91" "9" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "Downstream TCR signaling; UCH proteinases; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "0.928" "0.978" "0.889" "0.960" "1.026" "0.908" "0.962" "0.950" "0.973" "3418.4" "3171.0" "3341.8" "3039.6" "3280.1" "3508.8" "3105.3" "3287.1" "3248.7" "3326.6" "" "" "" "" "" "" "" "" "" "" "2745.6" "2288.1" "2654.5" "2036.5" "2268.6" "2632.6" "2174.1" "2400.6" "3248.7" "2705.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376641896775859350" "False" "High" "IsMasterProtein" "O95104" "SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" "0.000" "False" "93.203" "12" "12" "22" "12" "1147" "125.8" "9.55" "85.77" "12" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "57466" "ENSG00000156304" "SCAF4" "C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8" "" "" "0" "0" "1.011" "1.063" "1.042" "1.025" "1.039" "1.008" "1.125" "1.106" "1.085" "1891.2" "1912.1" "2009.9" "1971.3" "1938.8" "1964.6" "1905.7" "2127.7" "2092.3" "2051.5" "" "" "" "" "" "" "" "" "" "" "1519.0" "1379.7" "1596.5" "1320.8" "1340.9" "1474.0" "1334.2" "1553.9" "2092.3" "1668.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7657012177295081485" "False" "High" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "0.000" "False" "93.193" "46" "12" "31" "12" "328" "37.1" "6.84" "116.16" "12" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "12" "0" "0.966" "0.984" "0.996" "1.037" "0.972" "0.975" "0.996" "1.014" "0.976" "2721.9" "2630.2" "2678.6" "2711.7" "2823.3" "2646.9" "2654.2" "2711.3" "2760.9" "2656.4" "" "" "" "" "" "" "" "" "" "" "2186.2" "1897.9" "2127.7" "1816.9" "1952.6" "1985.9" "1858.3" "1980.1" "2760.9" "2160.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5829960447854698720" "False" "High" "IsMasterProtein" "O43399" "Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2" "0.000" "False" "93.162" "55" "11" "25" "11" "206" "22.2" "5.36" "88.19" "11" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf04201" "7165" "ENSG00000101150" "TPD52L2" "B4DPJ6; E1P5G7; hsa:7165; O43398; O43399; Q5JWU5; Q5JWU6; Q5JWU8; Q5U0E0; Q9H3Z6" "" "" "0" "0" "1.055" "1.079" "1.088" "1.062" "1.106" "1.154" "1.073" "1.114" "1.064" "2300.6" "2426.2" "2481.3" "2502.5" "2443.9" "2544.7" "2655.6" "2467.9" "2563.4" "2447.2" "" "" "" "" "" "" "" "" "" "" "1847.8" "1750.7" "1971.0" "1676.7" "1690.2" "1909.3" "1859.3" "1802.3" "2563.4" "1990.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8315542899134672596" "False" "High" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "0.000" "False" "93.144" "22" "20" "32" "18" "968" "112.1" "6.95" "96.91" "20" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "" "4" "0" "1.016" "0.988" "0.984" "0.957" "0.998" "1.008" "1.006" "1.007" "0.980" "2291.5" "2329.0" "2263.3" "2255.5" "2192.1" "2287.7" "2310.6" "2305.4" "2307.3" "2246.1" "" "" "" "" "" "" "" "" "" "" "1840.5" "1680.5" "1797.8" "1511.2" "1516.1" "1716.4" "1617.7" "1683.6" "2307.3" "1826.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4232598259152992278" "False" "High" "IsMasterProtein" "Q86Y56" "Dynein axonemal assembly factor 5 OS=Homo sapiens OX=9606 GN=DNAAF5 PE=1 SV=4" "0.000" "False" "93.139" "28" "21" "28" "21" "855" "93.5" "6.42" "93.52" "21" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf02985" "54919" "ENSG00000164818" "DNAAF5" "hsa:54919; Q69YL1; Q86Y56; Q96FI9; Q9NX75" "" "Ciliopathies" "1" "0" "0.986" "0.961" "0.988" "0.950" "0.940" "0.903" "0.953" "0.888" "0.931" "1603.1" "1580.0" "1540.5" "1584.6" "1522.8" "1507.5" "1448.4" "1528.2" "1423.7" "1493.0" "" "" "" "" "" "" "" "" "" "" "1287.6" "1140.0" "1223.6" "1061.7" "1053.1" "1131.0" "1014.1" "1116.1" "1423.7" "1214.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3973865475325375053" "False" "High" "IsMasterProtein" "P15374" "Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1" "0.000" "False" "93.088" "49" "9" "24" "9" "230" "26.2" "4.92" "91.59" "9" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01088" "7347" "ENSG00000118939" "UCHL3" "B2R970; hsa:7347; P15374; Q5TBK8; Q6IBE9" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation" "Proteasome degradation" "4" "0" "0.966" "0.982" "1.008" "1.039" "1.024" "1.055" "0.991" "0.984" "1.017" "1797.0" "1736.7" "1765.1" "1812.2" "1866.7" "1839.8" "1895.5" "1781.6" "1769.0" "1827.4" "" "" "" "" "" "" "" "" "" "" "1443.3" "1253.2" "1402.1" "1214.1" "1291.0" "1380.4" "1327.1" "1301.1" "1769.0" "1486.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6335847497915133656" "False" "High" "IsMasterProtein" "Q9BTY7" "Protein HGH1 homolog OS=Homo sapiens OX=9606 GN=HGH1 PE=1 SV=1" "0.000" "False" "93.047" "49" "15" "23" "15" "390" "42.1" "4.81" "86.04" "15" "" "" "" "Pf04063, Pf04064" "51236" "ENSG00000235173" "HGH1" "hsa:51236; P0CB43; Q9BTY7" "" "" "0" "0" "0.992" "1.004" "1.072" "0.979" "1.013" "0.974" "0.934" "0.974" "1.002" "770.0" "764.0" "773.0" "825.2" "754.0" "779.9" "749.8" "719.0" "749.9" "771.3" "" "" "" "" "" "" "" "" "" "" "618.5" "551.2" "614.0" "552.9" "521.5" "585.2" "525.0" "525.1" "749.9" "627.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028893805167112372" "False" "High" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "0.000" "False" "92.653" "43" "17" "27" "13" "444" "49.3" "7.23" "87.40" "17" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "3" "1.025" "1.046" "1.010" "0.988" "1.029" "0.991" "1.011" "1.016" "1.017" "2100.1" "2153.4" "2196.7" "2120.6" "2075.4" "2160.2" "2081.4" "2123.9" "2133.3" "2136.7" "" "" "" "" "" "" "" "" "" "" "1686.8" "1553.8" "1744.9" "1420.8" "1435.4" "1620.7" "1457.3" "1551.1" "2133.3" "1737.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1088137077242897803" "False" "High" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "0.000" "False" "92.618" "20" "11" "15" "11" "736" "79.6" "8.84" "61.53" "11" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "10" "0" "1.014" "1.001" "1.077" "1.231" "1.121" "1.065" "1.127" "1.268" "1.067" "1183.7" "1200.5" "1184.6" "1274.8" "1457.1" "1327.4" "1260.5" "1333.6" "1501.2" "1263.2" "" "" "" "" "" "" "" "" "" "" "950.7" "866.2" "941.0" "854.1" "1007.7" "995.9" "882.5" "973.9" "1501.2" "1027.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1679721907195940966" "False" "High" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "0.000" "False" "92.535" "31" "10" "37" "10" "369" "41.3" "5.27" "118.33" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "1.089" "1.068" "1.041" "1.034" "1.089" "1.040" "1.072" "1.099" "1.065" "3186.2" "3470.2" "3402.5" "3318.4" "3293.6" "3471.4" "3314.2" "3414.6" "3501.9" "3394.8" "" "" "" "" "" "" "" "" "" "" "2559.1" "2504.0" "2702.7" "2223.3" "2277.9" "2604.5" "2320.4" "2493.7" "3501.9" "2760.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7522921008615735421" "False" "High" "IsMasterProtein" "O75152" "Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3" "0.000" "False" "92.482" "25" "18" "21" "18" "810" "89.1" "8.37" "78.21" "18" "other metabolic processes;transport" "nucleus" "other molecular function" "Pf15663" "9877" "ENSG00000058673" "ZC3H11A" "hsa:9877; O75152; Q6AHY4; Q6AHY9; Q6AW79; Q6AWA1; Q6PJK4; Q86XZ7" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.027" "1.013" "1.039" "1.094" "1.033" "0.950" "0.946" "0.980" "1.036" "1321.9" "1357.6" "1339.3" "1373.8" "1446.7" "1364.9" "1255.4" "1250.8" "1295.1" "1369.0" "" "" "" "" "" "" "" "" "" "" "1061.7" "979.6" "1063.9" "920.5" "1000.6" "1024.1" "879.0" "913.5" "1295.1" "1113.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8155016399758939464" "False" "High" "IsMasterProtein" "Q9UNS1" "Protein timeless homolog OS=Homo sapiens OX=9606 GN=TIMELESS PE=1 SV=2" "0.000" "False" "92.314" "18" "17" "19" "17" "1208" "138.6" "5.40" "64.09" "17" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04821, Pf05029" "8914" "ENSG00000111602" "TIMELESS" "B2ZAV0; hsa:8914; O94802; Q86VM1; Q8IWH3; Q9UNS1" "Processing of DNA double-strand break ends" "" "1" "0" "1.062" "1.049" "0.997" "1.013" "1.008" "1.017" "1.121" "1.184" "1.062" "1391.9" "1477.8" "1460.5" "1387.7" "1410.0" "1402.5" "1416.2" "1560.3" "1648.4" "1478.1" "" "" "" "" "" "" "" "" "" "" "1118.0" "1066.4" "1160.1" "929.7" "975.2" "1052.3" "991.5" "1139.5" "1648.4" "1202.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-767357545140157834" "False" "High" "IsMasterProtein" "P51784" "Ubiquitin carboxyl-terminal hydrolase 11 OS=Homo sapiens OX=9606 GN=USP11 PE=1 SV=3" "0.000" "False" "92.117" "22" "19" "26" "17" "963" "109.7" "5.45" "82.67" "19" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "" "ENSG00000102226" "USP11" "B2RTX1; P51784; Q8IUG6; Q9BWE1" "Ub-specific processing proteases; Association of TriC/CCT with target proteins during biosynthesis" "" "2" "0" "0.990" "0.970" "1.006" "0.974" "0.938" "1.066" "1.038" "1.002" "1.034" "1599.8" "1583.1" "1552.3" "1609.5" "1558.3" "1500.7" "1705.5" "1660.6" "1602.6" "1653.7" "" "" "" "" "" "" "" "" "" "" "1284.9" "1142.3" "1233.0" "1078.4" "1077.7" "1125.9" "1194.1" "1212.8" "1602.6" "1344.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002494153914850513" "False" "High" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "0.000" "False" "91.921" "38" "8" "14" "8" "324" "37.0" "6.77" "63.59" "8" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Neutrophil degranulation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "0.945" "0.965" "0.950" "0.936" "0.919" "0.950" "0.949" "0.889" "0.917" "1160.7" "1096.9" "1119.6" "1102.3" "1086.7" "1066.7" "1102.6" "1100.9" "1032.4" "1064.7" "" "" "" "" "" "" "" "" "" "" "932.2" "791.5" "889.4" "738.5" "751.6" "800.3" "772.0" "804.0" "1032.4" "865.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8621700409293052339" "False" "High" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "0.000" "False" "91.875" "27" "14" "38" "14" "584" "65.4" "7.61" "114.03" "14" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle in senescence" "3" "0" "1.037" "1.015" "0.969" "0.969" "0.991" "0.884" "0.934" "0.954" "0.988" "3314.5" "3437.9" "3363.6" "3212.7" "3212.3" "3285.2" "2930.2" "3094.5" "3163.2" "3274.8" "" "" "" "" "" "" "" "" "" "" "2662.2" "2480.7" "2671.8" "2152.5" "2221.6" "2464.8" "2051.6" "2259.9" "3163.2" "2663.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154777414140805672" "False" "High" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "0.000" "False" "91.830" "26" "15" "26" "15" "708" "76.5" "5.07" "91.80" "15" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "" "2" "0" "1.052" "1.026" "1.103" "1.073" "1.052" "1.071" "1.064" "1.053" "1.039" "1278.6" "1344.7" "1312.2" "1410.1" "1372.3" "1345.5" "1369.9" "1359.8" "1345.9" "1328.7" "" "" "" "" "" "" "" "" "" "" "1026.9" "970.3" "1042.3" "944.8" "949.1" "1009.5" "959.1" "993.1" "1345.9" "1080.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7459111357476572255" "False" "High" "IsMasterProtein" "Q8NFY9" "Kelch repeat and BTB domain-containing protein 8 OS=Homo sapiens OX=9606 GN=KBTBD8 PE=1 SV=2" "0.000" "False" "91.699" "33" "16" "26" "16" "601" "68.8" "6.29" "88.39" "16" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "84541" "ENSG00000163376" "KBTBD8" "B4DTW6; hsa:84541; Q8NFY9; Q96JI5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.010" "0.967" "1.026" "1.112" "1.016" "1.065" "1.050" "1.072" "1.034" "1459.1" "1473.0" "1411.4" "1496.8" "1622.8" "1482.4" "1554.3" "1531.8" "1564.1" "1508.5" "" "" "" "" "" "" "" "" "" "" "1172.0" "1062.9" "1121.1" "1002.9" "1122.4" "1112.2" "1088.2" "1118.7" "1564.1" "1226.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8633064063620321085" "False" "High" "IsMasterProtein" "Q6PGP7" "Superkiller complex protein 3 OS=Homo sapiens OX=9606 GN=SKIC3 PE=1 SV=1" "0.000" "False" "91.653" "13" "20" "25" "20" "1564" "175.4" "7.53" "86.44" "20" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf13181, Pf13432, Pf14559" "9652" "ENSG00000198677" "SKIC3" "hsa:9652; O15077; Q6PGP7; Q6PJI3" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "0.962" "0.963" "0.902" "0.904" "0.941" "0.882" "0.912" "0.907" "0.951" "1683.7" "1619.4" "1621.6" "1518.9" "1521.3" "1584.2" "1485.0" "1536.2" "1526.4" "1600.5" "" "" "" "" "" "" "" "" "" "" "1352.3" "1168.5" "1288.1" "1017.7" "1052.2" "1188.6" "1039.7" "1121.9" "1526.4" "1301.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5185588165699995097" "False" "High" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "0.000" "False" "91.633" "71" "11" "33" "9" "206" "22.2" "9.38" "122.85" "11" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "" "Orexin receptor pathway" "1" "2" "1.118" "1.258" "1.195" "1.155" "0.975" "1.114" "1.246" "1.086" "1.092" "1857.1" "2075.4" "2336.2" "2219.3" "2145.3" "1810.9" "2068.2" "2313.2" "2017.7" "2028.3" "" "" "" "" "" "" "" "" "" "" "1491.6" "1497.5" "1855.7" "1486.9" "1483.7" "1358.7" "1448.0" "1689.4" "2017.7" "1649.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4231086194268643311" "False" "High" "IsMasterProtein" "Q8N6R0" "eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=METTL13 PE=1 SV=1" "0.000" "False" "91.606" "25" "14" "18" "14" "699" "78.7" "6.73" "68.98" "14" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01564, Pf13847" "51603" "ENSG00000010165" "METTL13" "A6NFK0; A8K6S5; hsa:51603; O94940; Q53EZ6; Q5TGP9; Q5TGQ0; Q8N2P8; Q8N6R0; Q96J11; Q96SQ0; Q9Y2Z1; Q9Y3M6" "" "" "0" "0" "1.017" "0.997" "1.060" "1.050" "0.992" "1.030" "0.965" "0.973" "1.022" "1622.6" "1650.7" "1617.1" "1720.3" "1704.1" "1609.2" "1670.9" "1565.5" "1579.2" "1658.6" "" "" "" "" "" "" "" "" "" "" "1303.2" "1191.1" "1284.6" "1152.6" "1178.5" "1207.3" "1169.9" "1143.3" "1579.2" "1348.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2375108519350628678" "False" "High" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "0.000" "False" "91.605" "42" "18" "37" "12" "482" "55.1" "5.48" "118.03" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "Potential therapeutics for SARS; Estrogen-dependent gene expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Nuclear events stimulated by ALK signaling in cancer; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; TGF-beta signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome; Effect of progerin on genes involved in progeria; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "56" "5" "1.008" "1.072" "0.962" "0.896" "0.961" "0.937" "1.044" "1.024" "0.982" "2800.8" "2822.0" "3001.8" "2695.3" "2509.9" "2692.4" "2624.6" "2923.0" "2866.7" "2750.6" "" "" "" "" "" "" "" "" "" "" "2249.6" "2036.3" "2384.4" "1805.8" "1735.8" "2020.0" "1837.6" "2134.7" "2866.7" "2236.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7835862942369075388" "False" "High" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "0.000" "False" "91.551" "42" "15" "45" "3" "285" "32.9" "4.72" "136.88" "15" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Striated Muscle Contraction" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "7" "2" "0.980" "0.941" "1.019" "1.024" "1.010" "1.080" "1.031" "0.999" "0.979" "1937.3" "1897.9" "1822.9" "1973.6" "1984.5" "1957.3" "2092.8" "1997.7" "1935.9" "1897.3" "" "" "" "" "" "" "" "" "" "" "1556.0" "1369.5" "1448.0" "1322.3" "1372.5" "1468.5" "1465.3" "1458.9" "1935.9" "1542.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6598258105920115633" "False" "High" "IsMasterProtein" "Q5TDH0" "Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1" "0.000" "False" "91.434" "42" "10" "16" "10" "399" "44.5" "5.05" "58.04" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf09668" "84301" "ENSG00000197312" "DDI2" "A8KAE1; hsa:84301; Q5TDH0; Q7RTZ0; Q9BRT1" "" "" "0" "0" "0.982" "0.970" "1.131" "1.142" "0.931" "1.178" "1.085" "1.039" "1.060" "872.5" "856.8" "846.4" "986.9" "996.7" "812.3" "1027.8" "947.0" "906.4" "924.8" "" "" "" "" "" "" "" "" "" "" "700.8" "618.2" "672.3" "661.2" "689.3" "609.4" "719.6" "691.6" "906.4" "752.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5539470002617871814" "False" "High" "IsMasterProtein" "Q9P2R7" "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" "0.000" "False" "91.367" "32" "17" "32" "16" "463" "50.3" "7.42" "106.24" "17" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8803" "ENSG00000136143" "SUCLA2" "B2RDE7; hsa:8803; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; Q9P2R7" "Citric acid cycle (TCA cycle)" "" "1" "0" "1.030" "0.987" "0.968" "0.942" "0.956" "0.912" "0.926" "0.963" "0.944" "2734.9" "2817.2" "2698.7" "2647.4" "2576.2" "2613.5" "2494.8" "2533.3" "2634.0" "2582.8" "" "" "" "" "" "" "" "" "" "" "2196.6" "2032.8" "2143.7" "1773.7" "1781.7" "1960.8" "1746.7" "1850.1" "2634.0" "2100.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5905184492137342602" "False" "High" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "0.000" "False" "91.365" "33" "16" "34" "16" "390" "43.3" "8.06" "100.37" "16" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "17" "0" "0.997" "0.983" "0.933" "0.968" "0.993" "0.908" "0.927" "0.982" "0.977" "2907.7" "2899.7" "2859.3" "2712.6" "2813.9" "2888.8" "2639.1" "2694.4" "2854.8" "2842.2" "" "" "" "" "" "" "" "" "" "" "2335.4" "2092.4" "2271.2" "1817.5" "1946.1" "2167.4" "1847.7" "1967.7" "2854.8" "2311.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5626917880360896955" "False" "High" "IsMasterProtein" "Q8N201" "Integrator complex subunit 1 OS=Homo sapiens OX=9606 GN=INTS1 PE=1 SV=2" "0.000" "False" "91.232" "10" "19" "20" "19" "2190" "244.1" "6.13" "72.66" "19" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus" "" "Pf12432" "26173" "ENSG00000164880" "INTS1" "A6NJ44; hsa:26173; Q6NT70; Q6UX74; Q8N201; Q8WV40; Q96D36; Q9NTD1; Q9P2A8; Q9Y3W8" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.022" "1.048" "1.105" "1.098" "1.041" "1.145" "1.140" "1.070" "1.104" "1344.1" "1373.9" "1408.9" "1485.8" "1475.7" "1398.7" "1538.8" "1532.3" "1438.6" "1483.3" "" "" "" "" "" "" "" "" "" "" "1079.6" "991.4" "1119.1" "995.5" "1020.6" "1049.4" "1077.4" "1119.1" "1438.6" "1206.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321925279742634811" "False" "High" "IsMasterProtein" "Q9Y6Y8" "SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1" "0.000" "False" "91.199" "21" "19" "25" "19" "1000" "111.0" "5.54" "86.67" "19" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "11196" "ENSG00000107651" "SEC23IP" "D3DRD2; hsa:11196; Q8IXH5; Q9BUK5; Q9Y6Y8" "COPII-mediated vesicle transport" "" "1" "0" "0.969" "0.985" "0.990" "0.965" "0.938" "0.905" "0.959" "0.991" "0.967" "2356.3" "2283.7" "2321.8" "2333.6" "2273.6" "2210.7" "2131.7" "2260.4" "2335.1" "2278.1" "" "" "" "" "" "" "" "" "" "" "1892.6" "1647.8" "1844.3" "1563.5" "1572.5" "1658.6" "1492.5" "1650.8" "2335.1" "1852.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4018200245095699536" "False" "High" "IsMasterProtein" "P55327" "Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52 PE=1 SV=2" "0.000" "False" "91.175" "44" "7" "31" "7" "224" "24.3" "4.83" "137.56" "7" "transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf04201" "7163" "ENSG00000076554" "TPD52" "B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4; hsa:7163; P55327; Q13056; Q53EK8; Q6FGP3; Q6FGS3; Q86YZ2; Q9UCX8" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "0.998" "1.004" "0.981" "0.957" "1.036" "1.014" "0.991" "0.952" "0.988" "2679.4" "2673.8" "2689.4" "2628.6" "2564.0" "2777.2" "2718.1" "2654.5" "2551.2" "2648.3" "" "" "" "" "" "" "" "" "" "" "2152.1" "1929.3" "2136.3" "1761.1" "1773.3" "2083.7" "1903.1" "1938.6" "2551.2" "2153.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029493779746441827" "False" "High" "IsMasterProtein" "Q7L1Q6" "eIF5-mimic protein 2 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "0.000" "False" "91.122" "37" "19" "42" "16" "419" "48.0" "5.92" "143.31" "19" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "0.966" "1.000" "0.970" "0.985" "0.941" "0.961" "0.970" "1.019" "0.961" "3721.2" "3595.1" "3722.2" "3607.8" "3665.0" "3500.7" "3574.7" "3607.9" "3791.6" "3576.2" "" "" "" "" "" "" "" "" "" "" "2988.8" "2594.2" "2956.6" "2417.2" "2534.8" "2626.5" "2502.8" "2634.8" "3791.6" "2908.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8545908257350266971" "False" "High" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "0.000" "False" "91.017" "42" "13" "43" "13" "300" "34.3" "7.36" "131.12" "13" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "0.981" "1.021" "0.937" "0.969" "0.996" "0.970" "0.971" "0.971" "0.956" "5588.0" "5481.6" "5703.2" "5238.5" "5415.5" "5568.3" "5419.5" "5425.9" "5424.0" "5341.6" "" "" "" "" "" "" "" "" "" "" "4488.2" "3955.4" "4530.2" "3509.8" "3745.4" "4177.8" "3794.4" "3962.6" "5424.0" "4344.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607274144029287900" "False" "High" "IsMasterProtein" "O14929" "Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2" "0.000" "False" "90.969" "31" "9" "23" "9" "419" "49.5" "5.69" "85.60" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10394, Pf21183" "8520" "ENSG00000128708" "HAT1" "hsa:8520; O14929; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9" "HATs acetylate histones" "Ethanol effects on histone modifications" "2" "0" "0.969" "1.016" "0.968" "0.989" "0.923" "0.986" "1.033" "1.008" "0.963" "2754.6" "2670.4" "2799.9" "2665.3" "2723.2" "2541.9" "2715.7" "2846.1" "2776.3" "2653.1" "" "" "" "" "" "" "" "" "" "" "2212.5" "1926.9" "2224.0" "1785.8" "1883.4" "1907.1" "1901.4" "2078.5" "2776.3" "2157.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7590147556392166876" "False" "High" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "0.000" "False" "90.851" "26" "19" "33" "19" "714" "81.8" "5.67" "111.54" "19" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "P07384; Q2TTR0; Q6DHV4" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "7" "0" "1.064" "1.063" "1.018" "1.062" "1.043" "0.951" "1.040" "1.073" "1.051" "2833.7" "3016.0" "3012.9" "2883.4" "3008.9" "2955.1" "2693.5" "2946.4" "3041.9" "2977.3" "" "" "" "" "" "" "" "" "" "" "2276.0" "2176.3" "2393.3" "1931.9" "2081.0" "2217.1" "1885.9" "2151.8" "3041.9" "2421.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8471595991882746273" "False" "High" "IsMasterProtein" "P35612" "Beta-adducin OS=Homo sapiens OX=9606 GN=ADD2 PE=1 SV=3" "0.000" "False" "90.792" "28" "16" "23" "16" "726" "80.8" "5.92" "77.50" "16" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "119" "ENSG00000075340" "ADD2" "A8K4P2; B4DM17; D6W5G7; D6W5G8; hsa:119; P35612; Q13482; Q16412; Q59G82; Q5U5P4; Q6P0P2; Q6PGQ4; Q7Z688; Q7Z689; Q7Z690; Q7Z691" "Miscellaneous transport and binding events" "" "1" "0" "1.014" "0.990" "0.963" "0.988" "0.982" "0.954" "0.982" "1.014" "0.984" "2543.2" "2578.5" "2518.4" "2447.9" "2512.9" "2496.3" "2427.3" "2497.4" "2578.7" "2503.1" "" "" "" "" "" "" "" "" "" "" "2042.7" "1860.6" "2000.5" "1640.1" "1737.9" "1872.9" "1699.5" "1823.9" "2578.7" "2035.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5588804604694799714" "False" "High" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "0.000" "False" "90.766" "35" "13" "30" "13" "453" "48.7" "8.95" "107.25" "13" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle)" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "10" "0" "0.990" "0.954" "1.003" "1.032" "0.969" "0.956" "0.960" "1.014" "0.948" "1620.2" "1604.4" "1545.3" "1625.7" "1671.9" "1570.6" "1549.6" "1555.9" "1643.0" "1535.4" "" "" "" "" "" "" "" "" "" "" "1301.3" "1157.7" "1227.5" "1089.2" "1156.3" "1178.4" "1084.9" "1136.3" "1643.0" "1248.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6370225409205057848" "False" "High" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "0.000" "False" "90.710" "24" "10" "26" "10" "559" "59.8" "5.29" "80.94" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "mRNA Splicing - Major Pathway" "" "1" "0" "1.073" "1.114" "1.001" "1.029" "1.091" "0.977" "1.035" "1.038" "1.032" "2587.6" "2776.3" "2883.4" "2589.5" "2662.7" "2822.3" "2528.1" "2678.1" "2685.8" "2669.8" "" "" "" "" "" "" "" "" "" "" "2078.3" "2003.3" "2290.4" "1735.0" "1841.6" "2117.5" "1770.1" "1955.8" "2685.8" "2171.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7525494529212049263" "False" "High" "IsMasterProtein" "O43149" "Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6" "0.000" "False" "90.598" "8" "20" "24" "20" "2961" "330.9" "5.95" "87.47" "20" "cell organization and biogenesis" "" "other molecular function" "Pf00569, Pf03256" "23140" "ENSG00000074755" "ZZEF1" "A7MBM5; hsa:23140; O43149; Q6NXG0; Q6ZRA1; Q6ZSF4; Q9NVB9" "" "" "0" "0" "1.030" "0.986" "1.107" "1.038" "1.033" "1.026" "1.041" "1.002" "1.087" "820.8" "845.3" "809.4" "908.2" "851.6" "847.9" "842.3" "854.0" "822.5" "892.2" "" "" "" "" "" "" "" "" "" "" "659.2" "610.0" "642.9" "608.5" "589.0" "636.2" "589.7" "623.7" "822.5" "725.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8904894331141024633" "False" "High" "IsMasterProtein" "Q04726" "Transducin-like enhancer protein 3 OS=Homo sapiens OX=9606 GN=TLE3 PE=1 SV=2" "0.000" "False" "90.531" "26" "15" "27" "15" "772" "83.4" "7.20" "93.68" "15" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7090" "ENSG00000140332" "TLE3" "B4DPT0; E9PD64; F8W964; hsa:7090; Q04726; Q6PI57; Q8IVV6; Q8WVR2; Q9HCM5" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent gene expression; Repression of WNT target genes" "White fat cell differentiation" "5" "0" "1.013" "0.991" "0.939" "0.931" "0.946" "0.868" "0.941" "0.927" "0.964" "1708.4" "1731.0" "1692.7" "1604.6" "1590.6" "1615.6" "1482.3" "1607.4" "1583.0" "1647.7" "" "" "" "" "" "" "" "" "" "" "1372.2" "1249.1" "1344.6" "1075.1" "1100.1" "1212.2" "1037.8" "1173.9" "1583.0" "1340.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2127950675318566661" "False" "High" "IsMasterProtein" "Q9UJA5" "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1" "0.000" "False" "90.225" "32" "17" "27" "17" "497" "55.8" "7.55" "90.62" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf04189" "51605" "ENSG00000089195" "TRMT6" "B4DUV6; hsa:51605; Q76P92; Q9BQV5; Q9UJA5; Q9ULR7; Q9Y2Z8" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.021" "0.982" "0.932" "0.890" "0.945" "0.868" "0.922" "0.921" "0.931" "1582.1" "1615.4" "1553.9" "1475.0" "1407.7" "1495.2" "1372.5" "1459.5" "1457.2" "1472.8" "" "" "" "" "" "" "" "" "" "" "1270.7" "1165.6" "1234.3" "988.2" "973.6" "1121.8" "960.9" "1065.8" "1457.2" "1197.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2703376622299265366" "False" "High" "IsMasterProtein" "Q9UKF6" "Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1" "0.000" "False" "90.146" "31" "19" "26" "19" "684" "77.4" "5.60" "80.29" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07521, Pf10996, Pf11718, Pf16661" "51692" "ENSG00000119203" "CPSF3" "hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "0.988" "1.012" "1.037" "1.027" "1.028" "0.987" "1.037" "1.007" "1.017" "1703.6" "1683.9" "1723.4" "1766.4" "1748.8" "1751.8" "1680.7" "1766.1" "1715.4" "1733.2" "" "" "" "" "" "" "" "" "" "" "1368.3" "1215.1" "1368.9" "1183.5" "1209.5" "1314.4" "1176.8" "1289.8" "1715.4" "1409.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654613729152941586" "False" "High" "IsMasterProtein" "P23786" "Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CPT2 PE=1 SV=2" "0.000" "False" "89.989" "34" "20" "26" "20" "658" "73.7" "8.18" "83.82" "20" "other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00755" "1376" "ENSG00000157184" "CPT2" "B2R6S0; hsa:1376; P23786; Q5SW68; Q9BQ26" "PPARA activates gene expression; Carnitine metabolism" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Thermogenesis; Mitochondrial fatty acid oxidation disorders" "9" "0" "0.998" "0.974" "0.998" "1.078" "0.980" "0.990" "1.034" "1.024" "1.036" "2118.9" "2114.4" "2064.8" "2113.7" "2284.9" "2076.9" "2098.7" "2190.2" "2169.0" "2196.1" "" "" "" "" "" "" "" "" "" "" "1701.9" "1525.7" "1640.1" "1416.2" "1580.3" "1558.3" "1469.4" "1599.5" "2169.0" "1786.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4914593963434688361" "False" "High" "IsMasterProtein" "Q6P3X3" "Tetratricopeptide repeat protein 27 OS=Homo sapiens OX=9606 GN=TTC27 PE=1 SV=1" "0.000" "False" "89.978" "20" "16" "23" "16" "843" "96.6" "5.59" "77.90" "16" "" "" "" "Pf07719" "55622" "ENSG00000018699" "TTC27" "A6NKJ0; hsa:55622; Q6P3X3; Q96SS5; Q9BVF1; Q9NWR4; Q9NXG4" "" "" "0" "0" "0.975" "0.982" "0.999" "0.973" "0.960" "0.970" "0.968" "0.941" "0.972" "1969.0" "1918.9" "1933.7" "1967.6" "1916.3" "1889.4" "1909.8" "1906.3" "1853.6" "1914.5" "" "" "" "" "" "" "" "" "" "" "1581.5" "1384.6" "1536.0" "1318.3" "1325.3" "1417.6" "1337.2" "1392.2" "1853.6" "1556.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1985777424174479704" "False" "High" "IsMasterProtein" "Q14669" "E3 ubiquitin-protein ligase TRIP12 OS=Homo sapiens OX=9606 GN=TRIP12 PE=1 SV=1" "0.000" "False" "89.973" "10" "19" "24" "19" "1992" "220.3" "8.48" "76.18" "19" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00632" "9320" "ENSG00000153827" "TRIP12" "D4HL82; Q14669; Q14CA3; Q14CF1; Q15644; Q53R87; Q53TE7" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.070" "1.091" "1.112" "1.104" "1.022" "1.109" "1.034" "1.052" "1.055" "913.6" "977.4" "996.9" "1016.0" "1008.9" "933.3" "1013.0" "944.3" "961.3" "964.1" "" "" "" "" "" "" "" "" "" "" "733.8" "705.3" "791.8" "680.7" "697.7" "700.2" "709.2" "689.6" "961.3" "784.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591250137459754120" "False" "High" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "0.000" "False" "89.914" "31" "15" "23" "15" "624" "70.8" "6.86" "72.18" "15" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "Sulfation biotransformation reaction" "4" "0" "0.960" "1.010" "0.990" "0.990" "0.973" "0.943" "0.981" "1.000" "0.973" "1719.9" "1650.2" "1736.8" "1702.0" "1702.6" "1672.8" "1622.0" "1686.4" "1720.0" "1673.5" "" "" "" "" "" "" "" "" "" "" "1381.4" "1190.8" "1379.6" "1140.3" "1177.6" "1255.1" "1135.6" "1231.6" "1720.0" "1360.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9080862626962095597" "False" "High" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "0.000" "False" "89.905" "31" "12" "15" "12" "459" "50.9" "4.73" "63.68" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "0.973" "0.964" "0.973" "1.024" "0.972" "0.983" "0.916" "1.019" "0.996" "1268.2" "1234.2" "1222.3" "1233.9" "1298.0" "1232.4" "1246.7" "1161.8" "1292.7" "1262.8" "" "" "" "" "" "" "" "" "" "" "1018.6" "890.6" "970.9" "826.7" "897.7" "924.6" "872.8" "848.5" "1292.7" "1026.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926086327643907621" "False" "High" "IsMasterProtein" "Q6XZF7" "Dynamin-binding protein OS=Homo sapiens OX=9606 GN=DNMBP PE=1 SV=1" "0.000" "False" "89.877" "15" "20" "23" "20" "1577" "177.2" "5.39" "79.30" "20" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00018, Pf00621, Pf03114, Pf07653, Pf14604" "23268" "ENSG00000107554" "DNMBP" "hsa:23268; Q6XZF7; Q8IVY3; Q9Y2L3" "CDC42 GTPase cycle" "15q11q13 copy number variation" "2" "0" "1.058" "0.960" "1.017" "0.943" "0.953" "0.970" "0.997" "0.977" "1.036" "2444.8" "2587.6" "2347.0" "2486.3" "2306.7" "2329.5" "2371.8" "2438.6" "2389.5" "2533.8" "" "" "" "" "" "" "" "" "" "" "1963.7" "1867.2" "1864.3" "1665.8" "1595.3" "1747.8" "1660.6" "1780.9" "2389.5" "2060.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100436114582122401" "False" "High" "IsMasterProtein" "Q93034" "Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4" "0.000" "False" "89.823" "23" "17" "23" "17" "780" "90.9" "7.94" "86.29" "17" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf00888, Pf10557" "8065" "ENSG00000166266" "CUL5" "A8K960; O14766; Q93034; Q9BZC6" "Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Downregulation of ERBB2 signaling; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation; 10q11.21q11.23 copy number variation syndrome" "10" "0" "0.991" "1.006" "1.006" "0.972" "0.966" "0.988" "1.031" "1.006" "0.983" "2775.0" "2748.7" "2792.3" "2790.7" "2697.9" "2679.6" "2741.6" "2859.7" "2791.4" "2727.8" "" "" "" "" "" "" "" "" "" "" "2228.9" "1983.4" "2218.0" "1869.8" "1865.9" "2010.5" "1919.5" "2088.5" "2791.4" "2218.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2767928129327746769" "False" "High" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "0.000" "False" "89.762" "63" "10" "42" "10" "172" "19.8" "4.84" "137.69" "10" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13499" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "9" "0" "0.977" "1.026" "1.089" "1.075" "1.092" "1.094" "1.101" "1.015" "1.054" "2551.7" "2491.8" "2617.4" "2778.3" "2743.4" "2785.9" "2791.5" "2809.8" "2589.6" "2690.4" "" "" "" "" "" "" "" "" "" "" "2049.5" "1798.0" "2079.1" "1861.5" "1897.4" "2090.2" "1954.4" "2052.0" "2589.6" "2187.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762043181650020657" "False" "High" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "0.000" "False" "89.630" "53" "12" "24" "12" "303" "33.8" "6.74" "94.06" "12" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Frs2-mediated activation; Regulation of signaling by CBL; Downstream signal transduction; Erythropoietin activates RAS; MET activates RAP1 and RAC1; MET receptor recycling" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "22" "0" "0.966" "0.997" "0.975" "1.037" "0.981" "1.015" "1.050" "1.005" "1.019" "1426.8" "1377.9" "1422.4" "1391.2" "1479.7" "1400.0" "1448.4" "1498.7" "1434.2" "1453.8" "" "" "" "" "" "" "" "" "" "" "1146.0" "994.2" "1129.8" "932.1" "1023.4" "1050.4" "1014.1" "1094.5" "1434.2" "1182.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377635877244790923" "False" "High" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "0.000" "False" "89.515" "47" "12" "30" "3" "323" "37.0" "6.54" "101.42" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "17" "0" "0.890" "0.951" "0.912" "0.890" "0.860" "0.840" "0.821" "0.778" "0.860" "215.4" "191.7" "204.8" "196.5" "191.7" "185.3" "181.0" "176.8" "167.7" "185.3" "" "" "" "" "" "" "" "" "" "" "173.0" "138.4" "162.7" "131.7" "132.6" "139.0" "126.8" "129.1" "167.7" "150.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7075703887839209806" "False" "High" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "0.000" "False" "89.340" "22" "21" "27" "21" "972" "112.2" "6.64" "88.06" "21" "" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "1.002" "0.989" "0.995" "0.974" "0.997" "0.938" "0.943" "0.960" "0.995" "2878.3" "2884.7" "2847.5" "2864.9" "2804.8" "2868.7" "2699.6" "2715.1" "2764.4" "2865.2" "" "" "" "" "" "" "" "" "" "" "2311.8" "2081.5" "2261.9" "1919.5" "1939.8" "2152.3" "1890.1" "1982.9" "2764.4" "2330.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5455074280924099638" "False" "High" "IsMasterProtein" "Q15554" "Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3" "0.000" "False" "89.201" "20" "10" "13" "10" "542" "59.6" "9.35" "55.71" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf08558, Pf16772" "7014" "ENSG00000132604" "TERF2" "hsa:7014; Q15554" "Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; DNA repair pathways, full network; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "17" "0" "1.013" "1.017" "0.979" "1.019" "0.971" "1.056" "1.027" "1.038" "1.045" "1428.0" "1446.5" "1452.2" "1398.5" "1454.8" "1386.8" "1508.0" "1466.0" "1482.4" "1491.8" "" "" "" "" "" "" "" "" "" "" "1146.9" "1043.7" "1153.5" "937.0" "1006.1" "1040.5" "1055.8" "1070.6" "1482.4" "1213.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558081350695480590" "False" "High" "IsMasterProtein" "O43172" "U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2" "0.000" "False" "89.177" "32" "14" "24" "14" "522" "58.4" "7.42" "89.78" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08799" "9128" "ENSG00000136875" "PRPF4" "hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.069" "1.073" "1.034" "1.083" "1.045" "1.062" "1.125" "1.076" "1.098" "1477.3" "1579.0" "1585.0" "1528.1" "1600.3" "1544.3" "1569.5" "1662.4" "1589.5" "1622.2" "" "" "" "" "" "" "" "" "" "" "1186.5" "1139.3" "1259.0" "1023.8" "1106.8" "1158.6" "1098.9" "1214.1" "1589.5" "1319.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574312361860662093" "False" "High" "IsMasterProtein" "Q92620" "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2" "0.000" "False" "89.137" "15" "17" "23" "17" "1227" "140.4" "6.54" "64.15" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9785" "ENSG00000140829" "DHX38" "B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "5" "0" "1.018" "1.006" "1.014" "1.045" "1.000" "1.012" "1.042" "1.086" "1.014" "1202.2" "1224.1" "1209.1" "1219.6" "1256.8" "1201.7" "1216.0" "1252.2" "1305.1" "1218.6" "" "" "" "" "" "" "" "" "" "" "965.6" "883.3" "960.4" "817.1" "869.2" "901.6" "851.4" "914.5" "1305.1" "991.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7222850354556005820" "False" "High" "IsMasterProtein" "P20839" "Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2" "0.000" "False" "89.103" "29" "12" "26" "11" "514" "55.4" "6.90" "91.41" "12" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3614" "ENSG00000106348" "IMPDH1" "A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; hsa:3614; J3KNX8; P20839; Q8N194; Q96NU2" "Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "" "4" "0" "1.048" "1.005" "1.005" "1.013" "0.961" "0.970" "0.970" "0.932" "0.933" "2138.1" "2240.1" "2148.6" "2148.0" "2166.6" "2054.1" "2074.5" "2074.8" "1992.7" "1995.0" "" "" "" "" "" "" "" "" "" "" "1717.3" "1616.4" "1706.7" "1439.2" "1498.4" "1541.1" "1452.4" "1515.2" "1992.7" "1622.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656717572997732758" "False" "High" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "0.000" "False" "89.095" "27" "12" "25" "12" "484" "54.9" "7.11" "96.42" "12" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "1.036" "1.042" "0.983" "1.016" "1.019" "0.946" "0.969" "1.018" "1.018" "2424.1" "2510.9" "2527.0" "2383.5" "2463.5" "2470.5" "2293.2" "2348.1" "2469.0" "2468.1" "" "" "" "" "" "" "" "" "" "" "1947.0" "1811.8" "2007.3" "1596.9" "1703.8" "1853.6" "1605.6" "1714.8" "2469.0" "2007.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3066040936717898467" "False" "High" "IsMasterProtein" "Q8NC60" "Nitric oxide-associated protein 1 OS=Homo sapiens OX=9606 GN=NOA1 PE=1 SV=2" "0.000" "False" "89.031" "21" "12" "17" "12" "698" "78.4" "8.66" "66.72" "12" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf01926, Pf21516" "84273" "ENSG00000084092" "NOA1" "hsa:84273; Q8N7L6; Q8NC60; Q9BSQ9" "" "" "0" "0" "1.068" "1.018" "1.020" "1.065" "1.026" "0.970" "1.098" "1.047" "1.065" "1337.6" "1427.9" "1361.7" "1364.2" "1424.5" "1372.4" "1297.3" "1468.8" "1401.0" "1424.7" "" "" "" "" "" "" "" "" "" "" "1074.3" "1030.4" "1081.6" "914.0" "985.2" "1029.7" "908.3" "1072.6" "1401.0" "1158.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1716870644817082742" "False" "High" "IsMasterProtein" "Q15751" "Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2" "0.000" "False" "89.007" "5" "22" "26" "22" "4861" "531.9" "6.04" "72.47" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00415, Pf00622, Pf00632" "8925" "ENSG00000103657" "HERC1" "hsa:8925; Q15751; Q8IW65" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.998" "0.901" "1.019" "0.989" "0.983" "0.988" "0.964" "0.961" "0.986" "825.9" "823.9" "744.2" "841.9" "816.9" "812.0" "816.2" "796.1" "793.9" "814.5" "" "" "" "" "" "" "" "" "" "" "663.4" "594.5" "591.1" "564.1" "565.0" "609.2" "571.4" "581.4" "793.9" "662.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4143955501491186019" "False" "High" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "0.000" "False" "88.985" "34" "14" "28" "14" "474" "51.3" "9.41" "90.38" "14" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "1.021" "1.016" "0.923" "0.924" "1.008" "0.920" "0.984" "1.019" "0.957" "2841.3" "2899.9" "2885.6" "2621.9" "2624.3" "2863.6" "2613.1" "2796.1" "2896.1" "2718.2" "" "" "" "" "" "" "" "" "" "" "2282.1" "2092.5" "2292.1" "1756.7" "1815.0" "2148.5" "1829.5" "2042.0" "2896.1" "2210.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013273140133158732" "False" "High" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "0.000" "False" "88.980" "29" "12" "20" "12" "528" "60.6" "5.06" "76.20" "12" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "0.935" "0.931" "0.981" "1.014" "0.946" "0.993" "0.978" "0.987" "0.946" "665.7" "622.1" "620.0" "653.4" "675.4" "630.0" "661.3" "651.0" "657.0" "630.1" "" "" "" "" "" "" "" "" "" "" "534.7" "448.9" "492.5" "437.8" "467.1" "472.7" "463.0" "475.5" "657.0" "512.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667364436417788912" "False" "High" "IsMasterProtein" "Q9BYV8" "Centrosomal protein of 41 kDa OS=Homo sapiens OX=9606 GN=CEP41 PE=1 SV=1" "0.000" "False" "88.860" "37" "9" "12" "9" "373" "41.3" "8.32" "48.51" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;cytoskeleton;other cell component" "" "Pf00581" "95681" "ENSG00000106477" "CEP41" "A4D1M0; B4DQ35; F5H0V6; hsa:95681; Q7Z496; Q86TM1; Q8NFU8; Q9BYV8; Q9H6A3; Q9NPV3" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "10" "0" "1.012" "1.006" "1.020" "0.995" "0.988" "0.973" "0.925" "1.022" "1.039" "691.5" "699.7" "695.5" "705.5" "688.1" "683.2" "672.7" "639.5" "706.9" "718.4" "" "" "" "" "" "" "" "" "" "" "555.4" "504.9" "552.5" "472.7" "475.9" "512.6" "471.0" "467.0" "706.9" "584.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5974155710491899055" "False" "High" "IsMasterProtein" "Q9UHD2" "Serine/threonine-protein kinase TBK1 OS=Homo sapiens OX=9606 GN=TBK1 PE=1 SV=1" "0.000" "False" "88.860" "25" "14" "18" "14" "729" "83.6" "6.79" "70.16" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf18394, Pf18396" "29110" "ENSG00000183735" "TBK1" "A8K4S4; hsa:29110; Q8IYV3; Q9NUJ5; Q9UHD2" "Negative regulators of DDX58/IFIH1 signaling; IRF3-mediated induction of type I IFN; Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Regulation of TNFR1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TNFR1-induced proapoptotic signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Interleukin-37 signaling; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN" "TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Toll-like receptor signaling pathway" "35" "0" "1.033" "0.998" "0.929" "0.938" "0.964" "0.912" "0.987" "1.015" "1.003" "999.0" "1032.5" "997.5" "928.1" "936.8" "963.0" "911.4" "986.0" "1014.4" "1001.7" "" "" "" "" "" "" "" "" "" "" "802.4" "745.0" "792.4" "621.8" "647.9" "722.5" "638.1" "720.1" "1014.4" "814.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200179838073860903" "False" "High" "IsMasterProtein" "O76031" "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" "0.000" "False" "88.697" "23" "14" "25" "14" "633" "69.2" "7.58" "94.19" "14" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07724, Pf10431" "10845" "ENSG00000166855" "CLPX" "A1L428; A8K8F1; B9EGI8; hsa:10845; O76031; Q9H4D9" "Mitochondrial protein degradation" "" "1" "0" "0.989" "1.010" "0.942" "0.998" "0.987" "0.918" "1.012" "0.968" "0.987" "2539.6" "2511.9" "2564.3" "2392.9" "2533.4" "2507.8" "2331.6" "2569.3" "2459.3" "2505.7" "" "" "" "" "" "" "" "" "" "" "2039.8" "1812.5" "2036.9" "1603.2" "1752.1" "1881.5" "1632.5" "1876.4" "2459.3" "2037.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135385361793162553" "False" "High" "IsMasterProtein" "Q9BQA1" "Methylosome protein WDR77 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "0.000" "False" "88.674" "38" "8" "18" "8" "342" "36.7" "5.17" "77.15" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "RMTs methylate histone arginines; snRNP Assembly" "" "2" "0" "1.113" "1.067" "1.178" "1.085" "1.081" "1.060" "1.021" "1.007" "1.048" "824.8" "917.6" "879.9" "971.7" "894.8" "892.0" "874.5" "842.4" "830.5" "864.7" "" "" "" "" "" "" "" "" "" "" "662.5" "662.1" "698.9" "651.0" "618.9" "669.2" "612.3" "615.2" "830.5" "703.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2386724705728610253" "False" "High" "IsMasterProtein" "Q9UHB6" "LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1" "0.000" "False" "88.641" "25" "17" "23" "17" "759" "85.2" "6.84" "78.14" "17" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "51474" "ENSG00000050405" "LIMA1" "B2RB09; hsa:51474; Q2TAN7; Q59FE8; Q9BVF2; Q9H8J1; Q9HBN5; Q9NX96; Q9NXC3; Q9NXU6; Q9P0H8; Q9UHB5; Q9UHB6" "" "" "0" "0" "0.903" "1.033" "0.985" "0.864" "1.042" "1.052" "0.995" "0.972" "1.008" "1687.2" "1523.1" "1743.1" "1661.4" "1457.6" "1758.2" "1775.3" "1678.3" "1639.3" "1701.1" "" "" "" "" "" "" "" "" "" "" "1355.1" "1099.0" "1384.6" "1113.2" "1008.1" "1319.2" "1243.0" "1225.7" "1639.3" "1383.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773020118127395212" "False" "High" "IsMasterProtein" "P30740" "Leukocyte elastase inhibitor OS=Homo sapiens OX=9606 GN=SERPINB1 PE=1 SV=1" "0.000" "False" "88.530" "38" "15" "28" "14" "379" "42.7" "6.28" "94.00" "15" "cell cycle OR cell proliferation;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00079" "1992" "ENSG00000021355" "SERPINB1" "A8K5L2; B4DNT0; hsa:1992; P30740; Q53FB9; Q5W0E1; Q9UDF8" "Neutrophil degranulation" "Vitamin D receptor pathway" "2" "0" "1.033" "0.994" "1.022" "1.005" "0.994" "1.030" "0.972" "1.024" "0.994" "1876.4" "1938.6" "1864.2" "1916.9" "1885.2" "1866.0" "1933.3" "1823.8" "1921.6" "1865.6" "" "" "" "" "" "" "" "" "" "" "1507.1" "1398.8" "1480.8" "1284.3" "1303.9" "1400.0" "1353.6" "1331.9" "1921.6" "1517.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1817111684576735415" "False" "High" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "0.000" "False" "88.486" "66" "8" "24" "8" "151" "16.3" "5.67" "106.84" "8" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "8" "0" "1.104" "1.122" "1.086" "1.031" "1.057" "1.046" "1.047" "1.013" "1.033" "2044.5" "2257.0" "2294.5" "2220.6" "2108.7" "2162.1" "2138.9" "2139.8" "2071.1" "2111.9" "" "" "" "" "" "" "" "" "" "" "1642.1" "1628.6" "1822.6" "1487.8" "1458.4" "1622.2" "1497.5" "1562.7" "2071.1" "1717.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557682221437211922" "False" "High" "IsMasterProtein" "Q9Y6Q9" "Nuclear receptor coactivator 3 OS=Homo sapiens OX=9606 GN=NCOA3 PE=1 SV=1" "0.000" "False" "88.485" "12" "14" "17" "14" "1424" "155.2" "7.47" "65.19" "14" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16279, Pf16665" "8202" "ENSG00000124151" "NCOA3" "A4LAZ5; hsa:8202; Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; Q9Y6Q9" "Estrogen-dependent gene expression; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; MAPK6/MAPK4 signaling" "Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway; Rubinstein-Taybi syndrome 1" "11" "0" "1.021" "0.963" "0.957" "0.941" "0.916" "0.855" "0.915" "0.922" "0.976" "1955.2" "1995.9" "1883.5" "1870.6" "1839.8" "1790.2" "1671.7" "1788.2" "1802.3" "1909.1" "" "" "" "" "" "" "" "" "" "" "1570.4" "1440.2" "1496.1" "1253.3" "1272.4" "1343.2" "1170.4" "1306.0" "1802.3" "1552.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8648350258145669710" "False" "High" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "0.000" "False" "88.474" "50" "13" "32" "13" "326" "36.1" "9.17" "104.80" "13" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "HuR (ELAVL1) binds and stabilizes mRNA" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "10" "0" "1.035" "1.053" "1.082" "1.136" "1.055" "1.074" "1.109" "1.048" "1.023" "1371.4" "1419.8" "1444.3" "1484.4" "1557.3" "1447.1" "1473.2" "1520.4" "1436.5" "1402.9" "" "" "" "" "" "" "" "" "" "" "1101.5" "1024.5" "1147.3" "994.5" "1077.1" "1085.7" "1031.4" "1110.3" "1436.5" "1140.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990547013884615551" "False" "High" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "0.000" "False" "88.458" "18" "13" "17" "13" "913" "101.3" "5.45" "71.21" "13" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "" "Ectoderm differentiation" "1" "0" "1.002" "0.975" "0.994" "1.013" "1.030" "0.993" "0.979" "1.024" "1.021" "1925.1" "1928.3" "1877.3" "1914.0" "1949.3" "1982.8" "1911.5" "1884.4" "1972.0" "1966.1" "" "" "" "" "" "" "" "" "" "" "1546.2" "1391.4" "1491.2" "1282.4" "1348.2" "1487.6" "1338.3" "1376.2" "1972.0" "1598.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595519607435168922" "False" "High" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "0.000" "False" "88.413" "39" "9" "25" "8" "346" "36.9" "6.87" "81.69" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "1.016" "1.137" "1.088" "1.157" "1.172" "1.156" "1.159" "1.184" "1.094" "1113.3" "1130.7" "1266.1" "1210.9" "1288.1" "1304.3" "1286.8" "1289.8" "1318.6" "1218.1" "" "" "" "" "" "" "" "" "" "" "894.2" "815.9" "1005.7" "811.3" "890.9" "978.6" "900.9" "941.9" "1318.6" "990.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6456635449604072928" "False" "High" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "0.000" "False" "88.382" "31" "12" "32" "12" "496" "56.8" "7.80" "93.70" "12" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "" "3" "0" "0.981" "0.976" "0.973" "0.939" "0.935" "0.969" "0.971" "0.966" "0.985" "2414.5" "2369.5" "2355.4" "2350.3" "2268.4" "2258.8" "2339.8" "2345.1" "2333.2" "2378.6" "" "" "" "" "" "" "" "" "" "" "1939.3" "1709.8" "1871.0" "1574.7" "1568.9" "1694.7" "1638.2" "1712.6" "2333.2" "1934.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2163956888383823018" "False" "High" "IsMasterProtein" "Q96A65" "Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1" "0.000" "False" "88.244" "17" "13" "17" "13" "974" "110.4" "6.49" "68.56" "13" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04048, Pf20652" "60412" "ENSG00000131558" "EXOC4" "E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "1.016" "0.957" "1.036" "1.008" "0.971" "1.019" "1.036" "1.036" "1.008" "1634.0" "1659.3" "1563.0" "1692.2" "1647.4" "1586.8" "1664.5" "1692.3" "1693.3" "1646.8" "" "" "" "" "" "" "" "" "" "" "1312.4" "1197.3" "1241.5" "1133.8" "1139.3" "1190.5" "1165.4" "1235.9" "1693.3" "1339.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469246297971201094" "False" "High" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "0.000" "False" "88.094" "27" "15" "24" "15" "594" "67.2" "5.96" "87.10" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "1.028" "1.063" "1.098" "1.053" "1.077" "1.091" "1.099" "1.115" "1.076" "1807.8" "1858.5" "1921.4" "1985.1" "1904.4" "1946.5" "1971.5" "1987.3" "2015.2" "1944.7" "" "" "" "" "" "" "" "" "" "" "1452.0" "1341.0" "1526.2" "1330.0" "1317.1" "1460.5" "1380.4" "1451.3" "2015.2" "1581.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8097806180956091720" "False" "High" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "0.000" "False" "87.995" "31" "10" "28" "6" "425" "47.8" "5.05" "105.16" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "HCMV Early Events; Neddylation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in progeria" "20" "0" "1.046" "1.039" "0.992" "0.980" "1.006" "0.996" "0.992" "1.039" "1.021" "2642.7" "2764.9" "2746.3" "2622.7" "2589.0" "2657.9" "2632.2" "2621.0" "2745.1" "2697.2" "" "" "" "" "" "" "" "" "" "" "2122.6" "1995.1" "2181.5" "1757.2" "1790.5" "1994.2" "1842.9" "1914.1" "2745.1" "2193.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7242737941757580841" "False" "High" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "0.000" "False" "87.926" "41" "6" "21" "6" "237" "26.2" "4.11" "79.01" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "snRNP Assembly" "" "1" "0" "1.066" "1.046" "1.010" "1.037" "1.061" "0.924" "1.032" "1.072" "1.037" "655.0" "697.9" "685.2" "661.4" "678.9" "694.7" "604.9" "675.7" "702.2" "679.3" "" "" "" "" "" "" "" "" "" "" "526.1" "503.6" "544.3" "443.2" "469.5" "521.2" "423.5" "493.4" "702.2" "552.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5118939103406682552" "False" "High" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "0.000" "False" "87.917" "18" "17" "25" "17" "1081" "118.6" "4.96" "86.54" "17" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "1.067" "1.035" "1.054" "1.070" "0.992" "0.992" "0.993" "1.035" "1.001" "1045.2" "1115.5" "1082.0" "1102.0" "1118.4" "1036.6" "1037.1" "1037.7" "1081.5" "1046.1" "" "" "" "" "" "" "" "" "" "" "839.5" "804.9" "859.5" "738.4" "773.5" "777.8" "726.1" "757.8" "1081.5" "850.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144815558027084880" "False" "High" "IsMasterProtein" "Q96FV9" "THO complex subunit 1 OS=Homo sapiens OX=9606 GN=THOC1 PE=1 SV=1" "0.000" "False" "87.840" "32" "18" "28" "18" "657" "75.6" "4.98" "76.01" "18" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00531, Pf11957" "9984" "ENSG00000079134" "THOC1" "B2RBP6; hsa:9984; Q15219; Q64I72; Q64I73; Q96FV9" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.029" "1.034" "1.013" "1.042" "1.036" "1.032" "1.023" "1.049" "1.034" "2264.2" "2330.7" "2340.8" "2294.5" "2358.3" "2345.5" "2337.1" "2316.7" "2374.8" "2341.5" "" "" "" "" "" "" "" "" "" "" "1818.6" "1681.8" "1859.4" "1537.3" "1631.0" "1759.8" "1636.3" "1691.9" "2374.8" "1904.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "240711896831941506" "False" "High" "IsMasterProtein" "P23396" "Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "0.000" "False" "87.832" "57" "13" "33" "13" "243" "26.7" "9.66" "111.18" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.962" "1.211" "1.096" "1.161" "1.127" "1.236" "1.149" "1.096" "1.115" "2254.9" "2168.8" "2731.6" "2471.5" "2617.0" "2540.8" "2786.1" "2591.2" "2472.2" "2513.2" "" "" "" "" "" "" "" "" "" "" "1811.1" "1565.0" "2169.8" "1655.9" "1810.0" "1906.3" "1950.7" "1892.3" "2472.2" "2043.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135985212415519925" "False" "High" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "0.000" "False" "87.822" "42" "20" "32" "20" "418" "47.3" "5.21" "114.35" "20" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Assembly of the pre-replicative complex; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "64" "0" "0.973" "0.959" "0.937" "0.954" "0.937" "0.972" "0.965" "0.993" "0.935" "2949.0" "2870.2" "2829.6" "2764.0" "2812.3" "2762.9" "2865.4" "2846.1" "2929.4" "2757.5" "" "" "" "" "" "" "" "" "" "" "2368.6" "2071.1" "2247.6" "1851.9" "1945.0" "2073.0" "2006.2" "2078.5" "2929.4" "2242.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320605404870657198" "False" "High" "IsMasterProtein" "Q8NC51" "SERPINE1 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "0.000" "False" "87.782" "40" "15" "24" "15" "408" "44.9" "8.65" "75.96" "15" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "1" "0" "0.970" "1.152" "1.202" "1.268" "1.349" "1.388" "1.216" "1.200" "1.171" "1569.6" "1522.6" "1808.2" "1887.2" "1990.7" "2117.9" "2178.6" "1907.9" "1883.4" "1837.9" "" "" "" "" "" "" "" "" "" "" "1260.7" "1098.7" "1436.3" "1264.4" "1376.8" "1589.0" "1525.4" "1393.3" "1883.4" "1494.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3281625266906913156" "False" "High" "IsMasterProtein" "Q7RTP6" "[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2" "0.000" "False" "87.765" "11" "19" "20" "19" "2002" "224.2" "5.55" "65.11" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "57553" "ENSG00000243156" "MICAL3" "B2RXJ5; E9PEF0; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3" "" "" "0" "0" "1.039" "0.976" "0.996" "1.026" "0.980" "0.981" "1.030" "0.997" "1.015" "1169.7" "1214.8" "1141.8" "1164.9" "1200.2" "1146.0" "1147.8" "1204.7" "1166.6" "1187.0" "" "" "" "" "" "" "" "" "" "" "939.5" "876.6" "906.9" "780.5" "830.1" "859.8" "803.6" "879.8" "1166.6" "965.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5761790178817742854" "False" "High" "IsMasterProtein" "Q96P70" "Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3" "0.000" "False" "87.728" "20" "18" "25" "18" "1041" "115.9" "4.81" "80.68" "18" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03810" "55705" "ENSG00000198700" "IPO9" "B1ASV5; hsa:55705; Q8N1Y1; Q8N3I2; Q8NCG9; Q96P70; Q96SU6; Q9NW01; Q9P0A8; Q9ULM8" "" "" "0" "0" "0.982" "0.970" "0.984" "0.971" "0.947" "0.936" "1.012" "0.956" "0.962" "1984.8" "1949.7" "1925.9" "1953.7" "1926.5" "1880.4" "1858.1" "2009.3" "1896.7" "1908.8" "" "" "" "" "" "" "" "" "" "" "1594.2" "1406.8" "1529.8" "1309.0" "1332.4" "1410.9" "1300.9" "1467.4" "1896.7" "1552.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6056381579766233841" "False" "High" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "0.000" "False" "87.716" "39" "16" "32" "15" "406" "46.6" "6.16" "93.50" "16" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "1" "1.002" "1.003" "0.996" "0.988" "0.954" "0.974" "1.031" "1.015" "0.972" "2974.4" "2979.6" "2984.8" "2961.7" "2938.3" "2836.8" "2897.1" "3066.7" "3019.3" "2891.1" "" "" "" "" "" "" "" "" "" "" "2389.0" "2150.0" "2370.9" "1984.3" "2032.1" "2128.4" "2028.4" "2239.6" "3019.3" "2351.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "854871700707894946" "False" "High" "IsMasterProtein" "Q9NZL4" "Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2" "0.000" "False" "87.652" "53" "14" "25" "14" "359" "39.3" "5.21" "86.92" "14" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf08609" "23640" "ENSG00000133265" "HSPBP1" "B3KQP0; B4DG11; hsa:23640; O95351; Q6ZNU5; Q9NZL4" "" "" "0" "0" "1.038" "1.030" "1.059" "1.041" "1.012" "0.960" "1.003" "1.008" "1.051" "937.5" "973.3" "965.3" "993.2" "976.2" "948.3" "900.1" "940.6" "945.2" "985.4" "" "" "" "" "" "" "" "" "" "" "753.0" "702.3" "766.8" "665.4" "675.1" "711.5" "630.2" "686.9" "945.2" "801.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-453379581051164535" "False" "High" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "0.000" "False" "87.571" "51" "8" "44" "8" "187" "21.0" "7.53" "171.22" "8" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "9" "0" "1.013" "1.032" "0.988" "0.992" "1.024" "1.023" "1.025" "1.004" "0.991" "4382.3" "4441.3" "4522.8" "4331.1" "4349.2" "4485.7" "4485.0" "4490.1" "4399.5" "4343.1" "" "" "" "" "" "" "" "" "" "" "3519.8" "3204.7" "3592.6" "2901.9" "3007.9" "3365.5" "3140.2" "3279.2" "4399.5" "3532.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3957617844882623254" "False" "High" "IsMasterProtein" "Q7Z3B4" "Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2" "0.000" "False" "87.545" "36" "15" "23" "15" "507" "55.4" "7.02" "76.92" "15" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13874, Pf18437" "53371" "ENSG00000138750" "NUP54" "B2RCK7; B4DT35; hsa:53371; Q7Z3B4; Q96EA7; Q9NVL5; Q9P0I1" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "1.017" "0.953" "1.076" "1.102" "1.027" "0.970" "1.039" "1.058" "1.052" "728.6" "741.1" "694.5" "784.1" "803.0" "748.5" "706.7" "757.1" "770.9" "766.7" "" "" "" "" "" "" "" "" "" "" "585.2" "534.7" "551.6" "525.3" "555.4" "561.6" "494.8" "552.9" "770.9" "623.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-320392191251803943" "False" "High" "IsMasterProtein" "Q9BXS6" "Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1" "0.000" "False" "87.524" "37" "14" "25" "14" "441" "49.4" "9.91" "89.97" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf16006" "51203" "ENSG00000137804" "NUSAP1" "B4DDF1; E7ERR5; hsa:51203; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9BXS6; Q9GZM9; Q9NZ85; Q9UI70" "" "" "0" "0" "0.975" "1.023" "0.964" "0.989" "0.968" "0.603" "0.634" "0.641" "0.886" "2358.0" "2298.8" "2411.9" "2273.7" "2331.7" "2283.4" "1422.0" "1494.9" "1512.6" "2089.5" "" "" "" "" "" "" "" "" "" "" "1893.9" "1658.7" "1915.9" "1523.4" "1612.6" "1713.2" "995.6" "1091.8" "1512.6" "1699.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6712994512663593747" "False" "High" "IsMasterProtein" "Q4G0N4" "NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2" "0.000" "False" "87.342" "36" "16" "20" "16" "442" "49.4" "8.18" "69.93" "16" "other metabolic processes" "mitochondrion" "kinase activity;other molecular function" "Pf01513" "133686" "ENSG00000152620" "NADK2" "B5MC93; hsa:133686; Q4G0N4; Q6UTX5; Q96NM0" "Mitochondrial protein degradation; Nicotinate metabolism" "" "2" "0" "1.019" "0.994" "1.002" "0.956" "0.951" "0.909" "0.919" "0.920" "0.946" "1585.7" "1616.3" "1576.8" "1588.4" "1515.3" "1507.4" "1440.8" "1457.1" "1459.4" "1500.3" "" "" "" "" "" "" "" "" "" "" "1273.6" "1166.3" "1252.5" "1064.2" "1048.0" "1130.9" "1008.7" "1064.1" "1459.4" "1220.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8858852225098701208" "False" "High" "IsMasterProtein" "P49642" "DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1" "0.000" "False" "87.288" "40" "16" "22" "16" "420" "49.9" "8.21" "65.84" "16" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01896" "5557" "ENSG00000198056" "PRIM1" "hsa:5557; P49642" "Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "13" "0" "1.006" "1.013" "1.012" "0.961" "1.043" "0.889" "1.000" "0.928" "1.008" "1507.7" "1516.4" "1527.9" "1525.8" "1448.5" "1572.8" "1340.5" "1507.7" "1399.9" "1519.1" "" "" "" "" "" "" "" "" "" "" "1211.0" "1094.2" "1213.6" "1022.3" "1001.8" "1180.0" "938.5" "1101.1" "1399.9" "1235.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2616426161905977358" "False" "High" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "0.000" "False" "87.272" "26" "16" "36" "16" "623" "71.2" "7.37" "104.57" "16" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "NFE2L2 regulating MDR associated enzymes" "VEGFA-VEGFR2 signaling" "2" "0" "0.988" "1.018" "1.022" "1.022" "1.044" "1.078" "1.034" "1.063" "1.013" "2725.4" "2693.3" "2773.1" "2784.8" "2784.8" "2846.0" "2936.9" "2817.0" "2896.0" "2761.3" "" "" "" "" "" "" "" "" "" "" "2189.0" "1943.4" "2202.8" "1865.8" "1926.0" "2135.3" "2056.2" "2057.2" "2896.0" "2245.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3818146926309850822" "False" "High" "IsMasterProtein" "O95671" "Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3" "0.000" "False" "87.255" "30" "16" "21" "16" "621" "68.8" "6.07" "73.43" "16" "other metabolic processes" "cytosol" "other molecular function" "Pf00891, Pf02545, Pf16864" "8623" "ENSG00000169093; ENSG00000292339" "ASMTL" "B4DX75; F5GXH4; hsa:8623; J3JS33; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6" "" "" "0" "0" "1.028" "0.980" "1.037" "1.012" "1.014" "1.003" "0.983" "1.039" "0.977" "845.5" "869.3" "828.3" "876.5" "855.7" "857.4" "847.7" "831.3" "878.9" "826.5" "" "" "" "" "" "" "" "" "" "" "679.1" "627.2" "657.9" "587.3" "591.8" "643.3" "593.5" "607.1" "878.9" "672.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147874032451066507" "False" "High" "IsMasterProtein" "Q15036" "Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1" "0.000" "False" "87.232" "34" "12" "16" "12" "470" "52.9" "7.46" "62.21" "12" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf18116, Pf21271, Pf21273" "9784" "ENSG00000115234" "SNX17" "B4DQM7; hsa:9784; Q15036; Q53HN7; Q6IAS3" "" "" "0" "0" "1.052" "1.000" "1.097" "1.058" "1.026" "0.967" "0.962" "0.977" "1.043" "860.5" "904.9" "860.9" "944.3" "910.3" "882.5" "831.7" "828.1" "840.7" "897.3" "" "" "" "" "" "" "" "" "" "" "691.2" "652.9" "683.8" "632.6" "629.6" "662.2" "582.3" "604.7" "840.7" "729.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7512060777885112035" "False" "High" "IsMasterProtein" "P63244" "Small ribosomal subunit protein RACK1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "0.000" "False" "87.124" "50" "14" "19" "14" "317" "35.1" "7.69" "75.07" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "10" "0" "0.865" "1.041" "1.018" "1.083" "1.078" "1.212" "0.982" "0.995" "0.996" "2247.3" "1943.7" "2339.7" "2287.6" "2432.9" "2423.2" "2723.4" "2205.8" "2237.1" "2238.0" "" "" "" "" "" "" "" "" "" "" "1805.0" "1402.5" "1858.5" "1532.7" "1682.6" "1818.0" "1906.7" "1610.9" "2237.1" "1820.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4457401366019025404" "False" "High" "IsMasterProtein" "Q7KZI7" "Serine/threonine-protein kinase MARK2 OS=Homo sapiens OX=9606 GN=MARK2 PE=1 SV=2" "0.000" "False" "87.031" "26" "17" "23" "15" "788" "87.9" "9.72" "79.53" "17" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "2011" "ENSG00000072518" "MARK2" "hsa:2011; Q15449; Q15524; Q5XGA3; Q68A18; Q7KZI7; Q96HB3; Q96RG0" "" "Microtubule cytoskeleton regulation; Complement system in neuronal development and plasticity; Neurogenesis regulation in the olfactory epithelium" "3" "1" "1.008" "1.055" "1.109" "1.065" "1.044" "1.086" "1.060" "1.102" "1.088" "1848.0" "1862.7" "1948.8" "2049.7" "1968.3" "1929.6" "2007.0" "1958.5" "2037.3" "2009.7" "" "" "" "" "" "" "" "" "" "" "1484.3" "1344.1" "1548.0" "1373.3" "1361.3" "1447.8" "1405.2" "1430.3" "2037.3" "1634.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2652497111054879184" "False" "High" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "0.000" "False" "87.027" "34" "12" "18" "12" "468" "54.4" "5.68" "73.23" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "Detoxification of Reactive Oxygen Species" "" "1" "0" "1.020" "0.975" "1.010" "1.012" "0.974" "0.985" "1.020" "0.975" "0.984" "1975.4" "2014.2" "1925.5" "1995.2" "1999.3" "1923.2" "1944.9" "2015.7" "1925.4" "1943.2" "" "" "" "" "" "" "" "" "" "" "1586.6" "1453.4" "1529.5" "1336.8" "1382.7" "1442.9" "1361.7" "1472.1" "1925.4" "1580.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813014236257881133" "False" "High" "IsMasterProtein" "P21291" "Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3" "0.000" "False" "86.973" "64" "10" "29" "10" "193" "20.6" "8.57" "103.34" "10" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1465" "ENSG00000159176" "CSRP1" "A8K268; hsa:1465; P21291; Q5U0J2" "MTF1 activates gene expression" "MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling" "3" "0" "0.980" "0.998" "0.880" "0.918" "1.026" "0.972" "0.979" "1.019" "0.964" "3010.8" "2950.2" "3006.1" "2648.6" "2764.7" "3088.5" "2925.0" "2948.7" "3068.7" "2901.3" "" "" "" "" "" "" "" "" "" "" "2418.3" "2128.8" "2387.8" "1774.6" "1912.1" "2317.3" "2047.9" "2153.5" "3068.7" "2359.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-564768690041684779" "False" "High" "IsMasterProtein" "Q9H0L4" "Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1" "0.000" "False" "86.839" "32" "15" "20" "8" "616" "64.4" "7.25" "64.75" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "23283" "ENSG00000177613" "CSTF2T" "B2RAR9; hsa:23283; O75174; Q53HK6; Q7LGE8; Q8N6T1; Q9H0L4" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "7" "0.979" "0.976" "1.046" "1.040" "1.022" "1.081" "1.054" "1.039" "1.016" "988.4" "967.8" "964.6" "1034.0" "1027.6" "1010.3" "1068.3" "1042.1" "1027.3" "1004.1" "" "" "" "" "" "" "" "" "" "" "793.9" "698.3" "766.2" "692.8" "710.7" "758.0" "748.0" "761.1" "1027.3" "816.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832303337719112949" "False" "High" "IsMasterProtein" "Q15154" "Pericentriolar material 1 protein OS=Homo sapiens OX=9606 GN=PCM1 PE=1 SV=6" "0.000" "False" "86.798" "11" "18" "23" "17" "2024" "228.4" "5.02" "85.34" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15717" "5108" "ENSG00000078674" "PCM1" "A6NNN6; B4DYD5; E7ETA6; E7EV56; hsa:5108; Q15154; Q58F13; Q6P1K7; Q8NB85; Q9BWC1; Q9H4A2" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Prader-Willi and Angelman syndrome; Joubert syndrome" "9" "0" "1.046" "1.074" "1.128" "1.073" "1.117" "1.172" "1.120" "1.058" "1.081" "792.5" "829.2" "851.4" "894.1" "850.4" "885.5" "928.9" "887.4" "838.5" "857.0" "" "" "" "" "" "" "" "" "" "" "636.6" "598.3" "676.3" "599.1" "588.1" "664.3" "650.4" "648.1" "838.5" "696.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985233522455606046" "False" "High" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "0.000" "False" "86.778" "53" "10" "29" "10" "197" "22.6" "7.11" "105.46" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.035" "1.041" "1.019" "0.944" "1.114" "1.025" "1.007" "1.007" "1.034" "4127.6" "4270.1" "4298.0" "4204.5" "3896.5" "4596.8" "4231.5" "4155.2" "4154.5" "4269.5" "" "" "" "" "" "" "" "" "" "" "3315.3" "3081.2" "3414.0" "2817.0" "2694.8" "3448.9" "2962.7" "3034.6" "4154.5" "3472.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485182549121438413" "False" "High" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "0.000" "False" "86.738" "21" "22" "34" "22" "1098" "123.8" "8.65" "100.66" "22" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "mRNA Splicing - Major Pathway" "" "1" "0" "1.008" "0.988" "0.994" "0.984" "0.970" "0.943" "0.963" "0.963" "0.990" "3450.1" "3477.6" "3409.6" "3429.6" "3393.6" "3345.0" "3254.7" "3323.7" "3320.9" "3416.4" "" "" "" "" "" "" "" "" "" "" "2771.1" "2509.3" "2708.3" "2297.8" "2347.0" "2509.7" "2278.8" "2427.3" "3320.9" "2778.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003283534467846840" "False" "High" "IsMasterProtein" "P40937" "Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1" "0.000" "False" "86.688" "48" "15" "28" "15" "340" "38.5" "7.20" "81.34" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5985" "ENSG00000111445" "RFC5" "A8MZ62; B3KSX8; hsa:5985; P40937" "HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "1.069" "1.044" "1.110" "1.064" "0.986" "1.093" "1.170" "1.049" "1.072" "1997.4" "2135.2" "2084.8" "2216.3" "2125.7" "1970.4" "2183.2" "2337.3" "2094.4" "2142.2" "" "" "" "" "" "" "" "" "" "" "1604.3" "1540.7" "1656.0" "1484.9" "1470.2" "1478.4" "1528.5" "1706.9" "2094.4" "1742.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5200719085873833637" "False" "High" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "0.000" "False" "86.577" "30" "12" "21" "12" "434" "48.3" "7.93" "76.31" "12" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialic acid metabolism" "Sialylation" "2" "0" "1.063" "1.055" "0.989" "0.973" "1.011" "0.991" "1.011" "1.004" "1.015" "2232.5" "2373.5" "2355.3" "2207.7" "2171.3" "2257.5" "2211.7" "2256.1" "2241.4" "2265.9" "" "" "" "" "" "" "" "" "" "" "1793.1" "1712.6" "1870.9" "1479.1" "1501.7" "1693.8" "1548.5" "1647.7" "2241.4" "1842.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6470269132294442760" "False" "High" "IsMasterProtein" "Q8WUM0" "Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2" "0.000" "False" "86.573" "18" "15" "20" "15" "1156" "128.9" "5.10" "68.55" "15" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03177" "55746" "ENSG00000069248" "NUP133" "B2RAZ8; hsa:55746; Q5T8N0; Q8WUM0; Q9H9W2; Q9NV71; Q9NVC4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of HSF1-mediated heat shock response; snRNP Assembly; HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "Ciliary landscape" "36" "0" "1.020" "1.032" "1.033" "1.049" "0.989" "1.013" "1.168" "1.078" "1.056" "1034.9" "1055.6" "1068.0" "1068.6" "1085.3" "1023.8" "1048.5" "1209.0" "1115.5" "1092.6" "" "" "" "" "" "" "" "" "" "" "831.2" "761.7" "848.3" "716.0" "750.6" "768.1" "734.1" "882.9" "1115.5" "888.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5390020710088679993" "False" "High" "IsMasterProtein" "O75368" "Adapter SH3BGRL OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1" "0.000" "False" "86.571" "84" "8" "24" "8" "114" "12.8" "5.25" "97.51" "8" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04908" "6451" "ENSG00000131171" "SH3BGRL" "hsa:6451; O75368; Q3SYL1; Q5JT50; Q6FIE8; Q9H0N8" "" "" "0" "0" "1.033" "1.049" "1.054" "1.027" "1.140" "1.063" "1.085" "1.021" "1.037" "2993.0" "3092.0" "3138.4" "3155.9" "3073.5" "3410.9" "3181.6" "3247.0" "3054.8" "3103.4" "" "" "" "" "" "" "" "" "" "" "2404.0" "2231.1" "2493.0" "2114.5" "2125.6" "2559.1" "2227.6" "2371.3" "3054.8" "2523.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450891647387080638" "False" "High" "IsMasterProtein" "Q9BUL8" "Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1" "0.000" "False" "86.538" "55" "9" "24" "9" "212" "24.7" "8.19" "86.73" "9" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06840, Pf20929" "11235" "ENSG00000114209" "PDCD10" "A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8" "" "" "0" "0" "0.996" "0.979" "0.966" "1.006" "1.007" "0.977" "1.012" "1.020" "0.993" "2278.0" "2269.8" "2230.6" "2201.5" "2292.6" "2292.9" "2224.7" "2305.0" "2323.0" "2262.3" "" "" "" "" "" "" "" "" "" "" "1829.7" "1637.8" "1771.9" "1475.0" "1585.6" "1720.3" "1557.6" "1683.4" "2323.0" "1839.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6534553132144552728" "False" "High" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "0.000" "False" "86.462" "29" "10" "28" "6" "425" "47.6" "4.89" "91.08" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "HCMV Early Events; RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in progeria; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "28" "3" "0.967" "1.026" "0.960" "0.941" "0.949" "0.962" "0.998" "1.018" "0.957" "2785.9" "2694.2" "2859.1" "2674.6" "2621.8" "2644.8" "2679.3" "2780.2" "2837.3" "2666.5" "" "" "" "" "" "" "" "" "" "" "2237.6" "1944.1" "2271.1" "1792.0" "1813.3" "1984.4" "1875.9" "2030.4" "2837.3" "2168.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1217217274349295091" "False" "High" "IsMasterProtein" "Q9Y4E8" "Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3" "0.000" "False" "86.358" "21" "20" "28" "18" "981" "112.3" "5.22" "96.36" "20" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "9958" "ENSG00000135655" "USP15" "hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5" "Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling" "" "3" "1" "0.994" "1.024" "0.964" "0.980" "0.988" "0.984" "0.996" "0.997" "0.979" "1802.6" "1792.7" "1845.6" "1737.9" "1766.2" "1780.2" "1774.7" "1796.2" "1797.2" "1764.4" "" "" "" "" "" "" "" "" "" "" "1447.8" "1293.6" "1466.0" "1164.4" "1221.5" "1335.7" "1242.5" "1311.8" "1797.2" "1434.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1511141278890819027" "False" "High" "IsMasterProtein" "O14802" "DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2" "0.000" "False" "86.189" "17" "22" "27" "21" "1390" "155.5" "8.48" "73.65" "22" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "11128" "ENSG00000148606" "POLR3A" "hsa:11128; O14802; Q8IW34; Q8TCW5" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway" "9" "0" "0.982" "1.004" "0.969" "0.949" "0.967" "0.950" "0.945" "0.969" "0.970" "1229.1" "1206.7" "1233.6" "1190.6" "1166.0" "1188.2" "1167.9" "1161.1" "1191.3" "1192.3" "" "" "" "" "" "" "" "" "" "" "987.2" "870.7" "979.9" "797.7" "806.4" "891.5" "817.7" "848.0" "1191.3" "969.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815926444524445653" "False" "High" "IsMasterProtein" "Q7Z406" "Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2" "0.000" "False" "86.186" "4" "10" "34" "1" "1995" "227.7" "5.60" "121.98" "10" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "79784" "ENSG00000105357" "MYH14" "B0I1S2; C3TTN4; hsa:79784; Q5CZ75; Q6XYE4; Q76B62; Q7Z406; Q8WV23; Q96I22; Q9BT27; Q9BW35; Q9H882" "EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases activate PAKs" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7164252361216930989" "False" "High" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "0.000" "False" "86.154" "32" "9" "29" "9" "260" "30.5" "5.21" "109.15" "9" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Pyrimidine salvage; Purine salvage" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "4" "0" "0.989" "1.027" "0.960" "1.005" "1.032" "0.918" "0.958" "0.943" "0.968" "3241.1" "3206.9" "3329.9" "3111.9" "3257.6" "3343.3" "2974.1" "3105.1" "3055.7" "3138.6" "" "" "" "" "" "" "" "" "" "" "2603.2" "2314.0" "2645.1" "2084.9" "2253.0" "2508.4" "2082.3" "2267.7" "3055.7" "2552.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2364171353668644168" "False" "High" "IsMasterProtein" "Q00653" "Nuclear factor NF-kappa-B p100 subunit OS=Homo sapiens OX=9606 GN=NFKB2 PE=1 SV=4" "0.000" "False" "86.115" "23" "18" "25" "18" "900" "96.7" "6.25" "81.64" "18" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4791" "ENSG00000077150" "NFKB2" "A8K9D9; D3DR83; hsa:4791; Q00653; Q04860; Q9BU75; Q9H471; Q9H472" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; Interleukin-1 processing; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus infection in host; Breast cancer pathway; Acute viral myocarditis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "43" "0" "1.012" "0.984" "1.032" "1.034" "1.027" "1.044" "1.069" "1.092" "1.038" "2384.8" "2412.6" "2346.2" "2461.7" "2465.4" "2448.6" "2489.1" "2550.5" "2604.5" "2474.9" "" "" "" "" "" "" "" "" "" "" "1915.4" "1740.9" "1863.6" "1649.3" "1705.1" "1837.1" "1742.8" "1862.7" "2604.5" "2012.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-997186877852076993" "False" "High" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "0.000" "False" "86.092" "43" "13" "22" "13" "352" "39.6" "5.19" "76.21" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "Striated Muscle Contraction; RND3 GTPase cycle; RHOBTB2 GTPase cycle" "VEGFA-VEGFR2 signaling" "4" "0" "0.987" "0.963" "1.023" "1.063" "1.053" "1.142" "1.067" "1.144" "1.056" "1450.2" "1430.9" "1396.3" "1483.7" "1541.8" "1526.8" "1656.7" "1547.1" "1659.3" "1530.9" "" "" "" "" "" "" "" "" "" "" "1164.8" "1032.5" "1109.1" "994.1" "1066.3" "1145.6" "1160.0" "1129.8" "1659.3" "1245.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3022549876159517749" "False" "High" "IsMasterProtein" "Q9H8W4" "Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens OX=9606 GN=PLEKHF2 PE=1 SV=1" "0.000" "False" "85.834" "59" "11" "24" "10" "249" "27.8" "8.21" "79.72" "11" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00169, Pf01363" "79666" "ENSG00000175895" "PLEKHF2" "hsa:79666; Q9H8W4" "" "" "0" "1" "0.977" "0.949" "0.953" "1.006" "0.961" "0.981" "0.952" "0.948" "0.994" "1416.8" "1384.3" "1344.5" "1350.6" "1425.8" "1361.3" "1389.3" "1348.6" "1343.4" "1408.7" "" "" "" "" "" "" "" "" "" "" "1138.0" "998.9" "1068.0" "904.9" "986.1" "1021.4" "972.7" "984.9" "1343.4" "1145.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971041458510100973" "False" "High" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "0.000" "False" "85.803" "33" "13" "22" "13" "443" "51.6" "5.53" "74.11" "13" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "Ciliary landscape" "6" "0" "0.995" "0.987" "1.007" "0.944" "0.972" "0.974" "0.992" "0.936" "1.013" "1528.2" "1519.9" "1507.6" "1539.5" "1442.0" "1484.7" "1488.1" "1516.0" "1430.9" "1548.1" "" "" "" "" "" "" "" "" "" "" "1227.4" "1096.7" "1197.6" "1031.5" "997.3" "1114.0" "1041.9" "1107.2" "1430.9" "1258.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "721169718826189063" "False" "High" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "0.000" "False" "85.693" "24" "25" "35" "25" "1150" "132.7" "5.76" "91.48" "25" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "mRNA Splicing - Major Pathway" "" "1" "0" "0.923" "0.978" "0.985" "1.021" "1.047" "1.034" "0.978" "0.984" "1.043" "2699.4" "2490.6" "2640.9" "2660.3" "2757.0" "2825.4" "2792.4" "2638.8" "2654.9" "2815.1" "" "" "" "" "" "" "" "" "" "" "2168.2" "1797.2" "2097.8" "1782.4" "1906.8" "2119.8" "1955.1" "1927.1" "2654.9" "2289.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1761258682097812184" "False" "High" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "0.000" "False" "85.682" "32" "11" "23" "11" "450" "50.8" "7.43" "85.00" "11" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "0.986" "0.985" "0.996" "0.959" "0.976" "0.922" "0.927" "0.928" "0.979" "2624.4" "2587.5" "2585.5" "2613.0" "2517.9" "2561.1" "2419.8" "2432.9" "2435.3" "2568.6" "" "" "" "" "" "" "" "" "" "" "2107.9" "1867.0" "2053.8" "1750.7" "1741.4" "1921.5" "1694.2" "1776.7" "2435.3" "2088.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2439136335340173205" "False" "High" "IsMasterProtein" "P22681" "E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2" "0.000" "False" "85.598" "21" "13" "17" "12" "906" "99.6" "6.54" "57.94" "13" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762" "867" "ENSG00000110395" "CBL" "A3KMP8; P22681" "Spry regulation of FGF signaling; Regulation of signaling by CBL; Regulation of KIT signaling; Negative regulation of FLT3; Cargo recognition for clathrin-mediated endocytosis; Interleukin-6 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Signaling by CSF1 (M-CSF) in myeloid cells; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; FLT3 signaling by CBL mutants" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Insulin signaling; IL-2 signaling pathway; 4p16.3 copy number variation; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "39" "1" "1.053" "1.064" "1.061" "1.032" "1.012" "0.993" "0.990" "1.006" "1.071" "1010.2" "1063.6" "1074.5" "1071.8" "1042.4" "1022.0" "1002.8" "1000.1" "1016.6" "1081.5" "" "" "" "" "" "" "" "" "" "" "811.3" "767.5" "853.5" "718.1" "720.9" "766.8" "702.1" "730.4" "1016.6" "879.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8500687369034294287" "False" "High" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "0.000" "False" "85.584" "61" "11" "27" "3" "205" "22.7" "6.21" "92.81" "11" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "" "6" "0" "1.060" "1.060" "1.032" "1.056" "1.027" "0.959" "1.091" "1.137" "1.087" "605.8" "642.0" "642.5" "625.4" "639.8" "622.3" "580.8" "660.8" "688.8" "658.5" "" "" "" "" "" "" "" "" "" "" "486.6" "463.3" "510.3" "419.0" "442.5" "466.9" "406.7" "482.6" "688.8" "535.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257366520332167042" "False" "High" "IsMasterProtein" "Q13422" "DNA-binding protein Ikaros OS=Homo sapiens OX=9606 GN=IKZF1 PE=1 SV=1" "0.000" "False" "85.540" "34" "14" "21" "10" "519" "57.5" "6.58" "74.68" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10320" "ENSG00000185811" "IKZF1" "A4D260; B4E0Z1; D3DVM5; hsa:10320; O00598; Q13422; Q53XL2; Q69BM4; Q8WVA3" "" "Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets" "2" "2" "1.075" "1.054" "1.041" "1.016" "1.073" "1.023" "1.062" "1.037" "1.045" "1197.9" "1287.1" "1262.0" "1247.0" "1217.4" "1285.2" "1225.7" "1272.5" "1241.6" "1252.2" "" "" "" "" "" "" "" "" "" "" "962.1" "928.8" "1002.4" "835.5" "841.9" "964.3" "858.2" "929.3" "1241.6" "1018.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5278147799990617038" "False" "High" "IsMasterProtein" "P78318" "Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1" "0.000" "False" "85.456" "35" "11" "18" "11" "339" "39.2" "5.38" "64.20" "11" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf04177" "3476" "ENSG00000089289" "IGBP1" "P78318; Q8TAB2" "" "16p11.2 proximal deletion syndrome" "1" "0" "1.018" "0.940" "1.028" "1.001" "1.002" "1.037" "0.977" "1.000" "1.007" "1534.3" "1561.1" "1442.7" "1577.5" "1535.8" "1538.0" "1590.5" "1498.3" "1534.5" "1545.0" "" "" "" "" "" "" "" "" "" "" "1232.3" "1126.5" "1146.0" "1056.9" "1062.1" "1154.0" "1113.6" "1094.2" "1534.5" "1256.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1748573463469303870" "False" "High" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "0.000" "False" "85.332" "28" "17" "25" "16" "725" "81.3" "7.83" "78.52" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "Microtubule cytoskeleton regulation" "10" "0" "1.001" "0.957" "0.978" "0.984" "0.960" "0.928" "1.020" "0.994" "0.996" "2027.5" "2030.3" "1940.5" "1983.3" "1994.9" "1946.7" "1881.4" "2067.3" "2016.1" "2018.7" "" "" "" "" "" "" "" "" "" "" "1628.4" "1465.0" "1541.4" "1328.8" "1379.7" "1460.6" "1317.3" "1509.8" "2016.1" "1641.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6821815504623325969" "False" "High" "IsMasterProtein" "Q9UMX0" "Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2" "0.000" "False" "85.322" "24" "9" "26" "4" "589" "62.5" "5.11" "103.95" "9" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29979" "ENSG00000135018" "UBQLN1" "A0A024R284; hsa:29979; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; Q9UMX0" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "1" "1.034" "1.047" "1.084" "1.020" "1.091" "1.033" "1.091" "1.030" "1.074" "610.6" "631.1" "639.4" "661.9" "622.6" "666.3" "631.0" "666.1" "628.7" "655.9" "" "" "" "" "" "" "" "" "" "" "490.4" "455.4" "507.9" "443.5" "430.6" "499.9" "441.8" "486.5" "628.7" "533.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "774032980472200148" "False" "High" "IsMasterProtein" "P80404" "4-aminobutyrate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ABAT PE=1 SV=3" "0.000" "False" "85.316" "32" "14" "17" "14" "500" "56.4" "7.96" "64.66" "14" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00202" "18" "ENSG00000183044" "ABAT" "A8K386; hsa:18; P80404; Q16260; Q8N5W2; Q96BG2; Q99800" "Degradation of GABA" "Alanine and aspartate metabolism; Valproic acid pathway; Fragile X syndrome" "4" "0" "1.023" "0.960" "1.030" "1.034" "0.992" "0.948" "1.005" "0.976" "1.023" "1597.7" "1634.1" "1533.5" "1645.3" "1651.5" "1585.2" "1515.1" "1605.8" "1559.3" "1634.0" "" "" "" "" "" "" "" "" "" "" "1283.2" "1179.2" "1218.1" "1102.4" "1142.2" "1189.3" "1060.8" "1172.7" "1559.3" "1328.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3997402182379015815" "False" "High" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "0.000" "False" "85.225" "37" "14" "19" "14" "548" "63.9" "6.05" "70.76" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "9" "0" "0.965" "1.075" "1.009" "1.040" "1.067" "1.050" "1.013" "1.007" "1.056" "1117.5" "1078.5" "1201.7" "1127.9" "1162.4" "1192.1" "1173.5" "1132.5" "1125.6" "1180.5" "" "" "" "" "" "" "" "" "" "" "897.5" "778.2" "954.6" "755.7" "803.9" "894.4" "821.6" "827.1" "1125.6" "960.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400550207963658767" "False" "High" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "0.000" "False" "85.158" "33" "13" "23" "13" "499" "55.4" "5.78" "85.13" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "mRNA Splicing - Major Pathway" "" "1" "0" "1.012" "0.960" "0.965" "1.024" "0.989" "0.939" "1.021" "1.024" "0.998" "1427.6" "1444.6" "1370.8" "1377.5" "1461.5" "1411.6" "1340.1" "1457.1" "1461.4" "1425.3" "" "" "" "" "" "" "" "" "" "" "1146.6" "1042.4" "1088.9" "922.9" "1010.8" "1059.1" "938.3" "1064.1" "1461.4" "1159.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639457363078970209" "False" "High" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "0.000" "False" "85.122" "35" "15" "38" "15" "375" "42.6" "8.56" "115.94" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome" "5" "0" "1.071" "1.133" "1.114" "1.149" "1.032" "1.087" "1.131" "1.084" "1.086" "3052.6" "3268.3" "3458.1" "3400.1" "3508.0" "3151.2" "3318.5" "3452.2" "3307.7" "3313.9" "" "" "" "" "" "" "" "" "" "" "2451.8" "2358.3" "2746.9" "2278.1" "2426.2" "2364.3" "2323.4" "2521.2" "3307.7" "2695.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1871609499973025843" "False" "High" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "0.000" "False" "85.018" "34" "5" "28" "5" "282" "31.3" "4.84" "101.94" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "8" "0" "1.027" "0.975" "0.946" "0.979" "0.974" "0.992" "0.965" "0.950" "0.919" "2057.3" "2113.6" "2006.5" "1945.5" "2013.2" "2004.7" "2040.0" "1986.0" "1954.6" "1890.8" "" "" "" "" "" "" "" "" "" "" "1652.4" "1525.1" "1593.9" "1303.5" "1392.4" "1504.1" "1428.3" "1450.4" "1954.6" "1537.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8717421015690566095" "False" "High" "IsMasterProtein" "Q9NQR4" "Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1" "0.000" "False" "84.976" "60" "14" "23" "14" "276" "30.6" "7.21" "79.10" "14" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00795" "56954" "ENSG00000114021" "NIT2" "B2R9A3; D3DN47; hsa:56954; Q8WUF0; Q9NQR4" "Neutrophil degranulation" "" "1" "0" "0.957" "0.999" "0.936" "0.950" "0.999" "0.923" "0.960" "0.935" "0.948" "1940.6" "1857.9" "1938.5" "1815.4" "1844.1" "1937.9" "1791.2" "1863.0" "1814.6" "1840.1" "" "" "" "" "" "" "" "" "" "" "1558.6" "1340.6" "1539.8" "1216.3" "1275.4" "1454.0" "1254.1" "1360.5" "1814.6" "1496.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6717857941727919032" "False" "High" "IsMasterProtein" "Q8WZA9" "Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1" "0.000" "False" "84.800" "24" "12" "19" "12" "623" "62.7" "4.88" "67.96" "12" "" "" "other molecular function" "" "126298" "ENSG00000167378" "IRGQ" "B2RNP3; hsa:126298; Q8WZA9" "" "" "0" "0" "1.008" "0.960" "1.057" "1.014" "0.978" "1.070" "1.017" "1.065" "1.025" "1230.4" "1240.6" "1181.2" "1300.6" "1247.4" "1203.9" "1316.9" "1251.5" "1310.4" "1260.8" "" "" "" "" "" "" "" "" "" "" "988.3" "895.2" "938.3" "871.4" "862.7" "903.3" "922.0" "914.0" "1310.4" "1025.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "769140260772308897" "False" "High" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "0.000" "False" "84.726" "36" "12" "30" "12" "306" "33.7" "5.08" "99.27" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "6" "0" "0.881" "1.063" "0.933" "0.807" "0.944" "1.051" "1.060" "1.007" "0.941" "2294.1" "2021.5" "2439.4" "2139.8" "1850.7" "2165.9" "2410.2" "2431.8" "2309.8" "2158.4" "" "" "" "" "" "" "" "" "" "" "1842.6" "1458.7" "1937.7" "1433.7" "1280.0" "1625.0" "1687.5" "1776.0" "2309.8" "1755.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7548254055495868617" "False" "High" "IsMasterProtein" "Q9BZD4" "Kinetochore protein Nuf2 OS=Homo sapiens OX=9606 GN=NUF2 PE=1 SV=2" "0.000" "False" "84.709" "28" "13" "20" "13" "464" "54.3" "8.27" "77.17" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03800" "83540" "ENSG00000143228" "NUF2" "hsa:83540; Q8WU69; Q96HJ4; Q96Q78; Q9BZD4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.032" "1.014" "1.024" "0.989" "0.967" "0.937" "0.930" "0.931" "0.961" "2356.1" "2430.7" "2389.2" "2412.3" "2330.0" "2278.2" "2208.2" "2191.3" "2194.6" "2264.5" "" "" "" "" "" "" "" "" "" "" "1892.4" "1753.9" "1897.8" "1616.2" "1611.5" "1709.3" "1546.0" "1600.3" "2194.6" "1841.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914361862769815360" "False" "High" "IsMasterProtein" "O00507" "Ubiquitin carboxyl-terminal hydrolase 9Y OS=Homo sapiens OX=9606 GN=USP9Y PE=1 SV=2" "0.000" "False" "84.694" "9" "23" "26" "1" "2555" "290.9" "5.86" "76.28" "23" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8287" "ENSG00000114374" "USP9Y" "hsa:8287; O00507; O14601" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "906200433272310872" "False" "High" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "0.000" "False" "84.446" "38" "14" "21" "14" "432" "47.6" "5.97" "85.00" "14" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Neutrophil degranulation" "VEGFA-VEGFR2 signaling" "4" "0" "0.970" "0.970" "0.897" "0.987" "0.972" "1.000" "1.020" "0.997" "0.995" "1654.8" "1605.8" "1605.9" "1484.6" "1633.5" "1609.1" "1654.9" "1687.3" "1650.5" "1647.3" "" "" "" "" "" "" "" "" "" "" "1329.1" "1158.7" "1275.6" "994.7" "1129.8" "1207.3" "1158.7" "1232.2" "1650.5" "1339.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631621731617011436" "False" "High" "IsMasterProtein" "Q12955" "Ankyrin-3 OS=Homo sapiens OX=9606 GN=ANK3 PE=1 SV=3" "0.000" "False" "84.360" "4" "16" "19" "16" "4377" "480.1" "6.49" "67.83" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00531, Pf00791, Pf12796, Pf17809" "288" "ENSG00000151150" "ANK3" "B1AQT2; B4DIL1; E9PE32; hsa:288; Q12955; Q13484; Q5CZH9; Q5VXD5; Q7Z3G4; Q9H0P5" "COPI-mediated anterograde transport; Interaction between L1 and Ankyrins" "Splicing factor NOVA regulated synaptic proteins" "3" "0" "1.009" "0.972" "1.012" "0.985" "1.033" "0.905" "0.917" "1.002" "0.963" "1664.5" "1678.8" "1617.6" "1685.2" "1638.8" "1719.2" "1506.2" "1527.0" "1668.0" "1602.9" "" "" "" "" "" "" "" "" "" "" "1336.9" "1211.4" "1284.9" "1129.1" "1133.4" "1289.9" "1054.6" "1115.2" "1668.0" "1303.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-355239685975103350" "False" "High" "IsMasterProtein" "O14578" "Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2" "0.000" "False" "84.155" "10" "20" "25" "20" "2027" "231.3" "6.57" "77.66" "20" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "cytosol" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433, Pf00780" "11113" "ENSG00000122966" "CIT" "hsa:11113; O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHO GTPases activate CIT" "Pleural mesothelioma; G13 signaling pathway" "7" "0" "1.017" "0.968" "1.102" "1.058" "0.953" "1.135" "1.077" "0.989" "1.017" "1098.5" "1117.6" "1063.0" "1210.4" "1162.0" "1046.9" "1246.3" "1183.1" "1086.5" "1117.4" "" "" "" "" "" "" "" "" "" "" "882.3" "806.4" "844.4" "811.0" "803.6" "785.5" "872.6" "864.0" "1086.5" "908.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6099589946817253427" "False" "High" "IsMasterProtein" "Q7Z417" "FMR1-interacting protein NUFIP2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "0.000" "False" "84.153" "27" "13" "19" "13" "695" "76.1" "8.70" "68.26" "13" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "1.041" "1.063" "1.072" "1.146" "1.116" "1.124" "1.147" "1.149" "1.077" "1113.4" "1158.9" "1183.4" "1193.6" "1275.9" "1242.2" "1252.0" "1277.0" "1279.4" "1199.6" "" "" "" "" "" "" "" "" "" "" "894.3" "836.2" "940.0" "799.7" "882.4" "932.0" "876.6" "932.6" "1279.4" "975.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848628119440074227" "False" "High" "IsMasterProtein" "P30038" "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH4A1 PE=1 SV=3" "0.000" "False" "84.117" "25" "12" "18" "12" "563" "61.7" "8.07" "68.63" "12" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00171" "8659" "ENSG00000159423" "ALDH4A1" "A8K1Q7; B4DGE4; D2D4A3; hsa:8659; P30038; Q16882; Q53HU4; Q5JNV6; Q8IZ38; Q96IF0; Q9UDI6" "Glyoxylate metabolism and glycine degradation; Proline catabolism" "22q11.2 copy number variation syndrome; p53 transcriptional gene network" "4" "0" "0.979" "0.993" "0.991" "1.042" "1.000" "0.988" "0.971" "0.975" "1.022" "2455.9" "2404.1" "2438.7" "2435.0" "2558.5" "2456.6" "2426.0" "2384.2" "2394.0" "2510.5" "" "" "" "" "" "" "" "" "" "" "1972.6" "1734.8" "1937.1" "1631.4" "1769.5" "1843.2" "1698.6" "1741.2" "2394.0" "2041.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6199563702112544119" "False" "High" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "0.000" "False" "84.084" "20" "16" "22" "16" "938" "102.9" "7.02" "72.89" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "0.983" "0.974" "1.024" "1.016" "1.000" "1.008" "0.957" "1.006" "1.032" "1458.0" "1433.0" "1420.7" "1492.3" "1480.7" "1458.2" "1469.8" "1395.6" "1466.0" "1505.2" "" "" "" "" "" "" "" "" "" "" "1171.0" "1034.0" "1128.5" "999.8" "1024.0" "1094.0" "1029.1" "1019.2" "1466.0" "1224.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5142259406840293622" "False" "High" "IsMasterProtein" "Q14738" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens OX=9606 GN=PPP2R5D PE=1 SV=1" "0.000" "False" "84.009" "27" "15" "23" "12" "602" "69.9" "8.13" "81.87" "15" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5528" "ENSG00000112640" "PPP2R5D" "A8K3I9; B5BUA6; hsa:5528; O00494; O00696; Q14738; Q15171; Q5TC39" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; DARPP-32 events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "33" "1" "0.996" "1.009" "0.989" "0.994" "1.048" "0.971" "0.991" "1.047" "1.030" "2191.1" "2181.5" "2210.6" "2166.3" "2178.2" "2295.6" "2126.5" "2172.4" "2295.1" "2255.9" "" "" "" "" "" "" "" "" "" "" "1759.9" "1574.1" "1755.9" "1451.4" "1506.5" "1722.3" "1488.9" "1586.5" "2295.1" "1834.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552145293122951673" "False" "High" "IsMasterProtein" "Q96P48" "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3" "0.000" "False" "83.997" "17" "20" "24" "20" "1450" "162.1" "6.23" "85.31" "20" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00536, Pf00620, Pf00788, Pf01412" "116985" "ENSG00000186635" "ARAP1" "A3KLL7; B2RTS2; hsa:116985; O94879; Q4LDD5; Q59FI7; Q6PHS3; Q8WU51; Q96HP6; Q96L71; Q96P48" "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "" "4" "0" "1.104" "1.015" "1.037" "1.153" "1.051" "0.994" "1.090" "1.037" "1.070" "1148.0" "1267.6" "1165.7" "1190.1" "1324.3" "1206.4" "1141.3" "1251.8" "1190.7" "1228.0" "" "" "" "" "" "" "" "" "" "" "922.1" "914.7" "925.9" "797.4" "915.9" "905.2" "799.1" "914.2" "1190.7" "998.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198800325193539681" "False" "High" "IsMasterProtein" "P30050" "Large ribosomal subunit protein uL11 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "0.000" "False" "83.990" "68" "9" "18" "9" "165" "17.8" "9.42" "68.87" "9" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.856" "1.066" "1.008" "1.038" "1.099" "1.230" "1.052" "1.043" "0.971" "1351.2" "1156.0" "1440.4" "1361.7" "1402.1" "1484.5" "1662.7" "1421.6" "1409.0" "1312.0" "" "" "" "" "" "" "" "" "" "" "1085.3" "834.1" "1144.2" "912.3" "969.7" "1113.8" "1164.1" "1038.2" "1409.0" "1066.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3873794915793825420" "False" "High" "IsMasterProtein" "Q9BYT8" "Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1" "0.000" "False" "83.989" "24" "15" "23" "15" "704" "80.6" "6.64" "72.23" "15" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf01432" "57486" "ENSG00000123213" "NLN" "hsa:57486; Q9BYT8; Q9ULJ4" "Peptide ligand-binding receptors" "" "1" "0" "0.993" "0.985" "0.962" "1.017" "1.019" "0.959" "0.990" "0.965" "1.006" "1712.7" "1700.6" "1687.5" "1646.9" "1742.2" "1744.4" "1642.5" "1695.2" "1653.5" "1722.6" "" "" "" "" "" "" "" "" "" "" "1375.6" "1227.1" "1340.4" "1103.4" "1204.9" "1308.8" "1150.0" "1238.0" "1653.5" "1400.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4972619903535100006" "False" "High" "IsMasterProtein" "P49916" "DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2" "0.000" "False" "83.969" "17" "15" "25" "15" "1009" "112.8" "9.01" "79.84" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00645, Pf01068, Pf04675, Pf04679, Pf16759" "3980" "ENSG00000005156" "LIG3" "E5KLB5; E5KLB6; hsa:3980; P49916; Q16714; Q6NVK3" "HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 17q12 copy number variation syndrome" "9" "0" "1.044" "1.021" "1.070" "1.069" "1.074" "1.046" "1.076" "1.088" "1.041" "2092.8" "2185.4" "2136.2" "2238.7" "2237.7" "2247.1" "2189.4" "2252.4" "2276.5" "2178.4" "" "" "" "" "" "" "" "" "" "" "1680.9" "1576.9" "1696.9" "1499.9" "1547.6" "1686.0" "1532.9" "1644.9" "2276.5" "1771.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314781854584049203" "False" "High" "IsMasterProtein" "O75436" "Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2" "0.000" "False" "83.908" "49" "14" "24" "13" "327" "38.1" "6.57" "81.35" "14" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "9559" "ENSG00000122958" "VPS26A" "A8MZ56; B2RDD3; hsa:9559; O75436; Q8TBH4; Q9H982" "WNT ligand biogenesis and trafficking" "" "1" "1" "1.011" "1.039" "0.985" "0.982" "1.023" "0.942" "0.969" "0.949" "1.019" "2059.9" "2082.5" "2141.0" "2029.7" "2023.5" "2106.7" "1940.6" "1996.5" "1954.8" "2099.1" "" "" "" "" "" "" "" "" "" "" "1654.5" "1502.7" "1700.7" "1359.9" "1399.5" "1580.6" "1358.7" "1458.1" "1954.8" "1707.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119671646432562357" "False" "High" "IsMasterProtein" "P13929" "Beta-enolase OS=Homo sapiens OX=9606 GN=ENO3 PE=1 SV=5" "0.000" "False" "83.771" "24" "8" "82" "1" "434" "47.0" "7.71" "293.74" "8" "other metabolic processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00113, Pf03952" "2027" "ENSG00000108515" "ENO3" "B4DUI6; B4DUM6; D3DTL2; E7ENK8; hsa:2027; P13929; Q96AE2" "Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "0" "1.077" "1.056" "1.152" "0.976" "1.034" "1.030" "0.965" "1.130" "1.034" "221.5" "238.4" "233.8" "255.2" "216.1" "228.9" "228.1" "213.8" "250.2" "229.1" "" "" "" "" "" "" "" "" "" "" "177.9" "172.0" "185.7" "171.0" "149.5" "171.8" "159.7" "156.2" "250.2" "186.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "185652229165611282" "False" "High" "IsMasterProtein" "Q9NY27" "Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3" "0.000" "False" "83.730" "33" "9" "17" "9" "417" "46.9" "4.54" "60.79" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09184" "151987" "ENSG00000163605" "PPP4R2" "A8K1I6; hsa:151987; Q2TAJ9; Q498B8; Q8WXX6; Q9NY27" "Processing of DNA double-strand break ends" "16p11.2 proximal deletion syndrome" "2" "0" "1.049" "1.024" "1.016" "0.946" "0.995" "0.951" "0.913" "0.961" "0.993" "662.9" "695.5" "678.8" "673.4" "627.3" "659.6" "630.1" "605.3" "637.1" "658.4" "" "" "" "" "" "" "" "" "" "" "532.4" "501.8" "539.2" "451.2" "433.9" "494.9" "441.2" "442.0" "637.1" "535.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5023215591343920566" "False" "High" "IsMasterProtein" "Q12768" "WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1" "0.000" "False" "83.710" "16" "17" "21" "17" "1159" "134.2" "6.98" "72.58" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf10266" "9897" "ENSG00000164961" "WASHC5" "A8K4R7; hsa:9897; Q12768; Q3KQX5; Q8TBQ2" "" "" "0" "0" "1.068" "1.013" "1.070" "1.011" "0.983" "0.980" "0.981" "0.965" "1.010" "1090.1" "1163.8" "1104.4" "1165.9" "1101.9" "1071.9" "1067.9" "1069.0" "1051.7" "1101.5" "" "" "" "" "" "" "" "" "" "" "875.6" "839.8" "877.3" "781.2" "762.1" "804.2" "747.7" "780.7" "1051.7" "895.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7216673517695953879" "False" "High" "IsMasterProtein" "Q8TDZ2" "[F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2" "0.000" "False" "83.692" "14" "13" "17" "13" "1067" "117.8" "6.40" "58.81" "13" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "64780" "ENSG00000135596" "MICAL1" "B7Z3R5; E1P5F0; Q7Z633; Q8IVS9; Q8TDZ2; Q96G47; Q9H6X6; Q9H7I0; Q9HAA1; Q9UFF7" "Factors involved in megakaryocyte development and platelet production" "" "1" "0" "0.958" "1.064" "0.991" "0.963" "1.036" "1.005" "0.924" "1.007" "1.024" "934.8" "895.8" "994.2" "926.1" "900.5" "968.2" "939.6" "863.8" "941.3" "956.9" "" "" "" "" "" "" "" "" "" "" "750.8" "646.4" "789.7" "620.5" "622.8" "726.4" "657.8" "630.8" "941.3" "778.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271910638518906992" "False" "High" "IsMasterProtein" "Q92552" "Small ribosomal subunit protein mS27 OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "0.000" "False" "83.673" "25" "8" "17" "8" "414" "47.6" "6.18" "69.45" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.020" "0.967" "0.991" "0.993" "0.956" "0.951" "1.033" "1.012" "1.020" "996.7" "1016.5" "963.9" "987.3" "989.3" "953.3" "947.4" "1029.2" "1008.3" "1016.4" "" "" "" "" "" "" "" "" "" "" "800.6" "733.5" "765.6" "661.5" "684.2" "715.3" "663.3" "751.6" "1008.3" "826.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6856624260157841827" "False" "High" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "0.000" "False" "83.645" "43" "11" "24" "9" "369" "40.9" "7.44" "90.84" "11" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "2" "1.051" "1.020" "1.026" "1.008" "0.999" "1.064" "0.978" "1.011" "1.047" "1103.4" "1159.8" "1125.3" "1132.4" "1112.5" "1102.7" "1173.7" "1078.8" "1115.7" "1154.8" "" "" "" "" "" "" "" "" "" "" "886.2" "836.9" "893.9" "758.7" "769.4" "827.3" "821.8" "787.8" "1115.7" "939.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988285782465549683" "False" "High" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "0.000" "False" "83.633" "29" "11" "22" "11" "399" "44.2" "4.73" "75.75" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "Polymerase switching on the C-strand of the telomere; Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "16" "0" "0.933" "0.929" "0.925" "1.011" "1.069" "0.984" "1.028" "1.001" "1.019" "1592.8" "1486.9" "1479.4" "1474.0" "1609.6" "1702.9" "1567.2" "1637.1" "1594.1" "1623.1" "" "" "" "" "" "" "" "" "" "" "1279.3" "1072.9" "1175.1" "987.6" "1113.2" "1277.6" "1097.3" "1195.6" "1594.1" "1320.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541335516874274105" "False" "High" "IsMasterProtein" "Q14527" "Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2" "0.000" "False" "83.480" "19" "18" "24" "18" "1009" "113.9" "8.60" "69.71" "18" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf08797, Pf13923" "6596" "ENSG00000071794" "HLTF" "D3DNH3; Q14527; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9" "E3 ubiquitin ligases ubiquitinate target proteins" "Retinoblastoma gene in cancer" "2" "0" "1.049" "1.021" "1.002" "1.008" "0.989" "0.947" "1.005" "1.066" "1.017" "1143.9" "1200.4" "1168.3" "1146.6" "1153.6" "1131.6" "1083.2" "1150.0" "1219.1" "1162.9" "" "" "" "" "" "" "" "" "" "" "918.8" "866.2" "928.0" "768.2" "797.9" "849.0" "758.4" "839.9" "1219.1" "945.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2776993726351284183" "False" "High" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "0.000" "False" "83.444" "19" "12" "14" "12" "771" "87.9" "7.87" "59.91" "12" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.959" "1.049" "1.043" "1.075" "1.018" "1.111" "1.122" "1.086" "1.049" "1083.1" "1039.1" "1135.7" "1130.2" "1164.3" "1102.2" "1202.8" "1215.8" "1175.7" "1136.5" "" "" "" "" "" "" "" "" "" "" "870.0" "749.8" "902.1" "757.2" "805.2" "827.0" "842.2" "887.9" "1175.7" "924.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8004592446864816783" "False" "High" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "0.000" "False" "83.378" "29" "11" "27" "10" "479" "52.6" "5.05" "81.38" "11" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "MAPK signaling pathway" "4" "2" "0.990" "0.970" "1.018" "1.008" "0.960" "1.006" "0.943" "0.972" "1.031" "1569.3" "1553.5" "1521.5" "1597.3" "1581.6" "1507.3" "1578.0" "1480.6" "1524.8" "1617.4" "" "" "" "" "" "" "" "" "" "" "1260.5" "1121.0" "1208.5" "1070.2" "1093.8" "1130.9" "1104.9" "1081.3" "1524.8" "1315.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6258947584785222358" "False" "High" "IsMasterProtein" "P62906" "Large ribosomal subunit protein uL1 OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "0.000" "False" "83.315" "42" "9" "29" "9" "217" "24.8" "9.94" "96.79" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.968" "1.020" "1.026" "1.024" "1.064" "1.112" "1.005" "1.019" "0.998" "3059.5" "2962.3" "3121.4" "3138.6" "3133.0" "3254.0" "3401.8" "3073.3" "3119.0" "3052.9" "" "" "" "" "" "" "" "" "" "" "2457.4" "2137.5" "2479.4" "2102.8" "2166.8" "2441.4" "2381.8" "2244.4" "3119.0" "2482.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6739542972395274555" "False" "High" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "0.000" "False" "83.313" "12" "17" "25" "16" "1576" "171.4" "8.09" "73.67" "17" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "1" "0.994" "0.998" "1.056" "1.011" "0.981" "1.016" "0.971" "1.012" "0.994" "1375.7" "1367.3" "1373.2" "1453.2" "1391.5" "1349.2" "1398.2" "1336.0" "1392.0" "1367.4" "" "" "" "" "" "" "" "" "" "" "1105.0" "986.6" "1090.8" "973.6" "962.3" "1012.3" "979.0" "975.7" "1392.0" "1112.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3445317151605985554" "False" "High" "IsMasterProtein" "Q13356" "RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1" "0.000" "False" "83.175" "35" "15" "20" "15" "520" "58.8" "8.78" "68.32" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "23759" "ENSG00000100023" "PPIL2" "Q13356; Q13357; Q8TAH2; Q9BWR8" "mRNA Splicing - Major Pathway; Basigin interactions" "" "2" "0" "0.959" "0.951" "0.941" "0.948" "0.934" "0.884" "1.007" "1.015" "0.968" "1551.0" "1486.7" "1475.5" "1459.3" "1469.6" "1448.7" "1371.3" "1561.8" "1574.5" "1501.5" "" "" "" "" "" "" "" "" "" "" "1245.7" "1072.8" "1172.0" "977.7" "1016.4" "1086.9" "960.1" "1140.6" "1574.5" "1221.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570733689934674061" "False" "High" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "0.000" "False" "83.058" "64" "12" "29" "11" "215" "23.9" "6.21" "99.22" "12" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "7" "1" "0.943" "1.021" "0.964" "0.981" "0.946" "0.928" "0.971" "0.949" "0.953" "2963.6" "2796.1" "3025.1" "2856.7" "2906.0" "2803.4" "2750.9" "2876.8" "2812.2" "2824.1" "" "" "" "" "" "" "" "" "" "" "2380.3" "2017.6" "2402.9" "1914.0" "2009.8" "2103.3" "1926.1" "2101.0" "2812.2" "2296.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563010740913614584" "False" "High" "IsMasterProtein" "Q96EB6" "NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2" "0.000" "False" "83.037" "19" "11" "15" "11" "747" "81.6" "4.67" "55.70" "11" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23411" "ENSG00000096717" "SIRT1" "hsa:23411; Q2XNF6; Q5JVQ0; Q96EB6; Q9GZR9; Q9Y6F0" "SIRT1 negatively regulates rRNA expression; Regulation of HSF1-mediated heat shock response; Heme signaling; Circadian Clock; Regulation of FOXO transcriptional activity by acetylation" "Androgen receptor signaling pathway; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Melatonin metabolism and effects; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Interactions between LOXL4 and oxidative stress pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; CAMKK2 pathway; 3q29 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Inclusion body myositis; Prostaglandin and leukotriene metabolism in senescence ; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; 10q11.21q11.23 copy number variation syndrome; TAR syndrome; Omega-6-fatty acids in senescence" "27" "0" "0.995" "1.022" "1.082" "1.085" "1.051" "1.126" "1.124" "1.151" "1.087" "1892.9" "1883.6" "1933.8" "2047.5" "2053.7" "1988.6" "2130.5" "2127.9" "2178.8" "2058.0" "" "" "" "" "" "" "" "" "" "" "1520.4" "1359.1" "1536.1" "1371.8" "1420.4" "1492.0" "1491.7" "1554.0" "2178.8" "1673.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-629472087456424791" "False" "High" "IsMasterProtein" "Q09472" "Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2" "0.000" "False" "83.008" "9" "19" "21" "15" "2414" "264.0" "8.50" "64.41" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "2033" "ENSG00000100393" "EP300" "B1AKC2; hsa:2033; Q09472" "HATs acetylate histones; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation of granulopoiesis; Metalloprotease DUBs; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NGF-stimulated transcription; Heme signaling; Regulation of RUNX3 expression and activity; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; SUMOylation of transcription cofactors; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Methylation; NFE2L2 regulating anti-oxidant/detoxification enzymes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; NOTCH1 Intracellular Domain Regulates Transcription; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling; NFE2L2 regulating MDR associated enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; NOTCH3 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Polo-like kinase mediated events; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; RUNX3 regulates p14-ARF; Regulation of gene expression by Hypoxia-inducible Factor; PI5P Regulates TP53 Acetylation; NOTCH2 intracellular domain regulates transcription; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; IL-4 signaling pathway; Wnt signaling pathway and pluripotency; Prion disease pathway; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; CAMKK2 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; CCL18 signaling pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Urotensin-II-mediated signaling pathway; Pathophysiological roles of DUX4 in FSHD1; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "91" "4" "0.947" "0.961" "0.959" "0.958" "0.998" "0.966" "1.004" "0.998" "0.990" "982.1" "929.8" "943.7" "941.8" "940.9" "980.2" "948.4" "986.2" "980.2" "972.0" "" "" "" "" "" "" "" "" "" "" "788.8" "670.9" "749.6" "631.0" "650.8" "735.4" "664.0" "720.2" "980.2" "790.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6056072514061180880" "False" "High" "IsMasterProtein" "Q9Y2D5" "PALM2-AKAP2 fusion protein OS=Homo sapiens OX=9606 GN=PALM2AKAP2 PE=1 SV=4" "0.000" "False" "83.005" "16" "14" "22" "14" "1103" "122.0" "5.06" "77.74" "14" "" "plasma membrane;other membranes" "" "Pf03285, Pf15304" "445815" "ENSG00000157654" "PALM2AKAP2" "A9Z1X9; B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; hsa:445815; Q8IXS6; Q8N9D5; Q96DU1; Q9UG26; Q9Y2D5" "" "" "0" "0" "1.022" "0.938" "1.048" "1.092" "1.063" "1.112" "1.053" "1.097" "1.043" "1638.9" "1674.9" "1536.5" "1717.5" "1790.2" "1741.6" "1823.0" "1726.0" "1798.2" "1708.8" "" "" "" "" "" "" "" "" "" "" "1316.4" "1208.6" "1220.5" "1150.7" "1238.1" "1306.7" "1276.4" "1260.5" "1798.2" "1389.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6037717816811945701" "False" "High" "IsMasterProtein" "Q5T8P6" "RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3" "0.000" "False" "82.898" "17" "16" "26" "15" "1007" "113.5" "9.16" "87.20" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01480" "64062" "ENSG00000139746" "RBM26" "B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7" "" "" "0" "0" "0.956" "1.016" "0.976" "1.045" "1.005" "0.986" "1.042" "1.039" "1.013" "2412.4" "2306.2" "2451.5" "2355.7" "2520.7" "2425.6" "2379.8" "2513.8" "2506.1" "2444.3" "" "" "" "" "" "" "" "" "" "" "1937.6" "1664.1" "1947.3" "1578.3" "1743.3" "1819.9" "1666.2" "1835.8" "2506.1" "1987.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099504193891774007" "False" "High" "IsMasterProtein" "Q13557" "Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3" "0.000" "False" "82.874" "23" "10" "28" "8" "499" "56.3" "7.25" "92.69" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08332" "817" "ENSG00000145349" "CAMK2D" "A8MVS8; hsa:817; Q13557; Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9" "Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Signaling by BRAF and RAF1 fusions; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; SRF and miRs in smooth muscle differentiation and proliferation; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; ErbB signaling pathway" "33" "1" "0.954" "0.963" "0.888" "0.932" "0.937" "0.857" "0.878" "0.903" "0.954" "2200.8" "2098.5" "2118.9" "1953.8" "2051.4" "2061.4" "1885.8" "1932.4" "1987.1" "2099.5" "" "" "" "" "" "" "" "" "" "" "1767.7" "1514.2" "1683.1" "1309.0" "1418.8" "1546.6" "1320.3" "1411.3" "1987.1" "1707.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4915588766185396896" "False" "High" "IsMasterProtein" "Q86U44" "N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2" "0.000" "False" "82.843" "27" "11" "14" "11" "580" "64.4" "6.42" "58.66" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "56339" "ENSG00000165819" "METTL3" "hsa:56339; O14736; Q86U44; Q86V05; Q9HB32" "Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "2" "0" "1.018" "0.995" "0.979" "0.938" "1.023" "0.935" "0.945" "0.915" "0.976" "1148.9" "1169.1" "1143.7" "1125.2" "1077.1" "1174.9" "1074.6" "1085.3" "1051.3" "1121.5" "" "" "" "" "" "" "" "" "" "" "922.8" "843.6" "908.5" "753.9" "745.0" "881.5" "752.4" "792.6" "1051.3" "912.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2229585917492551052" "False" "High" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "0.000" "False" "82.822" "16" "16" "23" "15" "1094" "118.2" "7.06" "78.17" "16" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "1" "0.994" "0.970" "1.037" "1.041" "1.018" "0.996" "1.021" "1.005" "0.974" "1093.3" "1086.8" "1060.8" "1133.5" "1138.0" "1113.4" "1088.9" "1116.4" "1098.7" "1065.4" "" "" "" "" "" "" "" "" "" "" "878.2" "784.2" "842.6" "759.4" "787.0" "835.4" "762.4" "815.3" "1098.7" "866.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2214301499697937672" "False" "High" "IsMasterProtein" "Q96C86" "m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2" "0.000" "False" "82.793" "36" "12" "23" "12" "337" "38.6" "6.38" "81.76" "12" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05652, Pf11969" "28960" "ENSG00000110063" "DCPS" "hsa:28960; Q8NHL8; Q96C86; Q9Y2S5" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "0.941" "1.011" "0.883" "0.904" "0.906" "0.851" "0.938" "0.973" "0.933" "1927.5" "1814.3" "1948.6" "1702.3" "1742.7" "1746.4" "1639.8" "1807.1" "1875.4" "1797.9" "" "" "" "" "" "" "" "" "" "" "1548.1" "1309.1" "1547.8" "1140.6" "1205.3" "1310.3" "1148.1" "1319.8" "1875.4" "1462.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5965687288212214297" "False" "High" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "0.000" "False" "82.697" "33" "10" "18" "10" "374" "42.5" "5.63" "69.89" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "" "6" "0" "0.929" "0.994" "0.948" "0.992" "1.056" "0.986" "1.033" "0.978" "0.992" "1274.8" "1184.1" "1267.4" "1208.3" "1264.9" "1346.9" "1257.2" "1316.9" "1247.1" "1264.9" "" "" "" "" "" "" "" "" "" "" "1023.9" "854.4" "1006.7" "809.6" "874.8" "1010.5" "880.2" "961.7" "1247.1" "1028.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1311899877800093537" "False" "High" "IsMasterProtein" "Q9H0K6" "Pseudouridylate synthase PUS7L OS=Homo sapiens OX=9606 GN=PUS7L PE=1 SV=1" "0.000" "False" "82.659" "24" "17" "24" "17" "701" "80.6" "7.56" "76.66" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01142" "83448" "ENSG00000129317" "PUS7L" "B3KUJ1; hsa:83448; Q05CU0; Q6AHZ3; Q6NUP2; Q9H0K6" "" "" "0" "0" "1.017" "0.995" "0.986" "0.994" "0.984" "0.953" "0.997" "1.011" "1.032" "3087.6" "3140.7" "3073.6" "3045.9" "3067.7" "3038.9" "2943.9" "3079.1" "3122.5" "3187.1" "" "" "" "" "" "" "" "" "" "" "2479.9" "2266.2" "2441.5" "2040.8" "2121.6" "2280.1" "2061.2" "2248.7" "3122.5" "2591.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6570966043889327404" "False" "High" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "0.000" "False" "82.635" "22" "15" "22" "13" "767" "86.4" "6.89" "73.80" "15" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "" "Sterol regulatory element-binding proteins (SREBP) signaling" "1" "2" "1.023" "1.030" "1.003" "1.020" "1.018" "1.016" "1.041" "1.003" "1.019" "2006.3" "2053.0" "2065.7" "2012.3" "2046.9" "2042.8" "2037.5" "2087.6" "2011.8" "2044.2" "" "" "" "" "" "" "" "" "" "" "1611.4" "1481.4" "1640.8" "1348.2" "1415.7" "1532.7" "1426.5" "1524.6" "2011.8" "1662.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980650416735823729" "False" "High" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "0.000" "False" "82.613" "42" "13" "21" "13" "332" "37.5" "7.87" "77.91" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "0.939" "1.002" "0.942" "0.881" "0.943" "0.896" "0.878" "0.883" "0.922" "3379.8" "3172.4" "3384.9" "3183.2" "2976.7" "3188.6" "3029.1" "2968.4" "2983.5" "3116.0" "" "" "" "" "" "" "" "" "" "" "2714.6" "2289.1" "2688.8" "2132.7" "2058.7" "2392.4" "2120.8" "2167.8" "2983.5" "2534.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-933507358187812304" "False" "High" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "0.000" "False" "82.242" "8" "16" "17" "15" "2157" "228.7" "9.45" "60.68" "16" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "1.008" "1.100" "1.015" "1.106" "1.105" "1.102" "1.035" "1.052" "1.083" "1276.6" "1287.4" "1404.8" "1295.6" "1412.2" "1410.5" "1407.2" "1321.9" "1342.4" "1382.8" "" "" "" "" "" "" "" "" "" "" "1025.4" "928.9" "1115.8" "868.0" "976.7" "1058.3" "985.2" "965.4" "1342.4" "1124.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4858909322532710110" "False" "High" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "0.000" "False" "82.226" "25" "13" "25" "13" "649" "70.9" "7.39" "87.84" "13" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "PPARA activates gene expression; Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "16" "0" "0.964" "0.946" "0.982" "1.073" "1.018" "0.948" "0.932" "0.900" "0.947" "851.8" "821.5" "805.4" "836.2" "914.2" "866.9" "807.9" "794.2" "766.9" "806.3" "" "" "" "" "" "" "" "" "" "" "684.1" "592.7" "639.8" "560.2" "632.3" "650.4" "565.6" "580.0" "766.9" "655.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6205796797264401430" "False" "High" "IsMasterProtein" "Q96DH6" "RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1" "0.000" "False" "82.223" "28" "7" "16" "7" "328" "35.2" "8.48" "61.20" "7" "developmental processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "124540" "ENSG00000153944" "MSI2" "hsa:124540; Q7Z6M7; Q8N9T4; Q96DH6" "RHOBTB2 GTPase cycle" "" "1" "0" "1.037" "0.984" "0.985" "0.990" "0.939" "0.948" "0.983" "0.897" "0.977" "2088.2" "2165.2" "2053.8" "2057.5" "2066.8" "1960.1" "1978.6" "2053.0" "1874.1" "2039.7" "" "" "" "" "" "" "" "" "" "" "1677.2" "1562.3" "1631.4" "1378.5" "1429.4" "1470.6" "1385.3" "1499.3" "1874.1" "1658.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8219779968186532826" "False" "High" "IsMasterProtein" "Q9UI26" "Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1" "0.000" "False" "82.182" "17" "15" "23" "15" "975" "112.5" "5.25" "70.37" "15" "transport" "cytosol;nucleus" "other molecular function" "Pf03810" "51194" "ENSG00000086200" "IPO11" "A6NGJ5; B4DZ73; D3DW98; hsa:51194; Q8N5R2; Q9NSJ6; Q9NVB1; Q9UI26" "" "" "0" "0" "0.981" "0.951" "1.023" "1.007" "0.961" "0.979" "0.995" "0.950" "0.996" "1589.6" "1558.8" "1511.6" "1625.4" "1600.5" "1527.4" "1556.7" "1581.3" "1509.9" "1582.5" "" "" "" "" "" "" "" "" "" "" "1276.7" "1124.8" "1200.7" "1089.0" "1106.9" "1146.0" "1089.9" "1154.9" "1509.9" "1286.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-319216844392798796" "False" "High" "IsMasterProtein" "Q9Y4R8" "Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2" "0.000" "False" "82.099" "24" "19" "29" "19" "837" "91.7" "5.76" "82.82" "19" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10193" "9894" "ENSG00000100726" "TELO2" "D3DU73; hsa:9894; O75168; Q7LDV4; Q9BR21; Q9Y4R8" "" "Fragile X syndrome; Pleural mesothelioma" "2" "0" "1.095" "0.985" "1.051" "1.009" "1.023" "1.031" "1.043" "1.019" "1.037" "1748.9" "1915.7" "1722.7" "1838.8" "1764.2" "1789.3" "1803.7" "1824.5" "1781.4" "1813.9" "" "" "" "" "" "" "" "" "" "" "1404.7" "1382.3" "1368.4" "1232.0" "1220.2" "1342.5" "1262.9" "1332.4" "1781.4" "1475.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2093622632730469128" "False" "High" "IsMasterProtein" "Q15418" "Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens OX=9606 GN=RPS6KA1 PE=1 SV=2" "0.000" "False" "82.048" "24" "19" "24" "11" "735" "82.7" "7.83" "78.34" "19" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6195" "ENSG00000117676; ENSG00000281877" "RPS6KA1" "A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4; hsa:6195; Q15418; Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2" "Recycling pathway of L1; Senescence-Associated Secretory Phenotype (SASP); RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; TYROBP causal network in microglia; Thermogenesis; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map" "26" "6" "1.002" "0.983" "0.963" "1.002" "0.973" "0.923" "0.992" "0.995" "0.988" "2283.4" "2287.0" "2244.6" "2198.3" "2288.2" "2222.3" "2107.0" "2265.8" "2272.0" "2257.1" "" "" "" "" "" "" "" "" "" "" "1834.0" "1650.3" "1783.0" "1472.9" "1582.5" "1667.3" "1475.2" "1654.7" "2272.0" "1835.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658594625945977388" "False" "High" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "0.000" "False" "82.025" "25" "17" "27" "16" "706" "79.9" "6.68" "85.27" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "9" "1" "1.018" "1.001" "1.056" "1.024" "1.016" "1.056" "1.053" "1.038" "1.017" "2566.2" "2612.5" "2568.6" "2709.6" "2628.9" "2607.3" "2710.6" "2703.4" "2663.6" "2608.7" "" "" "" "" "" "" "" "" "" "" "2061.1" "1885.1" "2040.3" "1815.5" "1818.2" "1956.2" "1897.8" "1974.3" "2663.6" "2121.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926679715344885449" "False" "High" "IsMasterProtein" "O94913" "Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3" "0.000" "False" "81.902" "13" "18" "19" "18" "1555" "172.9" "8.48" "70.91" "18" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04818, Pf11526, Pf20827, Pf20844, Pf20845" "51585" "ENSG00000165494" "PCF11" "A6H8W7; hsa:51585; O43671; O94913; Q6P0X8" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs" "" "5" "0" "0.982" "0.993" "1.033" "1.097" "1.054" "1.020" "1.036" "1.059" "1.035" "2154.8" "2115.9" "2140.5" "2225.8" "2363.3" "2270.8" "2197.0" "2232.2" "2282.5" "2230.1" "" "" "" "" "" "" "" "" "" "" "1730.7" "1526.7" "1700.3" "1491.3" "1634.5" "1703.7" "1538.2" "1630.2" "2282.5" "1813.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073830227573610312" "False" "High" "IsMasterProtein" "Q9NR45" "Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2" "0.000" "False" "81.823" "38" "10" "21" "10" "359" "40.3" "6.74" "86.51" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03102, Pf08666" "54187" "ENSG00000095380" "NANS" "B2RE98; Q8WUV9; Q9BWS6; Q9NR45; Q9NVD4" "Sialic acid metabolism" "Sialylation" "2" "0" "0.959" "0.986" "0.943" "0.947" "1.007" "0.925" "0.921" "0.955" "0.940" "2404.7" "2305.1" "2370.7" "2267.3" "2276.6" "2421.9" "2223.7" "2213.7" "2296.6" "2260.5" "" "" "" "" "" "" "" "" "" "" "1931.4" "1663.3" "1883.1" "1519.1" "1574.5" "1817.1" "1556.9" "1616.7" "2296.6" "1838.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415570283207223737" "False" "High" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "0.000" "False" "81.812" "41" "12" "18" "12" "329" "35.2" "8.44" "63.73" "12" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "0.990" "1.004" "0.988" "0.971" "1.027" "0.997" "1.005" "0.956" "0.973" "1208.4" "1196.1" "1213.0" "1194.3" "1173.4" "1240.8" "1204.2" "1214.7" "1155.6" "1175.9" "" "" "" "" "" "" "" "" "" "" "970.5" "863.1" "963.5" "800.2" "811.5" "931.0" "843.1" "887.1" "1155.6" "956.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4076214252454433299" "False" "High" "IsMasterProtein" "Q969G3" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2" "0.000" "False" "81.613" "35" "13" "22" "13" "411" "46.6" "4.88" "75.72" "13" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6605" "ENSG00000073584" "SMARCE1" "B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6; hsa:6605; O43539; Q969G3" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis" "6" "0" "1.068" "1.067" "1.063" "1.029" "1.025" "1.050" "1.084" "1.047" "1.038" "2163.5" "2309.6" "2308.2" "2300.1" "2226.9" "2218.6" "2271.3" "2344.7" "2266.0" "2245.0" "" "" "" "" "" "" "" "" "" "" "1737.7" "1666.6" "1833.5" "1541.1" "1540.2" "1664.6" "1590.2" "1712.3" "2266.0" "1825.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980500697727064305" "False" "High" "IsMasterProtein" "O43815" "Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4" "0.000" "False" "81.571" "21" "12" "15" "12" "780" "86.1" "5.27" "62.02" "12" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400, Pf08232" "6801" "ENSG00000115808" "STRN" "hsa:6801; O43815; Q3KP65; Q53TQ8; Q9NP38" "Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "MET in type 1 papillary renal cell carcinoma" "8" "0" "1.038" "1.012" "1.076" "1.084" "1.037" "1.066" "1.062" "1.079" "1.081" "1538.2" "1597.0" "1556.8" "1655.6" "1666.7" "1595.1" "1640.2" "1633.7" "1660.4" "1663.4" "" "" "" "" "" "" "" "" "" "" "1235.5" "1152.3" "1236.6" "1109.2" "1152.7" "1196.8" "1148.3" "1193.1" "1660.4" "1352.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468856902780976606" "False" "High" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "0.000" "False" "81.516" "28" "9" "17" "9" "412" "45.7" "6.48" "60.62" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "" "1" "0" "1.026" "0.994" "0.973" "0.921" "0.917" "0.924" "0.961" "0.922" "0.882" "1205.7" "1236.5" "1198.8" "1172.6" "1110.4" "1105.7" "1114.1" "1158.8" "1111.1" "1063.7" "" "" "" "" "" "" "" "" "" "" "968.4" "892.2" "952.2" "785.6" "768.0" "829.6" "780.0" "846.2" "1111.1" "865.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839612719642205858" "False" "High" "IsMasterProtein" "P09417" "Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2" "0.000" "False" "81.497" "54" "9" "20" "9" "244" "25.8" "7.37" "84.54" "9" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00106" "5860" "ENSG00000151552" "QDPR" "A8K158; B3KW71; hsa:5860; P09417; Q53F52; Q9H3M5" "Phenylalanine metabolism" "" "1" "0" "0.938" "0.971" "0.990" "0.965" "0.951" "0.933" "0.904" "0.941" "0.939" "1547.7" "1451.8" "1503.3" "1532.9" "1492.8" "1472.6" "1443.7" "1399.3" "1456.7" "1452.9" "" "" "" "" "" "" "" "" "" "" "1243.1" "1047.6" "1194.1" "1027.1" "1032.4" "1104.8" "1010.8" "1021.9" "1456.7" "1181.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2081784358139501247" "False" "High" "IsMasterProtein" "Q96ME1" "F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18 PE=1 SV=3" "0.000" "False" "81.289" "24" "13" "17" "13" "718" "78.9" "8.27" "55.43" "13" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937, Pf19729" "80028" "ENSG00000155034" "FBXL18" "A0A024R857; B3KTC9; B4DH63; H0Y6I6; hsa:80028; Q96ME1; Q9BR90; Q9BTC7; Q9HAK7" "Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation" "" "3" "0" "1.008" "1.032" "1.080" "0.986" "1.046" "0.997" "0.959" "1.011" "1.027" "659.3" "664.8" "680.6" "711.7" "650.0" "689.3" "657.5" "632.2" "666.3" "677.3" "" "" "" "" "" "" "" "" "" "" "529.5" "479.7" "540.6" "476.9" "449.5" "517.2" "460.4" "461.7" "666.3" "550.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3678214923131327318" "False" "High" "IsMasterProtein" "Q96RQ3" "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC1 PE=1 SV=3" "0.000" "False" "81.247" "22" "10" "13" "10" "725" "80.4" "7.78" "61.22" "10" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786" "56922" "ENSG00000078070" "MCCC1" "hsa:56922; Q59ES4; Q96RQ3; Q9H959; Q9NS97" "Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "Amino acid metabolism" "4" "0" "1.011" "0.965" "1.088" "0.958" "0.938" "0.958" "0.970" "0.946" "0.987" "963.1" "973.5" "929.2" "1047.4" "923.0" "903.8" "923.0" "934.6" "911.3" "950.3" "" "" "" "" "" "" "" "" "" "" "773.5" "702.5" "738.1" "701.7" "638.3" "678.1" "646.2" "682.5" "911.3" "772.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980690536672084448" "False" "High" "IsMasterProtein" "Q8NHV4" "Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1" "0.000" "False" "81.238" "25" "13" "20" "13" "660" "71.9" "7.97" "69.39" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "121441" "ENSG00000139350" "NEDD1" "B0AZN0; B4E145; G3V3F1; hsa:121441; Q8NA30; Q8NHV4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.021" "0.973" "1.049" "1.058" "1.039" "1.060" "1.083" "1.081" "1.050" "1896.5" "1936.0" "1846.0" "1989.5" "2007.2" "1971.4" "2011.2" "2053.6" "2049.3" "1992.2" "" "" "" "" "" "" "" "" "" "" "1523.2" "1396.9" "1466.4" "1332.9" "1388.2" "1479.1" "1408.1" "1499.8" "2049.3" "1620.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1619484696952214884" "False" "High" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "0.000" "False" "81.167" "44" "9" "33" "7" "225" "24.7" "4.67" "114.88" "9" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Eukaryotic Translation Elongation" "Translation factors" "2" "0" "0.958" "0.985" "0.865" "0.914" "0.951" "0.913" "0.958" "0.931" "0.914" "2226.2" "2133.6" "2192.9" "1925.5" "2033.8" "2118.1" "2032.4" "2133.3" "2073.6" "2035.0" "" "" "" "" "" "" "" "" "" "" "1788.1" "1539.6" "1741.9" "1290.1" "1406.6" "1589.2" "1423.0" "1557.9" "2073.6" "1655.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2086395098636375665" "False" "High" "IsMasterProtein" "Q96Q89" "Kinesin-like protein KIF20B OS=Homo sapiens OX=9606 GN=KIF20B PE=1 SV=3" "0.000" "False" "81.043" "10" "19" "21" "19" "1820" "210.5" "5.67" "69.92" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9585" "ENSG00000138182" "KIF20B" "A8MXM7; hsa:9585; O43277; Q09471; Q2KQ73; Q32NE1; Q561V3; Q58EX8; Q5T9M8; Q5T9M9; Q5T9N0; Q5T9N1; Q7KZ68; Q7Z5E0; Q7Z5E1; Q7Z6M9; Q86X82; Q96Q89; Q9H3R8; Q9H6Q9; Q9H755; Q9NTC1; Q9UFR5" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "Gastric cancer network 1" "3" "0" "1.047" "1.045" "1.035" "1.033" "0.989" "0.990" "1.057" "0.994" "1.021" "1668.5" "1746.1" "1744.3" "1726.6" "1723.9" "1649.7" "1652.0" "1764.1" "1658.3" "1703.9" "" "" "" "" "" "" "" "" "" "" "1340.1" "1260.0" "1385.6" "1156.8" "1192.3" "1237.8" "1156.7" "1288.3" "1658.3" "1385.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5104868076877432039" "False" "High" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "0.000" "False" "81.042" "40" "12" "24" "12" "313" "34.8" "5.60" "88.57" "12" "" "mitochondrion" "" "Pf21207, Pf21701" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "0.971" "0.973" "0.953" "1.013" "0.979" "0.979" "0.953" "0.959" "0.960" "3601.6" "3498.5" "3502.6" "3434.1" "3649.1" "3525.0" "3524.5" "3433.8" "3454.4" "3456.9" "" "" "" "" "" "" "" "" "" "" "2892.8" "2524.4" "2782.3" "2300.9" "2523.8" "2644.8" "2467.7" "2507.7" "3454.4" "2811.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1310996743308863221" "False" "High" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "0.000" "False" "81.024" "51" "16" "25" "16" "250" "28.7" "8.75" "80.15" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; Q96FX0; Q9NV53; Q9Y3A5" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "0.955" "1.005" "0.893" "0.907" "0.967" "0.927" "0.913" "0.941" "0.928" "2877.7" "2748.7" "2890.9" "2568.9" "2610.0" "2784.0" "2666.6" "2628.5" "2708.6" "2669.7" "" "" "" "" "" "" "" "" "" "" "2311.3" "1983.4" "2296.3" "1721.2" "1805.1" "2088.8" "1867.0" "1919.6" "2708.6" "2171.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106198041571123129" "False" "High" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "0.000" "False" "81.016" "27" "11" "24" "11" "504" "55.1" "6.61" "83.01" "11" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "Q9UMS4" "mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex" "" "5" "0" "0.980" "1.051" "0.984" "0.993" "0.971" "0.938" "0.996" "0.968" "1.008" "3309.5" "3242.7" "3477.2" "3255.9" "3287.9" "3212.3" "3104.8" "3296.4" "3202.9" "3335.5" "" "" "" "" "" "" "" "" "" "" "2658.1" "2339.8" "2762.1" "2181.5" "2273.9" "2410.2" "2173.8" "2407.3" "3202.9" "2712.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "934468542703033965" "False" "High" "IsMasterProtein" "Q15477" "Superkiller complex protein 2 OS=Homo sapiens OX=9606 GN=SKIC2 PE=1 SV=3" "0.000" "False" "80.996" "17" "19" "23" "19" "1246" "137.7" "6.06" "73.50" "19" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf17911, Pf21408" "6499" "ENSG00000204351; ENSG00000206353; ENSG00000223493; ENSG00000225737; ENSG00000228896; ENSG00000232616" "SKIC2" "hsa:6499; O15005; Q12902; Q15476; Q15477; Q5ST66" "Association of TriC/CCT with target proteins during biosynthesis; mRNA decay by 3' to 5' exoribonuclease" "" "2" "0" "0.993" "1.010" "0.979" "0.966" "0.977" "0.946" "0.953" "0.941" "1.000" "2487.1" "2469.5" "2511.4" "2434.2" "2403.2" "2429.2" "2352.5" "2369.3" "2340.3" "2485.9" "" "" "" "" "" "" "" "" "" "" "1997.6" "1781.9" "1994.9" "1630.9" "1662.1" "1822.6" "1647.1" "1730.3" "2340.3" "2021.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2041332710814858625" "False" "High" "IsMasterProtein" "Q9NRY4" "Rho GTPase-activating protein 35 OS=Homo sapiens OX=9606 GN=ARHGAP35 PE=1 SV=3" "0.000" "False" "80.978" "12" "14" "17" "14" "1499" "170.4" "6.64" "60.44" "14" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00071, Pf00620, Pf16512, Pf19518" "2909" "ENSG00000160007" "ARHGAP35" "A7E2A4; hsa:2909; Q14452; Q9C0E1; Q9NRY4" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOC GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Sema4D mediated inhibition of cell attachment and migration; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "Focal adhesion; Regulation of actin cytoskeleton" "18" "0" "0.995" "0.974" "0.982" "0.987" "1.003" "0.972" "1.005" "1.052" "1.040" "1776.1" "1767.1" "1730.2" "1743.4" "1753.2" "1780.6" "1725.8" "1784.5" "1867.7" "1847.8" "" "" "" "" "" "" "" "" "" "" "1426.5" "1275.1" "1374.3" "1168.1" "1212.6" "1336.0" "1208.3" "1303.2" "1867.7" "1502.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4884717818161655002" "False" "High" "IsMasterProtein" "Q9H4L5" "Oxysterol-binding protein-related protein 3 OS=Homo sapiens OX=9606 GN=OSBPL3 PE=1 SV=1" "0.000" "False" "80.945" "18" "12" "19" "12" "887" "101.2" "6.87" "64.72" "12" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "26031" "ENSG00000070882" "OSBPL3" "A4D167; A4D168; A4D169; A4D170; A4D171; A4D172; B8ZZ79; B8ZZP0; hsa:26031; O14591; O43357; O43358; Q8N702; Q8N703; Q8N704; Q8NFH0; Q8NFH1; Q8NI12; Q8NI13; Q9BZF4; Q9H4L5; Q9UED6" "Synthesis of bile acids and bile salts" "Orexin receptor pathway" "2" "0" "1.036" "0.983" "0.968" "1.037" "0.999" "1.006" "1.006" "1.069" "1.040" "1198.7" "1241.9" "1178.8" "1160.1" "1242.8" "1197.7" "1205.8" "1205.6" "1282.0" "1246.2" "" "" "" "" "" "" "" "" "" "" "962.8" "896.2" "936.4" "777.2" "859.5" "898.6" "844.2" "880.4" "1282.0" "1013.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3443446084982214279" "False" "High" "IsMasterProtein" "Q9UN37" "Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1" "0.000" "False" "80.668" "37" "16" "27" "12" "437" "48.9" "7.80" "88.45" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "27183" "ENSG00000132612" "VPS4A" "B2RCB7; hsa:27183; Q8TF07; Q9UI03; Q9UN37; Q9Y582" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III" "Ebola virus infection in host; Ciliary landscape" "6" "0" "0.995" "0.984" "1.020" "1.042" "1.023" "1.056" "1.036" "1.052" "1.050" "1574.4" "1566.2" "1549.1" "1605.7" "1640.7" "1610.9" "1662.8" "1630.3" "1656.7" "1653.8" "" "" "" "" "" "" "" "" "" "" "1264.5" "1130.1" "1230.5" "1075.9" "1134.7" "1208.6" "1164.2" "1190.6" "1656.7" "1344.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669243048092869257" "False" "High" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "0.000" "False" "80.530" "42" "17" "29" "17" "426" "48.6" "5.31" "100.98" "17" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "Protein hydroxylation" "VEGFA-VEGFR2 signaling" "2" "0" "1.060" "1.059" "1.041" "1.042" "1.078" "1.038" "1.095" "1.052" "1.041" "3016.9" "3198.5" "3193.8" "3139.5" "3144.3" "3252.2" "3132.9" "3305.0" "3175.2" "3141.4" "" "" "" "" "" "" "" "" "" "" "2423.2" "2308.0" "2537.0" "2103.5" "2174.6" "2440.0" "2193.5" "2413.7" "3175.2" "2554.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3546401136209877532" "False" "High" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "0.000" "False" "80.515" "50" "13" "27" "13" "320" "35.6" "6.13" "86.12" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.997" "0.998" "1.053" "1.062" "1.017" "1.059" "1.021" "1.029" "1.017" "1582.2" "1578.3" "1579.5" "1666.3" "1680.1" "1608.8" "1676.3" "1615.5" "1627.9" "1608.7" "" "" "" "" "" "" "" "" "" "" "1270.8" "1138.8" "1254.7" "1116.4" "1162.0" "1207.0" "1173.7" "1179.8" "1627.9" "1308.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200158126373336546" "False" "High" "IsMasterProtein" "Q6IBS0" "Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2" "0.000" "False" "80.442" "48" "13" "19" "10" "349" "39.5" "6.84" "70.63" "13" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "11344" "ENSG00000247596" "TWF2" "hsa:11344; Q6IBS0; Q9Y3F5" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "0.930" "0.985" "0.898" "0.914" "0.939" "0.914" "0.910" "0.901" "0.942" "1574.2" "1464.5" "1551.3" "1413.5" "1439.5" "1478.7" "1439.3" "1433.0" "1417.7" "1483.5" "" "" "" "" "" "" "" "" "" "" "1264.4" "1056.7" "1232.3" "947.0" "995.6" "1109.4" "1007.7" "1046.5" "1417.7" "1206.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1852571755298916304" "False" "High" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "0.000" "False" "80.371" "37" "14" "21" "14" "468" "50.1" "7.06" "74.75" "14" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "1.030" "1.021" "1.014" "1.049" "1.079" "1.070" "1.034" "1.094" "1.063" "1902.1" "1959.3" "1941.4" "1927.9" "1995.3" "2053.0" "2035.0" "1967.0" "2080.2" "2021.9" "" "" "" "" "" "" "" "" "" "" "1527.7" "1413.8" "1542.1" "1291.7" "1380.0" "1540.3" "1424.8" "1436.5" "2080.2" "1644.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219195248541824635" "False" "High" "IsMasterProtein" "Q92609" "TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1" "0.000" "False" "80.175" "14" "9" "19" "9" "795" "88.9" "6.54" "65.44" "9" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9779" "ENSG00000131374" "TBC1D5" "A6NP25; C9JP52; hsa:9779; Q92609" "" "" "0" "0" "0.999" "0.993" "0.967" "0.980" "0.971" "0.919" "0.961" "0.958" "0.979" "1422.2" "1421.3" "1412.8" "1374.9" "1394.0" "1380.6" "1307.2" "1366.7" "1362.0" "1392.9" "" "" "" "" "" "" "" "" "" "" "1142.3" "1025.6" "1122.2" "921.2" "964.1" "1035.9" "915.3" "998.1" "1362.0" "1132.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141032543915842811" "False" "High" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "0.000" "False" "79.905" "34" "9" "29" "9" "328" "35.8" "8.00" "94.60" "9" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Peroxisomal protein import; Mitochondrial protein degradation" "Fatty acid biosynthesis; IL-18 signaling pathway" "4" "0" "0.956" "0.984" "0.930" "0.960" "0.975" "0.941" "0.910" "0.922" "0.925" "2895.5" "2769.3" "2850.6" "2691.7" "2778.7" "2823.9" "2723.4" "2635.3" "2669.7" "2679.5" "" "" "" "" "" "" "" "" "" "" "2325.7" "1998.2" "2264.3" "1803.4" "1921.7" "2118.7" "1906.8" "1924.6" "2669.7" "2179.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7197122219504261731" "False" "High" "IsMasterProtein" "Q96EK9" "Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1" "0.000" "False" "79.892" "35" "9" "17" "9" "354" "38.6" "6.95" "76.05" "9" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf08433" "112970" "ENSG00000198841" "KTI12" "hsa:112970; Q96EK9" "" "" "0" "0" "1.018" "1.018" "1.059" "1.003" "0.989" "1.031" "1.008" "1.017" "1.023" "1710.5" "1741.5" "1741.9" "1811.4" "1716.3" "1691.7" "1763.3" "1724.8" "1739.6" "1749.4" "" "" "" "" "" "" "" "" "" "" "1373.9" "1256.6" "1383.7" "1213.6" "1187.0" "1269.3" "1234.6" "1259.6" "1739.6" "1422.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939378456610215612" "False" "High" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "0.000" "False" "79.889" "14" "16" "20" "12" "1239" "142.0" "7.46" "60.55" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "Oxidative Stress Induced Senescence" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "7" "3" "1.071" "1.069" "1.060" "1.028" "1.015" "1.083" "1.045" "1.046" "1.038" "827.6" "886.3" "885.1" "877.2" "851.1" "840.3" "896.2" "864.6" "866.0" "858.8" "" "" "" "" "" "" "" "" "" "" "664.7" "639.5" "703.1" "587.7" "588.6" "630.4" "627.4" "631.4" "866.0" "698.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5309458315612800198" "False" "High" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "0.000" "False" "79.884" "24" "11" "16" "11" "669" "72.4" "8.34" "62.34" "11" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "1.030" "1.011" "1.062" "1.046" "0.973" "0.979" "1.014" "0.964" "0.986" "1168.1" "1202.9" "1180.7" "1240.6" "1222.1" "1137.1" "1143.6" "1184.2" "1126.5" "1152.1" "" "" "" "" "" "" "" "" "" "" "938.2" "867.9" "937.9" "831.2" "845.2" "853.1" "800.7" "864.8" "1126.5" "937.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888826320597161834" "False" "High" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "0.000" "False" "79.779" "25" "12" "30" "12" "551" "59.2" "7.15" "93.54" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "2" "0" "0.945" "0.995" "1.118" "1.206" "1.127" "1.190" "1.155" "1.204" "1.130" "2173.5" "2053.9" "2162.2" "2429.6" "2621.7" "2450.6" "2586.8" "2509.7" "2616.3" "2456.5" "" "" "" "" "" "" "" "" "" "" "1745.8" "1482.1" "1717.5" "1627.8" "1813.2" "1838.6" "1811.1" "1832.9" "2616.3" "1997.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3689472973843486022" "False" "High" "IsMasterProtein" "O00505" "Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2" "0.000" "False" "79.779" "20" "10" "22" "5" "521" "57.8" "4.94" "73.50" "10" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3839" "ENSG00000102753" "KPNA3" "hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "" "2" "0" "1.003" "1.039" "0.980" "0.933" "0.932" "0.896" "1.018" "1.006" "0.925" "1405.1" "1410.0" "1460.4" "1376.9" "1311.5" "1310.0" "1259.5" "1430.2" "1413.8" "1299.6" "" "" "" "" "" "" "" "" "" "" "1128.6" "1017.4" "1160.0" "922.5" "907.0" "982.9" "881.9" "1044.5" "1413.8" "1056.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1723896581553543701" "False" "High" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "0.000" "False" "79.717" "20" "10" "41" "9" "443" "48.2" "8.66" "149.09" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "PTK6 Regulates Proteins Involved in RNA Processing" "Leptin signaling pathway; Primary ovarian insufficiency" "3" "0" "1.008" "1.041" "1.001" "1.000" "1.050" "1.006" "1.000" "1.055" "1.015" "3201.8" "3227.2" "3332.4" "3205.5" "3201.1" "3361.1" "3221.1" "3202.9" "3376.8" "3249.8" "" "" "" "" "" "" "" "" "" "" "2571.7" "2328.6" "2647.0" "2147.7" "2213.9" "2521.7" "2255.3" "2339.1" "3376.8" "2642.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181785604482644820" "False" "High" "IsMasterProtein" "Q9NR50" "Translation initiation factor eIF2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1" "0.000" "False" "79.649" "38" "13" "22" "13" "452" "50.2" "6.47" "67.79" "13" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00483" "8891" "ENSG00000070785" "EIF2B3" "B2RBH8; D3DPZ2; hsa:8891; Q5QP89; Q5QP90; Q8NDB5; Q8WV57; Q9H850; Q9NR50" "Recycling of eIF2:GDP" "Translation factors; Primary ovarian insufficiency" "3" "0" "1.029" "1.024" "1.006" "0.966" "0.954" "0.956" "0.978" "0.977" "0.974" "2144.8" "2206.8" "2196.6" "2157.6" "2071.5" "2046.5" "2050.0" "2098.4" "2095.5" "2089.3" "" "" "" "" "" "" "" "" "" "" "1722.7" "1592.4" "1744.9" "1445.6" "1432.7" "1535.5" "1435.3" "1532.5" "2095.5" "1699.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3146791204946970239" "False" "High" "IsMasterProtein" "Q9Y6W5" "Actin-binding protein WASF2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "0.000" "False" "79.633" "26" "14" "22" "14" "498" "54.3" "5.53" "79.97" "14" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "Regulation of actin dynamics for phagocytic cup formation; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "Regulation of actin cytoskeleton" "8" "0" "0.997" "1.005" "1.065" "1.008" "0.944" "1.003" "0.916" "0.988" "0.976" "2266.1" "2260.2" "2278.3" "2414.2" "2283.5" "2139.7" "2272.7" "2074.9" "2239.0" "2211.3" "" "" "" "" "" "" "" "" "" "" "1820.1" "1630.9" "1809.7" "1617.5" "1579.3" "1605.4" "1591.2" "1515.3" "2239.0" "1798.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851715051474233643" "False" "High" "IsMasterProtein" "Q9P2A4" "ABI gene family member 3 OS=Homo sapiens OX=9606 GN=ABI3 PE=1 SV=2" "0.000" "False" "79.570" "33" "11" "19" "11" "366" "39.0" "5.08" "68.56" "11" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "cytoskeletal activity;other molecular function" "Pf07815, Pf14604" "51225" "ENSG00000108798" "ABI3" "C9IZN8; hsa:51225; Q9H0P6; Q9P2A4" "" "" "0" "0" "1.010" "1.051" "1.034" "1.034" "1.041" "0.951" "1.028" "1.072" "1.040" "1472.9" "1487.8" "1548.6" "1523.4" "1523.1" "1532.9" "1400.7" "1514.3" "1578.5" "1531.4" "" "" "" "" "" "" "" "" "" "" "1183.0" "1073.6" "1230.1" "1020.7" "1053.4" "1150.1" "980.7" "1105.9" "1578.5" "1245.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4709536422529614216" "False" "High" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "0.000" "False" "79.519" "56" "11" "24" "11" "241" "26.5" "8.13" "89.98" "11" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "0.974" "0.979" "0.898" "1.014" "1.030" "0.990" "1.040" "0.998" "1.022" "1379.0" "1342.9" "1349.5" "1238.3" "1398.3" "1420.3" "1365.6" "1434.8" "1376.5" "1409.4" "" "" "" "" "" "" "" "" "" "" "1107.6" "969.0" "1071.9" "829.7" "967.1" "1065.6" "956.2" "1047.8" "1376.5" "1146.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7033934706938727348" "False" "High" "IsMasterProtein" "Q9UNY4" "Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2" "0.000" "False" "79.373" "18" "19" "21" "19" "1162" "129.5" "8.37" "70.90" "19" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf06839" "8458" "ENSG00000116830" "TTF2" "A8K4Q2; hsa:8458; O75921; Q5T2K7; Q5VVU8; Q8N6I8; Q9UNY4" "" "Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "2" "0" "1.051" "1.023" "1.011" "0.987" "0.962" "1.088" "1.194" "1.173" "1.079" "1591.5" "1672.6" "1628.4" "1609.7" "1570.5" "1531.4" "1730.9" "1899.8" "1866.5" "1716.8" "" "" "" "" "" "" "" "" "" "" "1278.3" "1206.9" "1293.5" "1078.5" "1086.2" "1149.0" "1211.9" "1387.4" "1866.5" "1396.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5656635003875974689" "False" "High" "IsMasterProtein" "Q13111" "Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3" "0.000" "False" "79.356" "18" "17" "24" "17" "956" "106.8" "5.94" "84.87" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf11600, Pf12253, Pf15539, Pf15557" "10036" "ENSG00000167670" "CHAF1A" "hsa:10036; Q13111; Q6NXG5; Q7Z7K3; Q9UJY8" "" "Nanoparticle triggered autophagic cell death" "1" "0" "0.992" "0.982" "1.042" "1.007" "1.027" "1.151" "1.141" "1.156" "1.065" "1966.1" "1949.6" "1929.9" "2047.9" "1979.5" "2019.8" "2263.0" "2243.6" "2272.2" "2093.3" "" "" "" "" "" "" "" "" "" "" "1579.2" "1406.7" "1533.0" "1372.1" "1369.1" "1515.4" "1584.4" "1638.5" "2272.2" "1702.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6983483800967602038" "False" "High" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "0.000" "False" "79.317" "28" "19" "27" "19" "706" "80.2" "6.70" "80.29" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.004" "0.955" "0.985" "0.972" "0.986" "1.014" "1.037" "0.965" "0.980" "1794.4" "1802.1" "1713.7" "1768.3" "1744.7" "1768.6" "1820.3" "1860.6" "1732.1" "1757.6" "" "" "" "" "" "" "" "" "" "" "1441.2" "1300.3" "1361.3" "1184.8" "1206.6" "1326.9" "1274.5" "1358.8" "1732.1" "1429.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3934264021141742446" "False" "High" "IsMasterProtein" "Q9UI12" "V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1" "0.000" "False" "79.227" "41" "15" "24" "15" "483" "55.8" "6.48" "73.66" "15" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity;enzyme regulator activity" "Pf03224, Pf11698" "51606" "ENSG00000047249" "ATP6V1H" "B3KMR0; hsa:51606; Q6PK44; Q9H3E3; Q9UI12; Q9Y300" "Nef Mediated CD4 Down-regulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; Nef Mediated CD8 Down-regulation; Blockage of phagosome acidification" "Proximal tubule transport" "9" "0" "0.967" "0.988" "0.937" "0.940" "0.937" "0.916" "0.911" "0.942" "0.930" "2114.3" "2044.4" "2088.8" "1982.1" "1987.7" "1981.5" "1937.4" "1926.4" "1991.8" "1966.1" "" "" "" "" "" "" "" "" "" "" "1698.2" "1475.2" "1659.2" "1328.0" "1374.7" "1486.7" "1356.4" "1406.8" "1991.8" "1598.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2273417600798469774" "False" "High" "IsMasterProtein" "Q10570" "Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2" "0.000" "False" "79.212" "13" "17" "22" "17" "1443" "160.8" "6.40" "73.59" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "29894" "ENSG00000071894; ENSG00000285049" "CPSF1" "hsa:29894; Q10570; Q96AF0" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "7" "0" "0.985" "1.004" "1.021" "1.129" "1.096" "1.083" "1.067" "1.082" "1.060" "969.8" "954.9" "973.8" "990.2" "1095.3" "1062.6" "1049.9" "1034.7" "1049.7" "1028.1" "" "" "" "" "" "" "" "" "" "" "778.9" "689.0" "773.5" "663.4" "757.5" "797.3" "735.1" "755.6" "1049.7" "836.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7919502417942593637" "False" "High" "IsMasterProtein" "A5A3E0" "POTE ankyrin domain family member F OS=Homo sapiens OX=9606 GN=POTEF PE=1 SV=2" "0.000" "False" "79.182" "8" "8" "233" "1" "1075" "121.4" "6.20" "658.90" "8" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022, Pf12796, Pf14915" "728378" "ENSG00000196604" "POTEF" "A5A3E0; A6NC34; hsa:728378" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406338825216404645" "False" "High" "IsMasterProtein" "Q16740" "ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1" "0.000" "False" "79.003" "42" "9" "28" "9" "277" "30.2" "8.09" "85.21" "9" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00574" "8192" "ENSG00000125656" "CLPP" "B2R4W5; hsa:8192; Q16740" "Mitochondrial protein degradation" "Primary ovarian insufficiency" "2" "0" "0.977" "0.970" "0.948" "1.013" "1.014" "0.916" "0.963" "1.019" "0.961" "2028.9" "1981.3" "1968.5" "1923.6" "2055.4" "2056.7" "1858.3" "1953.7" "2067.4" "1948.9" "" "" "" "" "" "" "" "" "" "" "1629.6" "1429.6" "1563.6" "1288.8" "1421.5" "1543.1" "1301.1" "1426.8" "2067.4" "1584.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651766820472939276" "False" "High" "IsMasterProtein" "Q12792" "Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3" "0.000" "False" "79.002" "49" "15" "23" "12" "350" "40.3" "6.96" "77.55" "15" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "5756" "ENSG00000151239" "TWF1" "A8K5A8; B3KXS6; B4DLX9; hsa:5756; Q12792; Q59G07; Q5U0B1; Q6FHJ1; Q6FHL6; Q6NUK9; Q86XL6; Q8TCD3" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle" "" "3" "2" "0.971" "0.975" "0.930" "0.920" "0.961" "0.956" "0.944" "0.953" "0.961" "1753.8" "1703.5" "1709.3" "1631.2" "1613.2" "1684.8" "1676.1" "1654.8" "1671.6" "1685.6" "" "" "" "" "" "" "" "" "" "" "1408.6" "1229.2" "1357.7" "1092.9" "1115.7" "1264.1" "1173.6" "1208.5" "1671.6" "1370.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357648313694038384" "False" "High" "IsMasterProtein" "Q8IUD2" "ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1" "0.000" "False" "78.986" "15" "15" "17" "15" "1116" "128.0" "5.97" "58.39" "15" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf09457, Pf10174" "23085" "ENSG00000082805" "ERC1" "A2RU77; A7E295; D3DUP7; D3DUP8; hsa:23085; Q6NVK2; Q8IUD2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; Q9UPS1" "" "Cell lineage map for neuronal differentiation" "1" "0" "0.978" "0.956" "1.007" "1.014" "1.002" "1.010" "0.963" "0.982" "1.003" "1146.8" "1121.1" "1096.7" "1154.3" "1162.6" "1149.3" "1157.9" "1104.3" "1126.5" "1150.1" "" "" "" "" "" "" "" "" "" "" "921.1" "809.0" "871.2" "773.4" "804.1" "862.3" "810.7" "806.5" "1126.5" "935.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4921032794514216116" "False" "High" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "0.000" "False" "78.982" "53" "11" "20" "11" "260" "29.9" "5.73" "79.39" "11" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "1.085" "1.204" "0.962" "0.870" "0.858" "1.011" "1.143" "1.166" "1.032" "1392.4" "1510.9" "1676.5" "1340.2" "1210.9" "1194.4" "1407.8" "1591.2" "1624.0" "1437.6" "" "" "" "" "" "" "" "" "" "" "1118.4" "1090.2" "1331.7" "897.9" "837.5" "896.2" "985.7" "1162.1" "1624.0" "1169.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857902194460077614" "False" "High" "IsMasterProtein" "Q13535" "Serine/threonine-protein kinase ATR OS=Homo sapiens OX=9606 GN=ATR PE=1 SV=3" "0.000" "False" "78.895" "8" "19" "22" "19" "2644" "301.2" "7.43" "69.27" "19" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08064" "545" "ENSG00000175054" "ATR" "hsa:545; Q13535; Q59HB2; Q7KYL3; Q93051; Q9BXK4" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic synapsis; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; Cell cycle; ATR signaling; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; NIPBL role in DNA damage - Cornelia de Lange syndrome; DNA damage response" "19" "0" "0.971" "0.957" "1.027" "0.994" "1.006" "0.979" "0.930" "1.034" "0.996" "1279.7" "1242.2" "1224.2" "1314.8" "1272.5" "1287.8" "1252.4" "1190.0" "1322.9" "1274.7" "" "" "" "" "" "" "" "" "" "" "1027.9" "896.3" "972.5" "880.9" "880.1" "966.2" "876.9" "869.1" "1322.9" "1036.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262378899326464303" "False" "High" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "0.000" "False" "78.890" "51" "8" "16" "8" "216" "24.5" "5.34" "65.85" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "Unwinding of DNA" "" "1" "0" "0.998" "0.978" "1.004" "1.114" "1.023" "1.068" "1.100" "1.047" "1.068" "786.0" "784.2" "768.6" "788.8" "875.9" "804.3" "839.5" "864.5" "823.2" "839.7" "" "" "" "" "" "" "" "" "" "" "631.3" "565.9" "610.5" "528.5" "605.8" "603.5" "587.8" "631.3" "823.2" "682.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-191513720103364216" "False" "High" "IsMasterProtein" "Q8TAA3" "Proteasome subunit alpha-type 8 OS=Homo sapiens OX=9606 GN=PSMA8 PE=1 SV=3" "0.000" "False" "78.694" "55" "12" "16" "8" "256" "28.5" "8.98" "64.85" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "Pf00227, Pf10584" "143471" "ENSG00000154611" "PSMA8" "B0YJ75; hsa:143471; Q8IVP4; Q8TA98; Q8TAA2; Q8TAA3" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC)" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "54" "2" "0.991" "1.059" "1.080" "1.130" "1.093" "1.163" "1.054" "1.038" "1.081" "1145.4" "1135.2" "1212.9" "1237.1" "1293.9" "1251.6" "1332.7" "1207.5" "1188.7" "1238.5" "" "" "" "" "" "" "" "" "" "" "920.0" "819.1" "963.5" "828.8" "894.9" "939.0" "933.1" "881.9" "1188.7" "1007.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5808192534094495875" "False" "High" "IsMasterProtein" "Q9HC35" "Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3" "0.000" "False" "78.538" "17" "16" "19" "16" "981" "108.8" "6.40" "71.95" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "27436" "ENSG00000143924" "EML4" "A6H8Y6; A6P4T4; A6P4V4; B2RBK3; B2RTW7; B5MCW9; hsa:27436; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9HC35; Q9NV40" "EML4 and NUDC in mitotic spindle formation; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "Non-small cell lung cancer" "4" "0" "0.970" "0.985" "0.997" "1.003" "0.978" "0.956" "0.984" "1.022" "0.991" "2016.2" "1956.2" "1986.8" "2010.9" "2022.1" "1972.8" "1927.1" "1984.2" "2060.4" "1997.4" "" "" "" "" "" "" "" "" "" "" "1619.4" "1411.5" "1578.2" "1347.3" "1398.5" "1480.2" "1349.2" "1449.1" "2060.4" "1624.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112180940687261840" "False" "High" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "0.000" "False" "78.478" "44" "7" "34" "7" "160" "18.7" "4.54" "133.62" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Potential therapeutics for SARS; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Omega-6-fatty acids in senescence" "12" "0" "1.032" "1.049" "0.970" "0.953" "1.006" "0.972" "0.984" "0.957" "0.949" "3860.7" "3982.7" "4048.5" "3744.1" "3678.7" "3885.3" "3752.8" "3797.7" "3695.3" "3662.9" "" "" "" "" "" "" "" "" "" "" "3100.9" "2873.8" "3215.9" "2508.6" "2544.2" "2915.1" "2627.5" "2773.5" "3695.3" "2978.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678846149867540289" "False" "High" "IsMasterProtein" "Q9H4A4" "Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2" "0.000" "False" "78.345" "26" "15" "16" "15" "650" "72.5" "5.74" "59.85" "15" "protein metabolism" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01433, Pf09127, Pf17900" "6051" "ENSG00000176393" "RNPEP" "hsa:6051; Q9BVM9; Q9H1D4; Q9H4A4; Q9NPT7" "" "" "0" "0" "1.079" "0.956" "1.065" "1.076" "1.039" "1.074" "0.999" "1.025" "1.032" "1422.5" "1534.7" "1360.6" "1514.8" "1530.9" "1477.6" "1527.4" "1421.1" "1457.5" "1467.4" "" "" "" "" "" "" "" "" "" "" "1142.5" "1107.4" "1080.7" "1014.9" "1058.8" "1108.6" "1069.4" "1037.8" "1457.5" "1193.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4793391525152750587" "False" "High" "IsMasterProtein" "P61020" "Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1" "0.000" "False" "78.192" "48" "8" "15" "5" "215" "23.7" "8.13" "52.95" "8" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5869" "ENSG00000111540" "RAB5B" "A8K982; B4DKD7; hsa:5869; P35239; P35277; P61020; Q6PIK9; Q86TH0; Q8IXL2" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "9" "0" "1.067" "1.074" "1.023" "1.020" "1.024" "1.040" "1.054" "1.048" "1.030" "352.7" "376.2" "378.7" "360.6" "359.6" "361.2" "366.8" "371.7" "369.7" "363.3" "" "" "" "" "" "" "" "" "" "" "283.3" "271.5" "300.8" "241.6" "248.7" "271.0" "256.8" "271.5" "369.7" "295.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197939441703168183" "False" "High" "IsMasterProtein" "Cont_P12763" "Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2" "0.000" "True" "78.180" "34" "9" "19" "9" "359" "38.4" "5.50" "74.71" "9" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00031" "280988" "ENSBTAG00000000522" "AHSG" "A6QLF7; B0JYN6; bta:280988; P12763" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "4" "0" "1.257" "0.864" "1.330" "0.970" "1.138" "1.706" "1.039" "0.926" "1.110" "795.1" "999.2" "687.0" "1057.3" "771.1" "904.6" "1356.2" "826.3" "735.9" "882.8" "" "" "" "" "" "" "" "" "" "" "638.6" "721.0" "545.7" "708.4" "533.3" "678.7" "949.5" "603.5" "735.9" "717.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534228375388649933" "False" "High" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "0.000" "False" "78.125" "10" "18" "21" "18" "1817" "197.5" "6.40" "68.45" "18" "cell organization and biogenesis;protein metabolism;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110, Pf21240" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "1" "0" "1.048" "0.991" "1.037" "1.055" "1.089" "0.954" "1.087" "1.088" "1.040" "1480.3" "1551.6" "1467.6" "1534.7" "1561.4" "1611.3" "1412.8" "1609.7" "1610.6" "1540.1" "" "" "" "" "" "" "" "" "" "" "1189.0" "1119.6" "1165.8" "1028.3" "1079.8" "1209.0" "989.2" "1175.6" "1610.6" "1252.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6701833234650983688" "False" "High" "IsMasterProtein" "O43865" "S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2" "0.000" "False" "78.084" "27" "16" "29" "7" "530" "58.9" "6.89" "93.32" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00670, Pf05221" "10768" "ENSG00000168710" "AHCYL1" "B4E168; hsa:10768; O43865; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "12" "7" "0.983" "0.952" "0.986" "0.941" "1.004" "1.008" "0.982" "0.949" "0.970" "2398.3" "2356.8" "2282.7" "2364.3" "2256.9" "2408.2" "2417.1" "2354.4" "2276.6" "2325.7" "" "" "" "" "" "" "" "" "" "" "1926.3" "1700.6" "1813.2" "1584.1" "1560.9" "1806.8" "1692.4" "1719.4" "2276.6" "1891.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9009655612245832545" "False" "High" "IsMasterProtein" "Q9Y4G6" "Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4" "0.000" "False" "78.041" "6" "16" "23" "2" "2542" "271.4" "5.57" "80.79" "16" "cell adhesion;cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf09379, Pf16511, Pf21692" "83660" "ENSG00000171914" "TLN2" "A6NLB8; hsa:83660; Q9Y4G6" "" "Focal adhesion" "1" "0" "1.087" "0.794" "1.195" "1.336" "0.915" "1.042" "0.913" "1.072" "1.139" "35.2" "38.2" "27.9" "42.0" "47.0" "32.2" "36.6" "32.1" "37.7" "40.0" "" "" "" "" "" "" "" "" "" "" "28.2" "27.6" "22.2" "28.1" "32.5" "24.1" "25.6" "23.4" "37.7" "32.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021829867861972309" "False" "High" "IsMasterProtein" "Q14671" "Pumilio homolog 1 OS=Homo sapiens OX=9606 GN=PUM1 PE=1 SV=3" "0.000" "False" "77.995" "16" "16" "21" "13" "1186" "126.4" "6.84" "68.20" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "9698" "ENSG00000134644" "PUM1" "A8K6W4; B4DG92; D3DPN3; E9PCJ0; hsa:9698; Q14671; Q53HH5; Q5VXY7; Q9HAN1" "Golgi Associated Vesicle Biogenesis" "" "1" "2" "1.021" "1.007" "1.061" "1.019" "0.967" "1.009" "1.015" "0.968" "1.038" "2021.3" "2063.3" "2035.4" "2145.5" "2059.5" "1954.5" "2040.5" "2051.5" "1956.8" "2099.0" "" "" "" "" "" "" "" "" "" "" "1623.5" "1488.8" "1616.8" "1437.5" "1424.3" "1466.4" "1428.6" "1498.2" "1956.8" "1707.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "866424040394030727" "False" "High" "IsMasterProtein" "Q15052" "Rho guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=ARHGEF6 PE=1 SV=2" "0.000" "False" "77.955" "20" "15" "20" "13" "776" "87.4" "6.05" "72.85" "15" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16523, Pf16614, Pf16615" "9459" "ENSG00000129675" "ARHGEF6" "A6NMW9; A8K6S7; B1AL37; hsa:9459; Q15052; Q15396; Q5JQ66; Q7Z3W1; Q86XH0" "G alpha (12/13) signalling events; G beta:gamma signalling through CDC42; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle; NRAGE signals death through JNK; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Pancreatic adenocarcinoma pathway; Regulation of actin cytoskeleton" "9" "2" "1.033" "1.000" "1.057" "1.018" "1.020" "0.982" "1.088" "1.012" "1.071" "1479.3" "1528.7" "1479.3" "1563.0" "1506.1" "1508.6" "1452.8" "1610.1" "1497.2" "1584.3" "" "" "" "" "" "" "" "" "" "" "1188.2" "1103.1" "1175.1" "1047.2" "1041.6" "1131.9" "1017.2" "1175.8" "1497.2" "1288.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2595781739747339031" "False" "High" "IsMasterProtein" "Q14677" "Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1" "0.000" "False" "77.948" "22" "14" "20" "13" "625" "68.2" "6.42" "64.25" "14" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "9685" "ENSG00000113282" "CLINT1" "B7Z6F8; D3DQJ6; hsa:9685; Q14677; Q8NAF1; Q96E05" "Golgi Associated Vesicle Biogenesis" "" "1" "1" "0.969" "0.978" "1.001" "1.048" "1.026" "1.103" "1.048" "1.060" "1.054" "2003.7" "1940.8" "1958.9" "2005.5" "2099.5" "2054.9" "2209.6" "2099.1" "2124.4" "2111.7" "" "" "" "" "" "" "" "" "" "" "1609.3" "1400.4" "1556.0" "1343.7" "1452.0" "1541.7" "1547.0" "1533.0" "2124.4" "1717.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5272844491039920934" "False" "High" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "0.000" "False" "77.907" "46" "10" "26" "10" "255" "28.4" "8.62" "77.59" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "mRNA processing" "3" "0" "1.044" "1.041" "1.029" "1.119" "1.080" "1.050" "1.113" "1.004" "1.050" "2002.6" "2090.4" "2084.4" "2061.2" "2240.9" "2162.5" "2102.4" "2229.5" "2011.6" "2103.2" "" "" "" "" "" "" "" "" "" "" "1608.5" "1508.4" "1655.7" "1381.0" "1549.9" "1622.5" "1472.0" "1628.2" "2011.6" "1710.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4145241579063427930" "False" "High" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "0.000" "False" "77.853" "35" "11" "18" "10" "391" "45.1" "7.74" "61.76" "11" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "22" "1" "1.016" "1.081" "0.981" "0.939" "1.025" "0.946" "1.062" "0.981" "1.006" "1881.9" "1911.4" "2035.2" "1846.0" "1767.6" "1929.1" "1779.7" "1998.3" "1845.5" "1893.5" "" "" "" "" "" "" "" "" "" "" "1511.5" "1379.2" "1616.7" "1236.8" "1222.5" "1447.4" "1246.1" "1459.4" "1845.5" "1539.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9037349892504840241" "False" "High" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "0.000" "False" "77.813" "44" "12" "25" "12" "312" "35.1" "6.13" "85.41" "12" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "O00764; Q7Z2Y0; Q9BS02" "Neutrophil degranulation; Vitamin B6 activation to pyridoxal phosphate" "" "2" "0" "1.019" "1.010" "1.001" "0.941" "1.025" "0.956" "0.908" "0.989" "1.007" "1791.8" "1826.2" "1809.1" "1793.7" "1685.9" "1837.3" "1712.3" "1626.5" "1772.5" "1803.5" "" "" "" "" "" "" "" "" "" "" "1439.2" "1317.8" "1437.0" "1201.8" "1166.0" "1378.5" "1198.9" "1187.8" "1772.5" "1466.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8114162095880212588" "False" "High" "IsMasterProtein" "Q9H3S7" "Tyrosine-protein phosphatase non-receptor type 23 OS=Homo sapiens OX=9606 GN=PTPN23 PE=1 SV=1" "0.000" "False" "77.785" "10" "16" "20" "16" "1636" "178.9" "6.92" "64.97" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102, Pf03097, Pf13949" "25930" "ENSG00000076201" "PTPN23" "A8K0D7; hsa:25930; Q7KZF8; Q8N6Z5; Q9BSR5; Q9H3S7; Q9P257; Q9UG03; Q9UMZ4" "Interleukin-37 signaling" "" "1" "0" "1.017" "0.935" "0.963" "1.001" "0.917" "0.919" "0.936" "0.971" "1.003" "898.2" "913.9" "840.2" "865.1" "899.2" "823.5" "825.5" "840.4" "872.6" "900.9" "" "" "" "" "" "" "" "" "" "" "721.5" "659.4" "667.4" "579.6" "621.9" "617.9" "578.0" "613.8" "872.6" "732.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274876564336853802" "False" "High" "IsMasterProtein" "Q01804" "OTU domain-containing protein 4 OS=Homo sapiens OX=9606 GN=OTUD4 PE=1 SV=4" "0.000" "False" "77.701" "16" "15" "18" "15" "1114" "124.0" "6.71" "59.27" "15" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02338" "54726" "ENSG00000164164" "OTUD4" "B4DYS4; hsa:54726; Q01804; Q147U2; Q1ZYK1; Q6PG39; Q96MQ5; Q9NT94; Q9UPV6" "" "" "0" "0" "0.967" "0.948" "0.986" "0.978" "0.948" "0.957" "0.979" "1.007" "1.016" "768.0" "742.8" "728.1" "757.5" "751.4" "728.1" "735.0" "752.1" "773.6" "780.1" "" "" "" "" "" "" "" "" "" "" "616.9" "536.0" "578.3" "507.5" "519.7" "546.3" "514.6" "549.3" "773.6" "634.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5348588292702008792" "False" "High" "IsMasterProtein" "O94888" "UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2" "0.000" "False" "77.672" "32" "13" "21" "13" "489" "54.8" "5.16" "77.10" "13" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf13899, Pf14555" "26043" "ENSG00000163960" "UBXN7" "D3DXB3; hsa:26043; O94888; Q6ZP77; Q86X20; Q8N327" "Neddylation; KEAP1-NFE2L2 pathway" "3q29 copy number variation syndrome" "3" "0" "1.031" "0.985" "1.033" "1.008" "1.004" "1.002" "1.046" "1.007" "1.009" "1201.0" "1238.4" "1182.6" "1241.0" "1211.2" "1206.0" "1203.1" "1256.0" "1209.0" "1211.5" "" "" "" "" "" "" "" "" "" "" "964.6" "893.6" "939.4" "831.5" "837.7" "904.9" "842.3" "917.3" "1209.0" "985.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774466273942528480" "False" "High" "IsMasterProtein" "O43379" "WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4" "0.000" "False" "77.666" "12" "15" "16" "15" "1518" "165.8" "5.91" "58.34" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "" "Pf00400" "284403" "ENSG00000075702" "WDR62" "hsa:284403; O43379; Q63HP9; Q659D7; Q8NBF7; Q96AD9" "" "Primary ovarian insufficiency" "1" "0" "1.073" "0.986" "0.991" "1.042" "1.008" "0.985" "0.970" "0.970" "1.038" "870.1" "933.2" "858.0" "862.0" "906.6" "877.3" "857.1" "844.2" "844.1" "903.6" "" "" "" "" "" "" "" "" "" "" "698.9" "673.4" "681.6" "577.6" "627.0" "658.3" "600.1" "616.6" "844.1" "734.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5720484629679422275" "False" "High" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "0.000" "False" "77.583" "28" "12" "20" "12" "492" "57.2" "5.92" "73.03" "12" "" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "mRNA Splicing - Major Pathway" "" "1" "0" "0.984" "0.980" "1.023" "1.078" "0.999" "1.089" "1.089" "1.048" "1.040" "2807.7" "2763.6" "2752.8" "2871.9" "3027.6" "2805.1" "3058.3" "3057.5" "2941.3" "2920.0" "" "" "" "" "" "" "" "" "" "" "2255.1" "1994.1" "2186.6" "1924.1" "2093.9" "2104.6" "2141.3" "2232.9" "2941.3" "2374.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2473277628257978921" "False" "High" "IsMasterProtein" "Q5SRE5" "Nucleoporin NUP188 OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1" "0.000" "False" "77.564" "12" "19" "20" "19" "1749" "195.9" "6.73" "66.81" "19" "transport" "cytosol;nucleus" "other molecular function" "Pf10487, Pf21093, Pf21094" "23511" "ENSG00000095319" "NUP188" "hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1" "Vpr-mediated nuclear import of PICs; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "1.021" "0.966" "1.001" "1.044" "1.023" "0.968" "1.097" "1.061" "1.038" "1227.0" "1253.0" "1184.9" "1228.6" "1281.2" "1255.7" "1187.6" "1345.4" "1301.5" "1273.5" "" "" "" "" "" "" "" "" "" "" "985.5" "904.2" "941.2" "823.2" "886.1" "942.2" "831.5" "982.6" "1301.5" "1035.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4399142244827454415" "False" "High" "IsMasterProtein" "Q8NFD5" "AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3" "0.000" "False" "77.537" "8" "16" "19" "14" "2319" "243.8" "6.90" "68.85" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "57492" "ENSG00000049618" "ARID1B" "hsa:57492; Q5JRD1; Q5VYC4; Q8IZY8; Q8NFD5; Q8TEV0; Q8TF02; Q99491; Q9ULI5" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "1.031" "0.977" "1.035" "0.968" "1.019" "0.960" "1.016" "1.004" "0.987" "1581.3" "1630.9" "1544.4" "1636.8" "1530.6" "1611.1" "1518.6" "1606.5" "1587.5" "1561.1" "" "" "" "" "" "" "" "" "" "" "1270.1" "1176.8" "1226.8" "1096.7" "1058.6" "1208.8" "1063.2" "1173.2" "1587.5" "1269.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5376062369618088086" "False" "High" "IsMasterProtein" "P01834" "Immunoglobulin kappa constant OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=2" "0.000" "False" "77.529" "79" "5" "25" "5" "107" "11.8" "6.52" "96.43" "5" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07654" "" "" "IGKC" "A0A075B6H6; A0A087X130; P01834" "Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "" "19" "0" "1.014" "1.020" "0.946" "1.022" "1.032" "0.934" "1.029" "0.888" "0.977" "2092.2" "2122.2" "2133.1" "1979.5" "2137.5" "2159.1" "1953.4" "2152.7" "1858.1" "2043.3" "" "" "" "" "" "" "" "" "" "" "1680.4" "1531.3" "1694.4" "1326.3" "1478.3" "1619.9" "1367.7" "1572.1" "1858.1" "1661.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1645614495321622240" "False" "High" "IsMasterProtein" "P57678" "Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2" "0.000" "False" "77.484" "15" "16" "22" "16" "1058" "120.0" "6.04" "77.29" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "50628" "ENSG00000179409" "GEMIN4" "hsa:50628; P57678; Q9NZS7; Q9UG32; Q9Y4Q2" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "1.040" "0.987" "1.032" "0.981" "0.971" "0.934" "1.016" "0.955" "0.961" "1938.5" "2015.3" "1913.8" "2000.4" "1901.2" "1882.1" "1811.0" "1968.6" "1851.3" "1862.4" "" "" "" "" "" "" "" "" "" "" "1557.0" "1454.2" "1520.2" "1340.2" "1314.9" "1412.1" "1268.0" "1437.6" "1851.3" "1514.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6052535811300559173" "False" "High" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "0.000" "False" "77.399" "21" "13" "23" "13" "804" "91.8" "7.42" "79.73" "13" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.990" "0.968" "1.107" "1.113" "1.025" "1.118" "1.096" "1.067" "1.071" "1348.4" "1335.2" "1305.8" "1493.1" "1500.5" "1382.5" "1507.4" "1478.1" "1438.7" "1444.1" "" "" "" "" "" "" "" "" "" "" "1083.0" "963.5" "1037.2" "1000.4" "1037.8" "1037.2" "1055.4" "1079.5" "1438.7" "1174.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4929708673540461466" "False" "High" "IsMasterProtein" "Q9UHP3" "Ubiquitin carboxyl-terminal hydrolase 25 OS=Homo sapiens OX=9606 GN=USP25 PE=1 SV=4" "0.000" "False" "77.390" "17" "15" "18" "15" "1055" "122.1" "5.34" "60.36" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00443, Pf02809" "29761" "ENSG00000155313" "USP25" "C0LSZ0; hsa:29761; Q6DHZ9; Q9H9W1; Q9UHP3" "Ub-specific processing proteases" "" "1" "0" "1.034" "1.030" "1.107" "1.106" "1.078" "1.023" "1.012" "1.059" "1.060" "1506.2" "1556.8" "1551.7" "1666.8" "1665.6" "1623.6" "1540.3" "1524.3" "1594.8" "1597.1" "" "" "" "" "" "" "" "" "" "" "1209.8" "1123.3" "1232.6" "1116.8" "1151.9" "1218.2" "1078.5" "1113.2" "1594.8" "1298.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585168671336988915" "False" "High" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=3" "0.000" "False" "77.365" "26" "22" "29" "21" "825" "94.8" "6.55" "94.04" "22" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "A0A5F9UK94; B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "Purine salvage" "" "1" "1" "1.024" "0.995" "1.046" "1.066" "1.009" "1.021" "1.006" "1.002" "1.039" "2204.7" "2258.4" "2194.3" "2305.1" "2349.9" "2223.8" "2250.0" "2218.2" "2209.0" "2290.1" "" "" "" "" "" "" "" "" "" "" "1770.8" "1629.6" "1743.0" "1544.4" "1625.2" "1668.4" "1575.3" "1619.9" "2209.0" "1862.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2160621710341352314" "False" "High" "IsMasterProtein" "O14964" "Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1" "0.000" "False" "77.323" "15" "12" "22" "12" "777" "86.1" "6.16" "78.07" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf01363, Pf12210" "9146" "ENSG00000185359" "HGS" "hsa:9146; O14964; Q9NR36" "Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway" "16" "0" "1.024" "1.028" "1.034" "1.023" "1.019" "0.957" "0.997" "1.075" "1.035" "1601.1" "1640.2" "1646.3" "1655.8" "1638.4" "1632.1" "1531.8" "1595.6" "1721.1" "1657.6" "" "" "" "" "" "" "" "" "" "" "1286.0" "1183.5" "1307.7" "1109.4" "1133.1" "1224.6" "1072.5" "1165.3" "1721.1" "1348.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088025864314276117" "False" "High" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "0.000" "False" "77.308" "20" "10" "18" "9" "577" "63.1" "9.44" "67.89" "10" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "0" "1.001" "0.975" "1.016" "1.022" "1.054" "1.023" "1.046" "1.059" "1.003" "1572.1" "1574.4" "1533.1" "1597.1" "1607.4" "1657.1" "1607.8" "1644.6" "1664.7" "1576.3" "" "" "" "" "" "" "" "" "" "" "1262.7" "1136.0" "1217.8" "1070.1" "1111.7" "1243.3" "1125.7" "1201.1" "1664.7" "1281.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8046944082778510554" "False" "High" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "0.000" "False" "77.189" "33" "9" "35" "8" "198" "21.9" "5.97" "123.01" "9" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Selenium micronutrient network; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "6" "0" "0.950" "0.993" "0.868" "0.952" "0.949" "0.832" "0.853" "1.015" "0.931" "2746.3" "2609.0" "2725.9" "2382.8" "2613.3" "2605.6" "2285.0" "2342.6" "2787.5" "2556.9" "" "" "" "" "" "" "" "" "" "" "2205.8" "1882.6" "2165.3" "1596.5" "1807.4" "1955.0" "1599.8" "1710.8" "2787.5" "2079.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4941414792679987409" "False" "High" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "0.000" "False" "77.130" "50" "12" "20" "12" "316" "34.8" "8.35" "64.96" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "1.013" "0.985" "0.998" "1.005" "0.933" "0.998" "1.042" "1.027" "1.003" "1624.5" "1646.1" "1599.6" "1621.8" "1633.3" "1516.3" "1620.5" "1692.4" "1669.1" "1629.0" "" "" "" "" "" "" "" "" "" "" "1304.8" "1187.8" "1270.6" "1086.6" "1129.6" "1137.6" "1134.6" "1236.0" "1669.1" "1324.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-508494988063673287" "False" "High" "IsMasterProtein" "Q9NXG2" "THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2" "0.000" "False" "77.096" "41" "12" "18" "12" "353" "39.3" "7.88" "60.98" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02926" "55623" "ENSG00000066654" "THUMPD1" "hsa:55623; Q9BWC3; Q9NXG2" "rRNA modification in the nucleus and cytosol" "" "1" "0" "1.003" "1.005" "0.883" "0.906" "0.956" "0.899" "0.878" "0.875" "0.929" "1576.2" "1580.9" "1583.3" "1392.1" "1428.7" "1507.1" "1416.5" "1383.7" "1379.8" "1465.0" "" "" "" "" "" "" "" "" "" "" "1266.0" "1140.7" "1257.7" "932.7" "988.1" "1130.8" "991.8" "1010.5" "1379.8" "1191.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5172052490398288729" "False" "High" "IsMasterProtein" "Q9H9S4" "Calcium-binding protein 39-like OS=Homo sapiens OX=9606 GN=CAB39L PE=1 SV=3" "0.000" "False" "77.055" "36" "13" "35" "11" "337" "39.1" "8.40" "112.66" "13" "signal transduction" "cytosol;other cell component" "enzyme regulator activity" "Pf08569" "81617" "ENSG00000102547" "CAB39L" "hsa:81617; Q5TAW6; Q6WG71; Q96FG1; Q9BZ33; Q9H9S4" "Energy dependent regulation of mTOR by LKB1-AMPK" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "2" "0" "0.934" "0.977" "0.895" "0.938" "0.952" "0.997" "0.921" "0.939" "0.943" "2061.9" "1925.8" "2013.7" "1844.5" "1933.9" "1962.0" "2056.0" "1898.1" "1936.7" "1945.2" "" "" "" "" "" "" "" "" "" "" "1656.1" "1389.6" "1599.5" "1235.8" "1337.5" "1472.0" "1439.5" "1386.2" "1936.7" "1581.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413684009215812555" "False" "High" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "0.000" "False" "77.045" "34" "11" "20" "11" "372" "40.9" "8.35" "78.73" "11" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "6" "0" "0.983" "0.992" "0.990" "1.014" "1.007" "1.025" "0.973" "0.964" "1.004" "2288.2" "2248.5" "2270.4" "2266.4" "2320.4" "2303.9" "2345.9" "2225.8" "2205.6" "2298.1" "" "" "" "" "" "" "" "" "" "" "1837.8" "1622.4" "1803.4" "1518.5" "1604.8" "1728.6" "1642.5" "1625.5" "2205.6" "1868.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9189590484777075943" "False" "High" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "0.000" "False" "76.971" "45" "8" "27" "6" "183" "20.8" "5.33" "98.36" "8" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "RNA Polymerase I Promoter Escape; Transcriptional Regulation by E2F6; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Exercise-induced circadian regulation; Effect of progerin on genes involved in progeria; NIPBL role in DNA damage - Cornelia de Lange syndrome" "6" "1" "1.018" "1.115" "1.084" "1.019" "1.058" "1.055" "0.967" "0.936" "0.972" "2419.8" "2462.8" "2697.7" "2623.4" "2466.4" "2559.8" "2553.1" "2339.1" "2264.8" "2351.2" "" "" "" "" "" "" "" "" "" "" "1943.6" "1777.1" "2142.9" "1757.7" "1705.8" "1920.6" "1787.5" "1708.3" "2264.8" "1912.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669002677123591675" "False" "High" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "0.000" "False" "76.669" "52" "13" "30" "10" "297" "34.1" "8.40" "94.33" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "Golgi Cisternae Pericentriolar Stack Reorganization; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "50" "2" "0.973" "1.032" "0.919" "0.884" "0.930" "0.745" "0.779" "0.826" "0.890" "3272.0" "3182.6" "3375.7" "3007.5" "2892.8" "3042.3" "2438.8" "2548.6" "2704.2" "2911.7" "" "" "" "" "" "" "" "" "" "" "2628.0" "2296.5" "2681.5" "2015.1" "2000.7" "2282.6" "1707.5" "1861.3" "2704.2" "2367.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513185524036398277" "False" "High" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "0.000" "False" "76.666" "37" "17" "30" "17" "528" "60.5" "7.52" "95.21" "17" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "0" "1.084" "1.055" "1.080" "1.025" "1.053" "1.034" "0.994" "1.005" "1.047" "3484.0" "3777.8" "3674.0" "3762.1" "3569.6" "3669.5" "3601.3" "3461.7" "3503.1" "3646.6" "" "" "" "" "" "" "" "" "" "" "2798.3" "2726.0" "2918.4" "2520.6" "2468.8" "2753.2" "2521.4" "2528.1" "3503.1" "2965.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7223228418441482962" "False" "High" "IsMasterProtein" "Q15648" "Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4" "0.000" "False" "76.528" "11" "14" "16" "14" "1581" "168.4" "8.73" "52.99" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10744" "5469" "ENSG00000125686" "MED1" "A2RRQ6; hsa:5469; O43810; O75447; Q15648; Q6P9H7; Q6PK58; Q9HD39" "Estrogen-dependent gene expression; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "Energy metabolism; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Non-genomic actions of 1,25 dihydroxyvitamin D3; 17q12 copy number variation syndrome" "18" "0" "0.971" "0.970" "0.996" "0.962" "0.964" "0.914" "0.950" "0.968" "0.901" "1040.2" "1010.2" "1009.2" "1036.4" "1000.5" "1002.9" "950.9" "988.1" "1006.7" "937.2" "" "" "" "" "" "" "" "" "" "" "835.5" "728.9" "801.6" "694.4" "691.9" "752.4" "665.8" "721.6" "1006.7" "762.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-938207872866175487" "False" "High" "IsMasterProtein" "Q00534" "Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1" "0.000" "False" "76.490" "38" "11" "24" "10" "326" "36.9" "6.46" "81.65" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1021" "ENSG00000105810" "CDK6" "A4D1G0; hsa:1021; Q00534" "Cyclin D associated events in G1; Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "30" "0" "0.985" "1.019" "0.992" "0.967" "0.969" "0.971" "0.983" "0.977" "0.954" "2500.9" "2464.3" "2547.8" "2481.6" "2417.4" "2423.2" "2427.4" "2457.8" "2442.6" "2385.9" "" "" "" "" "" "" "" "" "" "" "2008.7" "1778.1" "2023.8" "1662.7" "1671.9" "1818.1" "1699.5" "1795.0" "2442.6" "1940.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965270540937199853" "False" "High" "IsMasterProtein" "Q14151" "Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1" "0.000" "False" "76.443" "12" "10" "23" "5" "953" "107.4" "6.16" "80.88" "10" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "9667" "ENSG00000130254" "SAFB2" "B4DKG3; hsa:9667; Q14151; Q8TB13" "" "" "0" "0" "0.919" "0.961" "0.981" "1.044" "1.058" "1.103" "0.981" "1.036" "1.066" "691.9" "635.7" "664.9" "679.1" "722.1" "732.0" "763.1" "678.8" "716.9" "737.8" "" "" "" "" "" "" "" "" "" "" "555.7" "458.7" "528.2" "455.0" "499.4" "549.2" "534.3" "495.7" "716.9" "600.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2588985702309620212" "False" "High" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "0.000" "False" "76.412" "39" "10" "14" "10" "299" "33.4" "5.25" "58.12" "10" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "1.004" "0.983" "0.960" "0.929" "0.947" "0.975" "0.994" "0.947" "0.977" "1332.0" "1337.3" "1309.0" "1278.0" "1238.0" "1260.8" "1298.4" "1324.6" "1261.2" "1301.3" "" "" "" "" "" "" "" "" "" "" "1069.8" "965.0" "1039.8" "856.3" "856.2" "946.0" "909.1" "967.3" "1261.2" "1058.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5925761923209875400" "False" "High" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "0.000" "False" "76.356" "32" "9" "18" "9" "385" "44.1" "6.23" "73.00" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855, Pf21459" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "8" "0" "0.987" "1.007" "1.028" "0.983" "0.937" "0.988" "1.038" "0.989" "1.019" "1262.8" "1247.0" "1272.1" "1298.6" "1241.5" "1183.2" "1247.6" "1310.4" "1249.1" "1287.2" "" "" "" "" "" "" "" "" "" "" "1014.3" "899.8" "1010.5" "870.0" "858.6" "887.7" "873.5" "957.0" "1249.1" "1046.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2297110738803864325" "False" "High" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "0.000" "False" "76.314" "48" "7" "24" "7" "214" "22.1" "8.70" "81.38" "7" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "" "Selenium micronutrient network" "1" "0" "0.937" "1.010" "0.941" "0.952" "0.941" "0.952" "0.992" "0.918" "0.964" "2785.2" "2610.8" "2814.1" "2621.7" "2651.8" "2619.9" "2651.5" "2763.4" "2556.6" "2684.7" "" "" "" "" "" "" "" "" "" "" "2237.0" "1883.9" "2235.3" "1756.5" "1834.0" "1965.7" "1856.4" "2018.1" "2556.6" "2183.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3054856418516569750" "False" "High" "IsMasterProtein" "Q8IZ07" "Ankyrin repeat domain-containing protein 13A OS=Homo sapiens OX=9606 GN=ANKRD13A PE=1 SV=3" "0.000" "False" "76.266" "23" "10" "17" "10" "590" "67.6" "5.02" "71.63" "10" "other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11904, Pf12796" "88455" "ENSG00000076513" "ANKRD13A" "hsa:88455; O60736; Q8IZ07" "" "" "0" "0" "0.994" "0.892" "0.987" "0.946" "0.934" "0.911" "0.984" "0.919" "0.977" "1159.4" "1152.0" "1033.8" "1144.0" "1096.9" "1083.4" "1056.6" "1141.1" "1065.2" "1132.9" "" "" "" "" "" "" "" "" "" "" "931.2" "831.3" "821.2" "766.4" "758.6" "812.8" "739.8" "833.3" "1065.2" "921.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602347345364685954" "False" "High" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "0.000" "False" "76.147" "33" "10" "60" "6" "215" "24.9" "5.74" "186.92" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "ER-Phagosome pathway; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Suppression of HMGB1-mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "20" "0" "1.096" "1.114" "1.111" "1.212" "1.206" "1.197" "1.245" "1.244" "1.167" "3924.7" "4301.2" "4370.3" "4362.0" "4758.4" "4734.8" "4696.2" "4887.5" "4883.4" "4579.6" "" "" "" "" "" "" "" "" "" "" "3152.2" "3103.6" "3471.5" "2922.6" "3291.0" "3552.4" "3288.0" "3569.3" "4883.4" "3724.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-684970281821863116" "False" "High" "IsMasterProtein" "Q9BXW9" "Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2" "0.000" "False" "76.009" "13" "15" "19" "15" "1451" "164.0" "5.88" "63.89" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf14631" "2177" "ENSG00000144554" "FANCD2" "hsa:2177; Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9BXW9; Q9H9T9" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "miRNA regulation of DNA damage response; 15q13.3 copy number variation syndrome; DNA repair pathways, full network; 15q11q13 copy number variation; DNA damage response" "7" "0" "1.037" "0.981" "1.025" "1.021" "0.994" "0.916" "0.981" "1.027" "0.978" "1360.5" "1410.3" "1335.1" "1394.2" "1389.7" "1352.1" "1246.8" "1335.2" "1397.6" "1331.0" "" "" "" "" "" "" "" "" "" "" "1092.7" "1017.6" "1060.5" "934.1" "961.1" "1014.5" "873.0" "975.1" "1397.6" "1082.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491360545906137157" "False" "High" "IsMasterProtein" "P54920" "Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3" "0.000" "False" "75.951" "49" "11" "17" "11" "295" "33.2" "5.36" "57.24" "11" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf14938" "8775" "ENSG00000105402" "NAPA" "A8K879; hsa:8775; P54920; Q96IK3; Q9BVJ3" "Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling" "8" "0" "1.015" "0.956" "1.076" "1.066" "1.118" "1.155" "1.058" "1.120" "1.065" "973.1" "987.4" "930.1" "1047.0" "1036.9" "1087.7" "1123.9" "1029.7" "1089.6" "1036.8" "" "" "" "" "" "" "" "" "" "" "781.6" "712.5" "738.8" "701.5" "717.1" "816.0" "786.9" "752.0" "1089.6" "843.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-566189082840404496" "False" "High" "IsMasterProtein" "Q8WVM7" "Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3" "0.000" "False" "75.938" "16" "19" "28" "15" "1258" "144.3" "5.59" "90.43" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10274" "ENSG00000118007" "STAG1" "hsa:10274; O00539; Q6P275; Q8WVM7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "10" "0" "1.035" "0.984" "1.002" "0.934" "0.954" "0.988" "0.980" "0.931" "0.989" "1549.4" "1604.3" "1524.0" "1552.3" "1447.3" "1478.7" "1530.5" "1518.8" "1443.2" "1532.9" "" "" "" "" "" "" "" "" "" "" "1244.5" "1157.6" "1210.6" "1040.1" "1000.9" "1109.4" "1071.6" "1109.2" "1443.2" "1246.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895528791649615838" "False" "High" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "0.000" "False" "75.842" "26" "11" "16" "11" "582" "63.8" "9.32" "63.10" "11" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "3" "0" "1.065" "0.980" "1.067" "1.063" "1.021" "1.112" "1.145" "1.103" "1.064" "978.8" "1042.8" "959.4" "1044.9" "1040.7" "999.1" "1088.1" "1120.5" "1079.4" "1041.2" "" "" "" "" "" "" "" "" "" "" "786.2" "752.5" "762.1" "700.1" "719.8" "749.6" "761.9" "818.3" "1079.4" "846.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490413544944086937" "False" "High" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "0.000" "False" "75.815" "45" "5" "17" "5" "153" "16.9" "6.60" "77.78" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "2" "0" "1.033" "0.989" "1.086" "1.010" "0.982" "1.050" "0.993" "0.922" "0.985" "1368.2" "1413.0" "1352.8" "1486.4" "1381.8" "1344.0" "1437.1" "1359.3" "1262.0" "1347.7" "" "" "" "" "" "" "" "" "" "" "1098.9" "1019.6" "1074.6" "995.9" "955.7" "1008.4" "1006.2" "992.7" "1262.0" "1096.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636367879172640363" "False" "High" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "0.000" "False" "75.746" "65" "7" "22" "7" "158" "18.0" "6.74" "77.72" "7" "" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.015" "1.025" "1.005" "0.953" "1.002" "0.991" "1.000" "1.012" "0.959" "1234.5" "1252.6" "1264.9" "1240.4" "1176.2" "1237.0" "1224.0" "1234.5" "1248.7" "1184.2" "" "" "" "" "" "" "" "" "" "" "991.5" "903.8" "1004.8" "831.1" "813.5" "928.1" "857.0" "901.6" "1248.7" "963.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2097918301010195378" "False" "High" "IsMasterProtein" "P28715" "DNA excision repair protein ERCC-5 OS=Homo sapiens OX=9606 GN=ERCC5 PE=1 SV=3" "0.000" "False" "75.663" "13" "12" "14" "12" "1186" "133.0" "5.22" "51.87" "12" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2073" "ENSG00000134899" "ERCC5" "A6NGT4; hsa:2073; P28715; Q5JUS4; Q5JUS5; Q7Z2V3; Q8IZL6; Q8N1B7; Q9HD59; Q9HD60" "Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; 10q11.21q11.23 copy number variation syndrome" "7" "0" "1.047" "1.066" "1.081" "1.037" "1.014" "0.932" "1.013" "0.999" "1.032" "768.9" "805.2" "820.0" "831.5" "797.6" "779.2" "716.3" "778.9" "768.1" "793.8" "" "" "" "" "" "" "" "" "" "" "617.5" "581.0" "651.3" "557.1" "551.6" "584.7" "501.5" "568.9" "768.1" "645.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429984818239481220" "False" "High" "IsMasterProtein" "O60488" "Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2" "0.000" "False" "75.627" "24" "15" "19" "15" "711" "79.1" "8.38" "62.80" "15" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00501" "2182" "ENSG00000068366" "ACSL4" "D3DUY2; hsa:2182; O60488; O60848; O60849; Q5JWV8" "Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders" "13" "0" "0.981" "0.974" "0.979" "0.946" "0.978" "0.985" "0.986" "0.998" "0.997" "1922.6" "1885.2" "1872.5" "1882.6" "1818.5" "1881.0" "1892.9" "1895.6" "1918.6" "1917.0" "" "" "" "" "" "" "" "" "" "" "1544.2" "1360.3" "1487.4" "1261.3" "1257.7" "1411.3" "1325.3" "1384.4" "1918.6" "1559.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8360736340109521171" "False" "High" "IsMasterProtein" "P57737" "Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7 PE=1 SV=2" "0.000" "False" "75.549" "19" "16" "20" "16" "925" "100.5" "5.80" "66.18" "16" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity" "Pf00400, Pf08953, Pf16300" "79585" "ENSG00000262246; ENSG00000282725" "CORO7" "B4DFD6; B4DL18; hsa:79585; I3L416; P57737; Q17RK4" "" "" "0" "0" "0.979" "1.023" "1.068" "1.022" "0.953" "0.990" "0.993" "1.004" "1.016" "1680.5" "1645.2" "1719.1" "1795.4" "1718.0" "1601.3" "1663.1" "1669.0" "1687.0" "1707.5" "" "" "" "" "" "" "" "" "" "" "1349.7" "1187.2" "1365.5" "1202.9" "1188.2" "1201.4" "1164.4" "1218.9" "1687.0" "1388.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4234558439794556747" "False" "High" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "0.000" "False" "75.472" "32" "14" "21" "14" "521" "56.7" "7.99" "66.64" "14" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; CDC42 GTPase cycle" "IL-18 signaling pathway; 5q35 copy number variation" "5" "0" "1.028" "0.998" "1.024" "1.048" "0.993" "1.009" "1.026" "0.989" "1.016" "1939.8" "1995.0" "1936.5" "1986.9" "2032.1" "1926.1" "1956.4" "1989.8" "1918.0" "1970.4" "" "" "" "" "" "" "" "" "" "" "1558.0" "1439.5" "1538.2" "1331.2" "1405.4" "1445.1" "1369.8" "1453.1" "1918.0" "1602.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002757993896463050" "False" "High" "IsMasterProtein" "Q9NQW6" "Anillin OS=Homo sapiens OX=9606 GN=ANLN PE=1 SV=2" "0.000" "False" "75.399" "13" "15" "18" "15" "1124" "124.1" "8.07" "65.74" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00169, Pf08174, Pf16018" "54443" "ENSG00000011426" "ANLN" "hsa:54443; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NQW6; Q9NVN9; Q9NVP0" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "Retinoblastoma gene in cancer; Nephrotic syndrome" "5" "0" "0.980" "0.993" "0.995" "0.964" "0.948" "1.110" "1.161" "1.175" "1.037" "1332.5" "1306.5" "1322.7" "1325.7" "1284.3" "1263.6" "1479.1" "1546.7" "1565.6" "1382.0" "" "" "" "" "" "" "" "" "" "" "1070.3" "942.8" "1050.6" "888.2" "888.2" "948.1" "1035.6" "1129.5" "1565.6" "1123.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5564362200897381814" "False" "High" "IsMasterProtein" "Q9P2N5" "RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2" "0.000" "False" "75.368" "16" "15" "19" "14" "1060" "118.6" "9.19" "64.13" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00076, Pf00642, Pf01480" "54439" "ENSG00000091009" "RBM27" "hsa:54439; Q8IYW9; Q9P2N5" "" "" "0" "0" "0.995" "1.100" "1.121" "1.109" "1.116" "1.113" "1.122" "1.119" "1.106" "1311.0" "1304.1" "1442.3" "1469.2" "1453.3" "1463.5" "1458.8" "1470.3" "1466.5" "1450.4" "" "" "" "" "" "" "" "" "" "" "1053.0" "941.0" "1145.6" "984.4" "1005.1" "1098.1" "1021.4" "1073.8" "1466.5" "1179.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815145421053809259" "False" "High" "IsMasterProtein" "Q16543" "Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1" "0.000" "False" "75.336" "26" "10" "44" "10" "378" "44.4" "5.25" "126.10" "10" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf03234, Pf08564, Pf08565" "11140" "ENSG00000105401" "CDC37" "hsa:11140; Q16543; Q53YA2" "Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RHOBTB2 GTPase cycle; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "27" "0" "1.028" "1.071" "1.009" "0.979" "1.016" "1.000" "1.012" "1.040" "0.998" "3400.5" "3496.5" "3640.6" "3431.2" "3329.8" "3456.1" "3399.7" "3442.6" "3535.9" "3392.1" "" "" "" "" "" "" "" "" "" "" "2731.3" "2523.0" "2891.8" "2298.9" "2302.9" "2593.0" "2380.3" "2514.2" "3535.9" "2758.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120785921578449656" "False" "High" "IsMasterProtein" "A0A0B4J2D5" "Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=5 SV=1" "0.000" "False" "75.307" "50" "9" "21" "9" "268" "28.1" "8.27" "78.20" "9" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "" "Gastric cancer network 1" "1" "0" "0.981" "0.991" "0.998" "0.986" "0.986" "0.966" "0.953" "0.918" "1.011" "1644.4" "1613.0" "1629.4" "1641.5" "1621.4" "1620.6" "1587.7" "1566.8" "1508.7" "1662.3" "" "" "" "" "" "" "" "" "" "" "1320.8" "1163.9" "1294.3" "1099.8" "1121.4" "1215.9" "1111.6" "1144.3" "1508.7" "1351.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644721245290312006" "False" "High" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "0.000" "False" "75.209" "35" "11" "20" "11" "423" "47.8" "6.65" "64.20" "11" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf21215" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Formation of TC-NER Pre-Incision Complex; Neddylation; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "6" "0" "1.003" "1.030" "1.030" "1.076" "1.058" "1.048" "1.064" "1.129" "1.049" "1843.9" "1849.8" "1899.9" "1898.9" "1983.9" "1950.6" "1932.8" "1962.1" "2081.9" "1934.8" "" "" "" "" "" "" "" "" "" "" "1481.0" "1334.8" "1509.1" "1272.3" "1372.1" "1463.5" "1353.3" "1432.9" "2081.9" "1573.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5859818642723021868" "False" "High" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "0.000" "False" "75.113" "27" "15" "20" "15" "583" "66.7" "5.11" "71.41" "15" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "0.961" "0.995" "1.137" "0.994" "0.957" "0.944" "0.936" "0.879" "0.972" "1911.2" "1836.4" "1902.6" "2172.7" "1899.5" "1828.7" "1803.4" "1789.5" "1679.9" "1857.4" "" "" "" "" "" "" "" "" "" "" "1535.1" "1325.1" "1511.3" "1455.7" "1313.7" "1372.0" "1262.7" "1306.9" "1679.9" "1510.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4208729749156870383" "False" "High" "IsMasterProtein" "O60678" "Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4" "0.000" "False" "75.100" "28" "12" "20" "12" "531" "59.9" "5.35" "75.72" "12" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf06325, Pf21137, Pf21336" "10196" "ENSG00000185238" "PRMT3" "A0A0A0MSN7; B4DUC7; hsa:10196; O60678" "RMTs methylate histone arginines; Protein methylation" "Nitric oxide metabolism in cystic fibrosis" "3" "0" "0.977" "0.970" "1.015" "0.989" "0.941" "0.941" "0.962" "0.931" "0.959" "1568.8" "1532.7" "1521.1" "1592.5" "1551.5" "1477.0" "1476.8" "1509.1" "1460.9" "1505.0" "" "" "" "" "" "" "" "" "" "" "1260.0" "1106.0" "1208.3" "1067.0" "1073.1" "1108.2" "1034.0" "1102.1" "1460.9" "1223.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5921429182500705176" "False" "High" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "0.000" "False" "75.072" "35" "10" "28" "10" "313" "34.0" "4.87" "94.26" "10" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "1.032" "1.063" "1.006" "0.966" "1.012" "1.006" "1.031" "1.016" "1.007" "2228.5" "2300.0" "2369.6" "2241.4" "2152.6" "2255.6" "2241.2" "2296.8" "2263.3" "2243.7" "" "" "" "" "" "" "" "" "" "" "1789.9" "1659.6" "1882.2" "1501.7" "1488.8" "1692.3" "1569.2" "1677.4" "2263.3" "1824.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5667017434232915728" "False" "High" "IsMasterProtein" "Q9Y618" "Nuclear receptor corepressor 2 OS=Homo sapiens OX=9606 GN=NCOR2 PE=1 SV=3" "0.000" "False" "75.065" "7" "14" "15" "13" "2514" "273.5" "7.59" "55.12" "14" "transport;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9612" "ENSG00000196498" "NCOR2" "hsa:9612; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; Q9Y618" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of transcription cofactors; HDACs deacetylate histones; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "Androgen receptor signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Notch signaling; Rett syndrome; Notch signaling pathway" "23" "0" "1.035" "0.996" "1.045" "1.003" "0.994" "0.993" "1.038" "1.039" "0.993" "1165.7" "1206.2" "1161.2" "1218.6" "1169.0" "1159.0" "1158.0" "1209.5" "1211.6" "1157.8" "" "" "" "" "" "" "" "" "" "" "936.3" "870.4" "922.4" "816.5" "808.5" "869.5" "810.7" "883.3" "1211.6" "941.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105590479105363220" "False" "High" "IsMasterProtein" "O60870" "DNA/RNA-binding protein KIN17 OS=Homo sapiens OX=9606 GN=KIN PE=1 SV=2" "0.000" "False" "75.041" "39" "13" "17" "13" "393" "45.3" "8.95" "61.09" "13" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10357, Pf18131" "22944" "ENSG00000151657" "KIN" "B4DX32; hsa:22944; O60870" "Protein methylation" "" "1" "0" "0.999" "1.017" "1.001" "1.018" "1.015" "0.959" "0.971" "1.028" "1.019" "1483.0" "1481.5" "1508.1" "1484.1" "1509.7" "1504.9" "1422.4" "1440.6" "1524.1" "1511.8" "" "" "" "" "" "" "" "" "" "" "1191.2" "1069.0" "1197.9" "994.4" "1044.1" "1129.1" "995.9" "1052.1" "1524.1" "1229.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1738440604026587204" "False" "High" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "0.000" "False" "75.015" "41" "8" "18" "7" "307" "35.1" "5.06" "67.93" "8" "DNA metabolism;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "Processing of DNA double-strand break ends" "16p11.2 proximal deletion syndrome" "2" "0" "1.035" "1.036" "1.062" "1.077" "1.124" "1.003" "1.026" "1.044" "1.085" "637.3" "659.5" "660.4" "677.0" "686.1" "716.1" "639.3" "653.8" "665.0" "691.4" "" "" "" "" "" "" "" "" "" "" "511.9" "475.9" "524.6" "453.6" "474.5" "537.3" "447.6" "477.5" "665.0" "562.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6229699224070924638" "False" "High" "IsMasterProtein" "Q13107" "Ubiquitin carboxyl-terminal hydrolase 4 OS=Homo sapiens OX=9606 GN=USP4 PE=1 SV=3" "0.000" "False" "74.962" "17" "16" "17" "13" "963" "108.5" "5.71" "56.13" "16" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14836" "7375" "ENSG00000114316" "USP4" "A8K6Y0; C9IY91; hsa:7375; O43452; O43453; Q08AK8; Q13107" "Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "" "4" "0" "1.014" "1.009" "0.925" "1.002" "1.013" "0.924" "0.953" "1.059" "1.033" "825.3" "836.9" "832.8" "763.3" "827.1" "835.9" "763.0" "786.8" "874.1" "852.6" "" "" "" "" "" "" "" "" "" "" "662.9" "603.9" "661.5" "511.4" "572.0" "627.2" "534.2" "574.6" "874.1" "693.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7316364973511523624" "False" "High" "IsMasterProtein" "Q8IYI6" "Exocyst complex component 8 OS=Homo sapiens OX=9606 GN=EXOC8 PE=1 SV=2" "0.000" "False" "74.955" "24" "16" "17" "16" "725" "81.7" "5.49" "60.52" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf08700, Pf16528" "149371" "ENSG00000116903" "EXOC8" "B3KU33; hsa:149371; Q5TE82; Q8IYI6" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "RalA downstream regulated genes; Ciliary landscape" "5" "0" "1.004" "1.002" "0.985" "0.996" "0.957" "0.972" "1.019" "1.003" "1.019" "1735.7" "1742.7" "1738.5" "1710.0" "1728.8" "1661.6" "1686.7" "1768.3" "1741.1" "1769.4" "" "" "" "" "" "" "" "" "" "" "1394.1" "1257.5" "1381.0" "1145.7" "1195.7" "1246.7" "1180.9" "1291.4" "1741.1" "1439.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814198643835656164" "False" "High" "IsMasterProtein" "O60711" "Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1" "0.000" "False" "74.838" "33" "9" "16" "9" "386" "43.3" "6.01" "58.72" "9" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "9404" "ENSG00000110031" "LPXN" "B2R8B4; B4DV71; hsa:9404; O60711; Q53FW6; Q6FI07" "" "" "0" "0" "0.924" "0.914" "0.790" "0.906" "0.998" "0.921" "0.968" "0.970" "0.951" "1490.3" "1377.2" "1361.7" "1177.8" "1350.6" "1488.0" "1372.8" "1442.8" "1446.1" "1417.1" "" "" "" "" "" "" "" "" "" "" "1197.0" "993.8" "1081.7" "789.1" "934.1" "1116.4" "961.1" "1053.7" "1446.1" "1152.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889177674351520658" "False" "High" "IsMasterProtein" "Q8ND24" "RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2" "0.000" "False" "74.792" "23" "14" "16" "14" "703" "77.6" "6.95" "60.28" "14" "" "" "other molecular function" "" "257160" "ENSG00000167257" "RNF214" "B2RUW0; B4DTD1; hsa:257160; Q8ND24" "" "" "0" "0" "1.040" "1.020" "1.085" "1.063" "1.030" "0.993" "1.009" "1.060" "1.064" "1229.5" "1278.7" "1254.6" "1333.6" "1307.2" "1266.3" "1221.2" "1240.3" "1302.9" "1307.9" "" "" "" "" "" "" "" "" "" "" "987.5" "922.6" "996.6" "893.5" "904.1" "950.1" "855.0" "905.8" "1302.9" "1063.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9201428938326541883" "False" "High" "IsMasterProtein" "Q15291" "Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2" "0.000" "False" "74.764" "25" "11" "17" "11" "538" "59.1" "5.10" "66.33" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00400" "5929" "ENSG00000117222" "RBBP5" "A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Kleefstra syndrome" "8" "0" "1.028" "0.983" "0.993" "1.066" "0.977" "1.039" "1.066" "1.153" "1.033" "2225.6" "2288.2" "2187.1" "2210.1" "2371.9" "2174.1" "2313.5" "2373.4" "2565.4" "2298.0" "" "" "" "" "" "" "" "" "" "" "1787.6" "1651.1" "1737.3" "1480.8" "1640.4" "1631.2" "1619.8" "1733.3" "2565.4" "1868.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3797665255168145849" "False" "High" "IsMasterProtein" "P46087" "28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2" "0.000" "False" "74.647" "15" "11" "16" "11" "812" "89.2" "9.23" "58.34" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf08062, Pf17125" "4839" "ENSG00000111641" "NOP2" "A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30" "rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "Imatinib and chronic myeloid leukemia" "3" "0" "1.009" "1.135" "1.138" "1.077" "1.086" "1.147" "1.077" "1.047" "1.092" "1273.1" "1284.8" "1444.9" "1448.7" "1370.7" "1382.8" "1460.1" "1371.6" "1333.4" "1390.2" "" "" "" "" "" "" "" "" "" "" "1022.6" "927.0" "1147.7" "970.6" "948.0" "1037.5" "1022.3" "1001.7" "1333.4" "1130.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245887775356859101" "False" "High" "IsMasterProtein" "Q8N0Z6" "Tetratricopeptide repeat protein 5 OS=Homo sapiens OX=9606 GN=TTC5 PE=1 SV=2" "0.000" "False" "74.485" "30" "11" "16" "11" "440" "48.9" "6.48" "55.48" "11" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf16669" "91875" "ENSG00000136319; ENSG00000291781" "TTC5" "A8MQ18; hsa:91875; Q8N0Z6; Q96HF9" "Regulation of TP53 Activity through Methylation" "" "1" "0" "1.021" "0.978" "1.048" "1.032" "0.998" "1.029" "1.052" "0.996" "1.031" "1222.7" "1248.4" "1195.9" "1281.3" "1261.9" "1219.8" "1257.6" "1286.2" "1218.1" "1260.6" "" "" "" "" "" "" "" "" "" "" "982.1" "900.8" "950.0" "858.5" "872.7" "915.2" "880.5" "939.3" "1218.1" "1025.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "882715983706929749" "False" "High" "IsMasterProtein" "Q9NZ08" "Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3" "0.000" "False" "74.472" "16" "15" "22" "15" "941" "107.2" "6.46" "69.32" "15" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01433, Pf11838, Pf17900" "51752" "ENSG00000164307" "ERAP1" "hsa:51752; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9NZ08; Q9UHF8; Q9UKY2" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "" "1" "0" "0.978" "0.969" "0.983" "1.021" "1.024" "0.978" "1.008" "0.990" "1.001" "2153.7" "2106.9" "2086.8" "2116.6" "2198.7" "2206.3" "2106.6" "2170.1" "2131.7" "2155.4" "" "" "" "" "" "" "" "" "" "" "1729.8" "1520.3" "1657.6" "1418.1" "1520.6" "1655.4" "1474.9" "1584.8" "2131.7" "1752.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3249613255715037073" "False" "High" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "0.000" "False" "74.395" "49" "10" "39" "10" "224" "25.0" "6.38" "118.48" "10" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "5" "0" "0.976" "0.969" "0.949" "0.907" "0.966" "0.900" "0.909" "0.909" "0.879" "2518.8" "2459.1" "2439.7" "2391.6" "2284.2" "2432.4" "2267.6" "2290.8" "2290.3" "2215.1" "" "" "" "" "" "" "" "" "" "" "2023.1" "1774.4" "1938.0" "1602.4" "1579.7" "1825.0" "1587.7" "1673.0" "2290.3" "1801.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4686891910023409545" "False" "High" "IsMasterProtein" "P62140" "Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3" "0.000" "False" "74.386" "39" "10" "26" "3" "327" "37.2" "6.19" "90.33" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5500" "ENSG00000213639" "PPP1CB" "B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45" "Triglyceride catabolism; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; RHO GTPases activate CIT; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway" "19" "0" "0.982" "0.944" "1.101" "1.078" "1.026" "1.055" "1.043" "1.061" "1.057" "349.5" "343.4" "329.9" "384.8" "376.6" "358.8" "368.9" "364.5" "370.7" "369.4" "" "" "" "" "" "" "" "" "" "" "280.8" "247.8" "262.1" "257.8" "260.5" "269.2" "258.3" "266.2" "370.7" "300.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5028999113090776511" "False" "High" "IsMasterProtein" "Q8WVB6" "Chromosome transmission fidelity protein 18 homolog OS=Homo sapiens OX=9606 GN=CHTF18 PE=1 SV=1" "0.000" "False" "74.379" "15" "11" "14" "10" "975" "107.3" "7.21" "54.07" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004" "63922" "ENSG00000127586" "CHTF18" "B7ZBA2; D3DU68; hsa:63922; Q7Z6Y4; Q7Z6Y6; Q8WVB6; Q9BR83; Q9BRG5; Q9H7K3" "Polymerase switching on the C-strand of the telomere" "Gastric cancer network 2; 7q11.23 copy number variation syndrome" "3" "1" "1.021" "1.024" "1.064" "1.020" "0.984" "1.046" "1.052" "1.003" "1.017" "628.9" "641.8" "643.8" "669.1" "641.7" "619.0" "657.9" "661.6" "630.6" "639.8" "" "" "" "" "" "" "" "" "" "" "505.1" "463.1" "511.4" "448.3" "443.8" "464.4" "460.6" "483.2" "630.6" "520.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8172346971524846949" "False" "High" "IsMasterProtein" "Q13126" "S-methyl-5'-thioadenosine phosphorylase OS=Homo sapiens OX=9606 GN=MTAP PE=1 SV=2" "0.000" "False" "74.331" "53" "11" "21" "11" "283" "31.2" "7.18" "70.40" "11" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01048" "4507" "ENSG00000099810" "MTAP" "hsa:4507; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0; Q13126; Q5T3P3; Q9H010" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Methionine salvage pathway" "Methionine de novo and salvage pathway" "3" "0" "1.033" "0.997" "1.056" "0.969" "0.951" "0.913" "0.889" "0.880" "0.956" "649.4" "670.6" "647.2" "685.8" "629.4" "617.5" "592.9" "577.6" "571.5" "620.6" "" "" "" "" "" "" "" "" "" "" "521.6" "483.9" "514.1" "459.5" "435.3" "463.3" "415.1" "421.8" "571.5" "504.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2260332764015544813" "False" "High" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "0.000" "False" "74.231" "15" "15" "20" "15" "1192" "132.5" "6.19" "75.13" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "Post-chaperonin tubulin folding pathway" "" "1" "0" "1.063" "1.073" "1.069" "1.031" "1.001" "1.020" "1.025" "1.020" "1.067" "2038.1" "2166.9" "2187.4" "2178.6" "2101.0" "2040.2" "2078.7" "2088.9" "2078.0" "2174.8" "" "" "" "" "" "" "" "" "" "" "1637.0" "1563.6" "1737.5" "1459.6" "1453.1" "1530.7" "1455.4" "1525.5" "2078.0" "1768.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6282846472165231546" "False" "High" "IsMasterProtein" "Q9P289" "Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2" "0.000" "False" "74.223" "36" "13" "25" "7" "416" "46.5" "5.29" "77.82" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "51765" "ENSG00000134602" "STK26" "B2RAU2; hsa:51765; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4; Q9P289" "Apoptotic cleavage of cellular proteins" "" "1" "6" "0.980" "1.020" "0.979" "0.986" "0.957" "0.932" "1.050" "0.977" "0.991" "3201.0" "3138.3" "3265.6" "3134.0" "3155.9" "3064.6" "2982.9" "3361.8" "3126.3" "3173.6" "" "" "" "" "" "" "" "" "" "" "2571.0" "2264.5" "2594.0" "2099.8" "2182.7" "2299.3" "2088.5" "2455.1" "3126.3" "2580.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6083245125138804483" "False" "High" "IsMasterProtein" "Q15027" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ACAP1 PE=1 SV=1" "0.000" "False" "74.176" "25" "13" "15" "13" "740" "81.5" "7.66" "51.95" "13" "transport" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00023, Pf00169, Pf01412, Pf16746" "9744" "ENSG00000072818; ENSG00000288169" "ACAP1" "hsa:9744; Q15027; Q53XN9" "" "Nucleotide-binding oligomerization domain (NOD) pathway" "1" "0" "0.928" "0.904" "1.020" "0.928" "0.921" "0.884" "0.885" "0.889" "1.007" "980.0" "909.4" "885.7" "999.7" "909.3" "902.4" "866.7" "867.3" "871.1" "987.0" "" "" "" "" "" "" "" "" "" "" "787.1" "656.2" "703.6" "669.8" "628.9" "677.1" "606.8" "633.4" "871.1" "802.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459435427997336669" "False" "High" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "0.000" "False" "74.101" "17" "17" "27" "16" "1041" "119.2" "6.80" "80.67" "17" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.020" "1.000" "1.026" "1.030" "0.994" "0.948" "0.995" "0.986" "0.985" "1654.6" "1687.4" "1655.2" "1697.3" "1704.5" "1644.9" "1568.9" "1645.7" "1632.2" "1629.2" "" "" "" "" "" "" "" "" "" "" "1329.0" "1217.6" "1314.8" "1137.2" "1178.9" "1234.2" "1098.4" "1201.8" "1632.2" "1324.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3257917255703740656" "False" "High" "IsMasterProtein" "Q14181" "DNA polymerase alpha subunit B OS=Homo sapiens OX=9606 GN=POLA2 PE=1 SV=2" "0.000" "False" "74.005" "25" "12" "18" "12" "598" "65.9" "5.24" "65.60" "12" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus" "nucleic acid binding activity" "Pf04042, Pf08418" "23649" "ENSG00000014138" "POLA2" "B4DNB4; hsa:23649; Q14181; Q9BPV3" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "12" "0" "1.040" "1.066" "1.096" "0.983" "1.027" "1.014" "1.069" "1.086" "1.034" "868.4" "902.8" "926.1" "951.6" "854.1" "891.7" "880.7" "928.6" "942.7" "898.3" "" "" "" "" "" "" "" "" "" "" "697.5" "651.4" "735.7" "637.6" "590.7" "669.0" "616.6" "678.2" "942.7" "730.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320563030437256339" "False" "High" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "0.000" "False" "73.984" "43" "10" "16" "10" "272" "28.2" "6.28" "61.59" "10" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "0.992" "0.978" "0.973" "1.092" "1.048" "0.945" "1.063" "1.068" "1.029" "1108.4" "1099.3" "1083.8" "1078.2" "1210.6" "1161.8" "1047.5" "1178.8" "1183.9" "1140.2" "" "" "" "" "" "" "" "" "" "" "890.2" "793.3" "860.9" "722.4" "837.3" "871.7" "733.4" "860.8" "1183.9" "927.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-216911938682189755" "False" "High" "IsMasterProtein" "Q27J81" "Inverted formin-2 OS=Homo sapiens OX=9606 GN=INF2 PE=1 SV=2" "0.000" "False" "73.979" "13" "14" "16" "14" "1249" "135.5" "5.38" "55.16" "14" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf02205, Pf06367, Pf06371" "64423" "ENSG00000203485" "INF2" "hsa:64423; Q27J81; Q27J83; Q69YL8; Q6P1X7; Q6PK22; Q86TR7; Q9BRM1; Q9H6N1" "" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "2" "0" "1.083" "1.022" "1.062" "0.952" "1.036" "1.030" "1.021" "1.078" "1.039" "984.8" "1066.7" "1006.8" "1046.4" "937.7" "1020.7" "1014.5" "1005.3" "1062.0" "1023.5" "" "" "" "" "" "" "" "" "" "" "791.0" "769.7" "799.7" "701.1" "648.5" "765.8" "710.3" "734.2" "1062.0" "832.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4306036841848923980" "False" "High" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "0.000" "False" "73.833" "40" "15" "22" "14" "370" "40.7" "7.21" "68.64" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "ESR-mediated signaling" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "4" "0" "1.027" "1.027" "1.039" "1.047" "1.014" "1.036" "1.080" "1.037" "1.013" "2534.2" "2602.1" "2603.8" "2633.0" "2653.8" "2569.5" "2625.2" "2737.8" "2628.4" "2567.2" "" "" "" "" "" "" "" "" "" "" "2035.4" "1877.6" "2068.3" "1764.1" "1835.4" "1927.8" "1838.0" "1999.5" "2628.4" "2087.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1398033593130895886" "False" "High" "IsMasterProtein" "O43264" "Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3" "0.000" "False" "73.793" "22" "14" "17" "14" "779" "88.8" "6.27" "58.25" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf06248, Pf20665, Pf20666" "9183" "ENSG00000086827" "ZW10" "A1A528; hsa:9183; O43264" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "1.004" "0.929" "0.995" "1.012" "0.964" "0.972" "1.032" "0.977" "0.991" "1498.0" "1504.1" "1392.3" "1491.1" "1515.3" "1444.1" "1456.3" "1545.5" "1462.8" "1485.0" "" "" "" "" "" "" "" "" "" "" "1203.1" "1085.3" "1106.0" "999.1" "1048.0" "1083.5" "1019.6" "1128.7" "1462.8" "1207.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372358057775812967" "False" "High" "IsMasterProtein" "Q9UMZ2" "Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2" "0.000" "False" "73.774" "11" "15" "19" "15" "1314" "140.6" "5.03" "58.04" "15" "transport" "other membranes;ER/Golgi;other cell component" "" "" "11276" "ENSG00000274047; ENSG00000275066" "SYNRG" "A8MWU4; B7ZKZ2; B7ZKZ3; hsa:11276; Q17RI2; Q5BKU5; Q6ZT17; Q9UMZ2" "" "17q12 copy number variation syndrome" "1" "0" "0.952" "0.950" "1.041" "0.979" "0.968" "1.018" "1.013" "0.993" "0.940" "1458.2" "1387.7" "1385.6" "1517.7" "1427.2" "1411.0" "1483.9" "1477.6" "1448.6" "1371.0" "" "" "" "" "" "" "" "" "" "" "1171.2" "1001.3" "1100.6" "1016.8" "987.0" "1058.6" "1039.0" "1079.1" "1448.6" "1115.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494116660910275017" "False" "High" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "0.000" "False" "73.748" "31" "9" "16" "9" "394" "44.4" "5.40" "68.72" "9" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "" "2" "0" "1.047" "1.052" "1.022" "1.001" "1.107" "1.058" "1.092" "1.099" "1.064" "718.1" "751.7" "755.6" "734.2" "719.0" "795.0" "759.7" "783.9" "789.4" "763.8" "" "" "" "" "" "" "" "" "" "" "576.8" "542.4" "600.2" "491.9" "497.3" "596.5" "531.9" "572.5" "789.4" "621.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2946380844768102927" "False" "High" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "0.000" "False" "73.663" "32" "19" "34" "14" "572" "61.6" "8.38" "98.74" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "1.014" "1.028" "1.059" "0.992" "0.958" "0.971" "0.996" "0.989" "1.018" "2109.3" "2138.1" "2168.3" "2234.2" "2091.7" "2020.9" "2047.3" "2100.1" "2087.0" "2147.5" "" "" "" "" "" "" "" "" "" "" "1694.1" "1542.8" "1722.4" "1496.9" "1446.7" "1516.3" "1433.4" "1533.7" "2087.0" "1746.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5381217781487520932" "False" "High" "IsMasterProtein" "Q99536" "Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2" "0.000" "False" "73.572" "35" "7" "12" "7" "393" "41.9" "6.29" "52.18" "7" "other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf08240, Pf13602" "10493" "ENSG00000108828" "VAT1" "A8K345; B0AZP7; B4DPX4; hsa:10493; Q13035; Q5BKZ7; Q96A39; Q99536; Q9BUT8" "Neutrophil degranulation" "" "1" "0" "1.053" "0.963" "1.027" "1.014" "1.010" "1.055" "1.017" "1.028" "1.031" "966.4" "1017.8" "930.9" "992.0" "979.6" "975.6" "1019.2" "982.9" "993.6" "995.9" "" "" "" "" "" "" "" "" "" "" "776.2" "734.4" "739.5" "664.6" "677.5" "731.9" "713.6" "717.8" "993.6" "809.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2236702861585061595" "False" "High" "IsMasterProtein" "P57721" "Poly(rC)-binding protein 3 OS=Homo sapiens OX=9606 GN=PCBP3 PE=1 SV=2" "0.000" "False" "73.559" "20" "6" "33" "1" "371" "39.4" "8.07" "105.96" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity" "Pf00013, Pf07650" "54039" "ENSG00000183570" "PCBP3" "A8MPS2; A8MQ26; B7WNN9; B7WPC1; P57721; Q8N9K6; Q96EP6" "" "" "0" "0" "0.833" "0.807" "0.837" "0.833" "0.900" "0.932" "0.878" "0.891" "0.891" "215.3" "179.4" "173.7" "180.2" "179.4" "193.7" "200.7" "189.1" "191.9" "191.9" "" "" "" "" "" "" "" "" "" "" "172.9" "129.4" "138.0" "120.7" "124.1" "145.3" "140.5" "138.1" "191.9" "156.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5275540959932174837" "False" "High" "IsMasterProtein" "Q14847" "LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2" "0.000" "False" "73.547" "43" "11" "35" "11" "261" "29.7" "7.05" "108.49" "11" "transport" "cytoskeleton;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00412, Pf00880, Pf14604" "3927" "ENSG00000002834" "LASP1" "B4DGQ0; hsa:3927; Q14847; Q96ED2; Q96IG0" "" "17q12 copy number variation syndrome" "1" "0" "1.024" "0.998" "1.043" "1.038" "1.060" "1.075" "1.053" "1.059" "1.025" "2182.5" "2234.2" "2179.2" "2275.7" "2264.6" "2312.5" "2345.7" "2299.0" "2311.0" "2237.7" "" "" "" "" "" "" "" "" "" "" "1753.0" "1612.1" "1731.0" "1524.7" "1566.2" "1735.0" "1642.3" "1679.0" "2311.0" "1819.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7997158032231502372" "False" "High" "IsMasterProtein" "Q9Y6D9" "Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2" "0.000" "False" "73.539" "24" "17" "22" "17" "718" "83.0" "5.92" "68.13" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05557" "8379" "ENSG00000002822" "MAD1L1" "B3KR41; hsa:8379; Q13312; Q75MI0; Q86UM4; Q9UNH0; Q9Y6D9" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma; CCL18 signaling pathway" "10" "0" "1.035" "1.005" "1.042" "1.017" "0.901" "0.969" "0.940" "1.036" "1.027" "632.3" "654.5" "635.6" "659.0" "642.8" "570.0" "612.5" "594.3" "654.8" "649.2" "" "" "" "" "" "" "" "" "" "" "507.9" "472.2" "504.9" "441.5" "444.6" "427.7" "428.8" "434.0" "654.8" "527.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6144698658960758490" "False" "High" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "0.000" "False" "73.520" "13" "10" "18" "10" "793" "91.0" "7.18" "60.23" "10" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "0.915" "0.905" "0.935" "1.041" "1.026" "1.008" "1.037" "0.972" "0.987" "1282.4" "1173.6" "1160.0" "1199.5" "1334.4" "1315.5" "1292.1" "1330.4" "1246.5" "1266.4" "" "" "" "" "" "" "" "" "" "" "1030.0" "846.8" "921.4" "803.7" "922.9" "987.0" "904.7" "971.6" "1246.5" "1029.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2095194651549531862" "False" "High" "IsMasterProtein" "O95487" "Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2" "0.000" "False" "73.450" "12" "12" "19" "10" "1268" "137.3" "6.67" "56.83" "12" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10427" "ENSG00000138802" "SEC24B" "B7ZKM8; B7ZKN4; hsa:10427; O95487; Q0VG08" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "1.062" "0.988" "1.091" "1.087" "0.966" "1.080" "1.009" "0.930" "1.031" "330.1" "350.6" "326.1" "360.3" "358.9" "318.7" "356.6" "333.0" "306.9" "340.2" "" "" "" "" "" "" "" "" "" "" "265.1" "253.0" "259.0" "241.4" "248.2" "239.1" "249.6" "243.2" "306.9" "276.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3101677286908017403" "False" "High" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "0.000" "False" "73.409" "24" "14" "19" "14" "684" "75.4" "6.61" "62.16" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "1.013" "1.004" "1.029" "0.948" "1.001" "0.949" "0.978" "1.022" "0.998" "1084.9" "1099.2" "1088.9" "1116.4" "1028.0" "1086.0" "1029.1" "1061.1" "1109.0" "1082.5" "" "" "" "" "" "" "" "" "" "" "871.4" "793.2" "864.9" "748.0" "711.0" "814.8" "720.5" "774.9" "1109.0" "880.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100681429736934038" "False" "High" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "0.000" "False" "73.377" "34" "10" "15" "10" "330" "37.4" "10.01" "48.24" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "1.045" "0.934" "0.957" "0.902" "0.956" "0.939" "0.953" "0.920" "0.965" "973.1" "1016.5" "908.8" "931.2" "877.4" "930.6" "913.6" "927.7" "895.1" "938.6" "" "" "" "" "" "" "" "" "" "" "781.6" "733.5" "721.9" "623.9" "606.8" "698.2" "639.6" "677.5" "895.1" "763.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838568104168178339" "False" "High" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "0.000" "False" "73.340" "27" "12" "22" "12" "463" "51.8" "5.45" "78.07" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "Hijack of ubiquitination by SARS-CoV-2" "5" "0" "1.048" "0.987" "1.017" "0.999" "1.016" "1.003" "0.940" "0.948" "1.014" "2097.2" "2198.6" "2069.3" "2132.3" "2095.7" "2130.9" "2102.5" "1971.2" "1988.8" "2126.2" "" "" "" "" "" "" "" "" "" "" "1684.4" "1586.5" "1643.7" "1428.6" "1449.4" "1598.8" "1472.0" "1439.6" "1988.8" "1729.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209519133895389976" "False" "High" "IsMasterProtein" "Q9P107" "GEM-interacting protein OS=Homo sapiens OX=9606 GN=GMIP PE=1 SV=2" "0.000" "False" "73.317" "18" "14" "16" "14" "970" "106.6" "5.72" "57.09" "14" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00620" "51291" "ENSG00000089639" "GMIP" "A0AVN9; B7ZLZ0; hsa:51291; Q9P107" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "" "3" "0" "1.069" "0.953" "1.076" "0.949" "0.949" "0.985" "1.040" "1.008" "1.019" "638.7" "682.6" "609.0" "687.5" "606.4" "605.9" "629.3" "664.1" "643.8" "651.0" "" "" "" "" "" "" "" "" "" "" "513.0" "492.5" "483.7" "460.6" "419.4" "454.6" "440.6" "485.0" "643.8" "529.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634155616669097337" "False" "High" "IsMasterProtein" "P42768" "Actin nucleation-promoting factor WAS OS=Homo sapiens OX=9606 GN=WAS PE=1 SV=4" "0.000" "False" "73.221" "22" "9" "18" "9" "502" "52.9" "6.64" "63.56" "9" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00568, Pf00786, Pf02205" "7454" "ENSG00000015285" "WAS" "hsa:7454; P42768; Q9BU11; Q9UNJ9" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Generation of second messenger molecules; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle" "Pathogenic Escherichia coli infection; Complement system; Chemokine signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor signaling pathway" "13" "0" "0.991" "1.017" "0.998" "1.079" "1.006" "1.010" "1.040" "1.039" "1.062" "1617.4" "1602.8" "1644.7" "1613.4" "1744.9" "1627.0" "1633.7" "1682.9" "1680.1" "1718.4" "" "" "" "" "" "" "" "" "" "" "1299.1" "1156.6" "1306.5" "1081.0" "1206.8" "1220.7" "1143.8" "1229.0" "1680.1" "1397.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8263203131680576726" "False" "High" "IsMasterProtein" "Cont_P13717" "Nuclease OS=Serratia marcescens OX=615 GN=nucA PE=1 SV=2" "0.000" "True" "73.166" "36" "9" "20" "9" "266" "28.9" "7.42" "71.89" "9" "" "non-structural extracellular" "nucleic acid binding activity;other molecular function" "Pf01223" "66715254" "" "nucA" "A0A2V4G0H5; A0A5C7C9X8; A0A656VIL2; P13717" "" "" "0" "0" "0.910" "0.892" "1.041" "1.127" "1.040" "1.250" "0.963" "1.042" "1.045" "1815.7" "1652.6" "1619.0" "1889.9" "2046.5" "1887.8" "2270.0" "1748.2" "1892.3" "1897.1" "" "" "" "" "" "" "" "" "" "" "1458.4" "1192.5" "1286.0" "1266.2" "1415.4" "1416.4" "1589.3" "1276.7" "1892.3" "1542.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6030770174415932169" "False" "High" "IsMasterProtein" "P52294" "Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3" "0.000" "False" "73.131" "19" "10" "18" "5" "538" "60.2" "5.01" "71.62" "10" "cell-cell signaling;cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3836" "ENSG00000114030" "KPNA1" "D3DN93; hsa:3836; P52294; Q6IBQ9; Q9BQ56" "Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Interferon alpha/beta signaling; Assembly of the ORC complex at the origin of replication; Integration of provirus; Inhibition of nitric oxide production" "Ebola virus infection in host" "10" "4" "1.060" "1.015" "1.027" "0.940" "0.984" "0.922" "1.015" "0.987" "1.006" "1549.0" "1641.4" "1572.8" "1590.4" "1456.1" "1524.6" "1428.1" "1571.6" "1528.4" "1558.2" "" "" "" "" "" "" "" "" "" "" "1244.2" "1184.4" "1249.3" "1065.6" "1007.1" "1143.9" "999.9" "1147.8" "1528.4" "1267.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8048199414682788645" "False" "High" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "0.000" "False" "73.056" "45" "11" "25" "11" "249" "28.7" "6.02" "70.56" "11" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "0.919" "0.909" "0.901" "0.856" "1.003" "0.927" "0.838" "0.944" "0.925" "2395.9" "2201.5" "2177.1" "2158.5" "2052.1" "2402.5" "2220.5" "2008.9" "2260.7" "2216.1" "" "" "" "" "" "" "" "" "" "" "1924.4" "1588.5" "1729.3" "1446.2" "1419.2" "1802.6" "1554.7" "1467.1" "2260.7" "1802.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077624206486076316" "False" "High" "IsMasterProtein" "Q8TC07" "TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2" "0.000" "False" "73.034" "22" "15" "22" "15" "691" "79.4" "5.67" "72.21" "15" "other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00566, Pf12068" "64786" "ENSG00000121749" "TBC1D15" "B4DMT9; B9A6L6; hsa:64786; J3KNI9; Q8TC07; Q9HA83" "TBC/RABGAPs" "" "1" "0" "1.000" "0.998" "0.973" "0.951" "0.966" "0.912" "1.007" "0.964" "1.012" "1572.5" "1572.7" "1570.1" "1529.9" "1495.5" "1519.8" "1433.5" "1582.8" "1516.3" "1591.2" "" "" "" "" "" "" "" "" "" "" "1263.0" "1134.8" "1247.1" "1025.1" "1034.3" "1140.3" "1003.7" "1155.9" "1516.3" "1294.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5219962160653880547" "False" "High" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "0.000" "False" "72.991" "43" "12" "21" "12" "309" "34.5" "8.98" "68.53" "12" "other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "1.052" "1.037" "1.024" "1.005" "1.045" "0.973" "1.018" "1.052" "1.034" "1152.5" "1212.2" "1195.0" "1180.5" "1158.5" "1204.1" "1120.8" "1173.0" "1211.9" "1191.7" "" "" "" "" "" "" "" "" "" "" "925.7" "874.7" "949.3" "791.0" "801.2" "903.4" "784.7" "856.6" "1211.9" "969.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871299150167349072" "False" "High" "IsMasterProtein" "Q8TF68" "Zinc finger protein 384 OS=Homo sapiens OX=9606 GN=ZNF384 PE=1 SV=2" "0.000" "False" "72.986" "26" "11" "16" "11" "577" "63.2" "8.95" "59.63" "11" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "171017" "ENSG00000126746" "ZNF384" "hsa:171017; O15407; Q7Z722; Q8N938; Q8TF68" "" "" "0" "0" "1.059" "1.063" "1.066" "1.104" "1.120" "1.030" "1.006" "1.108" "1.088" "1026.9" "1087.1" "1091.9" "1094.4" "1133.7" "1150.2" "1057.3" "1032.6" "1137.4" "1117.6" "" "" "" "" "" "" "" "" "" "" "824.8" "784.4" "867.3" "733.2" "784.1" "862.9" "740.3" "754.1" "1137.4" "908.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-796628633734857382" "False" "High" "IsMasterProtein" "Q13439" "Golgin subfamily A member 4 OS=Homo sapiens OX=9606 GN=GOLGA4 PE=1 SV=1" "0.000" "False" "72.937" "8" "20" "24" "19" "2230" "261.0" "5.39" "77.41" "20" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01465" "2803" "ENSG00000144674" "GOLGA4" "F8W8Q7; hsa:2803; Q13270; Q13439; Q13654; Q14436; Q59EW8" "Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "" "2" "0" "0.995" "0.986" "1.007" "0.924" "0.944" "0.882" "0.877" "0.934" "1.004" "1148.9" "1143.1" "1132.7" "1157.4" "1061.1" "1084.5" "1013.5" "1007.1" "1072.7" "1153.1" "" "" "" "" "" "" "" "" "" "" "922.8" "824.8" "899.7" "775.5" "733.9" "813.6" "709.6" "735.5" "1072.7" "937.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2007854671863603578" "False" "High" "IsMasterProtein" "P46734" "Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2" "0.000" "False" "72.855" "33" "10" "19" "6" "347" "39.3" "7.43" "68.64" "10" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5606" "ENSG00000034152" "MAP2K3" "B3KSK7; hsa:5606; P46734; Q99441; Q9UE71; Q9UE72" "Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Endoderm differentiation; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "34" "4" "1.035" "1.020" "0.966" "1.057" "1.030" "1.045" "1.011" "1.067" "1.034" "1150.9" "1191.7" "1173.4" "1112.1" "1217.1" "1185.3" "1202.8" "1163.4" "1228.4" "1189.7" "" "" "" "" "" "" "" "" "" "" "924.4" "859.9" "932.1" "745.1" "841.7" "889.3" "842.1" "849.6" "1228.4" "967.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241628752191747033" "False" "High" "IsMasterProtein" "Q9Y6W3" "Calpain-7 OS=Homo sapiens OX=9606 GN=CAPN7 PE=1 SV=1" "0.000" "False" "72.832" "19" "13" "15" "13" "813" "92.6" "7.65" "59.82" "13" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00648, Pf01067, Pf04212" "23473" "ENSG00000131375" "CAPN7" "hsa:23473; Q9Y6W3" "Degradation of the extracellular matrix" "Integrin-mediated cell adhesion" "2" "0" "1.012" "1.009" "0.993" "0.982" "1.009" "0.965" "0.962" "0.997" "1.016" "1562.4" "1580.5" "1576.8" "1550.8" "1533.5" "1576.7" "1507.1" "1502.8" "1558.2" "1587.0" "" "" "" "" "" "" "" "" "" "" "1254.9" "1140.4" "1252.5" "1039.1" "1060.6" "1183.0" "1055.2" "1097.5" "1558.2" "1290.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8643593738164187642" "False" "High" "IsMasterProtein" "Q9H6S0" "3'-5' RNA helicase YTHDC2 OS=Homo sapiens OX=9606 GN=YTHDC2 PE=1 SV=2" "0.000" "False" "72.779" "11" "14" "18" "14" "1430" "160.1" "8.40" "59.14" "14" "cell cycle OR cell proliferation;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf00270, Pf00271, Pf01424, Pf04146, Pf04408, Pf07717, Pf21010" "64848" "ENSG00000047188" "YTHDC2" "B2RP66; hsa:64848; Q9H6S0" "" "" "0" "0" "1.069" "1.044" "1.116" "1.075" "1.002" "0.990" "1.048" "0.985" "1.036" "881.1" "941.7" "920.1" "982.9" "947.3" "882.8" "872.6" "923.6" "867.7" "912.7" "" "" "" "" "" "" "" "" "" "" "707.7" "679.5" "730.9" "658.6" "655.2" "662.4" "610.9" "674.5" "867.7" "742.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296645769357171248" "False" "High" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "0.000" "False" "72.656" "29" "14" "23" "14" "582" "66.9" "9.55" "75.78" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.009" "1.008" "1.038" "1.023" "0.954" "0.990" "1.014" "0.912" "1.014" "1536.5" "1550.4" "1548.7" "1594.7" "1571.8" "1465.3" "1521.8" "1557.3" "1401.8" "1558.3" "" "" "" "" "" "" "" "" "" "" "1234.1" "1118.7" "1230.2" "1068.5" "1087.1" "1099.4" "1065.5" "1137.3" "1401.8" "1267.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120451514636770754" "False" "High" "IsMasterProtein" "Q12979" "Active breakpoint cluster region-related protein OS=Homo sapiens OX=9606 GN=ABR PE=1 SV=2" "0.000" "False" "72.629" "21" "16" "18" "14" "859" "97.5" "6.55" "65.49" "16" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00168, Pf00620, Pf00621" "29" "ENSG00000159842; ENSG00000276016; ENSG00000278741" "ABR" "B3KW89; B7Z6H7; D3DTH3; D3DTH4; F5H3S2; F5H8B3; hsa:29; Q12979; Q13693; Q13694" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle" "" "9" "1" "1.060" "1.050" "1.023" "1.006" "0.998" "0.960" "1.025" "1.003" "0.994" "1519.7" "1611.6" "1595.9" "1555.2" "1528.4" "1516.8" "1458.6" "1557.0" "1524.3" "1511.2" "" "" "" "" "" "" "" "" "" "" "1220.6" "1162.9" "1267.7" "1042.0" "1057.1" "1138.0" "1021.3" "1137.1" "1524.3" "1228.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178646061152564690" "False" "High" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "0.000" "False" "72.624" "38" "10" "14" "10" "356" "40.5" "8.34" "58.35" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "PCNA-Dependent Long Patch Base Excision Repair; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "1.038" "1.036" "1.009" "0.990" "0.972" "0.969" "1.095" "1.005" "1.046" "977.1" "1014.1" "1012.3" "986.1" "967.3" "949.7" "947.3" "1069.9" "982.0" "1021.8" "" "" "" "" "" "" "" "" "" "" "784.8" "731.7" "804.1" "660.7" "669.0" "712.6" "663.2" "781.4" "982.0" "831.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454508349601298395" "False" "High" "IsMasterProtein" "Q99447" "Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1" "0.000" "False" "72.568" "34" "13" "22" "13" "389" "43.8" "6.92" "74.75" "13" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01467" "5833" "ENSG00000185813" "PCYT2" "B7Z7A5; B7ZAS0; F5H8B1; hsa:5833; Q6IBM3; Q96G08; Q99447" "Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "5" "0" "0.986" "0.981" "0.984" "1.000" "0.998" "0.978" "1.014" "1.009" "0.981" "1431.8" "1411.2" "1404.7" "1408.9" "1431.8" "1429.2" "1399.6" "1451.5" "1445.0" "1404.7" "" "" "" "" "" "" "" "" "" "" "1150.0" "1018.3" "1115.8" "943.9" "990.3" "1072.3" "979.9" "1060.0" "1445.0" "1142.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3509057874585176951" "False" "High" "IsMasterProtein" "Q9GZS1" "DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3" "0.000" "False" "72.558" "33" "12" "22" "12" "419" "47.2" "8.94" "70.57" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06870" "64425" "ENSG00000137054" "POLR1E" "hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "9" "0" "1.041" "1.027" "1.005" "1.006" "0.984" "0.975" "1.022" "0.984" "1.016" "1870.2" "1946.0" "1920.0" "1879.3" "1881.8" "1841.1" "1823.6" "1910.6" "1839.5" "1899.7" "" "" "" "" "" "" "" "" "" "" "1502.1" "1404.2" "1525.1" "1259.2" "1301.5" "1381.4" "1276.8" "1395.4" "1839.5" "1544.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6065007746744177820" "False" "High" "IsMasterProtein" "Q9ULZ2" "Signal-transducing adaptor protein 1 OS=Homo sapiens OX=9606 GN=STAP1 PE=1 SV=1" "0.000" "False" "72.551" "38" "11" "23" "11" "295" "34.3" "7.77" "79.82" "11" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00169" "26228" "ENSG00000035720" "STAP1" "B2R980; hsa:26228; Q9ULZ2" "" "" "0" "0" "1.021" "1.000" "0.974" "0.960" "0.951" "0.969" "0.985" "0.957" "0.948" "2968.7" "3030.6" "2969.2" "2891.7" "2850.8" "2824.5" "2875.8" "2924.3" "2839.7" "2813.9" "" "" "" "" "" "" "" "" "" "" "2384.5" "2186.8" "2358.5" "1937.5" "1971.6" "2119.2" "2013.5" "2135.6" "2839.7" "2288.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110306690791428834" "False" "High" "IsMasterProtein" "P29218" "Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1" "0.000" "False" "72.525" "38" "8" "14" "8" "277" "30.2" "5.26" "54.48" "8" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf00459" "3612" "ENSG00000133731" "IMPA1" "B2R733; B4DLN3; B7Z6Q4; J3KQT7; P29218; Q9UK71" "Synthesis of IP2, IP, and Ins in the cytosol" "" "1" "0" "0.978" "0.997" "0.957" "0.965" "1.000" "0.912" "0.927" "0.934" "0.930" "863.2" "843.9" "860.8" "826.2" "832.9" "863.3" "787.3" "799.9" "806.4" "802.4" "" "" "" "" "" "" "" "" "" "" "693.3" "608.9" "683.8" "553.6" "576.1" "647.7" "551.2" "584.2" "806.4" "652.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459362278607736604" "False" "High" "IsMasterProtein" "Q9HB07" "MYG1 exonuclease OS=Homo sapiens OX=9606 GN=MYG1 PE=1 SV=4" "0.000" "False" "72.520" "32" "9" "18" "9" "376" "42.5" "6.84" "61.84" "9" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03690" "60314" "ENSG00000139637; ENSG00000291835" "MYG1" "hsa:60314; Q86UA3; Q9HB07" "" "" "0" "0" "0.985" "0.986" "1.002" "0.994" "0.945" "0.969" "0.956" "0.954" "0.980" "1372.0" "1351.8" "1352.6" "1375.3" "1364.4" "1297.0" "1329.6" "1311.1" "1308.8" "1344.7" "" "" "" "" "" "" "" "" "" "" "1102.0" "975.4" "1074.4" "921.4" "943.6" "973.1" "930.9" "957.5" "1308.8" "1093.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6922732359213996073" "False" "High" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "0.000" "False" "72.492" "15" "14" "18" "14" "1026" "117.3" "5.55" "65.21" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "1.029" "1.001" "1.008" "0.955" "0.964" "0.880" "1.043" "1.034" "1.029" "1179.7" "1214.1" "1181.1" "1189.3" "1127.1" "1137.0" "1038.5" "1230.4" "1219.3" "1213.9" "" "" "" "" "" "" "" "" "" "" "947.5" "876.0" "938.2" "796.9" "779.5" "853.1" "727.1" "898.6" "1219.3" "987.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1626409123411173154" "False" "High" "IsMasterProtein" "Q99598" "Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1" "0.000" "False" "72.484" "58" "14" "23" "14" "290" "33.1" "6.55" "69.49" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01997" "7257" "ENSG00000116918" "TSNAX" "B1APC6; hsa:7257; Q99598" "Small interfering RNA (siRNA) biogenesis" "" "1" "0" "0.978" "1.074" "1.006" "0.965" "1.020" "0.964" "0.908" "1.002" "0.988" "2375.7" "2323.0" "2551.1" "2389.3" "2292.1" "2423.3" "2289.6" "2158.2" "2379.4" "2347.6" "" "" "" "" "" "" "" "" "" "" "1908.2" "1676.2" "2026.4" "1600.9" "1585.2" "1818.1" "1603.0" "1576.1" "2379.4" "1909.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3163667791895929702" "False" "High" "IsMasterProtein" "Q63ZY3" "KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KANK2 PE=1 SV=1" "0.000" "False" "72.282" "20" "15" "24" "14" "851" "91.1" "5.63" "74.12" "15" "cell organization and biogenesis;developmental processes;other biological processes" "mitochondrion;other cell component" "" "Pf12075, Pf12796" "25959" "ENSG00000197256" "KANK2" "B0I1P4; hsa:25959; Q3KQZ3; Q63ZY3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210" "" "" "0" "0" "1.125" "1.031" "1.133" "1.144" "1.067" "1.442" "1.420" "1.397" "1.166" "981.5" "1104.2" "1012.2" "1112.4" "1122.4" "1047.3" "1415.2" "1394.0" "1370.9" "1144.7" "" "" "" "" "" "" "" "" "" "" "788.4" "796.7" "804.0" "745.3" "776.3" "785.8" "990.9" "1018.0" "1370.9" "930.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550232429458165552" "False" "High" "IsMasterProtein" "Q9NRZ9" "Lymphoid-specific helicase OS=Homo sapiens OX=9606 GN=HELLS PE=1 SV=1" "0.000" "False" "72.260" "21" "16" "25" "15" "838" "97.0" "7.93" "75.38" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "3070" "ENSG00000119969" "HELLS" "B2RB41; hsa:3070; Q3LID1; Q6I7N7; Q76H76; Q76H77; Q76H78; Q76H79; Q76H80; Q76H81; Q7Z397; Q7Z5X2; Q8N6P4; Q9H4P5; Q9NRZ9" "" "Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer" "2" "1" "1.173" "1.079" "1.101" "1.089" "1.057" "1.125" "1.227" "1.310" "1.114" "1452.4" "1704.4" "1567.1" "1599.6" "1582.1" "1534.5" "1633.9" "1781.9" "1903.1" "1618.5" "" "" "" "" "" "" "" "" "" "" "1166.6" "1229.8" "1244.8" "1071.8" "1094.2" "1151.3" "1144.0" "1301.3" "1903.1" "1316.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841386405994122390" "False" "High" "IsMasterProtein" "Q92785" "Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2" "0.000" "False" "72.177" "27" "9" "17" "9" "391" "44.1" "6.33" "48.07" "9" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "5977" "ENSG00000133884" "DPF2" "A8K7C9; B4DT58; hsa:5977; Q92785" "" "Tumor suppressor activity of SMARCB1" "1" "0" "1.187" "1.114" "1.091" "1.094" "1.085" "1.119" "1.133" "1.190" "1.153" "618.5" "734.4" "688.9" "674.7" "676.3" "671.3" "692.1" "700.9" "736.0" "713.1" "" "" "" "" "" "" "" "" "" "" "496.8" "529.9" "547.2" "452.0" "467.7" "503.7" "484.6" "511.8" "736.0" "579.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017068245716453317" "False" "High" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "0.000" "False" "72.173" "19" "17" "27" "11" "977" "107.5" "7.03" "84.05" "17" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "21" "5" "1.032" "0.995" "1.083" "1.072" "1.029" "1.125" "1.091" "1.104" "1.052" "1584.5" "1635.4" "1576.9" "1715.9" "1697.9" "1629.7" "1782.3" "1728.1" "1748.5" "1666.2" "" "" "" "" "" "" "" "" "" "" "1272.6" "1180.1" "1252.6" "1149.6" "1174.3" "1222.7" "1247.9" "1262.0" "1748.5" "1355.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3632960594176974073" "False" "High" "IsMasterProtein" "Q9UPN9" "E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3" "0.000" "False" "72.156" "11" "12" "18" "12" "1127" "122.5" "6.67" "66.36" "12" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf00643" "51592" "ENSG00000197323" "TRIM33" "hsa:51592; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79; Q9UPN9" "Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation" "Ectoderm differentiation" "3" "0" "1.025" "0.978" "0.982" "0.950" "0.948" "0.988" "1.006" "1.093" "0.993" "1761.8" "1805.7" "1722.9" "1730.7" "1673.3" "1670.8" "1740.3" "1772.5" "1925.8" "1749.2" "" "" "" "" "" "" "" "" "" "" "1415.0" "1303.0" "1368.5" "1159.6" "1157.3" "1253.5" "1218.4" "1294.4" "1925.8" "1422.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4612502200950371664" "False" "High" "IsMasterProtein" "Q86V21" "Acetoacetyl-CoA synthetase OS=Homo sapiens OX=9606 GN=AACS PE=1 SV=1" "0.000" "False" "72.154" "20" "14" "16" "14" "672" "75.1" "6.24" "55.92" "14" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00501, Pf16177" "65985" "ENSG00000081760" "AACS" "hsa:65985; Q49AB9; Q49AC3; Q658Q8; Q86V21; Q8IWD2; Q8NEW5; Q9BSJ9; Q9H829; Q9HA19" "Synthesis of Ketone Bodies" "" "1" "0" "1.012" "0.982" "0.981" "0.982" "1.018" "0.955" "0.958" "0.943" "0.990" "2756.7" "2789.2" "2707.9" "2703.7" "2707.0" "2805.1" "2633.9" "2642.1" "2598.8" "2730.3" "" "" "" "" "" "" "" "" "" "" "2214.2" "2012.6" "2151.0" "1811.5" "1872.2" "2104.6" "1844.1" "1929.5" "2598.8" "2220.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1449875230825116072" "False" "High" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "0.000" "False" "72.139" "27" "16" "22" "14" "620" "69.9" "5.59" "74.96" "16" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "6" "0" "1.033" "0.967" "1.053" "1.096" "1.076" "1.088" "1.061" "1.132" "1.040" "1405.7" "1452.1" "1359.8" "1479.9" "1541.0" "1512.9" "1529.1" "1492.0" "1591.4" "1462.2" "" "" "" "" "" "" "" "" "" "" "1129.0" "1047.8" "1080.2" "991.5" "1065.7" "1135.1" "1070.6" "1089.6" "1591.4" "1189.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9196998486354008360" "False" "High" "IsMasterProtein" "Q6F5E8" "Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2" "0.000" "False" "72.064" "11" "12" "15" "12" "1435" "154.6" "6.76" "55.30" "12" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13516, Pf16000, Pf17888" "146206" "ENSG00000159753" "CARMIL2" "B8X2Z3; hsa:146206; Q6F5E8" "" "" "0" "0" "1.098" "1.002" "1.145" "1.050" "1.026" "1.114" "1.085" "1.036" "1.093" "923.8" "1014.7" "925.5" "1057.4" "970.1" "947.7" "1029.5" "1002.2" "957.5" "1009.7" "" "" "" "" "" "" "" "" "" "" "742.0" "732.2" "735.2" "708.4" "670.9" "711.0" "720.8" "731.9" "957.5" "821.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8782574511401724651" "False" "High" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "0.000" "False" "72.063" "32" "17" "20" "17" "593" "68.0" "7.30" "59.44" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "PIP3 activates AKT signaling; GPVI-mediated activation cascade; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PD-1 signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Signal regulatory protein family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-3, Interleukin-5 and GM-CSF signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; PI3K Cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; Platelet sensitization by LDL; PECAM1 interactions; CTLA4 inhibitory signaling; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "91" "0" "0.979" "0.964" "1.008" "0.980" "1.025" "1.006" "1.025" "0.966" "1.028" "1603.9" "1570.2" "1546.4" "1616.3" "1572.6" "1644.8" "1614.4" "1643.3" "1549.4" "1648.7" "" "" "" "" "" "" "" "" "" "" "1288.3" "1133.0" "1228.4" "1082.9" "1087.6" "1234.1" "1130.3" "1200.1" "1549.4" "1340.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813032805198607075" "False" "High" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "0.000" "False" "72.030" "30" "11" "25" "6" "429" "49.4" "6.81" "74.30" "11" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "" "22q11.2 copy number variation syndrome" "1" "0" "0.954" "0.935" "0.931" "0.952" "0.987" "0.994" "1.006" "0.979" "0.941" "644.5" "615.0" "602.6" "600.2" "613.7" "636.0" "640.9" "648.5" "631.1" "606.8" "" "" "" "" "" "" "" "" "" "" "517.7" "443.8" "478.7" "402.1" "424.4" "477.2" "448.7" "473.6" "631.1" "493.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858767456070720034" "False" "High" "IsMasterProtein" "P55735" "Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3" "0.000" "False" "71.973" "41" "11" "19" "11" "322" "35.5" "5.48" "66.50" "11" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "6396" "ENSG00000157020" "SEC13" "A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7" "ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Separation of Sister Chromatids; HCMV Late Events; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPII-mediated vesicle transport; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Postmitotic nuclear pore complex (NPC) reformation" "Sterol regulatory element-binding proteins (SREBP) signaling" "40" "0" "1.001" "0.992" "1.051" "1.002" "1.064" "0.993" "1.071" "1.028" "1.022" "1796.8" "1799.2" "1781.8" "1888.2" "1800.0" "1912.7" "1784.4" "1925.2" "1846.3" "1837.1" "" "" "" "" "" "" "" "" "" "" "1443.2" "1298.2" "1415.4" "1265.1" "1244.9" "1435.0" "1249.3" "1406.0" "1846.3" "1494.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3231455898363948540" "False" "High" "IsMasterProtein" "Q15833" "Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2" "0.000" "False" "71.924" "21" "9" "18" "9" "593" "66.4" "6.55" "66.58" "9" "cell-cell signaling;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "6813" "ENSG00000076944" "STXBP2" "B4E175; E7EQD5; hsa:6813; Q15833; Q9BU65" "Platelet degranulation ; Other interleukin signaling" "Splicing factor NOVA regulated synaptic proteins; Insulin signaling" "4" "0" "1.021" "1.004" "0.993" "1.023" "1.031" "0.950" "0.964" "1.018" "1.038" "1638.0" "1671.9" "1644.6" "1626.1" "1675.3" "1688.1" "1555.5" "1579.0" "1666.8" "1700.3" "" "" "" "" "" "" "" "" "" "" "1315.6" "1206.4" "1306.3" "1089.5" "1158.6" "1266.6" "1089.0" "1153.2" "1666.8" "1382.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2943690132932996841" "False" "High" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "0.000" "False" "71.754" "38" "10" "42" "2" "219" "21.9" "11.03" "130.07" "10" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Pathways affected in adenoid cystic carcinoma" "3" "4" "1.068" "1.149" "1.086" "1.076" "1.038" "0.915" "0.878" "0.862" "0.999" "3801.4" "4058.2" "4366.3" "4126.9" "4089.6" "3945.8" "3479.7" "3338.2" "3278.6" "3797.8" "" "" "" "" "" "" "" "" "" "" "3053.2" "2928.3" "3468.3" "2765.0" "2828.4" "2960.4" "2436.3" "2437.9" "3278.6" "3088.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9116145290149312693" "False" "High" "IsMasterProtein" "P42226" "Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1" "0.000" "False" "71.706" "18" "15" "25" "15" "847" "94.1" "6.23" "82.68" "15" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf14596, Pf21354" "6778" "ENSG00000166888" "STAT6" "A8K316; B7ZA27; F5GXI9; hsa:6778; P42226; Q5FBW5; Q71UP4" "Downstream signal transduction; Interleukin-4 and Interleukin-13 signaling; STAT6-mediated induction of chemokines" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Adipogenesis; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; PDGFR-beta pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-19 signaling pathway" "13" "0" "1.003" "1.014" "0.969" "0.980" "0.956" "0.875" "0.978" "0.983" "0.993" "2620.1" "2628.9" "2656.2" "2539.6" "2568.0" "2503.7" "2291.7" "2563.5" "2575.7" "2601.2" "" "" "" "" "" "" "" "" "" "" "2104.4" "1897.0" "2109.9" "1701.5" "1776.1" "1878.5" "1604.6" "1872.1" "2575.7" "2115.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677465183251509063" "False" "High" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=3" "0.000" "False" "71.691" "55" "7" "27" "7" "121" "13.6" "4.82" "92.84" "7" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf19026" "25764" "ENSG00000242028" "HYPK" "C9JKJ0; hsa:25764; O75408; Q8WUW8; Q9NX55; Q9P024" "" "" "0" "0" "1.051" "1.060" "1.138" "1.083" "1.079" "0.981" "1.009" "0.991" "1.047" "2007.2" "2109.0" "2127.6" "2283.6" "2174.2" "2166.6" "1968.7" "2024.4" "1988.7" "2102.2" "" "" "" "" "" "" "" "" "" "" "1612.1" "1521.8" "1690.0" "1530.0" "1503.7" "1625.6" "1378.4" "1478.4" "1988.7" "1709.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000149413272750326" "False" "High" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "0.000" "False" "71.681" "56" "11" "20" "11" "218" "24.5" "5.94" "71.85" "11" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "RAB geranylgeranylation; TBC/RABGAPs" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; Vasopressin-regulated water reabsorption" "5" "0" "0.979" "1.038" "0.942" "0.931" "0.968" "0.890" "0.935" "0.924" "0.917" "2475.9" "2425.1" "2570.8" "2332.1" "2306.2" "2396.0" "2204.5" "2314.2" "2286.6" "2269.2" "" "" "" "" "" "" "" "" "" "" "1988.6" "1749.9" "2042.0" "1562.5" "1595.0" "1797.7" "1543.5" "1690.1" "2286.6" "1845.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1880293335037512275" "False" "High" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "0.000" "False" "71.621" "4" "6" "28" "5" "2078" "205.3" "9.58" "70.76" "6" "other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "1" "1.009" "1.038" "0.975" "0.917" "1.030" "0.949" "0.952" "0.977" "0.934" "1357.8" "1370.5" "1409.4" "1323.8" "1244.7" "1398.1" "1288.2" "1293.1" "1326.8" "1268.4" "" "" "" "" "" "" "" "" "" "" "1090.6" "988.9" "1119.5" "887.0" "860.9" "1049.0" "901.9" "944.3" "1326.8" "1031.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7380698507310522757" "False" "High" "IsMasterProtein" "P41227" "N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1" "0.000" "False" "71.553" "49" "10" "24" "10" "235" "26.4" "5.64" "75.59" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "8260" "ENSG00000102030" "NAA10" "A6NM98; hsa:8260; P41227" "" "" "0" "0" "0.943" "0.965" "0.962" "0.965" "0.925" "0.970" "0.969" "0.927" "0.952" "2027.8" "1912.7" "1956.0" "1950.7" "1957.8" "1876.5" "1967.4" "1964.2" "1879.3" "1930.9" "" "" "" "" "" "" "" "" "" "" "1628.7" "1380.1" "1553.7" "1307.0" "1354.0" "1407.9" "1377.5" "1434.5" "1879.3" "1570.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165870367093882655" "False" "High" "IsMasterProtein" "Q86TI2" "Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3" "0.000" "False" "71.467" "14" "12" "18" "11" "863" "98.2" "6.46" "60.55" "12" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "91039" "ENSG00000142002" "DPP9" "hsa:91039; O75273; O75868; Q1ZZB8; Q6AI37; Q6UAL0; Q6ZMT2; Q6ZNJ5; Q86TI2; Q8N2J7; Q8N3F5; Q8WXD8; Q96NT8; Q9BVR3" "" "Lung fibrosis" "1" "1" "0.977" "0.992" "0.961" "1.036" "0.988" "0.985" "0.989" "0.925" "0.978" "1701.2" "1661.6" "1686.8" "1635.3" "1762.4" "1681.6" "1675.1" "1682.5" "1573.2" "1664.2" "" "" "" "" "" "" "" "" "" "" "1366.4" "1198.9" "1339.9" "1095.7" "1218.9" "1261.6" "1172.8" "1228.7" "1573.2" "1353.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5224017387005900556" "False" "High" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0.000" "False" "71.422" "6" "23" "24" "23" "3859" "437.3" "8.19" "68.36" "23" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Ub-specific processing proteases; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones" "Rett syndrome" "4" "0" "1.047" "1.025" "1.107" "1.007" "1.030" "1.012" "0.986" "0.963" "1.007" "943.8" "987.7" "967.5" "1044.7" "950.3" "972.0" "954.9" "931.0" "909.0" "950.0" "" "" "" "" "" "" "" "" "" "" "758.1" "712.7" "768.5" "700.0" "657.2" "729.3" "668.6" "679.9" "909.0" "772.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7212838211136634633" "False" "High" "IsMasterProtein" "Q9NYY8" "FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1" "0.000" "False" "71.388" "19" "10" "13" "10" "710" "81.4" "8.05" "49.75" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "22868" "ENSG00000118246" "FASTKD2" "hsa:22868; Q9NVX6; Q9NYY8; Q9Y2H7" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "" "1" "0" "0.999" "1.014" "1.016" "0.955" "0.948" "0.906" "1.003" "0.978" "0.992" "659.9" "659.3" "669.1" "670.7" "630.2" "625.6" "598.0" "661.9" "645.6" "654.7" "" "" "" "" "" "" "" "" "" "" "530.0" "475.8" "531.5" "449.4" "435.8" "469.3" "418.7" "483.4" "645.6" "532.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128416838288873001" "False" "High" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "0.000" "False" "71.226" "35" "11" "24" "11" "359" "39.2" "6.65" "79.56" "11" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Orexin receptor pathway" "8" "0" "1.025" "1.006" "1.041" "1.105" "1.040" "1.062" "1.027" "1.083" "1.033" "2425.0" "2484.8" "2438.7" "2523.8" "2678.8" "2521.3" "2575.9" "2491.4" "2627.2" "2506.1" "" "" "" "" "" "" "" "" "" "" "1947.7" "1793.0" "1937.1" "1690.9" "1852.7" "1891.6" "1803.5" "1819.5" "2627.2" "2038.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-327475496585371320" "False" "High" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "0.000" "False" "71.182" "26" "8" "18" "8" "397" "41.3" "6.92" "65.76" "8" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Cholesterol biosynthesis" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "6" "0" "0.990" "0.967" "0.947" "0.965" "0.980" "0.935" "0.902" "0.961" "0.947" "1334.3" "1320.5" "1290.7" "1264.0" "1287.9" "1307.3" "1248.0" "1203.1" "1281.7" "1263.2" "" "" "" "" "" "" "" "" "" "" "1071.7" "952.8" "1025.2" "846.8" "890.7" "980.8" "873.8" "878.6" "1281.7" "1027.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2475503787040523239" "False" "High" "IsMasterProtein" "Q9UM54" "Unconventional myosin-VI OS=Homo sapiens OX=9606 GN=MYO6 PE=1 SV=4" "0.000" "False" "71.171" "10" "10" "13" "10" "1294" "149.6" "8.53" "49.65" "10" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf16521, Pf21521" "4646" "ENSG00000196586" "MYO6" "A6H8V4; E1P540; hsa:4646; Q5TEM5; Q5TEM6; Q5TEM7; Q9BZZ7; Q9UEG2; Q9UM54" "RHOU GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Trafficking of AMPA receptors; Gap junction degradation" "VEGFA-VEGFR2 signaling; Joubert syndrome" "7" "0" "1.080" "1.000" "1.033" "1.040" "1.014" "1.074" "1.034" "1.035" "1.048" "561.6" "606.6" "561.8" "580.2" "584.1" "569.2" "603.0" "580.5" "581.1" "588.4" "" "" "" "" "" "" "" "" "" "" "451.1" "437.7" "446.3" "388.7" "403.9" "427.1" "422.2" "423.9" "581.1" "478.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338451157516248926" "False" "High" "IsMasterProtein" "Q96IZ0" "PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1" "0.000" "False" "71.113" "39" "11" "14" "11" "340" "36.5" "5.41" "50.01" "11" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "5074" "ENSG00000177425" "PAWR" "hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0" "" "" "0" "0" "1.015" "1.037" "0.993" "1.028" "1.012" "1.069" "0.994" "1.008" "1.040" "470.8" "477.8" "488.3" "467.4" "484.2" "476.2" "503.2" "467.9" "474.7" "489.7" "" "" "" "" "" "" "" "" "" "" "378.2" "344.8" "387.8" "313.2" "334.9" "357.3" "352.3" "341.7" "474.7" "398.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4457645785715096452" "False" "High" "IsMasterProtein" "Q9BS26" "Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1" "0.000" "False" "71.047" "36" "13" "17" "12" "406" "46.9" "5.26" "62.31" "13" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "23071" "ENSG00000023318" "ERP44" "hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26" "Neutrophil degranulation" "" "1" "0" "0.949" "0.956" "0.968" "0.972" "0.969" "0.915" "0.932" "0.968" "0.932" "1076.4" "1021.5" "1029.1" "1042.2" "1046.6" "1042.5" "985.2" "1003.1" "1042.1" "1003.1" "" "" "" "" "" "" "" "" "" "" "864.6" "737.1" "817.4" "698.2" "723.8" "782.2" "689.8" "732.6" "1042.1" "815.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7869799461247912985" "False" "High" "IsMasterProtein" "Q96GW9" "Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2" "0.000" "False" "70.998" "23" "11" "14" "11" "593" "66.5" "8.09" "54.86" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf09334, Pf19303" "92935" "ENSG00000247626" "MARS2" "A0AVC3; hsa:92935; Q76E79; Q8IW62; Q8N7N4; Q96GW9" "Mitochondrial tRNA aminoacylation" "Amino acid metabolism" "2" "0" "1.049" "1.011" "1.030" "1.010" "1.042" "0.953" "0.975" "0.980" "1.034" "992.7" "1041.0" "1003.6" "1022.3" "1002.2" "1034.4" "945.9" "967.6" "973.1" "1026.4" "" "" "" "" "" "" "" "" "" "" "797.3" "751.1" "797.2" "684.9" "693.1" "776.1" "662.3" "706.6" "973.1" "834.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8338185896590092974" "False" "High" "IsMasterProtein" "Q9H0B6" "Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1" "0.000" "False" "70.989" "24" "13" "18" "9" "622" "68.9" "7.15" "61.92" "13" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf13424" "64837" "ENSG00000174996" "KLC2" "A8MXL7; B2RDY4; hsa:64837; Q9H0B6; Q9H9C8; Q9HA20" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "6" "1" "1.087" "0.991" "1.018" "0.982" "1.028" "1.019" "1.008" "1.098" "1.066" "1062.4" "1155.0" "1052.4" "1081.4" "1043.4" "1092.4" "1082.8" "1070.7" "1167.0" "1133.0" "" "" "" "" "" "" "" "" "" "" "853.3" "833.4" "836.0" "724.5" "721.6" "819.6" "758.1" "782.0" "1167.0" "921.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-693009755778798309" "False" "High" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=5" "0.000" "False" "70.966" "38" "7" "17" "7" "215" "24.7" "8.51" "66.62" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00957, Pf13774" "9554" "ENSG00000265808" "SEC22B" "A8K1G0; hsa:9554; O75396" "COPI-dependent Golgi-to-ER retrograde traffic; ER-Phagosome pathway; COPII-mediated vesicle transport; Cargo concentration in the ER" "" "4" "0" "0.971" "0.835" "0.939" "0.972" "1.025" "1.001" "1.091" "1.100" "1.007" "2074.3" "2014.2" "1732.8" "1948.4" "2015.5" "2126.7" "2077.3" "2263.1" "2281.5" "2089.3" "" "" "" "" "" "" "" "" "" "" "1666.1" "1453.4" "1376.4" "1305.4" "1393.9" "1595.6" "1454.4" "1652.8" "2281.5" "1699.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981355964815445657" "False" "High" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "0.000" "False" "70.912" "18" "10" "16" "10" "737" "80.9" "5.83" "60.11" "10" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "" "3" "0" "1.014" "0.987" "0.991" "1.018" "0.977" "0.992" "1.012" "1.014" "1.017" "1569.9" "1592.2" "1549.9" "1556.1" "1598.5" "1533.8" "1556.6" "1588.7" "1592.2" "1596.2" "" "" "" "" "" "" "" "" "" "" "1260.9" "1148.9" "1231.1" "1042.6" "1105.5" "1150.7" "1089.9" "1160.2" "1592.2" "1298.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328397515797573102" "False" "High" "IsMasterProtein" "A6NDG6" "Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1" "0.000" "False" "70.900" "40" "9" "17" "9" "321" "34.0" "6.14" "60.78" "9" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13242, Pf13344" "283871" "ENSG00000184207" "PGP" "A6NDG6; hsa:283871" "Glycolysis" "" "1" "0" "0.978" "0.929" "0.975" "0.984" "0.991" "0.960" "0.970" "0.897" "0.968" "961.6" "939.9" "892.9" "937.1" "945.9" "953.0" "922.7" "933.0" "862.1" "930.4" "" "" "" "" "" "" "" "" "" "" "772.3" "678.2" "709.3" "627.9" "654.2" "715.0" "646.0" "681.4" "862.1" "756.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8724268624419382152" "False" "High" "IsMasterProtein" "P50213" "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1" "0.000" "False" "70.854" "32" "12" "24" "12" "366" "39.6" "6.92" "82.96" "12" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3419" "ENSG00000166411" "IDH3A" "D3DW83; hsa:3419; P50213; Q9H3X0" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "5" "0" "0.978" "1.016" "0.963" "0.934" "0.934" "0.905" "0.980" "0.954" "0.940" "2687.2" "2626.8" "2729.4" "2587.7" "2510.3" "2508.8" "2432.8" "2634.7" "2562.3" "2525.8" "" "" "" "" "" "" "" "" "" "" "2158.3" "1895.4" "2168.1" "1733.8" "1736.1" "1882.3" "1703.3" "1924.2" "2562.3" "2054.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3980314117452886183" "False" "High" "IsMasterProtein" "P62979" "Ubiquitin-ribosomal protein eS31 fusion protein OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2" "0.000" "False" "70.843" "46" "8" "145" "1" "156" "18.0" "9.64" "459.54" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01599" "6233" "ENSG00000143947" "RPS27A" "hsa:6233; P02248; P02249; P02250; P14798; P62979; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BQ77; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "Oxidative Stress Induced Senescence; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Cargo recognition for clathrin-mediated endocytosis; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oncogene Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; Regulation of PLK1 Activity at G2/M Transition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); Deactivation of the beta-catenin transactivating complex; Signaling by ALK fusions and activated point mutants; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Interferon alpha/beta signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "Cytoplasmic ribosomal proteins" "203" "6" "1.020" "1.005" "1.002" "1.061" "1.061" "1.034" "1.106" "1.064" "1.045" "8272.8" "8435.3" "8316.3" "8288.9" "8777.8" "8780.9" "8551.5" "9148.3" "8805.7" "8647.5" "" "" "" "" "" "" "" "" "" "" "6644.6" "6086.7" "6605.9" "5553.5" "6070.8" "6588.2" "5987.3" "6681.0" "8805.7" "7032.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8479423548841098522" "False" "High" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "0.000" "False" "70.832" "36" "16" "27" "16" "382" "43.9" "7.46" "75.80" "16" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "1.016" "1.009" "1.005" "0.981" "0.993" "0.995" "1.032" "1.047" "0.996" "2340.5" "2377.4" "2360.9" "2352.6" "2295.1" "2324.0" "2328.0" "2416.5" "2451.6" "2331.0" "" "" "" "" "" "" "" "" "" "" "1879.8" "1715.5" "1875.3" "1576.2" "1587.3" "1743.7" "1629.9" "1764.7" "2451.6" "1895.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1845786618234347704" "False" "High" "IsMasterProtein" "P55263" "Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2" "0.000" "False" "70.827" "40" "10" "15" "10" "362" "40.5" "6.70" "66.17" "10" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "132" "ENSG00000156110" "ADK" "B7Z783; B7Z800; hsa:132; O00741; O00742; P55263; Q16710; Q5JQ10; Q5JQ11; Q9BTN2" "Ribavirin ADME; Purine salvage" "Methionine metabolism leading to sulfur amino acids and related disorders" "3" "0" "1.005" "1.013" "1.006" "1.040" "1.054" "1.004" "1.019" "0.991" "0.998" "1557.7" "1565.6" "1578.0" "1566.6" "1619.8" "1642.1" "1564.2" "1587.2" "1543.4" "1554.1" "" "" "" "" "" "" "" "" "" "" "1251.1" "1129.7" "1253.5" "1049.6" "1120.3" "1232.0" "1095.2" "1159.1" "1543.4" "1263.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097595206598813277" "False" "High" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "0.000" "False" "70.590" "33" "8" "29" "6" "282" "31.3" "9.83" "106.45" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "2" "1.066" "1.010" "1.043" "1.032" "1.015" "0.992" "1.000" "0.962" "1.008" "2389.9" "2548.8" "2414.1" "2491.7" "2465.3" "2426.3" "2371.2" "2389.6" "2299.0" "2409.4" "" "" "" "" "" "" "" "" "" "" "1919.6" "1839.1" "1917.6" "1669.5" "1705.0" "1820.4" "1660.2" "1745.1" "2299.0" "1959.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3039044237151127382" "False" "High" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "0.000" "False" "70.561" "29" "10" "20" "6" "376" "42.6" "6.64" "68.77" "10" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "HDAC6 interactions in the central nervous system" "12" "3" "1.078" "1.061" "1.034" "0.988" "1.051" "1.030" "1.034" "1.058" "1.053" "1654.5" "1783.7" "1755.1" "1710.4" "1634.3" "1739.7" "1704.0" "1711.1" "1750.7" "1742.8" "" "" "" "" "" "" "" "" "" "" "1328.9" "1287.1" "1394.1" "1145.9" "1130.3" "1305.3" "1193.0" "1249.6" "1750.7" "1417.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5102173735616793815" "False" "High" "IsMasterProtein" "Q9BWH6" "RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3" "0.000" "False" "70.521" "17" "16" "19" "16" "1393" "152.7" "6.38" "53.81" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08620, Pf08621" "26015" "ENSG00000103932" "RPAP1" "hsa:26015; Q9BWH6; Q9H9I2; Q9NSQ5; Q9P2E4; Q9UFS7" "" "" "0" "0" "1.004" "0.971" "1.062" "0.963" "1.006" "0.970" "0.988" "1.066" "1.067" "454.3" "456.0" "440.9" "482.4" "437.5" "457.2" "440.8" "448.8" "484.1" "484.8" "" "" "" "" "" "" "" "" "" "" "364.9" "329.0" "350.2" "323.2" "302.6" "343.0" "308.6" "327.7" "484.1" "394.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9192930488046834202" "False" "High" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "0.000" "False" "70.501" "36" "8" "31" "8" "261" "29.5" "7.72" "105.81" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "63" "0" "0.941" "0.954" "0.939" "0.970" "0.977" "0.991" "0.997" "0.931" "0.965" "2474.7" "2329.2" "2361.9" "2324.5" "2400.2" "2418.2" "2453.6" "2467.7" "2304.2" "2387.2" "" "" "" "" "" "" "" "" "" "" "1987.7" "1680.7" "1876.2" "1557.4" "1660.0" "1814.4" "1717.8" "1802.2" "2304.2" "1941.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516801179277526941" "False" "High" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "0.000" "False" "70.489" "38" "12" "39" "12" "228" "26.2" "8.25" "118.87" "12" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "" "Gastric cancer network 2" "1" "0" "0.968" "1.053" "0.940" "0.977" "1.011" "0.941" "1.003" "1.025" "0.961" "3986.7" "3859.2" "4198.6" "3746.1" "3893.4" "4031.4" "3751.7" "3999.7" "4085.5" "3831.7" "" "" "" "" "" "" "" "" "" "" "3202.1" "2784.7" "3335.1" "2509.9" "2692.7" "3024.7" "2626.7" "2921.0" "4085.5" "3116.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1416539979039474058" "False" "High" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "0.000" "False" "70.487" "40" "10" "20" "10" "244" "27.3" "5.15" "73.85" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "Post-chaperonin tubulin folding pathway" "" "1" "0" "0.981" "0.985" "0.958" "0.979" "1.001" "0.935" "0.989" "1.012" "0.931" "1628.6" "1598.2" "1604.6" "1560.5" "1594.3" "1629.6" "1523.1" "1610.9" "1647.6" "1516.9" "" "" "" "" "" "" "" "" "" "" "1308.0" "1153.2" "1274.6" "1045.5" "1102.6" "1222.7" "1066.4" "1176.4" "1647.6" "1233.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766769550040713609" "False" "High" "IsMasterProtein" "Q9UHI6" "Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2" "0.000" "False" "70.377" "17" "12" "16" "12" "824" "92.2" "6.95" "53.22" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11218" "ENSG00000064703" "DDX20" "B4DWV7; hsa:11218; Q96F72; Q9NVM3; Q9UF59; Q9UHI6; Q9UIY0; Q9Y659" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "mRNA processing; Male infertility" "4" "0" "0.980" "0.978" "1.038" "1.052" "1.034" "1.057" "1.102" "1.070" "1.088" "1198.4" "1175.0" "1171.6" "1243.9" "1261.3" "1239.2" "1266.2" "1320.1" "1282.7" "1304.4" "" "" "" "" "" "" "" "" "" "" "962.5" "847.9" "930.6" "833.4" "872.3" "929.8" "886.5" "964.1" "1282.7" "1060.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8973265240341480372" "False" "High" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "0.000" "False" "70.343" "30" "13" "21" "13" "517" "57.4" "6.76" "70.55" "13" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Purine ribonucleoside monophosphate biosynthesis" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "3" "0" "1.005" "0.979" "0.997" "0.961" "0.986" "0.965" "0.915" "0.937" "0.998" "1818.7" "1827.1" "1780.7" "1813.3" "1747.0" "1792.5" "1755.6" "1664.3" "1704.0" "1814.6" "" "" "" "" "" "" "" "" "" "" "1460.7" "1318.4" "1414.5" "1214.9" "1208.2" "1344.9" "1229.2" "1215.4" "1704.0" "1475.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3363379489977265255" "False" "High" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "0.000" "False" "70.329" "55" "7" "44" "7" "154" "15.9" "6.13" "153.95" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation; HDAC6 interactions in the central nervous system" "17" "0" "1.039" "1.005" "1.046" "1.053" "0.993" "1.021" "1.008" "0.987" "0.981" "2088.2" "2169.3" "2098.7" "2184.2" "2199.6" "2074.2" "2131.3" "2104.3" "2060.2" "2048.5" "" "" "" "" "" "" "" "" "" "" "1677.2" "1565.3" "1667.0" "1463.4" "1521.2" "1556.3" "1492.2" "1536.8" "2060.2" "1665.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538184499835993456" "False" "High" "IsMasterProtein" "P43897" "Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2" "0.000" "False" "70.296" "32" "10" "22" "10" "325" "35.4" "8.38" "70.19" "10" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "Pf00889" "10102" "ENSG00000123297" "TSFM" "B4E391; F5H2T7; hsa:10102; P43897; Q561V7; Q8TBC2; Q9UQK0" "Mitochondrial translation elongation" "" "1" "0" "1.004" "1.007" "0.960" "0.973" "0.957" "0.940" "0.989" "0.939" "0.983" "2839.4" "2851.5" "2860.5" "2726.9" "2762.3" "2716.2" "2668.3" "2808.3" "2666.1" "2791.7" "" "" "" "" "" "" "" "" "" "" "2280.5" "2057.5" "2272.2" "1827.0" "1910.4" "2037.9" "1868.2" "2050.9" "2666.1" "2270.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4157182932771800811" "False" "High" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "0.000" "False" "70.293" "43" "11" "25" "11" "248" "27.7" "10.36" "78.88" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "0" "0.962" "1.073" "1.092" "1.271" "1.287" "1.256" "1.263" "1.231" "1.183" "1221.8" "1175.2" "1310.9" "1334.4" "1553.4" "1573.0" "1534.0" "1542.8" "1503.9" "1445.1" "" "" "" "" "" "" "" "" "" "" "981.3" "848.0" "1041.3" "894.1" "1074.4" "1180.2" "1074.0" "1126.7" "1503.9" "1175.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8252267867784187079" "False" "High" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "0.000" "False" "70.279" "29" "15" "20" "14" "633" "68.0" "9.94" "60.55" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "" "6" "1" "1.069" "1.063" "1.055" "0.961" "0.945" "1.019" "1.116" "1.100" "0.995" "2008.0" "2147.5" "2135.1" "2118.2" "1929.6" "1896.7" "2045.3" "2241.2" "2208.1" "1998.8" "" "" "" "" "" "" "" "" "" "" "1612.8" "1549.6" "1696.0" "1419.2" "1334.5" "1423.1" "1432.0" "1636.7" "2208.1" "1625.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642544614061212331" "False" "High" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "0.000" "False" "70.277" "36" "15" "27" "15" "391" "42.3" "10.05" "82.46" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "mRNA Splicing - Major Pathway; RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "8" "0" "0.991" "1.030" "1.074" "1.079" "1.075" "1.129" "1.018" "1.016" "1.048" "2110.3" "2091.2" "2174.4" "2267.0" "2277.3" "2268.9" "2382.8" "2149.1" "2143.7" "2210.8" "" "" "" "" "" "" "" "" "" "" "1694.9" "1509.0" "1727.2" "1518.9" "1575.0" "1702.3" "1668.3" "1569.5" "2143.7" "1797.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6941898924238947203" "False" "High" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "0.000" "False" "70.235" "35" "11" "38" "11" "204" "23.2" "5.11" "111.78" "11" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "Ciliary landscape; Nephrotic syndrome; Vasopressin-regulated water reabsorption" "12" "0" "1.080" "1.100" "1.041" "1.098" "1.073" "1.078" "1.070" "1.151" "1.055" "4279.9" "4620.4" "4709.8" "4456.2" "4699.0" "4593.2" "4613.8" "4581.3" "4927.4" "4517.0" "" "" "" "" "" "" "" "" "" "" "3437.6" "3334.0" "3741.1" "2985.6" "3249.8" "3446.2" "3230.3" "3345.7" "4927.4" "3673.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5487682516941207466" "False" "High" "IsMasterProtein" "P98171" "Rho GTPase-activating protein 4 OS=Homo sapiens OX=9606 GN=ARHGAP4 PE=1 SV=2" "0.000" "False" "70.212" "21" "16" "26" "16" "946" "105.0" "6.34" "71.19" "16" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00611, Pf00620, Pf14604" "393" "ENSG00000089820" "ARHGAP4" "hsa:393; P98171; Q14144; Q86UY3" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "Clock-controlled autophagy in bone metabolism" "4" "0" "1.034" "0.994" "0.991" "1.000" "1.010" "0.927" "0.972" "1.047" "1.025" "858.2" "887.3" "853.1" "850.1" "858.1" "866.4" "795.6" "834.0" "898.8" "880.0" "" "" "" "" "" "" "" "" "" "" "689.3" "640.3" "677.7" "569.6" "593.5" "650.1" "557.0" "609.1" "898.8" "715.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4267649636453152821" "False" "High" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "0.000" "False" "70.180" "65" "13" "78" "13" "149" "17.3" "5.97" "200.61" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Nuclear signaling by ERBB4" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "7" "0" "1.032" "1.025" "1.066" "1.008" "1.038" "1.083" "1.060" "1.029" "1.003" "4476.0" "4620.6" "4585.9" "4772.8" "4511.5" "4647.2" "4849.7" "4743.0" "4604.9" "4489.5" "" "" "" "" "" "" "" "" "" "" "3595.1" "3334.1" "3642.7" "3197.8" "3120.2" "3486.7" "3395.5" "3463.8" "4604.9" "3651.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4567106574901643860" "False" "High" "IsMasterProtein" "O60826" "Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1" "0.000" "False" "70.115" "30" "14" "17" "14" "627" "70.7" "6.74" "59.32" "14" "transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle" "other molecular function" "Pf05667, Pf21674" "28952" "ENSG00000101997" "CCDC22" "A8K7G1; hsa:28952; O60826" "Neddylation" "" "1" "0" "0.955" "1.033" "1.220" "1.149" "0.901" "1.180" "1.106" "1.016" "1.073" "255.6" "244.0" "264.0" "311.9" "293.8" "230.2" "301.5" "282.7" "259.7" "274.4" "" "" "" "" "" "" "" "" "" "" "205.3" "176.1" "209.7" "209.0" "203.2" "172.7" "211.1" "206.5" "259.7" "223.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1385876623079047354" "False" "High" "IsMasterProtein" "Q9UFC0" "Leucine-rich repeat and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRWD1 PE=1 SV=2" "0.000" "False" "70.084" "20" "10" "15" "10" "647" "70.8" "7.21" "55.65" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf00560" "222229" "ENSG00000161036" "LRWD1" "A8K4K2; B2R9G2; hsa:222229; Q8N0T9; Q8WV43; Q96GJ2; Q9UFC0" "" "Male infertility" "1" "0" "1.026" "1.010" "1.024" "1.004" "1.021" "0.974" "0.950" "1.018" "1.017" "1594.1" "1635.3" "1609.6" "1631.8" "1599.7" "1628.3" "1553.0" "1514.3" "1622.0" "1621.9" "" "" "" "" "" "" "" "" "" "" "1280.4" "1180.0" "1278.5" "1093.3" "1106.4" "1221.7" "1087.3" "1105.9" "1622.0" "1319.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758380383998066899" "False" "High" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "0.000" "False" "70.049" "36" "7" "24" "7" "257" "26.9" "11.15" "87.09" "7" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "mRNA Splicing - Major Pathway; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "7" "0" "1.080" "1.106" "1.087" "1.140" "1.122" "1.112" "1.180" "1.099" "1.112" "1390.3" "1501.0" "1538.2" "1511.8" "1585.3" "1559.4" "1545.5" "1640.6" "1527.7" "1546.1" "" "" "" "" "" "" "" "" "" "" "1116.7" "1083.1" "1221.8" "1012.9" "1096.4" "1170.0" "1082.1" "1198.1" "1527.7" "1257.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3113703590403153606" "False" "High" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "0.000" "False" "70.003" "29" "7" "17" "7" "407" "43.4" "8.56" "63.96" "7" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "1.056" "1.006" "1.070" "1.018" "1.033" "1.003" "0.991" "0.957" "1.056" "679.9" "718.0" "684.0" "727.4" "692.4" "702.2" "681.8" "674.1" "650.4" "717.8" "" "" "" "" "" "" "" "" "" "" "546.1" "518.1" "543.3" "487.3" "478.9" "526.8" "477.3" "492.3" "650.4" "583.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "538564902379484332" "False" "High" "IsMasterProtein" "P49815" "Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2" "0.000" "False" "69.952" "10" "13" "16" "13" "1807" "200.5" "7.31" "53.51" "13" "stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf03542, Pf11864" "7249" "ENSG00000103197" "TSC2" "A7E2E2; B4DIL8; B4DIQ7; B4DRN2; B7Z2B8; C9J378; hsa:7249; O75275; P49815; Q4LE71; Q8TAZ1" "Constitutive Signaling by AKT1 E17K in Cancer; TP53 Regulates Metabolic Genes; AKT phosphorylates targets in the cytosol; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; ATM signaling in development and disease ; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; p53 transcriptional gene network; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Monoamine transport" "35" "0" "1.021" "0.943" "0.999" "0.935" "0.975" "0.957" "0.965" "0.965" "1.013" "1034.1" "1055.5" "975.4" "1033.4" "966.6" "1007.8" "990.1" "997.9" "998.0" "1047.9" "" "" "" "" "" "" "" "" "" "" "830.6" "761.6" "774.8" "692.4" "668.5" "756.1" "693.2" "728.7" "998.0" "852.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5664998384620828706" "False" "High" "IsMasterProtein" "Q13895" "Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3" "0.000" "False" "69.946" "34" "12" "14" "12" "437" "49.6" "8.12" "50.88" "12" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05291" "705" "ENSG00000112578" "BYSL" "hsa:705; Q13895; Q6P5W4; Q86W44; Q96IP8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.057" "1.090" "1.116" "1.100" "1.094" "1.134" "1.220" "1.266" "1.093" "1260.2" "1332.2" "1374.0" "1406.7" "1386.7" "1378.6" "1428.7" "1537.6" "1595.4" "1377.0" "" "" "" "" "" "" "" "" "" "" "1012.1" "961.3" "1091.4" "942.5" "959.1" "1034.3" "1000.3" "1122.9" "1595.4" "1119.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3464311242002607672" "False" "High" "IsMasterProtein" "P86790" "Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1" "0.000" "False" "69.857" "29" "13" "19" "13" "482" "55.8" "6.48" "67.15" "13" "transport" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf19031, Pf19032, Pf19033" "221960; 51622" "ENSG00000146574" "CCZ1B" "A2RU45; hsa:221960; hsa:51622; O95766; P86790; Q9UG65; Q9Y359" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.032" "1.000" "1.012" "1.027" "0.964" "1.005" "1.034" "0.963" "0.958" "2163.7" "2233.5" "2163.4" "2189.9" "2222.6" "2086.7" "2175.5" "2237.7" "2082.8" "2071.7" "" "" "" "" "" "" "" "" "" "" "1737.8" "1611.6" "1718.5" "1467.2" "1537.2" "1565.6" "1523.2" "1634.2" "2082.8" "1684.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381305641147496779" "False" "High" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "0.000" "False" "69.734" "54" "11" "32" "11" "217" "24.3" "8.12" "107.25" "11" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "Mitochondrial protein import" "" "1" "0" "1.009" "1.013" "1.007" "0.948" "0.987" "0.983" "0.901" "0.935" "0.967" "4316.4" "4357.4" "4371.5" "4348.3" "4091.7" "4258.1" "4241.5" "3888.8" "4034.0" "4174.4" "" "" "" "" "" "" "" "" "" "" "3466.9" "3144.2" "3472.4" "2913.4" "2829.8" "3194.8" "2969.7" "2840.0" "4034.0" "3394.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524460011519656721" "False" "High" "IsMasterProtein" "P50749" "Ras association domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RASSF2 PE=1 SV=1" "0.000" "False" "69.652" "40" "10" "16" "10" "326" "37.8" "8.84" "49.20" "10" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity" "Pf00788, Pf16517" "9770" "ENSG00000101265" "RASSF2" "A6NIX9; A8K5Z3; hsa:9770; P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5" "" "Pleural mesothelioma" "1" "0" "1.011" "0.982" "1.002" "1.025" "0.955" "0.981" "1.010" "0.980" "0.984" "1221.1" "1234.5" "1199.1" "1222.9" "1251.9" "1166.0" "1197.4" "1233.4" "1196.2" "1201.3" "" "" "" "" "" "" "" "" "" "" "980.8" "890.8" "952.5" "819.4" "865.8" "874.8" "838.4" "900.7" "1196.2" "977.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2707692795518285071" "False" "High" "IsMasterProtein" "Q567U6" "Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2" "0.000" "False" "69.492" "29" "17" "21" "17" "631" "73.2" "8.15" "65.62" "17" "transport" "other cytoplasmic organelle;other cell component" "" "Pf09762, Pf21673" "54520" "ENSG00000125633" "CCDC93" "A8K3V7; hsa:54520; Q4LE78; Q53TJ2; Q567U6; Q8TBX5; Q9H6R5; Q9NV15" "" "" "0" "0" "0.983" "1.005" "1.006" "1.018" "1.003" "1.024" "1.039" "1.027" "1.016" "1060.8" "1042.8" "1065.9" "1066.7" "1080.1" "1063.8" "1085.9" "1102.2" "1089.8" "1078.2" "" "" "" "" "" "" "" "" "" "" "852.0" "752.5" "846.7" "714.7" "747.0" "798.2" "760.3" "804.9" "1089.8" "876.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2599348248423270713" "False" "High" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "0.000" "False" "69.343" "32" "12" "19" "12" "451" "51.1" "6.14" "64.73" "12" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Alstrom syndrome" "8" "0" "1.052" "1.015" "1.080" "1.026" "0.973" "1.012" "1.041" "1.022" "1.040" "952.3" "1001.4" "966.6" "1028.1" "976.9" "926.7" "963.6" "991.7" "972.9" "990.4" "" "" "" "" "" "" "" "" "" "" "764.8" "722.6" "767.8" "688.8" "675.7" "695.3" "674.6" "724.3" "972.9" "805.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2660523182149503333" "False" "High" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "0.000" "False" "69.319" "46" "8" "19" "8" "219" "24.3" "4.94" "78.40" "8" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "Phosphate bond hydrolysis by NUDT proteins" "" "1" "0" "0.956" "0.980" "0.930" "0.904" "1.001" "0.925" "0.896" "0.965" "0.956" "2294.9" "2194.3" "2250.0" "2134.4" "2075.6" "2297.7" "2123.8" "2055.1" "2213.6" "2194.0" "" "" "" "" "" "" "" "" "" "" "1843.3" "1583.4" "1787.2" "1430.1" "1435.5" "1723.9" "1487.0" "1500.9" "2213.6" "1784.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6299048692266605018" "False" "High" "IsMasterProtein" "Q14161" "ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2" "0.000" "False" "69.290" "21" "15" "19" "13" "759" "84.5" "7.23" "69.59" "15" "transport;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf01412, Pf08518, Pf12205, Pf16559" "9815" "ENSG00000139436" "GIT2" "hsa:9815; Q14161; Q86U59; Q96CI2; Q9BV91; Q9Y5V2" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle" "Integrin-mediated cell adhesion" "9" "2" "0.983" "0.955" "0.941" "0.915" "0.983" "0.877" "0.942" "0.969" "0.940" "2699.1" "2653.7" "2578.1" "2539.0" "2468.9" "2653.7" "2367.5" "2543.4" "2615.8" "2538.2" "" "" "" "" "" "" "" "" "" "" "2167.9" "1914.8" "2047.9" "1701.1" "1707.5" "1991.0" "1657.6" "1857.5" "2615.8" "2064.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "567113707807287491" "False" "High" "IsMasterProtein" "Q8NBT2" "Kinetochore protein Spc24 OS=Homo sapiens OX=9606 GN=SPC24 PE=1 SV=3" "0.000" "False" "69.195" "55" "7" "12" "7" "197" "22.4" "4.70" "60.63" "7" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08286" "147841" "ENSG00000161888" "SPC24" "B4DZZ7; C9JGC4; hsa:147841; Q8NBT2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.943" "0.954" "0.994" "1.010" "0.937" "0.985" "0.942" "0.956" "0.950" "878.8" "828.9" "838.7" "873.3" "887.2" "823.1" "865.8" "827.9" "839.8" "834.9" "" "" "" "" "" "" "" "" "" "" "705.9" "598.1" "666.2" "585.1" "613.6" "617.6" "606.2" "604.6" "839.8" "679.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "875070389354990237" "False" "High" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "0.000" "False" "69.069" "29" "8" "16" "8" "331" "36.5" "4.79" "63.77" "8" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis induced DNA fragmentation" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "4" "0" "1.003" "1.003" "0.958" "1.016" "1.046" "1.075" "1.072" "1.071" "1.005" "1453.1" "1457.4" "1456.9" "1392.0" "1475.8" "1520.5" "1561.4" "1557.1" "1556.2" "1459.6" "" "" "" "" "" "" "" "" "" "" "1167.1" "1051.6" "1157.2" "932.6" "1020.7" "1140.8" "1093.2" "1137.2" "1556.2" "1187.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5623462440984321357" "False" "High" "IsMasterProtein" "Q96CW5" "Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2" "0.000" "False" "69.064" "17" "14" "17" "14" "907" "103.5" "8.12" "57.02" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04130, Pf17681" "10426" "ENSG00000126216" "TUBGCP3" "hsa:10426; O43631; O60852; O60853; Q5T8L2; Q7Z4K1; Q96CW5; Q96I79" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "1.011" "0.980" "1.020" "0.962" "0.950" "0.957" "1.017" "1.041" "1.016" "967.0" "977.6" "948.0" "986.2" "930.2" "918.6" "925.9" "983.2" "1006.8" "982.0" "" "" "" "" "" "" "" "" "" "" "776.7" "705.4" "753.0" "660.7" "643.3" "689.2" "648.2" "718.0" "1006.8" "798.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3731678403857668842" "False" "High" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "0.000" "False" "69.048" "43" "8" "17" "8" "282" "31.4" "7.02" "67.49" "8" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Glutathione conjugation" "Phase I biotransformations, non-P450" "2" "0" "0.974" "1.011" "0.935" "0.979" "1.017" "0.925" "0.949" "0.889" "0.986" "1067.0" "1039.0" "1078.8" "997.3" "1044.2" "1085.3" "986.9" "1012.9" "948.2" "1052.1" "" "" "" "" "" "" "" "" "" "" "857.0" "749.7" "857.0" "668.2" "722.1" "814.3" "691.0" "739.7" "948.2" "855.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288043512151873046" "False" "High" "IsMasterProtein" "Q8WU39" "Marginal zone B- and B1-cell-specific protein OS=Homo sapiens OX=9606 GN=MZB1 PE=1 SV=1" "0.000" "False" "69.026" "66" "7" "16" "7" "189" "20.7" "5.57" "67.35" "7" "cell organization and biogenesis;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "Pf11938" "51237" "ENSG00000170476" "MZB1" "D2IYS0; hsa:51237; Q7Z6N2; Q8WU39; Q96RL5; Q9P0T3" "" "" "0" "0" "1.088" "1.058" "1.062" "0.965" "1.061" "0.994" "0.987" "1.039" "0.991" "863.4" "939.1" "913.6" "917.0" "833.1" "916.0" "858.5" "851.8" "897.1" "855.5" "" "" "" "" "" "" "" "" "" "" "693.5" "677.6" "725.7" "614.4" "576.2" "687.2" "601.1" "622.1" "897.1" "695.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7915311945115274700" "False" "High" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "0.000" "False" "69.015" "53" "8" "16" "8" "129" "14.6" "8.88" "64.69" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.072" "1.086" "1.057" "1.025" "1.061" "1.055" "1.107" "1.003" "1.022" "1677.9" "1798.5" "1822.2" "1772.9" "1719.4" "1780.7" "1769.8" "1856.9" "1683.2" "1715.4" "" "" "" "" "" "" "" "" "" "" "1347.7" "1297.7" "1447.5" "1187.8" "1189.1" "1336.0" "1239.1" "1356.1" "1683.2" "1395.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348020526010624498" "False" "High" "IsMasterProtein" "Q13469" "Nuclear factor of activated T-cells, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=NFATC2 PE=1 SV=2" "0.000" "False" "69.012" "18" "14" "16" "14" "925" "100.1" "7.28" "50.90" "14" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4773" "ENSG00000101096" "NFATC2" "B5B2N8; B5B2N9; B5B2P0; B5B2P2; B5B2P3; hsa:4773; Q13468; Q13469; Q5TFW7; Q5TFW8; Q9NPX6; Q9NQH3; Q9UJR2" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)" "Heart development; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Hematopoietic stem cell differentiation; Vitamin D receptor pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; CAMKK2 pathway; 16p11.2 distal deletion syndrome; Calcium mediated T-cell apoptosis involved in inclusion body myositis; T-cell receptor signaling pathway" "21" "0" "1.094" "1.017" "1.098" "1.071" "1.022" "1.076" "1.008" "1.068" "1.036" "1058.4" "1157.4" "1076.6" "1161.9" "1133.7" "1081.3" "1138.9" "1067.3" "1130.6" "1096.1" "" "" "" "" "" "" "" "" "" "" "850.1" "835.1" "855.2" "778.5" "784.1" "811.3" "797.4" "779.5" "1130.6" "891.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "51923672491572090" "False" "High" "IsMasterProtein" "Q4J6C6" "Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1" "0.000" "False" "68.988" "20" "12" "15" "12" "727" "83.9" "6.38" "54.61" "12" "protein metabolism;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00326, Pf02897" "9581" "ENSG00000138078" "PREPL" "A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7" "" "Primary ovarian insufficiency" "1" "0" "0.986" "1.021" "0.946" "0.938" "0.977" "0.973" "1.000" "0.976" "0.967" "1156.7" "1141.1" "1180.5" "1094.2" "1085.5" "1130.5" "1125.7" "1156.2" "1129.5" "1118.7" "" "" "" "" "" "" "" "" "" "" "929.1" "823.4" "937.7" "733.1" "750.7" "848.2" "788.2" "844.3" "1129.5" "909.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8952953409399985954" "False" "High" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "0.000" "False" "68.919" "52" "9" "20" "9" "243" "27.3" "5.08" "65.26" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "1.013" "0.907" "1.005" "0.892" "1.023" "0.932" "0.915" "0.887" "0.929" "1091.4" "1105.4" "989.9" "1097.3" "973.0" "1116.1" "1017.4" "998.1" "968.3" "1013.9" "" "" "" "" "" "" "" "" "" "" "876.6" "797.6" "786.3" "735.2" "672.9" "837.4" "712.3" "728.9" "968.3" "824.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4874402221689570626" "False" "High" "IsMasterProtein" "Q86W56" "Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1" "0.000" "False" "68.869" "14" "11" "16" "11" "976" "111.0" "6.43" "52.65" "11" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05028, Pf20811" "670; 8505" "ENSG00000227345" "PARG" "A5YBK3; B2RC24; B4DIU5; B4DYR4; hsa:8505; I6RUV3; Q6E4P6; Q6E4P7; Q7Z742; Q86W56; Q9Y4W7" "POLB-Dependent Long Patch Base Excision Repair" "10q11.21q11.23 copy number variation syndrome" "2" "0" "1.013" "0.997" "1.023" "1.051" "1.033" "0.998" "1.021" "1.018" "1.051" "1039.6" "1053.6" "1036.7" "1063.9" "1092.7" "1074.2" "1037.1" "1061.8" "1058.5" "1092.7" "" "" "" "" "" "" "" "" "" "" "835.0" "760.2" "823.5" "712.8" "755.7" "806.0" "726.1" "775.5" "1058.5" "888.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8098039391314381890" "False" "High" "IsMasterProtein" "Q92503" "SEC14-like protein 1 OS=Homo sapiens OX=9606 GN=SEC14L1 PE=1 SV=2" "0.000" "False" "68.866" "19" "12" "15" "12" "715" "81.2" "6.43" "57.35" "12" "stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00650, Pf03765, Pf04707" "6397" "ENSG00000129657" "SEC14L1" "A8K4E8; B4DDI5; D5G3K1; hsa:6397; Q92503; Q99780" "" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "2" "0" "1.045" "1.015" "0.987" "0.953" "0.998" "0.946" "1.022" "0.996" "1.001" "1217.4" "1272.1" "1235.8" "1201.7" "1160.5" "1215.5" "1151.9" "1243.8" "1212.1" "1218.7" "" "" "" "" "" "" "" "" "" "" "977.8" "917.9" "981.6" "805.1" "802.6" "912.0" "806.5" "908.4" "1212.1" "991.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1150602487247342071" "False" "High" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "0.000" "False" "68.802" "46" "11" "16" "11" "307" "34.5" "6.70" "52.09" "11" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "22q11.2 copy number variation syndrome" "5" "0" "1.056" "1.051" "1.056" "1.024" "1.016" "1.050" "1.106" "1.096" "1.080" "952.6" "1006.3" "1000.8" "1005.9" "975.5" "968.3" "1000.3" "1053.4" "1044.3" "1028.8" "" "" "" "" "" "" "" "" "" "" "765.1" "726.1" "795.0" "674.0" "674.7" "726.5" "700.3" "769.3" "1044.3" "836.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7172207260123364247" "False" "High" "IsMasterProtein" "P11172" "Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1" "0.000" "False" "68.793" "34" "16" "22" "16" "480" "52.2" "7.24" "75.21" "16" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00156, Pf00215" "7372" "ENSG00000114491" "UMPS" "B5LY68; B5LY72; hsa:7372; O00758; O00759; O00760; P11172; Q16862; Q9H3Q2; Q9UG49" "Pyrimidine biosynthesis" "Fluoropyrimidine activity; Pyrimidine metabolism" "3" "0" "0.983" "1.033" "1.001" "0.998" "0.995" "0.946" "0.930" "1.001" "1.008" "2127.1" "2090.3" "2198.1" "2129.9" "2123.7" "2117.2" "2012.0" "1977.1" "2129.4" "2144.4" "" "" "" "" "" "" "" "" "" "" "1708.4" "1508.3" "1746.0" "1427.0" "1468.8" "1588.5" "1408.7" "1443.9" "2129.4" "1743.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749791296604860145" "False" "High" "IsMasterProtein" "Q9BTE6" "Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1 PE=1 SV=2" "0.000" "False" "68.779" "35" "11" "21" "11" "412" "45.5" "6.42" "82.86" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07973" "100885850; 80755" "ENSG00000108825; ENSG00000266967" "AARSD1" "B4DI73; hsa:100885850; hsa:80755; Q9BTE6" "" "" "0" "0" "0.966" "0.971" "1.063" "1.046" "0.975" "1.042" "0.975" "0.994" "0.982" "1539.4" "1486.9" "1494.7" "1636.4" "1610.1" "1500.3" "1603.5" "1501.7" "1529.6" "1511.0" "" "" "" "" "" "" "" "" "" "" "1236.4" "1072.9" "1187.3" "1096.4" "1113.6" "1125.7" "1122.7" "1096.7" "1529.6" "1228.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1188306556528865133" "False" "High" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "0.000" "False" "68.774" "32" "8" "27" "8" "268" "30.0" "5.14" "101.69" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Microtubule cytoskeleton regulation; HDAC6 interactions in the central nervous system" "16" "0" "0.947" "0.938" "0.903" "0.896" "0.906" "0.875" "0.904" "0.946" "0.915" "2877.9" "2725.9" "2699.6" "2598.6" "2580.0" "2606.3" "2517.6" "2601.4" "2722.3" "2634.7" "" "" "" "" "" "" "" "" "" "" "2311.5" "1966.9" "2144.4" "1741.1" "1784.4" "1955.5" "1762.7" "1899.8" "2722.3" "2142.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8995832376771225777" "False" "High" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "0.000" "False" "68.727" "27" "9" "16" "9" "358" "40.5" "6.18" "61.44" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response" "2" "0" "0.981" "0.967" "0.947" "0.955" "1.025" "0.987" "1.082" "1.023" "1.005" "1710.0" "1676.8" "1653.0" "1619.0" "1633.7" "1753.0" "1687.2" "1849.5" "1749.8" "1719.0" "" "" "" "" "" "" "" "" "" "" "1373.4" "1209.9" "1313.0" "1084.8" "1129.9" "1315.2" "1181.3" "1350.7" "1749.8" "1397.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5955155913055998566" "False" "High" "IsMasterProtein" "P28062" "Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3" "0.000" "False" "68.648" "47" "10" "15" "10" "276" "30.3" "7.43" "56.87" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5696" "ENSG00000204264; ENSG00000206298; ENSG00000226201; ENSG00000230034; ENSG00000230669; ENSG00000231631; ENSG00000235715; ENSG00000236443" "PSMB8" "B0UZC0; hsa:5696; P28062; Q29824; Q5JNW6; Q5QNR8; Q96J48" "Regulation of RAS by GAPs; Orc1 removal from chromatin; Assembly of the pre-replicative complex; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Interferon alpha/beta signaling" "Proteasome degradation; Immune response to tuberculosis" "62" "0" "0.932" "0.940" "0.960" "1.037" "0.998" "0.982" "1.011" "0.918" "0.967" "889.2" "829.0" "836.1" "854.0" "922.4" "887.0" "872.8" "898.9" "816.6" "860.1" "" "" "" "" "" "" "" "" "" "" "714.2" "598.2" "664.1" "572.2" "637.9" "665.5" "611.1" "656.5" "816.6" "699.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604354164667528726" "False" "High" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "0.000" "False" "68.636" "28" "16" "19" "16" "683" "78.5" "6.87" "62.91" "16" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Signaling by CSF1 (M-CSF) in myeloid cells" "" "4" "0" "1.003" "1.062" "1.072" "1.014" "1.028" "1.016" "0.969" "1.069" "1.040" "1331.8" "1335.2" "1414.3" "1427.9" "1350.7" "1368.9" "1352.7" "1290.8" "1423.7" "1385.0" "" "" "" "" "" "" "" "" "" "" "1069.7" "963.5" "1123.4" "956.7" "934.2" "1027.0" "947.1" "942.7" "1423.7" "1126.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851558283081104520" "False" "High" "IsMasterProtein" "Q14145" "Kelch-like ECH-associated protein 1 OS=Homo sapiens OX=9606 GN=KEAP1 PE=1 SV=2" "0.000" "False" "68.590" "22" "12" "16" "12" "624" "69.6" "6.44" "57.32" "12" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "9817" "ENSG00000079999" "KEAP1" "B3KPD5; hsa:9817; Q14145; Q6LEP0; Q8WTX1; Q9BPY9" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Nuclear events mediated by NFE2L2" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Hereditary leiomyomatosis and renal cell carcinoma pathway; NRF2-ARE regulation; Head and neck squamous cell carcinoma; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "16" "0" "0.987" "1.010" "0.983" "1.083" "1.025" "1.054" "1.098" "0.994" "0.991" "1002.9" "989.9" "1012.7" "985.7" "1085.8" "1028.1" "1057.2" "1101.4" "996.6" "993.9" "" "" "" "" "" "" "" "" "" "" "805.5" "714.3" "804.4" "660.4" "750.9" "771.4" "740.2" "804.4" "996.6" "808.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193290723324093172" "False" "High" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "0.000" "False" "68.587" "42" "9" "30" "9" "252" "26.5" "9.36" "91.32" "9" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "" "Pyrimidine metabolism" "1" "0" "0.971" "0.974" "0.946" "1.042" "0.972" "1.045" "1.070" "1.111" "1.018" "2053.7" "1993.7" "1999.7" "1943.2" "2139.9" "1995.8" "2145.1" "2198.3" "2280.9" "2090.6" "" "" "" "" "" "" "" "" "" "" "1649.5" "1438.6" "1588.5" "1302.0" "1480.0" "1497.4" "1501.9" "1605.4" "2280.9" "1700.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625236690753071245" "False" "High" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "0.000" "False" "68.535" "47" "10" "21" "10" "227" "24.6" "7.21" "63.18" "10" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Protein repair" "Primary ovarian insufficiency" "2" "0" "0.962" "0.995" "0.994" "0.974" "0.986" "0.913" "0.916" "1.017" "0.940" "886.9" "853.6" "882.3" "881.7" "864.3" "874.1" "810.0" "812.0" "902.2" "833.9" "" "" "" "" "" "" "" "" "" "" "712.4" "616.0" "700.8" "590.7" "597.8" "655.9" "567.1" "593.0" "902.2" "678.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8330278091767700695" "False" "High" "IsMasterProtein" "Q6PCB5" "Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2" "0.000" "False" "68.456" "17" "13" "16" "13" "846" "94.8" "8.78" "62.62" "13" "" "nucleus" "other molecular function" "" "222194" "ENSG00000187257" "RSBN1L" "C9K0P1; hsa:222194; Q6PCB5; Q6ZS58; Q6ZVI9; Q86X48" "" "" "0" "0" "1.002" "1.012" "1.049" "1.020" "0.999" "1.039" "1.081" "1.036" "1.041" "1676.0" "1679.5" "1696.6" "1757.6" "1709.9" "1674.7" "1741.9" "1812.0" "1737.1" "1745.1" "" "" "" "" "" "" "" "" "" "" "1346.1" "1211.9" "1347.7" "1177.6" "1182.6" "1256.5" "1219.6" "1323.3" "1737.1" "1419.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-199396300438152648" "False" "High" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "0.000" "False" "68.389" "40" "12" "34" "12" "255" "28.4" "5.33" "99.35" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; Regulation of RUNX3 expression and activity; ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC); Somitogenesis" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.922" "1.000" "0.845" "0.985" "1.010" "0.920" "0.964" "0.974" "0.951" "4135.2" "3812.0" "4135.8" "3496.2" "4074.8" "4176.0" "3805.0" "3985.1" "4025.8" "3934.1" "" "" "" "" "" "" "" "" "" "" "3321.4" "2750.6" "3285.2" "2342.4" "2818.2" "3133.2" "2664.1" "2910.3" "4025.8" "3199.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3946682035619075212" "False" "High" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "0.000" "False" "68.353" "34" "7" "18" "7" "224" "25.2" "9.28" "66.89" "7" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "1.015" "1.079" "0.999" "0.976" "1.021" "1.033" "1.042" "1.004" "1.004" "2463.0" "2499.8" "2656.7" "2460.8" "2404.3" "2515.5" "2543.8" "2566.5" "2473.7" "2472.0" "" "" "" "" "" "" "" "" "" "" "1978.2" "1803.8" "2110.3" "1648.8" "1662.8" "1887.3" "1781.0" "1874.3" "2473.7" "2010.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220187434067665020" "False" "High" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "0.000" "False" "68.283" "23" "15" "22" "15" "736" "82.8" "7.31" "65.29" "15" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "1.047" "1.072" "1.033" "1.109" "1.042" "1.072" "1.088" "1.150" "1.072" "969.5" "1015.2" "1039.3" "1001.6" "1075.4" "1010.3" "1039.0" "1054.6" "1115.2" "1039.5" "" "" "" "" "" "" "" "" "" "" "778.7" "732.5" "825.6" "671.1" "743.8" "758.0" "727.5" "770.2" "1115.2" "845.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6388610480367959150" "False" "High" "IsMasterProtein" "O15446" "DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=POLR1G PE=1 SV=1" "0.000" "False" "68.252" "30" "9" "11" "9" "510" "55.0" "8.51" "52.48" "9" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf08208" "10849" "ENSG00000117877" "POLR1G" "hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "2q13 copy number variation syndrome" "6" "0" "1.070" "1.057" "1.120" "1.006" "1.067" "1.006" "0.995" "0.948" "1.042" "976.4" "1045.1" "1032.2" "1093.4" "982.6" "1042.2" "981.8" "971.5" "925.9" "1017.7" "" "" "" "" "" "" "" "" "" "" "784.2" "754.1" "819.9" "732.6" "679.6" "781.9" "687.4" "709.5" "925.9" "827.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7294352330531963904" "False" "High" "IsMasterProtein" "Q99439" "Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4" "0.000" "False" "68.224" "31" "8" "26" "8" "309" "33.7" "7.33" "81.40" "8" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00402" "1265" "ENSG00000064666" "CNN2" "A5D8U8; A6NFI4; D6W5X9; hsa:1265; Q92578; Q99439" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Myometrial relaxation and contraction pathways; Burn wound healing" "4" "0" "1.011" "1.044" "0.991" "1.004" "0.984" "1.059" "1.068" "1.000" "0.990" "2558.8" "2587.5" "2671.2" "2536.0" "2568.5" "2518.0" "2710.0" "2733.4" "2559.2" "2532.0" "" "" "" "" "" "" "" "" "" "" "2055.2" "1867.1" "2121.8" "1699.1" "1776.4" "1889.2" "1897.4" "1996.2" "2559.2" "2059.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381164833794741619" "False" "High" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "0.000" "False" "68.162" "23" "15" "23" "15" "639" "71.4" "6.40" "66.41" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf07653, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Nephrin family interactions" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "5" "0" "0.992" "1.006" "1.037" "1.007" "0.992" "1.001" "1.026" "1.017" "1.007" "2069.4" "2053.3" "2082.7" "2147.0" "2084.4" "2053.4" "2071.7" "2123.2" "2103.7" "2083.8" "" "" "" "" "" "" "" "" "" "" "1662.1" "1481.6" "1654.3" "1438.5" "1441.6" "1540.6" "1450.5" "1550.5" "2103.7" "1694.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4344816618369671433" "False" "High" "IsMasterProtein" "Q16537" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1" "0.000" "False" "68.101" "25" "11" "17" "9" "467" "54.7" "6.95" "66.20" "11" "signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5529" "ENSG00000154001" "PPP2R5E" "A4FU37; B7ZAW5; B7ZKK8; B7ZKK9; hsa:5529; J3KQN6; Q16537; Q52LW4" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "28" "1" "0.991" "0.964" "0.999" "0.928" "0.948" "0.934" "0.912" "0.974" "0.989" "1176.7" "1166.3" "1134.5" "1175.0" "1091.5" "1115.9" "1099.6" "1073.0" "1145.6" "1163.2" "" "" "" "" "" "" "" "" "" "" "945.1" "841.6" "901.2" "787.3" "754.9" "837.3" "769.9" "783.6" "1145.6" "946.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100210059596347713" "False" "High" "IsMasterProtein" "P04899" "Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3" "0.000" "False" "68.097" "27" "6" "12" "5" "355" "40.4" "5.54" "47.48" "6" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2771" "ENSG00000114353" "GNAI2" "B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion" "Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "22" "0" "1.000" "0.926" "1.001" "1.048" "1.028" "1.095" "1.011" "1.006" "1.094" "474.6" "474.4" "439.4" "475.3" "497.2" "487.9" "519.9" "479.6" "477.4" "519.5" "" "" "" "" "" "" "" "" "" "" "381.2" "342.3" "349.1" "318.4" "343.9" "366.1" "364.0" "350.3" "477.4" "422.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403142608945012148" "False" "High" "IsMasterProtein" "Q8IX01" "SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2" "0.000" "False" "68.086" "14" "14" "14" "14" "1082" "120.1" "7.28" "49.17" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "10147" "ENSG00000064607" "SUGP2" "C9JI71; hsa:10147; O15071; O60369; Q5JPH7; Q8IX01; Q8WUF7" "" "mRNA processing" "1" "0" "1.031" "1.096" "1.004" "0.990" "1.054" "1.009" "1.135" "1.058" "1.113" "1000.4" "1031.4" "1096.4" "1004.0" "990.8" "1054.0" "1009.6" "1135.3" "1058.4" "1113.4" "" "" "" "" "" "" "" "" "" "" "803.5" "744.2" "870.9" "672.7" "685.2" "790.8" "706.8" "829.1" "1058.4" "905.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7018160903413407228" "False" "High" "IsMasterProtein" "Q9BW85" "Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1" "0.000" "False" "68.079" "34" "11" "17" "11" "323" "37.1" "5.92" "60.97" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf04502" "55702" "ENSG00000105248" "YJU2" "hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16" "mRNA Splicing - Major Pathway" "" "1" "0" "1.023" "1.022" "1.081" "1.019" "0.998" "1.034" "1.020" "1.017" "1.042" "1626.0" "1663.7" "1662.0" "1757.2" "1656.1" "1622.9" "1680.9" "1657.8" "1654.2" "1694.3" "" "" "" "" "" "" "" "" "" "" "1306.0" "1200.5" "1320.1" "1177.3" "1145.4" "1217.7" "1176.9" "1210.7" "1654.2" "1377.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5379927886480691395" "False" "High" "IsMasterProtein" "O95456" "Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1" "0.000" "False" "68.054" "32" "9" "19" "9" "288" "32.8" "7.17" "65.51" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf16094" "8624" "ENSG00000183527" "PSMG1" "B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713" "" "" "0" "0" "1.002" "1.020" "1.059" "1.058" "0.980" "1.044" "0.997" "0.951" "0.994" "1496.0" "1499.1" "1526.3" "1584.8" "1583.1" "1466.8" "1562.2" "1491.7" "1422.6" "1487.7" "" "" "" "" "" "" "" "" "" "" "1201.6" "1081.7" "1212.4" "1061.8" "1094.9" "1100.5" "1093.7" "1089.4" "1422.6" "1209.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531789863272175239" "False" "High" "IsMasterProtein" "Q9BU89" "Deoxyhypusine hydroxylase OS=Homo sapiens OX=9606 GN=DOHH PE=1 SV=1" "0.000" "False" "68.017" "35" "6" "15" "6" "302" "32.9" "4.83" "58.45" "6" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf13646" "83475" "ENSG00000129932" "DOHH" "O75265; Q9BU89" "Hypusine synthesis from eIF5A-lysine" "" "1" "0" "0.966" "1.046" "1.121" "1.026" "0.988" "1.135" "1.029" "1.031" "1.046" "487.4" "470.8" "509.8" "546.3" "500.2" "481.7" "553.4" "501.6" "502.4" "509.8" "" "" "" "" "" "" "" "" "" "" "391.5" "339.7" "405.0" "366.0" "345.9" "361.4" "387.5" "366.3" "502.4" "414.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3625950205882740020" "False" "High" "IsMasterProtein" "Q9NWQ8" "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 OS=Homo sapiens OX=9606 GN=PAG1 PE=1 SV=2" "0.000" "False" "67.974" "27" "8" "11" "8" "432" "47.0" "4.65" "49.27" "8" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15347" "55824" "ENSG00000076641" "PAG1" "A8K1A3; hsa:55824; Q2M1Z9; Q5BKU4; Q9NWQ8; Q9NYK0" "Phosphorylation of CD3 and TCR zeta chains; GAB1 signalosome" "" "2" "0" "1.022" "0.931" "1.052" "1.038" "1.083" "1.139" "1.122" "1.153" "1.040" "1043.9" "1066.8" "972.1" "1098.5" "1083.7" "1130.9" "1189.2" "1170.9" "1203.2" "1085.8" "" "" "" "" "" "" "" "" "" "" "838.4" "769.8" "772.2" "736.0" "749.5" "848.5" "832.6" "855.1" "1203.2" "883.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5779519367271372583" "False" "High" "IsMasterProtein" "Q15645" "Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2" "0.000" "False" "67.961" "29" "12" "17" "12" "432" "48.5" "6.09" "63.62" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004" "9319" "ENSG00000071539" "TRIP13" "C9K0T3; D3DTC0; hsa:9319; O15324; Q15645" "" "Male infertility" "1" "0" "1.055" "1.030" "1.031" "1.007" "1.020" "0.994" "1.097" "1.044" "1.019" "1624.2" "1714.1" "1672.3" "1674.3" "1635.3" "1657.2" "1614.2" "1781.1" "1696.2" "1655.7" "" "" "" "" "" "" "" "" "" "" "1304.6" "1236.8" "1328.4" "1121.8" "1131.0" "1243.4" "1130.2" "1300.8" "1696.2" "1346.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6575553270224251994" "False" "High" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "0.000" "False" "67.942" "36" "15" "35" "14" "431" "49.2" "5.58" "99.05" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "4" "1" "0.992" "1.007" "0.993" "0.993" "1.001" "0.984" "0.970" "0.995" "1.004" "3436.8" "3410.0" "3460.9" "3413.1" "3414.5" "3440.2" "3381.9" "3335.2" "3420.4" "3449.2" "" "" "" "" "" "" "" "" "" "" "2760.4" "2460.6" "2749.1" "2286.8" "2361.5" "2581.1" "2367.8" "2435.7" "3420.4" "2805.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9134922039646345365" "False" "High" "IsMasterProtein" "Q8NBF2" "NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1" "0.000" "False" "67.911" "17" "11" "17" "11" "726" "79.4" "5.55" "56.93" "11" "" "non-structural extracellular;cytosol;other cell component" "" "Pf01436, Pf13905" "374354" "ENSG00000196865" "NHLRC2" "hsa:374354; Q8N1H1; Q8N5A6; Q8NBF2" "Platelet degranulation" "" "1" "0" "1.046" "0.981" "1.054" "1.083" "1.014" "1.021" "0.992" "0.997" "1.068" "1344.9" "1407.0" "1318.7" "1418.1" "1456.0" "1364.0" "1372.6" "1333.7" "1340.2" "1435.9" "" "" "" "" "" "" "" "" "" "" "1080.2" "1015.3" "1047.5" "950.1" "1007.0" "1023.4" "961.0" "974.0" "1340.2" "1167.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851327045355939363" "False" "High" "IsMasterProtein" "P16401" "Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3" "0.000" "False" "67.822" "35" "10" "34" "6" "226" "22.6" "10.92" "98.48" "10" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3009" "ENSG00000184357" "H1-5" "hsa:3009; P16401; Q14529; Q3MJ42" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "3" "1.039" "1.125" "1.057" "1.076" "1.054" "1.006" "0.991" "1.008" "1.042" "2936.7" "3051.8" "3303.7" "3105.0" "3160.7" "3093.8" "2954.9" "2911.7" "2960.2" "3059.1" "" "" "" "" "" "" "" "" "" "" "2358.7" "2202.1" "2624.2" "2080.4" "2186.0" "2321.2" "2068.9" "2126.4" "2960.2" "2487.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079074271338885879" "False" "High" "IsMasterProtein" "P16403" "Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2" "0.000" "False" "67.798" "36" "9" "39" "1" "213" "21.4" "10.93" "121.51" "9" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3006" "ENSG00000187837" "H1-2" "A8K4I2; hsa:3006; P16403" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "0" "1.058" "1.115" "1.154" "1.101" "1.367" "0.917" "0.606" "0.823" "0.961" "126.6" "134.0" "141.2" "146.1" "139.3" "173.0" "116.2" "76.8" "104.2" "121.6" "" "" "" "" "" "" "" "" "" "" "101.7" "96.7" "112.2" "97.9" "96.4" "129.8" "81.3" "56.1" "104.2" "98.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636638520442762569" "False" "High" "IsMasterProtein" "P54725" "UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1" "0.000" "False" "67.739" "31" "9" "17" "6" "363" "39.6" "4.58" "59.61" "9" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5886" "ENSG00000179262" "RAD23A" "hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "6" "0" "1.218" "1.098" "1.157" "1.084" "1.152" "1.147" "1.131" "1.196" "1.092" "430.3" "523.9" "472.5" "497.7" "466.4" "495.7" "493.5" "486.7" "514.7" "470.0" "" "" "" "" "" "" "" "" "" "" "345.6" "378.1" "375.3" "333.5" "322.5" "371.9" "345.5" "355.4" "514.7" "382.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9117117300834082613" "False" "High" "IsMasterProtein" "Q9H5N1" "Rab GTPase-binding effector protein 2 OS=Homo sapiens OX=9606 GN=RABEP2 PE=1 SV=2" "0.000" "False" "67.690" "23" "13" "15" "13" "569" "63.5" "4.78" "52.25" "13" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf03528, Pf09311" "79874" "ENSG00000177548" "RABEP2" "hsa:79874; Q9H5N1" "" "Ciliary landscape; 16p11.2 distal deletion syndrome" "2" "0" "0.993" "0.946" "1.006" "1.002" "1.007" "0.967" "0.974" "1.049" "1.022" "939.1" "932.5" "888.5" "944.9" "940.6" "945.4" "908.6" "914.9" "985.5" "959.8" "" "" "" "" "" "" "" "" "" "" "754.3" "672.8" "705.8" "633.1" "650.5" "709.3" "636.1" "668.2" "985.5" "780.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7662049170687489427" "False" "High" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "0.000" "False" "67.656" "44" "16" "25" "14" "341" "39.8" "6.89" "73.55" "16" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "6" "2" "0.958" "0.996" "0.890" "0.903" "0.960" "0.873" "0.881" "0.878" "0.912" "2470.7" "2367.4" "2459.8" "2199.1" "2231.5" "2371.2" "2156.1" "2177.1" "2170.1" "2254.5" "" "" "" "" "" "" "" "" "" "" "1984.5" "1708.2" "1953.9" "1473.4" "1543.3" "1779.1" "1509.6" "1590.0" "2170.1" "1833.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7162742285351111146" "False" "High" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "0.000" "False" "67.606" "22" "13" "19" "8" "715" "80.7" "9.26" "59.57" "13" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "Effect of progerin on genes involved in progeria; TAR syndrome" "8" "0" "1.003" "1.096" "0.995" "0.917" "0.972" "1.024" "1.123" "1.032" "1.057" "645.1" "646.8" "707.0" "642.2" "591.4" "627.1" "660.6" "724.5" "665.6" "681.5" "" "" "" "" "" "" "" "" "" "" "518.1" "466.7" "561.6" "430.2" "409.0" "470.5" "462.5" "529.1" "665.6" "554.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208220757799786637" "False" "High" "IsMasterProtein" "Q9BTC8" "Metastasis-associated protein MTA3 OS=Homo sapiens OX=9606 GN=MTA3 PE=1 SV=2" "0.000" "False" "67.605" "28" "14" "27" "8" "594" "67.5" "8.57" "69.37" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "57504" "ENSG00000057935" "MTA3" "hsa:57504; Q9BTC8; Q9NSP2; Q9ULF4" "Potential therapeutics for SARS; HDACs deacetylate histones; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Pre-implantation embryo; Effect of progerin on genes involved in progeria" "7" "2" "1.029" "1.006" "0.944" "0.872" "0.909" "0.915" "1.067" "0.963" "0.947" "877.7" "903.4" "882.8" "828.5" "765.1" "797.6" "802.8" "936.7" "845.0" "831.0" "" "" "" "" "" "" "" "" "" "" "705.0" "651.9" "701.3" "555.1" "529.2" "598.4" "562.1" "684.1" "845.0" "675.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488452650529328010" "False" "High" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=2" "0.000" "False" "67.583" "16" "12" "22" "12" "832" "94.3" "6.70" "69.87" "12" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04100, Pf16854" "55275" "ENSG00000141252; ENSG00000283883" "VPS53" "A8K2S8; B3FH42; hsa:55275; Q5VIR6; Q8WYW3; Q9BRR2; Q9BY02; Q9NV25" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.070" "1.029" "1.014" "1.000" "0.979" "1.021" "0.988" "0.966" "1.034" "880.9" "942.5" "906.8" "893.4" "880.5" "862.4" "899.1" "870.7" "850.7" "910.9" "" "" "" "" "" "" "" "" "" "" "707.5" "680.1" "720.3" "598.6" "609.0" "647.1" "629.5" "635.9" "850.7" "740.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "217416082876923675" "False" "High" "IsMasterProtein" "O75410" "Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2" "0.000" "False" "67.497" "20" "13" "14" "13" "805" "87.7" "4.88" "51.19" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05010" "6867" "ENSG00000147526" "TACC1" "B2RBD9; B4E302; D3DSX6; hsa:6867; O75410; Q6Y687; Q86YG7; Q8IUJ2; Q8IUJ3; Q8IUJ4; Q8IZG2; Q8NEY7; Q9UPP9" "" "" "0" "0" "1.084" "0.975" "1.096" "1.047" "1.060" "1.125" "1.102" "1.105" "1.089" "1209.8" "1311.8" "1179.9" "1325.8" "1267.0" "1282.5" "1361.5" "1332.9" "1337.0" "1317.5" "" "" "" "" "" "" "" "" "" "" "971.7" "946.6" "937.3" "888.3" "876.3" "962.2" "953.3" "973.4" "1337.0" "1071.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5461850800476976864" "False" "High" "IsMasterProtein" "Q9UBB5" "Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1" "0.000" "False" "67.473" "31" "10" "17" "9" "411" "43.2" "10.04" "56.34" "10" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "8932" "ENSG00000134046" "MBD2" "hsa:8932; O95242; Q9UBB5; Q9UIS8" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening" "Effect of progerin on genes involved in progeria" "3" "0" "1.089" "1.111" "1.009" "0.916" "0.979" "0.968" "1.172" "1.045" "1.031" "825.6" "898.8" "917.6" "832.7" "756.3" "808.1" "799.0" "967.6" "862.9" "851.4" "" "" "" "" "" "" "" "" "" "" "663.1" "648.5" "728.9" "557.9" "523.1" "606.3" "559.4" "706.7" "862.9" "692.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765890645847651977" "False" "High" "IsMasterProtein" "Q14790" "Caspase-8 OS=Homo sapiens OX=9606 GN=CASP8 PE=1 SV=1" "0.000" "False" "67.428" "27" "9" "13" "9" "479" "55.4" "5.10" "48.92" "9" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00656, Pf01335" "841" "ENSG00000064012" "CASP8" "hsa:841; O14676; Q14790; Q14791; Q14792; Q14793; Q14794; Q14795; Q14796; Q15780; Q15806; Q53TT5; Q8TDI1; Q8TDI2; Q8TDI3; Q8TDI4; Q8TDI5; Q96T22; Q9C0K4; Q9UQ81" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Regulation of NF-kappa B signaling; TLR3-mediated TICAM1-dependent programmed cell death; Caspase-mediated cleavage of cytoskeletal proteins; TNFR1-induced proapoptotic signaling; CLEC7A/inflammasome pathway; Microbial modulation of RIPK1-mediated regulated necrosis; Activation, myristolyation of BID and translocation to mitochondria; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; 16p11.2 proximal deletion syndrome; Complement system in neuronal development and plasticity; CCL18 signaling pathway; Alzheimer's disease; DNA damage response; Toll-like receptor signaling pathway" "54" "0" "1.012" "0.957" "0.943" "0.973" "0.956" "0.947" "0.933" "0.948" "0.917" "1010.4" "1022.4" "966.7" "953.2" "983.2" "965.4" "957.2" "942.4" "958.3" "926.1" "" "" "" "" "" "" "" "" "" "" "811.5" "737.7" "767.9" "638.6" "680.0" "724.4" "670.2" "688.2" "958.3" "753.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3000409602916512702" "False" "High" "IsMasterProtein" "O15357" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2" "0.000" "False" "67.366" "14" "16" "17" "14" "1258" "138.5" "6.54" "53.21" "16" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00017, Pf00536" "3636" "ENSG00000165458" "INPPL1" "B2RTX5; hsa:3636; O15357; Q13577; Q13578" "Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells" "EGF/EGFR signaling pathway; Insulin signaling" "6" "0" "1.051" "0.981" "1.119" "1.068" "0.974" "1.033" "1.052" "1.056" "1.082" "878.0" "923.2" "861.3" "982.2" "937.4" "855.6" "906.9" "923.5" "927.3" "949.6" "" "" "" "" "" "" "" "" "" "" "705.2" "666.1" "684.1" "658.1" "648.3" "641.9" "635.0" "674.4" "927.3" "772.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8157399823022384529" "False" "High" "IsMasterProtein" "Q99567" "Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2" "0.000" "False" "67.281" "20" "12" "17" "12" "741" "83.5" "5.69" "62.83" "12" "other metabolic processes;transport" "cytosol;nucleus" "other molecular function" "Pf10168" "4927" "ENSG00000108559" "NUP88" "D3DTM2; hsa:4927; Q99567; Q9BWE5" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "Ciliary landscape" "29" "0" "0.991" "0.980" "0.986" "1.023" "1.004" "0.986" "1.054" "1.024" "1.008" "1335.9" "1324.0" "1308.5" "1316.8" "1367.2" "1341.4" "1317.3" "1408.3" "1367.4" "1346.2" "" "" "" "" "" "" "" "" "" "" "1073.0" "955.3" "1039.4" "882.2" "945.6" "1006.4" "922.3" "1028.5" "1367.4" "1094.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647128743561798150" "False" "High" "IsMasterProtein" "P78417" "Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2" "0.000" "False" "67.248" "40" "11" "31" "11" "241" "27.5" "6.60" "94.39" "11" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13409, Pf14497" "9446" "ENSG00000148834" "GSTO1" "D3DRA3; F5H7H0; hsa:9446; P78417; Q5TA03; Q7Z3T2" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Vitamin C (ascorbate) metabolism; Methylation" "Myometrial relaxation and contraction pathways; Arsenic metabolism and reactive oxygen species generation; Metapathway biotransformation Phase I and II" "7" "0" "0.986" "0.993" "0.946" "1.007" "1.000" "0.963" "0.936" "0.937" "0.985" "2219.0" "2188.0" "2202.7" "2099.8" "2234.9" "2218.0" "2137.9" "2077.2" "2078.3" "2185.5" "" "" "" "" "" "" "" "" "" "" "1782.3" "1578.8" "1749.6" "1406.8" "1545.7" "1664.1" "1496.8" "1517.0" "2078.3" "1777.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8474719942598486325" "False" "High" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "0.000" "False" "67.219" "18" "12" "14" "12" "563" "65.1" "5.05" "51.80" "12" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "mRNA Splicing - Major Pathway" "" "1" "0" "0.999" "0.996" "0.986" "0.965" "0.957" "0.952" "1.005" "0.973" "0.973" "1455.1" "1454.3" "1449.5" "1435.4" "1404.1" "1392.9" "1385.1" "1461.8" "1415.7" "1415.8" "" "" "" "" "" "" "" "" "" "" "1168.7" "1049.4" "1151.4" "961.7" "971.1" "1045.0" "969.8" "1067.6" "1415.7" "1151.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307907366133705571" "False" "High" "IsMasterProtein" "Q9UJY4" "ADP-ribosylation factor-binding protein GGA2 OS=Homo sapiens OX=9606 GN=GGA2 PE=1 SV=3" "0.000" "False" "67.163" "20" "10" "13" "10" "613" "67.1" "6.55" "61.80" "10" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23062" "ENSG00000103365" "GGA2" "D3DWF0; hsa:23062; O14564; Q9NYN2; Q9UJY4; Q9UPS2" "Amyloid fiber formation; TBC/RABGAPs" "" "2" "0" "0.974" "1.004" "1.007" "0.960" "0.927" "0.913" "0.930" "0.926" "0.956" "1643.0" "1600.1" "1650.4" "1654.7" "1577.6" "1522.7" "1500.3" "1527.8" "1521.7" "1571.2" "" "" "" "" "" "" "" "" "" "" "1319.6" "1154.6" "1310.9" "1108.7" "1091.1" "1142.4" "1050.4" "1115.7" "1521.7" "1277.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2160825122742080574" "False" "High" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "0.000" "False" "67.118" "39" "10" "28" "7" "271" "30.5" "6.29" "87.55" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Neutrophil degranulation" "Selenium micronutrient network" "2" "0" "1.071" "1.012" "1.004" "1.021" "1.095" "0.980" "1.016" "0.957" "1.049" "551.0" "590.1" "557.8" "553.3" "562.7" "603.4" "539.7" "559.7" "527.3" "578.1" "" "" "" "" "" "" "" "" "" "" "442.6" "425.8" "443.1" "370.7" "389.2" "452.7" "377.9" "408.8" "527.3" "470.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1991199370327280785" "False" "High" "IsMasterProtein" "Q9HD26" "Golgi-associated PDZ and coiled-coil motif-containing protein OS=Homo sapiens OX=9606 GN=GOPC PE=1 SV=1" "0.000" "False" "67.074" "32" "14" "21" "14" "462" "50.5" "5.92" "60.60" "14" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595" "57120" "ENSG00000047932" "GOPC" "A6NM30; hsa:57120; Q59FS4; Q969U8; Q9HD26" "RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking" "" "2" "0" "1.002" "1.027" "1.002" "0.999" "0.973" "0.967" "1.032" "1.028" "0.977" "1421.4" "1424.9" "1459.7" "1425.0" "1420.5" "1383.6" "1374.6" "1467.1" "1461.8" "1389.0" "" "" "" "" "" "" "" "" "" "" "1141.7" "1028.2" "1159.5" "954.7" "982.5" "1038.1" "962.4" "1071.4" "1461.8" "1129.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4879961638611313513" "False" "High" "IsMasterProtein" "Q12765" "Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2" "0.000" "False" "67.070" "29" "10" "19" "10" "414" "46.4" "4.75" "69.57" "10" "protein metabolism;transport;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03577" "9805" "ENSG00000136193" "SCRN1" "A8K0E9; B4DHM0; B4DIP5; C9JPG0; hsa:9805; Q12765; Q25QX7; Q8IWD1" "" "" "0" "0" "0.940" "0.966" "1.024" "1.003" "1.005" "1.021" "0.976" "0.969" "1.000" "1559.9" "1466.4" "1507.0" "1598.0" "1564.5" "1567.6" "1593.1" "1522.0" "1512.3" "1559.6" "" "" "" "" "" "" "" "" "" "" "1252.9" "1058.1" "1197.1" "1070.7" "1082.0" "1176.1" "1115.4" "1111.6" "1512.3" "1268.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1633285367868477603" "False" "High" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "0.000" "False" "67.066" "15" "11" "30" "1" "583" "68.5" "6.37" "98.89" "11" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "Regulation of actin cytoskeleton" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4481377694352566724" "False" "High" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "0.000" "False" "67.054" "29" "9" "22" "8" "316" "35.8" "6.98" "78.36" "9" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Pregnenolone biosynthesis; Fructose biosynthesis" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Omega-6-fatty acids in senescence; Polyol pathway; Metapathway biotransformation Phase I and II" "7" "0" "0.979" "0.973" "0.903" "0.911" "0.958" "0.854" "0.880" "0.863" "0.930" "3024.4" "2962.0" "2942.7" "2730.6" "2756.4" "2897.1" "2583.6" "2660.5" "2609.7" "2812.6" "" "" "" "" "" "" "" "" "" "" "2429.2" "2137.3" "2337.5" "1829.5" "1906.3" "2173.6" "1808.9" "1943.0" "2609.7" "2287.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8760192209186557782" "False" "High" "IsMasterProtein" "Q8NCA5" "Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2" "0.000" "False" "66.853" "18" "6" "9" "5" "518" "55.2" "8.95" "43.33" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "25940" "ENSG00000119812" "FAM98A" "B2RNA2; hsa:25940; Q8NCA5; Q9Y3Y6" "" "" "0" "1" "0.984" "1.004" "1.040" "0.956" "1.041" "1.043" "0.964" "0.996" "1.044" "826.3" "813.2" "829.7" "859.2" "790.1" "860.0" "861.9" "796.2" "822.8" "862.8" "" "" "" "" "" "" "" "" "" "" "663.7" "586.8" "659.0" "575.7" "546.4" "645.2" "603.4" "581.5" "822.8" "701.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7521593605618506386" "False" "High" "IsMasterProtein" "Q02556" "Interferon regulatory factor 8 OS=Homo sapiens OX=9606 GN=IRF8 PE=1 SV=2" "0.000" "False" "66.850" "36" "14" "20" "14" "426" "48.3" "6.77" "62.05" "14" "other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3394" "ENSG00000140968" "IRF8" "A0AV82; hsa:3394; Q02556" "Interferon gamma signaling; Interferon alpha/beta signaling" "Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Extrafollicular and follicular B cell activation by SARS-CoV-2; 2q37 copy number variation syndrome; Type II interferon signaling" "7" "0" "0.971" "0.987" "1.021" "0.952" "0.947" "0.923" "0.919" "0.926" "0.975" "1777.7" "1725.7" "1754.1" "1815.3" "1692.3" "1684.1" "1641.2" "1634.5" "1646.7" "1733.0" "" "" "" "" "" "" "" "" "" "" "1427.8" "1245.2" "1393.3" "1216.2" "1170.4" "1263.6" "1149.1" "1193.7" "1646.7" "1409.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8452919191869770403" "False" "High" "IsMasterProtein" "Q8WVV9" "Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1" "0.000" "False" "66.843" "31" "13" "18" "12" "542" "60.0" "7.72" "65.59" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "92906" "ENSG00000143889" "HNRNPLL" "hsa:92906; Q53T80; Q5JB51; Q5JB52; Q659B9; Q8IVH5; Q8IVH6; Q8WVV9; Q96HR5" "" "" "0" "0" "0.970" "0.945" "0.909" "0.865" "0.874" "0.840" "0.888" "0.913" "0.948" "1146.1" "1111.2" "1083.0" "1041.6" "990.8" "1002.2" "962.5" "1017.2" "1045.9" "1086.6" "" "" "" "" "" "" "" "" "" "" "920.5" "801.8" "860.2" "697.9" "685.3" "752.0" "673.9" "742.8" "1045.9" "883.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8618924530113613764" "False" "High" "IsMasterProtein" "Q9UPT6" "C-Jun-amino-terminal kinase-interacting protein 3 OS=Homo sapiens OX=9606 GN=MAPK8IP3 PE=1 SV=3" "0.000" "False" "66.749" "12" "15" "21" "13" "1336" "147.4" "5.40" "58.41" "15" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "23162" "ENSG00000138834" "MAPK8IP3" "A2A2B3; A7E2B3; hsa:23162; Q96RY4; Q9H4I4; Q9H7P1; Q9NUG0; Q9UPT6" "" "MAPK signaling pathway" "1" "0" "1.010" "0.977" "1.070" "1.051" "1.071" "1.065" "1.054" "1.083" "1.017" "1491.6" "1506.8" "1458.0" "1595.6" "1567.1" "1597.3" "1589.1" "1571.6" "1616.2" "1516.7" "" "" "" "" "" "" "" "" "" "" "1198.1" "1087.3" "1158.1" "1069.0" "1083.8" "1198.4" "1112.6" "1147.7" "1616.2" "1233.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5819226307907089360" "False" "High" "IsMasterProtein" "Q99996" "A-kinase anchor protein 9 OS=Homo sapiens OX=9606 GN=AKAP9 PE=1 SV=4" "0.000" "False" "66.731" "5" "19" "19" "19" "3907" "452.7" "4.98" "59.79" "19" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10495" "10142" "ENSG00000127914" "AKAP9" "A4D1F0; A4D1F2; A4D1F4; hsa:10142; O14869; O43355; O94895; Q75N20; Q99996; Q9UQH3; Q9UQQ4; Q9Y6B8; Q9Y6Y2" "Signaling by BRAF and RAF1 fusions; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Phase 3 - rapid repolarisation; Phase 2 - plateau phase" "G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection" "12" "0" "0.967" "0.953" "1.010" "0.957" "0.994" "1.043" "0.928" "1.010" "0.998" "750.6" "725.5" "715.0" "758.0" "718.5" "746.0" "782.7" "696.7" "757.8" "748.8" "" "" "" "" "" "" "" "" "" "" "602.8" "523.5" "568.0" "507.9" "496.9" "559.7" "548.0" "508.8" "757.8" "609.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3915104900764818222" "False" "High" "IsMasterProtein" "Q86TG7" "Retrotransposon-derived protein PEG10 OS=Homo sapiens OX=9606 GN=PEG10 PE=1 SV=2" "0.000" "False" "66.725" "21" "11" "12" "11" "708" "80.1" "6.39" "51.60" "11" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16297" "23089" "ENSG00000242265" "PEG10" "B4DSP0; hsa:23089; Q86TG7; Q96A68; Q9UPV1" "" "" "0" "0" "1.025" "1.007" "1.057" "1.059" "1.033" "1.099" "1.065" "1.071" "1.066" "1043.8" "1069.6" "1051.2" "1102.9" "1105.7" "1078.6" "1146.9" "1111.9" "1117.9" "1112.7" "" "" "" "" "" "" "" "" "" "" "838.4" "771.8" "835.0" "739.0" "764.7" "809.3" "803.0" "812.0" "1117.9" "904.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "777273144622755670" "False" "High" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "0.000" "False" "66.718" "29" "12" "21" "12" "535" "57.2" "8.28" "64.69" "12" "cell-cell signaling;other metabolic processes;developmental processes" "mitochondrion;other cell component" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Degradation of GABA" "Fragile X syndrome" "2" "0" "0.977" "0.957" "0.928" "0.943" "0.958" "0.894" "0.931" "0.874" "0.889" "2264.5" "2212.2" "2166.1" "2102.3" "2136.1" "2169.4" "2023.4" "2107.5" "1978.4" "2013.7" "" "" "" "" "" "" "" "" "" "" "1818.9" "1596.3" "1720.6" "1408.5" "1477.4" "1627.7" "1416.7" "1539.1" "1978.4" "1637.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042758646776431623" "False" "High" "IsMasterProtein" "Q9UQR0" "Sex comb on midleg-like protein 2 OS=Homo sapiens OX=9606 GN=SCML2 PE=1 SV=1" "0.000" "False" "66.705" "20" "11" "18" "11" "700" "77.2" "8.54" "61.84" "11" "other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820, Pf12140, Pf17208" "10389" "ENSG00000102098" "SCML2" "hsa:10389; Q5JXE6; Q86U98; Q8IWD0; Q8NDP2; Q9UGC5; Q9UQR0" "" "" "0" "0" "0.981" "0.966" "0.980" "0.981" "0.968" "1.003" "0.999" "1.037" "1.010" "1338.8" "1312.9" "1292.7" "1311.9" "1313.5" "1295.7" "1342.3" "1337.3" "1388.5" "1352.4" "" "" "" "" "" "" "" "" "" "" "1075.3" "947.3" "1026.8" "879.0" "908.4" "972.1" "939.8" "976.6" "1388.5" "1099.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6222929657638767461" "False" "High" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "0.000" "False" "66.624" "50" "11" "35" "10" "216" "23.7" "9.41" "98.40" "11" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "4" "0" "0.955" "0.967" "0.984" "1.003" "1.001" "0.998" "0.930" "0.939" "0.971" "2865.6" "2736.9" "2770.1" "2818.6" "2874.8" "2868.3" "2860.4" "2665.6" "2690.0" "2782.3" "" "" "" "" "" "" "" "" "" "" "2301.6" "1974.8" "2200.4" "1888.5" "1988.3" "2152.1" "2002.7" "1946.7" "2690.0" "2262.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8925362845928829320" "False" "High" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "0.000" "False" "66.526" "19" "13" "20" "13" "717" "82.9" "8.12" "67.39" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "1.029" "1.005" "1.041" "1.058" "1.013" "1.064" "0.995" "0.991" "1.017" "1361.5" "1401.5" "1367.6" "1416.7" "1440.3" "1379.1" "1449.1" "1354.6" "1349.0" "1384.6" "" "" "" "" "" "" "" "" "" "" "1093.5" "1011.3" "1086.4" "949.2" "996.1" "1034.7" "1014.6" "989.3" "1349.0" "1126.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629254407620291846" "False" "High" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "0.000" "False" "66.486" "22" "8" "18" "8" "464" "49.2" "9.64" "65.04" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.951" "1.006" "0.935" "0.970" "1.002" "0.967" "1.019" "1.022" "1.031" "1743.1" "1657.9" "1754.1" "1629.7" "1691.3" "1747.0" "1684.7" "1776.2" "1781.1" "1797.1" "" "" "" "" "" "" "" "" "" "" "1400.0" "1196.3" "1393.3" "1091.9" "1169.7" "1310.7" "1179.5" "1297.1" "1781.1" "1461.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3253297407861631258" "False" "High" "IsMasterProtein" "O95155" "Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1" "0.000" "False" "66.463" "13" "13" "16" "12" "1302" "146.1" "6.55" "54.12" "13" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "10277" "ENSG00000130939" "UBE4B" "A8K8S9; G0ZJH6; O75169; O95155; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7" "" "" "0" "0" "1.040" "1.032" "1.036" "1.084" "1.033" "1.107" "1.098" "1.056" "1.024" "863.0" "897.3" "890.8" "893.9" "935.8" "891.4" "955.0" "947.7" "911.2" "884.1" "" "" "" "" "" "" "" "" "" "" "693.2" "647.5" "707.6" "598.9" "647.2" "668.8" "668.7" "692.1" "911.2" "719.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713269859164182683" "False" "High" "IsMasterProtein" "P08567" "Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3" "0.000" "False" "66.451" "28" "7" "17" "7" "350" "40.1" "8.28" "68.30" "7" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00169, Pf00610" "5341" "ENSG00000115956" "PLEK" "B2R9E8; hsa:5341; P08567; Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81" "Platelet degranulation" "Serotonin and anxiety-related events; TYROBP causal network in microglia; Serotonin and anxiety" "4" "0" "1.011" "1.041" "0.942" "0.974" "0.947" "0.949" "0.825" "0.954" "0.979" "780.6" "788.8" "812.3" "735.4" "760.5" "738.9" "740.8" "644.1" "744.9" "764.1" "" "" "" "" "" "" "" "" "" "" "626.9" "569.2" "645.3" "492.7" "526.0" "554.4" "518.7" "470.4" "744.9" "621.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5396921561883894054" "False" "High" "IsMasterProtein" "Q96GD0" "Chronophin OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2" "0.000" "False" "66.439" "45" "11" "15" "11" "296" "31.7" "6.55" "55.14" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13242, Pf13344" "57026" "ENSG00000241360" "PDXP" "hsa:57026; Q96GD0; Q9UGY2" "" "" "0" "0" "0.993" "0.930" "0.964" "0.991" "0.938" "1.004" "0.954" "0.944" "0.971" "949.0" "941.9" "882.7" "914.5" "940.3" "890.4" "952.3" "904.8" "895.4" "921.6" "" "" "" "" "" "" "" "" "" "" "762.2" "679.6" "701.1" "612.7" "650.3" "668.0" "666.7" "660.8" "895.4" "749.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2904127799800100027" "False" "High" "IsMasterProtein" "Q8IYS1" "Xaa-Arg dipeptidase OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2" "0.000" "False" "66.422" "24" "9" "19" "9" "436" "47.7" "5.85" "71.54" "9" "protein metabolism;other biological processes" "nucleus" "other molecular function" "Pf01546, Pf07687" "135293" "ENSG00000146281" "PM20D2" "B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1" "" "" "0" "0" "1.004" "1.036" "0.992" "0.993" "1.019" "0.959" "0.943" "0.996" "0.969" "1917.7" "1924.9" "1986.2" "1902.8" "1903.6" "1954.9" "1839.2" "1808.4" "1909.1" "1858.1" "" "" "" "" "" "" "" "" "" "" "1540.3" "1388.9" "1577.7" "1274.9" "1316.6" "1466.7" "1287.7" "1320.7" "1909.1" "1511.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1528073227460313936" "False" "High" "IsMasterProtein" "Q9H9T3" "Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2" "0.000" "False" "66.343" "24" "11" "15" "11" "547" "62.2" "8.88" "51.40" "11" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04055, Pf16199" "55140" "ENSG00000134014" "ELP3" "B4DE19; B4DIG1; E2QRI5; hsa:55140; Q53G84; Q6AWB0; Q9BVF7; Q9H9T3; Q9NVZ1" "HATs acetylate histones" "Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system" "3" "0" "1.006" "1.007" "1.018" "1.003" "1.026" "0.925" "0.970" "0.967" "0.993" "1607.6" "1617.5" "1618.6" "1636.0" "1612.7" "1650.1" "1487.6" "1560.0" "1554.0" "1596.5" "" "" "" "" "" "" "" "" "" "" "1291.2" "1167.1" "1285.7" "1096.1" "1115.3" "1238.1" "1041.5" "1139.2" "1554.0" "1298.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169835918379755143" "False" "High" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "0.000" "False" "66.269" "35" "10" "30" "7" "249" "28.6" "4.09" "100.40" "10" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "HuR (ELAVL1) binds and stabilizes mRNA" "IL-18 signaling pathway" "2" "3" "1.007" "1.052" "1.092" "0.961" "1.113" "1.130" "1.073" "0.987" "1.042" "2414.4" "2431.8" "2541.0" "2635.9" "2320.0" "2687.1" "2727.5" "2591.9" "2383.6" "2516.3" "" "" "" "" "" "" "" "" "" "" "1939.2" "1754.7" "2018.4" "1766.0" "1604.6" "2016.1" "1909.6" "1892.8" "2383.6" "2046.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002487047349753336" "False" "High" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "0.000" "False" "66.268" "64" "9" "55" "1" "152" "17.3" "8.41" "169.74" "9" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Azathioprine ADME; Neutrophil degranulation; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME" "Pyrimidine metabolism" "5" "8" "0.972" "0.992" "0.976" "0.992" "1.024" "0.973" "0.936" "0.958" "0.999" "5421.2" "5270.5" "5375.9" "5289.1" "5379.0" "5549.7" "5276.3" "5076.0" "5195.7" "5418.2" "" "" "" "" "" "" "" "" "" "" "4354.2" "3803.1" "4270.3" "3543.7" "3720.2" "4163.8" "3694.2" "3707.0" "5195.7" "4406.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2631004439744677845" "False" "High" "IsMasterProtein" "P04637" "Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4" "0.000" "False" "66.229" "36" "13" "18" "13" "393" "43.6" "6.79" "65.08" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00870, Pf07710, Pf08563, Pf18521" "7157" "ENSG00000141510" "TP53" "hsa:7157; P04637; Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98; Q3LRW1; Q3LRW2; Q3LRW3; Q3LRW4; Q3LRW5; Q86UG1; Q8J016; Q99659; Q9BTM4; Q9HAQ8; Q9NP68; Q9NPJ2; Q9NZD0; Q9UBI2; Q9UQ61" "TP53 Regulates Transcription of DNA Repair Genes; Regulation of PTEN gene transcription; Factors involved in megakaryocyte development and platelet production; Zygotic genome activation (ZGA); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-4 and Interleukin-13 signaling; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; Regulation of NF-kappa B signaling; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional activation of cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of prostate cancer signaling pathways; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Hereditary leiomyomatosis and renal cell carcinoma pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in progeria; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; Measles virus infection; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Pleural mesothelioma; Lipid metabolism in senescent cells; DYRK1A involvement regarding cell proliferation in brain development; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma; 11p11.2 copy number variation syndrome ; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "116" "0" "1.025" "1.056" "1.019" "1.006" "1.004" "1.403" "1.511" "1.414" "1.148" "1607.8" "1647.9" "1697.3" "1638.4" "1617.1" "1614.4" "2254.9" "2429.0" "2272.8" "1846.5" "" "" "" "" "" "" "" "" "" "" "1291.4" "1189.1" "1348.2" "1097.8" "1118.4" "1211.2" "1578.8" "1773.9" "2272.8" "1501.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "124053754926249858" "False" "High" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "0.000" "False" "66.206" "16" "12" "17" "11" "871" "97.6" "5.81" "45.04" "12" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.013" "1.038" "1.012" "0.980" "0.943" "0.955" "1.016" "0.985" "0.986" "984.7" "997.1" "1021.9" "996.5" "965.3" "929.0" "940.3" "1000.9" "969.9" "971.2" "" "" "" "" "" "" "" "" "" "" "790.9" "719.5" "811.8" "667.6" "667.6" "697.0" "658.4" "730.9" "969.9" "789.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6313231503744566384" "False" "High" "IsMasterProtein" "O00754" "Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3" "0.000" "False" "66.138" "12" "11" "19" "11" "1011" "113.7" "7.28" "66.76" "11" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf21260" "4125" "ENSG00000104774" "MAN2B1" "G5E928; hsa:4125; O00754; O15330; Q16680; Q93094; Q9BW13" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "" "2" "0" "0.965" "0.982" "0.978" "1.012" "1.018" "0.931" "0.888" "0.925" "1.004" "1373.5" "1325.3" "1349.2" "1342.8" "1390.2" "1398.8" "1279.0" "1219.1" "1270.3" "1378.6" "" "" "" "" "" "" "" "" "" "" "1103.2" "956.3" "1071.7" "899.7" "961.5" "1049.5" "895.5" "890.3" "1270.3" "1121.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650974207865814862" "False" "High" "IsMasterProtein" "P04818" "Thymidylate synthase OS=Homo sapiens OX=9606 GN=TYMS PE=1 SV=3" "0.000" "False" "66.051" "35" "9" "18" "9" "313" "35.7" "7.01" "67.05" "9" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00303" "7298" "ENSG00000176890" "TYMS" "hsa:7298; P04818; Q8WYK3; Q8WYK4" "Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism" "9" "0" "1.057" "1.038" "1.021" "1.057" "1.049" "1.090" "1.107" "1.128" "1.110" "1311.7" "1385.8" "1362.1" "1339.5" "1385.9" "1376.2" "1430.2" "1452.3" "1479.8" "1455.9" "" "" "" "" "" "" "" "" "" "" "1053.5" "1000.0" "1081.9" "897.5" "958.5" "1032.5" "1001.3" "1060.6" "1479.8" "1184.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-466153880284673871" "False" "High" "IsMasterProtein" "Q12873" "Chromodomain-helicase-DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=CHD3 PE=1 SV=3" "0.000" "False" "66.038" "8" "15" "26" "5" "2000" "226.5" "7.30" "76.70" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1107" "ENSG00000170004" "CHD3" "D3DTQ9; E9PG89; hsa:1107; Q12873; Q9Y4I0" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; Regulation of TP53 Activity through Acetylation; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation" "Effect of progerin on genes involved in progeria" "8" "0" "1.136" "1.096" "1.131" "0.965" "0.996" "0.980" "1.083" "1.182" "0.953" "316.2" "359.2" "346.4" "357.7" "305.0" "315.0" "309.8" "342.3" "373.7" "301.4" "" "" "" "" "" "" "" "" "" "" "254.0" "259.2" "275.2" "239.6" "211.0" "236.3" "216.9" "250.0" "373.7" "245.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8721939623497573862" "False" "High" "IsMasterProtein" "Q86YV5" "Inactive tyrosine-protein kinase PRAG1 OS=Homo sapiens OX=9606 GN=PRAG1 PE=1 SV=4" "0.000" "False" "65.876" "13" "13" "15" "13" "1406" "149.5" "7.20" "50.65" "13" "other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "157285" "ENSG00000275342" "PRAG1" "Q86YV5; Q8N3N5" "RND2 GTPase cycle" "" "1" "0" "1.052" "0.943" "1.071" "1.003" "1.005" "1.041" "0.982" "1.029" "1.026" "765.7" "805.3" "721.8" "819.8" "768.1" "769.2" "797.0" "752.2" "787.8" "785.3" "" "" "" "" "" "" "" "" "" "" "615.0" "581.1" "573.3" "549.3" "531.3" "577.1" "558.1" "549.3" "787.8" "638.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "61926280635528933" "False" "High" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "0.000" "False" "65.842" "12" "17" "26" "12" "1362" "152.1" "9.19" "81.32" "17" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "Potential therapeutics for SARS" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "3" "4" "1.026" "0.999" "0.994" "1.033" "1.017" "0.996" "1.005" "1.006" "1.017" "2031.4" "2084.9" "2030.1" "2019.3" "2099.4" "2066.2" "2023.5" "2042.5" "2042.7" "2065.3" "" "" "" "" "" "" "" "" "" "" "1631.6" "1504.4" "1612.6" "1352.9" "1452.0" "1550.2" "1416.8" "1491.6" "2042.7" "1679.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1824011876683044668" "False" "High" "IsMasterProtein" "Q9ULA0" "Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2" "0.000" "False" "65.838" "22" "9" "14" "9" "485" "53.4" "7.58" "49.75" "9" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02127" "23549" "ENSG00000123992" "DNPEP" "hsa:23549; Q9BW44; Q9NUV5; Q9NV55; Q9ULA0" "" "Ciliary landscape" "1" "0" "0.998" "0.988" "1.026" "1.065" "1.032" "0.990" "0.956" "0.990" "1.000" "971.1" "969.2" "959.3" "996.3" "1034.2" "1001.7" "961.5" "928.3" "961.5" "971.5" "" "" "" "" "" "" "" "" "" "" "780.0" "699.3" "762.0" "667.5" "715.3" "751.6" "673.2" "677.9" "961.5" "790.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3305508852960409357" "False" "High" "IsMasterProtein" "Cont_Q7SIH1" "Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2" "0.000" "True" "65.836" "11" "16" "18" "16" "1510" "167.5" "6.02" "56.87" "16" "" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791" "513856" "" "A2M" "A8E647; bta:513856; Q7SIH1" "" "" "0" "0" "1.069" "0.881" "1.123" "1.010" "1.042" "1.398" "0.980" "1.001" "1.052" "2059.8" "2201.9" "1814.8" "2312.5" "2081.3" "2146.6" "2879.5" "2018.2" "2060.8" "2166.3" "" "" "" "" "" "" "" "" "" "" "1654.4" "1588.8" "1441.6" "1549.4" "1439.4" "1610.6" "2016.1" "1473.9" "2060.8" "1761.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960640284500961057" "False" "High" "IsMasterProtein" "Q13426" "DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2" "0.000" "False" "65.780" "36" "11" "15" "11" "336" "38.3" "4.98" "54.49" "11" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06632" "7518" "ENSG00000152422" "XRCC4" "A8K3X4; hsa:7518; Q13426; Q9BS72; Q9UP94" "SUMOylation of DNA damage response and repair proteins; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "7" "0" "0.973" "0.986" "0.970" "1.046" "1.054" "1.013" "0.993" "1.041" "1.006" "1008.8" "982.0" "994.5" "978.6" "1054.9" "1063.2" "1022.2" "1001.6" "1050.6" "1014.5" "" "" "" "" "" "" "" "" "" "" "810.3" "708.6" "789.9" "655.7" "729.6" "797.7" "715.7" "731.5" "1050.6" "825.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5875685193594640149" "False" "High" "IsMasterProtein" "Q7Z3U7" "Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3" "0.000" "False" "65.758" "9" "16" "18" "16" "1717" "190.2" "6.06" "59.08" "16" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf09324, Pf12783, Pf16206, Pf16213" "23041" "ENSG00000061987" "MON2" "A5D8U7; A7E2Y0; B9EGP5; F8VWA6; F8W1Z6; hsa:23041; Q7Z3U7; Q86TA2; Q8N3I5; Q8NAI0; Q8NHE2; Q9UPW1" "" "" "0" "0" "1.032" "1.031" "1.021" "1.101" "1.036" "1.044" "1.064" "1.072" "1.076" "1682.2" "1736.1" "1735.2" "1718.0" "1852.7" "1743.4" "1756.1" "1790.1" "1803.8" "1810.7" "" "" "" "" "" "" "" "" "" "" "1351.2" "1252.7" "1378.3" "1151.1" "1281.3" "1308.0" "1229.5" "1307.3" "1803.8" "1472.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948435004993003441" "False" "High" "IsMasterProtein" "P52594" "Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2" "0.000" "False" "65.665" "22" "9" "14" "9" "562" "58.2" "8.63" "61.61" "9" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01412" "3267" "ENSG00000173744" "AGFG1" "B3KUL1; E9PHX7; hsa:3267; P52594; Q15277; Q4VAS0; Q4VAS1; Q4VAS3; Q53QT8; Q53R11" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "1.035" "0.988" "0.986" "0.975" "1.018" "1.040" "1.041" "0.937" "1.022" "742.6" "768.3" "733.4" "732.0" "724.2" "755.9" "772.4" "773.3" "695.6" "758.8" "" "" "" "" "" "" "" "" "" "" "596.4" "554.4" "582.6" "490.5" "500.8" "567.1" "540.8" "564.8" "695.6" "617.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8730523960052608716" "False" "High" "IsMasterProtein" "O60879" "Protein diaphanous homolog 2 OS=Homo sapiens OX=9606 GN=DIAPH2 PE=1 SV=1" "0.000" "False" "65.654" "14" "15" "19" "15" "1101" "125.5" "6.58" "66.04" "15" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "1730" "ENSG00000147202" "DIAPH2" "A6NG19; hsa:1730; O60878; O60879; Q8WX06; Q8WX48; Q9UJL2" "RHOF GTPase cycle" "Primary ovarian insufficiency" "2" "0" "1.009" "1.013" "1.034" "1.006" "1.009" "0.970" "1.025" "1.067" "1.056" "1662.9" "1677.8" "1684.2" "1718.9" "1672.6" "1677.7" "1612.5" "1703.7" "1774.7" "1755.9" "" "" "" "" "" "" "" "" "" "" "1335.6" "1210.6" "1337.8" "1151.7" "1156.8" "1258.8" "1129.0" "1244.2" "1774.7" "1428.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2292593222020041360" "False" "High" "IsMasterProtein" "Q92925" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3" "0.000" "False" "65.650" "30" "14" "20" "12" "531" "58.9" "9.64" "75.04" "14" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02201" "6603" "ENSG00000108604" "SMARCD2" "A5PLL5; A6NNQ7; B4DV56; B4E1R6; hsa:6603; Q7L2I6; Q92925; Q9UHZ1" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "1" "1.026" "1.016" "1.041" "0.922" "0.957" "0.937" "0.983" "0.971" "0.934" "1338.7" "1373.3" "1360.2" "1393.1" "1234.9" "1280.6" "1254.6" "1316.3" "1300.1" "1250.7" "" "" "" "" "" "" "" "" "" "" "1075.2" "991.0" "1080.4" "933.3" "854.0" "960.8" "878.4" "961.3" "1300.1" "1017.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662139928789152118" "False" "High" "IsMasterProtein" "Q8WYJ6" "Septin-1 OS=Homo sapiens OX=9606 GN=SEPTIN1 PE=1 SV=3" "0.000" "False" "65.631" "42" "13" "19" "13" "372" "42.4" "5.80" "59.35" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "1731" "ENSG00000180096" "SEPTIN1" "B4DVE6; hsa:1731; Q658T1; Q8NEZ1; Q8WYJ6; Q96EL4; Q9H285" "" "" "0" "0" "1.089" "1.058" "1.067" "1.077" "1.042" "1.051" "1.011" "0.973" "1.062" "859.0" "935.7" "908.4" "916.8" "925.5" "894.8" "902.9" "868.7" "836.2" "912.1" "" "" "" "" "" "" "" "" "" "" "689.9" "675.2" "721.6" "614.2" "640.1" "671.4" "632.2" "634.4" "836.2" "741.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4621514541592481866" "False" "High" "IsMasterProtein" "O75376" "Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2" "0.000" "False" "65.566" "8" "16" "17" "15" "2440" "270.0" "7.11" "51.76" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9611" "ENSG00000141027" "NCOR1" "B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18" "HDACs deacetylate histones; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome; 22q11.2 copy number variation syndrome; Notch signaling pathway" "30" "0" "0.920" "0.856" "0.965" "0.895" "1.030" "0.909" "0.888" "0.891" "0.900" "1295.6" "1192.3" "1109.4" "1249.9" "1159.0" "1334.5" "1178.3" "1150.3" "1154.0" "1166.6" "" "" "" "" "" "" "" "" "" "" "1040.6" "860.3" "881.3" "837.4" "801.6" "1001.3" "825.0" "840.1" "1154.0" "948.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "173468840260374204" "False" "High" "IsMasterProtein" "Q86WB0" "Zinc finger C3HC-type protein 1 OS=Homo sapiens OX=9606 GN=ZC3HC1 PE=1 SV=1" "0.000" "False" "65.532" "29" "10" "13" "10" "502" "55.2" "5.62" "46.91" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf07967, Pf08600" "51530" "ENSG00000091732" "ZC3HC1" "A6NH66; hsa:51530; Q75MF3; Q75MF4; Q86WB0; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0" "Nuclear events stimulated by ALK signaling in cancer" "" "1" "0" "1.078" "1.064" "1.042" "1.048" "1.027" "1.002" "1.049" "1.064" "1.029" "1181.2" "1273.0" "1256.9" "1231.0" "1237.7" "1213.5" "1183.6" "1239.0" "1257.3" "1215.9" "" "" "" "" "" "" "" "" "" "" "948.8" "918.6" "998.4" "824.8" "856.0" "910.5" "828.7" "904.9" "1257.3" "988.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669719094448447392" "False" "High" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "0.000" "False" "65.525" "9" "8" "11" "8" "1104" "122.8" "5.83" "48.83" "8" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Glycosphingolipid transport; RHOF GTPase cycle" "" "7" "0" "1.092" "1.011" "1.163" "1.115" "0.972" "1.151" "1.132" "1.046" "1.060" "901.0" "984.2" "911.3" "1047.4" "1004.4" "875.8" "1037.4" "1020.0" "942.5" "955.2" "" "" "" "" "" "" "" "" "" "" "723.6" "710.2" "723.9" "701.8" "694.7" "657.1" "726.4" "744.9" "942.5" "776.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9134021061211319467" "False" "High" "IsMasterProtein" "Q9HA77" "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" "0.000" "False" "65.468" "24" "11" "16" "11" "564" "62.2" "8.34" "54.15" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01406" "79587" "ENSG00000134905" "CARS2" "hsa:79587; Q8NI84; Q96IV4; Q9HA77" "Mitochondrial tRNA aminoacylation" "" "1" "0" "0.966" "0.969" "1.004" "1.025" "0.982" "0.926" "0.984" "0.970" "0.994" "1214.0" "1172.9" "1176.6" "1219.2" "1244.2" "1192.2" "1124.1" "1194.1" "1177.5" "1206.5" "" "" "" "" "" "" "" "" "" "" "975.1" "846.4" "934.6" "816.9" "860.5" "894.5" "787.1" "872.0" "1177.5" "981.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1241863298076822509" "False" "High" "IsMasterProtein" "Q5VUA4" "Zinc finger protein 318 OS=Homo sapiens OX=9606 GN=ZNF318 PE=1 SV=2" "0.000" "False" "65.456" "6" "12" "14" "12" "2279" "251.0" "7.20" "50.50" "12" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "24149" "ENSG00000171467" "ZNF318" "hsa:24149; O94796; Q4G0E4; Q5VUA4; Q8NEM6; Q9UNU8; Q9Y2W9" "" "Androgen receptor signaling pathway" "1" "0" "1.069" "1.075" "1.011" "1.038" "1.024" "1.044" "1.156" "1.092" "1.053" "685.8" "733.1" "737.5" "693.3" "711.9" "701.9" "715.7" "793.1" "748.6" "722.0" "" "" "" "" "" "" "" "" "" "" "550.8" "529.0" "585.8" "464.5" "492.3" "526.6" "501.1" "579.2" "748.6" "587.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629403927496459035" "False" "High" "IsMasterProtein" "P62987" "Ubiquitin-ribosomal protein eL40 fusion protein OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2" "0.000" "False" "65.454" "49" "8" "146" "1" "128" "14.7" "9.83" "454.67" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01020" "7311" "ENSG00000221983" "UBA52" "hsa:7311; P02248; P02249; P02250; P14793; P62987; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "Major pathway of rRNA processing in the nucleolus and cytosol; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Circadian Clock; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PLK1 Activity at G2/M Transition; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Ovarian tumor domain proteases; FCERI mediated NF-kB activation; Regulation of signaling by CBL; Cyclin D associated events in G1; Inactivation of CSF3 (G-CSF) signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Regulation of innate immune responses to cytosolic DNA; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; VLDLR internalisation and degradation; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Aggrephagy; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 HD Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; HDR through Homologous Recombination (HRR); TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Downregulation of ERBB4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "DNA replication; Cytoplasmic ribosomal proteins" "199" "0" "0.932" "1.086" "1.348" "1.358" "1.583" "1.866" "1.676" "1.371" "1.285" "164.6" "153.4" "178.7" "221.8" "223.5" "260.6" "307.2" "275.9" "225.7" "211.4" "" "" "" "" "" "" "" "" "" "" "132.2" "110.7" "142.0" "148.6" "154.6" "195.5" "215.1" "201.5" "225.7" "172.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6355678057945092611" "False" "High" "IsMasterProtein" "P42695" "Condensin-2 complex subunit D3 OS=Homo sapiens OX=9606 GN=NCAPD3 PE=1 SV=2" "0.000" "False" "65.439" "12" "15" "18" "15" "1498" "168.8" "7.50" "60.67" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12717" "23310" "ENSG00000151503" "NCAPD3" "A6NFS2; hsa:23310; P42695; Q4KMQ9" "Condensation of Prophase Chromosomes" "" "1" "0" "1.023" "0.971" "0.943" "0.974" "0.975" "0.997" "1.046" "1.065" "1.010" "1147.9" "1174.0" "1114.0" "1081.9" "1117.8" "1119.4" "1144.1" "1200.1" "1223.0" "1159.2" "" "" "" "" "" "" "" "" "" "" "921.9" "847.2" "884.9" "724.9" "773.1" "839.8" "801.0" "876.4" "1223.0" "942.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2458252490920426752" "False" "High" "IsMasterProtein" "P16402" "Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2" "0.000" "False" "65.404" "31" "8" "38" "1" "221" "22.3" "11.02" "119.92" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3007" "ENSG00000124575" "H1-3" "B2R751; hsa:3007; P16402; Q2M2I2" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "0" "1.067" "1.181" "1.128" "0.892" "1.076" "0.924" "0.914" "0.809" "1.012" "207.8" "221.8" "245.5" "234.4" "185.4" "223.6" "192.0" "190.1" "168.1" "210.3" "" "" "" "" "" "" "" "" "" "" "166.9" "160.0" "195.0" "157.0" "128.2" "167.8" "134.5" "138.8" "168.1" "171.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4578961420069997890" "False" "High" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "0.000" "False" "65.383" "33" "11" "14" "10" "480" "52.6" "6.37" "51.70" "11" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "0.998" "0.983" "1.061" "0.956" "1.005" "1.120" "1.118" "1.033" "1.048" "817.9" "816.0" "804.4" "868.2" "781.7" "822.4" "916.4" "914.5" "844.5" "857.5" "" "" "" "" "" "" "" "" "" "" "657.0" "588.8" "639.0" "581.7" "540.6" "617.0" "641.6" "667.9" "844.5" "697.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6626039175338175676" "False" "High" "IsMasterProtein" "Q9NXH9" "tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1" "0.000" "False" "65.230" "21" "13" "19" "13" "659" "72.2" "7.64" "55.65" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf02005" "55621" "ENSG00000104907" "TRMT1" "hsa:55621; O76103; Q548Y5; Q8WVA6; Q9NXH9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.035" "1.010" "1.081" "1.020" "0.973" "0.997" "1.017" "0.947" "1.023" "1052.1" "1088.8" "1062.7" "1137.6" "1073.3" "1023.6" "1048.7" "1070.3" "996.0" "1076.5" "" "" "" "" "" "" "" "" "" "" "845.0" "785.6" "844.1" "762.2" "742.3" "768.0" "734.3" "781.7" "996.0" "875.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844416647535235754" "False" "High" "IsMasterProtein" "O00233" "26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3" "0.000" "False" "65.065" "43" "10" "22" "10" "223" "24.7" "6.95" "74.24" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf17820, Pf18265" "5715" "ENSG00000110801" "PSMD9" "B2RD35; G3V1Q6; hsa:5715; O00233; Q9BQ42" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "63" "0" "1.116" "1.101" "1.085" "1.115" "1.057" "1.059" "1.111" "1.069" "1.056" "1680.8" "1875.7" "1851.2" "1822.9" "1874.7" "1776.8" "1780.7" "1866.8" "1795.9" "1774.5" "" "" "" "" "" "" "" "" "" "" "1350.0" "1353.5" "1470.4" "1221.4" "1296.5" "1333.1" "1246.7" "1363.4" "1795.9" "1443.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "364086976847350379" "False" "High" "IsMasterProtein" "Q7L592" "Protein arginine methyltransferase NDUFAF7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF7 PE=1 SV=1" "0.000" "False" "65.063" "33" "11" "15" "11" "441" "49.2" "8.34" "49.47" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf02636" "55471" "ENSG00000003509" "NDUFAF7" "hsa:55471; Q7L592; Q7Z399; Q9P1G3" "Complex I biogenesis" "" "1" "0" "0.989" "0.972" "1.015" "1.037" "1.024" "1.008" "1.032" "1.011" "1.058" "820.0" "810.9" "797.0" "832.3" "850.4" "839.6" "826.9" "846.5" "828.8" "867.6" "" "" "" "" "" "" "" "" "" "" "658.6" "585.2" "633.0" "557.6" "588.1" "630.0" "578.9" "618.2" "828.8" "705.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822975009015350041" "False" "High" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "0.000" "False" "65.041" "37" "14" "18" "14" "445" "52.2" "6.04" "54.14" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440, Pf21357" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.922" "1.101" "0.989" "0.993" "1.031" "1.042" "0.997" "1.016" "1.004" "1489.8" "1373.2" "1640.3" "1473.8" "1478.9" "1536.5" "1552.1" "1486.0" "1513.9" "1495.4" "" "" "" "" "" "" "" "" "" "" "1196.6" "990.8" "1302.9" "987.5" "1022.8" "1152.8" "1086.7" "1085.2" "1513.9" "1216.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3193827358447086587" "False" "High" "IsMasterProtein" "P20936" "Ras GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RASA1 PE=1 SV=1" "0.000" "False" "65.024" "11" "10" "12" "10" "1047" "116.3" "6.54" "43.92" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00616" "5921" "ENSG00000145715" "RASA1" "B2R6W3; B4DTL2; hsa:5921; P20936; Q68CU6; Q9UDI1" "Regulation of RAS by GAPs; EPHB-mediated forward signaling; Downstream signal transduction; VEGFR2 mediated cell proliferation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "Androgen receptor network in prostate cancer; PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; PDGFR-beta pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; GDNF signaling; EPO receptor signaling" "17" "0" "1.017" "1.032" "1.153" "1.077" "0.971" "1.024" "0.998" "0.969" "1.065" "945.1" "961.2" "975.3" "1089.7" "1017.8" "917.7" "967.8" "943.5" "915.3" "1006.2" "" "" "" "" "" "" "" "" "" "" "759.1" "693.6" "774.7" "730.1" "703.9" "688.6" "677.6" "689.1" "915.3" "818.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5797798922783167285" "False" "High" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "0.000" "False" "65.001" "24" "11" "19" "11" "513" "57.5" "7.18" "59.85" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "mRNA Splicing - Major Pathway" "" "1" "0" "0.947" "0.978" "1.030" "1.115" "1.063" "1.069" "0.940" "1.012" "1.014" "1106.5" "1048.4" "1082.0" "1140.1" "1233.8" "1176.6" "1183.1" "1039.9" "1119.6" "1121.8" "" "" "" "" "" "" "" "" "" "" "888.7" "756.5" "859.4" "763.9" "853.3" "882.8" "828.4" "759.4" "1119.6" "912.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9179155935409940173" "False" "High" "IsMasterProtein" "Q15750" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens OX=9606 GN=TAB1 PE=1 SV=1" "0.000" "False" "64.940" "31" "11" "13" "11" "504" "54.6" "5.52" "45.80" "11" "developmental processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "10454" "ENSG00000100324" "TAB1" "hsa:10454; Q15750; Q2PP09; Q8IZW2" "Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; TGF-beta signaling pathway; MAPK signaling pathway; TLR4 signaling and tolerance; miRNA role in immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; Toll-like receptor signaling pathway" "27" "0" "0.984" "0.991" "1.048" "1.042" "1.007" "0.978" "1.008" "0.998" "1.058" "643.6" "633.1" "637.9" "674.7" "670.4" "648.4" "629.6" "648.9" "642.0" "680.9" "" "" "" "" "" "" "" "" "" "" "516.9" "456.8" "506.7" "452.0" "463.7" "486.5" "440.8" "473.9" "642.0" "553.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7990537509462567326" "False" "High" "IsMasterProtein" "P16298" "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2" "0.000" "False" "64.879" "21" "10" "20" "5" "524" "59.0" "5.91" "66.97" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5532" "ENSG00000107758" "PPP3CB" "hsa:5532; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; ROBO receptors bind AKAP5" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "16" "0" "1.026" "0.967" "0.994" "1.026" "0.980" "1.044" "0.900" "0.991" "1.004" "468.5" "480.8" "453.2" "465.6" "480.6" "459.3" "489.0" "421.6" "464.3" "470.6" "" "" "" "" "" "" "" "" "" "" "376.3" "346.9" "360.0" "311.9" "332.4" "344.6" "342.4" "307.9" "464.3" "382.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864595288643475005" "False" "High" "IsMasterProtein" "P61011" "Signal recognition particle subunit SRP54 OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1" "0.000" "False" "64.814" "30" "12" "14" "12" "504" "55.7" "8.75" "46.02" "12" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00448, Pf02881, Pf02978" "6729" "ENSG00000100883" "SRP54" "B2R759; B4DUW6; hsa:6729; P13624; P61011" "SRP-dependent cotranslational protein targeting to membrane" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "0.998" "1.020" "1.080" "1.037" "1.034" "0.972" "1.144" "1.071" "1.039" "1539.1" "1535.6" "1570.5" "1662.5" "1595.6" "1591.4" "1495.8" "1760.0" "1648.0" "1598.6" "" "" "" "" "" "" "" "" "" "" "1236.2" "1108.0" "1247.5" "1113.9" "1103.5" "1194.0" "1047.3" "1285.3" "1648.0" "1300.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2874165042467263127" "False" "High" "IsMasterProtein" "Q6PJG6" "BRCA1-associated ATM activator 1 OS=Homo sapiens OX=9606 GN=BRAT1 PE=1 SV=2" "0.000" "False" "64.785" "15" "11" "16" "11" "821" "88.1" "5.27" "58.05" "11" "cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf02985" "221927" "ENSG00000106009" "BRAT1" "A4D200; C9JY24; hsa:221927; Q6PJG6; Q8IW85; Q8IZ43; Q8WVR8; Q96IV9; Q9H7J8; Q9UFA3" "" "" "0" "0" "1.030" "1.073" "1.041" "1.091" "0.999" "1.049" "1.130" "1.042" "1.003" "595.3" "612.9" "638.9" "619.7" "649.4" "594.7" "624.7" "672.6" "620.1" "597.0" "" "" "" "" "" "" "" "" "" "" "478.2" "442.3" "507.5" "415.2" "449.1" "446.2" "437.4" "491.2" "620.1" "485.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088218542987526353" "False" "High" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "0.000" "False" "64.754" "26" "10" "14" "10" "469" "51.3" "5.58" "58.84" "10" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Polymerase switching on the C-strand of the telomere; Polymerase switching" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "25" "0" "1.020" "0.980" "1.057" "1.010" "0.999" "0.955" "0.990" "0.996" "1.016" "1267.1" "1292.1" "1242.4" "1339.6" "1279.6" "1265.5" "1210.1" "1253.9" "1262.6" "1287.9" "" "" "" "" "" "" "" "" "" "" "1017.7" "932.3" "986.9" "897.6" "885.0" "949.5" "847.2" "915.7" "1262.6" "1047.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2241526083572897290" "False" "High" "IsMasterProtein" "Q9ULX6" "A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4" "0.000" "False" "64.703" "21" "11" "15" "11" "646" "71.6" "5.05" "50.64" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "26993" "ENSG00000011243" "AKAP8L" "B4DJ74; B5BU90; hsa:26993; O94792; Q96J58; Q9NRQ0; Q9UGM0; Q9ULX6" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "0.994" "0.982" "0.905" "0.944" "0.972" "1.026" "1.047" "1.011" "0.979" "808.7" "803.6" "793.8" "732.1" "763.1" "785.9" "829.7" "846.4" "817.6" "791.9" "" "" "" "" "" "" "" "" "" "" "649.5" "579.9" "630.5" "490.5" "527.7" "589.7" "580.9" "618.1" "817.6" "644.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1870630596764229112" "False" "High" "IsMasterProtein" "Q15643" "Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3" "0.000" "False" "64.679" "9" "17" "20" "17" "1979" "227.4" "5.26" "56.67" "17" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytoskeleton;ER/Golgi" "other molecular function" "" "9321" "ENSG00000100815" "TRIP11" "B2RUT2; hsa:9321; O14689; O15154; O95949; Q15643; Q6MZL5" "Intraflagellar transport; Intra-Golgi traffic; Signaling by FLT3 fusion proteins" "" "3" "0" "1.013" "0.989" "1.047" "1.023" "0.986" "0.934" "0.955" "0.973" "1.029" "1500.7" "1520.9" "1484.7" "1570.9" "1535.6" "1479.6" "1402.4" "1433.2" "1460.7" "1544.2" "" "" "" "" "" "" "" "" "" "" "1205.3" "1097.4" "1179.4" "1052.5" "1062.0" "1110.1" "981.9" "1046.7" "1460.7" "1255.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100342078982033337" "False" "High" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "0.000" "False" "64.657" "32" "14" "21" "14" "471" "52.0" "8.00" "61.63" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "RHOBTB1 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "" "5" "0" "0.998" "1.049" "1.021" "1.024" "1.028" "1.075" "1.058" "1.094" "1.022" "744.0" "742.3" "780.0" "759.6" "761.6" "764.4" "799.6" "787.4" "813.6" "760.5" "" "" "" "" "" "" "" "" "" "" "597.5" "535.6" "619.6" "509.0" "526.7" "573.5" "559.8" "575.0" "813.6" "618.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216931438576770944" "False" "High" "IsMasterProtein" "Q9UK76" "Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3" "0.000" "False" "64.623" "55" "7" "25" "7" "154" "16.0" "5.60" "91.92" "7" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf17054" "51155" "ENSG00000189159" "JPT1" "B2R6K3; hsa:51155; Q53FG7; Q7Z2D2; Q7Z2F0; Q9UK76" "" "" "0" "0" "1.053" "0.961" "1.110" "1.104" "1.032" "1.059" "1.003" "1.033" "1.030" "1660.1" "1748.7" "1596.0" "1843.2" "1832.0" "1713.0" "1757.7" "1664.8" "1714.9" "1710.6" "" "" "" "" "" "" "" "" "" "" "1333.4" "1261.8" "1267.8" "1234.9" "1267.0" "1285.3" "1230.6" "1215.8" "1714.9" "1391.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174171264893505362" "False" "High" "IsMasterProtein" "Q9H2J4" "Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1" "0.000" "False" "64.578" "42" "8" "16" "8" "239" "27.6" "4.84" "56.01" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02114" "79031" "ENSG00000115539" "PDCL3" "B2RA00; hsa:79031; Q53S68; Q9H2J4" "" "" "0" "0" "1.057" "1.043" "0.992" "0.988" "1.014" "0.964" "0.961" "1.011" "1.030" "1363.8" "1441.3" "1422.8" "1352.3" "1347.7" "1382.4" "1314.0" "1311.2" "1379.3" "1405.0" "" "" "" "" "" "" "" "" "" "" "1095.4" "1040.0" "1130.2" "906.1" "932.1" "1037.2" "920.0" "957.6" "1379.3" "1142.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291285492636401918" "False" "High" "IsMasterProtein" "Q9H974" "Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1" "0.000" "False" "64.559" "28" "9" "14" "9" "415" "46.7" "6.81" "63.44" "9" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01702" "79691" "ENSG00000151576" "QTRT2" "A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.043" "1.066" "1.024" "0.963" "1.051" "0.968" "0.961" "0.990" "1.023" "666.9" "695.5" "710.6" "682.9" "642.5" "701.0" "645.6" "640.7" "660.4" "682.0" "" "" "" "" "" "" "" "" "" "" "535.6" "501.8" "564.5" "457.6" "444.4" "525.9" "452.0" "467.9" "660.4" "554.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3800161177308876944" "False" "High" "IsMasterProtein" "Q8NEM2" "SHC SH2 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SHCBP1 PE=1 SV=3" "0.000" "False" "64.380" "21" "12" "13" "12" "672" "75.6" "4.75" "40.97" "12" "signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13229" "79801" "ENSG00000171241" "SHCBP1" "hsa:79801; Q8NEM2; Q96N60; Q9BVS0; Q9H6P6" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "0.955" "0.958" "1.005" "0.967" "0.933" "0.946" "1.084" "0.994" "1.012" "1260.3" "1203.9" "1206.9" "1266.6" "1219.4" "1176.4" "1192.1" "1366.8" "1252.2" "1275.6" "" "" "" "" "" "" "" "" "" "" "1012.3" "868.7" "958.7" "848.6" "843.3" "882.6" "834.6" "998.2" "1252.2" "1037.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4163681238843766636" "False" "High" "IsMasterProtein" "Q13144" "Translation initiation factor eIF2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "0.000" "False" "64.322" "16" "9" "13" "9" "721" "80.3" "5.08" "53.39" "9" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Recycling of eIF2:GDP" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "5" "0" "1.001" "0.994" "1.003" "0.968" "0.959" "0.944" "0.950" "0.955" "0.955" "1472.0" "1473.9" "1463.5" "1476.3" "1425.1" "1412.2" "1389.4" "1398.6" "1405.7" "1405.6" "" "" "" "" "" "" "" "" "" "" "1182.3" "1063.5" "1162.5" "989.1" "985.6" "1059.6" "972.8" "1021.4" "1405.7" "1143.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4027474892696141167" "False" "High" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "0.000" "False" "64.278" "24" "9" "14" "9" "483" "57.7" "9.48" "50.96" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "6" "0" "1.052" "1.058" "1.008" "0.992" "1.009" "1.046" "1.032" "1.061" "1.031" "1410.9" "1483.8" "1492.7" "1422.1" "1400.1" "1423.6" "1475.9" "1456.4" "1497.2" "1455.0" "" "" "" "" "" "" "" "" "" "" "1133.2" "1070.7" "1185.7" "952.8" "968.3" "1068.1" "1033.3" "1063.6" "1497.2" "1183.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579275288277334412" "False" "High" "IsMasterProtein" "P46736" "Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2" "0.000" "False" "64.265" "35" "9" "14" "9" "316" "36.0" "5.92" "52.12" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf18110" "79184" "ENSG00000185515" "BRCC3" "A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; hsa:79184; P46736; Q16107; Q53YX5; Q9BTZ6" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "5q35 copy number variation" "6" "0" "1.042" "1.035" "1.081" "1.075" "1.020" "1.067" "0.981" "0.989" "1.056" "840.5" "875.9" "870.1" "908.6" "903.9" "857.5" "896.6" "824.5" "831.3" "887.2" "" "" "" "" "" "" "" "" "" "" "675.1" "632.0" "691.1" "608.8" "625.2" "643.3" "627.7" "602.2" "831.3" "721.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5048841209035306562" "False" "High" "IsMasterProtein" "Q9H845" "Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1" "0.000" "False" "64.174" "21" "11" "12" "11" "621" "68.7" "7.96" "44.29" "11" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "28976" "ENSG00000177646" "ACAD9" "D3DNB8; hsa:28976; Q8WXX3; Q9H845" "Complex I biogenesis" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "3" "0" "0.918" "0.893" "0.963" "1.009" "0.933" "0.985" "0.970" "0.929" "0.966" "536.8" "492.6" "479.4" "516.8" "541.8" "500.8" "528.5" "520.9" "498.6" "518.8" "" "" "" "" "" "" "" "" "" "" "431.1" "355.5" "380.8" "346.3" "374.7" "375.8" "370.1" "380.4" "498.6" "421.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6447964159336659836" "False" "High" "IsMasterProtein" "Q9UL15" "BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1" "0.000" "False" "64.166" "25" "9" "19" "9" "447" "51.2" "6.05" "50.85" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02179" "9529" "ENSG00000166170" "BAG5" "hsa:9529; O94950; Q86W59; Q9UL15" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.991" "0.988" "1.009" "1.030" "1.046" "1.063" "0.997" "1.061" "1.069" "1756.7" "1740.6" "1735.1" "1772.0" "1810.1" "1837.7" "1866.7" "1750.8" "1863.2" "1877.5" "" "" "" "" "" "" "" "" "" "" "1411.0" "1255.9" "1378.2" "1187.3" "1251.9" "1378.8" "1307.0" "1278.6" "1863.2" "1526.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3853404113387134869" "False" "High" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "0.000" "False" "64.156" "25" "11" "17" "11" "544" "61.5" "5.47" "50.91" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "0.979" "0.971" "0.955" "0.994" "0.994" "0.982" "1.036" "0.947" "1.008" "892.2" "873.8" "866.5" "852.0" "887.1" "886.9" "876.1" "924.2" "845.3" "899.0" "" "" "" "" "" "" "" "" "" "" "716.6" "630.5" "688.3" "570.9" "613.5" "665.4" "613.4" "675.0" "845.3" "731.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7568231581715943755" "False" "High" "IsMasterProtein" "Q7Z333" "Probable helicase senataxin OS=Homo sapiens OX=9606 GN=SETX PE=1 SV=4" "0.000" "False" "64.149" "7" "19" "20" "19" "2677" "302.7" "7.17" "63.80" "19" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087" "23064" "ENSG00000107290" "SETX" "A2A396; B2RPB2; B5ME16; C9JQ10; hsa:23064; O75120; Q3KQX4; Q5JUJ1; Q68DW5; Q6AZD7; Q7Z333; Q7Z3J6; Q8WX33; Q9H9D1; Q9NVP9" "" "Interactome of polycomb repressive complex 2 (PRC2)" "1" "0" "1.038" "1.057" "1.068" "1.023" "1.028" "0.981" "1.087" "1.023" "1.019" "1464.4" "1520.6" "1548.0" "1564.2" "1498.6" "1504.9" "1436.3" "1592.5" "1498.4" "1491.5" "" "" "" "" "" "" "" "" "" "" "1176.2" "1097.2" "1229.6" "1048.0" "1036.4" "1129.1" "1005.6" "1163.0" "1498.4" "1212.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765443992663171126" "False" "High" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "0.000" "False" "64.113" "15" "13" "18" "8" "772" "87.6" "8.41" "67.25" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "" "miRNA regulation of DNA damage response; DNA damage response" "2" "1" "1.026" "1.022" "1.004" "0.965" "0.972" "0.956" "1.010" "1.007" "0.983" "1318.7" "1353.3" "1348.2" "1323.7" "1272.7" "1282.2" "1260.4" "1331.9" "1328.4" "1296.3" "" "" "" "" "" "" "" "" "" "" "1059.2" "976.5" "1070.9" "886.9" "880.2" "962.0" "882.5" "972.7" "1328.4" "1054.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9164959202025983104" "False" "High" "IsMasterProtein" "Q9BSJ2" "Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2" "0.000" "False" "64.052" "21" "16" "18" "16" "902" "102.5" "6.84" "56.01" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf04130, Pf17681" "10844" "ENSG00000130640" "TUBGCP2" "B4DM18; B7ZKL8; F5H4E0; F5H4L0; hsa:10844; O43632; Q5VWX7; Q9BSJ2" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "0.994" "0.977" "1.110" "0.985" "0.992" "0.895" "0.992" "0.977" "1.017" "1237.4" "1229.9" "1208.9" "1373.6" "1219.2" "1227.1" "1107.8" "1227.4" "1208.5" "1258.9" "" "" "" "" "" "" "" "" "" "" "993.9" "887.5" "960.3" "920.3" "843.2" "920.7" "775.6" "896.4" "1208.5" "1023.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5768546020460865093" "False" "High" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "0.000" "False" "64.047" "36" "9" "15" "9" "346" "39.2" "5.50" "55.47" "9" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "15" "0" "1.086" "1.049" "1.031" "1.048" "1.030" "0.998" "1.013" "1.024" "1.040" "1058.3" "1149.8" "1110.2" "1091.6" "1108.9" "1090.2" "1056.2" "1071.6" "1083.4" "1100.6" "" "" "" "" "" "" "" "" "" "" "850.0" "829.7" "881.8" "731.4" "766.9" "817.9" "739.5" "782.6" "1083.4" "895.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8735053905858643513" "False" "High" "IsMasterProtein" "Q16401" "26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3" "0.000" "False" "64.028" "32" "15" "19" "15" "504" "56.2" "5.48" "66.58" "15" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf10508" "5711" "ENSG00000095261" "PSMD5" "B4DZM8; hsa:5711; Q15045; Q16401; Q4VXG8" "ER-Phagosome pathway; Separation of Sister Chromatids; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "61" "0" "0.994" "0.987" "1.007" "0.965" "0.968" "0.943" "0.959" "0.952" "0.980" "1471.3" "1461.7" "1451.9" "1480.9" "1420.5" "1423.5" "1387.7" "1410.6" "1399.9" "1442.2" "" "" "" "" "" "" "" "" "" "" "1181.7" "1054.8" "1153.3" "992.2" "982.4" "1068.0" "971.6" "1030.2" "1399.9" "1172.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518810540954697302" "False" "High" "IsMasterProtein" "Q8TAT6" "Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3" "0.000" "False" "63.942" "22" "13" "19" "13" "608" "68.1" "6.38" "59.45" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05020, Pf05021, Pf11543" "55666" "ENSG00000182446" "NPLOC4" "hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229" "KEAP1-NFE2L2 pathway; Neddylation; Translesion Synthesis by POLH" "" "3" "0" "1.001" "1.037" "1.018" "0.962" "0.977" "0.996" "1.041" "0.990" "0.995" "1978.2" "1981.1" "2051.1" "2014.4" "1903.1" "1932.5" "1970.5" "2059.9" "1958.2" "1968.0" "" "" "" "" "" "" "" "" "" "" "1588.9" "1429.5" "1629.3" "1349.6" "1316.2" "1449.9" "1379.6" "1504.3" "1958.2" "1600.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084161266970488512" "False" "High" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "0.000" "False" "63.926" "24" "11" "21" "11" "551" "60.2" "5.68" "74.20" "11" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Transcriptional regulation of white adipocyte differentiation; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Selenium metabolism and selenoproteins; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 15q11q13 copy number variation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "101" "0" "1.078" "1.042" "1.082" "1.133" "1.008" "1.092" "1.125" "1.073" "1.094" "981.5" "1058.3" "1022.4" "1061.6" "1112.5" "988.9" "1072.3" "1103.9" "1053.4" "1073.7" "" "" "" "" "" "" "" "" "" "" "788.3" "763.7" "812.1" "711.3" "769.4" "741.9" "750.7" "806.1" "1053.4" "873.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4078763853778873139" "False" "High" "IsMasterProtein" "O95816" "BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1" "0.000" "False" "63.910" "51" "11" "20" "11" "211" "23.8" "6.70" "61.30" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "9532" "ENSG00000112208" "BAG2" "B4DXE2; hsa:9532; O95816; Q08AS9; Q6FID0" "Regulation of HSF1-mediated heat shock response" "Pleural mesothelioma" "2" "0" "1.049" "1.024" "1.038" "1.016" "1.065" "1.092" "1.079" "1.099" "1.036" "3086.3" "3236.9" "3159.9" "3204.7" "3134.8" "3286.9" "3370.0" "3329.3" "3390.5" "3198.4" "" "" "" "" "" "" "" "" "" "" "2478.9" "2335.6" "2510.0" "2147.2" "2168.0" "2466.1" "2359.5" "2431.4" "3390.5" "2601.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3208052669097016746" "False" "High" "IsMasterProtein" "P51608" "Methyl-CpG-binding protein 2 OS=Homo sapiens OX=9606 GN=MECP2 PE=1 SV=1" "0.000" "False" "63.829" "22" "9" "13" "9" "486" "52.4" "9.95" "48.19" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429" "4204" "ENSG00000169057" "MECP2" "hsa:4204; O15233; P51608; Q6QHH9; Q7Z384" "" "Ectoderm differentiation; MECP2 and associated Rett syndrome; Lung fibrosis; Rett syndrome; Transcription co-factors SKI and SKIL protein partners; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Neurogenesis regulation in the olfactory epithelium; ADHD and autism (ASD) linked metabolic pathways and SNP; Sudden infant death syndrome (SIDS) susceptibility pathways" "10" "0" "1.033" "0.964" "1.051" "1.055" "1.007" "1.005" "1.021" "1.045" "1.024" "1280.3" "1322.0" "1234.7" "1346.2" "1350.2" "1288.7" "1286.9" "1306.9" "1337.5" "1310.8" "" "" "" "" "" "" "" "" "" "" "1028.3" "953.9" "980.8" "901.9" "933.8" "966.9" "901.0" "954.4" "1337.5" "1066.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-852377223734167343" "False" "High" "IsMasterProtein" "Q4G176" "Malonate--CoA ligase ACSF3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF3 PE=1 SV=3" "0.000" "False" "63.749" "23" "13" "22" "12" "576" "64.1" "8.37" "78.60" "13" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00501, Pf13193" "197322" "ENSG00000176715" "ACSF3" "A8K4J8; C9JQL6; hsa:197322; Q4G176; Q6INA0; Q8N2F7" "Synthesis of very long-chain fatty acyl-CoAs" "" "1" "0" "1.055" "1.025" "1.146" "1.138" "0.969" "1.107" "1.051" "1.074" "1.049" "1580.4" "1667.7" "1619.9" "1811.2" "1797.7" "1530.8" "1748.7" "1661.3" "1698.1" "1658.5" "" "" "" "" "" "" "" "" "" "" "1269.4" "1203.4" "1286.8" "1213.5" "1243.3" "1148.5" "1224.4" "1213.2" "1698.1" "1348.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1252831994268086785" "False" "High" "IsMasterProtein" "O00268" "Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2" "0.000" "False" "63.732" "14" "12" "13" "11" "1085" "110.0" "9.94" "46.25" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6874" "ENSG00000130699" "TAF4" "A6NGD9; hsa:6874; O00268; Q5TBP6; Q99721; Q9BR40; Q9BX42" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "9" "1" "0.965" "0.948" "0.952" "0.986" "0.910" "0.930" "0.998" "0.960" "0.942" "663.7" "640.5" "628.8" "632.0" "654.5" "603.7" "617.4" "662.3" "637.1" "625.3" "" "" "" "" "" "" "" "" "" "" "533.1" "462.1" "499.5" "423.5" "452.6" "452.9" "432.2" "483.7" "637.1" "508.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157210626844435621" "False" "High" "IsMasterProtein" "Q8IUI4" "Putative protein SNX29P2 OS=Homo sapiens OX=9606 GN=SNX29P2 PE=5 SV=2" "0.000" "False" "63.694" "49" "9" "17" "6" "249" "27.2" "4.94" "58.96" "9" "" "" "" "" "" "" "SNX29P2" "Q8IUI4" "" "" "0" "0" "1.026" "1.031" "1.004" "0.950" "0.941" "0.875" "0.941" "0.921" "0.959" "1407.3" "1443.3" "1450.4" "1413.3" "1337.1" "1323.8" "1230.9" "1324.4" "1296.4" "1349.1" "" "" "" "" "" "" "" "" "" "" "1130.3" "1041.5" "1152.1" "946.9" "924.7" "993.2" "861.8" "967.2" "1296.4" "1097.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3092682979585279254" "False" "High" "IsMasterProtein" "Q96BP3" "Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1" "0.000" "False" "63.684" "28" "15" "16" "15" "646" "73.5" "7.15" "51.68" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160, Pf00400" "23398" "ENSG00000113593" "PPWD1" "B4DWR9; hsa:23398; Q15002; Q7KZ89; Q96BP3" "mRNA Splicing - Major Pathway" "" "1" "0" "1.002" "1.072" "1.021" "1.087" "1.035" "1.017" "1.011" "1.060" "1.060" "1099.8" "1102.2" "1179.4" "1122.7" "1195.8" "1138.6" "1118.9" "1111.4" "1165.8" "1165.9" "" "" "" "" "" "" "" "" "" "" "883.3" "795.3" "936.8" "752.2" "827.0" "854.3" "783.4" "811.7" "1165.8" "948.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2580326738670543746" "False" "High" "IsMasterProtein" "O60341" "Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2" "0.000" "False" "63.668" "15" "13" "20" "13" "852" "92.8" "6.52" "66.69" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01593, Pf04433" "23028" "ENSG00000004487" "KDM1A" "A8MWP9; hsa:23028; O60341; Q5TH94; Q5TH95; Q86VT7; Q8IXK4; Q8NDP6; Q8TAZ3; Q96AW4" "Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "Androgen receptor signaling pathway; Effect of progerin on genes involved in progeria; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Neurogenesis regulation in the olfactory epithelium" "14" "0" "1.033" "1.019" "1.025" "1.042" "1.010" "0.989" "1.061" "1.017" "0.993" "1679.8" "1734.6" "1712.1" "1721.8" "1750.4" "1696.6" "1661.0" "1781.6" "1708.5" "1667.4" "" "" "" "" "" "" "" "" "" "" "1349.2" "1251.6" "1359.9" "1153.6" "1210.6" "1272.9" "1163.0" "1301.1" "1708.5" "1356.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755202633810832906" "False" "High" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "0.000" "False" "63.632" "17" "11" "12" "11" "747" "86.1" "6.62" "48.34" "11" "" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "Synthesis of PIPs at the early endosome membrane" "" "1" "0" "0.993" "0.994" "0.978" "0.980" "0.953" "0.995" "0.941" "1.039" "0.960" "787.8" "782.0" "783.2" "770.1" "771.6" "750.9" "783.5" "741.2" "818.3" "756.0" "" "" "" "" "" "" "" "" "" "" "632.7" "564.3" "622.1" "515.9" "533.7" "563.4" "548.6" "541.3" "818.3" "614.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530888468156294697" "False" "High" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "0.000" "False" "63.628" "20" "10" "15" "10" "588" "68.0" "7.33" "49.99" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.087" "1.056" "1.053" "1.095" "1.042" "1.105" "1.074" "1.113" "1.074" "1218.6" "1325.2" "1286.9" "1283.3" "1334.4" "1269.9" "1346.7" "1309.1" "1356.1" "1308.5" "" "" "" "" "" "" "" "" "" "" "978.8" "956.2" "1022.2" "859.8" "922.9" "952.8" "942.9" "956.0" "1356.1" "1064.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4414098033661647234" "False" "High" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "0.000" "False" "63.620" "31" "10" "24" "10" "359" "39.6" "7.17" "66.54" "10" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin activation and detoxification" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "3" "0" "1.071" "1.009" "0.991" "1.105" "0.889" "1.169" "1.075" "1.311" "1.060" "1170.0" "1252.8" "1180.5" "1159.3" "1292.6" "1040.7" "1367.2" "1258.0" "1533.4" "1239.7" "" "" "" "" "" "" "" "" "" "" "939.7" "904.0" "937.7" "776.8" "894.0" "780.8" "957.2" "918.7" "1533.4" "1008.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2614245215378921803" "False" "High" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "0.000" "False" "63.560" "21" "7" "14" "5" "362" "41.4" "9.28" "53.32" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "HATs acetylate histones" "Pathways affected in adenoid cystic carcinoma" "2" "2" "0.972" "0.993" "0.875" "0.914" "0.925" "0.857" "0.911" "0.972" "0.907" "2496.4" "2427.5" "2480.2" "2183.9" "2280.7" "2310.2" "2140.6" "2274.3" "2426.4" "2264.7" "" "" "" "" "" "" "" "" "" "" "2005.1" "1751.6" "1970.1" "1463.2" "1577.3" "1733.3" "1498.7" "1660.9" "2426.4" "1841.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7186431258293956911" "False" "High" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "0.000" "False" "63.548" "58" "8" "23" "8" "148" "17.2" "9.60" "69.34" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "" "2" "0" "0.988" "1.048" "0.917" "0.991" "1.046" "0.903" "0.916" "0.974" "0.960" "2333.1" "2305.7" "2446.0" "2138.4" "2310.9" "2441.3" "2107.0" "2136.8" "2273.3" "2240.8" "" "" "" "" "" "" "" "" "" "" "1873.9" "1663.7" "1942.9" "1432.8" "1598.2" "1831.7" "1475.2" "1560.5" "2273.3" "1822.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8329541297808121166" "False" "High" "IsMasterProtein" "P49848" "Transcription initiation factor TFIID subunit 6 OS=Homo sapiens OX=9606 GN=TAF6 PE=1 SV=1" "0.000" "False" "63.499" "18" "10" "12" "10" "677" "72.6" "8.60" "45.21" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "6878" "ENSG00000106290" "TAF6" "A4D2B2; A4D2B3; B4DT11; D6W5U2; hsa:6878; P49848; Q6AI29" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "Eukaryotic transcription initiation" "11" "0" "1.107" "1.116" "1.057" "1.058" "1.080" "0.976" "1.062" "1.188" "1.073" "866.7" "959.1" "967.7" "916.5" "916.7" "935.7" "845.9" "920.5" "1029.5" "929.6" "" "" "" "" "" "" "" "" "" "" "696.1" "692.1" "768.7" "614.0" "634.0" "702.0" "592.3" "672.3" "1029.5" "756.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1131809670189224217" "False" "High" "IsMasterProtein" "Q96EY7" "Small ribosomal subunit protein mS39 OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" "0.000" "False" "63.487" "22" "13" "19" "13" "689" "78.5" "6.42" "53.55" "13" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "translation activity;nucleic acid binding activity" "Pf13041, Pf13812" "55037" "ENSG00000132300" "PTCD3" "A6NHD2; D6W5M1; hsa:55037; Q597H0; Q658Y9; Q96EY7; Q9BUZ8; Q9NWL0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.064" "1.056" "1.027" "1.016" "0.939" "0.934" "1.072" "1.007" "0.990" "820.9" "873.4" "867.1" "842.8" "833.8" "770.6" "766.8" "879.7" "826.5" "812.6" "" "" "" "" "" "" "" "" "" "" "659.3" "630.2" "688.8" "564.7" "576.7" "578.2" "536.9" "642.4" "826.5" "660.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462981975688921114" "False" "High" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "0.000" "False" "63.465" "18" "13" "18" "13" "733" "81.7" "7.88" "54.36" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "0.987" "1.001" "0.978" "0.962" "0.972" "0.927" "1.003" "0.961" "0.963" "2231.5" "2201.8" "2233.8" "2181.9" "2146.4" "2168.8" "2069.1" "2238.4" "2144.2" "2149.2" "" "" "" "" "" "" "" "" "" "" "1792.3" "1588.8" "1774.4" "1461.9" "1484.5" "1627.2" "1448.7" "1634.7" "2144.2" "1747.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5448927889689110920" "False" "High" "IsMasterProtein" "Q16539" "Mitogen-activated protein kinase 14 OS=Homo sapiens OX=9606 GN=MAPK14 PE=1 SV=3" "0.000" "False" "63.373" "39" "11" "14" "10" "360" "41.3" "5.78" "53.53" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1432" "ENSG00000112062" "MAPK14" "A6ZJ92; A8K6P4; B0LPH0; B5TY32; hsa:1432; O60776; Q13083; Q14084; Q16539; Q8TDX0" "Neutrophil degranulation; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; Regulation of TP53 Activity through Phosphorylation; VEGFA-VEGFR2 Pathway; DSCAM interactions; RHO GTPases Activate NADPH Oxidases; Myogenesis; ERK/MAPK targets; Oxidative Stress Induced Senescence; ADP signalling through P2Y purinoceptor 1; p38MAPK events; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; KSRP (KHSRP) binds and destabilizes mRNA; Activation of the AP-1 family of transcription factors; Platelet sensitization by LDL; CD163 mediating an anti-inflammatory response" "Physiological and pathological hypertrophy of the heart; Angiogenesis; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Oxidative stress response; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Regulatory circuits of the STAT3 signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; Th17 cell differentiation pathway; GDNF signaling; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; IL-19 signaling pathway; Interferon type I signaling pathways; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Monoamine transport; Toll-like receptor signaling pathway" "92" "0" "1.048" "1.152" "1.005" "1.036" "1.099" "1.049" "1.072" "1.066" "1.126" "770.9" "808.1" "887.9" "774.9" "798.8" "847.1" "808.5" "826.0" "821.7" "868.1" "" "" "" "" "" "" "" "" "" "" "619.1" "583.1" "705.3" "519.2" "552.4" "635.6" "566.1" "603.3" "821.7" "706.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6238619609280539619" "False" "High" "IsMasterProtein" "Q9NZW5" "Protein PALS2 OS=Homo sapiens OX=9606 GN=PALS2 PE=1 SV=2" "0.000" "False" "63.300" "29" "15" "17" "15" "540" "61.1" "6.18" "56.30" "15" "cell organization and biogenesis" "plasma membrane;other membranes;other cell component" "" "Pf00595, Pf00625, Pf02828, Pf07653" "51678" "ENSG00000105926" "PALS2" "A4D157; hsa:51678; Q9H0E1; Q9NZW5" "" "" "0" "0" "0.952" "0.951" "0.926" "0.995" "0.949" "0.970" "0.986" "0.976" "0.985" "1881.9" "1792.1" "1789.0" "1743.1" "1873.2" "1785.0" "1825.8" "1854.9" "1837.5" "1853.8" "" "" "" "" "" "" "" "" "" "" "1511.6" "1293.1" "1421.0" "1167.9" "1295.5" "1339.3" "1278.3" "1354.7" "1837.5" "1507.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2091961222017639990" "False" "High" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "0.000" "False" "63.290" "25" "11" "17" "11" "557" "65.6" "6.64" "61.75" "11" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "mRNA Splicing - Major Pathway" "" "1" "0" "0.968" "1.030" "1.092" "1.071" "1.029" "1.076" "0.986" "1.020" "1.012" "977.7" "946.7" "1007.3" "1067.3" "1047.1" "1005.6" "1051.8" "964.2" "996.9" "989.7" "" "" "" "" "" "" "" "" "" "" "785.3" "683.1" "800.1" "715.1" "724.2" "754.5" "736.4" "704.2" "996.9" "804.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6612546022737726869" "False" "High" "IsMasterProtein" "P80303" "Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3" "0.000" "False" "63.280" "39" "14" "20" "14" "420" "50.2" "5.12" "53.40" "14" "signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13499" "4925" "ENSG00000070081" "NUCB2" "A8K642; D3DQX5; hsa:4925; P80303; Q8NFT5; V9HW75" "" "" "0" "0" "0.929" "0.923" "1.017" "1.011" "1.087" "1.101" "1.087" "1.142" "1.033" "1080.0" "1003.7" "996.3" "1098.1" "1091.8" "1174.4" "1188.6" "1174.0" "1233.6" "1115.2" "" "" "" "" "" "" "" "" "" "" "867.4" "724.2" "791.4" "735.7" "755.1" "881.1" "832.2" "857.4" "1233.6" "906.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-525798378457225330" "False" "High" "IsMasterProtein" "P0CG39" "POTE ankyrin domain family member J OS=Homo sapiens OX=9606 GN=POTEJ PE=1 SV=1" "0.000" "False" "63.279" "6" "6" "142" "1" "1038" "117.3" "5.97" "406.39" "6" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022, Pf12796, Pf14915" "653781" "ENSG00000222038" "POTEJ" "hsa:653781; P0CG39" "" "" "0" "0" "0.993" "1.056" "0.994" "1.225" "1.286" "1.203" "1.245" "1.244" "1.103" "260.9" "259.0" "275.6" "259.4" "319.7" "335.5" "313.8" "324.9" "324.5" "287.9" "" "" "" "" "" "" "" "" "" "" "209.6" "186.9" "218.9" "173.8" "221.1" "251.7" "219.7" "237.3" "324.5" "234.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4690988044632206279" "False" "High" "IsMasterProtein" "Q16719" "Kynureninase OS=Homo sapiens OX=9606 GN=KYNU PE=1 SV=1" "0.000" "False" "63.234" "27" "11" "19" "11" "465" "52.3" "7.03" "61.07" "11" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "8942" "ENSG00000115919" "KYNU" "B2RCZ5; D3DP79; hsa:8942; Q16719; Q6I9T2; Q9BVW3" "Tryptophan catabolism" "Selenium micronutrient network; NAD biosynthesis II (from tryptophan); Tryptophan metabolism" "4" "0" "0.942" "0.981" "0.929" "0.987" "0.999" "0.977" "0.979" "0.940" "0.955" "2182.2" "2056.6" "2140.6" "2027.0" "2152.9" "2180.0" "2132.5" "2136.8" "2051.4" "2084.5" "" "" "" "" "" "" "" "" "" "" "1752.7" "1484.0" "1700.3" "1358.1" "1489.0" "1635.6" "1493.0" "1560.5" "2051.4" "1695.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5978569898189539548" "False" "High" "IsMasterProtein" "O75694" "Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1" "0.000" "False" "63.221" "11" "12" "14" "12" "1391" "155.1" "6.16" "55.38" "12" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf08801" "9631" "ENSG00000113569" "NUP155" "hsa:9631; O75694; Q9UBE9; Q9UFL5" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "1.053" "0.964" "1.029" "1.092" "1.071" "1.057" "1.149" "1.076" "1.049" "876.5" "923.4" "845.2" "902.2" "957.5" "939.0" "926.3" "1007.2" "943.5" "919.8" "" "" "" "" "" "" "" "" "" "" "704.0" "666.3" "671.4" "604.5" "662.2" "704.5" "648.6" "735.6" "943.5" "748.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6970631393786121187" "False" "High" "IsMasterProtein" "Q8WU79" "Stromal membrane-associated protein 2 OS=Homo sapiens OX=9606 GN=SMAP2 PE=1 SV=1" "0.000" "False" "63.090" "26" "12" "19" "11" "429" "46.8" "8.87" "66.96" "12" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "64744" "ENSG00000084070" "SMAP2" "B2R7T1; B7Z5B5; B7Z8V2; D3DPV2; hsa:64744; Q5QPL2; Q8WU79; Q96C93; Q9NST2; Q9UJL8" "" "" "0" "0" "1.008" "1.003" "1.014" "1.012" "1.005" "0.977" "1.024" "1.042" "1.030" "1585.3" "1597.8" "1589.3" "1607.2" "1603.7" "1593.5" "1548.8" "1622.9" "1652.3" "1632.9" "" "" "" "" "" "" "" "" "" "" "1273.3" "1152.9" "1262.4" "1076.8" "1109.1" "1195.5" "1084.4" "1185.2" "1652.3" "1327.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9099415838211122916" "False" "High" "IsMasterProtein" "P33981" "Dual specificity protein kinase TTK OS=Homo sapiens OX=9606 GN=TTK PE=1 SV=2" "0.000" "False" "63.071" "16" "14" "15" "14" "857" "97.0" "8.16" "52.19" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7272" "ENSG00000112742" "TTK" "A8K8U5; B2RDW2; E1P543; hsa:7272; P33981; Q15272; Q5TCS0; Q9BW51; Q9NTM0" "" "Cell cycle; Retinoblastoma gene in cancer" "2" "0" "0.957" "0.938" "0.988" "0.977" "0.922" "0.907" "0.925" "0.920" "0.964" "1478.9" "1415.5" "1386.6" "1461.7" "1445.5" "1363.4" "1341.1" "1368.3" "1360.5" "1426.0" "" "" "" "" "" "" "" "" "" "" "1187.8" "1021.4" "1101.5" "979.3" "999.7" "1023.0" "939.0" "999.3" "1360.5" "1159.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059296943260836861" "False" "High" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "0.000" "False" "63.045" "39" "7" "18" "5" "201" "23.0" "8.29" "65.70" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "" "3" "0" "0.924" "0.887" "0.925" "0.946" "0.883" "0.979" "1.011" "0.988" "0.917" "1180.2" "1090.1" "1046.4" "1092.3" "1116.2" "1041.8" "1155.1" "1193.8" "1166.0" "1082.6" "" "" "" "" "" "" "" "" "" "" "948.0" "786.6" "831.2" "731.8" "772.0" "781.6" "808.7" "871.8" "1166.0" "880.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6562177240292846235" "False" "High" "IsMasterProtein" "Q99490" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=AGAP2 PE=1 SV=2" "0.000" "False" "62.922" "11" "11" "14" "11" "1192" "124.6" "9.89" "51.15" "11" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf00071, Pf01412" "116986" "ENSG00000135439" "AGAP2" "A8K9F7; hsa:116986; O00578; Q548E0; Q8IWU3; Q99490" "Netrin-1 signaling" "Prolactin signaling pathway; Fragile X syndrome; Netrin-UNC5B signaling pathway; 15q25 copy number variation" "5" "0" "1.002" "0.962" "1.038" "0.984" "0.973" "0.959" "0.992" "0.981" "0.953" "1199.4" "1201.4" "1153.9" "1244.7" "1180.1" "1167.3" "1150.3" "1189.9" "1177.2" "1143.4" "" "" "" "" "" "" "" "" "" "" "963.4" "866.9" "916.6" "834.0" "816.1" "875.8" "805.3" "869.0" "1177.2" "929.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9065508386869284325" "False" "High" "IsMasterProtein" "Q9Y2L5" "Trafficking protein particle complex subunit 8 OS=Homo sapiens OX=9606 GN=TRAPPC8 PE=1 SV=2" "0.000" "False" "62.914" "10" "15" "18" "15" "1435" "160.9" "6.87" "61.07" "15" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf12739" "22878" "ENSG00000153339" "TRAPPC8" "A0JP15; B3KME5; hsa:22878; Q9H0L2; Q9Y2L5" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.993" "0.976" "1.029" "0.985" "1.015" "0.960" "0.955" "0.948" "1.002" "2037.1" "2022.9" "1987.5" "2096.6" "2007.5" "2066.7" "1955.2" "1945.9" "1930.9" "2040.9" "" "" "" "" "" "" "" "" "" "" "1636.2" "1459.7" "1578.8" "1404.7" "1388.4" "1550.6" "1369.0" "1421.1" "1930.9" "1659.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3953719107085229180" "False" "High" "IsMasterProtein" "Q9Y6K9" "NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2" "0.000" "False" "62.731" "26" "11" "12" "11" "419" "48.2" "5.71" "44.61" "11" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf11577, Pf16516, Pf18414" "8517" "ENSG00000269335" "IKBKG" "hsa:8517; Q7LBY6; Q7Z7F1; Q9Y6K9" "Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; PKR-mediated signaling; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins" "Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "76" "0" "1.115" "0.997" "1.122" "1.096" "1.015" "1.073" "1.067" "1.172" "1.073" "1187.0" "1323.5" "1183.0" "1332.0" "1301.2" "1205.2" "1273.8" "1267.0" "1391.1" "1273.2" "" "" "" "" "" "" "" "" "" "" "953.4" "955.0" "939.7" "892.5" "899.9" "904.3" "891.8" "925.3" "1391.1" "1035.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5434950316255047491" "False" "High" "IsMasterProtein" "P42224" "Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens OX=9606 GN=STAT1 PE=1 SV=2" "0.000" "False" "62.721" "22" "14" "18" "14" "750" "87.3" "6.05" "54.55" "14" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12162, Pf21354" "6772" "ENSG00000115415" "STAT1" "A8K989; B2RCA0; D2KFR8; D3DPI7; hsa:6772; P42224; Q53S88; Q53XW4; Q68D00; Q9UDL5" "PKR-mediated signaling; Interleukin-4 and Interleukin-13 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Regulation of RUNX2 expression and activity; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Growth hormone receptor signaling; Interleukin-6 signaling; Interferon alpha/beta signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; NOTCH3 Intracellular Domain Regulates Transcription; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-27 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Allograft rejection; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Kit receptor signaling pathway; IL6 signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Immune response to tuberculosis; Ebola virus infection in host; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Tryptophan metabolism; Hepatitis B infection; Endochondral ossification; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; CCL18 signaling pathway; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; 2q13 copy number variation syndrome; TROP2 regulatory signaling; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Type II interferon signaling; Toll-like receptor signaling pathway" "83" "0" "1.018" "1.060" "1.072" "1.076" "1.033" "1.058" "1.051" "1.027" "1.064" "982.8" "1000.5" "1041.4" "1053.4" "1057.3" "1015.3" "1040.0" "1032.5" "1009.6" "1045.8" "" "" "" "" "" "" "" "" "" "" "789.4" "722.0" "827.2" "705.8" "731.2" "761.8" "728.1" "754.1" "1009.6" "850.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2637590011477773491" "False" "High" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "0.000" "False" "62.698" "17" "13" "17" "13" "744" "82.5" "6.95" "56.40" "13" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; P46459; Q8N6D7; Q9UKZ2" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Vasopressin-regulated water reabsorption" "9" "0" "0.933" "0.990" "1.039" "1.018" "0.948" "1.196" "0.917" "1.012" "1.028" "1202.8" "1122.3" "1190.7" "1249.6" "1224.9" "1140.1" "1438.7" "1102.5" "1216.9" "1236.9" "" "" "" "" "" "" "" "" "" "" "966.1" "809.8" "945.8" "837.3" "847.2" "855.4" "1007.3" "805.2" "1216.9" "1005.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3075207303668690710" "False" "High" "IsMasterProtein" "P37198" "Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3" "0.000" "False" "62.688" "15" "6" "14" "6" "522" "53.2" "5.31" "64.86" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05064" "23636" "ENSG00000213024" "NUP62" "B3KWU5; hsa:23636; P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1" "Nuclear Pore Complex (NPC) Disassembly; HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "7q11.23 copy number variation syndrome" "30" "0" "1.006" "0.954" "1.015" "1.030" "0.975" "0.977" "0.987" "0.991" "0.980" "909.5" "915.2" "867.7" "923.0" "936.4" "886.6" "888.7" "897.7" "901.5" "891.2" "" "" "" "" "" "" "" "" "" "" "730.5" "660.3" "689.3" "618.4" "647.6" "665.2" "622.2" "655.6" "901.5" "724.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714438533049162384" "False" "High" "IsMasterProtein" "O94953" "Lysine-specific demethylase 4B OS=Homo sapiens OX=9606 GN=KDM4B PE=1 SV=4" "0.000" "False" "62.671" "12" "10" "13" "10" "1096" "121.8" "7.09" "47.67" "10" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "23030" "ENSG00000127663" "KDM4B" "B9EGN8; D6W631; hsa:23030; O75274; O94953; Q6P3R5; Q9P1V1; Q9UF40" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones" "" "3" "0" "1.091" "1.002" "1.065" "1.110" "1.062" "0.993" "1.017" "1.066" "1.104" "517.3" "564.3" "518.2" "550.7" "574.1" "549.2" "513.5" "526.2" "551.6" "571.2" "" "" "" "" "" "" "" "" "" "" "415.4" "407.2" "411.6" "369.0" "397.1" "412.1" "359.6" "384.3" "551.6" "464.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2447510198658431817" "False" "High" "IsMasterProtein" "Q9H910" "Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1" "0.000" "False" "62.636" "66" "9" "19" "9" "190" "20.1" "9.26" "72.39" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf17054" "90861" "ENSG00000206053" "JPT2" "B1AJY2; B4DLH4; hsa:90861; Q6EIC7; Q9H910" "" "" "0" "0" "0.994" "0.961" "1.022" "0.998" "1.019" "1.058" "1.026" "1.039" "0.989" "1286.6" "1278.8" "1236.1" "1314.6" "1284.5" "1311.1" "1360.9" "1320.2" "1337.4" "1272.8" "" "" "" "" "" "" "" "" "" "" "1033.4" "922.8" "981.8" "880.8" "888.4" "983.7" "952.8" "964.1" "1337.4" "1035.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3175822401937946454" "False" "High" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "0.000" "False" "62.630" "22" "9" "17" "9" "572" "61.2" "6.67" "65.36" "9" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "" "Integrin-mediated cell adhesion; Focal adhesion" "2" "0" "1.008" "0.992" "1.097" "1.085" "1.102" "1.167" "1.121" "1.083" "1.069" "1094.7" "1103.3" "1086.0" "1200.9" "1187.2" "1206.1" "1277.6" "1227.5" "1185.2" "1170.3" "" "" "" "" "" "" "" "" "" "" "879.3" "796.1" "862.7" "804.6" "821.1" "904.9" "894.5" "896.4" "1185.2" "951.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104369569183716546" "False" "High" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "0.000" "False" "62.607" "16" "10" "14" "10" "607" "68.6" "5.80" "49.82" "10" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "1.022" "0.977" "0.994" "0.977" "0.972" "1.030" "1.027" "1.051" "1.022" "791.1" "808.8" "772.8" "786.6" "773.2" "769.1" "815.0" "812.7" "831.4" "808.2" "" "" "" "" "" "" "" "" "" "" "635.4" "583.6" "613.9" "527.0" "534.8" "577.0" "570.6" "593.5" "831.4" "657.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4697370261215889932" "False" "High" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "0.000" "False" "62.597" "40" "6" "14" "6" "198" "22.1" "5.30" "61.70" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253, Pf21023" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "0.982" "1.012" "0.994" "0.960" "1.038" "1.075" "1.040" "1.020" "0.989" "1695.5" "1664.5" "1715.3" "1684.5" "1627.0" "1759.9" "1822.9" "1763.1" "1729.3" "1677.4" "" "" "" "" "" "" "" "" "" "" "1361.8" "1201.0" "1362.5" "1128.6" "1125.3" "1320.4" "1276.3" "1287.6" "1729.3" "1364.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532813342924820659" "False" "High" "IsMasterProtein" "Q9Y383" "Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2" "0.000" "False" "62.573" "30" "11" "15" "7" "392" "46.5" "10.01" "55.49" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "51631" "ENSG00000146963" "LUC7L2" "B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383" "" "" "0" "2" "1.065" "1.194" "1.119" "1.072" "1.148" "1.170" "1.310" "1.353" "1.171" "1488.9" "1585.1" "1777.4" "1666.1" "1595.3" "1708.9" "1742.4" "1951.1" "2015.0" "1743.8" "" "" "" "" "" "" "" "" "" "" "1195.8" "1143.7" "1411.9" "1116.3" "1103.3" "1282.2" "1219.9" "1424.9" "2015.0" "1418.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246556582121742605" "False" "High" "IsMasterProtein" "Q9P253" "Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2" "0.000" "False" "62.541" "16" "13" "16" "13" "973" "110.1" "6.07" "54.94" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05131" "57617" "ENSG00000104142" "VPS18" "hsa:57617; Q8TCG0; Q96DI3; Q9H268; Q9P253" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "3" "0" "1.074" "1.009" "1.064" "1.044" "1.003" "1.055" "1.028" "1.064" "1.083" "975.9" "1048.3" "984.6" "1038.0" "1018.5" "979.3" "1029.4" "1003.5" "1038.7" "1057.1" "" "" "" "" "" "" "" "" "" "" "783.8" "756.4" "782.1" "695.4" "704.4" "734.7" "720.8" "732.9" "1038.7" "859.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5082096534662267594" "False" "High" "IsMasterProtein" "Q9C026" "E3 ubiquitin-protein ligase TRIM9 OS=Homo sapiens OX=9606 GN=TRIM9 PE=1 SV=1" "0.000" "False" "62.397" "17" "11" "21" "11" "710" "79.1" "6.84" "63.02" "11" "protein metabolism;other metabolic processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00041, Pf00097, Pf00622, Pf00643" "114088" "ENSG00000100505" "TRIM9" "D3DSB7; D3DSB8; hsa:114088; Q92557; Q96D24; Q96NI4; Q9C025; Q9C026; Q9C027" "Antigen processing: Ubiquitination & Proteasome degradation" "Orexin receptor pathway" "2" "0" "1.000" "1.036" "1.036" "1.055" "0.989" "0.992" "0.958" "1.017" "1.043" "1017.8" "1017.5" "1054.5" "1054.7" "1074.1" "1006.7" "1009.1" "975.3" "1035.5" "1061.9" "" "" "" "" "" "" "" "" "" "" "817.5" "734.2" "837.6" "706.6" "742.9" "755.3" "706.6" "712.2" "1035.5" "863.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7727744455345483682" "False" "High" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "0.000" "False" "62.366" "36" "8" "15" "8" "293" "32.8" "7.50" "53.30" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985, Pf21266" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "0.995" "1.044" "1.092" "1.073" "1.033" "1.088" "1.076" "1.040" "1.031" "1008.6" "1004.0" "1053.2" "1101.5" "1082.7" "1041.5" "1097.7" "1085.0" "1048.7" "1040.0" "" "" "" "" "" "" "" "" "" "" "810.1" "724.4" "836.6" "738.0" "748.8" "781.4" "768.6" "792.4" "1048.7" "845.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167307694424558965" "False" "High" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "0.000" "False" "62.343" "38" "8" "18" "8" "258" "27.5" "6.05" "63.03" "8" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate pathway" "Pentose phosphate metabolism" "2" "0" "0.991" "0.986" "1.005" "0.994" "0.929" "0.941" "0.945" "0.919" "0.956" "2056.1" "2037.0" "2026.8" "2065.7" "2044.2" "1909.9" "1934.8" "1943.3" "1890.3" "1964.9" "" "" "" "" "" "" "" "" "" "" "1651.5" "1469.9" "1610.0" "1384.0" "1413.8" "1433.0" "1354.6" "1419.2" "1890.3" "1597.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1505271825198651647" "False" "High" "IsMasterProtein" "P41236" "Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2" "0.000" "False" "62.303" "34" "5" "10" "5" "205" "23.0" "4.74" "46.88" "5" "other metabolic processes;other biological processes" "" "enzyme regulator activity;other molecular function" "Pf04979" "5504" "ENSG00000184203" "PPP1R2" "hsa:5504; P41236" "" "" "0" "0" "1.084" "1.102" "1.159" "1.125" "1.083" "1.131" "1.044" "1.194" "1.165" "382.1" "414.2" "421.2" "442.9" "429.7" "413.7" "432.0" "398.8" "456.4" "444.9" "" "" "" "" "" "" "" "" "" "" "306.9" "298.9" "334.6" "296.8" "297.2" "310.4" "302.5" "291.2" "456.4" "361.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9199223731198630068" "False" "High" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "0.000" "False" "62.297" "53" "12" "22" "12" "227" "25.6" "9.16" "74.70" "12" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "Factors involved in megakaryocyte development and platelet production" "" "1" "0" "1.018" "1.009" "0.973" "0.947" "0.954" "0.924" "0.971" "0.972" "0.970" "2797.0" "2846.3" "2823.0" "2721.6" "2649.5" "2667.5" "2584.0" "2717.0" "2717.5" "2714.1" "" "" "" "" "" "" "" "" "" "" "2246.5" "2053.8" "2242.4" "1823.5" "1832.4" "2001.4" "1809.2" "1984.2" "2717.5" "2207.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010766793389346536" "False" "High" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "0.000" "False" "62.227" "40" "6" "62" "6" "149" "16.8" "4.22" "189.28" "6" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "17" "0" "1.056" "1.062" "1.111" "1.189" "1.143" "1.181" "1.239" "1.162" "1.135" "2833.3" "2991.0" "3010.2" "3149.0" "3369.2" "3237.7" "3346.8" "3511.1" "3292.4" "3214.5" "" "" "" "" "" "" "" "" "" "" "2275.7" "2158.2" "2391.1" "2109.8" "2330.2" "2429.2" "2343.2" "2564.2" "3292.4" "2614.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700006474042265009" "False" "High" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "0.000" "False" "62.212" "18" "10" "18" "5" "585" "63.8" "9.04" "63.24" "10" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "4" "0.982" "0.999" "0.953" "1.008" "0.994" "0.954" "0.989" "1.030" "0.989" "1950.9" "1916.0" "1948.5" "1858.8" "1967.0" "1939.7" "1860.2" "1928.8" "2009.6" "1929.3" "" "" "" "" "" "" "" "" "" "" "1566.9" "1382.5" "1547.7" "1245.4" "1360.4" "1455.3" "1302.4" "1408.6" "2009.6" "1568.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980948205033410350" "False" "High" "IsMasterProtein" "Q8WXI9" "Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1" "0.000" "False" "62.124" "27" "12" "14" "11" "593" "65.2" "9.70" "50.27" "12" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "57459" "ENSG00000143614; ENSG00000261992" "GATAD2B" "D3DUZ2; hsa:57459; Q5VUR2; Q7LG68; Q8WXI9; Q9ULS0" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "" "6" "0" "1.031" "1.099" "1.064" "0.962" "1.009" "0.885" "1.094" "1.034" "1.023" "1008.0" "1039.6" "1107.7" "1072.5" "969.3" "1017.0" "891.8" "1103.0" "1042.6" "1031.1" "" "" "" "" "" "" "" "" "" "" "809.6" "750.1" "879.9" "718.6" "670.4" "763.0" "624.4" "805.5" "1042.6" "838.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8882666347281850930" "False" "High" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "0.000" "False" "62.073" "51" "12" "23" "10" "271" "31.5" "6.87" "72.88" "12" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "PI and PC transport between ER and Golgi membranes" "" "1" "1" "0.997" "1.031" "0.979" "0.966" "0.950" "0.944" "0.977" "0.951" "0.973" "1963.7" "1958.5" "2024.5" "1921.6" "1897.3" "1865.9" "1854.1" "1918.9" "1867.0" "1910.1" "" "" "" "" "" "" "" "" "" "" "1577.2" "1413.2" "1608.1" "1287.4" "1312.2" "1400.0" "1298.2" "1401.4" "1867.0" "1553.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5945011317712517661" "False" "High" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "0.000" "False" "62.043" "47" "7" "14" "7" "234" "25.9" "7.43" "59.32" "7" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "0.975" "0.999" "0.974" "1.167" "1.056" "1.113" "1.002" "0.994" "0.959" "404.8" "394.8" "404.4" "394.2" "472.3" "427.3" "450.6" "405.8" "402.6" "388.1" "" "" "" "" "" "" "" "" "" "" "325.1" "284.9" "321.2" "264.1" "326.7" "320.6" "315.5" "296.3" "402.6" "315.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254459010250463691" "False" "High" "IsMasterProtein" "Cont_Q3ZBD7" "Glucose-6-phosphate isomerase OS=Bos taurus OX=9913 GN=GPI PE=2 SV=4" "0.000" "True" "62.000" "18" "8" "23" "2" "557" "62.8" "7.71" "80.66" "8" "other metabolic processes;signal transduction" "non-structural extracellular;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "104995211; 109572099; 280808" "ENSBTAG00000006396" "GPI" "A0A6B0R509; A0A6P3HXC3; A0A6P5DB13; biu:109572099; bta:280808; F1MD19; O46595; Q3ZBD7" "TP53 Regulates Metabolic Genes; Neutrophil degranulation; Gluconeogenesis; Glycolysis" "Glycolysis and gluconeogenesis; Cori cycle" "6" "0" "0.925" "0.985" "0.920" "0.928" "0.972" "0.943" "0.938" "0.958" "1.012" "416.3" "385.1" "410.1" "383.1" "386.4" "404.6" "392.6" "390.5" "398.8" "421.3" "" "" "" "" "" "" "" "" "" "" "334.3" "277.9" "325.8" "256.7" "267.2" "303.6" "274.9" "285.2" "398.8" "342.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4417786093828078874" "False" "High" "IsMasterProtein" "Q9H1A4" "Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1" "0.000" "False" "61.935" "9" "14" "15" "14" "1944" "216.4" "6.30" "53.22" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12859, Pf18122, Pf20518, Pf21282" "64682" "ENSG00000153107" "ANAPC1" "hsa:64682; Q2M3H8; Q9BSE6; Q9H1A4; Q9H8D0" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle; 2q13 copy number variation syndrome" "20" "0" "1.037" "0.977" "1.037" "0.992" "1.003" "0.974" "1.086" "0.976" "1.015" "962.8" "998.8" "940.9" "998.7" "955.6" "966.0" "937.8" "1046.0" "939.6" "977.5" "" "" "" "" "" "" "" "" "" "" "773.3" "720.7" "747.4" "669.1" "660.9" "724.7" "656.6" "763.9" "939.6" "795.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006297447401564784" "False" "High" "IsMasterProtein" "Q96B23" "Protein ARK2N OS=Homo sapiens OX=9606 GN=ARK2N PE=1 SV=3" "0.000" "False" "61.895" "24" "7" "11" "7" "404" "43.4" "4.88" "41.17" "7" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15303" "147339" "ENSG00000152242" "ARK2N" "A8K123; A8KAB6; hsa:147339; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5; Q96B23" "" "" "0" "0" "1.053" "1.099" "1.038" "1.041" "1.078" "0.986" "1.096" "1.092" "1.033" "1094.5" "1152.1" "1202.6" "1136.0" "1139.3" "1179.9" "1079.4" "1199.4" "1195.2" "1130.8" "" "" "" "" "" "" "" "" "" "" "879.1" "831.3" "955.3" "761.1" "788.0" "885.3" "755.7" "875.9" "1195.2" "919.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957906910240928632" "False" "High" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "0.000" "False" "61.887" "19" "13" "16" "13" "750" "83.1" "6.93" "53.45" "13" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "Vitamin B12 metabolism; Amino acid metabolism" "6" "0" "1.019" "0.945" "0.945" "1.040" "0.977" "0.991" "1.003" "1.007" "0.945" "1100.6" "1120.9" "1040.1" "1040.5" "1144.1" "1075.0" "1091.1" "1104.4" "1108.5" "1039.8" "" "" "" "" "" "" "" "" "" "" "884.0" "808.8" "826.2" "697.1" "791.2" "806.5" "764.0" "806.5" "1108.5" "845.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1612491288449717862" "False" "High" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "0.000" "False" "61.860" "33" "9" "19" "9" "320" "35.3" "8.22" "78.33" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00043, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "5" "0" "1.005" "0.990" "1.085" "1.050" "1.015" "1.070" "0.990" "0.999" "1.026" "1666.9" "1674.7" "1650.8" "1808.2" "1749.8" "1692.4" "1783.5" "1650.4" "1664.9" "1709.5" "" "" "" "" "" "" "" "" "" "" "1338.8" "1208.4" "1311.2" "1211.5" "1210.2" "1269.8" "1248.7" "1205.3" "1664.9" "1390.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4054510205684443302" "False" "High" "IsMasterProtein" "Q9Y6X8" "Zinc fingers and homeoboxes protein 2 OS=Homo sapiens OX=9606 GN=ZHX2 PE=1 SV=1" "0.000" "False" "61.857" "20" "14" "18" "14" "837" "92.3" "6.86" "62.88" "14" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf18387" "22882" "ENSG00000178764" "ZHX2" "hsa:22882; Q9Y6X8" "" "" "0" "0" "1.004" "0.940" "0.991" "1.013" "0.960" "0.888" "0.946" "0.964" "0.988" "1477.2" "1483.4" "1389.0" "1464.4" "1496.9" "1417.5" "1311.9" "1397.8" "1424.3" "1458.7" "" "" "" "" "" "" "" "" "" "" "1186.4" "1070.4" "1103.3" "981.2" "1035.2" "1063.5" "918.5" "1020.8" "1424.3" "1186.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952075756115425488" "False" "High" "IsMasterProtein" "Cont_P34955" "Alpha-1-antiproteinase OS=Bos taurus OX=9913 GN=SERPINA1 PE=1 SV=1" "0.000" "True" "61.816" "21" "9" "22" "9" "416" "46.1" "6.52" "79.76" "9" "" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "109575576; 280699" "ENSBIXG00000014418; ENSBIXG00005018236; ENSBTAG00000018843" "SERPINA1" "A0A4W2DYT6; A0A6P5DQE7; biu:109575576; bta:280699; P34955; Q3SZS3" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER; COPII-mediated vesicle transport" "Complement and coagulation cascades; NRF2 pathway" "8" "0" "0.973" "0.883" "1.059" "0.919" "1.005" "1.479" "0.877" "0.914" "0.971" "3191.2" "3106.0" "2816.7" "3379.1" "2931.9" "3207.3" "4718.6" "2799.8" "2916.3" "3098.7" "" "" "" "" "" "" "" "" "" "" "2563.2" "2241.2" "2237.4" "2264.0" "2027.7" "2406.4" "3303.7" "2044.7" "2916.3" "2519.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7726317818688943966" "False" "High" "IsMasterProtein" "Q9NQC3" "Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2" "0.000" "False" "61.791" "11" "9" "11" "9" "1192" "129.9" "4.50" "45.28" "9" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02453" "57142" "ENSG00000115310" "RTN4" "O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9NQC3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6" "Axonal growth inhibition (RHOA activation)" "Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; 13q12.12 copy number variation" "7" "0" "1.020" "0.983" "1.029" "1.024" "0.953" "0.997" "1.003" "0.960" "0.983" "885.7" "903.1" "870.8" "911.8" "906.7" "843.7" "882.9" "888.2" "850.1" "870.7" "" "" "" "" "" "" "" "" "" "" "711.4" "651.6" "691.7" "610.9" "627.1" "633.0" "618.2" "648.7" "850.1" "708.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9162404171034655345" "False" "High" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "0.000" "False" "61.790" "15" "9" "14" "9" "722" "79.2" "6.80" "49.63" "9" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "Sialylation" "3" "0" "1.026" "1.018" "1.042" "1.071" "1.027" "1.104" "1.030" "1.075" "1.059" "917.2" "941.4" "933.9" "955.6" "982.7" "942.1" "1012.5" "944.5" "986.1" "971.2" "" "" "" "" "" "" "" "" "" "" "736.6" "679.3" "741.8" "640.2" "679.6" "706.8" "708.9" "689.8" "986.1" "789.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9215017324203505863" "False" "High" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "0.000" "False" "61.758" "11" "13" "16" "13" "1299" "150.0" "5.54" "56.76" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.068" "1.052" "1.140" "1.113" "1.075" "1.139" "1.115" "1.065" "1.067" "998.1" "1065.6" "1049.8" "1137.8" "1110.8" "1073.1" "1136.5" "1112.6" "1062.7" "1065.3" "" "" "" "" "" "" "" "" "" "" "801.6" "768.9" "833.9" "762.3" "768.2" "805.2" "795.7" "812.6" "1062.7" "866.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5029706333006790084" "False" "High" "IsMasterProtein" "Q5VT52" "Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1" "0.000" "False" "61.737" "11" "12" "16" "12" "1461" "155.9" "7.42" "55.26" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818" "23248" "ENSG00000163125" "RPRD2" "A8K6N8; B3KPT1; B4E2Q6; hsa:23248; O75048; Q5VT51; Q5VT52; Q5VT53; Q6MZL4; Q86XD2; Q9P0D7" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.058" "1.018" "1.058" "1.100" "1.062" "1.004" "1.104" "1.097" "1.051" "1224.6" "1295.6" "1246.4" "1295.4" "1346.6" "1300.4" "1229.7" "1351.5" "1343.7" "1287.7" "" "" "" "" "" "" "" "" "" "" "983.6" "934.9" "990.1" "867.9" "931.3" "975.6" "861.0" "987.0" "1343.7" "1047.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054050603788689952" "False" "High" "IsMasterProtein" "Q86YV0" "RAS protein activator like-3 OS=Homo sapiens OX=9606 GN=RASAL3 PE=1 SV=2" "0.000" "False" "61.734" "13" "12" "13" "12" "1011" "111.8" "8.75" "46.24" "12" "other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00616" "64926" "ENSG00000105122" "RASAL3" "hsa:64926; Q86YV0; Q8N2T9; Q9H735" "Regulation of RAS by GAPs" "Ras signaling" "2" "0" "1.107" "1.087" "1.178" "1.117" "1.017" "1.121" "1.203" "1.102" "1.125" "555.6" "615.0" "604.1" "654.4" "620.7" "565.0" "623.1" "668.4" "612.5" "625.0" "" "" "" "" "" "" "" "" "" "" "446.3" "443.8" "479.8" "438.4" "429.3" "423.9" "436.2" "488.2" "612.5" "508.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8786307772961790223" "False" "High" "IsMasterProtein" "Q6QNY1" "Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Homo sapiens OX=9606 GN=BLOC1S2 PE=1 SV=1" "0.000" "False" "61.657" "39" "5" "13" "5" "142" "16.0" "4.86" "50.70" "5" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf10046" "282991" "ENSG00000196072" "BLOC1S2" "B4DQV2; hsa:282991; Q5W040; Q6QNY1; Q8WUI8" "" "" "0" "0" "0.943" "0.968" "0.897" "0.859" "0.957" "0.920" "0.998" "0.955" "0.958" "1226.6" "1156.2" "1187.9" "1099.7" "1054.0" "1173.4" "1128.4" "1224.4" "1171.5" "1175.1" "" "" "" "" "" "" "" "" "" "" "985.2" "834.3" "943.6" "736.8" "729.0" "880.4" "790.0" "894.2" "1171.5" "955.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8289862670679680301" "False" "High" "IsMasterProtein" "Q96EK7" "Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Homo sapiens OX=9606 GN=FAM120B PE=1 SV=1" "0.000" "False" "61.596" "19" "12" "19" "12" "910" "103.7" "5.69" "52.85" "12" "signal transduction;other biological processes" "nucleus" "" "" "84498" "ENSG00000112584; ENSG00000275333" "FAM120B" "B4DL34; hsa:84498; Q86V68; Q96EK7; Q96JI9" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "" "2" "0" "1.000" "0.973" "1.073" "1.040" "0.999" "1.098" "1.082" "1.037" "1.016" "1131.9" "1131.8" "1101.2" "1214.6" "1177.4" "1130.5" "1242.7" "1224.5" "1173.6" "1150.2" "" "" "" "" "" "" "" "" "" "" "909.1" "816.7" "874.7" "813.8" "814.3" "848.2" "870.1" "894.2" "1173.6" "935.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6212598245542673461" "False" "High" "IsMasterProtein" "Q92879" "CUGBP Elav-like family member 1 OS=Homo sapiens OX=9606 GN=CELF1 PE=1 SV=2" "0.000" "False" "61.569" "19" "9" "20" "7" "486" "52.0" "8.46" "62.60" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10658" "ENSG00000149187" "CELF1" "B4E2U5; D3DQS0; F8W940; Q4LE52; Q92879; Q9NP83; Q9NR06" "" "Adipogenesis; mRNA processing" "2" "2" "0.996" "0.995" "1.072" "1.027" "1.003" "0.961" "1.003" "0.945" "1.059" "1813.1" "1805.8" "1804.6" "1943.1" "1861.8" "1819.2" "1742.3" "1818.2" "1712.6" "1920.1" "" "" "" "" "" "" "" "" "" "" "1456.3" "1303.0" "1433.4" "1301.9" "1287.6" "1364.9" "1219.9" "1327.8" "1712.6" "1561.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620722506811584939" "False" "High" "IsMasterProtein" "Q96GG9" "DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1" "0.000" "False" "61.468" "34" "9" "19" "8" "259" "30.1" "5.34" "67.54" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "54165" "ENSG00000043093" "DCUN1D1" "B2RB37; hsa:54165; Q7L3G9; Q8TEX7; Q96GG9; Q9H6M1; Q9HCT3" "Neddylation" "" "1" "1" "0.996" "1.002" "0.958" "1.005" "1.072" "0.973" "0.975" "0.949" "1.008" "2849.4" "2837.1" "2856.0" "2729.1" "2863.9" "3055.4" "2771.5" "2779.3" "2704.5" "2871.0" "" "" "" "" "" "" "" "" "" "" "2288.6" "2047.2" "2268.6" "1828.5" "1980.7" "2292.4" "1940.5" "2029.8" "2704.5" "2334.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8378095313839820512" "False" "High" "IsMasterProtein" "P15923" "Transcription factor E2-alpha OS=Homo sapiens OX=9606 GN=TCF3 PE=1 SV=1" "0.000" "False" "61.383" "11" "6" "9" "6" "654" "67.6" "6.47" "37.57" "6" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6929" "ENSG00000071564" "TCF3" "hsa:6929; P15883; P15923; Q14208; Q14635; Q14636; Q2TB39; Q2TB40; Q9UPI9" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis" "Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; lncRNA in canonical Wnt signaling and colorectal cancer; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "9" "0" "1.051" "1.013" "1.034" "1.051" "1.009" "0.989" "1.058" "1.048" "1.056" "1097.7" "1153.9" "1112.1" "1135.3" "1153.6" "1107.8" "1085.7" "1161.7" "1150.5" "1159.6" "" "" "" "" "" "" "" "" "" "" "881.6" "832.6" "883.4" "760.6" "797.9" "831.2" "760.1" "848.4" "1150.5" "943.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2325443013124673649" "False" "High" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "0.000" "False" "61.383" "25" "11" "16" "11" "501" "54.1" "6.24" "49.56" "11" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "1.007" "1.000" "1.055" "0.963" "0.980" "0.959" "0.935" "0.935" "0.997" "1569.1" "1580.3" "1569.0" "1655.6" "1511.8" "1538.3" "1504.1" "1467.6" "1466.5" "1564.2" "" "" "" "" "" "" "" "" "" "" "1260.3" "1140.3" "1246.3" "1109.3" "1045.6" "1154.2" "1053.1" "1071.8" "1466.5" "1272.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101901840121098087" "False" "High" "IsMasterProtein" "P52788" "Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2" "0.000" "False" "61.310" "34" "11" "20" "11" "366" "41.2" "5.02" "62.46" "11" "other metabolic processes" "cytosol" "other molecular function" "Pf01564, Pf17284, Pf17950" "6611" "ENSG00000102172" "SMS" "A6NHA7; A6NI34; B2R9M0; hsa:6611; O00544; P52788; Q9UQS1" "Metabolism of polyamines" "Methionine de novo and salvage pathway; Amino acid metabolism" "3" "0" "1.021" "1.007" "0.965" "1.036" "1.052" "1.013" "0.996" "0.986" "1.042" "1341.0" "1368.9" "1350.4" "1294.1" "1389.9" "1411.2" "1359.1" "1336.0" "1322.4" "1397.0" "" "" "" "" "" "" "" "" "" "" "1077.1" "987.8" "1072.6" "867.0" "961.3" "1058.8" "951.6" "975.7" "1322.4" "1136.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8599582728715422228" "False" "High" "IsMasterProtein" "Q01432" "AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1" "0.000" "False" "61.307" "19" "15" "16" "14" "767" "88.8" "6.98" "51.58" "15" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf19326" "272" "ENSG00000133805" "AMPD3" "A0AUX0; B7Z2S2; B7Z763; B7Z877; hsa:272; Q01432" "Neutrophil degranulation; Purine salvage" "" "2" "0" "0.959" "0.997" "1.050" "1.021" "1.028" "1.019" "1.016" "0.991" "1.029" "1141.0" "1094.6" "1138.0" "1197.5" "1165.1" "1172.5" "1162.1" "1159.6" "1130.4" "1173.8" "" "" "" "" "" "" "" "" "" "" "916.4" "789.9" "903.9" "802.3" "805.8" "879.7" "813.6" "846.9" "1130.4" "954.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-11749500110992675" "False" "High" "IsMasterProtein" "Q92995" "Ubiquitin carboxyl-terminal hydrolase 13 OS=Homo sapiens OX=9606 GN=USP13 PE=1 SV=2" "0.000" "False" "61.220" "21" "15" "21" "15" "863" "97.3" "5.53" "61.30" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8975" "ENSG00000058056" "USP13" "A8K2S3; B4DYF3; D3DNS2; hsa:8975; Q92995; Q96B25" "Ub-specific processing proteases; Regulation of PTEN stability and activity" "" "2" "0" "1.009" "1.027" "1.029" "0.999" "0.982" "0.943" "1.012" "1.060" "1.019" "1323.2" "1334.6" "1358.4" "1361.1" "1322.3" "1299.1" "1247.8" "1339.6" "1403.3" "1347.7" "" "" "" "" "" "" "" "" "" "" "1062.8" "963.0" "1079.0" "911.9" "914.5" "974.7" "873.7" "978.3" "1403.3" "1096.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7190222159830229495" "False" "High" "IsMasterProtein" "Q9H0A0" "RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2" "0.000" "False" "61.106" "13" "13" "15" "13" "1025" "115.7" "8.27" "53.63" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05127, Pf08351, Pf13718, Pf13725" "55226" "ENSG00000135372" "NAT10" "B4DFD5; E7ESU4; E9PMN9; hsa:55226; Q86WK5; Q9C0F4; Q9H0A0; Q9HA61; Q9NVF2" "rRNA modification in the nucleus and cytosol" "Metapathway biotransformation Phase I and II" "2" "0" "1.025" "1.272" "1.219" "1.037" "1.144" "1.287" "1.131" "1.015" "1.136" "823.7" "844.5" "1047.9" "1004.3" "853.9" "942.7" "1059.8" "931.4" "836.2" "935.4" "" "" "" "" "" "" "" "" "" "" "661.6" "609.4" "832.4" "672.9" "590.5" "707.3" "742.0" "680.2" "836.2" "760.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8718116979404921777" "False" "High" "IsMasterProtein" "P51116" "RNA-binding protein FXR2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2" "0.000" "False" "61.076" "22" "12" "16" "9" "673" "74.2" "6.23" "51.49" "12" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf17904, Pf18336" "9513" "ENSG00000129245" "FXR2" "B2R9M2; D3DTQ1; hsa:9513; P51116; Q86V09; Q8WUM2" "" "VEGFA-VEGFR2 signaling" "1" "1" "0.983" "0.949" "1.037" "1.014" "1.017" "1.050" "0.990" "1.064" "1.026" "515.1" "506.1" "488.7" "534.1" "522.5" "523.9" "541.0" "510.1" "548.1" "528.3" "" "" "" "" "" "" "" "" "" "" "413.7" "365.2" "388.2" "357.8" "361.4" "393.1" "378.8" "372.5" "548.1" "429.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4061147392346931585" "False" "High" "IsMasterProtein" "P61006" "Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1" "0.000" "False" "61.031" "42" "10" "21" "4" "207" "23.7" "9.07" "70.27" "10" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "4218" "ENSG00000167461" "RAB8A" "B4DEK7; hsa:4218; P24407; P61006; Q6FHV5" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; VxPx cargo-targeting to cilium; TBC/RABGAPs" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome" "10" "3" "0.924" "0.983" "0.929" "0.962" "0.950" "0.965" "0.872" "0.993" "1.018" "880.5" "813.7" "865.2" "818.0" "847.5" "836.4" "849.8" "767.7" "874.2" "896.0" "" "" "" "" "" "" "" "" "" "" "707.2" "587.1" "687.3" "548.1" "586.1" "627.6" "595.0" "560.7" "874.2" "728.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4976528031312254709" "False" "High" "IsMasterProtein" "Q92506" "(3R)-3-hydroxyacyl-CoA dehydrogenase OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "0.000" "False" "60.975" "37" "8" "13" "8" "261" "27.0" "6.54" "49.15" "8" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "Fatty acyl-CoA biosynthesis" "" "1" "0" "1.054" "0.978" "1.074" "1.065" "1.012" "1.014" "0.972" "1.055" "1.044" "1228.8" "1295.4" "1201.2" "1320.0" "1309.3" "1243.3" "1246.4" "1195.0" "1296.6" "1282.6" "" "" "" "" "" "" "" "" "" "" "987.0" "934.8" "954.2" "884.4" "905.5" "932.8" "872.7" "872.7" "1296.6" "1043.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2546736599525709996" "False" "High" "IsMasterProtein" "Q8N1G2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1" "0.000" "False" "60.962" "18" "14" "19" "14" "835" "95.3" "7.05" "59.80" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf01728" "23070" "ENSG00000137200" "CMTR1" "A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9" "" "" "0" "0" "1.007" "0.966" "1.029" "0.974" "0.937" "0.974" "0.958" "0.956" "0.971" "1586.2" "1596.7" "1531.8" "1631.7" "1545.1" "1485.7" "1545.0" "1520.0" "1515.8" "1540.6" "" "" "" "" "" "" "" "" "" "" "1274.1" "1152.1" "1216.8" "1093.2" "1068.6" "1114.7" "1081.7" "1110.1" "1515.8" "1252.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8005629595719536467" "False" "High" "IsMasterProtein" "Q12840" "Kinesin heavy chain isoform 5A OS=Homo sapiens OX=9606 GN=KIF5A PE=1 SV=2" "0.000" "False" "60.893" "10" "9" "22" "1" "1032" "117.3" "5.90" "65.78" "9" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3798" "ENSG00000155980" "KIF5A" "A6H8M5; hsa:3798; Q12840; Q4LE26" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Insulin processing; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "7" "0" "1.228" "1.085" "1.084" "1.023" "1.010" "1.025" "0.978" "1.017" "0.962" "204.3" "250.9" "221.6" "221.5" "209.0" "206.4" "209.3" "199.8" "207.7" "196.5" "" "" "" "" "" "" "" "" "" "" "164.1" "181.1" "176.0" "148.4" "144.6" "154.9" "146.5" "145.9" "207.7" "159.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400843138587659979" "False" "High" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "0.000" "False" "60.763" "15" "13" "15" "11" "930" "103.5" "5.97" "48.21" "13" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "" "2" "1" "0.989" "1.080" "1.052" "1.023" "1.027" "1.100" "1.026" "1.015" "1.037" "1088.1" "1076.4" "1175.7" "1144.8" "1113.1" "1118.1" "1196.9" "1116.0" "1104.0" "1128.0" "" "" "" "" "" "" "" "" "" "" "874.0" "776.7" "933.9" "767.0" "769.8" "838.9" "838.0" "815.0" "1104.0" "917.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285089334394207834" "False" "High" "IsMasterProtein" "Q12959" "Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2" "0.000" "False" "60.761" "12" "9" "10" "7" "904" "100.4" "5.76" "37.97" "9" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf09058, Pf10600, Pf10608" "1739" "ENSG00000075711" "DLG1" "A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21; hsa:1739; Q12958; Q12959" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome; Cell lineage map for neuronal differentiation" "15" "1" "0.979" "0.915" "1.016" "1.012" "1.002" "0.959" "1.068" "1.071" "0.989" "677.1" "663.2" "619.3" "687.9" "685.0" "678.4" "649.5" "723.0" "725.3" "669.4" "" "" "" "" "" "" "" "" "" "" "543.8" "478.5" "491.9" "460.9" "473.8" "509.0" "454.8" "528.0" "725.3" "544.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2621085061721332365" "False" "High" "IsMasterProtein" "P48382" "DNA-binding protein RFX5 OS=Homo sapiens OX=9606 GN=RFX5 PE=1 SV=1" "0.000" "False" "60.759" "16" "8" "12" "8" "616" "65.3" "9.29" "41.95" "8" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf14621, Pf18326" "5993" "ENSG00000143390" "RFX5" "B7Z848; D3DV19; E9PFU4; hsa:5993; P48382; Q5VWC3" "" "Prion disease pathway; IL-18 signaling pathway" "2" "0" "1.027" "1.036" "1.083" "0.984" "0.904" "0.929" "0.904" "0.972" "0.957" "735.2" "755.3" "761.5" "796.4" "723.7" "664.8" "683.3" "664.8" "714.4" "703.4" "" "" "" "" "" "" "" "" "" "" "590.5" "545.0" "604.9" "533.6" "500.5" "498.8" "478.4" "485.5" "714.4" "572.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470194220236547975" "False" "High" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "0.000" "False" "60.695" "32" "10" "13" "10" "312" "35.1" "9.13" "47.57" "10" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "0.929" "0.941" "0.957" "0.945" "0.942" "0.890" "0.930" "0.942" "0.927" "1856.8" "1725.1" "1747.0" "1776.5" "1755.5" "1748.5" "1652.2" "1727.1" "1749.7" "1720.4" "" "" "" "" "" "" "" "" "" "" "1491.3" "1244.8" "1387.7" "1190.2" "1214.1" "1311.9" "1156.8" "1261.3" "1749.7" "1399.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1447147241946060131" "False" "High" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "0.000" "False" "60.641" "75" "8" "83" "8" "102" "10.9" "8.92" "248.46" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "RHOG GTPase cycle" "" "1" "0" "1.043" "1.045" "1.033" "1.068" "1.036" "1.050" "1.113" "0.976" "0.991" "8997.8" "9385.9" "9399.8" "9294.3" "9613.0" "9321.6" "9445.1" "10016.3" "8778.9" "8919.5" "" "" "" "" "" "" "" "" "" "" "7226.9" "6772.6" "7466.5" "6227.2" "6648.4" "6993.8" "6612.9" "7314.9" "8778.9" "7253.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1393255483118757770" "False" "High" "IsMasterProtein" "Q9H2U2" "Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2" "0.000" "False" "60.629" "34" "10" "22" "9" "334" "37.9" "7.39" "72.14" "10" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00719" "27068" "ENSG00000138777" "PPA2" "B4DLP7; F8WDN9; hsa:27068; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9H2U2; Q9NX37; Q9P033; Q9ULX0" "Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis" "" "2" "0" "0.909" "0.923" "0.886" "0.975" "0.976" "0.941" "0.967" "0.978" "0.967" "1683.2" "1529.5" "1554.0" "1491.1" "1641.1" "1642.1" "1583.8" "1627.2" "1645.5" "1627.2" "" "" "" "" "" "" "" "" "" "" "1351.9" "1103.6" "1234.4" "999.0" "1135.0" "1232.0" "1108.9" "1188.3" "1645.5" "1323.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3143696315815793188" "False" "High" "IsMasterProtein" "Q8WXH0" "Nesprin-2 OS=Homo sapiens OX=9606 GN=SYNE2 PE=1 SV=3" "0.000" "False" "60.603" "3" "22" "23" "21" "6885" "795.9" "5.36" "56.59" "22" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23224" "ENSG00000054654" "SYNE2" "B4DND7; B4DPR6; I6XXQ5; Q540G1; Q86YP9; Q8N1S3; Q8NF49; Q8TER7; Q8WWW3; Q8WWW4; Q8WWW5; Q8WXH0; Q8WXH1; Q9NU50; Q9UFQ4; Q9Y2L4; Q9Y4R1" "Meiotic synapsis" "Ovarian infertility; Rett syndrome; Envelope proteins and their potential roles in EDMD physiopathology" "4" "0" "1.013" "0.988" "0.988" "0.927" "1.031" "1.027" "1.009" "1.037" "1.030" "682.8" "691.7" "674.7" "674.4" "633.2" "704.1" "701.2" "688.9" "707.7" "703.0" "" "" "" "" "" "" "" "" "" "" "548.4" "499.1" "536.0" "451.9" "437.9" "528.3" "490.9" "503.1" "707.7" "571.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139328666383470964" "False" "High" "IsMasterProtein" "Q8IZH2" "5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1" "0.000" "False" "60.560" "10" "14" "14" "14" "1706" "194.0" "7.21" "46.58" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846, Pf18129, Pf18332, Pf18334" "54464" "ENSG00000114127" "XRN1" "hsa:54464; Q4G0S3; Q68D88; Q6AI24; Q6MZS8; Q86WS7; Q8IZH2; Q8N8U4; Q9UF39" "mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "miRNA degrading enzymes" "4" "0" "1.036" "0.952" "1.034" "1.063" "1.025" "0.986" "1.051" "1.014" "1.034" "1166.0" "1208.0" "1109.4" "1205.2" "1239.8" "1195.6" "1149.5" "1224.9" "1181.8" "1206.1" "" "" "" "" "" "" "" "" "" "" "936.5" "871.7" "881.3" "807.5" "857.5" "897.0" "804.8" "894.5" "1181.8" "980.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6887775823956767803" "False" "High" "IsMasterProtein" "P25440" "Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2" "0.000" "False" "60.456" "14" "12" "16" "11" "801" "88.0" "9.09" "55.78" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf17035" "6046" "ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307" "BRD2" "A2AAU0; B0S7P0; B1AZT1; O00699; O00700; P25440; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4" "RUNX3 regulates p14-ARF" "" "1" "0" "0.965" "0.970" "0.975" "1.000" "0.929" "1.055" "1.175" "1.102" "1.022" "1174.3" "1132.8" "1138.5" "1144.5" "1174.0" "1090.5" "1238.4" "1379.8" "1294.2" "1200.0" "" "" "" "" "" "" "" "" "" "" "943.2" "817.4" "904.4" "766.8" "811.9" "818.2" "867.0" "1007.7" "1294.2" "975.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293533738236197165" "False" "High" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "0.000" "False" "60.427" "61" "9" "35" "9" "108" "12.8" "5.29" "112.66" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "Post-chaperonin tubulin folding pathway" "VEGFA-VEGFR2 signaling" "2" "0" "1.060" "1.032" "1.074" "1.071" "1.135" "1.032" "1.109" "1.047" "1.067" "4120.2" "4367.0" "4251.4" "4425.6" "4414.6" "4677.4" "4250.3" "4571.1" "4314.0" "4394.3" "" "" "" "" "" "" "" "" "" "" "3309.3" "3151.1" "3377.0" "2965.2" "3053.2" "3509.4" "2975.8" "3338.3" "4314.0" "3573.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178776459123092866" "False" "High" "IsMasterProtein" "P05387" "Large ribosomal subunit protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "0.000" "False" "60.421" "56" "6" "17" "6" "115" "11.7" "4.54" "54.94" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "16" "0" "1.063" "1.119" "1.113" "1.062" "1.058" "1.113" "1.083" "1.069" "1.022" "976.7" "1038.6" "1092.7" "1087.2" "1037.8" "1033.2" "1087.1" "1058.0" "1043.9" "998.1" "" "" "" "" "" "" "" "" "" "" "784.5" "749.5" "868.0" "728.4" "717.7" "775.2" "761.1" "772.7" "1043.9" "811.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370234138651289741" "False" "High" "IsMasterProtein" "Q96RS0" "Trimethylguanosine synthase OS=Homo sapiens OX=9606 GN=TGS1 PE=1 SV=3" "0.000" "False" "60.379" "18" "10" "11" "10" "853" "96.6" "4.94" "38.86" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09445" "96764" "ENSG00000137574" "TGS1" "A6NJQ5; hsa:96764; Q5GH23; Q8TDG9; Q96QU3; Q96RS0; Q9H5V3" "Heme signaling; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly" "" "11" "0" "1.026" "0.952" "1.126" "1.060" "0.965" "1.076" "1.057" "0.963" "1.049" "458.2" "470.0" "436.0" "515.8" "485.5" "442.4" "493.0" "484.2" "441.2" "480.6" "" "" "" "" "" "" "" "" "" "" "368.0" "339.2" "346.4" "345.6" "335.8" "331.9" "345.2" "353.6" "441.2" "390.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3321226471008760" "False" "High" "IsMasterProtein" "Q9Y2Q3" "Glutathione S-transferase kappa 1 OS=Homo sapiens OX=9606 GN=GSTK1 PE=1 SV=3" "0.000" "False" "60.350" "53" "9" "12" "9" "226" "25.5" "8.41" "39.46" "9" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf01323" "373156" "ENSG00000197448" "GSTK1" "B4DIH1; B4DSY2; hsa:373156; Q6P4H0; Q7Z520; Q9P1S4; Q9Y2Q3" "Peroxisomal protein import; Glutathione conjugation" "Metapathway biotransformation Phase I and II" "3" "0" "1.034" "0.993" "1.020" "1.039" "0.985" "1.058" "1.140" "1.059" "1.027" "961.6" "994.4" "954.4" "980.7" "999.0" "947.6" "1017.0" "1096.2" "1018.6" "987.2" "" "" "" "" "" "" "" "" "" "" "772.4" "717.5" "758.1" "657.1" "690.9" "711.0" "712.1" "800.6" "1018.6" "802.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3252394429536465777" "False" "High" "IsMasterProtein" "Q32P41" "tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=3" "0.000" "False" "60.307" "23" "11" "16" "11" "509" "58.2" "8.62" "55.77" "11" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02475" "57570" "ENSG00000126814" "TRMT5" "B2RN19; hsa:57570; Q32P41; Q9P2F4" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "0.989" "0.993" "1.018" "1.018" "1.029" "0.974" "0.996" "0.969" "1.046" "1684.0" "1665.3" "1672.0" "1715.0" "1714.4" "1733.5" "1640.9" "1677.0" "1632.0" "1761.5" "" "" "" "" "" "" "" "" "" "" "1352.6" "1201.7" "1328.1" "1149.1" "1185.7" "1300.6" "1148.8" "1224.7" "1632.0" "1432.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491921153129945541" "False" "High" "IsMasterProtein" "Q9UHV9" "Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1" "0.000" "False" "60.283" "42" "5" "16" "5" "154" "16.6" "6.58" "58.81" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5202" "ENSG00000143256" "PFDN2" "hsa:5202; Q9P0P7; Q9UHV9; Q9UN05" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.110" "1.025" "1.168" "1.049" "0.984" "1.168" "1.049" "0.976" "1.006" "1396.2" "1549.3" "1431.2" "1630.6" "1464.9" "1373.7" "1630.5" "1465.0" "1363.2" "1404.0" "" "" "" "" "" "" "" "" "" "" "1121.4" "1117.9" "1136.8" "1092.5" "1013.1" "1030.7" "1141.6" "1069.9" "1363.2" "1141.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7598274604461767952" "False" "High" "IsMasterProtein" "P49750" "YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4" "0.000" "False" "60.278" "7" "15" "18" "15" "2146" "241.5" "6.55" "57.80" "15" "other biological processes" "nucleus" "" "Pf13671" "56252" "ENSG00000119596" "YLPM1" "hsa:56252; P49750; P49752; Q96I64; Q9P1V7" "" "" "0" "0" "0.868" "1.012" "1.013" "1.016" "1.013" "1.070" "0.994" "1.104" "0.976" "1051.4" "913.1" "1064.4" "1065.2" "1068.2" "1065.4" "1124.5" "1044.6" "1161.1" "1025.9" "" "" "" "" "" "" "" "" "" "" "844.5" "658.8" "845.5" "713.7" "738.8" "799.3" "787.3" "762.9" "1161.1" "834.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425175822669482526" "False" "High" "IsMasterProtein" "Q9NRY5" "Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4" "0.000" "False" "60.267" "17" "9" "12" "9" "505" "55.4" "4.88" "47.51" "9" "" "" "other molecular function" "Pf05334" "10827" "ENSG00000055147" "FAM114A2" "B2R8D8; hsa:10827; Q9H7E0; Q9NRY5" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "1.034" "0.940" "0.948" "0.943" "0.897" "0.798" "0.948" "0.949" "0.947" "1097.0" "1134.6" "1031.1" "1039.6" "1034.6" "983.8" "874.9" "1040.3" "1041.0" "1038.4" "" "" "" "" "" "" "" "" "" "" "881.1" "818.7" "819.1" "696.5" "715.6" "738.1" "612.6" "759.7" "1041.0" "844.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7016247097338811422" "False" "High" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "0.000" "False" "60.249" "29" "11" "15" "11" "420" "46.9" "8.54" "49.70" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf21369" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "mRNA Splicing - Major Pathway" "" "1" "0" "0.999" "1.044" "0.971" "0.976" "0.954" "0.926" "0.954" "1.012" "0.988" "1693.4" "1691.3" "1767.5" "1644.5" "1653.0" "1615.4" "1567.3" "1615.0" "1713.5" "1673.8" "" "" "" "" "" "" "" "" "" "" "1360.1" "1220.4" "1404.0" "1101.8" "1143.2" "1212.0" "1097.4" "1179.4" "1713.5" "1361.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635739719901529146" "False" "High" "IsMasterProtein" "Q8TB03" "Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1" "0.000" "False" "60.209" "42" "10" "13" "10" "319" "36.6" "6.30" "41.56" "10" "" "" "" "Pf15112" "159013" "ENSG00000185753" "CXorf38" "B3KW28; D3DWB5; hsa:159013; Q5JPF5; Q8N941; Q8TB03" "" "" "0" "0" "0.981" "0.894" "1.001" "0.883" "1.032" "0.934" "0.857" "0.950" "0.943" "456.5" "447.9" "408.3" "456.8" "403.1" "471.0" "426.4" "391.4" "433.5" "430.3" "" "" "" "" "" "" "" "" "" "" "366.7" "323.2" "324.3" "306.0" "278.8" "353.4" "298.6" "285.8" "433.5" "349.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1178215793923997367" "False" "High" "IsMasterProtein" "Q96DM3" "Regulator of MON1-CCZ1 complex OS=Homo sapiens OX=9606 GN=RMC1 PE=1 SV=2" "0.000" "False" "60.135" "20" "10" "14" "10" "657" "74.9" "7.83" "48.47" "10" "other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle" "" "Pf07035, Pf21029" "29919" "ENSG00000141452" "RMC1" "Q96DM3; Q9BU17; Q9Y5M0" "" "" "0" "0" "1.007" "0.987" "1.048" "1.035" "0.987" "0.979" "0.979" "0.997" "1.027" "1112.3" "1120.6" "1098.3" "1165.5" "1150.7" "1097.3" "1089.1" "1089.2" "1109.4" "1142.1" "" "" "" "" "" "" "" "" "" "" "893.4" "808.6" "872.4" "780.9" "795.9" "823.3" "762.5" "795.5" "1109.4" "928.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506961570143965113" "False" "High" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "0.000" "False" "60.103" "55" "9" "29" "9" "189" "19.9" "6.79" "96.66" "9" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway; HDAC6 interactions in the central nervous system" "8" "0" "1.071" "1.046" "1.065" "1.065" "1.020" "1.040" "0.963" "1.061" "0.987" "2521.0" "2699.8" "2636.7" "2683.8" "2684.5" "2572.3" "2621.9" "2426.8" "2673.6" "2487.2" "" "" "" "" "" "" "" "" "" "" "2024.8" "1948.1" "2094.5" "1798.2" "1856.6" "1930.0" "1835.7" "1772.3" "2673.6" "2022.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8469309847663247920" "False" "High" "IsMasterProtein" "Q9UEY8" "Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1" "0.000" "False" "60.101" "19" "11" "13" "11" "706" "79.1" "6.32" "45.02" "11" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "120" "ENSG00000148700" "ADD3" "D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8" "Miscellaneous transport and binding events; RHOD GTPase cycle; RHOF GTPase cycle" "" "3" "0" "0.978" "0.989" "0.957" "0.967" "0.970" "0.926" "0.962" "0.974" "0.976" "1395.4" "1364.8" "1379.4" "1334.8" "1348.8" "1353.9" "1292.1" "1342.4" "1359.1" "1361.5" "" "" "" "" "" "" "" "" "" "" "1120.7" "984.8" "1095.7" "894.3" "932.8" "1015.8" "904.6" "980.4" "1359.1" "1107.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785444937320200778" "False" "High" "IsMasterProtein" "P17544" "Cyclic AMP-dependent transcription factor ATF-7 OS=Homo sapiens OX=9606 GN=ATF7 PE=1 SV=3" "0.000" "False" "60.087" "23" "10" "15" "6" "483" "51.7" "8.00" "62.90" "10" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "11016" "ENSG00000170653" "ATF7" "A5D6Y4; B2RMP1; B4DQL4; hsa:11016; P17544; Q13814; Q8IVR8; Q9UD83" "" "" "0" "2" "0.941" "0.946" "0.976" "0.966" "0.932" "0.976" "0.988" "0.961" "0.978" "865.7" "814.2" "818.7" "844.5" "835.9" "807.0" "844.6" "855.5" "832.1" "846.9" "" "" "" "" "" "" "" "" "" "" "695.3" "587.5" "650.3" "565.8" "578.1" "605.5" "591.4" "624.8" "832.1" "688.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5750940690254382676" "False" "High" "IsMasterProtein" "P16333" "SH2/SH3 adapter protein NCK1 OS=Homo sapiens OX=9606 GN=NCK1 PE=1 SV=1" "0.000" "False" "59.986" "29" "10" "17" "10" "377" "42.8" "6.47" "58.79" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "4690" "ENSG00000158092" "NCK1" "B7Z751; D3DNE3; hsa:4690; P16333" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; RHO GTPases Activate WASPs and WAVEs; PKR-mediated signaling; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; DCC mediated attractive signaling; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Activation of RAC1" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; GDNF signaling; ErbB signaling pathway; T-cell receptor signaling pathway" "27" "0" "0.971" "1.041" "0.975" "0.950" "0.973" "0.914" "0.963" "1.002" "0.982" "1683.1" "1633.7" "1751.7" "1641.7" "1599.3" "1637.9" "1539.0" "1620.1" "1686.1" "1652.5" "" "" "" "" "" "" "" "" "" "" "1351.8" "1178.9" "1391.4" "1099.9" "1106.1" "1228.9" "1077.6" "1183.2" "1686.1" "1343.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3944775931209301438" "False" "High" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "0.000" "False" "59.965" "59" "8" "34" "6" "151" "16.9" "4.65" "108.77" "8" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Ciliary landscape" "8" "2" "0.963" "1.014" "1.043" "1.022" "1.072" "1.107" "1.083" "1.050" "0.999" "3648.5" "3513.9" "3701.3" "3805.7" "3729.5" "3912.1" "4037.5" "3950.9" "3831.6" "3643.5" "" "" "" "" "" "" "" "" "" "" "2930.4" "2535.5" "2940.1" "2549.8" "2579.4" "2935.2" "2826.9" "2885.3" "3831.6" "2963.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4992003344612717305" "False" "High" "IsMasterProtein" "P30260" "Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2" "0.000" "False" "59.949" "12" "10" "14" "10" "824" "91.8" "7.02" "52.20" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00515, Pf12895" "996" "ENSG00000004897" "CDC27" "G3V1C4; hsa:996; P30260; Q16349; Q96F35" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle; 2q21.1 copy number variation syndrome" "20" "0" "1.077" "1.035" "0.986" "0.937" "0.952" "0.908" "1.011" "0.986" "0.959" "1744.6" "1878.1" "1806.1" "1720.4" "1635.0" "1661.6" "1583.9" "1763.2" "1720.5" "1673.5" "" "" "" "" "" "" "" "" "" "" "1401.2" "1355.2" "1434.6" "1152.6" "1130.8" "1246.7" "1109.0" "1287.7" "1720.5" "1360.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "280272277997118017" "False" "High" "IsMasterProtein" "Q9Y316" "Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1" "0.000" "False" "59.837" "40" "10" "14" "10" "297" "33.7" "7.14" "49.91" "10" "other biological processes" "" "" "Pf01875" "51072" "ENSG00000162959" "MEMO1" "B4DLS0; D6W575; hsa:51072; Q5R2V8; Q5R2V9; Q6NSL5; Q9Y316" "ERBB2 Regulates Cell Motility" "" "1" "0" "0.953" "0.982" "0.953" "1.002" "1.031" "1.001" "1.008" "1.006" "0.990" "1574.4" "1501.0" "1546.5" "1500.3" "1577.5" "1623.0" "1575.8" "1586.5" "1583.2" "1558.3" "" "" "" "" "" "" "" "" "" "" "1264.5" "1083.1" "1228.5" "1005.2" "1091.0" "1217.7" "1103.3" "1158.6" "1583.2" "1267.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6054246856873050357" "False" "High" "IsMasterProtein" "Q15118" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1" "0.000" "False" "59.822" "19" "7" "16" "7" "436" "49.2" "8.81" "55.69" "7" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "5163" "ENSG00000152256" "PDK1" "B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "T cell receptor and co-stimulatory signaling; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Hereditary leiomyomatosis and renal cell carcinoma pathway; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; GNAQ pathways in port-wine stain; EPO receptor signaling; DNA damage response (only ATM dependent)" "23" "0" "0.969" "0.968" "1.027" "1.022" "0.990" "0.888" "0.894" "0.858" "0.955" "604.0" "585.5" "584.9" "620.1" "617.2" "597.7" "536.5" "539.7" "518.2" "576.8" "" "" "" "" "" "" "" "" "" "" "485.1" "422.5" "464.6" "415.5" "426.9" "448.5" "375.6" "394.2" "518.2" "469.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819475231177228561" "False" "High" "IsMasterProtein" "O94966" "Ubiquitin carboxyl-terminal hydrolase 19 OS=Homo sapiens OX=9606 GN=USP19 PE=1 SV=2" "0.000" "False" "59.806" "10" "11" "12" "11" "1318" "145.6" "6.28" "43.61" "11" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00443, Pf01753, Pf04969, Pf16602" "10869" "ENSG00000172046" "USP19" "A5PKX8; A6H8U2; B4DGT3; B4DTZ0; E7EN22; E7ETS0; E9PEG8; hsa:10869; O94966; Q3KQW4; Q641Q9; Q6NZY8; Q86XV9" "Ub-specific processing proteases" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "2" "0" "1.038" "0.962" "0.943" "0.900" "0.891" "0.875" "0.927" "0.866" "0.988" "326.2" "338.5" "313.7" "307.5" "293.5" "290.8" "285.4" "302.3" "282.4" "322.4" "" "" "" "" "" "" "" "" "" "" "262.0" "244.2" "249.2" "206.0" "203.0" "218.2" "199.8" "220.8" "282.4" "262.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139942290346830630" "False" "High" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "0.000" "False" "59.709" "38" "10" "22" "10" "290" "31.4" "8.07" "72.37" "10" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "10" "0" "0.946" "0.932" "0.956" "1.004" "0.945" "0.966" "0.929" "0.914" "0.979" "2058.8" "1946.7" "1918.5" "1968.6" "2067.2" "1946.0" "1987.8" "1911.7" "1881.0" "2015.1" "" "" "" "" "" "" "" "" "" "" "1653.6" "1404.7" "1523.9" "1319.0" "1429.7" "1460.0" "1391.8" "1396.1" "1881.0" "1638.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373690399274413822" "False" "High" "IsMasterProtein" "Q8N543" "Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1" "0.000" "False" "59.687" "22" "9" "19" "9" "542" "63.2" "5.11" "63.92" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10637, Pf13661" "55239" "ENSG00000087263" "OGFOD1" "H3BUQ2; hsa:55239; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6" "Protein hydroxylation" "" "1" "0" "1.050" "0.930" "1.056" "0.938" "0.910" "0.975" "0.906" "0.922" "0.961" "952.3" "999.9" "885.5" "1005.4" "893.1" "866.2" "928.6" "863.1" "878.1" "915.1" "" "" "" "" "" "" "" "" "" "" "764.9" "721.5" "703.4" "673.6" "617.7" "649.9" "650.2" "630.4" "878.1" "744.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611257715597886633" "False" "High" "IsMasterProtein" "Q15555" "Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1" "0.000" "False" "59.607" "23" "8" "18" "8" "327" "37.0" "5.57" "66.62" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "10982" "ENSG00000166974" "MAPRE2" "B2RE21; B3KR39; B4DJV4; B7Z2L3; E9PHR3; F5H1V8; G5E9I6; hsa:10982; Q15555; Q9UQ33" "" "Ciliary landscape" "1" "0" "0.996" "1.020" "0.959" "0.956" "0.952" "0.946" "1.002" "1.008" "0.979" "2807.5" "2797.2" "2862.5" "2691.3" "2683.9" "2672.9" "2656.0" "2812.4" "2828.9" "2748.9" "" "" "" "" "" "" "" "" "" "" "2254.9" "2018.4" "2273.8" "1803.2" "1856.2" "2005.4" "1859.6" "2053.9" "2828.9" "2235.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033578792166200150" "False" "High" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "0.000" "False" "59.594" "33" "11" "29" "10" "332" "36.2" "8.21" "90.40" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "" "Pre-implantation embryo; mRNA processing" "2" "0" "0.992" "1.036" "1.018" "1.003" "1.080" "1.084" "1.061" "1.020" "1.011" "2497.9" "2478.8" "2587.5" "2543.1" "2504.8" "2698.5" "2707.7" "2650.1" "2549.1" "2525.3" "" "" "" "" "" "" "" "" "" "" "2006.3" "1788.6" "2055.3" "1703.9" "1732.3" "2024.6" "1895.8" "1935.3" "2549.1" "2053.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2934429115890705699" "False" "High" "IsMasterProtein" "P49821" "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4" "0.000" "False" "59.592" "34" "13" "16" "13" "464" "50.8" "8.21" "45.79" "13" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion" "transporter activity;other molecular function" "Pf01512, Pf10589" "4723" "ENSG00000167792" "NDUFV1" "hsa:4723; O60924; O60940; P49821; Q16104; Q6IBR3; Q96BF8; Q96HS7" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; HDAC6 interactions in the central nervous system; Oxidative phosphorylation" "7" "0" "1.016" "1.048" "0.991" "1.022" "1.038" "0.962" "1.045" "1.035" "1.033" "981.6" "997.5" "1028.7" "972.8" "1003.2" "1018.5" "944.5" "1026.1" "1015.8" "1013.6" "" "" "" "" "" "" "" "" "" "" "788.4" "719.8" "817.2" "651.8" "693.8" "764.1" "661.3" "749.3" "1015.8" "824.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2548334964560567831" "False" "High" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "0.000" "False" "59.547" "28" "11" "17" "11" "377" "41.9" "6.65" "55.06" "11" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "1.032" "0.964" "0.996" "1.045" "1.028" "0.978" "0.927" "0.943" "1.024" "1416.8" "1462.0" "1365.5" "1411.0" "1481.2" "1455.8" "1385.2" "1312.7" "1336.6" "1450.5" "" "" "" "" "" "" "" "" "" "" "1138.0" "1054.9" "1084.6" "945.4" "1024.4" "1092.2" "969.9" "958.7" "1336.6" "1179.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2429714834335380006" "False" "High" "IsMasterProtein" "P40818" "Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1" "0.000" "False" "59.537" "13" "14" "20" "14" "1118" "127.4" "8.51" "63.15" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf00581, Pf08969, Pf20625" "9101" "ENSG00000138592" "USP8" "B4DKA8; hsa:9101; P40818; Q2TB31; Q7Z3U2; Q86VA0; Q8IWI7" "Negative regulation of MET activity; Ub-specific processing proteases; Downregulation of ERBB2:ERBB3 signaling; Regulation of FZD by ubiquitination" "EGF/EGFR signaling pathway; Male infertility" "6" "0" "1.017" "1.003" "1.031" "1.034" "1.003" "1.044" "1.002" "0.982" "1.025" "1786.1" "1815.8" "1790.9" "1841.8" "1846.8" "1792.3" "1865.6" "1789.8" "1754.5" "1829.9" "" "" "" "" "" "" "" "" "" "" "1434.6" "1310.2" "1422.6" "1234.0" "1277.3" "1344.7" "1306.2" "1307.1" "1754.5" "1488.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2739049111137792080" "False" "High" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "0.000" "False" "59.505" "38" "13" "17" "13" "404" "45.5" "5.07" "62.76" "13" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "Factors involved in megakaryocyte development and platelet production; GPER1 signaling; FCGR3A-mediated IL10 synthesis; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "Myometrial relaxation and contraction pathways; G protein signaling pathways; TGF-beta signaling pathway; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "22" "0" "1.050" "1.041" "0.979" "1.040" "1.058" "0.988" "1.039" "1.091" "1.056" "2085.5" "2190.6" "2170.1" "2041.4" "2168.8" "2205.5" "2060.4" "2166.9" "2274.5" "2202.5" "" "" "" "" "" "" "" "" "" "" "1675.0" "1580.7" "1723.7" "1367.8" "1499.9" "1654.7" "1442.6" "1582.5" "2274.5" "1791.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2886709730536475345" "False" "High" "IsMasterProtein" "Q9BTT0" "Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1" "0.000" "False" "59.488" "22" "4" "20" "4" "268" "30.7" "3.85" "81.07" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14580" "81611" "ENSG00000143401" "ANP32E" "B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0" "" "" "0" "0" "0.937" "0.976" "0.905" "0.922" "1.011" "1.014" "1.021" "0.974" "0.977" "1709.5" "1602.6" "1668.7" "1547.3" "1576.0" "1727.7" "1732.7" "1744.7" "1664.2" "1670.9" "" "" "" "" "" "" "" "" "" "" "1373.1" "1156.4" "1325.5" "1036.7" "1090.0" "1296.3" "1213.2" "1274.1" "1664.2" "1358.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7011076575076357199" "False" "High" "IsMasterProtein" "O00442" "RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1" "0.000" "False" "59.482" "30" "9" "17" "9" "366" "39.3" "7.85" "56.73" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01137, Pf05189" "8634" "ENSG00000137996" "RTCA" "hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99" "" "" "0" "0" "0.943" "0.974" "1.050" "1.009" "0.940" "0.937" "0.891" "0.906" "0.961" "1488.6" "1403.9" "1450.4" "1563.1" "1502.8" "1400.0" "1395.0" "1326.7" "1348.9" "1431.1" "" "" "" "" "" "" "" "" "" "" "1195.7" "1013.0" "1152.1" "1047.2" "1039.3" "1050.4" "976.7" "968.9" "1348.9" "1163.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004494409327660908" "False" "High" "IsMasterProtein" "P07205" "Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3" "0.000" "False" "59.464" "15" "6" "29" "2" "417" "44.8" "8.54" "102.17" "6" "other metabolic processes;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00162" "5232" "ENSG00000170950" "PGK2" "B2R6Y8; hsa:5232; P07205; Q9H107" "Glycolysis; Gluconeogenesis" "Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "0" "1.037" "1.069" "0.956" "0.939" "1.025" "0.833" "0.914" "0.998" "0.969" "949.3" "984.6" "1014.9" "907.2" "891.1" "972.6" "790.5" "867.3" "947.7" "920.0" "" "" "" "" "" "" "" "" "" "" "762.4" "710.5" "806.2" "607.8" "616.3" "729.7" "553.5" "633.4" "947.7" "748.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8242626749563967556" "False" "High" "IsMasterProtein" "Q9Y606" "Pseudouridylate synthase 1 homolog OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "0.000" "False" "59.432" "30" "13" "18" "13" "427" "47.4" "8.41" "53.12" "13" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "1.024" "1.003" "0.987" "1.006" "0.987" "0.929" "0.954" "0.919" "1.010" "1502.4" "1538.7" "1506.6" "1482.9" "1511.4" "1483.5" "1395.4" "1433.9" "1380.3" "1518.1" "" "" "" "" "" "" "" "" "" "" "1206.7" "1110.3" "1196.8" "993.6" "1045.3" "1113.0" "977.0" "1047.2" "1380.3" "1234.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8496601930648358283" "False" "High" "IsMasterProtein" "Q5T6F2" "Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1" "0.000" "False" "59.351" "12" "10" "16" "10" "1119" "117.0" "7.34" "44.92" "10" "other biological processes" "nucleus;other cell component" "" "Pf12478" "55833" "ENSG00000137073" "UBAP2" "hsa:55833; Q2M2R4; Q5JV03; Q5T6F2; Q6PK34; Q8NC94; Q9P237" "" "" "0" "0" "1.022" "1.018" "1.010" "1.012" "1.036" "1.020" "1.065" "1.075" "0.999" "1168.5" "1193.8" "1189.9" "1179.7" "1182.7" "1211.1" "1192.3" "1244.0" "1255.7" "1166.9" "" "" "" "" "" "" "" "" "" "" "938.5" "861.4" "945.2" "790.4" "817.9" "908.7" "834.8" "908.5" "1255.7" "949.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6094529598036827804" "False" "High" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "0.000" "False" "59.278" "45" "8" "21" "8" "181" "20.6" "8.87" "78.30" "8" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "Neutrophil degranulation" "" "1" "0" "0.970" "0.949" "1.058" "1.020" "1.058" "1.065" "0.954" "0.974" "0.992" "3008.9" "2919.0" "2856.4" "3182.6" "3069.5" "3183.3" "3204.9" "2871.3" "2930.1" "2984.4" "" "" "" "" "" "" "" "" "" "" "2416.7" "2106.3" "2268.9" "2132.3" "2122.9" "2388.4" "2243.9" "2096.9" "2930.1" "2427.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5057410005729893010" "False" "High" "IsMasterProtein" "Q7Z4Q2" "HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2" "0.000" "False" "59.276" "18" "11" "15" "11" "680" "74.5" "5.11" "55.12" "11" "transport;other biological processes" "" "other molecular function" "Pf13513" "55027" "ENSG00000155393" "HEATR3" "A8K1N4; hsa:55027; Q7Z4Q2; Q8N525; Q8WV56; Q96CC9; Q9NWN7" "" "" "0" "0" "1.053" "1.060" "0.960" "1.050" "1.069" "0.955" "1.039" "1.000" "1.055" "870.2" "916.2" "922.6" "835.6" "913.3" "929.9" "831.1" "904.5" "870.4" "918.1" "" "" "" "" "" "" "" "" "" "" "698.9" "661.1" "732.8" "559.9" "631.6" "697.7" "581.9" "660.6" "870.4" "746.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179215368678635356" "False" "High" "IsMasterProtein" "Q8IYB8" "ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1" "0.000" "False" "59.215" "17" "11" "15" "11" "786" "87.9" "7.99" "51.86" "11" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00271, Pf12513, Pf18114, Pf18147" "6832" "ENSG00000156502" "SUPV3L1" "A8K301; hsa:6832; O43630; Q8IYB8" "Mitochondrial RNA degradation" "" "1" "0" "1.007" "1.015" "0.990" "1.060" "1.053" "0.964" "1.055" "1.022" "1.044" "1044.3" "1051.3" "1060.2" "1033.8" "1106.5" "1099.5" "1006.2" "1102.1" "1067.8" "1089.9" "" "" "" "" "" "" "" "" "" "" "838.8" "758.6" "842.2" "692.7" "765.3" "825.0" "704.5" "804.9" "1067.8" "886.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5016840321552797541" "False" "High" "IsMasterProtein" "Q96KP1" "Exocyst complex component 2 OS=Homo sapiens OX=9606 GN=EXOC2 PE=1 SV=1" "0.000" "False" "59.184" "13" "11" "12" "11" "924" "104.0" "6.90" "44.56" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01833, Pf15469" "55770" "ENSG00000112685" "EXOC2" "B2RBE6; hsa:55770; Q5JPC8; Q96AN6; Q96KP1; Q9NUZ8; Q9UJM7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Ciliary landscape" "7" "0" "1.014" "1.034" "1.007" "0.976" "0.995" "0.942" "0.999" "1.015" "1.015" "1233.0" "1250.5" "1275.1" "1241.5" "1203.6" "1226.8" "1161.7" "1231.3" "1251.4" "1251.4" "" "" "" "" "" "" "" "" "" "" "990.3" "902.3" "1012.8" "831.8" "832.4" "920.4" "813.4" "899.2" "1251.4" "1017.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375562830836446683" "False" "High" "IsMasterProtein" "Q15386" "Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3" "0.000" "False" "59.181" "15" "12" "12" "12" "1083" "123.8" "6.71" "41.23" "12" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632" "9690" "ENSG00000009335" "UBE3C" "A4D235; A6NCP3; hsa:9690; Q15386; Q8TC15; Q96CR4; Q9UDU3" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.004" "1.012" "0.903" "0.923" "0.937" "0.937" "1.013" "1.002" "0.966" "767.0" "770.3" "776.4" "692.6" "708.2" "718.4" "718.4" "776.8" "768.8" "740.7" "" "" "" "" "" "" "" "" "" "" "616.0" "555.8" "616.7" "464.0" "489.8" "539.0" "503.0" "567.3" "768.8" "602.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3450396974392384393" "False" "High" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "0.000" "False" "59.181" "21" "10" "16" "10" "559" "61.5" "7.50" "60.35" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "0.992" "1.042" "1.043" "1.038" "0.974" "1.161" "1.149" "1.146" "1.067" "973.0" "965.0" "1014.4" "1015.2" "1009.8" "947.3" "1129.7" "1117.8" "1115.4" "1038.0" "" "" "" "" "" "" "" "" "" "" "781.5" "696.3" "805.7" "680.2" "698.4" "710.8" "790.9" "816.3" "1115.4" "844.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072091565905259276" "False" "High" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "0.000" "False" "59.123" "31" "6" "11" "5" "277" "31.6" "6.54" "46.97" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "Degradation of the extracellular matrix; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; Caspase-mediated cleavage of cytoskeletal proteins; NADE modulates death signalling; Other interleukin signaling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "60" "0" "0.962" "0.959" "1.029" "1.013" "1.002" "1.051" "0.997" "1.034" "0.990" "863.9" "831.0" "828.9" "889.3" "875.5" "865.6" "907.6" "861.2" "893.7" "855.5" "" "" "" "" "" "" "" "" "" "" "693.9" "599.6" "658.4" "595.9" "605.5" "649.5" "635.5" "628.9" "893.7" "695.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8194889804076803831" "False" "High" "IsMasterProtein" "Q9UBU9" "Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1" "0.000" "False" "59.121" "19" "10" "14" "10" "619" "70.1" "8.51" "46.82" "10" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02136, Pf03943, Pf09162" "10482" "ENSG00000162231" "NXF1" "B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "mRNA processing" "5" "0" "1.047" "1.074" "1.149" "1.110" "1.111" "1.171" "1.206" "1.201" "1.118" "892.1" "934.2" "958.2" "1025.2" "990.3" "991.2" "1045.1" "1075.7" "1071.0" "997.8" "" "" "" "" "" "" "" "" "" "" "716.5" "674.1" "761.2" "686.9" "684.9" "743.7" "731.7" "785.6" "1071.0" "811.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8528417393103392868" "False" "High" "IsMasterProtein" "Q9BQ04" "RNA-binding protein 4B OS=Homo sapiens OX=9606 GN=RBM4B PE=1 SV=1" "0.000" "False" "59.115" "42" "13" "24" "2" "359" "40.1" "6.74" "70.97" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf00098" "83759" "ENSG00000173914" "RBM4B" "B3KT83; hsa:83759; Q9BQ04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8297311667808919408" "False" "High" "IsMasterProtein" "Q14651" "Plastin-1 OS=Homo sapiens OX=9606 GN=PLS1 PE=1 SV=2" "0.000" "False" "59.062" "15" "8" "30" "4" "629" "70.2" "5.41" "106.17" "8" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00036, Pf00307, Pf13405" "5357" "ENSG00000120756" "PLS1" "A8K2Q1; D3DNG3; hsa:5357; Q14651; Q8NEG6" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "1.163" "0.864" "1.164" "1.153" "0.952" "1.003" "0.980" "1.011" "1.016" "194.5" "226.2" "168.1" "226.4" "224.3" "185.2" "195.2" "190.6" "196.7" "197.6" "" "" "" "" "" "" "" "" "" "" "156.2" "163.3" "133.5" "151.7" "155.1" "138.9" "136.6" "139.2" "196.7" "160.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971569862806086425" "False" "High" "IsMasterProtein" "Q9Y2Z4" "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" "0.000" "False" "59.059" "26" "11" "14" "11" "477" "53.2" "8.98" "52.59" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00579" "51067" "ENSG00000139131" "YARS2" "D3DUW8; hsa:51067; Q9H817; Q9Y2Z4" "Mitochondrial tRNA aminoacylation" "Orexin receptor pathway" "2" "0" "1.047" "1.000" "1.076" "1.196" "1.109" "1.087" "1.117" "1.119" "1.110" "976.1" "1022.3" "975.8" "1050.4" "1167.4" "1082.3" "1061.0" "1090.5" "1092.1" "1083.8" "" "" "" "" "" "" "" "" "" "" "784.0" "737.7" "775.1" "703.7" "807.4" "812.1" "742.9" "796.4" "1092.1" "881.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5757828644476711483" "False" "High" "IsMasterProtein" "Q9NXR1" "Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1 PE=1 SV=3" "0.000" "False" "59.034" "43" "12" "14" "11" "335" "37.7" "5.15" "38.65" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "54820" "ENSG00000072864; ENSG00000275911" "NDE1" "hsa:54820; Q49AQ2; Q9NXR1" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "13" "1" "1.029" "0.982" "1.104" "0.972" "0.983" "0.985" "0.971" "0.971" "1.004" "733.0" "754.4" "720.1" "809.2" "712.6" "720.9" "722.3" "711.6" "711.8" "736.2" "" "" "" "" "" "" "" "" "" "" "588.7" "544.3" "572.0" "542.2" "492.8" "540.9" "505.7" "519.7" "711.8" "598.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4792290450889044309" "False" "High" "IsMasterProtein" "Q96IV0" "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1" "0.000" "False" "59.009" "19" "10" "14" "10" "654" "74.3" "6.89" "45.58" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01841, Pf04721, Pf09409" "55768" "ENSG00000151092" "NGLY1" "B4DJE9; hsa:55768; Q59FB1; Q6PJD8; Q96IV0; Q9BVR8; Q9NR70" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "1" "0" "1.058" "1.066" "1.025" "1.028" "1.005" "1.001" "1.025" "0.980" "1.021" "1021.5" "1080.5" "1089.2" "1047.1" "1050.3" "1027.0" "1022.2" "1047.2" "1001.0" "1043.2" "" "" "" "" "" "" "" "" "" "" "820.5" "779.6" "865.2" "701.6" "726.4" "770.5" "715.7" "764.8" "1001.0" "848.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890686096526149286" "False" "High" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "0.000" "False" "58.990" "37" "11" "22" "11" "325" "36.5" "5.64" "70.37" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400, Pf12894" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "1.013" "1.072" "1.127" "1.193" "1.145" "1.184" "1.171" "1.139" "1.119" "1923.4" "1948.7" "2061.6" "2166.8" "2295.2" "2203.2" "2278.2" "2252.6" "2191.7" "2151.7" "" "" "" "" "" "" "" "" "" "" "1544.9" "1406.1" "1637.6" "1451.7" "1587.4" "1653.0" "1595.1" "1645.1" "2191.7" "1749.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561643854279228847" "False" "High" "IsMasterProtein" "P15927" "Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1" "0.000" "False" "58.979" "35" "6" "13" "6" "270" "29.2" "6.15" "52.09" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08784" "6118" "ENSG00000117748" "RPA2" "hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5" "Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Homologous Recombination (HRR); Meiotic recombination; Regulation of HSF1-mediated heat shock response; Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "38" "0" "0.966" "0.923" "0.942" "0.990" "0.987" "1.026" "1.009" "1.021" "0.984" "1316.3" "1271.4" "1214.6" "1240.2" "1303.2" "1298.6" "1351.1" "1328.6" "1344.1" "1295.4" "" "" "" "" "" "" "" "" "" "" "1057.2" "917.4" "964.8" "830.9" "901.3" "974.3" "946.0" "970.3" "1344.1" "1053.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2413702222549115072" "False" "High" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "0.000" "False" "58.975" "42" "7" "26" "7" "172" "19.6" "4.93" "84.98" "7" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "0.986" "1.017" "1.009" "1.024" "1.051" "1.057" "0.962" "0.947" "1.055" "1083.1" "1068.2" "1101.2" "1092.3" "1108.7" "1138.1" "1144.3" "1042.0" "1025.9" "1142.2" "" "" "" "" "" "" "" "" "" "" "869.9" "770.8" "874.7" "731.9" "766.8" "853.9" "801.2" "760.9" "1025.9" "928.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463024331811541084" "False" "High" "IsMasterProtein" "Q15054" "DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2" "0.000" "False" "58.937" "24" "11" "18" "11" "466" "51.4" "9.35" "58.37" "11" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf09507" "10714" "ENSG00000077514" "POLD3" "B7ZAI6; hsa:10714; Q15054; Q32MZ9; Q32N00" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "26" "0" "0.966" "0.979" "0.914" "0.895" "0.977" "0.911" "1.005" "1.009" "0.959" "1193.4" "1153.4" "1167.9" "1090.6" "1067.5" "1166.3" "1087.1" "1198.9" "1204.0" "1144.3" "" "" "" "" "" "" "" "" "" "" "958.5" "832.3" "927.7" "730.7" "738.3" "875.0" "761.2" "875.6" "1204.0" "930.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7252282534917135675" "False" "High" "IsMasterProtein" "Q15542" "Transcription initiation factor TFIID subunit 5 OS=Homo sapiens OX=9606 GN=TAF5 PE=1 SV=3" "0.000" "False" "58.907" "19" "13" "15" "13" "800" "86.8" "5.64" "48.46" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04494" "6877" "ENSG00000148835" "TAF5" "A8K5B4; B2RMR0; B7ZKJ6; hsa:6877; Q15542; Q53EM4; Q5SYD5; Q86UZ7; Q9Y4K5" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "Eukaryotic transcription initiation" "11" "0" "1.008" "1.054" "1.048" "1.037" "1.028" "1.007" "1.015" "1.073" "1.080" "1153.9" "1162.9" "1216.3" "1209.6" "1196.6" "1185.9" "1162.0" "1171.5" "1238.5" "1246.5" "" "" "" "" "" "" "" "" "" "" "926.8" "839.1" "966.2" "810.4" "827.6" "889.8" "813.5" "855.6" "1238.5" "1013.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749149961980637251" "False" "High" "IsMasterProtein" "P27361" "Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4" "0.000" "False" "58.895" "38" "14" "24" "9" "379" "43.1" "6.74" "69.94" "14" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "5595" "ENSG00000102882" "MAPK3" "A8CZ58; B0LPG3; hsa:5595; P27361; Q8NHX1" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Regulation of PTEN gene transcription; Interferon gamma signaling; RHO GTPases Activate NADPH Oxidases; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; ISG15 antiviral mechanism; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; RNA Polymerase I Promoter Opening; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Polycystic kidney disease pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; 2q11.2 copy number variation syndrome; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "178" "0" "1.062" "1.079" "1.090" "1.035" "1.064" "1.081" "1.007" "1.095" "1.076" "924.4" "981.4" "997.4" "1007.3" "957.0" "983.6" "999.1" "930.7" "1012.3" "994.7" "" "" "" "" "" "" "" "" "" "" "742.4" "708.1" "792.2" "674.9" "661.9" "738.0" "699.5" "679.7" "1012.3" "808.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "201437280160465728" "False" "High" "IsMasterProtein" "Q9H9E3" "Conserved oligomeric Golgi complex subunit 4 OS=Homo sapiens OX=9606 GN=COG4 PE=1 SV=3" "0.000" "False" "58.884" "21" "13" "17" "13" "785" "89.0" "5.19" "44.61" "13" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf08318, Pf20662, Pf20663" "25839" "ENSG00000103051" "COG4" "B4DMN8; C9JS23; hsa:25839; Q96D40; Q9BRF0; Q9BVZ2; Q9H5Y4; Q9H9E3; Q9Y3W3" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "0.936" "0.953" "0.971" "0.948" "0.949" "0.904" "0.992" "0.955" "1.001" "1003.7" "939.7" "956.2" "975.0" "951.1" "952.7" "907.6" "995.8" "958.7" "1004.8" "" "" "" "" "" "" "" "" "" "" "806.1" "678.1" "759.5" "653.3" "657.8" "714.8" "635.5" "727.3" "958.7" "817.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-189490632571161728" "False" "High" "IsMasterProtein" "Q9P2E3" "NFX1-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=ZNFX1 PE=1 SV=2" "0.000" "False" "58.877" "8" "13" "15" "13" "1918" "220.1" "7.30" "46.66" "13" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13086, Pf13087, Pf20173" "57169" "ENSG00000124201" "ZNFX1" "hsa:57169; Q9BQM7; Q9BQM8; Q9H8C1; Q9H9S2; Q9NUM1; Q9NWW1; Q9P2E3" "" "" "0" "0" "1.059" "1.025" "1.117" "1.053" "1.089" "1.023" "1.117" "1.090" "1.052" "433.3" "458.8" "444.0" "484.1" "456.4" "472.0" "443.1" "484.1" "472.3" "455.8" "" "" "" "" "" "" "" "" "" "" "348.0" "331.1" "352.7" "324.3" "315.7" "354.2" "310.3" "353.5" "472.3" "370.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8296927392794764826" "False" "High" "IsMasterProtein" "Q9BZL4" "Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C PE=1 SV=1" "0.000" "False" "58.865" "22" "13" "16" "13" "782" "84.8" "5.57" "56.52" "13" "signal transduction" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf12796, Pf15898" "54776" "ENSG00000125503" "PPP1R12C" "B4DME2; hsa:54776; Q59FK8; Q6ZPD1; Q7L8F7; Q96HW1; Q9BZL4; Q9H5H5; Q9NT00" "" "Focal adhesion" "1" "0" "1.024" "1.027" "1.175" "1.169" "1.092" "1.143" "1.081" "1.080" "1.122" "1033.7" "1058.7" "1062.1" "1214.2" "1208.0" "1128.3" "1181.9" "1116.9" "1116.3" "1160.3" "" "" "" "" "" "" "" "" "" "" "830.2" "763.9" "843.6" "813.5" "835.5" "846.5" "827.5" "815.7" "1116.3" "943.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1376480877538073283" "False" "High" "IsMasterProtein" "Q14232" "Translation initiation factor eIF2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1" "0.000" "False" "58.862" "35" "12" "23" "12" "305" "33.7" "7.33" "72.12" "12" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "1967" "ENSG00000111361" "EIF2B1" "A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4" "Recycling of eIF2:GDP" "Translation factors" "2" "0" "1.023" "1.013" "1.004" "1.032" "0.985" "1.004" "1.030" "0.956" "0.999" "2318.1" "2371.3" "2348.8" "2327.8" "2392.3" "2284.2" "2327.3" "2386.9" "2215.9" "2316.5" "" "" "" "" "" "" "" "" "" "" "1861.8" "1711.1" "1865.8" "1559.6" "1654.5" "1713.8" "1629.4" "1743.1" "2215.9" "1883.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653311583040189549" "False" "High" "IsMasterProtein" "Q9H2P9" "Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2" "0.000" "False" "58.851" "35" "9" "12" "9" "285" "31.6" "5.31" "46.91" "9" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00590" "51611" "ENSG00000117543" "DPH5" "A8JZY6; D3DT62; hsa:51611; Q9H2P9; Q9P017; Q9P0I4; Q9Y319" "Synthesis of diphthamide-EEF2" "" "1" "0" "0.983" "0.996" "1.003" "1.036" "1.005" "0.925" "0.925" "0.975" "0.965" "1183.7" "1163.5" "1179.1" "1187.3" "1225.7" "1189.3" "1094.9" "1095.4" "1154.6" "1142.5" "" "" "" "" "" "" "" "" "" "" "950.7" "839.6" "936.6" "795.5" "847.7" "892.3" "766.6" "800.0" "1154.6" "929.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449077897622524501" "False" "High" "IsMasterProtein" "O95551" "Tyrosyl-DNA phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=TDP2 PE=1 SV=1" "0.000" "False" "58.797" "24" "7" "15" "7" "362" "40.9" "5.10" "59.86" "7" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf14555" "51567" "ENSG00000111802" "TDP2" "B4DKL8; B4DQ95; O95551; Q2TBE2; Q5JYM0; Q7Z6U5; Q9NUK5; Q9NYY9" "Nonhomologous End-Joining (NHEJ)" "Oxidative damage response" "2" "0" "1.084" "1.032" "1.083" "1.015" "1.004" "1.015" "1.014" "1.068" "1.018" "1038.8" "1126.5" "1072.0" "1125.3" "1054.7" "1043.3" "1053.9" "1052.9" "1109.5" "1057.1" "" "" "" "" "" "" "" "" "" "" "834.4" "812.8" "851.6" "753.9" "729.4" "782.8" "737.9" "768.9" "1109.5" "859.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7804593392060362224" "False" "High" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "0.000" "False" "58.757" "16" "6" "20" "6" "419" "48.2" "6.15" "75.07" "6" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "9" "0" "0.982" "0.981" "0.905" "0.905" "0.963" "0.915" "0.912" "0.967" "0.952" "1334.3" "1309.9" "1308.3" "1206.9" "1207.3" "1284.3" "1221.1" "1217.4" "1290.2" "1269.7" "" "" "" "" "" "" "" "" "" "" "1071.7" "945.2" "1039.3" "808.6" "835.0" "963.6" "855.0" "889.1" "1290.2" "1032.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2028658389890867927" "False" "High" "IsMasterProtein" "Q99708" "DNA endonuclease RBBP8 OS=Homo sapiens OX=9606 GN=RBBP8 PE=1 SV=2" "0.000" "False" "58.756" "14" "13" "15" "13" "897" "101.9" "6.30" "49.56" "13" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08573, Pf10482" "5932" "ENSG00000101773" "RBBP8" "A6NKN2; A8K8W6; E7ETY1; hsa:5932; O75371; Q8NHQ3; Q99708" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; Transcriptional Regulation by E2F6; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; HDR through MMEJ (alt-NHEJ)" "ATM signaling in development and disease" "18" "0" "1.024" "1.025" "1.058" "1.037" "0.981" "1.198" "1.311" "1.304" "1.100" "1058.0" "1083.7" "1084.6" "1119.8" "1096.6" "1037.8" "1267.4" "1387.5" "1379.3" "1163.5" "" "" "" "" "" "" "" "" "" "" "849.8" "781.9" "861.5" "750.2" "758.4" "778.6" "887.4" "1013.3" "1379.3" "946.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174444924925407144" "False" "High" "IsMasterProtein" "P61088" "Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1" "0.000" "False" "58.732" "55" "8" "34" "8" "152" "17.1" "6.57" "108.89" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7334" "ENSG00000177889" "UBE2N" "hsa:7334; P61088; Q16781; Q53Y81" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; Prader-Willi and Angelman syndrome; 3q29 copy number variation syndrome" "28" "0" "1.030" "1.024" "0.983" "1.086" "1.047" "1.095" "1.036" "1.097" "1.007" "2394.0" "2464.7" "2452.4" "2352.8" "2599.1" "2505.8" "2620.8" "2480.2" "2626.8" "2410.2" "" "" "" "" "" "" "" "" "" "" "1922.8" "1778.5" "1948.0" "1576.4" "1797.5" "1880.1" "1835.0" "1811.3" "2626.8" "1960.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544092344489090561" "False" "High" "IsMasterProtein" "Q8TB72" "Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2" "0.000" "False" "58.695" "11" "11" "13" "8" "1066" "114.1" "7.08" "53.52" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "23369" "ENSG00000055917" "PUM2" "B3KSL0; B4E2B6; D6W527; hsa:23369; O00234; Q53TV7; Q8TB72; Q8WY43; Q9HAN2" "Neddylation" "Male infertility" "2" "0" "1.007" "1.014" "1.002" "1.032" "0.970" "0.974" "1.057" "0.967" "0.995" "811.4" "817.0" "822.7" "812.9" "837.7" "786.8" "790.7" "857.3" "784.4" "807.4" "" "" "" "" "" "" "" "" "" "" "651.7" "589.6" "653.5" "544.6" "579.4" "590.3" "553.6" "626.1" "784.4" "656.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8207864549745438201" "False" "High" "IsMasterProtein" "Q96T76" "MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2" "0.000" "False" "58.659" "14" "13" "17" "13" "1030" "113.2" "6.35" "52.07" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12460, Pf14500" "64210" "ENSG00000155229" "MMS19" "B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2; hsa:64210; Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; Q96DF1; Q96MR1; Q96RK5; Q96SK1; Q96T76; Q9BUE2; Q9BYS9" "Cytosolic iron-sulfur cluster assembly" "2q11.2 copy number variation syndrome" "2" "0" "1.029" "1.018" "1.062" "1.055" "0.988" "0.943" "1.045" "0.968" "1.025" "780.5" "802.8" "794.4" "829.0" "823.1" "771.4" "736.3" "815.9" "755.7" "799.8" "" "" "" "" "" "" "" "" "" "" "626.9" "579.3" "631.0" "555.5" "569.3" "578.8" "515.6" "595.9" "755.7" "650.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200038646673232615" "False" "High" "IsMasterProtein" "Q9P287" "BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1" "0.000" "False" "58.655" "32" "9" "15" "9" "314" "36.0" "4.61" "54.16" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;cytoskeletal activity" "Pf13862" "56647" "ENSG00000107949" "BCCIP" "B3KP45; hsa:56647; Q8ND15; Q96GC4; Q9P287; Q9P288" "" "" "0" "0" "1.053" "1.016" "1.108" "1.030" "1.036" "1.041" "1.038" "1.072" "1.122" "1253.9" "1320.1" "1274.1" "1388.9" "1292.0" "1299.1" "1304.9" "1302.0" "1344.1" "1407.0" "" "" "" "" "" "" "" "" "" "" "1007.1" "952.6" "1012.0" "930.5" "893.6" "974.7" "913.6" "950.8" "1344.1" "1144.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5315083588279200367" "False" "High" "IsMasterProtein" "Q96FZ2" "Abasic site processing protein HMCES OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1" "0.000" "False" "58.648" "35" "11" "19" "11" "354" "40.5" "8.15" "64.43" "11" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf02586" "56941" "ENSG00000183624" "HMCES" "A6NJR9; hsa:56941; Q96FZ2; Q96G34; Q9NRP3" "" "" "0" "0" "1.034" "1.009" "0.961" "0.976" "0.981" "0.851" "0.936" "0.947" "0.991" "1854.4" "1917.3" "1870.2" "1782.7" "1810.5" "1819.8" "1578.5" "1736.4" "1756.0" "1838.0" "" "" "" "" "" "" "" "" "" "" "1489.4" "1383.5" "1485.5" "1194.4" "1252.1" "1365.4" "1105.2" "1268.1" "1756.0" "1494.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8984223167418137130" "False" "High" "IsMasterProtein" "P62633" "CCHC-type zinc finger nucleic acid binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "0.000" "False" "58.595" "50" "8" "20" "8" "177" "19.5" "7.71" "61.27" "8" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "0" "1.021" "1.006" "0.860" "0.953" "1.099" "1.006" "0.995" "0.973" "0.965" "1179.3" "1204.3" "1186.3" "1014.2" "1123.8" "1295.9" "1186.6" "1172.9" "1147.4" "1138.2" "" "" "" "" "" "" "" "" "" "" "947.2" "869.0" "942.3" "679.5" "777.3" "972.3" "830.8" "856.6" "1147.4" "925.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-81494833362564834" "False" "High" "IsMasterProtein" "Q8WVJ2" "NudC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NUDCD2 PE=1 SV=1" "0.000" "False" "58.583" "41" "5" "11" "5" "157" "17.7" "5.07" "43.20" "5" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04969" "134492" "ENSG00000170584" "NUDCD2" "B2R4V0; hsa:134492; Q8WVJ2" "" "" "0" "0" "0.991" "1.031" "0.966" "0.996" "1.027" "0.972" "0.982" "0.985" "1.018" "1253.1" "1242.4" "1291.6" "1210.1" "1248.6" "1287.1" "1218.1" "1230.0" "1234.3" "1275.1" "" "" "" "" "" "" "" "" "" "" "1006.5" "896.5" "1025.9" "810.7" "863.5" "965.7" "852.8" "898.3" "1234.3" "1037.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664537344047956195" "False" "High" "IsMasterProtein" "Q08209" "Protein phosphatase 3 catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "0.000" "False" "58.553" "23" "11" "25" "6" "521" "58.7" "5.86" "71.29" "11" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Ca2+ pathway; Calcineurin activates NFAT; DARPP-32 events" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "26" "4" "0.996" "0.982" "0.995" "0.992" "0.981" "0.917" "0.956" "0.987" "0.960" "2091.8" "2084.1" "2055.0" "2081.6" "2075.1" "2052.3" "1918.7" "1999.3" "2063.9" "2008.9" "" "" "" "" "" "" "" "" "" "" "1680.1" "1503.9" "1632.4" "1394.7" "1435.2" "1539.8" "1343.4" "1460.1" "2063.9" "1633.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222501069186758979" "False" "High" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "0.000" "False" "58.550" "36" "8" "10" "8" "341" "37.5" "7.43" "44.22" "8" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "1.050" "1.063" "1.084" "1.150" "1.048" "1.034" "1.037" "1.017" "1.097" "736.1" "772.6" "782.4" "798.1" "846.7" "771.2" "761.3" "763.0" "748.7" "807.3" "" "" "" "" "" "" "" "" "" "" "591.2" "557.5" "621.5" "534.7" "585.6" "578.6" "533.0" "557.2" "748.7" "656.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8827666052570193854" "False" "High" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "0.000" "False" "58.531" "44" "8" "32" "8" "248" "27.4" "7.23" "104.09" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "Translation factors; 7q11.23 copy number variation syndrome" "7" "0" "1.038" "1.054" "1.125" "1.085" "1.156" "1.077" "1.075" "1.133" "1.125" "1953.4" "2026.7" "2059.7" "2197.3" "2119.7" "2258.3" "2102.9" "2100.3" "2212.3" "2198.3" "" "" "" "" "" "" "" "" "" "" "1568.9" "1462.4" "1636.1" "1472.2" "1466.0" "1694.4" "1472.4" "1533.8" "2212.3" "1787.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5631363744109016659" "False" "High" "IsMasterProtein" "Cont_Q04695" "Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2" "0.000" "True" "58.495" "22" "12" "18" "2" "432" "48.1" "5.02" "56.87" "12" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton" "other molecular function" "Pf00038" "3872" "ENSCABG00000017365; ENSG00000128422" "KRT17" "A0A8C0IX11; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2; hsa:3872; Q04695; Q6IP98; Q8N1P6" "Formation of the cornified envelope" "1p36 copy number variation syndrome; Pancreatic cancer subtypes" "4" "0" "0.274" "0.052" "0.148" "0.123" "0.120" "0.230" "0.070" "0.212" "0.252" "1721.9" "471.9" "90.0" "255.3" "212.6" "207.2" "396.0" "119.8" "364.3" "434.0" "" "" "" "" "" "" "" "" "" "" "1383.0" "340.5" "71.5" "171.1" "147.0" "155.4" "277.2" "87.5" "364.3" "353.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6782447041087316008" "False" "High" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "0.000" "False" "58.484" "29" "12" "26" "12" "486" "55.7" "5.20" "79.53" "12" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "Clathrin-mediated endocytosis" "" "1" "0" "0.990" "0.970" "1.009" "1.001" "1.009" "1.013" "0.976" "0.979" "0.995" "2315.9" "2293.5" "2247.0" "2336.5" "2317.2" "2337.4" "2346.8" "2261.4" "2267.9" "2305.4" "" "" "" "" "" "" "" "" "" "" "1860.1" "1654.9" "1784.9" "1565.4" "1602.6" "1753.7" "1643.1" "1651.5" "2267.9" "1874.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-496325283526098650" "False" "High" "IsMasterProtein" "O75427" "Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LRCH4 PE=1 SV=2" "0.000" "False" "58.465" "17" "7" "10" "7" "683" "73.4" "8.22" "41.59" "7" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "" "Pf00307, Pf13855" "4034" "ENSG00000077454" "LRCH4" "A4D2D5; hsa:4034; O75427; Q8WV85; Q96ID0" "" "" "0" "0" "1.094" "1.005" "1.050" "1.036" "1.020" "1.016" "1.104" "1.060" "1.056" "394.5" "431.4" "396.5" "414.2" "408.7" "402.3" "400.9" "435.5" "418.2" "416.5" "" "" "" "" "" "" "" "" "" "" "316.9" "311.3" "314.9" "277.5" "282.7" "301.9" "280.7" "318.1" "418.2" "338.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1466786555444396810" "False" "High" "IsMasterProtein" "Q12933" "TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2" "0.000" "False" "58.452" "24" "13" "23" "13" "501" "55.8" "7.53" "64.37" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf16673, Pf21341, Pf21355" "7186" "ENSG00000127191" "TRAF2" "A8K107; B4DPJ7; hsa:7186; Q12933; Q7Z337; Q96NT2" "Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TRAF6 mediated NF-kB activation; Regulation of NF-kappa B signaling; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; 13q12.12 copy number variation; 8q11.23 (RB1CC1) copy number variation" "37" "0" "1.008" "0.971" "1.002" "0.961" "0.936" "1.049" "1.019" "0.973" "0.990" "1206.3" "1215.7" "1171.1" "1208.6" "1159.4" "1129.5" "1265.2" "1228.7" "1173.9" "1194.5" "" "" "" "" "" "" "" "" "" "" "968.9" "877.2" "930.3" "809.7" "801.9" "847.4" "885.9" "897.3" "1173.9" "971.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6956886752181187117" "False" "High" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "0.000" "False" "58.440" "38" "13" "18" "12" "364" "40.7" "8.88" "56.59" "13" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "Protein hydroxylation" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.034" "0.997" "1.075" "1.023" "0.977" "1.010" "1.055" "1.032" "1.089" "848.9" "877.9" "846.0" "912.4" "868.7" "829.1" "857.5" "895.7" "876.2" "924.4" "" "" "" "" "" "" "" "" "" "" "681.9" "633.5" "672.0" "611.3" "600.8" "622.0" "600.4" "654.2" "876.2" "751.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120276004969488072" "False" "High" "IsMasterProtein" "Q15080" "Neutrophil cytosol factor 4 OS=Homo sapiens OX=9606 GN=NCF4 PE=1 SV=2" "0.000" "False" "58.410" "37" "11" "17" "11" "339" "39.0" "6.83" "58.39" "11" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00564, Pf00787" "4689" "ENSG00000100365" "NCF4" "A8K4F9; hsa:4689; O60808; Q15080; Q86U56; Q9BU98; Q9NP45" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "11" "0" "1.022" "1.024" "1.007" "1.039" "1.048" "0.983" "1.069" "1.065" "1.029" "1080.4" "1103.8" "1106.0" "1087.6" "1122.8" "1132.2" "1062.0" "1155.2" "1150.8" "1111.2" "" "" "" "" "" "" "" "" "" "" "867.7" "796.5" "878.5" "728.7" "776.5" "849.4" "743.6" "843.6" "1150.8" "903.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058641913772226661" "False" "High" "IsMasterProtein" "Q68CJ6" "Nuclear GTPase SLIP-GC OS=Homo sapiens OX=9606 GN=NUGGC PE=1 SV=3" "0.000" "False" "58.391" "17" "14" "19" "13" "796" "91.1" "8.63" "57.17" "14" "other biological processes" "nucleus" "other molecular function" "Pf00350" "389643" "ENSG00000189233" "NUGGC" "hsa:389643; Q68CJ6; Q6ZP73" "" "" "0" "0" "1.029" "0.983" "1.150" "1.056" "0.899" "0.868" "0.752" "0.714" "0.935" "1871.4" "1925.0" "1839.3" "2151.7" "1976.1" "1683.1" "1624.0" "1407.5" "1336.1" "1750.6" "" "" "" "" "" "" "" "" "" "" "1503.1" "1389.0" "1461.0" "1441.6" "1366.7" "1262.8" "1137.0" "1027.9" "1336.1" "1423.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4732323992224053242" "False" "High" "IsMasterProtein" "Q9NU22" "Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2" "0.000" "False" "58.373" "4" "17" "18" "17" "5596" "632.4" "5.68" "41.93" "17" "cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07728, Pf17865, Pf17867, Pf21108" "23195" "ENSG00000112159" "MDN1" "hsa:23195; O15019; Q5T794; Q9NU22" "" "" "0" "0" "0.988" "1.063" "1.048" "0.982" "0.997" "0.964" "0.996" "0.995" "1.013" "1116.7" "1103.3" "1186.9" "1169.9" "1096.4" "1113.2" "1076.9" "1112.3" "1110.7" "1131.6" "" "" "" "" "" "" "" "" "" "" "896.9" "796.1" "942.8" "783.8" "758.3" "835.2" "754.0" "812.3" "1110.7" "920.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4683582367495080514" "False" "High" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "0.000" "False" "58.328" "16" "12" "16" "12" "826" "92.4" "5.96" "54.39" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "HATs acetylate histones" "" "1" "0" "0.972" "0.973" "1.004" "0.997" "0.959" "0.967" "0.958" "0.921" "0.972" "1244.5" "1209.4" "1210.5" "1249.3" "1240.9" "1193.1" "1203.2" "1191.9" "1145.9" "1209.8" "" "" "" "" "" "" "" "" "" "" "999.5" "872.7" "961.5" "837.0" "858.2" "895.2" "842.4" "870.4" "1145.9" "983.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2253036871243965201" "False" "High" "IsMasterProtein" "Q15014" "Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1" "0.000" "False" "58.328" "27" "7" "13" "5" "288" "32.3" "9.72" "46.83" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf05712" "9643" "ENSG00000123562" "MORF4L2" "B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026" "HATs acetylate histones" "" "1" "0" "1.005" "0.974" "1.094" "1.058" "1.019" "0.957" "0.937" "1.037" "1.048" "392.3" "394.3" "382.2" "429.1" "415.2" "399.8" "375.6" "367.7" "406.8" "411.3" "" "" "" "" "" "" "" "" "" "" "315.1" "284.5" "303.6" "287.5" "287.2" "299.9" "263.0" "268.5" "406.8" "334.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711060710327679778" "False" "High" "IsMasterProtein" "O75886" "Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1" "0.000" "False" "58.321" "14" "7" "14" "6" "525" "58.1" "5.07" "49.53" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "10254" "ENSG00000115145" "STAM2" "A8K8A0; D3DPA1; hsa:10254; O75886; Q7LDQ0; Q9UF58" "Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "EGF/EGFR signaling pathway" "9" "0" "1.047" "0.953" "0.944" "0.951" "0.946" "0.937" "0.952" "0.987" "0.946" "1020.9" "1069.3" "972.7" "963.3" "970.5" "965.6" "957.0" "971.5" "1007.1" "965.7" "" "" "" "" "" "" "" "" "" "" "820.0" "771.6" "772.7" "645.4" "671.2" "724.5" "670.0" "709.5" "1007.1" "785.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4465536822655971344" "False" "High" "IsMasterProtein" "Q9UPU7" "TBC1 domain family member 2B OS=Homo sapiens OX=9606 GN=TBC1D2B PE=1 SV=2" "0.000" "False" "58.320" "15" "12" "13" "12" "963" "109.8" "6.16" "40.29" "12" "transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00169, Pf00566" "23102" "ENSG00000167202" "TBC1D2B" "A7MD42; hsa:23102; Q8N1F9; Q9NXM0; Q9UPU7" "" "" "0" "0" "0.965" "0.966" "0.957" "0.932" "0.945" "1.009" "0.996" "1.001" "0.924" "699.5" "675.1" "675.7" "669.1" "652.3" "661.0" "705.5" "697.0" "700.2" "646.5" "" "" "" "" "" "" "" "" "" "" "561.8" "487.2" "536.7" "448.3" "451.1" "495.9" "494.0" "509.0" "700.2" "525.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243643898250283401" "False" "High" "IsMasterProtein" "Q9UI08" "Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=EVL PE=1 SV=2" "0.000" "False" "58.280" "34" "12" "20" "11" "416" "44.6" "8.84" "59.56" "12" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "51466" "ENSG00000196405" "EVL" "A8K105; B7Z3I5; hsa:51466; O95884; Q7Z522; Q8TBV1; Q9UF25; Q9UI08; Q9UIC2" "Generation of second messenger molecules; RHO GTPases Activate Formins; Signaling by ROBO receptors" "" "3" "1" "0.948" "0.937" "0.970" "1.004" "1.026" "0.958" "0.944" "0.949" "0.993" "1555.7" "1474.8" "1458.2" "1509.0" "1562.6" "1596.3" "1491.0" "1469.0" "1476.5" "1544.7" "" "" "" "" "" "" "" "" "" "" "1249.5" "1064.2" "1158.3" "1011.0" "1080.7" "1197.7" "1043.9" "1072.8" "1476.5" "1256.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1430598846084428850" "False" "High" "IsMasterProtein" "Q3B726" "DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=POLR1F PE=1 SV=1" "0.000" "False" "58.259" "21" "5" "9" "5" "338" "37.4" "6.98" "41.47" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf03876, Pf17875" "221830" "ENSG00000105849" "POLR1F" "A0PJ45; B7Z724; hsa:221830; Q3B726" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "7" "0" "0.993" "1.028" "0.896" "0.918" "0.979" "0.917" "1.000" "0.996" "1.005" "1111.4" "1103.4" "1142.9" "995.6" "1019.8" "1087.8" "1019.0" "1110.9" "1107.0" "1116.6" "" "" "" "" "" "" "" "" "" "" "892.6" "796.2" "907.9" "667.0" "705.3" "816.2" "713.5" "811.3" "1107.0" "908.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8476150003951297336" "False" "High" "IsMasterProtein" "Q96KG9" "N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1" "0.000" "False" "58.243" "15" "10" "14" "10" "808" "89.6" "6.30" "48.20" "10" "stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "57410" "ENSG00000142186" "SCYL1" "A6NJF1; hsa:57410; Q96G50; Q96KG8; Q96KG9; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53" "" "" "0" "0" "1.045" "0.995" "0.989" "0.986" "0.938" "0.906" "1.031" "1.025" "0.997" "1070.5" "1119.1" "1065.1" "1058.5" "1055.8" "1003.8" "969.6" "1104.1" "1097.7" "1067.4" "" "" "" "" "" "" "" "" "" "" "859.8" "807.5" "846.1" "709.2" "730.2" "753.1" "678.8" "806.3" "1097.7" "868.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3792046426100688845" "False" "High" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "0.000" "False" "58.204" "18" "12" "19" "12" "683" "77.5" "9.50" "56.08" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.060" "1.046" "1.048" "1.059" "1.051" "1.016" "1.085" "1.038" "1.031" "2175.9" "2306.6" "2275.8" "2281.4" "2304.3" "2286.8" "2210.0" "2359.8" "2258.6" "2243.6" "" "" "" "" "" "" "" "" "" "" "1747.7" "1664.4" "1807.8" "1528.5" "1593.7" "1715.7" "1547.3" "1723.4" "2258.6" "1824.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2034922387344060046" "False" "High" "IsMasterProtein" "P12955" "Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3" "0.000" "False" "58.077" "24" "11" "14" "11" "493" "54.5" "6.00" "51.28" "11" "protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00557, Pf05195" "5184" "ENSG00000124299" "PEPD" "A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8; hsa:5184; P12955; Q8TBN9; Q9BT75" "" "" "0" "0" "1.028" "1.000" "1.050" "0.929" "0.964" "0.878" "0.747" "0.878" "0.936" "1032.9" "1061.9" "1032.5" "1084.3" "959.6" "995.7" "907.3" "772.1" "907.3" "967.3" "" "" "" "" "" "" "" "" "" "" "829.6" "766.2" "820.1" "726.4" "663.7" "747.1" "635.2" "563.8" "907.3" "786.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4946696058487786946" "False" "High" "IsMasterProtein" "Q9UHJ6" "Sedoheptulokinase OS=Homo sapiens OX=9606 GN=SHPK PE=1 SV=4" "0.000" "False" "58.017" "25" "8" "12" "8" "478" "51.5" "6.83" "55.05" "8" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00370" "23729" "ENSG00000197417" "SHPK" "B2R640; Q8WUH3; Q9UHJ6" "Pentose phosphate pathway" "" "1" "0" "1.070" "1.047" "1.160" "1.133" "1.089" "1.119" "1.038" "1.092" "1.130" "720.5" "770.9" "754.3" "835.8" "816.4" "784.4" "806.4" "748.0" "787.2" "814.4" "" "" "" "" "" "" "" "" "" "" "578.7" "556.2" "599.2" "560.0" "564.6" "588.5" "564.6" "546.2" "787.2" "662.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697367026041443041" "False" "High" "IsMasterProtein" "Q96A49" "Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1" "0.000" "False" "57.955" "20" "6" "13" "6" "352" "39.9" "4.53" "46.74" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03909" "94056" "ENSG00000169895" "SYAP1" "hsa:94056; Q68CP1; Q96A49; Q96C60; Q96JQ6; Q96T20" "" "" "0" "0" "1.030" "1.003" "1.048" "1.011" "0.982" "0.965" "1.046" "0.995" "0.995" "1055.2" "1087.3" "1058.6" "1105.5" "1066.6" "1035.9" "1018.3" "1104.1" "1050.3" "1050.4" "" "" "" "" "" "" "" "" "" "" "847.5" "784.6" "840.9" "740.7" "737.7" "777.2" "713.0" "806.3" "1050.3" "854.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8106811875095759613" "False" "High" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "0.000" "False" "57.907" "23" "5" "59" "5" "111" "12.2" "3.78" "190.45" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.990" "0.976" "0.937" "0.885" "0.960" "0.884" "0.912" "0.913" "0.944" "4443.4" "4399.5" "4337.2" "4165.0" "3931.5" "4263.8" "3928.5" "4053.9" "4057.9" "4194.6" "" "" "" "" "" "" "" "" "" "" "3568.9" "3174.6" "3445.2" "2790.5" "2719.1" "3199.1" "2750.6" "2960.5" "4057.9" "3411.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7253720687934924150" "False" "High" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "0.000" "False" "57.893" "22" "9" "15" "9" "551" "62.1" "8.40" "50.39" "9" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "ISG15 antiviral mechanism; PKR-mediated signaling; Interferon alpha/beta signaling; Evasion by RSV of host interferon responses; Inhibition of PKR; SUMOylation of immune response proteins" "Translation factors; Alzheimer's disease and miRNA effects; PDGFR-beta pathway; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "16" "0" "1.097" "1.053" "1.023" "1.035" "1.102" "1.029" "1.115" "1.077" "1.085" "831.5" "911.8" "875.3" "851.0" "860.6" "916.1" "855.7" "927.1" "895.3" "902.3" "" "" "" "" "" "" "" "" "" "" "667.8" "657.9" "695.3" "570.2" "595.2" "687.3" "599.1" "677.0" "895.3" "733.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8881976693439910842" "False" "High" "IsMasterProtein" "P40306" "Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1" "0.000" "False" "57.805" "31" "7" "10" "7" "273" "28.9" "7.81" "43.71" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5699" "ENSG00000205220" "PSMB10" "B2R5J4; hsa:5699; P40306; Q5U098" "Regulation of PTEN stability and activity; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of RAS by GAPs; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "0.994" "0.963" "0.924" "0.913" "0.996" "0.915" "0.941" "0.964" "0.965" "966.3" "960.8" "930.8" "893.1" "882.3" "962.7" "884.6" "909.5" "931.1" "932.2" "" "" "" "" "" "" "" "" "" "" "776.1" "693.3" "739.3" "598.4" "610.2" "722.3" "619.4" "664.2" "931.1" "758.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318017384069718868" "False" "High" "IsMasterProtein" "Q9Y5B0" "RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3" "0.000" "False" "57.786" "16" "15" "19" "15" "961" "104.3" "5.27" "58.46" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00533, Pf03031, Pf09309" "9150" "ENSG00000060069" "CTDP1" "A8MY97; hsa:9150; Q7Z644; Q96BZ1; Q9Y5B0; Q9Y6F5" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "" "14" "0" "0.971" "1.026" "1.003" "0.941" "1.031" "0.938" "0.969" "0.971" "0.988" "633.7" "615.3" "649.9" "635.3" "596.1" "653.2" "594.2" "614.0" "615.4" "625.8" "" "" "" "" "" "" "" "" "" "" "509.0" "444.0" "516.3" "425.7" "412.3" "490.1" "416.1" "448.4" "615.4" "508.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1997849162023251854" "False" "High" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "0.000" "False" "57.594" "50" "6" "22" "6" "163" "18.6" "4.54" "61.12" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "39" "0" "1.064" "1.082" "1.002" "0.956" "1.047" "1.101" "1.074" "1.066" "1.005" "2054.5" "2185.4" "2224.0" "2059.6" "1963.6" "2151.5" "2262.4" "2206.9" "2190.4" "2064.5" "" "" "" "" "" "" "" "" "" "" "1650.2" "1576.9" "1766.6" "1379.9" "1358.1" "1614.3" "1584.0" "1611.7" "2190.4" "1678.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5375173174660804131" "False" "High" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "0.000" "False" "57.581" "24" "6" "9" "6" "335" "36.0" "9.28" "38.75" "6" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Omega-6-fatty acids in senescence" "5" "0" "0.981" "0.978" "0.988" "0.998" "0.952" "0.902" "0.865" "0.887" "0.975" "873.0" "856.3" "854.2" "862.5" "871.2" "831.1" "787.6" "755.4" "774.5" "851.6" "" "" "" "" "" "" "" "" "" "" "701.2" "617.8" "678.5" "577.9" "602.5" "623.5" "551.4" "551.7" "774.5" "692.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8447148284608472051" "False" "High" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "0.000" "False" "57.507" "33" "7" "11" "7" "224" "24.9" "4.82" "51.42" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "1.063" "0.988" "1.016" "1.066" "1.124" "1.135" "1.165" "1.068" "1.075" "1347.0" "1432.2" "1330.6" "1368.8" "1435.7" "1514.4" "1528.9" "1569.5" "1439.1" "1448.1" "" "" "" "" "" "" "" "" "" "" "1081.9" "1033.5" "1056.9" "917.1" "992.9" "1136.2" "1070.5" "1146.2" "1439.1" "1177.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3353134017530951509" "False" "High" "IsMasterProtein" "Q9Y5K5" "Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5 PE=1 SV=3" "0.000" "False" "57.477" "29" "9" "23" "9" "329" "37.6" "5.33" "73.00" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01088, Pf18031" "51377" "ENSG00000116750" "UCHL5" "hsa:51377; Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2; Q9Y5K5" "UCH proteinases; Downregulation of TGF-beta receptor signaling" "TGF-beta signaling pathway" "3" "0" "0.989" "0.943" "1.037" "0.984" "0.940" "0.962" "0.961" "0.932" "0.984" "2558.3" "2530.0" "2412.4" "2653.0" "2517.9" "2406.0" "2461.7" "2457.3" "2383.4" "2517.6" "" "" "" "" "" "" "" "" "" "" "2054.8" "1825.6" "1916.2" "1777.5" "1741.4" "1805.2" "1723.6" "1794.6" "2383.4" "2047.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4014732936272449079" "False" "High" "IsMasterProtein" "Q53EL6" "Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2" "0.000" "False" "57.461" "31" "10" "12" "10" "469" "51.7" "5.21" "45.87" "10" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02847" "27250" "ENSG00000150593" "PDCD4" "B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Translation inhibitors in chronically activated PDGFRA cells; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "4" "0" "0.883" "0.946" "1.047" "1.070" "1.116" "0.968" "0.792" "0.873" "0.993" "774.9" "684.3" "733.3" "811.0" "828.9" "864.5" "750.2" "613.8" "676.8" "769.4" "" "" "" "" "" "" "" "" "" "" "622.4" "493.8" "582.5" "543.4" "573.3" "648.6" "525.2" "448.3" "676.8" "625.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "741210737454912212" "False" "High" "IsMasterProtein" "Q7Z7A4" "PX domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=PXK PE=1 SV=1" "0.000" "False" "57.448" "18" "10" "15" "10" "578" "64.9" "9.35" "51.84" "10" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf02205" "54899" "ENSG00000168297" "PXK" "hsa:54899; Q3BCH4; Q3BCH5; Q3BCH6; Q3BDW1; Q45L83; Q59EX3; Q6PK17; Q6ZN39; Q7Z7A4; Q96CA3; Q96R07; Q9NXB8" "" "" "0" "0" "0.972" "0.985" "0.903" "0.944" "0.990" "0.891" "0.890" "0.865" "0.915" "970.1" "943.0" "955.4" "876.0" "915.9" "960.8" "864.8" "863.3" "839.3" "887.6" "" "" "" "" "" "" "" "" "" "" "779.2" "680.5" "758.9" "586.9" "633.5" "720.9" "605.5" "630.5" "839.3" "721.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-204711257539491149" "False" "High" "IsMasterProtein" "O96017" "Serine/threonine-protein kinase Chk2 OS=Homo sapiens OX=9606 GN=CHEK2 PE=1 SV=1" "0.000" "False" "57.414" "19" "9" "15" "9" "543" "60.9" "5.91" "43.91" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00498" "11200" "ENSG00000183765" "CHEK2" "A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5; hsa:11200; O96017; Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; Q6QA11; Q6QA12; Q6QA13; Q9HBS5; Q9HCQ8; Q9UGF0; Q9UGF1" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response" "13" "0" "1.010" "1.128" "1.002" "1.050" "1.026" "1.008" "1.044" "1.006" "1.002" "859.1" "868.1" "968.7" "861.2" "901.6" "881.7" "866.3" "896.9" "864.0" "860.8" "" "" "" "" "" "" "" "" "" "" "690.0" "626.4" "769.5" "577.0" "623.6" "661.5" "606.5" "655.0" "864.0" "700.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819630258189506626" "False" "High" "IsMasterProtein" "P02792" "Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2" "0.000" "False" "57.360" "50" "7" "11" "7" "175" "20.0" "5.78" "48.73" "7" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2512" "ENSG00000087086" "FTL" "B2R4B9; hsa:2512; P02792; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "9" "0" "0.992" "1.007" "1.012" "0.980" "1.010" "1.011" "0.939" "0.917" "1.033" "1323.2" "1312.8" "1333.0" "1339.0" "1297.1" "1336.9" "1338.4" "1242.7" "1213.3" "1367.3" "" "" "" "" "" "" "" "" "" "" "1062.8" "947.3" "1058.8" "897.1" "897.1" "1003.1" "937.1" "907.6" "1213.3" "1112.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813799245873050122" "False" "High" "IsMasterProtein" "Q96L91" "E1A-binding protein p400 OS=Homo sapiens OX=9606 GN=EP400 PE=1 SV=4" "0.000" "False" "57.305" "5" "13" "13" "13" "3159" "343.3" "9.19" "43.40" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529, Pf15790" "57634" "ENSG00000183495" "EP400" "hsa:57634; O15411; Q6P2F5; Q8N8Q7; Q8NE05; Q96JK7; Q96L91; Q9P230" "HATs acetylate histones; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "HDAC6 interactions in the central nervous system" "4" "0" "1.014" "0.993" "1.006" "1.063" "0.988" "1.039" "1.066" "1.059" "1.022" "1753.5" "1778.6" "1741.9" "1764.7" "1863.8" "1733.2" "1821.3" "1868.6" "1856.8" "1792.4" "" "" "" "" "" "" "" "" "" "" "1408.4" "1283.4" "1383.7" "1182.4" "1289.0" "1300.4" "1275.1" "1364.6" "1856.8" "1457.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7310593134022698633" "False" "High" "IsMasterProtein" "P57081" "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2" "0.000" "False" "57.285" "34" "10" "16" "9" "412" "45.5" "7.11" "55.74" "10" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00400" "10785" "ENSG00000160193" "WDR4" "A8KA58; B2RCA3; B4DNQ7; D3DSK3; hsa:10785; P57081; Q9BVM5; Q9HCR3" "tRNA modification in the nucleus and cytosol" "" "1" "1" "1.018" "1.022" "0.986" "1.002" "0.975" "0.919" "0.986" "0.964" "1.009" "1542.3" "1570.2" "1576.8" "1521.3" "1545.3" "1503.5" "1416.8" "1521.5" "1487.4" "1555.6" "" "" "" "" "" "" "" "" "" "" "1238.8" "1133.0" "1252.5" "1019.3" "1068.7" "1128.0" "992.0" "1111.1" "1487.4" "1265.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "380147253527428052" "False" "High" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "0.000" "False" "57.230" "16" "8" "17" "6" "601" "63.8" "5.22" "60.97" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "0" "1.101" "1.057" "1.071" "1.125" "1.020" "1.078" "1.035" "1.081" "1.129" "385.9" "425.0" "408.1" "413.2" "434.3" "393.8" "416.0" "399.4" "417.0" "435.8" "" "" "" "" "" "" "" "" "" "" "310.0" "306.6" "324.1" "276.8" "300.4" "295.4" "291.2" "291.7" "417.0" "354.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444524107574200916" "False" "High" "IsMasterProtein" "Q9UH73" "Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2" "0.000" "False" "57.216" "20" "9" "13" "9" "591" "64.4" "8.76" "53.63" "9" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "1879" "ENSG00000164330" "EBF1" "hsa:1879; Q8IW11; Q9UH73" "Transcriptional regulation of white adipocyte differentiation; Expression and translocation of olfactory receptors" "Adipogenesis; Prion disease pathway; White fat cell differentiation" "5" "0" "0.995" "0.970" "0.991" "1.041" "0.937" "0.920" "0.967" "0.895" "0.991" "1169.4" "1163.8" "1133.8" "1158.4" "1217.5" "1096.2" "1075.6" "1130.3" "1046.1" "1159.3" "" "" "" "" "" "" "" "" "" "" "939.2" "839.8" "900.6" "776.1" "842.1" "822.4" "753.1" "825.4" "1046.1" "942.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198738028437086806" "False" "High" "IsMasterProtein" "Q7Z2W4" "Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3" "0.000" "False" "57.201" "16" "10" "10" "10" "902" "101.4" "8.40" "40.10" "10" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf02825, Pf18606, Pf18633" "56829" "ENSG00000105939" "ZC3HAV1" "A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "1.033" "0.982" "1.139" "1.031" "0.977" "1.156" "1.082" "1.060" "1.033" "766.9" "792.5" "753.3" "873.7" "790.6" "749.2" "886.4" "829.9" "813.3" "792.3" "" "" "" "" "" "" "" "" "" "" "616.0" "571.8" "598.4" "585.3" "546.8" "562.1" "620.6" "606.1" "813.3" "644.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407233124236787373" "False" "High" "IsMasterProtein" "Q96DB5" "Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1" "0.000" "False" "57.196" "35" "10" "16" "10" "314" "35.8" "8.50" "54.49" "10" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity" "Pf21033" "51115" "ENSG00000176623" "RMDN1" "A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; hsa:51115; Q96DB5; Q9Y398" "" "" "0" "0" "0.992" "1.006" "0.975" "0.979" "0.968" "0.959" "1.004" "0.963" "1.006" "1149.3" "1140.7" "1155.7" "1120.9" "1125.7" "1112.4" "1102.1" "1153.7" "1106.6" "1156.1" "" "" "" "" "" "" "" "" "" "" "923.1" "823.1" "918.0" "751.0" "778.6" "834.6" "771.6" "842.6" "1106.6" "940.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3138004166962983246" "False" "High" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "0.000" "False" "57.193" "31" "8" "27" "5" "251" "28.8" "4.06" "89.63" "8" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "0" "0.960" "0.953" "0.988" "0.892" "0.972" "1.003" "0.912" "0.900" "0.905" "1740.4" "1670.3" "1658.7" "1719.1" "1553.0" "1692.1" "1746.4" "1588.0" "1566.9" "1574.9" "" "" "" "" "" "" "" "" "" "" "1397.9" "1205.2" "1317.6" "1151.8" "1074.1" "1269.5" "1222.7" "1159.7" "1566.9" "1280.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9091705123101461009" "False" "High" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "0.000" "False" "57.188" "48" "4" "25" "4" "105" "11.7" "9.57" "92.22" "4" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "36" "0" "0.991" "1.044" "0.893" "0.923" "1.052" "0.847" "1.028" "0.990" "1.001" "2713.7" "2688.1" "2833.7" "2423.3" "2505.2" "2855.9" "2299.8" "2789.0" "2686.8" "2717.1" "" "" "" "" "" "" "" "" "" "" "2179.6" "1939.7" "2250.9" "1623.6" "1732.6" "2142.7" "1610.2" "2036.8" "2686.8" "2209.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240907950946080993" "False" "High" "IsMasterProtein" "Q9BV44" "tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "0.000" "False" "57.151" "22" "10" "16" "10" "507" "57.0" "6.37" "44.99" "10" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "0.962" "1.015" "0.973" "0.995" "0.981" "0.943" "0.937" "0.958" "1.002" "985.6" "948.6" "1000.8" "958.6" "980.7" "967.0" "929.5" "923.9" "944.1" "987.4" "" "" "" "" "" "" "" "" "" "" "791.7" "684.5" "795.0" "642.3" "678.3" "725.5" "650.8" "674.7" "944.1" "803.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559430331434459476" "False" "High" "IsMasterProtein" "O95630" "STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1" "0.000" "False" "57.144" "26" "10" "13" "10" "424" "48.0" "6.29" "46.78" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "10617" "ENSG00000124356" "STAMBP" "B5M0B6; D6W5H7; hsa:10617; O95630; Q3MJE7" "Metalloprotease DUBs" "EGF/EGFR signaling pathway" "2" "0" "1.002" "1.017" "1.014" "1.001" "0.988" "0.949" "0.961" "0.984" "1.000" "1353.2" "1356.1" "1376.2" "1372.5" "1355.2" "1336.7" "1284.8" "1300.8" "1332.1" "1352.7" "" "" "" "" "" "" "" "" "" "" "1086.9" "978.6" "1093.2" "919.6" "937.3" "1002.9" "899.5" "950.0" "1332.1" "1100.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629654953317171872" "False" "High" "IsMasterProtein" "Q68CP9" "AT-rich interactive domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ARID2 PE=1 SV=2" "0.000" "False" "57.019" "8" "14" "15" "14" "1835" "197.3" "7.42" "49.15" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf02257" "196528" "ENSG00000189079" "ARID2" "Q15KG9; Q5EB51; Q645I3; Q68CP9; Q6ZRY5; Q7Z3I5; Q86T28; Q96SJ6; Q9HCL5" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "" "2" "0" "1.110" "1.059" "1.091" "1.004" "1.047" "1.074" "1.138" "1.028" "1.066" "1082.1" "1200.8" "1146.3" "1180.9" "1086.1" "1132.5" "1162.1" "1231.9" "1112.2" "1153.3" "" "" "" "" "" "" "" "" "" "" "869.1" "866.5" "910.6" "791.2" "751.2" "849.7" "813.6" "899.7" "1112.2" "937.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502404100025205194" "False" "High" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "0.000" "False" "57.018" "21" "13" "18" "13" "592" "67.5" "4.60" "51.27" "13" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "15q11q13 copy number variation" "9" "0" "0.900" "0.890" "0.952" "0.961" "1.060" "0.970" "0.969" "1.040" "0.963" "2710.5" "2439.1" "2413.6" "2579.5" "2603.8" "2873.7" "2629.5" "2626.3" "2819.9" "2609.3" "" "" "" "" "" "" "" "" "" "" "2177.0" "1760.0" "1917.2" "1728.2" "1800.8" "2156.1" "1841.1" "1918.0" "2819.9" "2122.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235259727744776076" "False" "High" "IsMasterProtein" "Q7Z4W1" "L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2" "0.000" "False" "57.013" "47" "9" "17" "9" "244" "25.9" "8.10" "59.17" "9" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13561" "51181" "ENSG00000169738" "DCXR" "hsa:51181; Q7Z4W1; Q9BTZ3; Q9UHY9" "Formation of xylulose-5-phosphate; Essential pentosuria" "" "2" "0" "1.028" "1.094" "1.024" "1.039" "1.044" "0.986" "1.006" "1.074" "1.017" "1191.0" "1224.5" "1302.8" "1219.9" "1237.6" "1243.0" "1174.1" "1197.6" "1279.6" "1211.1" "" "" "" "" "" "" "" "" "" "" "956.6" "883.6" "1034.8" "817.3" "855.9" "932.6" "822.0" "874.6" "1279.6" "984.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5820221568948669859" "False" "High" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "0.000" "False" "56.947" "46" "9" "23" "9" "183" "20.9" "7.69" "66.94" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; TGF-beta receptor signaling activates SMADs" "" "5" "0" "1.053" "1.023" "0.954" "0.992" "0.989" "0.967" "1.008" "1.030" "0.984" "1932.0" "2033.8" "1977.1" "1843.5" "1916.2" "1910.0" "1868.0" "1947.9" "1990.7" "1901.4" "" "" "" "" "" "" "" "" "" "" "1551.7" "1467.5" "1570.5" "1235.1" "1325.3" "1433.1" "1307.9" "1422.6" "1990.7" "1546.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2633610480889665575" "False" "High" "IsMasterProtein" "O75608" "Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1" "0.000" "False" "56.930" "36" "6" "16" "6" "230" "24.7" "6.77" "52.08" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "10434" "ENSG00000120992" "LYPLA1" "hsa:10434; O43202; O75608; Q9UQF9" "RAS processing; eNOS activation" "" "2" "0" "1.009" "1.026" "0.988" "0.990" "0.981" "1.025" "1.012" "0.993" "0.949" "1450.0" "1462.7" "1487.1" "1432.5" "1435.7" "1423.0" "1485.6" "1468.1" "1439.7" "1375.5" "" "" "" "" "" "" "" "" "" "" "1164.6" "1055.4" "1181.3" "959.8" "993.0" "1067.7" "1040.2" "1072.1" "1439.7" "1118.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264991097181317635" "False" "High" "IsMasterProtein" "Q9NPF5" "DNA methyltransferase 1-associated protein 1 OS=Homo sapiens OX=9606 GN=DMAP1 PE=1 SV=1" "0.000" "False" "56.843" "19" "8" "12" "8" "467" "53.0" "9.50" "42.86" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05499, Pf16282" "55929" "ENSG00000178028" "DMAP1" "A8K001; D3DPY8; hsa:55929; Q0JSM4; Q5TG41; Q7Z3H7; Q9H0S8; Q9NPF5; Q9P2C2" "HATs acetylate histones" "" "1" "0" "1.020" "0.979" "1.024" "0.940" "0.921" "0.958" "0.897" "0.951" "0.960" "546.3" "557.1" "535.0" "559.5" "513.5" "503.0" "523.4" "490.0" "519.7" "524.6" "" "" "" "" "" "" "" "" "" "" "438.8" "402.0" "424.9" "374.8" "355.2" "377.4" "366.5" "357.8" "519.7" "426.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5638474282161267402" "False" "High" "IsMasterProtein" "Q969Z0" "FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1" "0.000" "False" "56.810" "17" "10" "13" "10" "631" "70.7" "7.42" "48.05" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "9238" "ENSG00000136270" "TBRG4" "A4D2L2; A4D2L3; D3DVL5; D3DVL6; hsa:9238; O14710; Q53GI8; Q8NDM4; Q969Z0; Q9BUC6; Q9Y2F6" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "" "1" "0" "1.085" "1.044" "0.993" "1.014" "0.991" "0.937" "1.016" "0.986" "1.016" "1118.1" "1212.6" "1167.7" "1109.8" "1133.8" "1108.4" "1047.2" "1135.5" "1101.9" "1135.5" "" "" "" "" "" "" "" "" "" "" "898.0" "875.0" "927.5" "743.6" "784.2" "831.6" "733.2" "829.2" "1101.9" "923.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-763212604296308746" "False" "High" "IsMasterProtein" "Q8IXH7" "Negative elongation factor C/D OS=Homo sapiens OX=9606 GN=NELFCD PE=1 SV=2" "0.000" "False" "56.797" "21" "9" "12" "9" "590" "66.2" "5.10" "48.20" "9" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04858" "51497" "ENSG00000101158" "NELFCD" "B4DE06; hsa:51497; Q8IXH7; Q9BYL2; Q9H405; Q9H888; Q9H8T3; Q9NVX5; Q9P029; Q9UGN1; Q9UGN2; Q9UGN3" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "16" "0" "1.044" "0.965" "1.071" "0.981" "0.991" "0.945" "0.998" "1.099" "1.097" "381.9" "398.5" "368.7" "408.9" "374.7" "378.6" "361.0" "381.0" "419.6" "419.0" "" "" "" "" "" "" "" "" "" "" "306.7" "287.6" "292.9" "274.0" "259.1" "284.1" "252.7" "278.2" "419.6" "340.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153241618277291639" "False" "High" "IsMasterProtein" "Q9ULK4" "Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2" "0.000" "False" "56.746" "8" "10" "14" "10" "1368" "156.4" "7.40" "53.91" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11573" "9439" "ENSG00000112282" "MED23" "B9TX55; hsa:9439; O95403; Q5JWT3; Q5JWT4; Q6P9H6; Q9H0J2; Q9NTT9; Q9NTU0; Q9ULK4; Q9Y5P7; Q9Y667" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.032" "0.979" "1.051" "1.032" "0.983" "0.991" "1.042" "1.055" "1.008" "1052.5" "1086.6" "1030.5" "1106.0" "1086.6" "1034.9" "1042.7" "1096.4" "1109.9" "1061.2" "" "" "" "" "" "" "" "" "" "" "845.4" "784.1" "818.6" "741.0" "751.5" "776.5" "730.0" "800.7" "1109.9" "863.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7680692845404357414" "False" "High" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "0.000" "False" "56.726" "37" "8" "19" "8" "196" "22.2" "5.57" "52.80" "8" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "0.958" "0.924" "0.896" "0.965" "0.980" "0.985" "0.982" "0.941" "0.967" "1121.5" "1074.2" "1036.8" "1005.5" "1082.1" "1098.7" "1104.4" "1101.2" "1055.3" "1084.0" "" "" "" "" "" "" "" "" "" "" "900.8" "775.1" "823.6" "673.7" "748.4" "824.3" "773.2" "804.2" "1055.3" "881.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "197200824509217859" "False" "High" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "0.000" "False" "56.706" "25" "12" "15" "12" "664" "72.6" "7.39" "57.82" "12" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "1.025" "1.041" "1.079" "1.044" "1.089" "1.079" "1.068" "1.084" "1.081" "1097.3" "1125.1" "1142.5" "1184.4" "1145.6" "1195.0" "1183.6" "1171.4" "1189.9" "1185.6" "" "" "" "" "" "" "" "" "" "" "881.3" "811.9" "907.5" "793.6" "792.3" "896.6" "828.7" "855.5" "1189.9" "964.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633988099481439098" "False" "High" "IsMasterProtein" "Q9Y5T5" "Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1" "0.000" "False" "56.641" "18" "14" "15" "14" "823" "93.5" "6.93" "44.35" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf00443, Pf02148" "10600" "ENSG00000156256; ENSG00000291527" "USP16" "A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9; hsa:10600; Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; Q9Y5T5" "Ub-specific processing proteases" "" "1" "0" "1.007" "1.025" "1.039" "1.018" "0.993" "0.978" "0.976" "1.008" "0.994" "1601.5" "1612.6" "1641.6" "1663.7" "1630.7" "1590.9" "1566.9" "1563.3" "1614.0" "1592.2" "" "" "" "" "" "" "" "" "" "" "1286.3" "1163.6" "1304.0" "1114.7" "1127.8" "1193.6" "1097.1" "1141.7" "1614.0" "1294.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106414634070186016" "False" "High" "IsMasterProtein" "Q8WVM8" "Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4" "0.000" "False" "56.599" "19" "11" "22" "11" "642" "72.3" "6.27" "65.67" "11" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00995" "23256" "ENSG00000092108" "SCFD1" "A8K2Z5; B7Z4U7; B7Z594; hsa:23256; O60754; O94990; Q7Z529; Q8WVM8; Q9BZI3; Q9UNL3; Q9Y6A8" "RHOA GTPase cycle; COPII-mediated vesicle transport" "" "2" "0" "1.017" "0.906" "1.003" "0.947" "0.946" "0.981" "1.006" "0.979" "0.961" "1987.0" "2021.6" "1800.6" "1993.6" "1881.0" "1879.9" "1950.1" "1998.8" "1944.7" "1910.0" "" "" "" "" "" "" "" "" "" "" "1596.0" "1458.8" "1430.2" "1335.7" "1300.9" "1410.5" "1365.4" "1459.8" "1944.7" "1553.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8205566320687520923" "False" "High" "IsMasterProtein" "Q9NSK0" "Kinesin light chain 4 OS=Homo sapiens OX=9606 GN=KLC4 PE=1 SV=3" "0.000" "False" "56.461" "21" "12" "16" "7" "619" "68.6" "6.18" "49.65" "12" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf13374, Pf13424" "89953" "ENSG00000137171" "KLC4" "B3KNY4; B3KPI3; B3KSQ3; B4DME9; hsa:89953; Q66K28; Q96EG6; Q9NSK0" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "6" "0" "0.976" "0.935" "0.963" "1.016" "1.022" "1.016" "1.004" "1.047" "1.026" "613.1" "598.1" "573.1" "590.3" "622.9" "626.7" "623.0" "615.6" "642.1" "628.7" "" "" "" "" "" "" "" "" "" "" "492.4" "431.6" "455.2" "395.5" "430.8" "470.2" "436.2" "449.6" "642.1" "511.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7337665348008384774" "False" "High" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "0.000" "False" "56.390" "17" "7" "12" "7" "494" "55.0" "7.12" "46.59" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "Formation of the active cofactor, UDP-glucuronate" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "3" "0" "1.040" "0.965" "1.008" "1.022" "1.007" "0.955" "1.021" "1.017" "1.043" "1204.5" "1253.0" "1162.6" "1214.0" "1231.1" "1212.8" "1149.9" "1229.4" "1225.2" "1255.7" "" "" "" "" "" "" "" "" "" "" "967.5" "904.1" "923.5" "813.4" "851.5" "909.9" "805.1" "897.8" "1225.2" "1021.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6657686065862137180" "False" "High" "IsMasterProtein" "Q9Y371" "Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1" "0.000" "False" "56.337" "28" "10" "14" "9" "365" "40.8" "6.04" "55.25" "10" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03114, Pf14604" "51100" "ENSG00000097033" "SH3GLB1" "B4E182; hsa:51100; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; Q9Y371" "" "Nanoparticle triggered autophagic cell death" "1" "1" "0.992" "0.967" "1.014" "0.944" "0.971" "0.987" "1.037" "0.997" "0.996" "1564.4" "1551.5" "1512.0" "1585.9" "1477.4" "1518.8" "1544.2" "1621.8" "1559.1" "1558.3" "" "" "" "" "" "" "" "" "" "" "1256.5" "1119.5" "1201.1" "1062.6" "1021.8" "1139.5" "1081.2" "1184.4" "1559.1" "1267.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6460055541994458794" "False" "High" "IsMasterProtein" "Q14019" "Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3" "0.000" "False" "56.254" "64" "10" "43" "10" "142" "15.9" "5.67" "144.79" "10" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "23406" "ENSG00000103187" "COTL1" "B2RDU3; D3DUL9; hsa:23406; Q14019; Q86XM5" "Neutrophil degranulation" "" "1" "0" "0.971" "1.016" "1.011" "0.988" "1.011" "0.956" "0.883" "0.939" "0.916" "4108.1" "3988.7" "4172.1" "4153.0" "4060.8" "4152.3" "3929.0" "3627.6" "3857.3" "3762.7" "" "" "" "" "" "" "" "" "" "" "3299.6" "2878.2" "3314.1" "2782.5" "2808.5" "3115.4" "2750.9" "2649.2" "3857.3" "3059.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626058579617190840" "False" "High" "IsMasterProtein" "Q5VYS8" "Terminal uridylyltransferase 7 OS=Homo sapiens OX=9606 GN=TUT7 PE=1 SV=1" "0.000" "False" "56.157" "9" "12" "14" "12" "1495" "171.1" "6.83" "44.53" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf03828, Pf16631, Pf19088" "79670" "ENSG00000083223" "TUT7" "hsa:79670; Q5H9T0; Q5VYS5; Q5VYS7; Q5VYS8; Q658Z9; Q659A2; Q6MZJ3; Q8N5F0; Q96N57; Q96NE8; Q9C0F2; Q9H8M6" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "" "3" "0" "1.034" "1.019" "1.018" "1.045" "1.021" "1.035" "1.030" "1.078" "1.068" "823.1" "851.1" "838.5" "837.8" "860.3" "840.7" "851.9" "847.4" "887.2" "879.4" "" "" "" "" "" "" "" "" "" "" "661.1" "614.1" "666.1" "561.3" "595.0" "630.8" "596.4" "618.9" "887.2" "715.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8311044657227682609" "False" "High" "IsMasterProtein" "Q9BZE9" "Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1" "0.000" "False" "56.156" "19" "8" "10" "8" "553" "60.1" "6.64" "43.23" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf00789, Pf11470" "79058" "ENSG00000169696" "ASPSCR1" "A8K3K9; hsa:79058; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; Q9BZE9" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "0.994" "0.936" "0.986" "1.003" "0.993" "0.960" "0.977" "0.982" "1.023" "1085.2" "1078.7" "1015.7" "1069.9" "1088.7" "1078.0" "1041.3" "1060.3" "1066.0" "1110.5" "" "" "" "" "" "" "" "" "" "" "871.6" "778.4" "806.8" "716.8" "752.9" "808.8" "729.1" "774.3" "1066.0" "903.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8333902830713908614" "False" "High" "IsMasterProtein" "P05388" "Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "0.000" "False" "56.155" "25" "7" "13" "7" "317" "34.3" "5.97" "44.60" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "0.884" "1.039" "0.912" "0.974" "1.016" "0.983" "1.007" "0.949" "0.976" "1097.2" "970.3" "1139.5" "1000.8" "1068.9" "1114.6" "1078.5" "1105.1" "1041.6" "1071.0" "" "" "" "" "" "" "" "" "" "" "881.2" "700.1" "905.1" "670.5" "739.3" "836.3" "755.1" "807.1" "1041.6" "871.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8818107332528144144" "False" "High" "IsMasterProtein" "Q9H4E7" "Differentially expressed in FDCP 6 homolog OS=Homo sapiens OX=9606 GN=DEF6 PE=1 SV=1" "0.000" "False" "56.144" "14" "9" "17" "8" "631" "73.9" "6.05" "47.92" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00169" "50619" "ENSG00000023892" "DEF6" "hsa:50619; Q86VF4; Q9H4E7" "CDC42 GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle" "" "4" "0" "1.013" "1.034" "1.111" "1.080" "1.074" "1.047" "1.021" "1.115" "1.061" "915.4" "927.5" "946.4" "1016.8" "988.5" "983.4" "958.1" "934.8" "1020.9" "971.4" "" "" "" "" "" "" "" "" "" "" "735.2" "669.2" "751.7" "681.3" "683.7" "737.8" "670.8" "682.7" "1020.9" "789.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831318780158998432" "False" "High" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "0.000" "False" "56.139" "38" "14" "25" "14" "392" "42.9" "7.09" "75.10" "14" "" "other cell component" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "" "2q37 copy number variation syndrome" "1" "0" "0.969" "0.916" "0.939" "0.988" "0.975" "0.933" "0.933" "0.942" "0.955" "2356.5" "2284.1" "2158.9" "2212.2" "2327.2" "2298.1" "2198.1" "2199.2" "2218.7" "2250.4" "" "" "" "" "" "" "" "" "" "" "1892.7" "1648.1" "1714.9" "1482.2" "1609.5" "1724.2" "1539.0" "1606.1" "2218.7" "1830.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-411341991637906360" "False" "High" "IsMasterProtein" "P27448" "MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5" "0.000" "False" "56.139" "18" "12" "22" "10" "753" "84.4" "9.57" "57.33" "12" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "4140" "ENSG00000075413" "MARK3" "A0A0A0MQR8; A0A0A0MST9; A0A0A0MT23; hsa:4140; O60219; P27448; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34" "Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Complement system in neuronal development and plasticity" "10" "0" "0.938" "0.971" "1.000" "0.946" "0.973" "0.998" "1.004" "1.049" "0.996" "1462.5" "1372.3" "1420.0" "1461.8" "1384.1" "1422.9" "1458.8" "1468.3" "1534.4" "1456.7" "" "" "" "" "" "" "" "" "" "" "1174.6" "990.2" "1127.9" "979.4" "957.2" "1067.6" "1021.4" "1072.3" "1534.4" "1184.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7058356130293402746" "False" "High" "IsMasterProtein" "Q6ZRS2" "Helicase SRCAP OS=Homo sapiens OX=9606 GN=SRCAP PE=1 SV=3" "0.000" "False" "56.113" "4" "11" "14" "11" "3230" "343.3" "5.96" "47.10" "11" "cell organization and biogenesis;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529" "10847" "ENSG00000080603" "SRCAP" "B0JZA6; hsa:10847; O15026; Q6ZRS2; Q7Z744; Q9Y5L9" "" "Pathways affected in adenoid cystic carcinoma" "1" "0" "1.012" "0.934" "1.030" "0.976" "0.967" "1.002" "1.032" "0.963" "1.011" "601.8" "609.0" "561.9" "620.0" "587.3" "581.9" "603.2" "620.8" "579.7" "608.7" "" "" "" "" "" "" "" "" "" "" "483.4" "439.5" "446.3" "415.4" "406.2" "436.6" "422.3" "453.4" "579.7" "495.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3948795116760064813" "False" "High" "IsMasterProtein" "Q7Z2Z2" "Elongation factor-like GTPase 1 OS=Homo sapiens OX=9606 GN=EFL1 PE=1 SV=2" "0.000" "False" "56.063" "11" "10" "13" "10" "1120" "125.4" "5.91" "48.71" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf14492" "79631" "ENSG00000140598" "EFL1" "A6NKY5; B7Z6I0; hsa:79631; Q7Z2Z2; Q9H8Z6" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "0.981" "0.954" "1.036" "0.956" "0.951" "1.043" "0.968" "0.965" "0.994" "885.3" "868.4" "844.4" "917.5" "846.5" "841.7" "923.2" "857.4" "854.6" "879.8" "" "" "" "" "" "" "" "" "" "" "711.1" "626.6" "670.7" "614.8" "585.5" "631.5" "646.4" "626.1" "854.6" "715.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3968134916858178565" "False" "High" "IsMasterProtein" "P61247" "Small ribosomal subunit protein eS1 OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "0.000" "False" "56.043" "44" "12" "17" "12" "264" "29.9" "9.73" "52.92" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425; ENSG00000292158" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.952" "1.130" "1.088" "1.051" "1.009" "1.099" "0.943" "1.017" "0.979" "1403.3" "1335.6" "1586.1" "1526.7" "1474.2" "1415.8" "1542.9" "1323.8" "1426.8" "1374.1" "" "" "" "" "" "" "" "" "" "" "1127.1" "963.7" "1259.9" "1022.9" "1019.6" "1062.3" "1080.2" "966.8" "1426.8" "1117.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529586358305545684" "False" "High" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "0.000" "False" "56.012" "20" "7" "15" "7" "439" "48.5" "7.03" "55.59" "7" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Glutamate and glutamine metabolism" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "4" "0" "0.969" "0.962" "0.998" "1.000" "0.983" "0.985" "0.975" "0.975" "0.962" "1059.4" "1026.5" "1018.7" "1057.2" "1059.2" "1041.7" "1043.2" "1033.0" "1032.7" "1019.1" "" "" "" "" "" "" "" "" "" "" "850.9" "740.7" "809.2" "708.4" "732.6" "781.5" "730.4" "754.4" "1032.7" "828.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7983353042055504763" "False" "High" "IsMasterProtein" "Q6SZW1" "NAD(+) hydrolase SARM1 OS=Homo sapiens OX=9606 GN=SARM1 PE=1 SV=1" "0.000" "False" "55.894" "16" "10" "11" "10" "724" "79.3" "6.55" "35.40" "10" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf07647, Pf13676" "23098" "ENSG00000004139" "SARM1" "hsa:23098; O60277; Q6SZW1; Q7LGG3; Q9NXY5" "" "" "0" "0" "1.001" "1.019" "1.061" "1.059" "1.074" "1.061" "1.051" "1.035" "1.086" "664.2" "664.5" "676.7" "704.5" "703.7" "713.3" "704.7" "698.0" "687.6" "721.2" "" "" "" "" "" "" "" "" "" "" "533.5" "479.5" "537.6" "472.0" "486.7" "535.2" "493.4" "509.8" "687.6" "586.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106966376198238351" "False" "High" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "0.000" "False" "55.888" "15" "8" "17" "8" "656" "68.4" "9.33" "63.25" "8" "" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.031" "1.026" "0.979" "0.970" "1.027" "0.976" "1.014" "1.002" "1.006" "2001.1" "2063.3" "2052.9" "1959.0" "1941.4" "2055.2" "1952.2" "2029.2" "2004.9" "2013.0" "" "" "" "" "" "" "" "" "" "" "1607.3" "1488.8" "1630.7" "1312.5" "1342.7" "1542.0" "1366.9" "1481.9" "2004.9" "1637.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5557556089384344895" "False" "High" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "0.000" "False" "55.848" "25" "10" "19" "10" "482" "54.1" "5.55" "54.50" "10" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "0" "0.972" "0.969" "0.978" "0.995" "0.989" "1.056" "1.055" "1.004" "0.981" "1591.5" "1547.1" "1541.9" "1556.1" "1583.0" "1574.2" "1680.5" "1679.7" "1598.2" "1560.9" "" "" "" "" "" "" "" "" "" "" "1278.3" "1116.3" "1224.7" "1042.6" "1094.8" "1181.1" "1176.6" "1226.7" "1598.2" "1269.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8005883181375695291" "False" "High" "IsMasterProtein" "Q9P260" "RAB11-binding protein RELCH OS=Homo sapiens OX=9606 GN=RELCH PE=1 SV=2" "0.000" "False" "55.825" "12" "11" "11" "11" "1216" "134.5" "5.45" "37.37" "11" "transport" "ER/Golgi;other cytoplasmic organelle" "" "" "57614" "ENSG00000134444" "RELCH" "hsa:57614; Q9P260" "" "" "0" "0" "0.985" "1.013" "0.988" "1.020" "0.967" "0.933" "1.060" "1.015" "1.005" "1044.5" "1028.5" "1058.1" "1032.1" "1065.5" "1010.4" "974.8" "1107.1" "1060.5" "1049.9" "" "" "" "" "" "" "" "" "" "" "838.9" "742.1" "840.5" "691.5" "736.9" "758.1" "682.5" "808.5" "1060.5" "853.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595092831186639682" "False" "High" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "0.000" "False" "55.804" "27" "9" "21" "9" "368" "41.5" "5.43" "71.95" "9" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "Fragile X syndrome" "6" "0" "0.978" "0.970" "0.965" "0.920" "0.947" "0.939" "0.941" "0.981" "0.936" "2116.2" "2070.4" "2052.5" "2042.0" "1947.0" "2003.9" "1986.3" "1991.7" "2076.4" "1980.0" "" "" "" "" "" "" "" "" "" "" "1699.7" "1494.0" "1630.4" "1368.1" "1346.6" "1503.5" "1390.7" "1454.6" "2076.4" "1610.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4190434278171363026" "False" "High" "IsMasterProtein" "Q92547" "DNA topoisomerase 2-binding protein 1 OS=Homo sapiens OX=9606 GN=TOPBP1 PE=1 SV=3" "0.000" "False" "55.781" "11" "14" "16" "14" "1522" "170.6" "6.96" "50.57" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00533" "11073" "ENSG00000163781" "TOPBP1" "B7Z7W8; hsa:11073; Q7LGC1; Q92547; Q9UEB9" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "ATR signaling" "7" "0" "1.004" "1.003" "1.002" "1.010" "1.023" "1.062" "1.061" "1.080" "1.084" "1518.9" "1525.1" "1523.1" "1521.6" "1533.8" "1554.4" "1612.8" "1611.9" "1641.1" "1646.8" "" "" "" "" "" "" "" "" "" "" "1219.9" "1100.5" "1209.8" "1019.5" "1060.8" "1166.2" "1129.2" "1177.2" "1641.1" "1339.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7644336301377244123" "False" "High" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "0.000" "False" "55.716" "15" "9" "10" "9" "802" "85.1" "6.79" "42.01" "9" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "0.994" "1.002" "1.036" "1.013" "1.056" "0.940" "0.986" "0.962" "0.990" "727.5" "723.2" "728.7" "753.8" "736.8" "768.3" "684.0" "717.0" "699.7" "720.4" "" "" "" "" "" "" "" "" "" "" "584.3" "521.8" "578.8" "505.0" "509.6" "576.4" "478.9" "523.6" "699.7" "585.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144550306187805462" "False" "High" "IsMasterProtein" "Q68E01" "Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1" "0.000" "False" "55.640" "15" "12" "16" "12" "1043" "118.0" "5.80" "54.13" "12" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf10189" "65123" "ENSG00000143624; ENSG00000262826" "INTS3" "A8K1W0; B4DQC8; B4E3U9; D3DV57; hsa:65123; Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q68E01; Q69YR5; Q6AI57; Q6DKG7; Q6MZQ4; Q6MZZ9; Q8NC46; Q8TB23; Q9H6S9" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.973" "1.009" "1.048" "0.984" "0.996" "0.998" "0.973" "1.014" "1.011" "1380.3" "1343.0" "1392.5" "1446.2" "1358.9" "1374.3" "1378.0" "1342.8" "1399.4" "1396.0" "" "" "" "" "" "" "" "" "" "" "1108.7" "969.1" "1106.1" "968.9" "939.8" "1031.1" "964.8" "980.7" "1399.4" "1135.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5647730209445312513" "False" "High" "IsMasterProtein" "Q9BWT3" "Poly(A) polymerase gamma OS=Homo sapiens OX=9606 GN=PAPOLG PE=1 SV=2" "0.000" "False" "55.615" "19" "13" "17" "9" "736" "82.8" "9.14" "47.61" "13" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "64895" "ENSG00000115421" "PAPOLG" "B2RBH4; hsa:64895; Q59G05; Q969N1; Q9BWT3; Q9H8L2; Q9HAD0" "" "" "0" "0" "1.004" "0.989" "1.146" "1.059" "0.975" "1.102" "1.076" "1.154" "1.079" "437.3" "439.1" "432.6" "501.3" "463.2" "426.5" "482.0" "470.5" "504.7" "471.8" "" "" "" "" "" "" "" "" "" "" "351.2" "316.9" "343.7" "335.9" "320.3" "320.0" "337.5" "343.6" "504.7" "383.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991678768207076864" "False" "High" "IsMasterProtein" "Q9UNF1" "Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2" "0.000" "False" "55.587" "23" "12" "17" "12" "606" "64.9" "9.32" "53.23" "12" "transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01454" "10916" "ENSG00000102316" "MAGED2" "A6NMX0; hsa:10916; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; Q9UNF1" "Platelet degranulation" "" "1" "0" "1.021" "0.972" "0.982" "0.954" "0.968" "0.933" "1.037" "1.030" "1.010" "1737.8" "1773.9" "1689.2" "1707.2" "1657.9" "1681.9" "1622.1" "1801.5" "1789.6" "1755.4" "" "" "" "" "" "" "" "" "" "" "1395.8" "1280.0" "1341.8" "1143.8" "1146.7" "1261.9" "1135.7" "1315.6" "1789.6" "1427.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446725702153589765" "False" "High" "IsMasterProtein" "Q9Y2T2" "AP-3 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP3M1 PE=1 SV=1" "0.000" "False" "55.528" "30" "10" "15" "8" "418" "46.9" "6.93" "49.85" "10" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "26985" "ENSG00000185009" "AP3M1" "hsa:26985; Q5JQ12; Q9H5L2; Q9Y2T2" "Association of TriC/CCT with target proteins during biosynthesis" "" "1" "1" "0.986" "0.962" "0.969" "0.986" "0.941" "0.919" "0.994" "0.922" "0.987" "1440.2" "1419.9" "1385.8" "1396.3" "1419.7" "1355.9" "1323.1" "1431.8" "1327.4" "1421.8" "" "" "" "" "" "" "" "" "" "" "1156.8" "1024.6" "1100.8" "935.5" "981.9" "1017.3" "926.4" "1045.7" "1327.4" "1156.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177067630619702561" "False" "High" "IsMasterProtein" "Q969S9" "Ribosome-releasing factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=GFM2 PE=1 SV=1" "0.000" "False" "55.480" "13" "9" "13" "9" "779" "86.5" "6.51" "44.72" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "84340" "ENSG00000164347" "GFM2" "A0AR28; hsa:84340; Q8N6D8; Q8WYI0; Q969S9; Q9H6Z1" "Mitochondrial translation termination" "" "1" "0" "1.057" "1.006" "1.047" "1.095" "1.012" "1.032" "1.004" "1.047" "1.073" "1105.1" "1168.2" "1111.8" "1156.8" "1209.9" "1118.4" "1140.7" "1109.1" "1157.4" "1186.3" "" "" "" "" "" "" "" "" "" "" "887.6" "842.9" "883.2" "775.0" "836.8" "839.1" "798.7" "810.0" "1157.4" "964.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65550439794871329" "False" "High" "IsMasterProtein" "Q9BXS5" "AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3" "0.000" "False" "55.467" "33" "12" "25" "12" "423" "48.6" "7.30" "87.59" "12" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "8907" "ENSG00000072958" "AP1M1" "hsa:8907; Q4TTY5; Q9BXS5" "Neutrophil degranulation; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "5" "0" "0.987" "0.968" "1.020" "1.053" "1.075" "0.966" "0.999" "1.028" "1.061" "1449.7" "1430.4" "1404.0" "1479.3" "1526.1" "1558.9" "1400.1" "1448.1" "1490.8" "1537.6" "" "" "" "" "" "" "" "" "" "" "1164.4" "1032.2" "1115.2" "991.2" "1055.4" "1169.6" "980.3" "1057.5" "1490.8" "1250.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3933333122988886366" "False" "High" "IsMasterProtein" "Q6ZNJ1" "Neurobeachin-like protein 2 OS=Homo sapiens OX=9606 GN=NBEAL2 PE=1 SV=2" "0.000" "False" "55.466" "5" "11" "12" "11" "2754" "302.3" "6.38" "40.24" "11" "other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf02138, Pf14844, Pf15787, Pf16057, Pf20425, Pf20426" "23218" "ENSG00000160796" "NBEAL2" "hsa:23218; O60288; Q6P994; Q6UX91; Q6ZNJ1; Q8NAC9" "Neutrophil degranulation" "" "1" "0" "1.005" "1.057" "1.058" "1.081" "1.015" "0.979" "1.001" "1.031" "1.039" "533.9" "536.7" "564.6" "565.1" "577.2" "542.1" "522.6" "534.6" "550.6" "554.9" "" "" "" "" "" "" "" "" "" "" "428.9" "387.3" "448.5" "378.6" "399.2" "406.8" "365.9" "390.5" "550.6" "451.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4682343242687865588" "False" "High" "IsMasterProtein" "O43818" "U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1" "0.000" "False" "55.465" "22" "11" "17" "11" "475" "51.8" "7.85" "60.49" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400" "9136" "ENSG00000114767" "RRP9" "B2R996; hsa:9136; O43818; Q8IZ30" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.032" "1.048" "1.006" "1.020" "1.009" "1.008" "1.049" "1.045" "1.044" "1754.4" "1809.8" "1838.6" "1765.3" "1789.0" "1770.4" "1769.0" "1839.6" "1832.8" "1831.8" "" "" "" "" "" "" "" "" "" "" "1409.1" "1305.9" "1460.4" "1182.8" "1237.3" "1328.3" "1238.6" "1343.5" "1832.8" "1489.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5615919369887998349" "False" "High" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "0.000" "False" "55.460" "31" "7" "16" "6" "392" "42.9" "5.97" "53.30" "7" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "1" "1.030" "1.069" "1.186" "1.091" "1.067" "1.042" "1.143" "1.055" "1.063" "1036.1" "1067.1" "1107.1" "1228.4" "1130.4" "1105.2" "1079.2" "1184.1" "1092.6" "1101.1" "" "" "" "" "" "" "" "" "" "" "832.2" "770.0" "879.4" "823.0" "781.8" "829.2" "755.6" "864.8" "1092.6" "895.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2851468461982241185" "False" "High" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "0.000" "False" "55.427" "32" "6" "20" "6" "198" "21.7" "5.59" "62.90" "6" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13499, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "" "5" "0" "1.035" "1.001" "1.001" "1.014" "1.023" "1.057" "1.046" "1.057" "1.006" "1782.8" "1844.5" "1784.7" "1784.3" "1807.7" "1824.1" "1883.6" "1864.4" "1885.2" "1794.0" "" "" "" "" "" "" "" "" "" "" "1431.9" "1330.9" "1417.7" "1195.5" "1250.2" "1368.6" "1318.8" "1361.6" "1885.2" "1458.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4890762250346228692" "False" "High" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "0.000" "False" "55.423" "37" "11" "22" "11" "354" "39.1" "6.44" "61.46" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "27" "0" "1.028" "1.083" "1.004" "0.997" "0.972" "0.952" "1.089" "1.131" "1.028" "852.1" "876.1" "922.9" "855.6" "849.6" "827.9" "811.2" "928.1" "963.9" "875.6" "" "" "" "" "" "" "" "" "" "" "684.4" "632.1" "733.1" "573.2" "587.6" "621.1" "568.0" "677.8" "963.9" "712.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1728322554936911435" "False" "High" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "0.000" "False" "55.412" "14" "11" "25" "11" "699" "73.6" "9.47" "70.50" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "0.888" "1.018" "0.999" "0.927" "1.002" "1.190" "1.133" "1.102" "1.010" "1684.5" "1495.1" "1714.7" "1682.0" "1561.0" "1687.3" "2005.2" "1908.5" "1856.0" "1701.2" "" "" "" "" "" "" "" "" "" "" "1352.9" "1078.8" "1362.0" "1126.9" "1079.6" "1266.0" "1404.0" "1393.8" "1856.0" "1383.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3318503761924520630" "False" "High" "IsMasterProtein" "Q96R06" "Sperm-associated antigen 5 OS=Homo sapiens OX=9606 GN=SPAG5 PE=1 SV=2" "0.000" "False" "55.349" "11" "13" "16" "13" "1193" "134.3" "5.00" "41.88" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "10615" "ENSG00000076382" "SPAG5" "hsa:10615; O95213; Q96R06; Q9BWE8; Q9NT17; Q9UFE6" "" "" "0" "0" "0.980" "0.972" "1.004" "0.970" "0.904" "0.912" "0.972" "0.941" "1.033" "934.8" "916.0" "909.1" "939.0" "907.1" "844.9" "852.7" "908.4" "879.7" "965.7" "" "" "" "" "" "" "" "" "" "" "750.9" "661.0" "722.1" "629.1" "627.4" "633.9" "597.0" "663.4" "879.7" "785.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515792609303095651" "False" "High" "IsMasterProtein" "P61204" "ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2" "0.000" "False" "55.274" "55" "8" "22" "3" "181" "20.6" "7.43" "67.23" "8" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "377" "ENSG00000134287" "ARF3" "A8K6G8; B7ZB63; hsa:377; P16587; P61204" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane" "" "3" "0" "0.962" "0.877" "0.919" "1.027" "1.011" "0.960" "0.971" "0.888" "0.924" "480.3" "462.2" "421.3" "441.4" "493.5" "485.4" "461.1" "466.1" "426.7" "443.7" "" "" "" "" "" "" "" "" "" "" "385.8" "333.5" "334.6" "295.7" "341.3" "364.2" "322.8" "340.4" "426.7" "360.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1199984255511246690" "False" "High" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "0.000" "False" "55.190" "19" "12" "14" "12" "733" "75.4" "9.32" "46.41" "12" "other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "UCH proteinases" "" "1" "0" "1.051" "1.026" "0.982" "1.046" "1.019" "1.062" "1.059" "1.055" "1.082" "570.7" "599.6" "585.2" "560.2" "596.8" "581.8" "605.9" "604.2" "602.1" "617.3" "" "" "" "" "" "" "" "" "" "" "458.4" "432.6" "464.9" "375.4" "412.8" "436.5" "424.2" "441.2" "602.1" "502.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7347727386660618652" "False" "High" "IsMasterProtein" "Q8IUI8" "Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2" "0.000" "False" "55.185" "23" "9" "15" "9" "442" "49.7" "5.14" "53.51" "9" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "51379" "ENSG00000176390" "CRLF3" "A6NJF3; B2R8C3; hsa:51379; Q2MLY7; Q8IUI8; Q9UNI3; Q9Y6M8" "" "NF1 copy number variation syndrome" "1" "0" "1.066" "1.080" "1.125" "1.132" "1.072" "1.002" "1.078" "1.018" "1.105" "858.7" "915.5" "927.4" "965.9" "971.8" "920.2" "860.7" "925.6" "874.0" "948.7" "" "" "" "" "" "" "" "" "" "" "689.7" "660.6" "736.7" "647.1" "672.1" "690.4" "602.6" "676.0" "874.0" "771.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2840679928359396214" "False" "High" "IsMasterProtein" "Q6P1N0" "Coiled-coil and C2 domain-containing protein 1A OS=Homo sapiens OX=9606 GN=CC2D1A PE=1 SV=1" "0.000" "False" "55.128" "13" "13" "15" "12" "951" "104.0" "8.09" "50.38" "13" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "54862" "ENSG00000132024; ENSG00000288293" "CC2D1A" "hsa:54862; Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1" "" "Sudden infant death syndrome (SIDS) susceptibility pathways" "1" "1" "1.087" "1.008" "1.030" "1.036" "0.955" "1.123" "1.095" "1.033" "1.045" "1697.3" "1845.4" "1710.4" "1748.8" "1759.1" "1620.1" "1905.4" "1858.4" "1753.9" "1773.8" "" "" "" "" "" "" "" "" "" "" "1363.2" "1331.6" "1358.7" "1171.7" "1216.6" "1215.6" "1334.1" "1357.2" "1753.9" "1442.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7053379414769105992" "False" "High" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "0.000" "False" "55.086" "37" "10" "15" "10" "334" "37.6" "6.54" "56.26" "10" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; Neddylation; DNA Damage Recognition in GG-NER" "TGF-beta signaling pathway" "5" "0" "0.961" "0.982" "1.001" "0.994" "0.971" "0.928" "0.963" "0.901" "0.991" "1244.1" "1195.2" "1221.6" "1245.6" "1236.0" "1208.3" "1154.3" "1197.4" "1120.9" "1232.7" "" "" "" "" "" "" "" "" "" "" "999.2" "862.4" "970.3" "834.6" "854.9" "906.6" "808.2" "874.5" "1120.9" "1002.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4125655909395712746" "False" "High" "IsMasterProtein" "Q8IUR7" "Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2" "0.000" "False" "55.067" "18" "11" "14" "11" "673" "75.5" "6.73" "38.95" "11" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00514" "25852" "ENSG00000114098" "ARMC8" "A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; hsa:25852; Q6PIL2; Q8IUR7; Q96D19; Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9" "Neutrophil degranulation" "Ciliary landscape" "2" "0" "0.960" "0.962" "0.953" "0.995" "0.992" "0.963" "0.966" "0.908" "0.967" "1307.8" "1255.4" "1257.7" "1245.8" "1300.7" "1297.8" "1259.0" "1263.2" "1186.9" "1264.3" "" "" "" "" "" "" "" "" "" "" "1050.4" "905.8" "999.0" "834.7" "899.6" "973.7" "881.5" "922.5" "1186.9" "1028.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6425786624467733847" "False" "High" "IsMasterProtein" "O95758" "Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2" "0.000" "False" "54.974" "21" "10" "17" "7" "552" "59.7" "9.04" "56.81" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11835, Pf13893" "9991" "ENSG00000119314" "PTBP3" "B1ALY2; B1ALY3; B1ALY5; B1ALY6; B3KME7; hsa:9991; O95758; Q68DB9; Q86YB3; Q86YH9" "" "" "0" "0" "1.008" "1.104" "1.003" "1.092" "1.015" "0.993" "1.046" "1.016" "1.025" "809.3" "815.5" "893.4" "812.0" "883.4" "821.2" "803.6" "846.2" "822.0" "829.9" "" "" "" "" "" "" "" "" "" "" "650.0" "588.4" "709.7" "544.0" "611.0" "616.1" "562.6" "618.0" "822.0" "674.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015398897820644174" "False" "High" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "0.000" "False" "54.962" "22" "10" "14" "10" "476" "54.4" "8.25" "45.60" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "18" "0" "1.015" "1.003" "0.988" "0.999" "0.950" "0.848" "0.891" "0.882" "0.948" "1302.1" "1321.8" "1306.5" "1286.5" "1300.2" "1237.6" "1103.9" "1160.7" "1148.2" "1234.2" "" "" "" "" "" "" "" "" "" "" "1045.8" "953.8" "1037.8" "861.9" "899.2" "928.5" "772.9" "847.7" "1148.2" "1003.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762449723745155897" "False" "High" "IsMasterProtein" "Q9H5V9" "STING ER exit protein OS=Homo sapiens OX=9606 GN=STEEP1 PE=1 SV=1" "0.000" "False" "54.953" "38" "7" "12" "7" "222" "25.6" "8.73" "49.95" "7" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "mRNA Splicing - Major Pathway" "" "1" "0" "1.031" "0.997" "1.042" "1.024" "1.022" "1.025" "0.990" "1.074" "1.096" "724.8" "747.5" "722.5" "755.3" "742.0" "741.1" "742.9" "717.7" "778.6" "794.2" "" "" "" "" "" "" "" "" "" "" "582.2" "539.4" "573.9" "506.0" "513.2" "556.0" "520.1" "524.1" "778.6" "645.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465801585106187641" "False" "High" "IsMasterProtein" "P52735" "Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9606 GN=VAV2 PE=1 SV=2" "0.000" "False" "54.947" "13" "10" "13" "10" "878" "101.2" "7.08" "50.01" "10" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00130, Pf00169, Pf00307, Pf00621, Pf07653" "7410" "ENSG00000160293" "VAV2" "A2RUM4; A8MQ12; B6ZDF5; hsa:7410; P52735; Q5SYV3; Q5SYV4; Q5SYV5; Q6N012; Q6PIJ9; Q6Q317" "EPH-ephrin mediated repulsion of cells; VEGFR2 mediated vascular permeability; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; GPVI-mediated activation cascade; DAP12 signaling; Signal transduction by L1; Azathioprine ADME" "Integrin-mediated cell adhesion; Prolactin signaling pathway; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Focal adhesion; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Ebola virus infection in host; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; GDNF signaling" "34" "0" "0.950" "0.879" "0.960" "0.942" "0.918" "0.886" "0.900" "0.912" "0.940" "663.0" "630.1" "582.5" "636.5" "624.5" "608.5" "587.6" "596.6" "604.7" "623.3" "" "" "" "" "" "" "" "" "" "" "532.5" "454.7" "462.7" "426.5" "431.9" "456.5" "411.4" "435.7" "604.7" "506.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1664770674535561933" "False" "High" "IsMasterProtein" "Q96T37" "RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2" "0.000" "False" "54.929" "11" "8" "11" "8" "977" "107.1" "10.08" "42.64" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf07744" "64783" "ENSG00000162775" "RBM15" "A1A693; hsa:64783; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; Q96T37; Q96T38; Q9BRA5; Q9H6R8; Q9H9Y0" "" "" "0" "0" "1.009" "0.997" "1.107" "1.125" "1.129" "1.143" "1.017" "1.105" "1.105" "693.8" "700.0" "691.6" "768.2" "780.4" "783.4" "792.9" "705.6" "766.7" "766.3" "" "" "" "" "" "" "" "" "" "" "557.3" "505.1" "549.4" "514.7" "539.7" "587.8" "555.2" "515.3" "766.7" "623.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9128345059399950903" "False" "High" "IsMasterProtein" "P83436" "Conserved oligomeric Golgi complex subunit 7 OS=Homo sapiens OX=9606 GN=COG7 PE=1 SV=1" "0.000" "False" "54.803" "13" "10" "11" "10" "770" "86.3" "5.47" "40.58" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "" "Pf10191" "91949" "ENSG00000168434" "COG7" "hsa:91949; P83436; Q6UWU7" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "1.041" "0.982" "1.049" "1.006" "1.015" "1.028" "1.048" "1.061" "1.039" "1190.5" "1238.9" "1169.2" "1249.0" "1198.1" "1207.8" "1223.5" "1247.2" "1262.6" "1237.1" "" "" "" "" "" "" "" "" "" "" "956.2" "893.9" "928.7" "836.8" "828.6" "906.2" "856.6" "910.8" "1262.6" "1006.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3913128170310311305" "False" "High" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "0.000" "False" "54.802" "38" "10" "26" "10" "310" "34.6" "6.52" "79.36" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "0.973" "0.964" "0.988" "0.866" "0.950" "0.902" "0.869" "0.858" "0.915" "2776.3" "2700.6" "2675.4" "2743.3" "2404.8" "2637.3" "2503.5" "2412.5" "2381.9" "2540.4" "" "" "" "" "" "" "" "" "" "" "2229.9" "1948.6" "2125.1" "1838.0" "1663.2" "1978.7" "1752.8" "1761.9" "2381.9" "2066.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3384207672428186398" "False" "High" "IsMasterProtein" "Q8N335" "Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1" "0.000" "False" "54.767" "45" "13" "17" "13" "351" "38.4" "7.02" "50.03" "13" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "23171" "ENSG00000152642" "GPD1L" "A8K9U3; hsa:23171; Q14702; Q8N335; Q9BRM5" "Synthesis of PA" "Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "0" "1.071" "0.971" "0.971" "1.019" "0.934" "0.943" "0.978" "0.960" "0.947" "961.6" "1030.3" "933.9" "934.0" "979.5" "898.5" "907.1" "940.3" "923.0" "911.0" "" "" "" "" "" "" "" "" "" "" "772.3" "743.4" "741.8" "625.8" "677.4" "674.1" "635.1" "686.7" "923.0" "740.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670005547915153643" "False" "High" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "0.000" "False" "54.734" "38" "7" "10" "7" "261" "29.8" "5.55" "40.71" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "0.976" "0.984" "1.010" "1.036" "1.003" "1.055" "1.100" "1.050" "0.982" "714.8" "697.4" "703.3" "722.2" "740.8" "716.8" "754.1" "786.6" "750.8" "702.2" "" "" "" "" "" "" "" "" "" "" "574.1" "503.2" "558.6" "483.9" "512.4" "537.8" "528.0" "574.5" "750.8" "571.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659608677254824690" "False" "High" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "0.000" "False" "54.655" "26" "8" "15" "8" "386" "43.2" "7.17" "46.56" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "Inactivation, recovery and regulation of the phototransduction cascade" "" "1" "0" "0.958" "0.947" "1.017" "1.033" "1.014" "1.014" "0.934" "1.025" "1.036" "787.7" "754.8" "745.9" "801.4" "813.3" "798.8" "799.1" "735.4" "807.4" "815.9" "" "" "" "" "" "" "" "" "" "" "632.6" "544.6" "592.5" "537.0" "562.5" "599.3" "559.5" "537.0" "807.4" "663.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5527327330749920032" "False" "High" "IsMasterProtein" "P61019" "Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1" "0.000" "False" "54.645" "51" "8" "13" "4" "212" "23.5" "6.54" "49.56" "8" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "5862" "ENSG00000104388" "RAB2A" "B2R5W8; B4DMQ5; hsa:5862; P08886; P61019" "RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "4" "3" "0.976" "1.082" "0.980" "1.025" "1.076" "0.955" "0.967" "0.979" "1.008" "1569.1" "1530.8" "1697.3" "1537.1" "1608.7" "1688.2" "1498.0" "1517.0" "1536.1" "1581.9" "" "" "" "" "" "" "" "" "" "" "1260.2" "1104.6" "1348.2" "1029.9" "1112.6" "1266.6" "1048.8" "1107.9" "1536.1" "1286.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1560013588739463450" "False" "High" "IsMasterProtein" "Q9H7D7" "WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3" "0.000" "False" "54.596" "20" "11" "14" "11" "661" "72.1" "6.16" "42.78" "11" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400, Pf17814" "80232" "ENSG00000162923" "WDR26" "A0MNN3; hsa:80232; Q4G100; Q59EC4; Q5GLZ9; Q86UY4; Q9H3C2; Q9H7D7" "" "Ciliary landscape" "1" "0" "1.009" "0.990" "0.953" "1.036" "0.950" "0.870" "0.925" "0.998" "0.991" "1088.0" "1097.4" "1076.8" "1037.4" "1127.5" "1033.2" "947.0" "1006.7" "1085.9" "1078.0" "" "" "" "" "" "" "" "" "" "" "873.9" "791.9" "855.3" "695.1" "779.8" "775.2" "663.0" "735.2" "1085.9" "876.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8166763961734876416" "False" "High" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "0.000" "False" "54.574" "24" "10" "26" "7" "409" "43.1" "4.84" "71.00" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; HDAC6 interactions in the central nervous system" "8" "2" "1.069" "1.059" "1.032" "0.956" "0.999" "1.014" "0.999" "1.017" "0.961" "2032.0" "2172.6" "2152.2" "2097.5" "1942.3" "2029.0" "2061.0" "2031.0" "2066.4" "1952.1" "" "" "" "" "" "" "" "" "" "" "1632.1" "1567.7" "1709.6" "1405.3" "1343.3" "1522.3" "1443.0" "1483.2" "2066.4" "1587.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6816418598839755867" "False" "High" "IsMasterProtein" "Q9NXC5" "GATOR2 complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "0.000" "False" "54.556" "14" "9" "10" "9" "875" "98.5" "6.73" "33.20" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17034, Pf21719, Pf21720" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "Amino acids regulate mTORC1" "" "1" "0" "1.039" "0.992" "1.139" "1.137" "1.007" "1.135" "1.083" "1.048" "1.101" "660.4" "686.4" "655.2" "752.4" "750.8" "664.8" "749.6" "715.5" "692.2" "726.8" "" "" "" "" "" "" "" "" "" "" "530.4" "495.3" "520.4" "504.1" "519.2" "498.8" "524.9" "522.5" "692.2" "591.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566941551472469516" "False" "High" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "0.000" "False" "54.531" "20" "9" "14" "9" "579" "65.5" "7.06" "46.67" "9" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "5" "0" "1.038" "1.043" "0.987" "1.029" "1.023" "0.978" "0.973" "1.032" "1.031" "871.9" "905.0" "909.4" "860.2" "897.2" "891.6" "853.1" "848.7" "899.8" "899.1" "" "" "" "" "" "" "" "" "" "" "700.3" "653.0" "722.3" "576.4" "620.5" "668.9" "597.3" "619.8" "899.8" "731.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1468233501590493710" "False" "High" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "0.000" "False" "54.457" "18" "9" "15" "9" "514" "57.6" "9.42" "50.41" "9" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "1.023" "1.029" "0.985" "1.101" "1.036" "1.038" "1.044" "1.073" "1.069" "1276.2" "1305.0" "1313.3" "1256.8" "1404.8" "1322.4" "1325.0" "1332.0" "1368.8" "1363.7" "" "" "" "" "" "" "" "" "" "" "1025.0" "941.7" "1043.2" "842.0" "971.5" "992.2" "927.7" "972.7" "1368.8" "1109.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4596787228496680093" "False" "High" "IsMasterProtein" "Q9BV86" "N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3" "0.000" "False" "54.440" "36" "7" "14" "7" "223" "25.4" "5.52" "53.81" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05891" "28989" "ENSG00000148335" "NTMT1" "A8K4J2; A8K8G7; hsa:28989; Q5SZB9; Q9BV86; Q9UI28" "" "" "0" "0" "1.002" "1.043" "1.034" "1.011" "1.027" "0.984" "1.028" "1.004" "1.029" "968.1" "970.5" "1009.9" "1001.3" "978.9" "994.5" "952.4" "995.1" "971.5" "996.4" "" "" "" "" "" "" "" "" "" "" "777.6" "700.3" "802.2" "670.9" "677.0" "746.1" "666.8" "726.7" "971.5" "810.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7795104145569461525" "False" "High" "IsMasterProtein" "Q2M389" "WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2" "0.000" "False" "54.439" "10" "11" "21" "11" "1173" "136.3" "7.44" "54.66" "11" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14744, Pf14745, Pf14746" "23325" "ENSG00000136051" "WASHC4" "hsa:23325; Q2M389; Q2NL83; Q8IW61; Q8N5W7; Q9NVD6; Q9UPW7" "" "" "0" "0" "1.019" "0.985" "1.023" "0.970" "0.980" "0.925" "1.039" "0.941" "0.975" "1437.1" "1463.9" "1415.9" "1469.6" "1394.0" "1408.3" "1330.0" "1493.0" "1351.7" "1401.8" "" "" "" "" "" "" "" "" "" "" "1154.3" "1056.3" "1124.7" "984.6" "964.1" "1056.6" "931.2" "1090.3" "1351.7" "1140.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2449426517635308859" "False" "High" "IsMasterProtein" "Q9H6F5" "Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1" "0.000" "False" "54.402" "33" "10" "14" "10" "360" "40.2" "10.33" "52.13" "10" "" "nucleus;other cell component" "" "Pf03879" "79080" "ENSG00000110104" "CCDC86" "B4DY99; hsa:79080; Q9H6F5" "" "" "0" "0" "1.161" "1.060" "1.143" "1.205" "1.111" "1.273" "1.237" "1.215" "1.095" "584.6" "678.8" "619.5" "668.4" "704.3" "649.2" "744.4" "723.0" "710.0" "640.0" "" "" "" "" "" "" "" "" "" "" "469.5" "489.8" "492.1" "447.8" "487.1" "487.1" "521.2" "528.0" "710.0" "520.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181464862980127615" "False" "High" "IsMasterProtein" "Q13630" "GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=GFUS PE=1 SV=1" "0.000" "False" "54.390" "35" "8" "16" "8" "321" "35.9" "6.60" "53.48" "8" "cell adhesion;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01370" "7264" "ENSG00000104522; ENSG00000278243" "GFUS" "B2R8Y7; D3DWK5; hsa:7264; Q13630; Q567Q9; Q9UDG7" "GDP-fucose biosynthesis" "" "1" "0" "0.919" "0.928" "0.959" "0.940" "0.961" "0.908" "0.924" "0.902" "0.978" "900.0" "827.1" "835.0" "862.8" "845.8" "864.9" "817.6" "831.4" "811.8" "880.5" "" "" "" "" "" "" "" "" "" "" "722.8" "596.8" "663.3" "578.1" "585.0" "648.9" "572.4" "607.1" "811.8" "716.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3232925650926593770" "False" "High" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "0.000" "False" "54.387" "10" "13" "15" "13" "1729" "181.7" "4.86" "46.72" "13" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "Ciliary landscape" "4" "0" "1.081" "1.069" "1.101" "1.126" "1.131" "1.186" "1.102" "1.146" "1.090" "450.9" "487.5" "482.0" "496.6" "507.8" "510.0" "534.9" "496.7" "516.7" "491.5" "" "" "" "" "" "" "" "" "" "" "362.1" "351.7" "382.9" "332.7" "351.2" "382.6" "374.5" "362.8" "516.7" "399.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3589965409300637784" "False" "High" "IsMasterProtein" "Q14691" "DNA replication complex GINS protein PSF1 OS=Homo sapiens OX=9606 GN=GINS1 PE=1 SV=1" "0.000" "False" "54.385" "40" "7" "12" "7" "196" "23.0" "7.39" "41.17" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf05916" "9837" "ENSG00000101003" "GINS1" "hsa:9837; Q14691; Q9NQE2; Q9NQI7" "Unwinding of DNA" "" "1" "0" "0.987" "0.928" "0.983" "1.041" "0.953" "0.995" "0.997" "0.960" "1.017" "751.0" "741.4" "696.8" "738.6" "781.6" "715.4" "747.3" "748.6" "720.6" "763.5" "" "" "" "" "" "" "" "" "" "" "603.2" "535.0" "553.5" "494.8" "540.6" "536.7" "523.2" "546.7" "720.6" "620.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357381019356623363" "False" "High" "IsMasterProtein" "Q15025" "TNFAIP3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TNIP1 PE=1 SV=2" "0.000" "False" "54.369" "16" "9" "11" "9" "636" "71.8" "6.62" "37.47" "9" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "10318" "ENSG00000145901" "TNIP1" "A4F1W8; A4F1W9; A4F1X2; A4F1X4; A4F1X5; A4F1X6; A4F1X7; A4F1X9; B7Z699; E7EPY1; E7ET96; hsa:10318; O76008; Q05KP3; Q05KP4; Q15025; Q6N077; Q96EL9; Q99833; Q9H1J3" "Ovarian tumor domain proteases" "RAC1/PAK1/p38/MMP2 pathway" "2" "0" "1.005" "0.961" "1.034" "1.009" "1.019" "1.023" "0.996" "1.004" "1.029" "870.9" "875.0" "837.0" "900.8" "878.4" "887.1" "890.8" "867.1" "874.8" "896.6" "" "" "" "" "" "" "" "" "" "" "699.5" "631.4" "664.9" "603.5" "607.5" "665.6" "623.7" "633.3" "874.8" "729.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5454865549219062540" "False" "High" "IsMasterProtein" "P14859" "POU domain, class 2, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU2F1 PE=1 SV=2" "0.000" "False" "54.362" "13" "8" "11" "5" "743" "76.4" "6.81" "41.25" "8" "other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157, Pf19536" "5451" "ENSG00000143190" "POU2F1" "B1AL91; B1AL93; B4E029; hsa:5451; J3KP77; P14859; Q5TBT7; Q6PK46; Q8NEU9; Q9BPV1" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling" "Integrated cancer pathway" "6" "3" "1.075" "1.012" "1.043" "1.068" "1.019" "0.939" "1.032" "0.943" "1.026" "874.7" "939.9" "885.0" "912.1" "933.9" "891.6" "821.4" "902.5" "824.6" "897.4" "" "" "" "" "" "" "" "" "" "" "702.5" "678.2" "703.0" "611.1" "645.9" "668.9" "575.1" "659.1" "824.6" "729.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2601253202356678168" "False" "High" "IsMasterProtein" "P31937" "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2" "0.000" "False" "54.347" "24" "5" "11" "5" "336" "35.3" "8.13" "42.67" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf03446, Pf14833" "11112" "ENSG00000106049" "HIBADH" "hsa:11112; P31937; Q546Z2; Q9UDN3" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "1.000" "1.025" "1.098" "0.998" "0.962" "0.971" "0.975" "0.992" "0.995" "804.1" "804.2" "824.5" "882.5" "802.2" "773.5" "780.4" "783.6" "797.8" "799.8" "" "" "" "" "" "" "" "" "" "" "645.8" "580.3" "654.9" "591.2" "554.8" "580.3" "546.4" "572.3" "797.8" "650.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054198857384115692" "False" "High" "IsMasterProtein" "O14492" "SH2B adapter protein 2 OS=Homo sapiens OX=9606 GN=SH2B2 PE=1 SV=2" "0.000" "False" "54.341" "18" "9" "13" "8" "632" "67.7" "6.27" "53.13" "9" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00169, Pf08916" "10603" "ENSG00000160999" "SH2B2" "A0A0A0MTI2; A6ND74; O14492" "Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling" "5" "1" "1.143" "1.024" "1.132" "1.061" "1.101" "1.004" "1.060" "1.029" "1.134" "754.5" "862.5" "773.0" "853.9" "800.8" "831.1" "757.2" "799.9" "776.8" "855.7" "" "" "" "" "" "" "" "" "" "" "606.0" "622.4" "614.0" "572.1" "553.8" "623.6" "530.1" "584.2" "776.8" "695.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4094952149974440381" "False" "High" "IsMasterProtein" "Q9H3P2" "Negative elongation factor A OS=Homo sapiens OX=9606 GN=NELFA PE=1 SV=3" "0.000" "False" "54.322" "22" "8" "13" "8" "528" "57.2" "9.03" "56.28" "8" "other biological processes" "cytosol;nucleus" "other molecular function" "" "7469" "ENSG00000185049" "NELFA" "A2A2T1; hsa:7469; O95392; Q9H3P2" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "16" "0" "1.026" "0.995" "1.027" "1.032" "1.028" "0.923" "1.053" "1.028" "0.985" "1089.3" "1117.6" "1083.5" "1118.4" "1124.3" "1120.0" "1005.9" "1147.1" "1119.4" "1073.4" "" "" "" "" "" "" "" "" "" "" "874.9" "806.4" "860.6" "749.3" "777.6" "840.3" "704.3" "837.7" "1119.4" "873.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5223570774126061662" "False" "High" "IsMasterProtein" "Q9UKA4" "A-kinase anchor protein 11 OS=Homo sapiens OX=9606 GN=AKAP11 PE=1 SV=1" "0.000" "False" "54.238" "7" "11" "11" "11" "1901" "210.4" "5.39" "41.90" "11" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "11215" "ENSG00000023516" "AKAP11" "hsa:11215; O75124; Q9NUK7; Q9UKA4" "" "G protein signaling pathways" "1" "0" "1.033" "0.963" "1.024" "1.027" "0.959" "1.020" "1.023" "1.054" "1.061" "568.2" "587.2" "547.1" "581.8" "583.6" "544.9" "579.4" "581.1" "599.1" "602.8" "" "" "" "" "" "" "" "" "" "" "456.4" "423.7" "434.5" "389.8" "403.6" "408.8" "405.7" "424.4" "599.1" "490.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "291264612704325176" "False" "High" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "0.000" "False" "54.149" "22" "8" "11" "8" "434" "46.7" "4.42" "44.31" "8" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF" "Nucleotide-binding oligomerization domain (NOD) pathway" "5" "0" "0.973" "0.960" "0.974" "0.949" "0.935" "0.923" "0.948" "0.986" "0.930" "1410.5" "1373.0" "1354.7" "1373.8" "1339.1" "1319.3" "1301.3" "1337.7" "1390.3" "1311.8" "" "" "" "" "" "" "" "" "" "" "1132.9" "990.7" "1076.1" "920.4" "926.1" "989.9" "911.1" "976.9" "1390.3" "1066.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8950408743700017704" "False" "High" "IsMasterProtein" "O60645" "Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3" "0.000" "False" "54.112" "18" "12" "13" "12" "745" "85.5" "6.29" "47.18" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06046" "11336" "ENSG00000180104" "EXOC3" "hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "1.022" "0.990" "0.993" "0.937" "1.013" "0.963" "1.021" "1.004" "0.988" "868.5" "887.3" "859.7" "862.0" "813.4" "879.5" "836.7" "886.6" "871.5" "858.2" "" "" "" "" "" "" "" "" "" "" "697.6" "640.2" "682.9" "577.6" "562.5" "659.9" "585.8" "647.5" "871.5" "698.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583521273813264514" "False" "High" "IsMasterProtein" "P35236" "Tyrosine-protein phosphatase non-receptor type 7 OS=Homo sapiens OX=9606 GN=PTPN7 PE=1 SV=3" "0.000" "False" "53.975" "34" "10" "11" "10" "360" "40.5" "6.79" "42.51" "10" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5778" "ENSG00000143851" "PTPN7" "B3KXE1; hsa:5778; P35236; Q53XK4; Q5SXQ0; Q5SXQ1; Q9BV05" "Interleukin-37 signaling; Negative regulation of MAPK pathway" "MAPK signaling pathway; IL-18 signaling pathway" "4" "0" "1.119" "0.956" "1.178" "1.036" "1.069" "1.022" "1.037" "0.988" "1.014" "435.7" "487.5" "416.5" "513.4" "451.6" "465.6" "445.4" "451.6" "430.4" "442.0" "" "" "" "" "" "" "" "" "" "" "349.9" "351.8" "330.9" "343.9" "312.3" "349.3" "311.8" "329.8" "430.4" "359.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1487358643357756863" "False" "High" "IsMasterProtein" "P41214" "Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3" "0.000" "False" "53.957" "26" "12" "16" "12" "584" "64.7" "7.65" "44.38" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01253, Pf17832" "1939" "ENSG00000143486" "EIF2D" "hsa:1939; P41214; Q5SY40; Q8IXV3; Q96DG3; Q96TG7; Q9NR27; Q9NSN0; Q9NV18; Q9NZ21" "" "" "0" "0" "0.938" "0.986" "1.123" "0.988" "0.939" "1.044" "0.963" "0.965" "0.983" "814.4" "764.3" "802.9" "915.0" "804.3" "765.0" "850.0" "784.3" "786.2" "800.6" "" "" "" "" "" "" "" "" "" "" "654.2" "551.5" "637.7" "613.0" "556.3" "574.0" "595.1" "572.8" "786.2" "651.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208996323542288612" "False" "High" "IsMasterProtein" "Q8N5P1" "Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2" "0.000" "False" "53.934" "34" "8" "11" "8" "291" "33.6" "8.28" "43.07" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18345" "84524" "ENSG00000144161" "ZC3H8" "hsa:84524; Q8N5P1; Q9BZ75" "RNA polymerase II transcribes snRNA genes" "2q13 copy number variation syndrome" "2" "0" "1.048" "1.086" "1.039" "1.022" "1.064" "1.050" "1.044" "0.997" "1.083" "1301.3" "1363.5" "1413.5" "1352.3" "1329.7" "1384.5" "1366.4" "1358.9" "1297.2" "1409.0" "" "" "" "" "" "" "" "" "" "" "1045.2" "983.8" "1122.8" "906.0" "919.7" "1038.8" "956.6" "992.4" "1297.2" "1145.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2566135857611723126" "False" "High" "IsMasterProtein" "P23743" "Diacylglycerol kinase alpha OS=Homo sapiens OX=9606 GN=DGKA PE=1 SV=3" "0.000" "False" "53.867" "20" "13" "18" "13" "735" "82.6" "6.73" "50.98" "13" "other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00130, Pf00609, Pf00781, Pf14513" "1606" "ENSG00000065357" "DGKA" "hsa:1606; O75481; O75482; O75483; O95217; P23743; Q3ZE25; Q8IZ56; Q8N5Q2" "Effects of PIP2 hydrolysis" "Modulators of TCR signaling and T cell activation" "2" "0" "1.009" "1.016" "1.089" "1.055" "1.024" "1.034" "1.042" "0.990" "1.003" "1098.8" "1108.8" "1116.0" "1196.7" "1158.8" "1125.0" "1136.7" "1145.1" "1087.8" "1102.5" "" "" "" "" "" "" "" "" "" "" "882.6" "800.1" "886.4" "801.8" "801.4" "844.1" "795.9" "836.3" "1087.8" "896.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "687508345564059484" "False" "High" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "0.000" "False" "53.775" "19" "13" "18" "11" "765" "86.1" "7.08" "58.39" "13" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "1.039" "0.980" "1.142" "1.076" "1.012" "1.035" "1.031" "1.073" "1.072" "664.0" "689.9" "650.6" "758.0" "714.3" "671.7" "687.3" "684.5" "712.7" "712.0" "" "" "" "" "" "" "" "" "" "" "533.3" "497.8" "516.8" "507.9" "494.0" "504.0" "481.2" "499.9" "712.7" "579.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6087199310060456450" "False" "High" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "0.000" "False" "53.769" "59" "6" "14" "6" "125" "14.2" "5.26" "53.24" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "tRNA modification in the nucleus and cytosol; Methylation; rRNA modification in the nucleus and cytosol; Eukaryotic Translation Termination" "" "4" "0" "1.022" "1.027" "1.133" "1.083" "1.063" "1.086" "0.991" "0.968" "0.983" "1026.2" "1048.8" "1053.8" "1163.0" "1110.9" "1090.7" "1114.0" "1017.4" "992.9" "1008.4" "" "" "" "" "" "" "" "" "" "" "824.2" "756.8" "837.1" "779.2" "768.3" "818.3" "780.0" "743.0" "992.9" "820.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8211975543562738760" "False" "High" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "0.000" "False" "53.701" "45" "11" "16" "11" "249" "28.4" "9.23" "55.65" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "Eukaryotic transcription initiation" "33" "0" "0.943" "1.010" "0.959" "0.958" "0.995" "0.938" "0.996" "0.990" "1.032" "1531.0" "1444.0" "1546.4" "1468.0" "1466.0" "1524.0" "1435.7" "1525.4" "1515.8" "1579.4" "" "" "" "" "" "" "" "" "" "" "1229.7" "1042.0" "1228.3" "983.6" "1013.9" "1143.5" "1005.2" "1114.0" "1515.8" "1284.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9034564449228548140" "False" "High" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "0.000" "False" "53.659" "41" "7" "14" "7" "188" "21.0" "5.14" "52.06" "7" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "Glutathione synthesis and recycling" "" "1" "0" "0.908" "0.931" "0.876" "0.943" "0.962" "0.932" "1.005" "0.979" "0.906" "1981.1" "1798.6" "1845.0" "1734.6" "1868.6" "1905.4" "1847.3" "1991.5" "1939.2" "1795.3" "" "" "" "" "" "" "" "" "" "" "1591.2" "1297.8" "1465.6" "1162.2" "1292.4" "1429.6" "1293.4" "1454.4" "1939.2" "1460.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1274747088330592999" "False" "High" "IsMasterProtein" "O94973" "AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2" "0.000" "False" "53.647" "12" "10" "14" "4" "939" "103.9" "6.96" "48.19" "10" "transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02296, Pf02883" "161" "ENSG00000183020" "AP2A2" "hsa:161; O75403; O94973; Q53ET1; Q96SI8" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "18" "0" "0.999" "0.967" "0.999" "1.119" "1.059" "1.063" "1.050" "0.984" "1.071" "525.6" "525.2" "508.3" "524.8" "588.1" "556.4" "558.9" "552.0" "517.2" "563.2" "" "" "" "" "" "" "" "" "" "" "422.2" "379.0" "403.7" "351.6" "406.7" "417.5" "391.3" "403.1" "517.2" "458.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3377056009907556172" "False" "High" "IsMasterProtein" "O14745" "Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=NHERF1 PE=1 SV=4" "0.000" "False" "53.574" "35" "10" "14" "10" "358" "38.8" "5.77" "51.04" "10" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf00595, Pf09007" "9368" "ENSG00000109062" "NHERF1" "B3KY21; hsa:9368; O14745; O43552; Q86WQ5" "" "TAR syndrome" "1" "0" "1.024" "0.985" "1.138" "1.035" "1.111" "1.159" "1.016" "1.119" "1.082" "906.6" "928.7" "892.6" "1031.5" "938.3" "1007.4" "1050.8" "921.4" "1014.5" "981.2" "" "" "" "" "" "" "" "" "" "" "728.1" "670.2" "709.0" "691.1" "648.9" "755.8" "735.7" "672.9" "1014.5" "798.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5010086175827698668" "False" "High" "IsMasterProtein" "P42575" "Caspase-2 OS=Homo sapiens OX=9606 GN=CASP2 PE=1 SV=2" "0.000" "False" "53.553" "29" "10" "13" "10" "452" "50.7" "6.81" "40.68" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00619, Pf00656" "835" "ENSG00000106144" "CASP2" "A8K5F9; D3DXD6; E9PDN0; hsa:835; P42575; P42576; Q59F21; Q7KZL6; Q86UJ3; Q9BUP7; Q9BZK9; Q9BZL0" "TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling" "Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis" "8" "0" "1.002" "1.006" "1.003" "0.963" "0.965" "1.020" "1.070" "1.026" "1.068" "796.0" "797.8" "800.6" "798.3" "766.5" "768.5" "811.7" "852.0" "816.6" "850.0" "" "" "" "" "" "" "" "" "" "" "639.3" "575.7" "636.0" "534.9" "530.1" "576.6" "568.3" "622.2" "816.6" "691.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "315483607845859686" "False" "High" "IsMasterProtein" "Q9BRF8" "Serine/threonine-protein phosphatase CPPED1 OS=Homo sapiens OX=9606 GN=CPPED1 PE=1 SV=3" "0.000" "False" "53.499" "33" "8" "10" "8" "314" "35.5" "6.20" "41.16" "8" "" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf00149" "55313" "ENSG00000103381" "CPPED1" "B4DQ68; hsa:55313; Q6MZY9; Q9BRF8; Q9H9M9; Q9NUT6" "Neutrophil degranulation" "" "1" "0" "1.000" "0.974" "0.982" "0.948" "0.987" "0.945" "0.851" "0.999" "1.002" "726.5" "726.8" "707.9" "713.3" "689.1" "717.0" "686.6" "618.3" "725.5" "728.0" "" "" "" "" "" "" "" "" "" "" "583.5" "524.4" "562.3" "477.9" "476.6" "538.0" "480.7" "451.6" "725.5" "592.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363881983208351205" "False" "High" "IsMasterProtein" "Q15438" "Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1" "0.000" "False" "53.484" "20" "7" "11" "5" "398" "46.4" "5.54" "34.62" "7" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9267" "ENSG00000108669" "CYTH1" "A6NFW7; B7Z1T4; hsa:9267; Q15438; Q9P123; Q9P124" "Intra-Golgi traffic" "2q37 copy number variation syndrome" "2" "2" "0.970" "0.975" "0.965" "1.020" "1.000" "0.980" "0.986" "0.981" "0.944" "1040.1" "1008.7" "1014.0" "1004.0" "1060.8" "1040.1" "1019.7" "1025.8" "1020.6" "981.3" "" "" "" "" "" "" "" "" "" "" "835.4" "727.8" "805.4" "672.7" "733.7" "780.4" "713.9" "749.1" "1020.6" "798.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660217191297362812" "False" "High" "IsMasterProtein" "P22695" "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3" "0.000" "False" "53.454" "32" "12" "14" "12" "453" "48.4" "8.63" "52.29" "12" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00675, Pf05193" "7385" "ENSG00000140740" "UQCRC2" "B3KSN4; hsa:7385; P22695; Q9BQ05" "Mitochondrial protein degradation; Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "5" "0" "1.029" "1.036" "1.035" "0.996" "0.954" "0.947" "1.048" "1.050" "1.018" "1283.4" "1320.2" "1330.1" "1328.6" "1278.4" "1224.1" "1215.8" "1345.1" "1347.5" "1306.8" "" "" "" "" "" "" "" "" "" "" "1030.8" "952.6" "1056.6" "890.2" "884.1" "918.4" "851.2" "982.3" "1347.5" "1062.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990414283188081585" "False" "High" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "0.000" "False" "53.447" "20" "9" "10" "9" "514" "57.2" "9.17" "41.58" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.114" "1.068" "1.077" "0.955" "1.066" "0.964" "0.969" "0.975" "1.030" "960.3" "1070.3" "1025.5" "1034.6" "916.9" "1023.5" "925.5" "930.3" "936.1" "989.3" "" "" "" "" "" "" "" "" "" "" "771.3" "772.3" "814.6" "693.2" "634.2" "767.9" "648.0" "679.4" "936.1" "804.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6180191668945880169" "False" "High" "IsMasterProtein" "Q9H269" "Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2" "0.000" "False" "53.441" "13" "9" "10" "9" "839" "94.6" "6.77" "36.34" "9" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04840, Pf04841" "64601" "ENSG00000215305" "VPS16" "hsa:64601; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5; Q9H269" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "3" "0" "1.060" "1.021" "1.063" "1.104" "1.062" "1.079" "1.132" "1.132" "1.117" "786.6" "833.9" "803.4" "836.1" "868.2" "835.6" "848.6" "890.5" "890.1" "878.9" "" "" "" "" "" "" "" "" "" "" "631.8" "601.7" "638.1" "560.2" "600.4" "627.0" "594.2" "650.3" "890.1" "714.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "467994795181612484" "False" "High" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "0.000" "False" "53.431" "6" "13" "14" "9" "2442" "265.2" "8.53" "42.38" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; O00147; Q16376; Q4LE28; Q92793" "Heme signaling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Transcriptional regulation of white adipocyte differentiation; SUMOylation of transcription cofactors; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Zygotic genome activation (ZGA); PPARA activates gene expression; NPAS4 regulates expression of target genes; Formation of the beta-catenin:TCF transactivating complex; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; Rubinstein-Taybi syndrome 1; 15q11q13 copy number variation; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "74" "0" "0.970" "0.912" "1.000" "0.993" "0.893" "0.973" "1.003" "0.939" "0.976" "507.9" "492.8" "463.2" "507.9" "504.4" "453.7" "494.1" "509.2" "477.0" "495.5" "" "" "" "" "" "" "" "" "" "" "407.9" "355.6" "367.9" "340.3" "348.8" "340.4" "345.9" "371.9" "477.0" "402.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1319936172901890664" "False" "High" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "0.000" "False" "53.408" "52" "9" "16" "8" "191" "22.2" "5.86" "45.62" "9" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "Factors involved in megakaryocyte development and platelet production; SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6" "Effect of progerin on genes involved in progeria; 22q11.2 copy number variation syndrome" "5" "0" "1.035" "1.076" "1.082" "1.106" "1.201" "1.179" "1.065" "1.067" "1.103" "1218.8" "1261.8" "1311.2" "1318.4" "1348.2" "1463.8" "1436.4" "1297.5" "1301.0" "1344.3" "" "" "" "" "" "" "" "" "" "" "978.9" "910.5" "1041.6" "883.3" "932.5" "1098.3" "1005.7" "947.6" "1301.0" "1093.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6631585726403495176" "False" "High" "IsMasterProtein" "O14787" "Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2 PE=1 SV=3" "0.000" "False" "53.407" "13" "9" "15" "5" "897" "101.3" "5.01" "44.00" "9" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf03810" "30000" "ENSG00000105576" "TNPO2" "hsa:30000; O14655; O14787; Q6IN77" "" "" "0" "0" "0.998" "0.957" "0.951" "0.992" "0.989" "1.015" "1.020" "0.934" "0.983" "371.4" "370.8" "355.5" "353.3" "368.5" "367.3" "377.2" "378.7" "346.8" "365.0" "" "" "" "" "" "" "" "" "" "" "298.3" "267.6" "282.4" "236.7" "254.8" "275.6" "264.1" "276.6" "346.8" "296.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8876035733125179295" "False" "High" "IsMasterProtein" "Q96D71" "RalBP1-associated Eps domain-containing protein 1 OS=Homo sapiens OX=9606 GN=REPS1 PE=1 SV=3" "0.000" "False" "53.356" "15" "9" "13" "9" "796" "86.6" "5.69" "44.68" "9" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "85021" "ENSG00000135597" "REPS1" "B7ZBZ8; B7ZBZ9; B7ZC00; hsa:85021; J3KP76; Q5JWJ5; Q5JWJ6; Q5JWJ7; Q8NDR7; Q8WU62; Q96D71; Q9BXY9" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "0.981" "1.012" "1.044" "1.044" "0.994" "1.020" "1.061" "1.055" "1.064" "1118.6" "1097.6" "1131.5" "1168.0" "1168.1" "1112.1" "1140.4" "1187.3" "1180.5" "1190.1" "" "" "" "" "" "" "" "" "" "" "898.4" "792.0" "898.8" "782.6" "807.9" "834.4" "798.5" "867.1" "1180.5" "967.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3076278996676727483" "False" "High" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "0.000" "False" "53.335" "23" "13" "16" "13" "603" "68.2" "8.91" "48.65" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Phosphorylation of Emi1; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Mitotic Telophase/Cytokinesis; Mitotic Metaphase/Anaphase Transition" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "30" "0" "1.082" "1.071" "1.035" "1.096" "1.072" "0.872" "0.914" "0.851" "1.008" "820.4" "887.6" "878.9" "849.3" "899.2" "879.9" "715.4" "749.5" "698.2" "827.1" "" "" "" "" "" "" "" "" "" "" "658.9" "640.4" "698.1" "569.0" "621.9" "660.2" "500.9" "547.4" "698.2" "672.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4926655616225133563" "False" "High" "IsMasterProtein" "Q86TI0" "TBC1 domain family member 1 OS=Homo sapiens OX=9606 GN=TBC1D1 PE=1 SV=2" "0.000" "False" "53.231" "14" "14" "15" "12" "1168" "133.0" "6.96" "44.27" "14" "" "nucleus" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "23216" "ENSG00000065882" "TBC1D1" "B7Z3D9; E9PGH8; hsa:23216; Q86TI0; Q96K82; Q9UPP4" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "2" "0" "1.078" "0.982" "1.065" "1.058" "1.005" "1.019" "1.104" "1.056" "1.078" "501.4" "540.3" "492.4" "533.8" "530.7" "503.9" "511.0" "553.6" "529.4" "540.6" "" "" "" "" "" "" "" "" "" "" "402.7" "389.8" "391.1" "357.7" "367.0" "378.1" "357.7" "404.3" "529.4" "439.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325736081283403068" "False" "High" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "0.000" "False" "53.229" "17" "7" "23" "5" "526" "53.4" "9.36" "76.14" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome; mRNA processing; HDAC6 interactions in the central nervous system" "5" "2" "1.088" "1.139" "1.082" "1.046" "1.122" "1.074" "1.049" "1.112" "1.071" "2926.6" "3185.6" "3334.8" "3166.5" "3062.7" "3284.9" "3144.5" "3071.0" "3255.4" "3134.9" "" "" "" "" "" "" "" "" "" "" "2350.6" "2298.6" "2648.9" "2121.6" "2118.2" "2464.6" "2201.6" "2242.8" "3255.4" "2549.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-309007205683403427" "False" "High" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "0.000" "False" "53.191" "37" "10" "15" "10" "365" "41.3" "8.68" "48.02" "10" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "" "Mesodermal commitment pathway" "1" "0" "1.088" "1.134" "1.054" "1.148" "1.101" "1.125" "1.065" "1.017" "1.078" "822.9" "895.1" "932.9" "867.1" "944.9" "906.3" "925.9" "876.0" "836.8" "887.1" "" "" "" "" "" "" "" "" "" "" "660.9" "645.9" "741.1" "581.0" "653.5" "680.0" "648.3" "639.7" "836.8" "721.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5706954355209209913" "False" "High" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "0.000" "False" "53.160" "36" "8" "21" "8" "277" "29.9" "7.68" "74.02" "8" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "ER-Phagosome pathway; Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "0.923" "0.948" "0.936" "0.956" "0.894" "0.943" "0.947" "0.926" "0.919" "2198.7" "2030.3" "2084.0" "2056.9" "2101.7" "1965.0" "2074.2" "2081.1" "2035.7" "2021.0" "" "" "" "" "" "" "" "" "" "" "1766.0" "1465.0" "1655.4" "1378.1" "1453.6" "1474.3" "1452.2" "1519.8" "2035.7" "1643.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4528933939237155494" "False" "High" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "0.000" "False" "53.053" "19" "8" "12" "8" "414" "44.7" "6.25" "50.29" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "8" "0" "1.023" "1.039" "1.029" "0.988" "1.007" "0.984" "1.013" "1.020" "1.027" "1497.6" "1531.6" "1556.0" "1540.8" "1480.1" "1508.1" "1474.3" "1517.6" "1527.7" "1538.6" "" "" "" "" "" "" "" "" "" "" "1202.8" "1105.2" "1236.0" "1032.3" "1023.6" "1131.5" "1032.2" "1108.3" "1527.7" "1251.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7065461624018501642" "False" "High" "IsMasterProtein" "Q96JB5" "CDK5 regulatory subunit-associated protein 3 OS=Homo sapiens OX=9606 GN=CDK5RAP3 PE=1 SV=2" "0.000" "False" "52.988" "21" "12" "13" "12" "506" "56.9" "4.75" "40.56" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05600" "80279" "ENSG00000108465" "CDK5RAP3" "B7Z6N4; D3DTU1; D3DTU2; F5H3I5; hsa:80279; Q53FA2; Q96JB5; Q9H3F8; Q9H8G0; Q9HBR9" "" "" "0" "0" "0.977" "0.937" "0.981" "0.979" "0.975" "1.057" "1.057" "1.035" "1.007" "1332.8" "1302.3" "1248.2" "1307.7" "1305.3" "1299.9" "1408.9" "1408.1" "1379.9" "1342.4" "" "" "" "" "" "" "" "" "" "" "1070.5" "939.7" "991.5" "876.2" "902.7" "975.3" "986.5" "1028.4" "1379.9" "1091.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962513167934133051" "False" "High" "IsMasterProtein" "P49643" "DNA primase large subunit OS=Homo sapiens OX=9606 GN=PRIM2 PE=1 SV=2" "0.000" "False" "52.981" "20" "9" "13" "9" "509" "58.8" "7.91" "50.93" "9" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04104" "5558" "ENSG00000146143" "PRIM2" "hsa:5558; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413" "Defective pyroptosis; Polymerase switching on the C-strand of the telomere; Polymerase switching; Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation; Removal of the Flap Intermediate" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "12" "0" "1.022" "1.017" "0.963" "1.027" "1.038" "0.891" "1.030" "1.033" "1.035" "1160.2" "1186.0" "1179.6" "1117.7" "1191.8" "1204.1" "1033.2" "1195.4" "1198.0" "1200.6" "" "" "" "" "" "" "" "" "" "" "931.9" "855.8" "937.0" "748.9" "824.2" "903.4" "723.4" "873.0" "1198.0" "976.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172314789071643693" "False" "High" "IsMasterProtein" "Q8IWV7" "E3 ubiquitin-protein ligase UBR1 OS=Homo sapiens OX=9606 GN=UBR1 PE=1 SV=1" "0.000" "False" "52.962" "9" "13" "15" "13" "1749" "200.1" "6.01" "44.90" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02207, Pf02617, Pf18995" "197131" "ENSG00000159459" "UBR1" "O60708; O75492; Q14D45; Q68DN9; Q8IWV7; Q8IWY6; Q96JY4" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.085" "0.966" "1.066" "1.091" "1.080" "1.029" "1.040" "1.065" "1.027" "1143.6" "1240.5" "1105.0" "1219.5" "1247.7" "1234.7" "1177.2" "1188.8" "1218.2" "1174.7" "" "" "" "" "" "" "" "" "" "" "918.5" "895.1" "877.8" "817.0" "862.9" "926.4" "824.2" "868.2" "1218.2" "955.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948996399981661341" "False" "High" "IsMasterProtein" "Q2TAL8" "Transcriptional regulator QRICH1 OS=Homo sapiens OX=9606 GN=QRICH1 PE=1 SV=1" "0.000" "False" "52.938" "12" "8" "12" "8" "776" "86.4" "5.87" "38.43" "8" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf12012" "54870" "ENSG00000198218" "QRICH1" "hsa:54870; Q2TAL8; Q4G0F7; Q7L621; Q8TEA5" "" "" "0" "0" "1.010" "0.961" "0.931" "0.950" "0.945" "0.872" "0.990" "0.980" "0.996" "916.7" "926.1" "880.8" "853.2" "870.9" "866.0" "799.5" "907.3" "898.4" "913.0" "" "" "" "" "" "" "" "" "" "" "736.3" "668.3" "699.7" "571.7" "602.3" "649.7" "559.8" "662.6" "898.4" "742.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4534983152498971383" "False" "High" "IsMasterProtein" "Q8N4C6" "Ninein OS=Homo sapiens OX=9606 GN=NIN PE=1 SV=4" "0.000" "False" "52.930" "5" "9" "10" "9" "2090" "243.1" "5.03" "38.51" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "51199" "ENSG00000100503" "NIN" "A6NDB8; B7WPA3; C9JSB6; C9JSG2; C9JXL2; hsa:51199; Q5BKU3; Q6P0P6; Q8N4C6; Q9BWU6; Q9C012; Q9C013; Q9C014; Q9H5I6; Q9HAT7; Q9HBY5; Q9HCK7; Q9UH61" "" "" "0" "0" "1.111" "1.133" "1.033" "1.085" "1.127" "1.046" "1.097" "1.089" "1.124" "592.3" "658.1" "671.1" "611.8" "642.7" "667.8" "619.4" "650.1" "645.3" "666.0" "" "" "" "" "" "" "" "" "" "" "475.7" "474.9" "533.1" "409.9" "444.5" "501.1" "433.6" "474.7" "645.3" "541.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700726988884900620" "False" "High" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "0.000" "False" "52.929" "39" "5" "14" "5" "176" "18.4" "9.44" "48.79" "5" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "1.121" "1.011" "1.132" "1.097" "1.070" "1.062" "1.116" "1.081" "1.080" "839.6" "940.9" "848.5" "950.7" "921.4" "898.4" "891.7" "937.0" "907.3" "907.1" "" "" "" "" "" "" "" "" "" "" "674.4" "678.9" "674.0" "637.0" "637.2" "674.1" "624.3" "684.3" "907.3" "737.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3715797868298302435" "False" "High" "IsMasterProtein" "Q5ST30" "Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2" "0.000" "False" "52.928" "13" "10" "11" "10" "1063" "118.4" "7.02" "37.35" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00133, Pf08264" "57176" "ENSG00000137411; ENSG00000223494" "VARS2" "A2ABL7; B4DET4; B4E3P5; F5GXJ0; F5H323; hsa:57176; Q2M2A0; Q59FI1; Q5SQ96; Q5SS98; Q5ST30; Q6DKJ5; Q6ZV24; Q96GN2; Q96H77; Q96Q02; Q9H6R2; Q9UFH7" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.063" "1.059" "1.041" "1.030" "1.061" "1.015" "1.059" "1.058" "1.050" "353.0" "375.3" "373.9" "367.4" "363.6" "374.5" "358.2" "373.8" "373.6" "370.7" "" "" "" "" "" "" "" "" "" "" "283.5" "270.8" "297.0" "246.1" "251.5" "281.0" "250.8" "273.0" "373.6" "301.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2194368294587715280" "False" "High" "IsMasterProtein" "Q16513" "Serine/threonine-protein kinase N2 OS=Homo sapiens OX=9606 GN=PKN2 PE=1 SV=1" "0.000" "False" "52.912" "14" "13" "15" "10" "984" "112.0" "6.30" "45.16" "13" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5586" "ENSG00000065243" "PKN2" "B4DQ21; B4DTP5; B4DVG1; D3DT24; hsa:5586; Q08AF4; Q16513; Q9H1W4" "RAC1 GTPase cycle; RHO GTPases activate PKNs; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "PI3K-Akt signaling pathway" "6" "0" "1.056" "0.978" "1.391" "1.217" "0.985" "1.472" "1.142" "0.962" "1.087" "844.5" "891.6" "825.9" "1175.0" "1027.6" "831.6" "1243.4" "964.4" "812.2" "918.2" "" "" "" "" "" "" "" "" "" "" "678.3" "643.3" "656.0" "787.3" "710.7" "623.9" "870.5" "704.3" "812.2" "746.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "692688187917917011" "False" "High" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "0.000" "False" "52.909" "40" "8" "18" "8" "210" "23.7" "6.42" "65.28" "8" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.047" "1.057" "1.101" "1.059" "1.047" "1.034" "1.079" "0.961" "1.016" "1883.8" "1973.3" "1990.3" "2074.1" "1995.6" "1972.3" "1948.3" "2032.2" "1810.3" "1913.8" "" "" "" "" "" "" "" "" "" "" "1513.1" "1423.9" "1580.9" "1389.6" "1380.1" "1479.8" "1364.1" "1484.2" "1810.3" "1556.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2463119363191037669" "False" "High" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "0.000" "False" "52.908" "15" "5" "9" "1" "453" "52.0" "6.39" "37.55" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "MASTL Facilitates Mitotic Progression" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "3" "0" "1.328" "0.864" "1.217" "1.087" "1.070" "1.122" "0.999" "1.054" "1.038" "135.3" "179.7" "116.9" "164.6" "147.0" "144.7" "151.8" "135.1" "142.6" "140.4" "" "" "" "" "" "" "" "" "" "" "108.6" "129.7" "92.8" "110.3" "101.7" "108.6" "106.3" "98.7" "142.6" "114.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-94552620576090045" "False" "High" "IsMasterProtein" "Q8IYM9" "E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1" "0.000" "False" "52.900" "29" "13" "17" "13" "498" "56.9" "7.72" "47.54" "13" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "10346" "ENSG00000132274" "TRIM22" "hsa:10346; Q05CQ0; Q15521; Q8IYM9" "Interferon gamma signaling" "" "1" "0" "1.002" "0.983" "1.044" "1.001" "1.048" "1.030" "1.042" "1.045" "1.105" "579.5" "580.8" "569.7" "604.8" "580.2" "607.4" "596.7" "603.8" "605.5" "640.1" "" "" "" "" "" "" "" "" "" "" "465.5" "419.1" "452.5" "405.2" "401.3" "455.7" "417.8" "441.0" "605.5" "520.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "714954485545523239" "False" "High" "IsMasterProtein" "P27986" "Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2" "0.000" "False" "52.887" "18" "13" "17" "9" "724" "83.5" "6.16" "51.71" "13" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5295" "ENSG00000145675" "PIK3R1" "B3KT19; D3DWA0; E7EX19; hsa:5295; P27986; Q15747; Q4VBZ7; Q53EM6; Q8IXA2; Q8N1C5" "G alpha (q) signalling events; Extra-nuclear estrogen signaling; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Downstream TCR signaling; RND2 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "154" "1" "1.028" "1.027" "1.071" "1.007" "1.021" "1.011" "1.009" "1.013" "1.055" "1065.1" "1094.8" "1093.7" "1141.0" "1072.2" "1087.5" "1076.9" "1074.7" "1078.8" "1124.0" "" "" "" "" "" "" "" "" "" "" "855.4" "790.0" "868.8" "764.4" "741.5" "815.9" "754.0" "784.8" "1078.8" "914.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3644173202538667698" "False" "High" "IsMasterProtein" "Q9Y4B6" "DDB1- and CUL4-associated factor 1 OS=Homo sapiens OX=9606 GN=DCAF1 PE=1 SV=3" "0.000" "False" "52.794" "10" "15" "18" "15" "1507" "168.9" "5.06" "52.29" "15" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "" "9730" "ENSG00000145041" "DCAF1" "hsa:9730; Q2YD74; Q8TBD9; Q9HCA1; Q9UG37; Q9Y4B6" "Antigen processing: Ubiquitination & Proteasome degradation" "Hippo-Merlin signaling dysregulation" "2" "0" "0.990" "0.994" "1.022" "0.930" "0.939" "0.966" "0.975" "0.964" "0.964" "1492.5" "1477.7" "1483.8" "1525.0" "1387.4" "1401.4" "1441.1" "1455.7" "1438.4" "1439.0" "" "" "" "" "" "" "" "" "" "" "1198.7" "1066.3" "1178.6" "1021.7" "959.5" "1051.5" "1009.0" "1063.1" "1438.4" "1170.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9136982351856623934" "False" "High" "IsMasterProtein" "P01861" "Immunoglobulin heavy constant gamma 4 OS=Homo sapiens OX=9606 GN=IGHG4 PE=1 SV=2" "0.000" "False" "52.749" "17" "5" "15" "5" "396" "43.8" "6.24" "61.98" "5" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07654" "" "ENSG00000211892; ENSG00000277016" "IGHG4" "A0A286YFJ8; P01861" "Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling" "" "9" "0" "0.947" "0.970" "0.919" "0.928" "0.941" "0.978" "0.947" "0.923" "0.918" "2019.3" "1912.6" "1958.5" "1855.9" "1874.6" "1900.6" "1975.0" "1912.4" "1864.1" "1854.1" "" "" "" "" "" "" "" "" "" "" "1621.9" "1380.1" "1555.7" "1243.4" "1296.5" "1426.0" "1382.8" "1396.6" "1864.1" "1507.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6653202710982051878" "False" "High" "IsMasterProtein" "Q96RL1" "BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2" "0.000" "False" "52.738" "23" "14" "15" "14" "719" "79.7" "5.45" "38.18" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18282" "51720" "ENSG00000087206" "UIMC1" "A8MSA1; B3KMZ1; B4E3N2; hsa:51720; Q5XKQ1; Q7Z3W7; Q8N5B9; Q96RL1; Q9BZR1; Q9BZR5; Q9UHX7" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "5q35 copy number variation" "6" "0" "1.009" "1.010" "1.063" "1.020" "1.018" "0.961" "1.033" "0.987" "1.010" "858.2" "866.1" "867.2" "912.5" "875.3" "874.1" "824.5" "886.3" "847.5" "867.0" "" "" "" "" "" "" "" "" "" "" "689.3" "625.0" "688.8" "611.3" "605.4" "655.8" "577.3" "647.3" "847.5" "705.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4758086446517534587" "False" "High" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "0.000" "False" "52.706" "62" "8" "22" "8" "118" "13.5" "9.91" "77.58" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "mRNA processing" "5" "0" "1.071" "1.117" "1.044" "1.006" "1.029" "0.996" "0.993" "1.060" "1.013" "2218.3" "2376.5" "2477.2" "2316.9" "2231.3" "2282.7" "2209.5" "2203.2" "2351.5" "2246.7" "" "" "" "" "" "" "" "" "" "" "1781.7" "1714.8" "1967.7" "1552.3" "1543.2" "1712.7" "1547.0" "1609.0" "2351.5" "1827.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830448209821531490" "False" "High" "IsMasterProtein" "Q9GZS3" "Superkiller complex protein 8 OS=Homo sapiens OX=9606 GN=SKIC8 PE=1 SV=1" "0.000" "False" "52.682" "26" "6" "10" "6" "305" "33.6" "5.47" "37.16" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; mRNA decay by 3' to 5' exoribonuclease" "" "5" "0" "1.000" "0.948" "0.994" "0.937" "0.924" "0.969" "0.957" "0.921" "0.952" "652.0" "652.3" "618.0" "648.2" "610.7" "602.5" "631.5" "624.2" "600.5" "620.8" "" "" "" "" "" "" "" "" "" "" "523.7" "470.7" "490.9" "434.3" "422.3" "452.0" "442.2" "455.9" "600.5" "504.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375658416039081200" "False" "High" "IsMasterProtein" "Q9GZU8" "PSME3-interacting protein OS=Homo sapiens OX=9606 GN=PSME3IP1 PE=1 SV=1" "0.000" "False" "52.569" "38" "10" "16" "10" "254" "28.9" "5.45" "51.19" "10" "other biological processes" "nucleus;other cell component" "" "Pf10187" "80011" "ENSG00000172775" "PSME3IP1" "hsa:80011; Q9GZU8" "" "" "0" "0" "1.038" "1.088" "1.067" "1.002" "1.023" "0.975" "1.019" "0.967" "0.994" "1912.9" "1985.6" "2082.0" "2040.8" "1917.2" "1957.2" "1865.3" "1949.0" "1848.8" "1901.1" "" "" "" "" "" "" "" "" "" "" "1536.4" "1432.7" "1653.8" "1367.3" "1326.0" "1468.4" "1306.0" "1423.4" "1848.8" "1546.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "576551174696518957" "False" "High" "IsMasterProtein" "Q5T447" "E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1" "0.000" "False" "52.486" "10" "7" "9" "7" "861" "97.1" "5.64" "35.64" "7" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632, Pf03256" "79654" "ENSG00000126107" "HECTD3" "B3KPV7; B3KRH4; hsa:79654; Q5T447; Q5T448; Q9H783" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.159" "1.064" "1.165" "1.080" "1.054" "1.042" "1.047" "1.074" "1.115" "489.9" "567.8" "521.0" "570.9" "529.1" "516.5" "510.5" "513.0" "526.0" "546.2" "" "" "" "" "" "" "" "" "" "" "393.5" "409.7" "413.9" "382.5" "365.9" "387.5" "357.4" "374.6" "526.0" "444.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1329067276742603011" "False" "High" "IsMasterProtein" "Q8WYP5" "Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3" "0.000" "False" "52.450" "5" "8" "8" "8" "2266" "252.3" "6.60" "29.99" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf13934, Pf16687" "25909" "ENSG00000153207" "AHCTF1" "A6NGM0; A8MSG9; A8MZ86; hsa:25909; Q7Z4E3; Q8IZA4; Q8WYP5; Q96EH9; Q9Y4Q6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "Gastric cancer network 2" "8" "0" "1.063" "1.035" "1.091" "1.117" "1.124" "1.154" "1.213" "1.167" "1.108" "421.4" "448.1" "436.1" "459.7" "470.9" "473.9" "486.4" "511.2" "491.6" "467.1" "" "" "" "" "" "" "" "" "" "" "338.5" "323.3" "346.4" "308.0" "325.7" "355.6" "340.6" "373.3" "491.6" "379.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454366493935613494" "False" "High" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "0.000" "False" "52.416" "34" "7" "13" "7" "249" "27.4" "8.06" "41.15" "7" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.984" "0.986" "1.099" "1.064" "1.103" "1.034" "1.010" "1.001" "1.095" "791.2" "778.3" "780.2" "869.5" "842.1" "872.7" "818.3" "798.9" "791.7" "866.2" "" "" "" "" "" "" "" "" "" "" "635.5" "561.6" "619.7" "582.6" "582.4" "654.8" "572.9" "583.4" "791.7" "704.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3983981062552353097" "False" "High" "IsMasterProtein" "Q92600" "CCR4-NOT transcription complex subunit 9 OS=Homo sapiens OX=9606 GN=CNOT9 PE=1 SV=1" "0.000" "False" "52.414" "29" "7" "12" "7" "299" "33.6" "8.03" "45.01" "7" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04078" "9125" "ENSG00000144580" "CNOT9" "B2RPI0; B5MDQ4; B7Z1E5; hsa:9125; Q92600; Q96IX4" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "4" "0" "1.057" "1.110" "1.212" "1.093" "1.120" "1.105" "1.024" "0.969" "1.093" "271.6" "287.1" "301.6" "329.2" "297.0" "304.3" "300.1" "278.3" "263.3" "296.8" "" "" "" "" "" "" "" "" "" "" "218.2" "207.1" "239.6" "220.6" "205.4" "228.3" "210.1" "203.2" "263.3" "241.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-720179637671099041" "False" "High" "IsMasterProtein" "Q06546" "GA-binding protein alpha chain OS=Homo sapiens OX=9606 GN=GABPA PE=1 SV=1" "0.000" "False" "52.366" "27" "9" "11" "9" "454" "51.3" "4.97" "42.30" "9" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf11620" "2551" "ENSG00000154727" "GABPA" "hsa:2551; Q06546; Q12939" "Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Pleural mesothelioma" "7" "0" "1.113" "1.096" "1.069" "1.162" "1.061" "1.075" "1.061" "1.041" "1.133" "562.9" "626.5" "616.7" "601.9" "654.0" "597.1" "605.0" "597.5" "586.1" "637.6" "" "" "" "" "" "" "" "" "" "" "452.1" "452.1" "489.9" "403.2" "452.3" "448.0" "423.6" "436.3" "586.1" "518.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8127348192762311520" "False" "High" "IsMasterProtein" "Q96HN2" "Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1" "0.000" "False" "52.358" "19" "13" "24" "4" "611" "66.7" "7.36" "76.82" "13" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00670, Pf05221" "23382" "ENSG00000158467" "AHCYL2" "B4DIZ5; D9N155; hsa:23382; O94917; Q96HN2" "Bicarbonate transporters" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Spina bifida" "4" "0" "0.993" "1.041" "1.024" "0.931" "0.998" "0.974" "1.007" "0.973" "0.979" "368.4" "365.7" "383.6" "377.2" "343.1" "367.5" "358.8" "370.9" "358.4" "360.6" "" "" "" "" "" "" "" "" "" "" "295.9" "263.9" "304.7" "252.7" "237.3" "275.7" "251.2" "270.9" "358.4" "293.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7103280702382610433" "False" "High" "IsMasterProtein" "Q8IX90" "Spindle and kinetochore-associated protein 3 OS=Homo sapiens OX=9606 GN=SKA3 PE=1 SV=2" "0.000" "False" "52.350" "27" "9" "11" "9" "412" "46.3" "5.11" "36.96" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "" "221150" "ENSG00000165480" "SKA3" "A2A330; A2A331; B2RBY2; hsa:221150; Q5VZV5; Q86WR2; Q8IX90; Q8NBG1; Q96D22" "" "" "0" "0" "0.925" "0.964" "0.936" "0.956" "0.946" "1.040" "1.068" "1.063" "1.024" "557.0" "515.0" "536.8" "521.3" "532.3" "526.8" "579.5" "595.0" "591.8" "570.5" "" "" "" "" "" "" "" "" "" "" "447.4" "371.6" "426.4" "349.3" "368.1" "395.2" "405.7" "434.5" "591.8" "464.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3369989001081277177" "False" "High" "IsMasterProtein" "Q96CN9" "GRIP and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GCC1 PE=1 SV=1" "0.000" "False" "52.348" "19" "16" "16" "16" "775" "87.8" "5.45" "48.82" "16" "" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01465" "79571" "ENSG00000179562" "GCC1" "hsa:79571; Q96CN9; Q9H6N7" "Retrograde transport at the Trans-Golgi-Network" "Nuclear receptors meta-pathway" "2" "0" "1.002" "0.956" "0.991" "1.012" "0.955" "0.964" "0.969" "1.024" "1.015" "1022.1" "1023.8" "977.2" "1013.4" "1034.9" "976.0" "984.9" "990.9" "1047.0" "1037.6" "" "" "" "" "" "" "" "" "" "" "821.0" "738.7" "776.2" "679.0" "715.7" "732.3" "689.6" "723.7" "1047.0" "843.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869916031675078190" "False" "High" "IsMasterProtein" "O95486" "Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2" "0.000" "False" "52.327" "12" "12" "16" "10" "1093" "119.7" "7.66" "42.68" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10802" "ENSG00000113615" "SEC24A" "A8MVW3; hsa:10802; O95486; Q8WUV2; Q96GP7" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "1" "1.056" "1.011" "1.042" "1.034" "1.041" "1.012" "0.989" "1.013" "0.995" "503.0" "531.4" "508.4" "524.3" "520.2" "523.6" "509.1" "497.3" "509.6" "500.6" "" "" "" "" "" "" "" "" "" "" "404.0" "383.4" "403.8" "351.3" "359.8" "392.8" "356.4" "363.2" "509.6" "407.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3984777124948273039" "False" "High" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "0.000" "False" "52.252" "33" "8" "16" "8" "275" "30.3" "7.50" "53.51" "8" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "O94903; Q6FI94" "" "" "0" "0" "1.036" "1.092" "1.001" "1.087" "1.106" "1.030" "1.041" "1.072" "1.067" "837.1" "867.3" "914.5" "838.0" "909.8" "926.1" "861.9" "871.8" "897.3" "893.2" "" "" "" "" "" "" "" "" "" "" "672.4" "625.8" "726.4" "561.5" "629.2" "694.8" "603.4" "636.6" "897.3" "726.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144980634344963458" "False" "High" "IsMasterProtein" "O14686" "Histone-lysine N-methyltransferase 2D OS=Homo sapiens OX=9606 GN=KMT2D PE=1 SV=2" "0.000" "False" "52.244" "3" "11" "12" "11" "5537" "593.0" "5.58" "35.80" "11" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "8085" "ENSG00000167548" "KMT2D" "hsa:8085; O14686; O14687" "Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Histone modifications; 16p11.2 proximal deletion syndrome" "8" "0" "1.106" "1.061" "1.038" "1.092" "1.016" "1.036" "1.038" "1.092" "1.041" "462.6" "511.6" "490.8" "480.3" "505.0" "470.2" "479.3" "480.0" "505.2" "481.7" "" "" "" "" "" "" "" "" "" "" "371.6" "369.1" "389.8" "321.8" "349.3" "352.8" "335.6" "350.5" "505.2" "391.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7069915122482910766" "False" "High" "IsMasterProtein" "Q9Y2I7" "1-phosphatidylinositol 3-phosphate 5-kinase OS=Homo sapiens OX=9606 GN=PIKFYVE PE=1 SV=3" "0.000" "False" "52.238" "6" "11" "12" "11" "2098" "237.0" "6.70" "35.32" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00118, Pf00610, Pf01363, Pf01504" "200576" "ENSG00000115020" "PIKFYVE" "hsa:200576; Q08AR7; Q08AR8; Q53ST3; Q53T36; Q8N5H0; Q8NB67; Q9Y2I7" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "1.037" "1.041" "0.988" "0.995" "1.044" "0.929" "0.973" "1.006" "1.039" "716.6" "743.0" "746.1" "708.3" "712.7" "748.1" "666.0" "697.2" "720.7" "744.9" "" "" "" "" "" "" "" "" "" "" "575.6" "536.1" "592.7" "474.6" "492.9" "561.3" "466.3" "509.2" "720.7" "605.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3878380865412542485" "False" "High" "IsMasterProtein" "Q96G01" "Protein bicaudal D homolog 1 OS=Homo sapiens OX=9606 GN=BICD1 PE=1 SV=3" "0.000" "False" "52.155" "10" "9" "11" "7" "975" "110.7" "5.81" "38.73" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf09730" "636" "ENSG00000151746" "BICD1" "A8K2C3; F8W113; hsa:636; O43892; O43893; Q96G01" "COPI-independent Golgi-to-ER retrograde traffic" "" "1" "0" "1.062" "1.006" "1.048" "1.075" "1.026" "1.125" "1.074" "1.009" "1.217" "125.2" "132.9" "125.9" "131.2" "134.5" "128.4" "140.8" "134.4" "126.3" "152.3" "" "" "" "" "" "" "" "" "" "" "100.5" "95.9" "100.0" "87.9" "93.0" "96.3" "98.6" "98.2" "126.3" "123.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276719871576654886" "False" "High" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "0.000" "False" "52.119" "25" "9" "13" "9" "476" "52.2" "6.15" "40.71" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394; ENSG00000292204" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.089" "1.095" "1.118" "1.086" "0.982" "1.021" "1.003" "1.036" "1.083" "503.6" "548.4" "551.6" "563.1" "546.8" "494.6" "514.3" "505.0" "521.5" "545.2" "" "" "" "" "" "" "" "" "" "" "404.5" "395.7" "438.2" "377.3" "378.2" "371.1" "360.1" "368.8" "521.5" "443.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8978349436204480078" "False" "High" "IsMasterProtein" "Q13148" "TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1" "0.000" "False" "52.111" "20" "7" "19" "7" "414" "44.7" "6.19" "59.98" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf18694, Pf20910" "23435" "ENSG00000120948" "TARDBP" "A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0" "" "MECP2 and associated Rett syndrome; HDAC6 interactions in the central nervous system" "2" "0" "1.004" "0.996" "0.979" "0.997" "0.924" "0.921" "0.989" "0.963" "0.976" "2181.7" "2190.6" "2172.4" "2136.3" "2174.8" "2016.9" "2008.3" "2158.0" "2101.6" "2128.8" "" "" "" "" "" "" "" "" "" "" "1752.4" "1580.7" "1725.6" "1431.3" "1504.1" "1513.2" "1406.1" "1576.0" "2101.6" "1731.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084755087725056383" "False" "High" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "0.000" "False" "52.081" "14" "14" "16" "9" "1023" "112.8" "5.49" "52.93" "14" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "6" "1" "1.026" "0.982" "1.148" "1.298" "1.172" "1.640" "1.086" "1.352" "1.194" "766.2" "785.8" "752.3" "879.3" "994.8" "898.1" "1256.9" "832.2" "1035.9" "915.0" "" "" "" "" "" "" "" "" "" "" "615.4" "567.0" "597.6" "589.1" "688.0" "673.9" "880.0" "607.8" "1035.9" "744.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2662746858814386989" "False" "High" "IsMasterProtein" "Q15024" "Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3" "0.000" "False" "52.065" "29" "8" "11" "8" "291" "31.8" "5.19" "42.84" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "23016" "ENSG00000075914" "EXOSC7" "hsa:23016; Q15024; Q96E72" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.089" "1.021" "1.067" "1.072" "1.116" "1.052" "1.093" "1.085" "1.057" "958.9" "1043.9" "978.7" "1023.1" "1028.3" "1070.4" "1008.3" "1048.1" "1040.1" "1013.8" "" "" "" "" "" "" "" "" "" "" "770.2" "753.2" "777.4" "685.4" "711.2" "803.1" "706.0" "765.4" "1040.1" "824.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2890677899884632439" "False" "High" "IsMasterProtein" "Q01201" "Transcription factor RelB OS=Homo sapiens OX=9606 GN=RELB PE=1 SV=2" "0.000" "False" "52.050" "23" "11" "14" "11" "579" "62.1" "6.24" "44.56" "11" "stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179, Pf16180, Pf16181" "5971" "ENSG00000104856" "RELB" "hsa:5971; Q01201; Q6GTX7; Q9UEI7" "CD209 (DC-SIGN) signaling; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; EDA signaling in hair follicle development; Ebola virus infection in host; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Osteoarthritic chondrocyte hypertrophy" "14" "0" "1.026" "1.018" "1.114" "1.042" "0.923" "1.022" "1.055" "1.058" "1.061" "704.7" "723.1" "717.2" "785.3" "734.0" "650.7" "720.2" "743.1" "745.9" "747.4" "" "" "" "" "" "" "" "" "" "" "566.0" "521.8" "569.7" "526.1" "507.6" "488.2" "504.3" "542.7" "745.9" "607.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4023730213020721894" "False" "High" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "0.000" "False" "52.029" "22" "8" "11" "8" "485" "53.3" "7.34" "43.18" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "" "17q12 copy number variation syndrome" "1" "0" "1.035" "0.991" "0.947" "0.947" "1.235" "0.908" "0.945" "0.981" "1.073" "887.4" "918.9" "879.7" "840.2" "840.6" "1095.8" "805.8" "838.4" "870.5" "952.4" "" "" "" "" "" "" "" "" "" "" "712.7" "663.0" "698.8" "562.9" "581.4" "822.2" "564.2" "612.3" "870.5" "774.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624689202228352756" "False" "High" "IsMasterProtein" "Q8IWJ2" "GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4" "0.000" "False" "52.026" "8" "13" "13" "13" "1684" "195.8" "5.14" "41.42" "13" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01465, Pf16704" "9648" "ENSG00000135968" "GCC2" "A6H8X8; hsa:9648; O15045; Q4ZG46; Q8IWJ2; Q8TDH3; Q9H2G8" "Retrograde transport at the Trans-Golgi-Network; Signaling by ALK fusions and activated point mutants" "Deregulation of Rab and Rab effector genes in bladder cancer" "3" "0" "1.003" "1.023" "1.040" "1.006" "1.005" "0.963" "1.052" "1.021" "1.107" "573.0" "574.7" "586.4" "595.7" "576.2" "575.7" "552.0" "602.9" "585.2" "634.4" "" "" "" "" "" "" "" "" "" "" "460.2" "414.7" "465.8" "399.1" "398.5" "432.0" "386.5" "440.3" "585.2" "515.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8905060599663970094" "False" "High" "IsMasterProtein" "Q9Y5K8" "V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1" "0.000" "False" "52.026" "33" "5" "11" "5" "247" "28.2" "9.36" "40.62" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01813" "51382" "ENSG00000100554" "ATP6V1D" "B2RE33; hsa:51382; Q9Y5K8; Q9Y688" "Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "7" "0" "1.050" "1.005" "1.026" "0.969" "0.990" "0.875" "0.979" "0.962" "1.055" "697.6" "732.7" "701.1" "715.6" "675.7" "690.8" "610.1" "682.6" "671.3" "736.0" "" "" "" "" "" "" "" "" "" "" "560.3" "528.7" "556.9" "479.5" "467.3" "518.3" "427.2" "498.5" "671.3" "598.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314787517679089989" "False" "High" "IsMasterProtein" "Q8WUX9" "Charged multivesicular body protein 7 OS=Homo sapiens OX=9606 GN=CHMP7 PE=1 SV=1" "0.000" "False" "52.017" "21" "8" "13" "8" "453" "50.9" "5.35" "46.22" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "91782" "ENSG00000147457" "CHMP7" "B2RDT3; B4DKJ6; D3DSS1; hsa:91782; Q8NDM1; Q8WUX9; Q9BT50" "Late endosomal microautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "1.038" "1.015" "1.062" "1.030" "1.027" "0.929" "0.993" "1.015" "0.981" "907.8" "942.1" "921.8" "964.4" "935.4" "932.4" "843.4" "901.2" "921.6" "890.7" "" "" "" "" "" "" "" "" "" "" "729.1" "679.8" "732.2" "646.1" "646.9" "699.5" "590.5" "658.2" "921.6" "724.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9155703229501675198" "False" "High" "IsMasterProtein" "P31751" "RAC-beta serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT2 PE=1 SV=2" "0.000" "False" "51.984" "22" "9" "12" "8" "481" "55.7" "6.37" "38.98" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "208" "ENSG00000105221" "AKT2" "B2RBD8; hsa:208; P31751; Q05BV0; Q0VAN0; Q0VAN1; Q68GC0" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Regulation of TP53 Degradation; CTLA4 inhibitory signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Activation of AKT2; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; FLT3 Signaling; Negative regulation of the PI3K/AKT network; Regulation of TP53 Activity through Acetylation; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; PDE3B signalling; Inhibition of TSC complex formation by PKB" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; S1P receptor signal transduction; Cardiac hypertrophic response; Focal adhesion; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Acute myeloid leukemia; Sildenafil treatment; Female steroid hormones in cardiomyocyte energy metabolism; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; Artemisinin inhibition of uveal melanoma; ErbB signaling pathway; Toll-like receptor signaling pathway" "83" "1" "1.020" "0.982" "1.010" "0.961" "1.022" "0.920" "1.032" "1.043" "1.033" "899.4" "917.2" "883.1" "908.2" "864.2" "918.8" "827.7" "928.5" "937.9" "928.9" "" "" "" "" "" "" "" "" "" "" "722.4" "661.8" "701.5" "608.5" "597.7" "689.4" "579.5" "678.1" "937.9" "755.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710541814749781042" "False" "High" "IsMasterProtein" "P54619" "5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1" "0.000" "False" "51.971" "28" "8" "10" "8" "331" "37.6" "6.92" "33.91" "8" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00571" "5571" "ENSG00000181929" "PRKAG1" "B4DDT7; hsa:5571; P54619; Q8N7V9" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "24" "0" "1.043" "1.015" "1.006" "0.952" "1.021" "1.006" "1.085" "0.962" "0.998" "600.5" "626.2" "609.5" "604.3" "571.8" "613.4" "604.1" "651.9" "577.5" "599.6" "" "" "" "" "" "" "" "" "" "" "482.4" "451.9" "484.2" "404.9" "395.5" "460.2" "422.9" "476.0" "577.5" "487.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5805697236743296122" "False" "High" "IsMasterProtein" "Q96QU8" "Exportin-6 OS=Homo sapiens OX=9606 GN=XPO6 PE=1 SV=1" "0.000" "False" "51.845" "10" "12" "14" "12" "1125" "128.8" "6.35" "47.27" "12" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03810, Pf08389" "23214" "ENSG00000169180" "XPO6" "A1L3W4; D3DWF9; hsa:23214; Q2YDX3; Q53G88; Q68G50; Q76N88; Q96CP8; Q96QU8; Q9BT21" "" "" "0" "0" "1.053" "1.023" "1.004" "1.010" "0.988" "0.854" "1.009" "0.946" "1.020" "933.5" "983.1" "955.3" "936.9" "942.9" "922.5" "797.5" "942.0" "883.5" "952.1" "" "" "" "" "" "" "" "" "" "" "749.8" "709.4" "758.8" "627.7" "652.1" "692.1" "558.4" "688.0" "883.5" "774.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4306142825200876867" "False" "High" "IsMasterProtein" "P11766" "Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4" "0.000" "False" "51.800" "30" "10" "20" "10" "374" "39.7" "7.49" "53.61" "10" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00107, Pf08240" "128" "ENSG00000197894" "ADH5" "hsa:128; P11766; Q6FHR2" "Ethanol oxidation" "Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism" "3" "0" "0.959" "0.969" "0.922" "0.974" "1.043" "0.971" "0.997" "0.980" "0.962" "1830.8" "1755.0" "1773.4" "1688.1" "1782.7" "1909.6" "1777.9" "1826.1" "1793.6" "1760.4" "" "" "" "" "" "" "" "" "" "" "1470.5" "1266.4" "1408.7" "1131.0" "1232.9" "1432.7" "1244.8" "1333.6" "1793.6" "1431.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "52020500018808800" "False" "High" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "0.000" "False" "51.751" "44" "8" "22" "8" "170" "18.7" "5.03" "64.15" "8" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "1.017" "0.957" "1.065" "1.068" "1.048" "1.044" "1.021" "0.982" "1.040" "978.3" "995.2" "936.5" "1041.6" "1044.3" "1025.1" "1021.4" "998.7" "960.4" "1017.6" "" "" "" "" "" "" "" "" "" "" "785.7" "718.1" "743.9" "697.9" "722.3" "769.1" "715.1" "729.4" "960.4" "827.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3767865638315377274" "False" "High" "IsMasterProtein" "O60684" "Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1" "0.000" "False" "51.746" "19" "9" "15" "4" "536" "60.0" "4.98" "52.41" "9" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "23633" "ENSG00000025800" "KPNA6" "B2RDC7; D3DPP5; hsa:23633; O60684; Q5VVU3" "Assembly of the ORC complex at the origin of replication" "" "1" "0" "0.976" "0.892" "0.998" "1.003" "1.026" "1.039" "0.936" "1.018" "1.029" "269.2" "262.6" "240.1" "268.5" "269.9" "276.2" "279.5" "251.9" "273.9" "277.0" "" "" "" "" "" "" "" "" "" "" "216.2" "189.5" "190.7" "179.9" "186.7" "207.2" "195.7" "184.0" "273.9" "225.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516272036315922492" "False" "High" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "0.000" "False" "51.746" "16" "8" "20" "8" "639" "68.3" "8.98" "64.76" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "mRNA Splicing - Major Pathway" "" "1" "0" "0.976" "0.992" "1.090" "1.064" "1.045" "1.118" "1.020" "1.041" "1.035" "1253.9" "1224.1" "1244.0" "1367.2" "1334.0" "1310.7" "1401.9" "1279.3" "1304.7" "1298.2" "" "" "" "" "" "" "" "" "" "" "1007.1" "883.2" "988.1" "916.0" "922.6" "983.4" "981.6" "934.3" "1304.7" "1055.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739284738644474323" "False" "High" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "0.000" "False" "51.738" "16" "10" "15" "8" "689" "79.5" "7.28" "48.44" "10" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis; Calmodulin induced events" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway; HDAC6 interactions in the central nervous system" "9" "1" "0.984" "0.966" "0.976" "1.006" "0.919" "0.931" "0.963" "1.022" "1.010" "1123.7" "1105.3" "1085.1" "1097.0" "1130.6" "1032.8" "1045.8" "1081.6" "1148.7" "1135.2" "" "" "" "" "" "" "" "" "" "" "902.5" "797.5" "861.9" "735.0" "781.9" "774.9" "732.2" "789.9" "1148.7" "923.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7820543804174258540" "False" "High" "IsMasterProtein" "P00374" "Dihydrofolate reductase OS=Homo sapiens OX=9606 GN=DHFR PE=1 SV=2" "0.000" "False" "51.717" "51" "9" "24" "9" "187" "21.4" "7.42" "71.71" "9" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00186" "1719" "ENSG00000228716" "DHFR" "B4DDD2; hsa:1719; P00374; Q14130; Q6IRW8" "G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; Ethanol effects on histone modifications" "9" "0" "0.988" "0.980" "1.006" "0.974" "0.997" "1.129" "1.084" "1.141" "1.017" "2346.2" "2317.3" "2298.5" "2359.7" "2286.3" "2340.1" "2648.2" "2544.1" "2677.8" "2385.6" "" "" "" "" "" "" "" "" "" "" "1884.4" "1672.1" "1825.8" "1581.0" "1581.3" "1755.7" "1854.2" "1857.9" "2677.8" "1940.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9106014466644302785" "False" "High" "IsMasterProtein" "Q9Y5Q8" "General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2" "0.000" "False" "51.628" "28" "13" "14" "13" "519" "59.5" "6.90" "44.04" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09734, Pf17682" "9328" "ENSG00000148308" "GTF3C5" "A6NI44; A6NJB9; hsa:9328; Q5T7U2; Q5T7U3; Q8N2U7; Q8N857; Q96GD9; Q9H4P2; Q9Y5Q8" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "1.078" "1.024" "1.070" "1.044" "1.045" "1.017" "1.118" "1.074" "1.062" "669.6" "721.5" "685.4" "716.7" "699.3" "699.8" "680.6" "748.6" "718.9" "711.4" "" "" "" "" "" "" "" "" "" "" "537.8" "520.6" "544.4" "480.2" "483.6" "525.0" "476.6" "546.7" "718.9" "578.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9207268972416967358" "False" "High" "IsMasterProtein" "O15066" "Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1" "0.000" "False" "51.568" "19" "12" "17" "11" "747" "85.1" "7.69" "43.89" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9371" "ENSG00000101350" "KIF3B" "B2RMP4; B4DSR5; E1P5M5; hsa:9371; O15066" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins" "" "5" "0" "0.993" "1.005" "0.995" "0.941" "0.971" "0.963" "1.009" "0.958" "0.985" "872.8" "866.6" "877.5" "868.7" "820.9" "847.9" "840.4" "880.7" "836.5" "859.7" "" "" "" "" "" "" "" "" "" "" "701.0" "625.3" "697.0" "582.0" "567.8" "636.2" "588.4" "643.2" "836.5" "699.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7302016058410828571" "False" "High" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "0.000" "False" "51.548" "25" "4" "7" "4" "238" "26.7" "7.24" "30.68" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "mRNA Splicing - Major Pathway" "" "1" "0" "1.261" "1.203" "1.226" "1.119" "1.117" "1.152" "1.214" "1.207" "1.091" "619.6" "781.1" "745.2" "759.4" "693.6" "692.1" "714.0" "752.1" "747.6" "675.8" "" "" "" "" "" "" "" "" "" "" "497.7" "563.6" "592.0" "508.8" "479.7" "519.3" "499.9" "549.3" "747.6" "549.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5117695276373963239" "False" "High" "IsMasterProtein" "Q9UKL0" "REST corepressor 1 OS=Homo sapiens OX=9606 GN=RCOR1 PE=1 SV=2" "0.000" "False" "51.532" "24" "10" "17" "8" "485" "53.3" "7.03" "61.14" "10" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "23186" "ENSG00000089902" "RCOR1" "hsa:23186; J3KN32; Q15044; Q6P2I9; Q86VG5; Q9UKL0" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production" "" "4" "1" "0.988" "0.948" "1.002" "0.946" "1.008" "0.972" "0.962" "0.918" "0.996" "1024.8" "1012.4" "971.1" "1027.3" "969.9" "1033.2" "995.6" "986.2" "941.3" "1020.5" "" "" "" "" "" "" "" "" "" "" "823.1" "730.5" "771.4" "688.3" "670.8" "775.2" "697.1" "720.2" "941.3" "829.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4632135778776149030" "False" "High" "IsMasterProtein" "P18085" "ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3" "0.000" "False" "51.530" "56" "9" "17" "5" "180" "20.5" "7.14" "53.18" "9" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00025" "378" "ENSG00000168374" "ARF4" "B2R7J7; hsa:378; P18085; P21371" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; VxPx cargo-targeting to cilium" "VEGFA-VEGFR2 signaling" "4" "3" "1.062" "1.013" "1.012" "1.039" "1.066" "0.933" "1.034" "1.003" "1.016" "1596.0" "1694.3" "1616.9" "1615.4" "1658.7" "1701.1" "1489.2" "1649.7" "1600.2" "1620.8" "" "" "" "" "" "" "" "" "" "" "1281.9" "1222.5" "1284.4" "1082.3" "1147.2" "1276.3" "1042.6" "1204.8" "1600.2" "1318.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8919089648667332764" "False" "High" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "0.000" "False" "51.521" "21" "11" "12" "11" "707" "78.5" "4.87" "43.37" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "1.010" "0.966" "1.015" "1.025" "0.974" "0.990" "0.973" "0.984" "1.015" "1286.7" "1299.2" "1243.1" "1305.9" "1319.4" "1252.9" "1274.1" "1252.2" "1266.5" "1306.0" "" "" "" "" "" "" "" "" "" "" "1033.5" "937.5" "987.4" "875.0" "912.5" "940.0" "892.0" "914.5" "1266.5" "1062.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2794156240078795368" "False" "High" "IsMasterProtein" "Q8NEZ5" "F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1" "0.000" "False" "51.512" "21" "7" "9" "7" "403" "44.5" "7.03" "35.99" "7" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00646, Pf10442" "26263" "ENSG00000167196" "FBXO22" "hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.051" "0.985" "1.046" "1.111" "0.972" "1.070" "1.029" "0.983" "1.062" "806.9" "847.7" "795.1" "844.0" "896.8" "784.7" "863.0" "830.3" "793.0" "857.3" "" "" "" "" "" "" "" "" "" "" "648.1" "611.7" "631.6" "565.5" "620.2" "588.7" "604.2" "606.4" "793.0" "697.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546315403352841289" "False" "High" "IsMasterProtein" "Q9Y2B0" "Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1" "0.000" "False" "51.452" "43" "6" "14" "6" "182" "20.6" "4.92" "46.64" "6" "other biological processes" "ER/Golgi" "" "Pf11938" "10330" "ENSG00000257727" "CNPY2" "B2R7B9; Q9UHE9; Q9Y2B0" "" "" "0" "0" "1.060" "1.020" "1.015" "0.996" "1.066" "1.054" "1.093" "1.076" "1.022" "1049.2" "1111.9" "1070.0" "1065.4" "1045.5" "1118.0" "1105.5" "1147.0" "1129.2" "1072.4" "" "" "" "" "" "" "" "" "" "" "842.7" "802.3" "849.9" "713.8" "723.1" "838.8" "774.0" "837.6" "1129.2" "872.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8250639024737902778" "False" "High" "IsMasterProtein" "O14727" "Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2" "0.000" "False" "51.423" "11" "15" "16" "14" "1248" "141.7" "6.40" "48.86" "15" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00619, Pf00931, Pf17908, Pf21296" "317" "ENSG00000120868" "APAF1" "B2RMX8; hsa:317; O14727; O43297; Q7Z438; Q9BXZ6; Q9UBZ5; Q9UGN8; Q9UGN9; Q9UGP0; Q9UJ58; Q9UJ59; Q9UJ60; Q9UJ61; Q9UJ62; Q9UJ63; Q9UJ64; Q9UJ65; Q9UJ66; Q9UJ67; Q9UNC9" "Neutrophil degranulation; Transcriptional Regulation by E2F6; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity" "miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "28" "0" "1.016" "1.026" "1.014" "0.982" "1.054" "0.993" "0.976" "1.016" "0.992" "635.7" "645.8" "652.4" "644.6" "624.1" "670.2" "631.2" "620.4" "645.9" "630.8" "" "" "" "" "" "" "" "" "" "" "510.6" "466.0" "518.2" "431.9" "431.6" "502.8" "441.9" "453.1" "645.9" "513.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4024286234021820395" "False" "High" "IsMasterProtein" "P78406" "mRNA export factor RAE1 OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "0.000" "False" "51.409" "23" "7" "12" "7" "368" "40.9" "7.83" "40.96" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Transcriptional regulation by small RNAs; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of HSF1-mediated heat shock response; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "30" "0" "1.046" "0.997" "0.922" "1.028" "1.064" "1.025" "1.052" "1.045" "1.077" "783.7" "819.8" "781.5" "722.7" "805.5" "833.5" "803.3" "824.8" "818.7" "844.5" "" "" "" "" "" "" "" "" "" "" "629.5" "591.6" "620.8" "484.2" "557.1" "625.4" "562.5" "602.4" "818.7" "686.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "508361359361041752" "False" "High" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "0.000" "False" "51.390" "36" "4" "15" "4" "183" "20.3" "4.72" "56.75" "4" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "0.977" "0.946" "0.957" "0.967" "0.993" "0.933" "1.016" "0.960" "0.999" "1482.8" "1449.3" "1403.1" "1419.7" "1434.5" "1473.0" "1383.5" "1507.0" "1423.6" "1481.8" "" "" "" "" "" "" "" "" "" "" "1191.0" "1045.8" "1114.5" "951.2" "992.1" "1105.1" "968.6" "1100.6" "1423.6" "1205.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3870745537767616027" "False" "High" "IsMasterProtein" "Q9UKT9" "Zinc finger protein Aiolos OS=Homo sapiens OX=9606 GN=IKZF3 PE=1 SV=2" "0.000" "False" "51.385" "28" "12" "16" "8" "509" "58.0" "6.55" "54.42" "12" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "22806" "ENSG00000161405" "IKZF3" "B4DVV5; hsa:22806; Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2; Q69BM3; Q69BM5; Q8N574; Q8WWQ9; Q8WWR0; Q8WWR1; Q8WWR2; Q8WWR3; Q9UKT9" "" "17q12 copy number variation syndrome" "1" "0" "1.025" "1.093" "0.980" "1.068" "1.154" "1.063" "1.193" "1.203" "1.092" "1056.3" "1083.0" "1154.7" "1035.0" "1128.3" "1218.8" "1122.3" "1259.9" "1271.1" "1153.6" "" "" "" "" "" "" "" "" "" "" "848.4" "781.5" "917.2" "693.5" "780.3" "914.4" "785.8" "920.1" "1271.1" "938.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3427598645898203721" "False" "High" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "0.000" "False" "51.337" "17" "4" "8" "4" "347" "38.3" "7.64" "35.14" "4" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "1.019" "0.903" "1.014" "1.070" "1.061" "1.017" "1.013" "0.992" "1.025" "368.4" "375.5" "332.7" "373.5" "394.0" "390.9" "374.5" "373.3" "365.4" "377.6" "" "" "" "" "" "" "" "" "" "" "295.9" "271.0" "264.3" "250.3" "272.5" "293.3" "262.2" "272.6" "365.4" "307.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3347831162215749093" "False" "High" "IsMasterProtein" "Q9UEW8" "STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3" "0.000" "False" "51.294" "21" "9" "14" "6" "545" "59.4" "6.29" "48.04" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "27347" "ENSG00000198648" "STK39" "O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; Q9UEW8; X5D9C8" "" "" "0" "0" "1.011" "0.995" "0.975" "0.932" "0.913" "0.906" "0.937" "0.958" "0.944" "894.5" "904.3" "890.3" "871.8" "833.4" "817.0" "810.7" "837.7" "856.9" "844.1" "" "" "" "" "" "" "" "" "" "" "718.4" "652.5" "707.2" "584.1" "576.4" "613.0" "567.6" "611.8" "856.9" "686.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2309568012740462624" "False" "High" "IsMasterProtein" "Q02750" "Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2" "0.000" "False" "51.259" "23" "8" "20" "5" "393" "43.4" "6.62" "63.65" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5604" "ENSG00000169032" "MAP2K1" "hsa:5604; Q02750" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAP3K8 (TPL2)-dependent MAPK1/3 activation; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "102" "0" "0.972" "0.938" "0.919" "0.924" "0.907" "0.870" "0.869" "0.892" "0.883" "859.9" "835.5" "806.4" "790.0" "794.4" "780.2" "748.0" "746.9" "766.8" "759.3" "" "" "" "" "" "" "" "" "" "" "690.6" "602.8" "640.6" "529.3" "549.4" "585.4" "523.7" "545.5" "766.8" "617.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5080369595642031285" "False" "High" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "0.000" "False" "51.208" "41" "9" "16" "9" "233" "26.0" "4.79" "57.53" "9" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "0.980" "1.002" "0.982" "0.985" "1.031" "0.972" "0.989" "0.980" "1.003" "1068.8" "1047.2" "1071.0" "1049.1" "1052.6" "1101.5" "1039.2" "1057.5" "1047.5" "1071.9" "" "" "" "" "" "" "" "" "" "" "858.4" "755.7" "850.7" "702.9" "728.0" "826.5" "727.6" "772.3" "1047.5" "871.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7198210632893501960" "False" "High" "IsMasterProtein" "Q07864" "DNA polymerase epsilon catalytic subunit A OS=Homo sapiens OX=9606 GN=POLE PE=1 SV=5" "0.000" "False" "51.167" "7" "14" "15" "14" "2286" "261.4" "6.39" "47.84" "14" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08490" "5426" "ENSG00000177084" "POLE" "hsa:5426; Q07864; Q13533; Q86VH9" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "19" "0" "1.037" "1.018" "1.107" "0.995" "1.017" "1.086" "1.059" "1.022" "1.089" "862.5" "894.7" "878.3" "955.1" "858.4" "877.5" "936.6" "913.6" "881.0" "939.4" "" "" "" "" "" "" "" "" "" "" "692.7" "645.6" "697.7" "639.9" "593.7" "658.4" "655.8" "667.2" "881.0" "764.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "410623999248744867" "False" "High" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "0.000" "False" "51.163" "12" "14" "20" "13" "1096" "123.4" "8.82" "59.16" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383, Pf21071" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "4" "0" "1.118" "1.150" "1.219" "1.196" "1.154" "1.279" "1.122" "1.208" "1.166" "519.1" "580.4" "597.1" "632.5" "620.9" "599.2" "663.8" "582.3" "626.9" "605.0" "" "" "" "" "" "" "" "" "" "" "416.9" "418.8" "474.3" "423.8" "429.4" "449.6" "464.7" "425.2" "626.9" "492.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008482199911470815" "False" "High" "IsMasterProtein" "O43516" "WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3" "0.000" "False" "51.162" "20" "9" "20" "9" "503" "51.2" "11.47" "62.47" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "7456" "ENSG00000115935" "WIPF1" "B8ZZM1; D3DPE4; hsa:7456; O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs" "" "5" "0" "1.001" "1.013" "1.078" "1.069" "1.092" "1.120" "1.059" "1.032" "1.060" "917.8" "918.9" "929.7" "989.4" "980.9" "1002.6" "1027.9" "971.5" "947.0" "973.1" "" "" "" "" "" "" "" "" "" "" "737.2" "663.1" "738.5" "662.9" "678.4" "752.2" "719.7" "709.5" "947.0" "791.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "588939397575272440" "False" "High" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "0.000" "False" "51.158" "21" "11" "14" "11" "689" "74.3" "9.57" "54.79" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "2" "0" "0.959" "0.942" "0.987" "0.951" "0.935" "0.936" "1.004" "0.944" "0.965" "892.2" "855.3" "840.7" "880.5" "848.5" "834.5" "834.7" "896.1" "842.0" "861.1" "" "" "" "" "" "" "" "" "" "" "716.6" "617.2" "667.8" "589.9" "586.8" "626.1" "584.4" "654.4" "842.0" "700.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "415707649714952015" "False" "High" "IsMasterProtein" "P38398" "Breast cancer type 1 susceptibility protein OS=Homo sapiens OX=9606 GN=BRCA1 PE=1 SV=2" "0.000" "False" "51.088" "7" "9" "9" "9" "1863" "207.6" "5.41" "33.42" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00097, Pf00533, Pf12820" "672" "ENSG00000012048" "BRCA1" "E9PFZ0; hsa:672; O15129; P38398; Q1RMC1; Q3LRJ0; Q3LRJ6; Q6IN79; Q7KYU9" "Meiotic synapsis; Resolution of D-loop Structures through Holliday Junction Intermediates; Neddylation; KEAP1-NFE2L2 pathway; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Transcriptional Regulation by E2F6; Metalloprotease DUBs; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Nonhomologous End-Joining (NHEJ); Defective DNA double strand break response due to BRCA1 loss of function; Defective DNA double strand break response due to BARD1 loss of function" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Glioblastoma signaling pathways; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; PI3K-Akt signaling pathway; Breast cancer pathway; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; 5q35 copy number variation; DNA damage response" "40" "0" "1.015" "0.995" "1.052" "1.021" "1.053" "0.996" "1.042" "1.080" "1.047" "1228.6" "1246.7" "1221.8" "1291.9" "1253.7" "1294.0" "1224.0" "1280.6" "1326.5" "1285.9" "" "" "" "" "" "" "" "" "" "" "986.8" "899.6" "970.5" "865.6" "867.1" "970.8" "857.0" "935.2" "1326.5" "1045.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6780722004559034825" "False" "High" "IsMasterProtein" "P35520" "Cystathionine beta-synthase OS=Homo sapiens OX=9606 GN=CBS PE=1 SV=2" "0.000" "False" "51.070" "21" "9" "13" "9" "551" "60.5" "6.65" "43.93" "9" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00291, Pf00571" "102724560; 875" "ENSG00000160200" "CBS" "B2R993; D3DSK4; hsa:102724560; hsa:875; P35520; Q99425; Q9BWC5" "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Vitamin D receptor pathway; Amino acid metabolism; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis; Ciliary landscape" "13" "0" "0.966" "0.996" "1.060" "0.972" "0.945" "0.983" "0.987" "0.957" "0.978" "1190.4" "1149.9" "1185.4" "1261.8" "1156.8" "1124.6" "1169.8" "1175.4" "1138.8" "1164.6" "" "" "" "" "" "" "" "" "" "" "956.1" "829.8" "941.6" "845.4" "800.0" "843.8" "819.1" "858.4" "1138.8" "947.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6767865713948388298" "False" "High" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "0.000" "False" "51.053" "32" "6" "22" "6" "205" "22.9" "6.55" "76.62" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.908" "1.002" "0.885" "1.016" "1.011" "0.940" "0.948" "0.898" "0.927" "1541.4" "1399.3" "1544.8" "1364.2" "1566.2" "1558.2" "1449.7" "1461.8" "1383.8" "1429.5" "" "" "" "" "" "" "" "" "" "" "1238.1" "1009.7" "1227.0" "914.0" "1083.2" "1169.1" "1015.0" "1067.5" "1383.8" "1162.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516016884332694472" "False" "High" "IsMasterProtein" "O60361" "Putative nucleoside diphosphate kinase OS=Homo sapiens OX=9606 GN=NME2P1 PE=5 SV=1" "0.000" "False" "51.045" "59" "7" "38" "1" "137" "15.5" "8.57" "123.89" "7" "other metabolic processes;other biological processes" "" "kinase activity;other molecular function" "Pf00334" "" "" "NME2P1" "O60361" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "0.862" "0.976" "0.859" "0.818" "0.894" "0.830" "0.738" "0.859" "0.849" "1055.2" "909.8" "1029.8" "906.4" "863.5" "943.4" "875.3" "778.3" "906.6" "895.6" "" "" "" "" "" "" "" "" "" "" "847.5" "656.5" "818.0" "607.3" "597.2" "707.8" "612.9" "568.4" "906.6" "728.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5470294891726501754" "False" "High" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "0.000" "False" "50.997" "31" "10" "16" "10" "342" "38.9" "5.52" "52.95" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "4" "0" "1.019" "0.973" "1.039" "1.018" "1.013" "0.973" "1.016" "1.012" "1.004" "1068.8" "1088.9" "1039.7" "1111.0" "1088.5" "1083.1" "1039.8" "1086.3" "1081.3" "1072.7" "" "" "" "" "" "" "" "" "" "" "858.5" "785.7" "825.9" "744.4" "752.8" "812.6" "728.0" "793.3" "1081.3" "872.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2604748441743257015" "False" "High" "IsMasterProtein" "Q6P1J9" "Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1" "0.000" "False" "50.984" "17" "10" "13" "10" "531" "60.5" "9.61" "45.25" "10" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05179, Pf16050" "79577" "ENSG00000134371" "CDC73" "A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7" "Hedgehog 'on' state; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex" "Endoderm differentiation" "7" "0" "0.975" "0.952" "0.986" "1.039" "0.972" "1.008" "1.032" "1.019" "1.018" "1312.5" "1279.5" "1249.7" "1293.9" "1363.3" "1275.4" "1323.5" "1354.6" "1337.8" "1335.7" "" "" "" "" "" "" "" "" "" "" "1054.2" "923.3" "992.6" "866.9" "942.8" "956.9" "926.6" "989.3" "1337.8" "1086.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4791788072284182717" "False" "High" "IsMasterProtein" "Q96GM5" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2" "0.000" "False" "50.886" "22" "11" "15" "9" "515" "58.2" "9.25" "47.24" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02201" "6602" "ENSG00000066117" "SMARCD1" "A6NN27; hsa:6602; Q92924; Q96GM5; Q9Y635" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "1.121" "1.039" "1.110" "1.063" "1.020" "1.022" "1.114" "1.124" "1.035" "766.8" "859.4" "796.7" "851.3" "814.9" "782.2" "783.4" "853.9" "862.1" "793.3" "" "" "" "" "" "" "" "" "" "" "615.9" "620.1" "632.9" "570.3" "563.6" "586.9" "548.5" "623.6" "862.1" "645.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4253585410806837271" "False" "High" "IsMasterProtein" "Q8TEU7" "Rap guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=RAPGEF6 PE=1 SV=2" "0.000" "False" "50.864" "8" "12" "15" "11" "1601" "179.3" "6.40" "43.28" "12" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf00595, Pf00617, Pf00618, Pf00788" "51735" "ENSG00000158987" "RAPGEF6" "A3KN82; A5PLL6; B7ZML2; E9PDV7; hsa:51735; Q8NI21; Q8TEU6; Q8TEU7; Q96PC1" "" "" "0" "0" "1.002" "0.977" "1.005" "1.022" "1.015" "0.951" "1.037" "1.051" "0.986" "953.2" "954.7" "931.2" "958.0" "973.7" "967.9" "906.3" "988.6" "1001.6" "940.2" "" "" "" "" "" "" "" "" "" "" "765.6" "688.9" "739.7" "641.9" "673.4" "726.2" "634.6" "722.0" "1001.6" "764.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8362369727593218523" "False" "High" "IsMasterProtein" "Cont_Q9Z2K1" "Keratin, type I cytoskeletal 16 OS=Mus musculus OX=10090 GN=Krt16 PE=1 SV=3" "0.000" "True" "50.829" "23" "10" "21" "1" "469" "51.6" "5.20" "53.48" "10" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "16666" "ENSMUSG00000053797" "Krt16" "mmu:16666; Q3SYP5; Q9Z2K1" "Formation of the cornified envelope" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412220755654312839" "False" "High" "IsMasterProtein" "Q15652" "Probable JmjC domain-containing histone demethylation protein 2C OS=Homo sapiens OX=9606 GN=JMJD1C PE=1 SV=2" "0.000" "False" "50.817" "5" "12" "13" "12" "2540" "284.3" "7.87" "47.31" "12" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "221037" "ENSG00000171988" "JMJD1C" "A0T124; hsa:221037; Q15652; Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7" "Factors involved in megakaryocyte development and platelet production" "Pathways affected in adenoid cystic carcinoma" "2" "0" "1.018" "0.976" "0.980" "0.934" "0.979" "0.814" "0.900" "0.962" "0.956" "937.3" "954.2" "915.1" "918.3" "875.0" "917.7" "763.3" "843.1" "901.3" "896.2" "" "" "" "" "" "" "" "" "" "" "752.8" "688.5" "726.9" "615.3" "605.2" "688.6" "534.4" "615.7" "901.3" "728.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396014057802155010" "False" "High" "IsMasterProtein" "Q15910" "Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens OX=9606 GN=EZH2 PE=1 SV=2" "0.000" "False" "50.809" "12" "7" "9" "7" "746" "85.3" "7.02" "35.61" "7" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf11616, Pf18118, Pf18264, Pf21358" "2146" "ENSG00000106462" "EZH2" "B2RAQ1; B3KS30; B7Z1D6; B7Z7L6; hsa:2146; Q15755; Q15910; Q75MG3; Q92857; Q96FI6" "Defective pyroptosis; Oxidative Stress Induced Senescence; HCMV Early Events; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "Cell differentiation - expanded index; Histone modifications; Endoderm differentiation; Interactome of polycomb repressive complex 2 (PRC2) ; MECP2 and associated Rett syndrome; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "19" "0" "1.013" "1.040" "1.030" "1.032" "1.047" "0.979" "1.058" "1.066" "1.020" "827.3" "838.0" "860.4" "851.7" "853.9" "866.0" "810.3" "875.2" "881.7" "843.6" "" "" "" "" "" "" "" "" "" "" "664.5" "604.7" "683.4" "570.7" "590.6" "649.8" "567.3" "639.1" "881.7" "686.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8434539253909675931" "False" "High" "IsMasterProtein" "Q13588" "GRB2-related adapter protein OS=Homo sapiens OX=9606 GN=GRAP PE=1 SV=1" "0.000" "False" "50.782" "47" "8" "16" "8" "217" "25.3" "7.03" "48.25" "8" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018" "10750" "ENSG00000154016" "GRAP" "hsa:10750; Q13588" "Signaling by SCF-KIT" "" "1" "0" "0.982" "1.007" "1.039" "0.998" "0.989" "0.926" "0.940" "0.923" "1.004" "1383.5" "1358.8" "1393.8" "1438.0" "1380.3" "1368.8" "1280.8" "1300.6" "1276.4" "1388.6" "" "" "" "" "" "" "" "" "" "" "1111.2" "980.5" "1107.1" "963.5" "954.7" "1027.0" "896.8" "949.8" "1276.4" "1129.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8256721828910616389" "False" "High" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "0.000" "False" "50.731" "8" "12" "12" "12" "1824" "206.7" "6.47" "42.69" "12" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "3" "0" "1.012" "0.986" "1.062" "1.050" "1.012" "1.010" "1.046" "1.088" "1.035" "823.2" "833.2" "811.4" "874.2" "864.7" "833.3" "831.4" "861.0" "895.8" "852.3" "" "" "" "" "" "" "" "" "" "" "661.2" "601.2" "644.6" "585.7" "598.0" "625.2" "582.1" "628.8" "895.8" "693.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2903433267102321467" "False" "High" "IsMasterProtein" "Q9UL03" "Integrator complex subunit 6 OS=Homo sapiens OX=9606 GN=INTS6 PE=1 SV=1" "0.000" "False" "50.724" "13" "11" "14" "11" "887" "100.3" "8.62" "43.86" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf13519, Pf15300" "26512" "ENSG00000102786" "INTS6" "hsa:26512; Q0P664; Q6PJP4; Q9UFK0; Q9UL03; Q9Y5M9" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.013" "1.048" "1.092" "1.098" "1.155" "1.122" "1.106" "1.142" "1.067" "463.2" "469.3" "485.5" "506.0" "508.8" "535.0" "519.5" "512.2" "528.9" "494.1" "" "" "" "" "" "" "" "" "" "" "372.1" "338.7" "385.6" "339.0" "351.9" "401.4" "363.7" "374.0" "528.9" "401.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295082137940750650" "False" "High" "IsMasterProtein" "O43633" "Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1" "0.000" "False" "50.694" "16" "4" "7" "4" "222" "25.1" "5.97" "32.28" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "27243" "ENSG00000130724" "CHMP2A" "B2R4W6; hsa:27243; O43633; Q3ZTT0" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "10" "0" "1.046" "0.986" "1.030" "1.058" "1.125" "1.014" "1.048" "1.052" "1.087" "482.9" "505.1" "476.1" "497.5" "511.0" "543.4" "489.6" "506.0" "508.0" "525.1" "" "" "" "" "" "" "" "" "" "" "387.9" "364.4" "378.2" "333.3" "353.4" "407.7" "342.8" "369.5" "508.0" "427.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6734575471453550747" "False" "High" "IsMasterProtein" "Q6FI81" "Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2" "0.000" "False" "50.686" "30" "10" "17" "10" "312" "33.6" "5.62" "51.62" "10" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05093, Pf20922" "57019" "ENSG00000005194" "CIAPIN1" "A8K8B6; hsa:57019; O75206; O75207; Q6FI81; Q9H0W1; Q9P1L7" "Cytosolic iron-sulfur cluster assembly" "" "1" "0" "0.973" "0.975" "0.943" "0.922" "0.945" "0.929" "0.905" "0.944" "0.931" "2419.1" "2354.8" "2358.0" "2280.7" "2230.2" "2286.8" "2247.5" "2190.0" "2283.1" "2253.0" "" "" "" "" "" "" "" "" "" "" "1943.0" "1699.1" "1873.1" "1528.0" "1542.4" "1715.8" "1573.6" "1599.4" "2283.1" "1832.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3251544276452061183" "False" "High" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "0.000" "False" "50.662" "27" "10" "13" "10" "475" "53.5" "9.09" "49.08" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "mRNA Splicing - Major Pathway; Protein hydroxylation; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates" "7" "0" "1.155" "1.248" "1.179" "1.142" "1.072" "1.025" "1.214" "1.115" "1.181" "822.0" "949.3" "1025.5" "969.2" "938.4" "881.3" "842.6" "997.6" "916.8" "971.0" "" "" "" "" "" "" "" "" "" "" "660.2" "685.0" "814.6" "649.3" "649.0" "661.2" "590.0" "728.6" "916.8" "789.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6326411103029325143" "False" "High" "IsMasterProtein" "P53602" "Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1" "0.000" "False" "50.614" "29" "11" "15" "11" "400" "43.4" "7.23" "49.80" "11" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00288, Pf18376" "4597" "ENSG00000167508" "MVD" "P53602; Q53Y65" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Synthesis of Dolichyl-phosphate" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Aspirin and miRNAs; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "11" "0" "0.978" "0.987" "1.007" "0.952" "0.946" "0.987" "0.974" "1.001" "1.013" "1701.4" "1664.6" "1678.5" "1714.1" "1619.8" "1610.1" "1678.5" "1656.7" "1703.6" "1723.7" "" "" "" "" "" "" "" "" "" "" "1366.6" "1201.2" "1333.3" "1148.5" "1120.3" "1208.1" "1175.2" "1209.9" "1703.6" "1401.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980726595472841033" "False" "High" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "0.000" "False" "50.614" "35" "10" "21" "7" "298" "33.9" "8.68" "60.44" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "CDK-mediated phosphorylation and removal of Cdc6; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "47" "0" "0.994" "1.001" "0.994" "0.971" "1.005" "1.102" "1.234" "1.137" "1.037" "803.7" "799.1" "804.7" "798.9" "780.3" "807.9" "885.3" "992.1" "913.6" "833.4" "" "" "" "" "" "" "" "" "" "" "645.5" "576.6" "639.2" "535.3" "539.7" "606.1" "619.9" "724.5" "913.6" "677.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7576876112341409561" "False" "High" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "0.000" "False" "50.570" "27" "9" "19" "9" "399" "45.3" "7.75" "60.99" "9" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "1.132" "1.022" "0.993" "0.965" "1.010" "0.936" "0.931" "0.954" "0.991" "1083.2" "1225.8" "1107.0" "1075.8" "1045.5" "1094.0" "1013.9" "1008.7" "1033.4" "1073.6" "" "" "" "" "" "" "" "" "" "" "870.0" "884.5" "879.3" "720.8" "723.1" "820.8" "709.9" "736.7" "1033.4" "873.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6920554993800994285" "False" "High" "IsMasterProtein" "Q02880" "DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3" "0.000" "False" "50.565" "7" "9" "10" "8" "1626" "183.2" "8.00" "35.50" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7155" "ENSG00000077097" "TOP2B" "hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8" "SUMOylation of DNA replication proteins" "" "1" "0" "0.992" "1.002" "1.066" "1.040" "1.049" "1.143" "1.069" "1.079" "1.035" "596.7" "592.1" "598.0" "635.9" "620.3" "625.9" "681.9" "638.1" "643.6" "617.7" "" "" "" "" "" "" "" "" "" "" "479.3" "427.2" "475.0" "426.1" "429.0" "469.6" "477.5" "466.0" "643.6" "502.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9007113237130658680" "False" "High" "IsMasterProtein" "O15498" "Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1" "0.000" "False" "50.542" "41" "8" "18" "8" "198" "22.4" "6.92" "56.11" "8" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "10652" "ENSG00000106636" "YKT6" "B4DR94; hsa:10652; O15498; Q53F01; Q6FGU9; Q6IB15" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport" "" "8" "0" "0.994" "0.986" "0.987" "0.904" "0.919" "0.968" "1.015" "1.011" "0.966" "2284.6" "2270.4" "2253.2" "2253.8" "2065.0" "2100.0" "2212.5" "2317.9" "2309.6" "2206.6" "" "" "" "" "" "" "" "" "" "" "1835.0" "1638.3" "1789.8" "1510.1" "1428.2" "1575.6" "1549.1" "1692.7" "2309.6" "1794.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7690147936594120282" "False" "High" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "0.000" "False" "50.416" "31" "10" "13" "10" "361" "39.3" "7.18" "47.51" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "0.960" "0.973" "1.009" "0.984" "0.958" "0.936" "0.940" "0.946" "0.980" "1404.4" "1347.6" "1367.1" "1416.5" "1381.6" "1344.9" "1314.3" "1319.5" "1328.9" "1376.4" "" "" "" "" "" "" "" "" "" "" "1128.0" "972.4" "1085.9" "949.1" "955.6" "1009.1" "920.2" "963.6" "1328.9" "1119.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5836561258245124912" "False" "High" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "0.000" "False" "50.379" "20" "7" "10" "7" "394" "44.2" "9.09" "39.28" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Reversal of alkylation damage by DNA dioxygenases" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.024" "0.957" "0.995" "0.997" "0.974" "0.985" "0.998" "1.041" "1.022" "707.8" "724.9" "677.4" "703.9" "706.0" "689.5" "696.9" "706.4" "736.8" "723.6" "" "" "" "" "" "" "" "" "" "" "568.5" "523.0" "538.0" "471.6" "488.3" "517.3" "487.9" "515.9" "736.8" "588.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1270194887050037302" "False" "High" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "0.000" "False" "50.262" "35" "8" "10" "8" "275" "30.3" "8.22" "39.74" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "Ciliary landscape" "5" "0" "0.965" "1.020" "0.996" "1.011" "0.922" "0.899" "0.975" "0.949" "0.924" "645.8" "623.2" "658.6" "643.3" "653.0" "595.7" "580.6" "629.4" "613.1" "596.9" "" "" "" "" "" "" "" "" "" "" "518.7" "449.7" "523.2" "431.0" "451.6" "446.9" "406.5" "459.7" "613.1" "485.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4634440829805379897" "False" "High" "IsMasterProtein" "Q02224" "Centromere-associated protein E OS=Homo sapiens OX=9606 GN=CENPE PE=1 SV=2" "0.000" "False" "50.261" "5" "14" "16" "13" "2701" "316.2" "5.64" "43.03" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "1062" "ENSG00000138778" "CENPE" "A6NKY9; A8K2U7; hsa:1062; Q02224; Q4LE75" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Regulation of sister chromatid separation at the metaphase-anaphase transition" "10" "0" "1.103" "0.989" "1.230" "1.077" "0.998" "0.970" "0.944" "0.904" "1.053" "971.4" "1071.6" "960.4" "1195.1" "1046.3" "969.2" "942.7" "916.8" "877.8" "1023.2" "" "" "" "" "" "" "" "" "" "" "780.2" "773.2" "762.9" "800.7" "723.6" "727.1" "660.0" "669.5" "877.8" "832.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570551838394526128" "False" "High" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "0.000" "False" "50.252" "33" "12" "15" "12" "386" "43.8" "7.20" "52.14" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "Network map of SARS-CoV-2 signaling pathway" "3" "0" "1.018" "0.949" "1.035" "1.056" "1.044" "1.047" "1.086" "1.014" "1.005" "1301.7" "1325.7" "1234.7" "1346.7" "1374.3" "1359.4" "1363.1" "1413.2" "1320.5" "1308.7" "" "" "" "" "" "" "" "" "" "" "1045.5" "956.6" "980.8" "902.3" "950.5" "1019.9" "954.4" "1032.1" "1320.5" "1064.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7324571001266765675" "False" "High" "IsMasterProtein" "P29350" "Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1" "0.000" "False" "50.206" "17" "9" "10" "9" "595" "67.5" "7.78" "37.14" "9" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00017, Pf00102" "5777" "ENSG00000111679" "PTPN6" "A8K306; G3V0F8; hsa:5777; P29350; Q969V8; Q9UK67" "Neutrophil degranulation; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PD-1 signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signal regulatory protein family interactions; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; Signaling by ALK; Regulation of KIT signaling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Interleukin-37 signaling; Platelet sensitization by LDL; PECAM1 interactions; Nuclear events stimulated by ALK signaling in cancer" "Prolactin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; IL-3 signaling pathway; Kit receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways" "33" "0" "0.987" "0.974" "0.917" "0.969" "0.969" "0.932" "0.944" "1.011" "0.966" "650.3" "642.0" "633.0" "596.1" "630.2" "629.9" "606.3" "614.1" "657.2" "628.2" "" "" "" "" "" "" "" "" "" "" "522.3" "463.3" "502.8" "399.4" "435.8" "472.6" "424.5" "448.4" "657.2" "510.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3053469202622973433" "False" "High" "IsMasterProtein" "Q7L591" "Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2" "0.000" "False" "50.200" "26" "11" "15" "11" "496" "53.3" "7.77" "48.86" "11" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf02174" "79930" "ENSG00000146094" "DOK3" "E9PAT0; H7BXS0; hsa:79930; Q7L591; Q8N864; Q9BQB3; Q9H666" "Neutrophil degranulation" "5q35 copy number variation" "2" "0" "1.008" "0.954" "1.071" "1.023" "0.950" "0.997" "0.957" "0.940" "0.987" "1155.4" "1164.8" "1102.5" "1236.9" "1182.4" "1098.1" "1151.5" "1105.4" "1086.3" "1140.2" "" "" "" "" "" "" "" "" "" "" "928.0" "840.5" "875.7" "828.8" "817.8" "823.9" "806.2" "807.3" "1086.3" "927.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9193943049168300683" "False" "High" "IsMasterProtein" "Q02818" "Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 PE=1 SV=4" "0.000" "False" "50.188" "30" "12" "13" "12" "461" "53.8" "5.25" "48.05" "12" "signal transduction" "ER/Golgi" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "" "4924" "ENSG00000104805" "NUCB1" "B2RD64; hsa:4924; Q02818; Q15838; Q7Z4J7; Q9BUR1" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "1.022" "1.029" "1.102" "1.117" "1.165" "1.176" "1.123" "1.221" "1.124" "1050.2" "1072.9" "1081.1" "1157.3" "1172.6" "1223.8" "1234.8" "1178.8" "1281.8" "1180.6" "" "" "" "" "" "" "" "" "" "" "843.5" "774.2" "858.7" "775.4" "811.0" "918.2" "864.6" "860.9" "1281.8" "960.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8034699390765478794" "False" "High" "IsMasterProtein" "Q9UID3" "Vacuolar protein sorting-associated protein 51 homolog OS=Homo sapiens OX=9606 GN=VPS51 PE=1 SV=2" "0.000" "False" "50.137" "16" "12" "15" "12" "782" "86.0" "6.47" "43.68" "12" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08700" "738" "ENSG00000149823" "VPS51" "hsa:738; Q6PJV5; Q7L8A6; Q8WZ35; Q96DF4; Q96GR3; Q9UID3" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.037" "0.963" "1.021" "1.038" "1.032" "1.018" "0.991" "0.949" "1.050" "446.9" "463.3" "430.6" "456.1" "463.7" "461.2" "454.8" "442.8" "424.1" "469.3" "" "" "" "" "" "" "" "" "" "" "358.9" "334.3" "342.0" "305.6" "320.7" "346.0" "318.5" "323.4" "424.1" "381.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3208600518816650541" "False" "High" "IsMasterProtein" "Q96IU4" "Putative protein-lysine deacylase ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1" "0.000" "False" "50.101" "43" "7" "13" "7" "210" "22.3" "6.40" "44.44" "7" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12697" "84836" "ENSG00000114779" "ABHD14B" "hsa:84836; Q86VK8; Q8N8W5; Q96IU4" "Cytosolic sulfonation of small molecules" "" "1" "0" "0.951" "0.986" "1.008" "1.049" "0.992" "1.007" "0.971" "1.006" "1.023" "501.6" "477.1" "494.8" "505.5" "526.1" "497.7" "505.3" "487.1" "504.7" "513.3" "" "" "" "" "" "" "" "" "" "" "402.8" "344.2" "393.0" "338.7" "363.8" "373.4" "353.8" "355.7" "504.7" "417.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7331213768411445402" "False" "High" "IsMasterProtein" "O95777" "U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3" "0.000" "False" "50.084" "61" "4" "16" "4" "96" "10.4" "4.48" "59.39" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51691" "ENSG00000128534" "LSM8" "hsa:51691; O95777" "mRNA Splicing - Major Pathway" "" "1" "0" "1.065" "0.979" "1.153" "0.959" "1.034" "1.013" "1.062" "1.032" "0.960" "363.7" "387.4" "355.9" "419.5" "348.7" "376.1" "368.4" "386.1" "375.2" "348.9" "" "" "" "" "" "" "" "" "" "" "292.1" "279.5" "282.7" "281.0" "241.2" "282.2" "257.9" "282.0" "375.2" "283.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8026992804565503724" "False" "High" "IsMasterProtein" "Q13257" "Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1" "0.000" "False" "50.066" "41" "8" "16" "8" "205" "23.5" "5.08" "51.33" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02301" "4085" "ENSG00000164109" "MAD2L1" "hsa:4085; Q13257; Q53F56; Q548X9; Q6IRW7; Q8IZX3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma" "13" "0" "0.990" "1.033" "0.927" "0.936" "0.999" "0.861" "0.918" "0.924" "0.952" "2182.5" "2160.4" "2254.3" "2023.7" "2042.6" "2180.1" "1878.7" "2002.7" "2017.6" "2078.1" "" "" "" "" "" "" "" "" "" "" "1753.0" "1558.9" "1790.6" "1355.9" "1412.7" "1635.7" "1315.4" "1462.6" "2017.6" "1690.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8295272483259113664" "False" "High" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "0.000" "False" "50.042" "67" "5" "15" "5" "95" "10.8" "6.52" "52.09" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "mRNA processing" "3" "0" "0.944" "0.964" "0.912" "0.914" "0.961" "0.915" "0.908" "0.849" "0.962" "757.2" "715.1" "729.7" "690.4" "692.1" "727.6" "692.9" "687.6" "642.7" "728.6" "" "" "" "" "" "" "" "" "" "" "608.2" "516.0" "579.7" "462.5" "478.7" "545.9" "485.1" "502.2" "642.7" "592.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591568921065242388" "False" "High" "IsMasterProtein" "Q8NB90" "ATPase family gene 2 protein homolog A OS=Homo sapiens OX=9606 GN=AFG2A PE=1 SV=3" "0.000" "False" "50.024" "13" "11" "16" "11" "893" "97.8" "5.66" "51.81" "11" "developmental processes;other biological processes" "cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf17862" "166378" "ENSG00000145375" "AFG2A" "C9JT97; hsa:166378; Q86XW1; Q8NB90; Q8NI20; Q8TDL7" "" "" "0" "0" "1.058" "1.030" "1.104" "1.182" "1.030" "1.129" "1.193" "1.080" "1.069" "815.4" "862.6" "840.0" "900.0" "964.2" "840.1" "920.8" "972.4" "880.8" "871.9" "" "" "" "" "" "" "" "" "" "" "654.9" "622.4" "667.2" "603.0" "666.8" "630.3" "644.7" "710.2" "880.8" "709.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719545438223687688" "False" "High" "IsMasterProtein" "Q9NWV8" "BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1" "0.000" "False" "50.021" "23" "5" "8" "5" "329" "36.5" "4.64" "33.55" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "" "29086" "ENSG00000105393" "BABAM1" "A8MQT0; B4DRY9; B4DVR1; hsa:29086; Q6FIA0; Q9NWV8; Q9P018" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "1.057" "1.039" "1.012" "1.098" "1.047" "1.039" "1.001" "1.038" "1.088" "297.2" "314.3" "308.8" "300.9" "326.2" "311.3" "308.7" "297.5" "308.7" "323.4" "" "" "" "" "" "" "" "" "" "" "238.7" "226.8" "245.3" "201.6" "225.6" "233.6" "216.1" "217.2" "308.7" "263.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993945663539599820" "False" "High" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "0.000" "False" "50.013" "50" "10" "21" "8" "200" "22.5" "8.38" "64.81" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; RAB geranylgeranylation" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "5" "0" "1.006" "1.049" "0.963" "1.036" "1.015" "1.053" "1.030" "0.999" "1.007" "1202.8" "1210.1" "1261.6" "1158.3" "1246.5" "1221.3" "1266.9" "1238.8" "1201.4" "1211.6" "" "" "" "" "" "" "" "" "" "" "966.1" "873.2" "1002.1" "776.1" "862.1" "916.3" "887.0" "904.7" "1201.4" "985.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350297391460659300" "False" "High" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "0.000" "False" "50.011" "47" "10" "15" "10" "223" "25.8" "9.54" "56.59" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.981" "1.082" "1.168" "1.148" "1.267" "1.312" "1.083" "1.154" "1.081" "812.5" "797.4" "879.0" "948.9" "932.5" "1029.7" "1066.2" "880.2" "938.0" "878.0" "" "" "" "" "" "" "" "" "" "" "652.6" "575.4" "698.3" "635.7" "644.9" "772.6" "746.5" "642.8" "938.0" "714.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8668239743978999828" "False" "High" "IsMasterProtein" "Q9NSI2" "Ribosome biogenesis protein SLX9 homolog OS=Homo sapiens OX=9606 GN=SLX9 PE=1 SV=2" "0.000" "False" "49.938" "33" "7" "13" "7" "230" "25.4" "11.08" "47.59" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf15341" "85395" "ENSG00000160256" "SLX9" "hsa:85395; Q9NSI2" "" "" "0" "0" "1.012" "1.065" "1.000" "1.014" "0.985" "1.004" "1.025" "0.989" "0.986" "465.0" "470.5" "495.1" "465.1" "471.3" "457.9" "467.0" "476.5" "459.8" "458.5" "" "" "" "" "" "" "" "" "" "" "373.5" "339.5" "393.3" "311.6" "326.0" "343.5" "326.9" "348.0" "459.8" "372.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6652011194005899795" "False" "High" "IsMasterProtein" "P29083" "General transcription factor IIE subunit 1 OS=Homo sapiens OX=9606 GN=GTF2E1 PE=1 SV=2" "0.000" "False" "49.870" "26" "8" "12" "8" "439" "49.4" "4.82" "37.38" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02002, Pf08271, Pf11521" "2960" "ENSG00000153767" "GTF2E1" "hsa:2960; P29083; Q16103" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "1.022" "0.951" "1.072" "1.041" "0.983" "0.975" "1.070" "0.981" "0.992" "568.3" "581.0" "540.3" "609.3" "591.8" "558.5" "554.3" "608.4" "557.7" "563.9" "" "" "" "" "" "" "" "" "" "" "456.5" "419.3" "429.2" "408.3" "409.3" "419.1" "388.1" "444.3" "557.7" "458.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1587907933929237870" "False" "High" "IsMasterProtein" "Q02548" "Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1" "0.000" "False" "49.845" "20" "5" "8" "5" "391" "42.1" "9.00" "35.22" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292, Pf12403" "5079" "ENSG00000196092" "PAX5" "A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; hsa:5079; O75933; Q02548; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732" "RUNX1 regulates transcription of genes involved in BCR signaling" "Prion disease pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; ID signaling pathway" "4" "0" "1.066" "0.977" "1.018" "1.082" "0.958" "0.899" "0.992" "0.917" "0.968" "722.2" "769.8" "705.6" "734.9" "781.3" "691.5" "649.0" "716.2" "662.5" "698.7" "" "" "" "" "" "" "" "" "" "" "580.0" "555.5" "560.5" "492.4" "540.4" "518.8" "454.4" "523.1" "662.5" "568.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8303204193391828869" "False" "High" "IsMasterProtein" "Q8WUI4" "Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2" "0.000" "False" "49.820" "14" "10" "12" "10" "952" "102.9" "7.58" "48.55" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "51564" "ENSG00000061273" "HDAC7" "B3KY08; B4DWI0; B4E0Q5; hsa:51564; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q8WUI4; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7" "SUMOylation of DNA damage response and repair proteins; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Gastrin signaling pathway" "13" "0" "1.028" "0.987" "1.028" "1.015" "0.986" "1.006" "1.022" "1.056" "1.046" "1364.0" "1402.7" "1346.3" "1402.0" "1385.1" "1345.4" "1372.5" "1393.6" "1440.6" "1426.6" "" "" "" "" "" "" "" "" "" "" "1095.6" "1012.1" "1069.4" "939.3" "957.9" "1009.4" "960.9" "1017.8" "1440.6" "1160.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-13985934146586024" "False" "High" "IsMasterProtein" "Q9HB65" "RNA polymerase II elongation factor ELL3 OS=Homo sapiens OX=9606 GN=ELL3 PE=1 SV=2" "0.000" "False" "49.819" "28" "8" "9" "8" "397" "45.3" "6.06" "35.80" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07303, Pf10390" "80237" "ENSG00000128886" "ELL3" "B3KQ66; B3KX08; hsa:80237; Q6I9Z7; Q9H634; Q9HB65" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.969" "0.939" "1.012" "0.967" "0.910" "0.972" "0.904" "0.852" "0.878" "204.4" "198.1" "192.0" "206.8" "197.6" "186.0" "198.7" "184.7" "174.2" "179.4" "" "" "" "" "" "" "" "" "" "" "164.2" "142.9" "152.6" "138.6" "136.7" "139.6" "139.1" "134.9" "174.2" "145.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264120083815806641" "False" "High" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "0.000" "False" "49.776" "58" "7" "23" "7" "125" "14.3" "6.04" "60.81" "7" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "1.119" "1.127" "1.147" "1.139" "1.106" "1.129" "1.189" "1.101" "1.121" "2027.0" "2268.9" "2284.1" "2324.4" "2308.4" "2242.1" "2288.2" "2410.1" "2232.4" "2271.4" "" "" "" "" "" "" "" "" "" "" "1628.0" "1637.2" "1814.4" "1557.4" "1596.5" "1682.2" "1602.1" "1760.1" "2232.4" "1847.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4480157126328656163" "False" "High" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "0.000" "False" "49.774" "33" "11" "27" "11" "253" "29.8" "9.06" "75.16" "11" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.013" "1.036" "0.987" "0.998" "1.036" "1.055" "1.073" "1.017" "0.998" "3433.5" "3479.4" "3557.1" "3390.5" "3427.4" "3556.6" "3623.9" "3682.9" "3490.7" "3426.6" "" "" "" "" "" "" "" "" "" "" "2757.8" "2510.7" "2825.5" "2271.6" "2370.4" "2668.4" "2537.3" "2689.6" "3490.7" "2786.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "647250025127974157" "False" "High" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "0.000" "False" "49.740" "56" "6" "12" "6" "111" "12.0" "9.83" "54.97" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "Termination of translesion DNA synthesis" "" "1" "0" "1.064" "1.068" "1.102" "1.143" "1.073" "1.944" "2.067" "2.129" "1.312" "672.9" "715.8" "719.0" "741.2" "769.2" "722.2" "1308.0" "1390.7" "1432.6" "883.1" "" "" "" "" "" "" "" "" "" "" "540.5" "516.5" "571.1" "496.6" "532.0" "541.8" "915.8" "1015.6" "1432.6" "718.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5976996630127458514" "False" "High" "IsMasterProtein" "O75815" "Breast cancer anti-estrogen resistance protein 3 OS=Homo sapiens OX=9606 GN=BCAR3 PE=1 SV=1" "0.000" "False" "49.687" "15" "9" "13" "9" "825" "92.5" "7.96" "40.82" "9" "developmental processes;signal transduction;other biological processes" "other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00617" "8412" "ENSG00000137936" "BCAR3" "D3DT43; hsa:8412; O75815; Q5TEW3; Q6UW40; Q9BR50" "" "" "0" "0" "1.089" "1.060" "1.149" "1.075" "1.013" "1.097" "1.133" "1.113" "1.096" "461.5" "502.8" "489.3" "530.1" "496.2" "467.4" "506.3" "522.8" "513.7" "506.0" "" "" "" "" "" "" "" "" "" "" "370.7" "362.8" "388.6" "355.2" "343.2" "350.7" "354.5" "381.8" "513.7" "411.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7717168989126712836" "False" "High" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "0.000" "False" "49.664" "14" "9" "13" "9" "677" "76.2" "7.03" "44.22" "9" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "DNA repair pathways, full network" "5" "0" "0.995" "0.976" "1.020" "1.073" "1.007" "1.019" "1.027" "1.015" "1.041" "1395.9" "1388.9" "1363.0" "1424.0" "1497.9" "1405.2" "1422.3" "1434.1" "1416.2" "1453.7" "" "" "" "" "" "" "" "" "" "" "1121.2" "1002.2" "1082.6" "954.1" "1036.0" "1054.3" "995.8" "1047.3" "1416.2" "1182.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9216601272429108085" "False" "High" "IsMasterProtein" "Q96GX9" "Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1" "0.000" "False" "49.638" "46" "9" "17" "9" "242" "27.1" "7.12" "50.19" "9" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00596" "51074" "ENSG00000149089" "APIP" "A8K9D3; hsa:51074; Q6PJX6; Q8WVU2; Q96GX9; Q96HK2; Q9Y318" "Regulation of the apoptosome activity; Methionine salvage pathway" "Methionine de novo and salvage pathway" "4" "0" "1.059" "1.010" "1.007" "0.925" "1.058" "0.904" "0.889" "0.920" "1.008" "1534.4" "1624.6" "1549.0" "1544.7" "1419.2" "1623.2" "1386.5" "1363.4" "1412.4" "1546.3" "" "" "" "" "" "" "" "" "" "" "1232.4" "1172.2" "1230.4" "1035.0" "981.6" "1217.8" "970.8" "995.7" "1412.4" "1257.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949132700508493695" "False" "High" "IsMasterProtein" "Q8WW59" "SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=3" "0.000" "False" "49.619" "44" "8" "12" "8" "207" "23.1" "6.93" "40.11" "8" "" "nucleus" "" "Pf00622" "283377" "ENSG00000176422" "SPRYD4" "A8K7A5; hsa:283377; Q8WW59" "" "" "0" "0" "1.020" "1.034" "1.032" "1.058" "1.014" "1.036" "0.971" "1.006" "0.958" "836.6" "853.3" "864.9" "863.5" "885.1" "847.9" "866.6" "812.3" "841.6" "801.3" "" "" "" "" "" "" "" "" "" "" "671.9" "615.7" "687.0" "578.5" "612.2" "636.1" "606.8" "593.3" "841.6" "651.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8633785530779633839" "False" "High" "IsMasterProtein" "P49354" "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1" "0.000" "False" "49.599" "28" "10" "16" "10" "379" "44.4" "5.08" "48.22" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01239" "2339" "ENSG00000168522" "FNTA" "A6NJW0; hsa:2339; P49354; Q53XJ9; Q9UDC1" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing; Apoptotic cleavage of cellular proteins" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "9" "0" "1.021" "1.059" "1.057" "1.063" "1.091" "0.979" "1.046" "1.019" "1.046" "958.0" "978.1" "1014.9" "1012.9" "1018.2" "1044.8" "938.2" "1002.0" "976.3" "1002.1" "" "" "" "" "" "" "" "" "" "" "769.5" "705.8" "806.2" "678.6" "704.2" "783.9" "656.9" "731.8" "976.3" "815.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5422158606125759469" "False" "High" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "0.000" "False" "49.595" "27" "7" "16" "7" "306" "32.7" "5.06" "61.34" "7" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing" "mRNA processing" "7" "0" "0.954" "0.981" "0.956" "1.002" "0.925" "0.956" "0.935" "0.937" "0.952" "2268.0" "2163.3" "2224.5" "2167.2" "2272.1" "2097.2" "2167.6" "2120.9" "2124.0" "2158.8" "" "" "" "" "" "" "" "" "" "" "1821.6" "1561.0" "1767.0" "1452.0" "1571.4" "1573.5" "1517.6" "1548.9" "2124.0" "1755.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892989875718200247" "False" "High" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "0.000" "False" "49.592" "38" "10" "22" "10" "239" "27.4" "5.73" "46.65" "10" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Ub-specific processing proteases; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Interleukin-1 signaling; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Somitogenesis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity" "Proteasome degradation" "61" "0" "0.964" "1.001" "0.957" "0.965" "1.030" "1.009" "0.982" "1.071" "0.972" "1867.9" "1801.4" "1870.1" "1786.9" "1803.1" "1924.5" "1884.0" "1835.0" "2001.0" "1815.5" "" "" "" "" "" "" "" "" "" "" "1500.3" "1299.8" "1485.5" "1197.2" "1247.0" "1443.9" "1319.1" "1340.1" "2001.0" "1476.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778501702482241288" "False" "High" "IsMasterProtein" "P41182" "B-cell lymphoma 6 protein OS=Homo sapiens OX=9606 GN=BCL6 PE=1 SV=1" "0.000" "False" "49.544" "14" "9" "11" "9" "706" "78.8" "7.94" "44.15" "9" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "604" "ENSG00000113916" "BCL6" "A7E241; B8PSA7; D3DNV5; hsa:604; P41182" "Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; FOXO-mediated transcription of cell death genes" "B cell receptor signaling pathway; Vitamin D receptor pathway; MECP2 and associated Rett syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Extrafollicular and follicular B cell activation by SARS-CoV-2; DNA damage response (only ATM dependent)" "9" "0" "1.032" "0.987" "0.978" "0.967" "1.001" "0.834" "0.888" "0.810" "0.941" "782.9" "807.8" "772.4" "765.4" "756.8" "783.6" "652.6" "695.3" "633.8" "736.3" "" "" "" "" "" "" "" "" "" "" "628.8" "582.9" "613.6" "512.8" "523.4" "587.9" "456.9" "507.8" "633.8" "598.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4154359228263867930" "False" "High" "IsMasterProtein" "P46781" "Small ribosomal subunit protein uS4 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "0.000" "False" "49.543" "51" "12" "17" "12" "194" "22.6" "10.65" "52.17" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "1.028" "1.200" "1.186" "1.162" "1.100" "1.202" "1.254" "1.185" "1.135" "1303.1" "1339.6" "1564.0" "1545.4" "1514.4" "1433.6" "1566.1" "1634.5" "1544.0" "1479.1" "" "" "" "" "" "" "" "" "" "" "1046.6" "966.6" "1242.3" "1035.4" "1047.4" "1075.6" "1096.5" "1193.7" "1544.0" "1202.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585419871706527859" "False" "High" "IsMasterProtein" "Q8TDY2" "RB1-inducible coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=RB1CC1 PE=1 SV=3" "0.000" "False" "49.520" "8" "12" "12" "12" "1594" "183.0" "5.41" "37.96" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10377" "9821" "ENSG00000023287" "RB1CC1" "hsa:9821; Q86YR4; Q8TDY2; Q8WVU9; Q92601" "Macroautophagy" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "11" "0" "1.061" "0.984" "1.043" "1.014" "0.982" "1.042" "1.002" "1.057" "1.046" "859.4" "912.2" "845.5" "896.5" "871.0" "844.3" "895.8" "861.3" "908.4" "898.9" "" "" "" "" "" "" "" "" "" "" "690.3" "658.2" "671.6" "600.6" "602.4" "633.5" "627.2" "629.0" "908.4" "731.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7101780835120275737" "False" "High" "IsMasterProtein" "Q9Y3Q8" "TSC22 domain family protein 4 OS=Homo sapiens OX=9606 GN=TSC22D4 PE=1 SV=2" "0.000" "False" "49.485" "26" "8" "14" "6" "395" "41.0" "7.21" "46.56" "8" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf01166" "81628" "ENSG00000166925" "TSC22D4" "A4D2C3; A8MWR6; D6W5V9; hsa:81628; Q9Y3Q8" "" "" "0" "2" "1.107" "1.045" "0.992" "0.953" "1.025" "0.983" "0.970" "1.059" "0.983" "849.7" "940.4" "888.3" "843.0" "809.6" "870.7" "835.1" "824.4" "900.0" "835.5" "" "" "" "" "" "" "" "" "" "" "682.5" "678.5" "705.6" "564.8" "559.9" "653.3" "584.7" "602.1" "900.0" "679.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802670806529502835" "False" "High" "IsMasterProtein" "Q6NYC8" "Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1" "0.000" "False" "49.399" "16" "9" "11" "9" "613" "67.9" "5.40" "41.30" "9" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf13914, Pf13916" "170954" "ENSG00000146112; ENSG00000206485; ENSG00000225060; ENSG00000229998; ENSG00000230341; ENSG00000234000" "PPP1R18" "A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; hsa:170954; Q68CK8; Q6NYC8; Q6ZTV1; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9" "" "TYROBP causal network in microglia" "1" "0" "1.034" "0.979" "1.048" "1.149" "1.070" "1.223" "1.052" "1.096" "1.070" "670.2" "693.2" "656.4" "702.4" "770.2" "717.3" "819.5" "705.3" "734.5" "717.4" "" "" "" "" "" "" "" "" "" "" "538.3" "500.2" "521.4" "470.6" "532.7" "538.2" "573.8" "515.1" "734.5" "583.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2662699924812854810" "False" "High" "IsMasterProtein" "Q9P219" "Protein Daple OS=Homo sapiens OX=9606 GN=CCDC88C PE=1 SV=3" "0.000" "False" "49.397" "5" "10" "12" "10" "2028" "228.1" "6.23" "38.65" "10" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "440193" "ENSG00000015133" "CCDC88C" "hsa:440193; Q69YK1; Q7L1M2; Q86SX7; Q8IYG8; Q9P219" "Negative regulation of TCF-dependent signaling by DVL-interacting proteins" "Ectoderm differentiation; Ectoderm differentiation" "3" "0" "1.047" "0.970" "1.106" "1.063" "0.987" "1.130" "1.079" "1.048" "1.025" "163.2" "170.8" "158.3" "180.5" "173.5" "161.1" "184.5" "176.1" "170.9" "167.2" "" "" "" "" "" "" "" "" "" "" "131.1" "123.3" "125.7" "120.9" "120.0" "120.9" "129.1" "128.6" "170.9" "136.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8999845406277562527" "False" "High" "IsMasterProtein" "Q9H089" "Large subunit GTPase 1 homolog OS=Homo sapiens OX=9606 GN=LSG1 PE=1 SV=2" "0.000" "False" "49.394" "18" "12" "15" "12" "658" "75.2" "6.38" "50.46" "12" "transport" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01926" "55341" "ENSG00000041802" "LSG1" "A0JLT4; A0PJK3; A6NI18; hsa:55341; Q7L9H8; Q9H089; Q9NUK8" "" "" "0" "0" "1.045" "0.939" "1.083" "1.097" "1.073" "1.127" "1.113" "1.112" "1.039" "967.0" "1010.7" "908.2" "1047.5" "1060.7" "1037.5" "1089.7" "1076.4" "1074.8" "1004.6" "" "" "" "" "" "" "" "" "" "" "776.7" "729.3" "721.4" "701.8" "733.6" "778.4" "763.0" "786.1" "1074.8" "817.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4204109305997435954" "False" "High" "IsMasterProtein" "Q07960" "Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1" "0.000" "False" "49.367" "34" "12" "15" "12" "439" "50.4" "6.29" "49.53" "12" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf13716" "392" "ENSG00000175220" "ARHGAP1" "D3DQQ6; hsa:392; Q07960" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "" "13" "0" "1.003" "1.018" "1.011" "0.928" "0.907" "0.891" "1.015" "0.997" "0.956" "1249.5" "1253.7" "1271.9" "1263.5" "1159.0" "1133.0" "1112.8" "1267.9" "1246.1" "1194.5" "" "" "" "" "" "" "" "" "" "" "1003.6" "904.6" "1010.3" "846.5" "801.5" "850.1" "779.1" "925.9" "1246.1" "971.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6594093010420554285" "False" "High" "IsMasterProtein" "Q9NWZ3" "Interleukin-1 receptor-associated kinase 4 OS=Homo sapiens OX=9606 GN=IRAK4 PE=1 SV=1" "0.000" "False" "49.289" "23" "11" "15" "11" "460" "51.5" "5.41" "44.41" "11" "other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "51135" "ENSG00000198001" "IRAK4" "hsa:51135; Q69FE1; Q8TDF7; Q9NWZ3; Q9Y589" "Interleukin-1 signaling; PIP3 activates AKT signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; IRAK4 deficiency (TLR2/4); PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Toll-like receptor signaling pathway" "23" "0" "1.017" "0.971" "0.948" "0.968" "0.945" "0.959" "1.006" "1.011" "0.969" "1944.4" "1978.4" "1887.4" "1844.0" "1881.8" "1838.4" "1865.6" "1956.4" "1965.9" "1883.6" "" "" "" "" "" "" "" "" "" "" "1561.7" "1427.6" "1499.2" "1235.5" "1301.5" "1379.3" "1306.2" "1428.7" "1965.9" "1531.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271968905262141895" "False" "High" "IsMasterProtein" "Q4VC31" "Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1" "0.000" "False" "49.273" "51" "6" "16" "6" "144" "16.6" "7.81" "52.45" "6" "" "mitochondrion" "" "Pf09774" "131076" "ENSG00000160124" "MIX23" "hsa:131076; Q32LY6; Q4VC31" "" "" "0" "0" "1.048" "1.012" "1.037" "0.981" "0.947" "1.025" "0.959" "0.938" "0.976" "948.4" "994.1" "959.6" "983.1" "930.6" "897.8" "972.2" "910.0" "889.4" "925.3" "" "" "" "" "" "" "" "" "" "" "761.8" "717.3" "762.3" "658.7" "643.6" "673.6" "680.7" "664.6" "889.4" "752.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1901322686263979467" "False" "High" "IsMasterProtein" "Q32P44" "Echinoderm microtubule-associated protein-like 3 OS=Homo sapiens OX=9606 GN=EML3 PE=1 SV=1" "0.000" "False" "49.202" "13" "9" "9" "9" "896" "95.1" "7.12" "32.57" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "256364" "ENSG00000149499" "EML3" "hsa:256364; Q32P44; Q6ZQW7; Q8NA55" "" "" "0" "0" "1.027" "0.973" "1.013" "1.058" "0.986" "1.031" "1.017" "1.059" "1.047" "780.2" "801.6" "759.4" "790.0" "825.8" "769.2" "804.7" "793.3" "826.3" "816.6" "" "" "" "" "" "" "" "" "" "" "626.6" "578.4" "603.2" "529.3" "571.1" "577.1" "563.4" "579.4" "826.3" "664.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3133917976218081073" "False" "High" "IsMasterProtein" "Q9Y3D8" "Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1" "0.000" "False" "49.185" "52" "6" "11" "6" "172" "20.0" "4.58" "45.27" "6" "other metabolic processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf13238" "102157402" "ENSG00000085231; ENSG00000279247" "AK6" "A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "0.974" "0.984" "1.003" "0.983" "0.950" "0.955" "0.988" "1.023" "0.956" "831.5" "810.1" "818.4" "833.7" "817.3" "789.9" "794.3" "821.5" "850.3" "795.1" "" "" "" "" "" "" "" "" "" "" "667.8" "584.5" "650.1" "558.6" "565.3" "592.7" "556.1" "599.9" "850.3" "646.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7202922108567294127" "False" "High" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "0.000" "False" "49.173" "18" "9" "14" "9" "508" "55.0" "7.06" "46.77" "9" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "EGF/EGFR signaling pathway" "8" "0" "0.960" "0.981" "0.937" "0.956" "0.979" "0.952" "0.936" "0.979" "0.973" "1480.1" "1421.4" "1451.9" "1386.5" "1414.9" "1448.8" "1409.1" "1385.5" "1449.1" "1440.0" "" "" "" "" "" "" "" "" "" "" "1188.8" "1025.6" "1153.3" "928.9" "978.6" "1087.0" "986.6" "1011.8" "1449.1" "1171.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397920079809031089" "False" "High" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "0.000" "False" "49.074" "17" "11" "15" "11" "666" "73.1" "5.59" "45.24" "11" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "TYROBP causal network in microglia" "11" "0" "1.026" "1.030" "1.037" "1.000" "1.049" "0.923" "0.911" "0.966" "0.989" "1004.0" "1030.4" "1034.6" "1041.4" "1003.6" "1053.3" "926.8" "915.0" "970.4" "993.0" "" "" "" "" "" "" "" "" "" "" "806.4" "743.5" "821.8" "697.7" "694.1" "790.3" "648.9" "668.2" "970.4" "807.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8568464795180105445" "False" "High" "IsMasterProtein" "Q9Y385" "Ubiquitin-conjugating enzyme E2 J1 OS=Homo sapiens OX=9606 GN=UBE2J1 PE=1 SV=2" "0.000" "False" "49.038" "20" "5" "9" "5" "318" "35.2" "6.74" "40.96" "5" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00179" "51465" "ENSG00000198833" "UBE2J1" "A8K3F9; hsa:51465; Q53F25; Q5W0N4; Q9BZ32; Q9NQL3; Q9NY66; Q9P011; Q9P0S0; Q9UF10; Q9Y385" "Antigen processing: Ubiquitination & Proteasome degradation" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "3" "0" "0.975" "0.987" "1.020" "0.923" "1.000" "0.955" "1.034" "1.087" "1.018" "895.0" "872.9" "883.2" "912.6" "825.9" "895.2" "854.6" "925.3" "972.4" "911.4" "" "" "" "" "" "" "" "" "" "" "718.8" "629.9" "701.5" "611.5" "571.2" "671.6" "598.3" "675.7" "972.4" "741.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2487901490658103836" "False" "High" "IsMasterProtein" "O75995" "SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2" "0.000" "False" "48.960" "25" "6" "8" "6" "380" "41.6" "5.27" "37.67" "6" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf00536, Pf07653, Pf12485" "54440" "ENSG00000122122" "SASH3" "A6NCH1; A8K7K8; hsa:54440; O75995; Q5JZ38" "" "" "0" "0" "1.071" "1.037" "1.046" "1.034" "1.166" "0.981" "0.990" "1.115" "1.110" "509.2" "545.5" "528.3" "532.4" "526.7" "593.6" "499.4" "504.3" "567.8" "565.1" "" "" "" "" "" "" "" "" "" "" "409.0" "393.6" "419.6" "356.7" "364.3" "445.4" "349.7" "368.3" "567.8" "459.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8965718931841673636" "False" "High" "IsMasterProtein" "Q9Y496" "Kinesin-like protein KIF3A OS=Homo sapiens OX=9606 GN=KIF3A PE=1 SV=4" "0.000" "False" "48.958" "18" "12" "20" "10" "699" "80.0" "6.54" "46.92" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "11127" "ENSG00000131437" "KIF3A" "A8MSW9; hsa:11127; Q59EN1; Q86XE9; Q9Y496; Q9Y6V4" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO" "Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling" "11" "1" "0.980" "0.959" "0.991" "1.002" "0.924" "0.933" "1.058" "0.955" "0.984" "651.8" "639.1" "624.9" "645.7" "653.4" "602.6" "608.2" "689.7" "622.3" "641.5" "" "" "" "" "" "" "" "" "" "" "523.6" "461.2" "496.4" "432.6" "451.9" "452.1" "425.8" "503.7" "622.3" "521.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973813700341614243" "False" "High" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "0.000" "False" "48.907" "15" "9" "12" "6" "655" "74.3" "6.16" "41.07" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "Maturation of nucleoprotein; Replacement of protamines by nucleosomes in the male pronucleus" "VEGFA-VEGFR2 signaling; mRNA processing" "4" "2" "1.041" "1.038" "1.137" "1.082" "1.011" "1.101" "1.057" "1.097" "1.037" "806.9" "839.9" "837.8" "917.8" "872.9" "816.1" "888.6" "853.1" "885.3" "836.9" "" "" "" "" "" "" "" "" "" "" "648.1" "606.1" "665.5" "614.9" "603.7" "612.3" "622.1" "623.0" "885.3" "680.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5690407567518484702" "False" "High" "IsMasterProtein" "Q9HCS7" "Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2" "0.000" "False" "48.892" "15" "12" "13" "12" "855" "99.9" "6.23" "46.31" "12" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf13181" "56949" "ENSG00000076924" "XAB2" "hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "Rett syndrome; Nucleotide excision repair in xeroderma pigmentosum" "7" "0" "1.057" "1.074" "1.073" "1.035" "1.012" "1.028" "1.050" "1.049" "1.020" "786.1" "830.9" "844.6" "843.5" "813.7" "795.4" "808.1" "825.1" "824.8" "801.5" "" "" "" "" "" "" "" "" "" "" "631.4" "599.5" "670.9" "565.1" "562.8" "596.8" "565.8" "602.6" "824.8" "651.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4118942694403519746" "False" "High" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "0.000" "False" "48.869" "19" "10" "16" "10" "652" "70.7" "7.90" "45.24" "10" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RND3 GTPase cycle" "" "4" "0" "1.066" "1.039" "1.016" "1.033" "1.022" "0.984" "1.023" "0.983" "1.021" "1348.7" "1437.6" "1401.5" "1370.4" "1393.7" "1378.7" "1326.8" "1379.6" "1325.9" "1377.3" "" "" "" "" "" "" "" "" "" "" "1083.2" "1037.3" "1113.2" "918.1" "963.9" "1034.4" "929.0" "1007.5" "1325.9" "1120.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1860975273197737865" "False" "High" "IsMasterProtein" "P19784" "Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1" "0.000" "False" "48.869" "34" "10" "13" "9" "350" "41.2" "8.56" "43.51" "10" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1459" "ENSG00000070770" "CSNK2A2" "hsa:1459; P19784" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "21" "0" "1.015" "1.106" "1.035" "0.939" "1.057" "1.041" "1.019" "1.038" "1.049" "660.5" "670.7" "730.4" "683.9" "620.0" "698.1" "687.4" "673.0" "685.7" "692.6" "" "" "" "" "" "" "" "" "" "" "530.5" "483.9" "580.2" "458.2" "428.8" "523.8" "481.3" "491.5" "685.7" "563.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101448346661809879" "False" "High" "IsMasterProtein" "Q15819" "Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4" "0.000" "False" "48.856" "58" "8" "28" "3" "145" "16.4" "8.09" "75.07" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00179" "7336" "ENSG00000169139" "UBE2V2" "hsa:7336; Q15819" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER" "" "7" "0" "1.064" "0.951" "1.011" "0.955" "0.939" "1.048" "0.980" "1.025" "1.039" "591.7" "629.5" "562.9" "598.3" "565.3" "555.6" "620.1" "579.7" "606.7" "614.9" "" "" "" "" "" "" "" "" "" "" "475.3" "454.2" "447.1" "400.8" "391.0" "416.9" "434.2" "423.4" "606.7" "500.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415542887713691593" "False" "High" "IsMasterProtein" "Q01469" "Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3" "0.000" "False" "48.838" "69" "8" "39" "8" "135" "15.2" "7.01" "116.48" "8" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00061" "2171" "ENSG00000164687" "FABP5" "B2R4K0; hsa:2171; Q01469" "Neutrophil degranulation; Triglyceride catabolism; Signaling by Retinoic Acid" "PPAR signaling pathway; Fatty acid transporters" "5" "0" "1.066" "1.013" "1.052" "1.048" "1.008" "1.073" "1.067" "1.002" "1.017" "2462.2" "2624.6" "2495.3" "2589.5" "2580.5" "2481.2" "2642.3" "2627.8" "2466.3" "2504.9" "" "" "" "" "" "" "" "" "" "" "1977.6" "1893.8" "1982.1" "1735.0" "1784.7" "1861.6" "1850.0" "1919.1" "2466.3" "2037.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302134313779443403" "False" "High" "IsMasterProtein" "Q96ER3" "Protein SAAL1 OS=Homo sapiens OX=9606 GN=SAAL1 PE=1 SV=2" "0.000" "False" "48.835" "24" "9" "12" "9" "474" "53.5" "4.50" "44.65" "9" "other biological processes" "nucleus" "" "" "113174" "ENSG00000166788" "SAAL1" "A6NH05; hsa:113174; Q96ER3" "" "" "0" "0" "0.971" "0.966" "0.977" "0.942" "0.974" "0.943" "1.007" "0.947" "0.970" "1095.6" "1063.4" "1057.9" "1070.5" "1032.5" "1066.9" "1032.9" "1103.0" "1037.4" "1062.9" "" "" "" "" "" "" "" "" "" "" "879.9" "767.4" "840.3" "717.2" "714.1" "800.5" "723.2" "805.6" "1037.4" "864.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7599147423310777868" "False" "High" "IsMasterProtein" "P55199" "RNA polymerase II elongation factor ELL OS=Homo sapiens OX=9606 GN=ELL PE=1 SV=1" "0.000" "False" "48.811" "17" "8" "9" "8" "621" "68.2" "9.33" "32.92" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07303, Pf10390" "8178" "ENSG00000105656" "ELL" "hsa:8178; P55199" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Transcription-Coupled Nucleotide Excision Repair (TC-NER)" "Interactome of polycomb repressive complex 2 (PRC2)" "14" "0" "0.993" "0.973" "0.944" "0.919" "0.911" "0.917" "0.969" "0.985" "0.969" "284.6" "282.7" "276.9" "268.7" "261.5" "259.1" "261.0" "275.9" "280.4" "275.8" "" "" "" "" "" "" "" "" "" "" "228.6" "204.0" "219.9" "180.0" "180.8" "194.4" "182.8" "201.5" "280.4" "224.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060406091306601688" "False" "High" "IsMasterProtein" "Q8N806" "Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2" "0.000" "False" "48.789" "26" "10" "12" "10" "425" "48.0" "4.81" "32.78" "10" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf02207" "55148" "ENSG00000012963; ENSG00000278787" "UBR7" "Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6" "" "" "0" "0" "1.019" "1.035" "1.065" "0.950" "1.028" "1.105" "1.016" "1.124" "1.009" "651.1" "663.6" "673.6" "693.2" "618.8" "669.4" "719.2" "661.6" "732.0" "656.7" "" "" "" "" "" "" "" "" "" "" "522.9" "478.8" "535.1" "464.5" "428.0" "502.3" "503.5" "483.1" "732.0" "534.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8283014115765105916" "False" "High" "IsMasterProtein" "Q9UP83" "Conserved oligomeric Golgi complex subunit 5 OS=Homo sapiens OX=9606 GN=COG5 PE=1 SV=4" "0.000" "False" "48.774" "14" "11" "14" "11" "860" "94.8" "6.60" "45.28" "11" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf10392, Pf20649" "10466" "ENSG00000164597" "COG5" "A4D0R6; A4D0R7; hsa:10466; O14555; O95008; Q6NUL5; Q9UP83" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport" "" "3" "0" "0.972" "0.977" "0.942" "0.935" "0.989" "0.847" "0.926" "0.951" "0.951" "892.2" "867.3" "871.4" "840.5" "834.0" "882.5" "755.6" "825.9" "848.9" "848.9" "" "" "" "" "" "" "" "" "" "" "716.6" "625.9" "692.2" "563.1" "576.8" "662.1" "529.0" "603.2" "848.9" "690.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4307491490075501206" "False" "High" "IsMasterProtein" "P32322" "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" "0.000" "False" "48.753" "27" "6" "8" "5" "319" "33.3" "7.61" "32.25" "6" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "5831" "ENSG00000183010" "PYCR1" "A6NFM2; B4DMU0; hsa:5831; P32322; Q6FHI4; Q96DI6; Q9HBQ4" "Glutamate and glutamine metabolism" "Amino acid metabolism; Metabolic reprogramming in colon cancer" "3" "0" "1.081" "0.953" "1.114" "1.088" "0.929" "1.000" "1.162" "1.021" "1.050" "418.2" "452.0" "398.5" "465.7" "455.1" "388.6" "418.3" "485.9" "427.1" "439.2" "" "" "" "" "" "" "" "" "" "" "335.9" "326.1" "316.5" "312.0" "314.7" "291.6" "292.8" "354.9" "427.1" "357.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5798091253452066801" "False" "High" "IsMasterProtein" "Cont_Q86YZ3" "Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2" "0.000" "True" "48.722" "8" "6" "7" "6" "2850" "282.2" "10.04" "27.68" "6" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01023" "388697" "ENSG00000197915" "HRNR" "hsa:388697; Q5DT20; Q5U1F4; Q86YZ3" "Neutrophil degranulation" "" "1" "0" "0.835" "0.255" "0.909" "0.472" "0.748" "1.972" "0.756" "0.603" "0.654" "217.2" "181.3" "55.4" "197.5" "102.6" "162.5" "428.2" "164.1" "130.9" "142.0" "" "" "" "" "" "" "" "" "" "" "174.4" "130.8" "44.0" "132.3" "71.0" "121.9" "299.8" "119.9" "130.9" "115.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145009283245857027" "False" "High" "IsMasterProtein" "P62487" "DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1" "0.000" "False" "48.709" "30" "4" "13" "4" "172" "19.3" "5.54" "47.78" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00575, Pf03876" "5436" "ENSG00000168002" "POLR2G" "B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "0.958" "0.990" "0.975" "0.945" "0.962" "0.926" "0.976" "0.948" "0.988" "1239.7" "1187.4" "1227.4" "1208.4" "1171.2" "1192.5" "1148.0" "1209.4" "1174.7" "1225.3" "" "" "" "" "" "" "" "" "" "" "995.7" "856.8" "975.0" "809.6" "810.0" "894.7" "803.8" "883.2" "1174.7" "996.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6442873191784740439" "False" "High" "IsMasterProtein" "Q9BXW7" "Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1" "0.000" "False" "48.705" "30" "9" "16" "9" "423" "46.3" "8.13" "46.00" "9" "other metabolic processes" "mitochondrion" "" "Pf13344" "27440" "ENSG00000069998" "HDHD5" "B2RCK5; Q9BXW7; Q9BXW8; Q9NWA8; Q9NX41" "" "" "0" "0" "0.974" "0.984" "1.059" "0.985" "1.016" "0.932" "0.998" "0.948" "1.020" "703.7" "685.7" "692.5" "745.3" "693.0" "715.1" "655.6" "702.1" "666.8" "718.0" "" "" "" "" "" "" "" "" "" "" "565.2" "494.8" "550.1" "499.4" "479.3" "536.6" "459.0" "512.8" "666.8" "583.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991107467839093977" "False" "High" "IsMasterProtein" "Q99747" "Gamma-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPG PE=1 SV=1" "0.000" "False" "48.680" "29" "9" "16" "9" "312" "34.7" "5.41" "47.34" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf14938" "8774" "ENSG00000134265" "NAPG" "B4DFC9; hsa:8774; Q99747; Q9BUV1" "COPII-mediated vesicle transport; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "5" "0" "0.994" "0.940" "0.995" "0.953" "0.965" "1.058" "0.971" "0.992" "0.978" "1376.1" "1368.2" "1294.0" "1369.5" "1311.5" "1328.0" "1455.4" "1336.3" "1365.6" "1345.5" "" "" "" "" "" "" "" "" "" "" "1105.2" "987.2" "1027.9" "917.6" "907.1" "996.4" "1019.0" "975.9" "1365.6" "1094.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3239366280692976916" "False" "High" "IsMasterProtein" "O14920" "Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Homo sapiens OX=9606 GN=IKBKB PE=1 SV=1" "0.000" "False" "48.678" "16" "11" "13" "10" "756" "86.5" "5.78" "38.43" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "3551" "ENSG00000104365" "IKBKB" "B4DZ30; B4E0U4; hsa:3551; O14920; O75327" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Polycystic kidney disease pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "91" "1" "0.992" "1.027" "0.973" "0.997" "0.991" "0.999" "0.991" "0.895" "0.994" "942.8" "934.9" "968.4" "917.1" "940.3" "933.9" "941.6" "934.6" "843.5" "936.9" "" "" "" "" "" "" "" "" "" "" "757.2" "674.6" "769.3" "614.4" "650.3" "700.7" "659.3" "682.6" "843.5" "761.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846658872779087383" "False" "High" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "0.000" "False" "48.658" "31" "9" "14" "9" "334" "36.6" "8.27" "44.79" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RMTs methylate histone arginines; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis" "Pleural mesothelioma; Kleefstra syndrome" "10" "0" "1.050" "1.109" "0.982" "1.030" "1.058" "1.010" "1.075" "1.046" "1.082" "637.9" "670.0" "707.7" "626.6" "657.3" "674.7" "644.4" "685.7" "667.4" "690.4" "" "" "" "" "" "" "" "" "" "" "512.4" "483.5" "562.2" "419.8" "454.6" "506.2" "451.2" "500.7" "667.4" "561.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533705047032389806" "False" "High" "IsMasterProtein" "P62241" "Small ribosomal subunit protein eS8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "0.000" "False" "48.611" "45" "8" "16" "8" "208" "24.2" "10.32" "49.97" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.007" "0.990" "1.068" "1.057" "0.993" "1.064" "1.067" "1.023" "1.021" "557.4" "561.5" "552.0" "595.3" "588.9" "553.5" "592.8" "594.6" "570.2" "568.9" "" "" "" "" "" "" "" "" "" "" "447.7" "405.1" "438.5" "398.8" "407.3" "415.3" "415.0" "434.3" "570.2" "462.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7451398436155471702" "False" "High" "IsMasterProtein" "Q9BRZ2" "E3 ubiquitin-protein ligase TRIM56 OS=Homo sapiens OX=9606 GN=TRIM56 PE=1 SV=3" "0.000" "False" "48.609" "13" "8" "10" "7" "755" "81.4" "7.74" "31.82" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00643, Pf13445" "81844" "ENSG00000169871" "TRIM56" "hsa:81844; Q6PJS5; Q86VT6; Q8N2H8; Q8NAC0; Q9BRZ2; Q9H031" "Regulation of innate immune responses to cytosolic DNA" "" "1" "1" "1.111" "1.012" "1.114" "1.121" "0.993" "1.174" "1.125" "1.144" "1.104" "431.7" "479.6" "437.0" "481.1" "484.1" "428.5" "506.7" "485.8" "493.7" "476.8" "" "" "" "" "" "" "" "" "" "" "346.7" "346.0" "347.1" "322.3" "334.8" "321.5" "354.7" "354.8" "493.7" "387.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8789508812130398643" "False" "High" "IsMasterProtein" "Q9BTE7" "DCN1-like protein 5 OS=Homo sapiens OX=9606 GN=DCUN1D5 PE=1 SV=1" "0.000" "False" "48.606" "35" "8" "13" "8" "237" "27.5" "5.58" "42.28" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03556" "84259" "ENSG00000137692" "DCUN1D5" "hsa:84259; Q3ZTT2; Q9BTE7" "Neddylation" "" "1" "0" "1.015" "0.999" "0.980" "0.970" "0.984" "0.904" "0.987" "0.913" "0.983" "1363.4" "1384.4" "1362.5" "1335.9" "1322.0" "1341.5" "1232.1" "1345.4" "1245.4" "1339.7" "" "" "" "" "" "" "" "" "" "" "1095.1" "998.9" "1082.2" "895.0" "914.3" "1006.5" "862.6" "982.6" "1245.4" "1089.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8467787264096672406" "False" "High" "IsMasterProtein" "O00506" "Serine/threonine-protein kinase 25 OS=Homo sapiens OX=9606 GN=STK25 PE=1 SV=1" "0.000" "False" "48.573" "18" "7" "13" "4" "426" "48.1" "6.74" "44.09" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "10494" "ENSG00000115694" "STK25" "A8K6Z3; A8K7D2; B7Z9K1; hsa:10494; O00506; Q15522; Q5BJF1" "" "2q37 copy number variation syndrome" "1" "0" "1.098" "1.034" "0.963" "0.961" "0.959" "0.951" "0.913" "1.024" "0.914" "236.3" "259.4" "244.3" "227.5" "227.1" "226.7" "224.8" "215.9" "242.1" "216.1" "" "" "" "" "" "" "" "" "" "" "189.8" "187.2" "194.0" "152.4" "157.1" "170.1" "157.4" "157.6" "242.1" "175.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7328219287373480262" "False" "High" "IsMasterProtein" "Q7LG56" "Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1" "0.000" "False" "48.536" "27" "8" "15" "6" "351" "40.7" "4.97" "53.79" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00268" "50484" "ENSG00000048392" "RRM2B" "B4E2N4; hsa:50484; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q7LG56; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3" "TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates" "miRNA regulation of DNA damage response; Pyrimidine metabolism; p53 transcriptional gene network; DNA damage response" "6" "0" "1.037" "1.006" "0.917" "0.964" "0.966" "0.940" "1.015" "0.956" "0.990" "820.5" "850.6" "825.4" "752.6" "790.9" "792.7" "771.3" "832.9" "784.3" "812.2" "" "" "" "" "" "" "" "" "" "" "659.0" "613.8" "655.7" "504.2" "547.0" "594.7" "540.0" "608.3" "784.3" "660.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2648921608470054018" "False" "High" "IsMasterProtein" "Q96L92" "Sorting nexin-27 OS=Homo sapiens OX=9606 GN=SNX27 PE=1 SV=2" "0.000" "False" "48.467" "23" "11" "14" "10" "541" "61.2" "6.49" "46.77" "11" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595, Pf00787, Pf00788" "81609" "ENSG00000143376" "SNX27" "hsa:81609; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q96L92; Q9H3K8" "" "" "0" "1" "0.991" "1.019" "0.978" "0.983" "0.986" "1.027" "0.948" "0.974" "0.970" "1194.2" "1183.7" "1216.9" "1168.0" "1174.2" "1177.1" "1225.9" "1131.5" "1162.8" "1158.1" "" "" "" "" "" "" "" "" "" "" "959.2" "854.1" "966.6" "782.6" "812.1" "883.1" "858.3" "826.4" "1162.8" "941.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9042131036706186365" "False" "High" "IsMasterProtein" "Q13485" "Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1" "0.000" "False" "48.448" "21" "11" "15" "11" "552" "60.4" "6.99" "47.95" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4089" "ENSG00000141646" "SMAD4" "A8K405; hsa:4089; Q13485" "Ub-specific processing proteases; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by BMP; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Transcriptional regulation of pluripotent stem cells; RUNX3 regulates BCL2L11 (BIM) transcription; RUNX2 regulates bone development; Signaling by Activin; TGF-beta receptor signaling activates SMADs; RUNX3 regulates CDKN1A transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Heart development; Cell cycle; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Progeria-associated lipodystrophy; Clock-controlled autophagy in bone metabolism; Rubinstein-Taybi syndrome 1; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "53" "0" "1.101" "1.042" "1.080" "1.014" "1.051" "0.971" "0.989" "1.045" "1.095" "760.5" "837.1" "792.5" "821.4" "771.3" "798.9" "738.8" "752.1" "794.6" "832.6" "" "" "" "" "" "" "" "" "" "" "610.8" "604.0" "629.5" "550.3" "533.5" "599.4" "517.3" "549.3" "794.6" "677.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3614438977501336635" "False" "High" "IsMasterProtein" "Q92558" "Actin-binding protein WASF1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "0.000" "False" "48.380" "13" "7" "10" "7" "559" "61.6" "6.46" "38.65" "7" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "8" "0" "1.035" "0.975" "1.139" "1.015" "0.927" "0.969" "0.975" "1.023" "1.028" "643.8" "666.1" "627.4" "733.2" "653.7" "596.9" "623.7" "627.5" "658.3" "662.1" "" "" "" "" "" "" "" "" "" "" "517.1" "480.6" "498.4" "491.3" "452.1" "447.9" "436.7" "458.3" "658.3" "538.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8485844677282632680" "False" "High" "IsMasterProtein" "Q99717" "Mothers against decapentaplegic homolog 5 OS=Homo sapiens OX=9606 GN=SMAD5 PE=1 SV=1" "0.000" "False" "48.363" "20" "8" "16" "7" "465" "52.2" "7.71" "46.99" "8" "developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4090" "ENSG00000113658" "SMAD5" "hsa:4090; O14688; Q15798; Q99717; Q9UQA1" "Signaling by BMP" "Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Neovascularization processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Network map of SARS-CoV-2 signaling pathway; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; TGF-beta receptor signaling" "14" "1" "0.930" "0.926" "1.030" "0.875" "0.966" "0.920" "0.981" "0.980" "0.967" "538.9" "501.0" "498.9" "554.9" "471.7" "520.6" "495.7" "528.9" "528.1" "520.9" "" "" "" "" "" "" "" "" "" "" "432.8" "361.5" "396.3" "371.8" "326.2" "390.6" "347.1" "386.2" "528.1" "423.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3479204083364141985" "False" "High" "IsMasterProtein" "Q96IY1" "Kinetochore-associated protein NSL1 homolog OS=Homo sapiens OX=9606 GN=NSL1 PE=1 SV=3" "0.000" "False" "48.346" "25" "6" "8" "6" "281" "32.1" "6.79" "34.90" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf08641" "25936" "ENSG00000117697" "NSL1" "E7ETD5; hsa:25936; Q5SY75; Q96IY1; Q9H2M5; Q9NRN8; Q9Y415" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.030" "0.946" "1.123" "1.179" "1.092" "0.996" "1.059" "1.004" "0.974" "189.7" "195.3" "179.4" "213.0" "223.7" "207.2" "189.0" "200.9" "190.4" "184.8" "" "" "" "" "" "" "" "" "" "" "152.4" "140.9" "142.5" "142.7" "154.7" "155.4" "132.3" "146.7" "190.4" "150.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8722067118007621165" "False" "High" "IsMasterProtein" "P23497" "Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3" "0.000" "False" "48.303" "14" "10" "15" "7" "879" "100.4" "8.22" "49.25" "10" "cell organization and biogenesis;DNA metabolism;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01342, Pf03172, Pf09011" "6672" "ENSG00000067066" "SP100" "B4DDX5; B8ZZD8; E7EUA7; E9PH61; F8WFE2; hsa:6672; O75450; P23497; Q13343; Q8TE34; Q96F70; Q96T24; Q96T95; Q9NP33; Q9UE32" "SUMOylation of DNA damage response and repair proteins; Interferon gamma signaling" "" "2" "2" "1.166" "1.056" "1.046" "1.134" "1.169" "1.127" "1.135" "1.113" "1.100" "1101.7" "1284.7" "1163.0" "1152.7" "1249.8" "1287.4" "1242.0" "1250.2" "1225.8" "1212.1" "" "" "" "" "" "" "" "" "" "" "884.9" "927.0" "923.8" "772.3" "864.4" "965.9" "869.6" "913.1" "1225.8" "985.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5073984553663010392" "False" "High" "IsMasterProtein" "Q86UV5" "Ubiquitin carboxyl-terminal hydrolase 48 OS=Homo sapiens OX=9606 GN=USP48 PE=1 SV=1" "0.000" "False" "48.298" "11" "11" "12" "11" "1035" "119.0" "6.05" "40.10" "11" "protein metabolism" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00443, Pf06337" "84196" "ENSG00000090686" "USP48" "B7ZKS7; hsa:84196; Q2M3I4; Q5SZI4; Q5T3T5; Q6NX53; Q86UV5; Q8N3F6; Q96F64; Q96IQ3; Q9H5N3; Q9H5T7; Q9NUJ6; Q9NXR0" "Ub-specific processing proteases" "" "1" "0" "0.967" "0.954" "0.972" "0.997" "0.985" "0.929" "1.031" "1.034" "0.992" "1481.9" "1433.5" "1414.1" "1440.6" "1477.2" "1460.0" "1376.1" "1528.1" "1533.0" "1470.0" "" "" "" "" "" "" "" "" "" "" "1190.2" "1034.4" "1123.3" "965.2" "1021.6" "1095.4" "963.4" "1116.0" "1533.0" "1195.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2125908269399926840" "False" "High" "IsMasterProtein" "Q9UKK3" "Protein mono-ADP-ribosyltransferase PARP4 OS=Homo sapiens OX=9606 GN=PARP4 PE=1 SV=3" "0.000" "False" "48.279" "8" "13" "14" "13" "1724" "192.5" "5.66" "40.34" "13" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00092, Pf00533, Pf00644, Pf08487" "143" "ENSG00000102699" "PARP4" "hsa:143; O75903; Q14682; Q5QNZ9; Q9H1M6; Q9UKK3" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome" "5" "0" "1.019" "0.962" "0.995" "0.977" "1.020" "0.986" "1.092" "1.008" "1.045" "611.9" "623.3" "588.7" "608.7" "597.8" "623.9" "603.6" "668.0" "617.0" "639.4" "" "" "" "" "" "" "" "" "" "" "491.5" "449.8" "467.6" "407.8" "413.5" "468.1" "422.6" "487.8" "617.0" "520.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6803776007100694472" "False" "High" "IsMasterProtein" "P51580" "Thiopurine S-methyltransferase OS=Homo sapiens OX=9606 GN=TPMT PE=1 SV=1" "0.000" "False" "48.276" "37" "8" "10" "8" "245" "28.2" "6.23" "40.04" "8" "other metabolic processes" "cytosol" "other molecular function" "Pf05724" "7172" "ENSG00000137364" "TPMT" "hsa:7172; O14806; O15423; O15424; O15425; O15426; O15515; O15548; O43213; P51580; Q5VUK6; Q9UBE6; Q9UBT8; Q9UE62" "Azathioprine ADME; Methylation; Defective TPMT causes TPMT deficiency" "Metapathway biotransformation Phase I and II; Methylation pathways" "5" "0" "0.958" "0.946" "0.971" "0.997" "0.958" "0.964" "1.031" "1.022" "1.011" "704.9" "675.0" "666.9" "684.2" "702.9" "675.6" "679.4" "726.9" "720.8" "712.5" "" "" "" "" "" "" "" "" "" "" "566.2" "487.1" "529.8" "458.4" "486.1" "506.9" "475.7" "530.9" "720.8" "579.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6604733771635373365" "False" "High" "IsMasterProtein" "P84085" "ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2" "0.000" "False" "48.222" "48" "8" "22" "3" "180" "20.5" "6.79" "73.77" "8" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "381" "ENSG00000004059" "ARF5" "hsa:381; P26437; P84085" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "2q37 copy number variation syndrome" "3" "1" "0.983" "0.970" "0.959" "0.995" "0.897" "0.887" "1.010" "0.994" "0.904" "1633.4" "1605.2" "1583.7" "1567.0" "1626.0" "1465.7" "1448.1" "1649.2" "1623.3" "1475.9" "" "" "" "" "" "" "" "" "" "" "1312.0" "1158.3" "1258.0" "1049.9" "1124.6" "1099.7" "1013.9" "1204.4" "1623.3" "1200.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7020268087964795198" "False" "High" "IsMasterProtein" "Q9Y3B7" "Large ribosomal subunit protein uL11m OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "0.000" "False" "48.219" "42" "8" "12" "8" "192" "20.7" "9.91" "38.93" "8" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.990" "0.992" "0.971" "1.032" "1.048" "0.933" "0.954" "0.999" "0.973" "1324.0" "1310.1" "1313.8" "1285.5" "1366.9" "1388.0" "1235.3" "1262.7" "1322.7" "1287.6" "" "" "" "" "" "" "" "" "" "" "1063.4" "945.3" "1043.6" "861.3" "945.4" "1041.4" "864.9" "922.2" "1322.7" "1047.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2347983332977388865" "False" "High" "IsMasterProtein" "Q9H900" "Protein zwilch homolog OS=Homo sapiens OX=9606 GN=ZWILCH PE=1 SV=2" "0.000" "False" "48.185" "16" "9" "13" "9" "591" "67.2" "6.27" "40.29" "9" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf09817" "55055" "ENSG00000174442" "ZWILCH" "B3KVB8; hsa:55055; Q6N049; Q8N404; Q96SY7; Q9H900; Q9NWG7" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.987" "1.036" "0.939" "0.970" "0.969" "0.974" "1.042" "0.993" "0.990" "1173.9" "1158.3" "1216.1" "1102.1" "1138.3" "1137.8" "1143.9" "1222.9" "1165.8" "1162.1" "" "" "" "" "" "" "" "" "" "" "942.9" "835.8" "966.0" "738.4" "787.3" "853.7" "800.9" "893.1" "1165.8" "945.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6270565792586481652" "False" "High" "IsMasterProtein" "Q9UHY7" "Enolase-phosphatase E1 OS=Homo sapiens OX=9606 GN=ENOPH1 PE=1 SV=1" "0.000" "False" "48.163" "38" "8" "19" "8" "261" "28.9" "4.78" "58.11" "8" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00702" "58478" "ENSG00000145293" "ENOPH1" "hsa:58478; Q7Z4C5; Q9BVC2; Q9UHY7" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "0.975" "0.997" "0.945" "0.985" "1.006" "0.912" "0.922" "0.943" "0.950" "1255.0" "1224.1" "1251.4" "1186.6" "1236.4" "1262.5" "1144.6" "1157.6" "1183.4" "1191.7" "" "" "" "" "" "" "" "" "" "" "1008.0" "883.3" "994.1" "795.0" "855.1" "947.3" "801.4" "845.4" "1183.4" "969.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3380259188437483549" "False" "High" "IsMasterProtein" "Q9NQ88" "Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1" "0.000" "False" "48.116" "46" "9" "11" "9" "270" "30.0" "7.69" "34.48" "9" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00300" "57103" "ENSG00000078237" "TIGAR" "B2R840; hsa:57103; Q9NQ88" "TP53 Regulates Metabolic Genes" "Metabolic reprogramming in colon cancer; p53 transcriptional gene network" "3" "0" "0.975" "0.962" "0.985" "0.968" "0.952" "0.988" "0.998" "0.919" "0.960" "603.5" "588.7" "580.7" "594.5" "584.3" "574.4" "596.0" "602.6" "554.4" "579.5" "" "" "" "" "" "" "" "" "" "" "484.8" "424.8" "461.3" "398.3" "404.1" "430.9" "417.3" "440.1" "554.4" "471.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6418921267369266529" "False" "High" "IsMasterProtein" "P31321" "cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4" "0.000" "False" "48.079" "34" "10" "13" "7" "381" "43.0" "5.71" "42.62" "10" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5575" "ENSG00000188191" "PRKAR1B" "hsa:5575; P31321; Q8N422" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "21" "0" "0.999" "0.998" "1.019" "1.016" "0.996" "0.962" "1.039" "1.044" "0.941" "530.8" "530.2" "529.5" "541.0" "539.1" "528.7" "510.5" "551.5" "554.4" "499.2" "" "" "" "" "" "" "" "" "" "" "426.3" "382.6" "420.6" "362.4" "372.8" "396.7" "357.4" "402.8" "554.4" "406.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7606738261010209794" "False" "High" "IsMasterProtein" "Q7Z569" "BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2" "0.000" "False" "48.065" "17" "8" "10" "8" "592" "67.3" "5.92" "36.01" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02148, Pf07576, Pf13639" "8315" "ENSG00000089234" "BRAP" "B4DRM1; B9EGS8; hsa:8315; O43238; O75341; Q7Z569" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Negative regulation of MAPK pathway" "Ras signaling" "6" "0" "1.191" "1.002" "1.204" "0.982" "1.043" "0.991" "0.966" "1.077" "1.081" "574.0" "683.8" "574.9" "691.0" "563.6" "598.5" "568.6" "554.3" "618.0" "620.2" "" "" "" "" "" "" "" "" "" "" "461.0" "493.4" "456.6" "463.0" "389.8" "449.1" "398.1" "404.8" "618.0" "504.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1864840127282000894" "False" "High" "IsMasterProtein" "Q9Y2I1" "Nischarin OS=Homo sapiens OX=9606 GN=NISCH PE=1 SV=3" "0.000" "False" "47.968" "9" "11" "12" "11" "1504" "166.5" "5.14" "32.24" "11" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787" "11188" "ENSG00000010322" "NISCH" "C9J245; hsa:11188; Q6PGP3; Q6PIB4; Q7L8M3; Q7Z2X6; Q9UES6; Q9UEU4; Q9UFW3; Q9Y2I1" "RND2 GTPase cycle; RAC1 GTPase cycle; RND3 GTPase cycle" "" "3" "0" "1.049" "0.976" "1.046" "1.027" "1.018" "1.040" "1.001" "1.121" "1.023" "851.6" "893.4" "831.2" "890.4" "874.9" "867.3" "885.9" "852.6" "954.8" "871.2" "" "" "" "" "" "" "" "" "" "" "684.0" "644.7" "660.2" "596.6" "605.1" "650.7" "620.3" "622.6" "954.8" "708.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235464357787345308" "False" "High" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "0.000" "False" "47.937" "49" "5" "14" "5" "118" "13.1" "4.88" "52.21" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Evasion by RSV of host interferon responses" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "22" "0" "1.167" "1.020" "1.099" "0.941" "1.065" "0.991" "1.118" "0.960" "1.047" "1677.7" "1958.1" "1711.0" "1843.2" "1578.2" "1786.7" "1662.3" "1875.2" "1611.1" "1756.7" "" "" "" "" "" "" "" "" "" "" "1347.5" "1412.9" "1359.1" "1235.0" "1091.5" "1340.5" "1163.9" "1369.5" "1611.1" "1428.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585562482268553685" "False" "High" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "0.000" "False" "47.927" "18" "6" "13" "6" "352" "39.9" "6.54" "54.62" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "10" "0" "0.854" "1.071" "0.995" "1.003" "1.020" "1.058" "1.138" "1.078" "1.015" "1381.0" "1178.8" "1479.3" "1374.5" "1384.5" "1408.2" "1461.4" "1571.0" "1488.8" "1401.2" "" "" "" "" "" "" "" "" "" "" "1109.2" "850.6" "1175.0" "920.9" "957.5" "1056.6" "1023.2" "1147.3" "1488.8" "1139.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097285546309815512" "False" "High" "IsMasterProtein" "Q8NEB9" "Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1" "0.000" "False" "47.924" "11" "10" "13" "10" "887" "101.5" "6.81" "36.99" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792" "5289" "ENSG00000078142" "PIK3C3" "hsa:5289; Q15134; Q8NEB9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "AMP-activated protein kinase signaling; Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Microglia pathogen phagocytosis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "24" "0" "1.005" "1.010" "0.973" "0.977" "0.961" "0.910" "1.012" "0.985" "1.046" "1357.2" "1363.4" "1370.5" "1321.2" "1325.5" "1304.5" "1234.7" "1373.3" "1336.8" "1419.3" "" "" "" "" "" "" "" "" "" "" "1090.1" "983.8" "1088.6" "885.2" "916.7" "978.8" "864.5" "1002.9" "1336.8" "1154.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7454062146017555339" "False" "High" "IsMasterProtein" "P32019" "Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4" "0.000" "False" "47.750" "11" "12" "16" "12" "993" "112.8" "5.57" "47.64" "12" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00620, Pf16776, Pf21310" "3633" "ENSG00000204084" "INPP5B" "C9J6U5; hsa:3633; P32019; Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1" "Synthesis of IP2, IP, and Ins in the cytosol; Synthesis of IP3 and IP4 in the cytosol" "" "2" "0" "0.988" "0.961" "0.946" "0.983" "0.941" "0.904" "0.933" "0.926" "0.930" "1151.8" "1137.8" "1107.2" "1090.1" "1131.7" "1083.5" "1040.9" "1074.6" "1066.1" "1070.9" "" "" "" "" "" "" "" "" "" "" "925.1" "821.0" "879.5" "730.3" "782.7" "813.0" "728.8" "784.8" "1066.1" "870.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174641781052764353" "False" "High" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "0.000" "False" "47.708" "34" "10" "17" "10" "348" "37.9" "7.23" "46.77" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "Purine salvage" "" "1" "0" "0.948" "1.015" "0.925" "0.976" "1.027" "0.904" "0.909" "0.978" "0.977" "1101.7" "1043.9" "1118.3" "1018.7" "1074.9" "1131.9" "996.4" "1001.4" "1077.0" "1076.8" "" "" "" "" "" "" "" "" "" "" "884.9" "753.2" "888.3" "682.6" "743.4" "849.3" "697.6" "731.3" "1077.0" "875.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7556916282893625233" "False" "High" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "0.000" "False" "47.681" "34" "5" "8" "4" "200" "23.0" "8.37" "30.95" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "1.007" "0.984" "1.018" "0.979" "0.964" "0.899" "1.022" "0.898" "0.950" "886.0" "892.0" "871.8" "901.8" "867.7" "853.8" "796.8" "905.5" "795.9" "841.3" "" "" "" "" "" "" "" "" "" "" "711.6" "643.7" "692.5" "604.2" "600.1" "640.6" "557.9" "661.3" "795.9" "684.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2868911152044451366" "False" "High" "IsMasterProtein" "Q99570" "Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3" "0.000" "False" "47.658" "10" "12" "17" "12" "1358" "153.0" "7.17" "45.37" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00400" "30849" "ENSG00000196455" "PIK3R4" "hsa:30849; Q2TBF4; Q99570" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PI3K Cascade; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "25" "0" "0.999" "1.021" "1.047" "0.973" "0.997" "0.970" "0.999" "1.053" "1.005" "1226.9" "1225.3" "1252.1" "1284.2" "1193.6" "1223.1" "1190.6" "1225.6" "1291.7" "1233.4" "" "" "" "" "" "" "" "" "" "" "985.4" "884.1" "994.6" "860.4" "825.5" "917.7" "833.6" "895.0" "1291.7" "1003.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2257664793413269493" "False" "High" "IsMasterProtein" "Q69YN2" "CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2" "0.000" "False" "47.652" "19" "9" "14" "9" "538" "60.6" "7.24" "45.79" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity" "Pf04676, Pf04677" "55280" "ENSG00000095485" "CWF19L1" "B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13" "" "" "0" "0" "0.940" "0.928" "0.963" "0.972" "0.954" "0.947" "0.968" "0.905" "0.953" "1347.9" "1267.5" "1250.4" "1297.9" "1310.3" "1286.5" "1276.8" "1305.3" "1220.5" "1284.3" "" "" "" "" "" "" "" "" "" "" "1082.7" "914.6" "993.2" "869.6" "906.2" "965.3" "893.9" "953.3" "1220.5" "1044.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7438852567896609676" "False" "High" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "0.000" "False" "47.593" "37" "9" "12" "9" "327" "36.1" "5.73" "39.26" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "6" "0" "0.961" "0.990" "0.956" "0.973" "0.994" "0.940" "1.023" "0.964" "0.995" "758.7" "729.1" "750.8" "725.1" "738.3" "753.9" "713.2" "776.3" "731.5" "755.1" "" "" "" "" "" "" "" "" "" "" "609.3" "526.1" "596.4" "485.8" "510.6" "565.7" "499.3" "566.9" "731.5" "614.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6609542144732775052" "False" "High" "IsMasterProtein" "Q92615" "La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3" "0.000" "False" "47.553" "10" "7" "10" "7" "738" "80.5" "6.92" "39.16" "7" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05383" "23185" "ENSG00000107929" "LARP4B" "A7MD20; hsa:23185; Q5T3R3; Q5T3R4; Q5T3R5; Q68CY4; Q92615" "" "" "0" "0" "1.016" "1.073" "1.054" "1.141" "1.031" "1.116" "1.145" "1.050" "1.108" "649.4" "659.9" "697.1" "684.5" "741.1" "669.6" "724.8" "743.8" "681.9" "719.8" "" "" "" "" "" "" "" "" "" "" "521.6" "476.1" "553.7" "458.6" "512.5" "502.4" "507.5" "543.2" "681.9" "585.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549741875275556482" "False" "High" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "0.000" "False" "47.551" "24" "3" "9" "3" "209" "23.2" "5.38" "40.43" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Neddylation; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "Ciliary landscape; 2q37 copy number variation syndrome" "6" "0" "1.145" "1.045" "1.055" "1.132" "1.059" "1.091" "1.088" "1.097" "1.108" "568.7" "650.9" "594.4" "599.9" "643.6" "602.2" "620.5" "618.5" "623.9" "630.0" "" "" "" "" "" "" "" "" "" "" "456.8" "469.7" "472.1" "401.9" "445.1" "451.8" "434.4" "451.7" "623.9" "512.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6603036499622523787" "False" "High" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "0.000" "False" "47.505" "33" "11" "16" "11" "368" "42.0" "8.63" "53.95" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "1.022" "1.020" "1.047" "1.154" "1.116" "1.033" "1.026" "0.989" "1.044" "858.0" "876.9" "875.1" "898.7" "990.1" "957.3" "886.7" "880.4" "848.4" "896.2" "" "" "" "" "" "" "" "" "" "" "689.2" "632.7" "695.1" "602.1" "684.8" "718.2" "620.8" "643.0" "848.4" "728.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7356302297912569782" "False" "High" "IsMasterProtein" "O75400" "Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2" "0.000" "False" "47.503" "10" "9" "12" "9" "957" "108.7" "7.56" "39.46" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00397, Pf01846" "55660" "ENSG00000196504" "PRPF40A" "hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.949" "1.046" "1.011" "1.043" "1.142" "1.097" "1.124" "1.133" "1.038" "561.4" "532.9" "587.2" "567.6" "585.8" "640.9" "615.9" "631.2" "635.8" "582.5" "" "" "" "" "" "" "" "" "" "" "450.9" "384.5" "466.4" "380.3" "405.1" "480.9" "431.2" "460.9" "635.8" "473.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516330367870273472" "False" "High" "IsMasterProtein" "P09086" "POU domain, class 2, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU2F2 PE=1 SV=3" "0.000" "False" "47.494" "19" "7" "11" "4" "479" "51.2" "8.43" "36.51" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "5452" "ENSG00000028277" "POU2F2" "hsa:5452; P09086; Q16648; Q7M4M8; Q9BRS4" "RNA polymerase II transcribes snRNA genes" "Ectoderm differentiation; Prion disease pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "4" "0" "0.972" "1.001" "1.018" "0.878" "0.944" "0.856" "0.929" "0.889" "1.010" "203.7" "198.0" "203.8" "207.5" "178.9" "192.4" "174.3" "189.2" "181.1" "205.7" "" "" "" "" "" "" "" "" "" "" "163.6" "142.8" "161.9" "139.0" "123.7" "144.3" "122.0" "138.2" "181.1" "167.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802113826893248650" "False" "High" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "0.000" "False" "47.441" "41" "2" "16" "2" "87" "10.0" "6.57" "64.54" "2" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Mitochondrial Fatty Acid Beta-Oxidation" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "6" "0" "1.011" "1.090" "0.991" "1.070" "1.146" "1.059" "1.123" "1.111" "1.116" "1974.1" "1996.4" "2151.3" "1956.5" "2111.5" "2263.1" "2091.1" "2217.2" "2192.8" "2203.4" "" "" "" "" "" "" "" "" "" "" "1585.6" "1440.6" "1708.8" "1310.9" "1460.4" "1698.0" "1464.1" "1619.2" "2192.8" "1791.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4429006779143257910" "False" "High" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "0.000" "False" "47.393" "27" "9" "14" "9" "339" "40.2" "6.83" "40.40" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "mRNA Splicing - Major Pathway" "" "1" "0" "1.050" "0.999" "1.033" "1.053" "0.996" "0.979" "1.027" "1.030" "1.000" "1343.3" "1410.4" "1342.5" "1387.8" "1414.2" "1337.6" "1314.6" "1379.6" "1383.2" "1343.4" "" "" "" "" "" "" "" "" "" "" "1078.9" "1017.7" "1066.4" "929.8" "978.1" "1003.6" "920.4" "1007.6" "1383.2" "1092.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8162183631045646946" "False" "High" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "0.000" "False" "47.378" "30" "8" "13" "6" "375" "41.6" "7.74" "46.30" "8" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "FGFR2 alternative splicing" "" "1" "2" "1.003" "1.008" "0.971" "0.957" "1.005" "1.010" "1.021" "0.987" "1.011" "1642.7" "1647.3" "1655.8" "1594.7" "1572.2" "1651.6" "1658.9" "1676.4" "1621.7" "1660.8" "" "" "" "" "" "" "" "" "" "" "1319.4" "1188.6" "1315.3" "1068.5" "1087.3" "1239.2" "1161.5" "1224.3" "1621.7" "1350.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2849598886551382800" "False" "High" "IsMasterProtein" "Q9P2K5" "Myelin expression factor 2 OS=Homo sapiens OX=9606 GN=MYEF2 PE=1 SV=3" "0.000" "False" "47.356" "19" "10" "12" "10" "600" "64.1" "8.75" "35.69" "10" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "50804" "ENSG00000104177" "MYEF2" "A7MCZ9; C9J921; C9K0J4; hsa:50804; Q6NUM5; Q7L388; Q7Z4B7; Q9H922; Q9NUQ1; Q9P2K5" "" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression" "4" "0" "1.100" "0.989" "1.056" "1.165" "1.072" "0.995" "1.040" "1.031" "1.063" "933.2" "1026.7" "922.8" "985.1" "1087.7" "1000.3" "928.3" "971.0" "962.4" "991.6" "" "" "" "" "" "" "" "" "" "" "749.6" "740.8" "733.0" "660.1" "752.2" "750.5" "650.0" "709.1" "962.4" "806.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6373190460563601224" "False" "High" "IsMasterProtein" "Q7L014" "Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2" "0.000" "False" "47.310" "14" "14" "16" "14" "1031" "117.3" "9.29" "45.36" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus" "other molecular function" "Pf00270, Pf00271" "9879" "ENSG00000145833" "DDX46" "hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658" "mRNA Splicing - Major Pathway" "" "1" "0" "1.039" "1.113" "1.074" "0.963" "1.054" "1.078" "1.185" "1.193" "1.111" "603.6" "627.0" "672.0" "648.0" "581.0" "636.2" "650.5" "715.4" "720.2" "670.6" "" "" "" "" "" "" "" "" "" "" "484.8" "452.4" "533.8" "434.2" "401.8" "477.4" "455.4" "522.5" "720.2" "545.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3180744532399736086" "False" "High" "IsMasterProtein" "Q15814" "Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2" "0.000" "False" "47.279" "27" "11" "15" "10" "346" "39.2" "5.71" "57.32" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07986, Pf16752" "6903" "ENSG00000124659" "TBCC" "hsa:6903; Q15814; Q53Y43; Q5T787" "Post-chaperonin tubulin folding pathway" "" "1" "0" "1.166" "0.961" "1.103" "1.063" "1.040" "1.069" "1.075" "1.053" "1.045" "660.8" "770.2" "634.8" "728.5" "702.7" "686.9" "706.6" "710.5" "695.6" "690.7" "" "" "" "" "" "" "" "" "" "" "530.7" "555.8" "504.2" "488.1" "486.0" "515.4" "494.8" "518.9" "695.6" "561.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502282286759796404" "False" "High" "IsMasterProtein" "O00411" "DNA-directed RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2" "0.000" "False" "47.273" "12" "11" "14" "11" "1230" "138.5" "8.98" "38.81" "11" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00940, Pf14700" "5442" "ENSG00000099821" "POLRMT" "hsa:5442; O00411; O60370" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "Mitochondrial gene expression" "3" "0" "0.960" "0.928" "1.059" "1.012" "0.958" "0.925" "0.955" "1.007" "0.964" "778.6" "747.6" "722.7" "824.6" "788.3" "746.3" "720.5" "743.8" "784.4" "750.9" "" "" "" "" "" "" "" "" "" "" "625.4" "539.5" "574.1" "552.5" "545.2" "559.9" "504.4" "543.2" "784.4" "610.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3468928122779261644" "False" "High" "IsMasterProtein" "P51398" "Small ribosomal subunit protein mS29 OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "0.000" "False" "47.247" "21" "7" "9" "7" "398" "45.5" "8.88" "30.10" "7" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.006" "0.955" "0.965" "0.960" "1.030" "0.879" "0.995" "0.983" "1.009" "726.7" "731.2" "693.9" "701.3" "697.9" "748.2" "638.8" "723.2" "714.3" "733.1" "" "" "" "" "" "" "" "" "" "" "583.7" "527.6" "551.2" "469.9" "482.7" "561.3" "447.3" "528.1" "714.3" "596.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066776278631376418" "False" "High" "IsMasterProtein" "P17612" "cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2" "0.000" "False" "47.219" "27" "10" "14" "5" "351" "40.6" "8.79" "50.19" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5566" "ENSG00000072062; ENSG00000288516" "PRKACA" "hsa:5566; P17612; Q32P54; Q9H2Y0; Q9NRB4; Q9NRH9" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Mitochondrial protein degradation; FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Phosphodiesterases in neuronal function; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; GDNF signaling; Urotensin-II-mediated signaling pathway; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "75" "4" "0.934" "0.976" "1.005" "0.945" "0.976" "1.023" "0.955" "0.967" "0.974" "1333.2" "1245.8" "1301.7" "1339.8" "1259.8" "1300.7" "1364.2" "1273.8" "1288.5" "1299.1" "" "" "" "" "" "" "" "" "" "" "1070.8" "898.9" "1033.9" "897.7" "871.3" "975.9" "955.2" "930.3" "1288.5" "1056.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6575601821171362980" "False" "High" "IsMasterProtein" "P39019" "Small ribosomal subunit protein eS19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "0.000" "False" "47.192" "35" "5" "18" "5" "145" "16.1" "10.32" "43.06" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Complement system; Cytoplasmic ribosomal proteins" "20" "0" "0.951" "1.241" "1.190" "1.073" "1.164" "1.250" "1.127" "1.159" "1.066" "754.3" "717.2" "936.1" "897.5" "809.5" "877.9" "943.2" "849.8" "874.2" "804.1" "" "" "" "" "" "" "" "" "" "" "605.9" "517.5" "743.6" "601.4" "559.9" "658.7" "660.4" "620.6" "874.2" "653.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4989435524198560061" "False" "High" "IsMasterProtein" "P48506" "Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2" "0.000" "False" "47.189" "15" "8" "14" "8" "637" "72.7" "6.09" "59.44" "8" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03074" "2729" "ENSG00000001084" "GCLC" "hsa:2729; P48506; Q14399" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "17" "0" "0.998" "1.025" "0.917" "0.918" "0.991" "0.884" "0.933" "0.933" "0.974" "1379.1" "1377.0" "1413.5" "1264.4" "1266.5" "1367.0" "1219.4" "1286.7" "1286.1" "1343.6" "" "" "" "" "" "" "" "" "" "" "1107.7" "993.6" "1122.8" "847.2" "875.9" "1025.6" "853.8" "939.7" "1286.1" "1092.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6260636582982827540" "False" "High" "IsMasterProtein" "Q6YHU6" "tRNA (32-2'-O)-methyltransferase regulator THADA OS=Homo sapiens OX=9606 GN=THADA PE=1 SV=1" "0.000" "False" "47.174" "7" "13" "13" "13" "1953" "219.5" "6.06" "40.32" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity" "Pf10350" "63892" "ENSG00000115970" "THADA" "A8K1V8; B7WNS6; hsa:63892; Q3KR04; Q53RC6; Q53TB2; Q6YHU2; Q6YHU6; Q6ZU38; Q8IY32; Q8TAU8; Q96I88; Q9BZF7; Q9C096; Q9H6U0; Q9H6W7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.018" "1.011" "0.967" "1.010" "1.017" "0.958" "0.937" "1.007" "1.019" "1010.9" "1029.0" "1021.6" "977.9" "1021.3" "1028.5" "968.7" "947.6" "1018.4" "1029.7" "" "" "" "" "" "" "" "" "" "" "812.0" "742.5" "811.5" "655.2" "706.3" "771.7" "678.2" "692.0" "1018.4" "837.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2063418146080875135" "False" "High" "IsMasterProtein" "O76094" "Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3" "0.000" "False" "47.162" "11" "7" "8" "7" "671" "74.6" "9.26" "33.75" "7" "other biological processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08492, Pf13181, Pf17004" "6731" "ENSG00000174780" "SRP72" "G5E9Z8; hsa:6731; O76094; Q7Z3C0" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "1.125" "1.107" "1.090" "1.081" "1.067" "1.015" "1.125" "1.166" "1.089" "603.9" "679.4" "668.4" "658.4" "652.7" "644.4" "613.2" "679.4" "704.4" "657.4" "" "" "" "" "" "" "" "" "" "" "485.1" "490.2" "530.9" "441.1" "451.4" "483.5" "429.3" "496.2" "704.4" "534.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188184621199488866" "False" "High" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "0.000" "False" "47.150" "62" "6" "14" "6" "109" "12.3" "10.24" "52.61" "6" "other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "Mitochondrial RNA degradation" "" "1" "0" "0.954" "0.993" "0.999" "1.043" "0.989" "0.963" "0.932" "0.925" "0.982" "1178.9" "1124.6" "1170.6" "1178.2" "1230.0" "1165.4" "1135.2" "1098.3" "1090.0" "1157.7" "" "" "" "" "" "" "" "" "" "" "946.9" "811.5" "929.8" "789.4" "850.6" "874.4" "794.8" "802.1" "1090.0" "941.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386801928701098306" "False" "High" "IsMasterProtein" "Q6ULP2" "Aftiphilin OS=Homo sapiens OX=9606 GN=AFTPH PE=1 SV=3" "0.000" "False" "47.061" "12" "9" "13" "9" "936" "102.1" "4.54" "40.29" "9" "transport" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15045" "54812" "ENSG00000119844" "AFTPH" "D6W5E9; hsa:54812; Q6ULP2; Q6ZM66; Q86VW3; Q8TCF3; Q9H7E3; Q9HAB9; Q9NXS4" "" "" "0" "0" "1.031" "0.956" "1.046" "0.987" "0.974" "1.027" "0.998" "1.037" "1.010" "371.0" "382.4" "354.7" "388.0" "366.3" "361.3" "380.9" "370.2" "384.7" "374.9" "" "" "" "" "" "" "" "" "" "" "298.0" "276.0" "281.7" "260.0" "253.3" "271.0" "266.7" "270.4" "384.7" "304.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366050407919946154" "False" "High" "IsMasterProtein" "Q96II8" "DISP complex protein LRCH3 OS=Homo sapiens OX=9606 GN=LRCH3 PE=1 SV=2" "0.000" "False" "47.042" "14" "10" "12" "10" "777" "86.0" "6.71" "45.48" "10" "cell organization and biogenesis" "cytosol;other cell component" "" "Pf00307, Pf13855" "84859" "ENSG00000186001" "LRCH3" "B4E0T7; hsa:84859; Q96FP9; Q96II8; Q9NT52" "" "" "0" "0" "1.029" "1.017" "1.027" "0.964" "0.980" "0.995" "1.048" "1.062" "1.006" "697.5" "717.4" "709.4" "716.5" "672.7" "683.4" "694.1" "730.6" "740.9" "701.8" "" "" "" "" "" "" "" "" "" "" "560.2" "517.6" "563.5" "480.0" "465.2" "512.7" "486.0" "533.6" "740.9" "570.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4729149100999833326" "False" "High" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "0.000" "False" "46.958" "30" "8" "13" "8" "314" "35.8" "4.74" "44.75" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Macroautophagy" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "6" "0" "0.982" "0.963" "0.950" "0.954" "0.914" "0.949" "0.979" "0.983" "0.962" "930.4" "913.4" "896.3" "884.3" "887.7" "850.0" "883.3" "911.2" "915.0" "895.4" "" "" "" "" "" "" "" "" "" "" "747.3" "659.1" "712.0" "592.5" "613.9" "637.7" "618.4" "665.4" "915.0" "728.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220884936245267041" "False" "High" "IsMasterProtein" "Q8WUA7" "TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2" "0.000" "False" "46.936" "22" "10" "14" "9" "517" "59.1" "5.97" "42.22" "10" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "25771" "ENSG00000054611" "TBC1D22A" "B0QYI2; B0QYI3; B9A6M3; hsa:25771; Q5TE47; Q6ZUH2; Q8WUA7; Q92680; Q9BVD6; Q9UGG0; Q9UGT2; Q9UGU6; Q9UH25; Q9Y4W5" "" "" "0" "1" "1.029" "1.026" "1.136" "1.079" "1.038" "1.021" "1.009" "1.038" "1.079" "762.3" "784.1" "781.9" "865.6" "822.4" "790.9" "778.2" "768.9" "791.0" "822.6" "" "" "" "" "" "" "" "" "" "" "612.2" "565.8" "621.1" "579.9" "568.8" "593.4" "544.9" "561.5" "791.0" "669.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7397667510889778360" "False" "High" "IsMasterProtein" "Q9H4X1" "Regulator of cell cycle RGCC OS=Homo sapiens OX=9606 GN=RGCC PE=1 SV=1" "0.000" "False" "46.896" "45" "4" "7" "4" "137" "14.6" "4.75" "29.31" "4" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15151" "28984" "ENSG00000102760" "RGCC" "hsa:28984; Q6NZ48; Q9H4X1; Q9UL69" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "" "1" "0" "1.083" "1.014" "1.088" "1.050" "1.113" "0.940" "0.998" "1.061" "1.086" "321.7" "348.4" "326.2" "349.9" "337.9" "358.1" "302.3" "321.0" "341.2" "349.3" "" "" "" "" "" "" "" "" "" "" "258.4" "251.4" "259.1" "234.4" "233.7" "268.7" "211.6" "234.4" "341.2" "284.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8372926252788997109" "False" "High" "IsMasterProtein" "Q5JTZ9" "Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1" "0.000" "False" "46.854" "12" "10" "10" "10" "985" "107.3" "6.27" "35.08" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01411, Pf07973" "57505" "ENSG00000124608" "AARS2" "A2RRN5; hsa:57505; Q5JTZ9; Q8N198; Q96D02; Q9ULF0" "Mitochondrial tRNA aminoacylation" "Primary ovarian insufficiency" "2" "0" "1.006" "0.954" "1.074" "1.013" "0.972" "0.963" "0.941" "0.954" "1.008" "788.2" "793.2" "751.9" "846.2" "798.2" "766.4" "759.0" "741.5" "752.0" "794.3" "" "" "" "" "" "" "" "" "" "" "633.1" "572.4" "597.2" "566.9" "552.0" "575.0" "531.4" "541.5" "752.0" "645.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299507636150983864" "False" "High" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "0.000" "False" "46.806" "18" "6" "10" "6" "457" "50.2" "8.31" "38.81" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "" "Iron-sulfur cluster biogenesis" "1" "0" "0.962" "0.957" "0.985" "0.977" "0.960" "0.886" "0.939" "0.954" "0.950" "806.5" "776.1" "771.6" "794.7" "788.2" "774.5" "714.7" "757.5" "769.6" "766.3" "" "" "" "" "" "" "" "" "" "" "647.8" "560.0" "612.9" "532.5" "545.1" "581.1" "500.4" "553.2" "769.6" "623.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1129422898553958470" "False" "High" "IsMasterProtein" "Q86VX9" "Vacuolar fusion protein MON1 homolog A OS=Homo sapiens OX=9606 GN=MON1A PE=1 SV=3" "0.000" "False" "46.804" "15" "7" "8" "7" "652" "72.8" "8.18" "35.14" "7" "transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf19036, Pf19037, Pf19038" "84315" "ENSG00000164077" "MON1A" "B2RDQ1; G5E9N1; hsa:84315; Q86VX9; Q8NAV7; Q9BRF3; X6R3V9" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.064" "0.963" "1.073" "1.078" "1.035" "0.919" "0.963" "1.113" "1.050" "188.9" "201.0" "181.8" "202.7" "203.5" "195.4" "173.5" "182.0" "210.2" "198.3" "" "" "" "" "" "" "" "" "" "" "151.7" "145.1" "144.4" "135.8" "140.8" "146.6" "121.5" "132.9" "210.2" "161.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457086219515973345" "False" "High" "IsMasterProtein" "P61086" "Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3" "0.000" "False" "46.731" "32" "7" "21" "7" "200" "22.4" "5.44" "70.45" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179, Pf00627" "3093" "ENSG00000078140" "UBE2K" "A6NJC1; A8K5Y9; B2RDF8; C9JGP1; hsa:3093; O54806; P27924; P61086; Q16721; Q9CVV9; Q9Y2D3" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Negative regulators of DDX58/IFIH1 signaling" "" "3" "0" "1.062" "0.967" "1.033" "1.073" "0.988" "1.057" "0.971" "1.026" "1.021" "1321.6" "1403.6" "1278.6" "1365.4" "1417.6" "1306.3" "1397.0" "1282.8" "1355.3" "1349.1" "" "" "" "" "" "" "" "" "" "" "1061.5" "1012.8" "1015.6" "914.8" "980.4" "980.1" "978.1" "936.8" "1355.3" "1097.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871053517443562380" "False" "High" "IsMasterProtein" "P57772" "Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4" "0.000" "False" "46.720" "17" "9" "11" "9" "596" "65.3" "8.35" "39.27" "9" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf21131, Pf21208" "60678" "ENSG00000132394; ENSG00000284869" "EEFSEC" "hsa:60678; P57772; Q96HZ6" "Selenocysteine synthesis" "Selenium metabolism and selenoproteins" "2" "0" "1.052" "0.974" "1.161" "1.131" "1.091" "1.218" "1.081" "1.025" "1.143" "493.7" "519.4" "480.8" "573.2" "558.4" "538.6" "601.3" "533.5" "506.0" "564.3" "" "" "" "" "" "" "" "" "" "" "396.6" "374.8" "381.9" "384.0" "386.2" "404.1" "421.0" "389.6" "506.0" "458.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3545967028758689053" "False" "High" "IsMasterProtein" "P36543" "V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1" "0.000" "False" "46.695" "44" "11" "22" "11" "226" "26.1" "8.00" "72.78" "11" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01991" "529" "ENSG00000131100" "ATP6V1E1" "A8MUE4; A8MUN4; hsa:529; P36543" "Insulin receptor recycling; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Transferrin endocytosis and recycling; Ion channel transport" "VEGFA-VEGFR2 signaling; Proximal tubule transport" "7" "0" "1.005" "1.006" "1.049" "1.012" "1.036" "1.040" "0.975" "1.036" "1.014" "2302.1" "2313.6" "2315.9" "2414.5" "2329.3" "2385.9" "2393.8" "2244.3" "2385.6" "2334.7" "" "" "" "" "" "" "" "" "" "" "1849.0" "1669.4" "1839.6" "1617.7" "1610.9" "1790.1" "1676.0" "1639.0" "2385.6" "1898.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507762156530799771" "False" "High" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "0.000" "False" "46.674" "14" "5" "10" "5" "478" "50.7" "9.10" "40.14" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "1.031" "1.015" "1.004" "1.057" "1.032" "0.965" "1.007" "0.950" "0.996" "1255.4" "1294.6" "1274.2" "1260.7" "1327.2" "1295.6" "1211.6" "1264.4" "1192.0" "1249.9" "" "" "" "" "" "" "" "" "" "" "1008.3" "934.2" "1012.2" "844.7" "917.9" "972.0" "848.3" "923.4" "1192.0" "1016.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779852501093026521" "False" "High" "IsMasterProtein" "P15153" "Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1" "0.000" "False" "46.637" "43" "9" "26" "4" "192" "21.4" "7.61" "87.87" "9" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5880" "ENSG00000128340" "RAC2" "hsa:5880; P15153; Q9UDJ4" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; PCP/CE pathway; ROS and RNS production in phagocytes; RHO GTPases Activate NADPH Oxidases" "Integrin-mediated cell adhesion; RalA downstream regulated genes; B cell receptor signaling pathway; Focal adhesion; MAPK signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Macrophage markers; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Insulin signaling; Regulation of actin cytoskeleton; Pathways in cancer; DNA damage response (only ATM dependent)" "24" "5" "1.027" "1.038" "1.042" "1.030" "1.003" "0.990" "0.946" "1.236" "1.080" "1936.7" "1989.8" "2010.3" "2017.4" "1995.6" "1942.8" "1917.3" "1831.4" "2392.8" "2091.8" "" "" "" "" "" "" "" "" "" "" "1555.5" "1435.8" "1596.9" "1351.7" "1380.2" "1457.6" "1342.4" "1337.4" "2392.8" "1701.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7497019614434814723" "False" "High" "IsMasterProtein" "Q9NQH7" "Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1" "0.000" "False" "46.635" "17" "6" "13" "5" "507" "57.0" "6.83" "49.40" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00557, Pf05195" "63929" "ENSG00000196236" "XPNPEP3" "B2R9G1; B7Z790; B7Z7B2; hsa:63929; Q6I9V9; Q8NDA6; Q9BV27; Q9BVH0; Q9NQH7" "" "Ciliary landscape; Ciliopathies" "2" "0" "0.997" "0.959" "0.978" "0.992" "0.970" "0.930" "0.942" "0.969" "0.993" "471.5" "469.9" "452.2" "461.3" "468.0" "457.3" "438.5" "444.2" "456.9" "468.3" "" "" "" "" "" "" "" "" "" "" "378.7" "339.1" "359.2" "309.0" "323.7" "343.1" "307.0" "324.4" "456.9" "380.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1425618486899947959" "False" "High" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "0.000" "False" "46.633" "45" "7" "15" "7" "204" "23.4" "5.49" "46.76" "7" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "1.100" "1.096" "1.061" "1.057" "1.057" "1.068" "0.993" "1.063" "1.068" "716.1" "787.5" "784.7" "759.8" "757.0" "757.1" "764.9" "711.2" "761.5" "764.7" "" "" "" "" "" "" "" "" "" "" "575.1" "568.2" "623.3" "509.0" "523.5" "568.1" "535.5" "519.4" "761.5" "621.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3093573351125982310" "False" "High" "IsMasterProtein" "Q86WJ1" "Chromodomain-helicase-DNA-binding protein 1-like OS=Homo sapiens OX=9606 GN=CHD1L PE=1 SV=3" "0.000" "False" "46.601" "11" "11" "14" "11" "897" "100.9" "6.90" "45.04" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "9557" "ENSG00000131778" "CHD1L" "A5YM64; B4DDE1; B5MDZ7; Q53EZ3; Q5VXX7; Q6DD94; Q6PK83; Q86WJ1; Q86XH3; Q96HF7; Q96SP3; Q9BVJ1; Q9NVV8" "Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "1q21.1 copy number variation syndrome; Nucleotide excision repair in xeroderma pigmentosum" "4" "0" "1.028" "1.010" "1.006" "1.043" "0.979" "0.945" "0.996" "0.971" "1.020" "2087.9" "2147.3" "2108.8" "2099.6" "2176.9" "2045.1" "1972.3" "2078.8" "2028.3" "2130.0" "" "" "" "" "" "" "" "" "" "" "1677.0" "1549.4" "1675.1" "1406.7" "1505.5" "1534.4" "1380.9" "1518.2" "2028.3" "1732.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636260914267966179" "False" "High" "IsMasterProtein" "Q6YP21" "Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1" "0.000" "False" "46.570" "18" "8" "14" "7" "454" "51.4" "8.19" "42.05" "8" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00155" "56267" "ENSG00000137944" "KYAT3" "B3KQ13; hsa:56267; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q6YP21; Q9BVY5" "Tryptophan catabolism" "Tryptophan metabolism" "2" "1" "0.985" "1.046" "0.929" "0.981" "1.015" "0.952" "0.944" "0.936" "0.996" "1014.1" "999.2" "1060.2" "942.5" "994.8" "1028.9" "965.7" "957.0" "949.6" "1010.0" "" "" "" "" "" "" "" "" "" "" "814.5" "721.0" "842.2" "631.5" "688.0" "772.0" "676.1" "698.9" "949.6" "821.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "212659989141045460" "False" "High" "IsMasterProtein" "P78356" "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1" "0.000" "False" "46.521" "21" "8" "16" "4" "416" "47.3" "7.33" "49.92" "8" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf01504" "8396" "ENSG00000276293; ENSG00000277292" "PIP4K2B" "hsa:8396; P78356; Q5U0E8; Q8TBP2" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton; 17q12 copy number variation syndrome" "6" "4" "0.935" "0.958" "0.944" "0.978" "0.925" "1.031" "0.994" "0.986" "0.963" "1814.3" "1696.0" "1737.4" "1711.8" "1773.9" "1677.8" "1869.8" "1804.2" "1788.0" "1746.6" "" "" "" "" "" "" "" "" "" "" "1457.2" "1223.8" "1380.1" "1146.9" "1226.9" "1258.8" "1309.1" "1317.6" "1788.0" "1420.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7569413463716614588" "False" "High" "IsMasterProtein" "Q8N6M0" "Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1" "0.000" "False" "46.509" "31" "9" "16" "8" "293" "33.8" "6.05" "52.33" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf02338" "51633" "ENSG00000155100" "OTUD6B" "A8K6I1; B4DEY0; hsa:51633; Q8N6M0; Q9NTA4; Q9Y387" "" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "1" "0" "1.251" "0.898" "1.300" "1.286" "1.224" "1.226" "1.007" "1.181" "1.092" "446.6" "558.6" "400.8" "580.3" "574.4" "546.4" "547.4" "449.8" "527.4" "487.5" "" "" "" "" "" "" "" "" "" "" "358.7" "403.0" "318.4" "388.8" "397.3" "409.9" "383.3" "328.5" "527.4" "396.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1796554414882976290" "False" "High" "IsMasterProtein" "Q8TCG1" "Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2" "0.000" "False" "46.476" "14" "13" "18" "13" "905" "102.1" "6.23" "51.53" "13" "cell organization and biogenesis;stress response" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf21044" "57650" "ENSG00000163507" "CIP2A" "A1L4J7; B9EGC3; hsa:57650; Q6P4G6; Q8TCG1; Q8WVP8; Q96PI2; Q9H9C6; Q9P204" "" "Netrin-UNC5B signaling pathway" "1" "0" "1.176" "0.974" "1.081" "1.091" "1.105" "1.025" "1.087" "1.120" "1.068" "388.6" "456.9" "378.5" "420.2" "423.8" "429.5" "398.5" "422.5" "435.3" "414.9" "" "" "" "" "" "" "" "" "" "" "312.1" "329.7" "300.7" "281.6" "293.1" "322.2" "279.0" "308.5" "435.3" "337.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5640697701811177027" "False" "High" "IsMasterProtein" "Q8TAG9" "Exocyst complex component 6 OS=Homo sapiens OX=9606 GN=EXOC6 PE=1 SV=3" "0.000" "False" "46.465" "13" "9" "10" "9" "804" "93.7" "6.20" "39.95" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf04091, Pf20651" "54536" "ENSG00000138190" "EXOC6" "E9PHI3; hsa:54536; Q5VXH8; Q8TAG9; Q9NZ24" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Interactions between LOXL4 and oxidative stress pathway; Ciliary landscape" "5" "0" "1.032" "1.020" "1.074" "1.093" "0.983" "1.044" "1.028" "1.065" "1.060" "660.8" "681.9" "673.9" "709.6" "722.0" "649.5" "690.0" "679.3" "703.9" "700.1" "" "" "" "" "" "" "" "" "" "" "530.7" "492.0" "535.3" "475.4" "499.4" "487.3" "483.1" "496.1" "703.9" "569.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4476528208765438767" "False" "High" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "0.000" "False" "46.464" "32" "6" "21" "6" "174" "19.9" "5.72" "72.80" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "6" "0" "0.988" "1.032" "0.943" "0.942" "1.019" "0.914" "0.967" "0.975" "0.940" "1784.5" "1763.0" "1840.9" "1682.9" "1680.5" "1817.7" "1630.2" "1726.0" "1740.0" "1678.2" "" "" "" "" "" "" "" "" "" "" "1433.3" "1272.2" "1462.3" "1127.5" "1162.3" "1363.8" "1141.4" "1260.5" "1740.0" "1364.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4361926129006051556" "False" "High" "IsMasterProtein" "Q9BSH4" "Translational activator of cytochrome c oxidase 1 OS=Homo sapiens OX=9606 GN=TACO1 PE=1 SV=1" "0.000" "False" "46.439" "31" "7" "11" "7" "297" "32.5" "8.13" "46.53" "7" "cell organization and biogenesis;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf01709, Pf20772" "51204" "ENSG00000136463" "TACO1" "B2RD21; hsa:51204; Q8N3N6; Q9BSH4; Q9UI60" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Mitochondrial complex IV assembly" "4" "0" "1.070" "1.062" "1.085" "1.012" "1.019" "1.128" "1.047" "0.988" "1.019" "426.2" "455.9" "452.8" "462.3" "431.5" "434.5" "480.8" "446.3" "421.0" "434.3" "" "" "" "" "" "" "" "" "" "" "342.3" "329.0" "359.7" "309.7" "298.4" "326.0" "336.6" "325.9" "421.0" "353.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3978258356038081382" "False" "High" "IsMasterProtein" "Q13416" "Origin recognition complex subunit 2 OS=Homo sapiens OX=9606 GN=ORC2 PE=1 SV=2" "0.000" "False" "46.429" "20" "8" "9" "8" "577" "65.9" "6.51" "35.76" "8" "DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf04084" "4999" "ENSG00000115942" "ORC2" "hsa:4999; Q13204; Q13416; Q53TX5" "Activation of ATR in response to replication stress; Orc1 removal from chromatin; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "0.989" "1.005" "1.005" "1.087" "1.034" "0.923" "0.912" "0.946" "1.038" "912.4" "902.1" "916.9" "916.6" "991.6" "943.3" "841.8" "832.1" "863.0" "947.1" "" "" "" "" "" "" "" "" "" "" "732.8" "650.9" "728.3" "614.1" "685.8" "707.8" "589.4" "607.7" "863.0" "770.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911764670660096816" "False" "High" "IsMasterProtein" "P08195" "Amino acid transporter heavy chain SLC3A2 OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "0.000" "False" "46.408" "11" "5" "8" "5" "630" "68.0" "5.01" "33.96" "5" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "8" "0" "0.917" "0.912" "0.983" "1.101" "1.075" "1.354" "1.017" "1.180" "1.048" "826.0" "757.1" "752.9" "811.8" "909.2" "888.3" "1118.4" "840.3" "974.8" "865.9" "" "" "" "" "" "" "" "" "" "" "663.4" "546.3" "598.1" "543.9" "628.8" "666.4" "783.1" "613.7" "974.8" "704.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8845776874603627941" "False" "High" "IsMasterProtein" "Q92930" "Ras-related protein Rab-8B OS=Homo sapiens OX=9606 GN=RAB8B PE=1 SV=2" "0.000" "False" "46.379" "41" "8" "19" "2" "207" "23.6" "9.07" "63.21" "8" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "51762" "ENSG00000166128" "RAB8B" "hsa:51762; Q5JPC4; Q92930; Q9P293" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "Ectoderm differentiation; Ectoderm differentiation" "5" "0" "0.662" "0.912" "1.009" "0.985" "0.883" "1.096" "0.900" "0.768" "1.040" "45.6" "30.2" "41.6" "46.0" "44.9" "40.2" "50.0" "41.0" "35.0" "47.4" "" "" "" "" "" "" "" "" "" "" "36.6" "21.8" "33.0" "30.8" "31.0" "30.2" "35.0" "30.0" "35.0" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5155041473924721713" "False" "High" "IsMasterProtein" "P48454" "Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP3CC PE=1 SV=3" "0.000" "False" "46.370" "20" "9" "13" "6" "512" "58.1" "6.98" "45.22" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00149" "5533" "ENSG00000120910" "PPP3CC" "B4DRT5; hsa:5533; P48454; Q9BSS6; Q9H4M5" "DARPP-32 events; Activation of BAD and translocation to mitochondria" "Energy metabolism; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "11" "0" "1.015" "1.022" "1.016" "0.947" "0.977" "0.934" "0.968" "0.926" "0.981" "611.0" "620.4" "624.7" "621.0" "578.4" "597.0" "570.6" "591.6" "565.5" "599.6" "" "" "" "" "" "" "" "" "" "" "490.8" "447.7" "496.3" "416.1" "400.0" "447.9" "399.5" "432.0" "565.5" "487.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3245672403803654152" "False" "High" "IsMasterProtein" "P62263" "Small ribosomal subunit protein uS11 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "0.000" "False" "46.350" "36" "5" "12" "5" "151" "16.3" "10.05" "56.17" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "1.007" "1.077" "1.128" "1.140" "1.104" "1.120" "1.069" "1.101" "1.079" "942.1" "948.3" "1014.7" "1062.3" "1074.4" "1039.6" "1054.8" "1006.7" "1037.5" "1016.0" "" "" "" "" "" "" "" "" "" "" "756.6" "684.2" "806.0" "711.7" "743.0" "780.0" "738.5" "735.2" "1037.5" "826.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1635726356787300158" "False" "High" "IsMasterProtein" "Q7LDG7" "RAS guanyl-releasing protein 2 OS=Homo sapiens OX=9606 GN=RASGRP2 PE=1 SV=1" "0.000" "False" "46.345" "17" "9" "10" "9" "609" "69.2" "7.80" "35.04" "9" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00130, Pf00617, Pf00618, Pf13202" "10235" "ENSG00000068831" "RASGRP2" "A6NDC7; hsa:10235; O00538; Q7LDG7; Q9UL65" "Integrin signaling; Rap1 signalling; FCERI mediated NF-kB activation; Effects of PIP2 hydrolysis" "MAPK signaling pathway; Chemokine signaling pathway; Ras signaling" "7" "0" "0.951" "0.943" "1.000" "0.951" "0.905" "0.949" "1.010" "0.926" "1.005" "732.2" "696.2" "690.4" "732.3" "696.2" "662.8" "694.9" "739.7" "678.2" "735.8" "" "" "" "" "" "" "" "" "" "" "588.1" "502.3" "548.4" "490.7" "481.5" "497.3" "486.5" "540.2" "678.2" "598.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361850666082059512" "False" "High" "IsMasterProtein" "P54252" "Ataxin-3 OS=Homo sapiens OX=9606 GN=ATXN3 PE=1 SV=5" "0.000" "False" "46.311" "28" "7" "10" "7" "361" "41.2" "4.78" "35.87" "7" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02099, Pf02809, Pf16619" "4287" "ENSG00000066427" "ATXN3" "A7LFZ5; D6RDL9; E9PB63; hsa:4287; O15284; O15285; O15286; P54252; Q8N189; Q96TC3; Q96TC4; Q9H3N0" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Josephin domain DUBs" "HDAC6 interactions in the central nervous system" "3" "0" "0.985" "0.948" "1.005" "0.975" "0.934" "0.922" "0.957" "0.943" "0.979" "815.3" "803.3" "773.2" "819.3" "795.0" "761.7" "751.6" "780.1" "768.8" "798.3" "" "" "" "" "" "" "" "" "" "" "654.8" "579.6" "614.2" "548.9" "549.8" "571.5" "526.2" "569.7" "768.8" "649.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3259776130493618651" "False" "High" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "0.000" "False" "46.303" "16" "11" "13" "11" "645" "73.5" "8.02" "43.45" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.019" "1.035" "1.056" "1.013" "1.009" "0.965" "0.969" "0.935" "0.987" "1067.4" "1087.6" "1104.5" "1127.5" "1081.3" "1077.0" "1030.1" "1034.4" "997.6" "1053.1" "" "" "" "" "" "" "" "" "" "" "857.3" "784.8" "877.3" "755.4" "747.9" "808.1" "721.2" "755.4" "997.6" "856.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6460139479284416051" "False" "High" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "0.000" "False" "46.294" "12" "8" "10" "8" "904" "98.6" "8.40" "35.17" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "1.010" "1.044" "1.184" "1.178" "1.095" "1.172" "1.076" "1.078" "1.102" "429.3" "433.7" "448.0" "508.4" "505.6" "469.9" "503.2" "462.0" "462.6" "473.0" "" "" "" "" "" "" "" "" "" "" "344.8" "313.0" "355.9" "340.6" "349.7" "352.6" "352.3" "337.4" "462.6" "384.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7849372490440627698" "False" "High" "IsMasterProtein" "Q96P16" "Regulation of nuclear pre-mRNA domain-containing protein 1A OS=Homo sapiens OX=9606 GN=RPRD1A PE=1 SV=1" "0.000" "False" "46.280" "35" "7" "10" "7" "312" "35.7" "7.55" "38.24" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "55197" "ENSG00000141425" "RPRD1A" "A8KA42; B2RBA3; hsa:55197; Q7Z5G8; Q96FY9; Q96P16; Q9NVL4" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.987" "0.923" "1.049" "1.122" "0.964" "1.009" "0.982" "1.017" "1.006" "672.0" "663.4" "620.1" "705.2" "753.7" "647.7" "678.2" "659.7" "683.6" "675.7" "" "" "" "" "" "" "" "" "" "" "539.8" "478.7" "492.5" "472.5" "521.3" "485.9" "474.9" "481.8" "683.6" "549.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5039007955841066877" "False" "High" "IsMasterProtein" "Q15397" "Pumilio homolog 3 OS=Homo sapiens OX=9606 GN=PUM3 PE=1 SV=3" "0.000" "False" "46.265" "16" "11" "13" "11" "648" "73.5" "9.64" "44.33" "11" "other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf08144" "9933" "ENSG00000080608" "PUM3" "A8K804; hsa:9933; Q15397; Q547G7; Q5SZY9; Q6IB47; Q96B27; Q96L78; Q96L79; Q96L80" "" "" "0" "0" "1.167" "1.138" "1.127" "1.258" "1.169" "1.169" "1.106" "1.091" "1.163" "562.9" "657.1" "640.4" "634.6" "708.1" "658.2" "658.0" "622.7" "614.1" "654.8" "" "" "" "" "" "" "" "" "" "" "452.1" "474.2" "508.7" "425.2" "489.7" "493.8" "460.7" "454.8" "614.1" "532.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3533689105478908948" "False" "High" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "0.000" "False" "46.246" "59" "6" "19" "6" "112" "12.5" "4.78" "66.26" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "22" "0" "1.191" "1.140" "1.047" "0.975" "1.119" "0.994" "1.032" "1.056" "1.094" "1360.3" "1619.5" "1550.3" "1424.4" "1325.7" "1521.9" "1351.4" "1403.7" "1436.0" "1488.7" "" "" "" "" "" "" "" "" "" "" "1092.5" "1168.6" "1231.5" "954.4" "916.8" "1141.9" "946.2" "1025.1" "1436.0" "1210.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5796509123597455273" "False" "High" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "0.000" "False" "46.219" "27" "6" "12" "4" "356" "39.4" "7.20" "45.38" "6" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "1.285" "0.977" "1.229" "1.350" "1.301" "1.305" "1.047" "1.296" "1.167" "236.8" "304.2" "231.5" "291.0" "319.6" "308.0" "308.9" "248.0" "306.9" "276.5" "" "" "" "" "" "" "" "" "" "" "190.2" "219.5" "183.9" "195.0" "221.1" "231.1" "216.3" "181.1" "306.9" "224.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9165342661713370894" "False" "High" "IsMasterProtein" "Q969U7" "Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1" "0.000" "False" "46.216" "34" "10" "18" "10" "264" "29.4" "6.98" "48.98" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf09754" "56984" "ENSG00000128789" "PSMG2" "B0YJB3; hsa:56984; Q6IAH4; Q969U7; Q9NRV1; V9GYH7" "" "" "0" "0" "1.021" "1.031" "0.961" "0.996" "1.015" "0.962" "1.022" "0.992" "0.984" "1642.8" "1677.9" "1694.0" "1578.9" "1635.6" "1666.6" "1579.7" "1678.2" "1629.7" "1616.0" "" "" "" "" "" "" "" "" "" "" "1319.5" "1210.7" "1345.6" "1057.9" "1131.2" "1250.4" "1106.0" "1225.6" "1629.7" "1314.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257899417113298170" "False" "High" "IsMasterProtein" "P78316" "Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3" "0.000" "False" "46.150" "11" "8" "10" "8" "857" "97.6" "7.58" "38.39" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04147" "8602" "ENSG00000087269" "NOP14" "D3DVR6; hsa:8602; P78316; Q7LGI5; Q7Z6K0; Q8TBR6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.044" "1.030" "1.096" "1.026" "1.001" "1.039" "1.122" "1.094" "1.052" "1243.2" "1298.3" "1280.7" "1363.1" "1275.2" "1243.8" "1291.8" "1395.4" "1360.6" "1307.5" "" "" "" "" "" "" "" "" "" "" "998.5" "936.8" "1017.3" "913.3" "882.0" "933.2" "904.5" "1019.1" "1360.6" "1063.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4770714879888361237" "False" "High" "IsMasterProtein" "Q5GLZ8" "Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1" "0.000" "False" "46.145" "11" "11" "13" "11" "1057" "118.5" "6.19" "42.06" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632" "26091" "ENSG00000148634" "HERC4" "hsa:26091; Q5GC98; Q5GC99; Q5GCA0; Q5GLZ8; Q8IXP9; Q9HCH9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.030" "1.008" "1.068" "1.070" "1.076" "1.016" "1.025" "1.033" "1.057" "963.8" "993.1" "971.9" "1029.6" "1031.4" "1037.1" "979.7" "988.3" "995.7" "1018.7" "" "" "" "" "" "" "" "" "" "" "774.1" "716.6" "772.0" "689.8" "713.3" "778.1" "685.9" "721.8" "995.7" "828.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6665492664209257681" "False" "High" "IsMasterProtein" "Q6P1Q9" "tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3" "0.000" "False" "46.127" "16" "5" "8" "5" "378" "43.4" "5.86" "32.15" "5" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf08242" "55798" "ENSG00000165055" "METTL2B" "B4DZ68; hsa:55798; Q0IJ54; Q3B7J1; Q6P1Q9" "" "" "0" "0" "0.959" "1.001" "1.016" "0.997" "0.979" "1.031" "1.039" "1.001" "1.058" "500.8" "480.1" "501.3" "508.6" "499.5" "490.1" "516.5" "520.6" "501.2" "530.1" "" "" "" "" "" "" "" "" "" "" "402.2" "346.4" "398.2" "340.8" "345.5" "367.7" "361.6" "380.2" "501.2" "431.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782870004774892945" "False" "High" "IsMasterProtein" "Q15796" "Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1" "0.000" "False" "46.039" "16" "7" "20" "4" "467" "52.3" "6.58" "54.02" "7" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4087" "ENSG00000175387" "SMAD2" "hsa:4087; Q15796" "Ub-specific processing proteases; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; Transcriptional regulation of pluripotent stem cells; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "Cell cycle; AGE/RAGE pathway; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; LDLRAD4 and what we know about it; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; GDNF signaling; Inflammatory bowel disease signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling" "49" "1" "0.996" "1.049" "1.035" "0.969" "1.035" "1.002" "0.986" "1.055" "1.060" "677.5" "674.9" "710.6" "701.3" "656.8" "701.1" "678.8" "668.3" "715.0" "718.0" "" "" "" "" "" "" "" "" "" "" "544.2" "487.0" "564.4" "469.9" "454.3" "526.0" "475.2" "488.1" "715.0" "583.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6706450895826488783" "False" "High" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "0.000" "False" "46.005" "27" "6" "14" "6" "264" "29.6" "6.15" "48.38" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Formation of TC-NER Pre-Incision Complex; Neddylation; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "Ciliary landscape" "5" "0" "1.035" "0.996" "1.025" "1.025" "0.986" "0.945" "0.909" "1.086" "0.984" "823.5" "852.2" "819.9" "843.7" "844.0" "811.8" "778.5" "748.2" "894.6" "810.2" "" "" "" "" "" "" "" "" "" "" "661.4" "614.9" "651.3" "565.3" "583.7" "609.0" "545.1" "546.4" "894.6" "658.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-569299239056590327" "False" "High" "IsMasterProtein" "Q9Y4F9" "Rho family-interacting cell polarization regulator 2 OS=Homo sapiens OX=9606 GN=RIPOR2 PE=1 SV=4" "0.000" "False" "45.994" "7" "7" "8" "7" "1068" "118.4" "5.41" "29.50" "7" "cell adhesion;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf15903" "9750" "ENSG00000111913" "RIPOR2" "A6NHP2; hsa:9750; Q13529; Q5VV37; Q5VV38; Q9BQ28; Q9Y4F9" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "1.041" "0.991" "0.978" "1.033" "1.004" "1.004" "1.181" "1.087" "0.997" "726.8" "756.9" "720.2" "711.1" "750.5" "730.0" "729.9" "858.3" "790.0" "724.6" "" "" "" "" "" "" "" "" "" "" "583.8" "546.2" "572.1" "476.4" "519.1" "547.7" "511.0" "626.8" "790.0" "589.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7261913870359179685" "False" "High" "IsMasterProtein" "O75165" "DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5" "0.000" "False" "45.955" "7" "14" "15" "14" "2243" "254.3" "6.74" "35.73" "14" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00226, Pf14237, Pf19432" "23317" "ENSG00000138246" "DNAJC13" "hsa:23317; O75165; Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9" "Neutrophil degranulation" "" "1" "0" "1.006" "0.941" "1.014" "1.059" "1.029" "1.042" "0.981" "1.034" "1.014" "598.9" "602.5" "563.6" "607.3" "634.5" "616.0" "623.9" "587.4" "619.5" "607.3" "" "" "" "" "" "" "" "" "" "" "481.0" "434.7" "447.7" "406.9" "438.9" "462.2" "436.8" "428.9" "619.5" "493.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021992825547666354" "False" "High" "IsMasterProtein" "Q8TDB6" "E3 ubiquitin-protein ligase DTX3L OS=Homo sapiens OX=9606 GN=DTX3L PE=1 SV=1" "0.000" "False" "45.920" "13" "9" "10" "9" "740" "83.5" "8.06" "35.17" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf13923, Pf18102, Pf21717, Pf21718" "151636" "ENSG00000163840" "DTX3L" "B3KWH6; Q53ZZ3; Q5MJP7; Q8TDB6" "Antigen processing: Ubiquitination & Proteasome degradation" "Notch signaling" "2" "0" "1.073" "1.052" "1.055" "1.040" "1.067" "1.055" "1.096" "1.184" "1.090" "752.3" "807.3" "791.1" "794.0" "782.1" "802.4" "793.7" "824.1" "890.9" "820.2" "" "" "" "" "" "" "" "" "" "" "604.2" "582.5" "628.4" "532.0" "540.9" "602.0" "555.7" "601.8" "890.9" "667.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6062730820723703914" "False" "High" "IsMasterProtein" "P82094" "TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2" "0.000" "False" "45.844" "10" "10" "12" "10" "1093" "122.8" "4.92" "39.28" "10" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf12325, Pf12329" "7110" "ENSG00000144747" "TMF1" "B7ZLJ2; hsa:7110; P82094; Q17R87; Q59GK0" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.975" "1.037" "1.050" "1.099" "1.127" "1.079" "1.178" "1.069" "1.131" "1848.1" "1802.1" "1915.6" "1939.6" "2030.4" "2083.2" "1994.4" "2176.6" "1976.2" "2090.8" "" "" "" "" "" "" "" "" "" "" "1484.4" "1300.3" "1521.6" "1299.6" "1404.2" "1563.0" "1396.4" "1589.6" "1976.2" "1700.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575206036117319314" "False" "High" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "0.000" "False" "45.841" "14" "8" "12" "7" "721" "82.1" "6.95" "37.35" "8" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; Q68CV3; Q9NXH5; Q9Y608" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.941" "1.010" "1.150" "1.105" "1.173" "1.204" "1.212" "1.183" "1.148" "633.0" "595.7" "639.6" "727.8" "699.6" "742.7" "762.1" "767.1" "748.8" "726.7" "" "" "" "" "" "" "" "" "" "" "508.4" "429.8" "508.1" "487.6" "483.9" "557.2" "533.6" "560.2" "748.8" "591.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585340363182511889" "False" "High" "IsMasterProtein" "Q9HBU6" "Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1" "0.000" "False" "45.825" "20" "9" "15" "9" "452" "50.9" "6.54" "48.81" "9" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "55500" "ENSG00000139163" "ETNK1" "G5E969; hsa:55500; Q9HBU6" "Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "5" "0" "1.071" "1.029" "1.097" "1.074" "1.049" "1.119" "1.074" "1.084" "1.054" "1266.2" "1356.4" "1302.4" "1388.6" "1360.5" "1327.7" "1416.8" "1360.2" "1372.0" "1334.7" "" "" "" "" "" "" "" "" "" "" "1017.0" "978.8" "1034.5" "930.4" "940.9" "996.1" "991.9" "993.4" "1372.0" "1085.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9188891296985920952" "False" "High" "IsMasterProtein" "P31483" "Cytotoxic granule associated RNA binding protein TIA1 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "0.000" "False" "45.798" "25" "7" "14" "5" "386" "42.9" "7.74" "52.56" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "FGFR2 alternative splicing" "" "1" "0" "1.004" "0.996" "1.094" "1.150" "1.013" "1.167" "1.083" "1.004" "1.034" "614.6" "617.1" "612.0" "672.5" "706.5" "622.6" "716.9" "665.4" "616.8" "635.2" "" "" "" "" "" "" "" "" "" "" "493.6" "445.2" "486.1" "450.6" "488.6" "467.2" "501.9" "485.9" "616.8" "516.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7670404762929313903" "False" "High" "IsMasterProtein" "Q9BYW2" "Histone-lysine N-methyltransferase SETD2 OS=Homo sapiens OX=9606 GN=SETD2 PE=1 SV=3" "0.000" "False" "45.768" "5" "12" "13" "12" "2564" "287.4" "6.14" "37.91" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00856, Pf08236, Pf17907" "29072" "ENSG00000181555" "SETD2" "hsa:29072; O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0; Q9BYW2; Q9C0D1; Q9H696; Q9NZW9" "PKMTs methylate histone lysines" "Histone modifications; Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Pleural mesothelioma" "8" "0" "1.062" "1.052" "1.091" "1.071" "1.015" "0.986" "1.103" "1.082" "1.051" "1003.1" "1064.8" "1055.4" "1094.8" "1074.1" "1018.4" "989.0" "1106.2" "1085.7" "1054.7" "" "" "" "" "" "" "" "" "" "" "805.7" "768.4" "838.4" "733.5" "742.8" "764.1" "692.5" "807.8" "1085.7" "857.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4173136633731686100" "False" "High" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "0.000" "False" "45.767" "12" "10" "12" "10" "882" "97.5" "6.21" "43.44" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "Interferon gamma signaling; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; p53 transcriptional gene network; Acute myeloid leukemia; DNA damage response" "13" "0" "1.031" "0.988" "1.110" "1.005" "0.986" "1.114" "0.927" "0.978" "1.039" "837.1" "863.2" "827.2" "929.5" "841.0" "825.2" "932.3" "775.6" "818.7" "870.1" "" "" "" "" "" "" "" "" "" "" "672.4" "622.9" "657.1" "622.8" "581.6" "619.2" "652.7" "566.4" "818.7" "707.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750059555873910244" "False" "High" "IsMasterProtein" "Q96KB5" "Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3" "0.000" "False" "45.757" "38" "12" "18" "12" "322" "36.1" "5.12" "56.34" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "55872" "ENSG00000168078" "PBK" "B4DX68; D3DST2; hsa:55872; Q96KB5; Q9NPD9; Q9NYL7; Q9NZK6" "" "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling" "2" "0" "0.993" "0.950" "0.939" "0.919" "0.926" "0.921" "0.934" "0.924" "0.985" "1084.1" "1076.5" "1029.5" "1017.9" "996.3" "1003.5" "998.6" "1012.2" "1002.1" "1067.5" "" "" "" "" "" "" "" "" "" "" "870.8" "776.8" "817.7" "682.0" "689.0" "752.9" "699.2" "739.2" "1002.1" "868.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-162623303281005711" "False" "High" "IsMasterProtein" "P49917" "DNA ligase 4 OS=Homo sapiens OX=9606 GN=LIG4 PE=1 SV=2" "0.000" "False" "45.746" "14" "10" "13" "10" "911" "103.9" "7.96" "42.88" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01068, Pf04675, Pf04679, Pf11411" "3981" "ENSG00000174405" "LIG4" "hsa:3981; P49917; Q8IY66; Q8TEU5" "Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "Non-homologous end joining; Male infertility; DNA repair pathways, full network" "5" "0" "1.051" "0.907" "1.045" "0.997" "1.114" "1.052" "0.996" "0.951" "1.014" "444.3" "467.1" "402.8" "464.3" "443.1" "494.9" "467.2" "442.6" "422.7" "450.5" "" "" "" "" "" "" "" "" "" "" "356.9" "337.1" "320.0" "311.1" "306.4" "371.3" "327.1" "323.2" "422.7" "366.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838480320139969571" "False" "High" "IsMasterProtein" "Q13951" "Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2" "0.000" "False" "45.738" "35" "7" "13" "7" "182" "21.5" "6.60" "52.95" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02312" "865" "ENSG00000067955" "CBFB" "A8K347; hsa:865; Q13124; Q13951; Q9HCT2" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; RUNX2 regulates osteoblast differentiation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Estrogen-dependent gene expression; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Transcriptional regulation of granulopoiesis; RUNX2 regulates genes involved in cell migration; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX2 regulates chondrocyte maturation; RUNX3 Regulates Immune Response and Cell Migration; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX3 regulates RUNX1-mediated transcription" "Dual hijack model of Vif in HIV infection; Hijack of ubiquitination by SARS-CoV-2" "27" "0" "1.042" "1.125" "1.089" "1.112" "1.050" "1.044" "1.113" "1.109" "1.078" "1221.3" "1272.8" "1374.4" "1330.6" "1357.9" "1282.0" "1275.5" "1359.7" "1354.3" "1317.2" "" "" "" "" "" "" "" "" "" "" "981.0" "918.4" "1091.8" "891.5" "939.2" "961.9" "893.1" "993.0" "1354.3" "1071.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857218708684993243" "False" "High" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "0.000" "False" "45.662" "37" "9" "13" "9" "318" "35.2" "8.94" "39.57" "9" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Neutrophil degranulation; Pentose phosphate pathway" "Pentose phosphate pathway in senescent cells" "3" "0" "0.998" "0.970" "1.162" "1.123" "0.977" "1.101" "1.006" "0.994" "1.046" "628.2" "627.1" "609.5" "730.0" "705.2" "613.5" "691.6" "631.7" "624.7" "657.1" "" "" "" "" "" "" "" "" "" "" "504.6" "452.5" "484.1" "489.1" "487.7" "460.3" "484.3" "461.4" "624.7" "534.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020319621841403457" "False" "High" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "0.000" "False" "45.560" "42" "7" "20" "7" "180" "19.6" "6.02" "56.67" "7" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "" "3" "0" "0.987" "0.963" "0.985" "0.995" "0.903" "0.918" "0.968" "0.898" "0.881" "915.7" "904.1" "881.9" "902.4" "910.8" "826.7" "840.3" "886.1" "822.1" "807.2" "" "" "" "" "" "" "" "" "" "" "735.5" "652.4" "700.6" "604.6" "629.9" "620.2" "588.3" "647.1" "822.1" "656.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4097484419734302186" "False" "High" "IsMasterProtein" "Q9UBL3" "Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1" "0.000" "False" "45.551" "16" "10" "13" "10" "628" "68.7" "5.69" "37.07" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622, Pf21198, Pf21257" "9070" "ENSG00000129691" "ASH2L" "A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Deactivation of the beta-catenin transactivating complex; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Kleefstra syndrome" "7" "0" "0.942" "0.992" "0.915" "0.939" "0.965" "0.917" "0.945" "0.982" "0.989" "1527.2" "1439.0" "1515.5" "1397.1" "1433.9" "1474.3" "1401.0" "1442.9" "1500.3" "1510.7" "" "" "" "" "" "" "" "" "" "" "1226.6" "1038.4" "1203.8" "936.0" "991.7" "1106.2" "980.9" "1053.8" "1500.3" "1228.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "258971474423548673" "False" "High" "IsMasterProtein" "Q14746" "Conserved oligomeric Golgi complex subunit 2 OS=Homo sapiens OX=9606 GN=COG2 PE=1 SV=1" "0.000" "False" "45.545" "16" "10" "11" "10" "738" "83.2" "6.62" "37.03" "10" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "other molecular function" "Pf06148, Pf12022" "22796" "ENSG00000135775" "COG2" "hsa:22796; Q14746; Q86U99" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "1.057" "0.967" "1.082" "0.975" "0.919" "0.907" "0.954" "0.957" "0.979" "414.6" "438.1" "400.9" "448.5" "404.1" "380.9" "376.1" "395.6" "396.6" "405.8" "" "" "" "" "" "" "" "" "" "" "333.0" "316.1" "318.4" "300.5" "279.5" "285.8" "263.3" "288.9" "396.6" "330.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583280322088088435" "False" "High" "IsMasterProtein" "Q9NPF4" "tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1" "0.000" "False" "45.492" "30" "8" "15" "8" "335" "36.4" "6.35" "38.20" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00814" "55644" "ENSG00000092094; ENSG00000291794" "OSGEP" "hsa:55644; Q6IAC3; Q9NPF4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.026" "1.005" "1.010" "0.982" "0.994" "0.945" "0.953" "0.971" "0.980" "965.4" "990.9" "970.2" "974.9" "948.3" "959.5" "911.9" "919.9" "937.3" "945.7" "" "" "" "" "" "" "" "" "" "" "775.4" "715.0" "770.7" "653.2" "655.8" "719.9" "638.5" "671.8" "937.3" "769.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2210442272290705579" "False" "High" "IsMasterProtein" "P09493" "Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=2" "0.000" "False" "45.439" "24" "9" "23" "1" "284" "32.7" "4.74" "65.09" "9" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00261" "7168" "ENSG00000140416" "TPM1" "B7Z5T7; D9YZV2; D9YZV3; D9YZV8; hsa:7168; P09493; P09494; P10469; Q6DV89; Q6DV90; Q7Z6L8; Q86W64; Q96IK2; Q9UCI1; Q9UCI2; Q9UCY9; Q9Y427" "Smooth Muscle Contraction; Striated Muscle Contraction" "Vitamin D receptor pathway; Striated muscle contraction pathway; Cell lineage map for neuronal differentiation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077095867447308247" "False" "High" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "0.000" "False" "45.410" "24" "8" "10" "8" "421" "46.1" "9.99" "37.44" "8" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "0.887" "1.099" "1.074" "1.126" "1.082" "1.209" "1.078" "1.022" "1.043" "610.8" "541.8" "671.5" "656.0" "687.8" "661.0" "738.6" "658.4" "624.1" "637.0" "" "" "" "" "" "" "" "" "" "" "490.6" "390.9" "533.4" "439.5" "475.7" "495.9" "517.1" "480.8" "624.1" "518.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6429762109324514714" "False" "High" "IsMasterProtein" "O75607" "Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3" "0.000" "False" "45.395" "47" "5" "9" "5" "178" "19.3" "4.63" "33.02" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03066" "10360" "ENSG00000107833" "NPM3" "hsa:10360; O75607; Q9UNY6" "" "" "0" "0" "1.081" "1.085" "1.096" "1.117" "1.146" "1.087" "1.144" "1.017" "1.141" "327.1" "353.6" "355.0" "358.4" "365.3" "374.8" "355.5" "374.4" "332.7" "373.1" "" "" "" "" "" "" "" "" "" "" "262.8" "255.2" "282.0" "240.2" "252.6" "281.2" "248.9" "273.4" "332.7" "303.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1961832364316848105" "False" "High" "IsMasterProtein" "Q9NVM4" "Protein arginine N-methyltransferase 7 OS=Homo sapiens OX=9606 GN=PRMT7 PE=1 SV=1" "0.000" "False" "45.380" "19" "9" "10" "9" "692" "78.4" "5.57" "34.96" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf06325" "54496" "ENSG00000132600" "PRMT7" "B3KPR0; B3KUG9; B4E379; hsa:54496; Q96PV5; Q9H9L0; Q9NVM4" "RMTs methylate histone arginines" "Nitric oxide metabolism in cystic fibrosis" "2" "0" "1.012" "1.030" "1.084" "1.090" "1.048" "1.066" "1.078" "1.101" "0.972" "414.5" "419.4" "426.8" "449.5" "451.8" "434.5" "441.8" "446.9" "456.3" "403.0" "" "" "" "" "" "" "" "" "" "" "332.9" "302.7" "339.0" "301.2" "312.5" "326.0" "309.4" "326.4" "456.3" "327.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4473457085686512926" "False" "High" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "0.000" "False" "45.352" "17" "8" "14" "8" "407" "42.1" "5.07" "48.43" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Ub-specific processing proteases; UCH proteinases" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "4" "0" "0.984" "0.996" "0.973" "0.936" "0.984" "0.908" "1.017" "0.934" "0.945" "1081.7" "1064.6" "1077.3" "1052.8" "1012.0" "1064.7" "981.7" "1100.3" "1010.8" "1022.3" "" "" "" "" "" "" "" "" "" "" "868.8" "768.2" "855.7" "705.4" "699.9" "798.8" "687.3" "803.5" "1010.8" "831.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5840066189523461680" "False" "High" "IsMasterProtein" "P22694" "cAMP-dependent protein kinase catalytic subunit beta OS=Homo sapiens OX=9606 GN=PRKACB PE=1 SV=2" "0.000" "False" "45.338" "22" "7" "10" "2" "351" "40.6" "8.78" "39.57" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5567" "ENSG00000142875" "PRKACB" "B1APG4; B4DKB0; B4E2Q1; hsa:5567; P22694; Q14VH1; Q59GC0; Q5BNE9; Q5BNF0; Q5BNF1; Q5BNF2; Q5BNF3; Q5CZ92; Q5T1K3; Q7Z3M1; Q8IYR5; Q8IZQ0; Q96B09" "FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "AMP-activated protein kinase signaling; Dopamine metabolism; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Chemokine signaling pathway; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "47" "0" "1.084" "1.032" "1.042" "1.020" "1.142" "1.166" "1.073" "1.065" "1.091" "153.7" "166.6" "158.6" "160.2" "156.9" "175.6" "179.3" "165.0" "163.7" "167.8" "" "" "" "" "" "" "" "" "" "" "123.5" "120.2" "126.0" "107.3" "108.5" "131.8" "125.5" "120.5" "163.7" "136.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8914003618785624230" "False" "High" "IsMasterProtein" "O75934" "Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1" "0.000" "False" "45.332" "35" "7" "13" "7" "225" "26.1" "5.66" "44.90" "7" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "" "Pf05700" "10286" "ENSG00000116752" "BCAS2" "hsa:10286; O75934; Q6FGS0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.002" "1.049" "1.015" "0.982" "1.012" "1.004" "1.070" "1.062" "1.043" "1295.7" "1298.8" "1359.1" "1315.6" "1272.3" "1311.2" "1301.4" "1386.3" "1375.6" "1351.2" "" "" "" "" "" "" "" "" "" "" "1040.7" "937.2" "1079.6" "881.4" "879.9" "983.8" "911.2" "1012.4" "1375.6" "1098.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4687575668731336676" "False" "High" "IsMasterProtein" "Q6UX04" "Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1" "0.000" "False" "45.254" "25" "9" "10" "9" "472" "53.8" "5.80" "36.21" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00160" "10283" "ENSG00000153015" "CWC27" "hsa:10283; O60529; O60530; Q6UX04; Q96EM3" "mRNA Splicing - Major Pathway" "" "1" "0" "0.997" "1.069" "1.088" "1.078" "1.079" "1.143" "1.109" "1.053" "1.031" "611.2" "609.4" "653.0" "665.0" "659.0" "659.5" "698.3" "677.6" "643.5" "629.9" "" "" "" "" "" "" "" "" "" "" "490.9" "439.7" "518.7" "445.6" "455.8" "494.8" "488.9" "494.8" "643.5" "512.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519635040323081051" "False" "High" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "0.000" "False" "45.229" "29" "5" "13" "4" "191" "21.2" "6.55" "52.99" "5" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; MAPK6/MAPK4 signaling; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; RHOU GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; VEGFA-VEGFR2 Pathway; Myogenesis; Factors involved in megakaryocyte development and platelet production; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "63" "0" "0.966" "0.956" "0.931" "1.077" "1.031" "1.116" "1.061" "1.136" "0.973" "1585.6" "1532.3" "1515.7" "1475.9" "1707.5" "1634.1" "1768.8" "1682.3" "1801.4" "1543.0" "" "" "" "" "" "" "" "" "" "" "1273.5" "1105.7" "1204.0" "988.8" "1180.9" "1226.0" "1238.4" "1228.6" "1801.4" "1254.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8332128719972757989" "False" "High" "IsMasterProtein" "Q8IY67" "Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1" "0.000" "False" "45.226" "12" "6" "11" "6" "606" "63.8" "8.48" "38.33" "6" "" "nucleus;other cell component" "" "Pf00076" "125950" "" "RAVER1" "A6NMU4; hsa:125950; Q8IY60; Q8IY67; Q8TF24" "" "" "0" "0" "0.995" "1.014" "1.029" "1.031" "0.919" "0.990" "1.008" "1.016" "0.990" "393.3" "391.4" "398.7" "404.9" "405.7" "361.3" "389.6" "396.5" "399.6" "389.4" "" "" "" "" "" "" "" "" "" "" "315.9" "282.5" "316.7" "271.3" "280.6" "271.1" "272.8" "289.6" "399.6" "316.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874885037648560876" "False" "High" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "0.000" "False" "45.224" "61" "13" "21" "13" "148" "16.4" "9.95" "60.07" "13" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "1.044" "1.053" "1.109" "1.074" "1.132" "1.069" "1.097" "1.062" "1.019" "1583.7" "1654.0" "1667.8" "1755.8" "1701.3" "1792.9" "1692.4" "1736.7" "1682.2" "1614.1" "" "" "" "" "" "" "" "" "" "" "1272.0" "1193.5" "1324.8" "1176.4" "1176.6" "1345.2" "1184.9" "1268.3" "1682.2" "1312.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4764020307768204184" "False" "High" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "0.000" "False" "45.183" "38" "6" "27" "6" "193" "21.8" "6.10" "92.22" "6" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; VEGFA-VEGFR2 Pathway; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; GNAQ pathways in port-wine stain; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "71" "0" "0.976" "1.001" "0.939" "0.951" "0.958" "0.940" "0.943" "0.948" "0.933" "2992.4" "2919.6" "2994.0" "2810.1" "2845.6" "2867.9" "2812.4" "2822.2" "2835.6" "2791.0" "" "" "" "" "" "" "" "" "" "" "2403.4" "2106.7" "2378.2" "1882.8" "1968.1" "2151.8" "1969.1" "2061.0" "2835.6" "2269.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705673583208632788" "False" "High" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "0.000" "False" "45.168" "31" "7" "15" "7" "234" "25.5" "8.51" "41.64" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Pyrimidine salvage; G1/S-Specific Transcription" "Fluoropyrimidine activity; Pyrimidine metabolism" "4" "0" "0.933" "1.034" "0.924" "0.923" "0.897" "1.354" "1.507" "1.410" "1.042" "810.2" "756.0" "838.1" "748.6" "747.5" "727.1" "1097.1" "1220.8" "1142.5" "844.2" "" "" "" "" "" "" "" "" "" "" "650.7" "545.5" "665.7" "501.5" "517.0" "545.5" "768.1" "891.6" "1142.5" "686.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421392599925785436" "False" "High" "IsMasterProtein" "Q9HD15" "Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=2" "0.000" "False" "45.133" "39" "8" "13" "8" "224" "24.4" "7.50" "46.47" "8" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07304" "10011" "ENSG00000213523" "SRA1" "hsa:10011; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14; Q9HD15" "" "" "0" "0" "1.043" "1.006" "1.139" "0.992" "1.030" "1.052" "1.043" "1.118" "1.058" "1115.1" "1163.5" "1121.6" "1270.2" "1106.5" "1148.8" "1172.7" "1163.3" "1247.2" "1179.4" "" "" "" "" "" "" "" "" "" "" "895.7" "839.6" "890.9" "851.0" "765.3" "861.9" "821.0" "849.6" "1247.2" "959.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7829507115951982075" "False" "High" "IsMasterProtein" "P19387" "DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens OX=9606 GN=POLR2C PE=1 SV=2" "0.000" "False" "45.132" "27" "5" "10" "5" "275" "31.4" "4.92" "34.67" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "5432" "ENSG00000102978" "POLR2C" "hsa:5432; O15161; P19387" "Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Inhibition of DNA recombination at telomere; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "Pyrimidine metabolism; Eukaryotic transcription initiation; Primary ovarian insufficiency" "44" "0" "0.956" "0.950" "0.950" "0.944" "0.978" "0.902" "0.933" "1.017" "0.957" "823.3" "787.2" "782.1" "782.3" "777.4" "804.9" "742.7" "767.8" "837.0" "788.1" "" "" "" "" "" "" "" "" "" "" "661.3" "568.1" "621.3" "524.1" "537.7" "603.9" "520.0" "560.7" "837.0" "640.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3574208382527803870" "False" "High" "IsMasterProtein" "Q9Y2X7" "ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2" "0.000" "False" "45.096" "17" "12" "16" "10" "761" "84.3" "6.80" "52.32" "12" "transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf12796, Pf16559" "28964" "ENSG00000108262" "GIT1" "B4DGU9; B4DSV3; hsa:28964; Q86SS0; Q9BRJ4; Q9Y2X7" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs" "CAMKK2 pathway; Regulation of actin cytoskeleton" "12" "0" "1.040" "1.038" "1.100" "0.964" "1.042" "1.004" "1.045" "1.120" "1.036" "659.9" "686.4" "684.9" "725.8" "636.2" "687.9" "662.7" "689.8" "738.9" "683.8" "" "" "" "" "" "" "" "" "" "" "530.0" "495.3" "544.1" "486.3" "440.0" "516.2" "464.0" "503.7" "738.9" "556.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1714630333721311506" "False" "High" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "0.000" "False" "45.034" "27" "10" "11" "10" "386" "43.5" "8.19" "42.16" "10" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "0.949" "0.938" "0.939" "0.984" "0.969" "0.959" "0.956" "0.931" "0.960" "1790.7" "1699.6" "1679.2" "1680.7" "1762.5" "1735.6" "1718.0" "1711.2" "1667.0" "1718.4" "" "" "" "" "" "" "" "" "" "" "1438.3" "1226.4" "1333.8" "1126.1" "1219.0" "1302.2" "1202.9" "1249.7" "1667.0" "1397.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538784976841218653" "False" "High" "IsMasterProtein" "Q8N5C6" "S1 RNA-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SRBD1 PE=1 SV=2" "0.000" "False" "45.023" "8" "8" "9" "8" "995" "111.7" "8.72" "33.92" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf00575, Pf09371, Pf12836, Pf16921, Pf17674" "55133" "ENSG00000068784" "SRBD1" "hsa:55133; Q53T56; Q8N5C6; Q96TA4; Q9NW11" "" "" "0" "0" "1.035" "1.021" "1.008" "1.056" "0.965" "0.959" "0.978" "0.934" "0.959" "473.8" "490.2" "483.8" "477.4" "500.1" "457.4" "454.2" "463.2" "442.7" "454.2" "" "" "" "" "" "" "" "" "" "" "380.6" "353.7" "384.3" "319.8" "345.9" "343.2" "318.0" "338.3" "442.7" "369.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991992927110115551" "False" "High" "IsMasterProtein" "Q99504" "Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3" "0.000" "False" "44.980" "10" "8" "12" "8" "573" "62.6" "5.21" "41.89" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00702" "2140" "ENSG00000158161" "EYA3" "A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "" "1" "0" "0.972" "1.006" "0.998" "0.977" "0.975" "0.962" "1.033" "0.995" "1.033" "1090.1" "1059.8" "1096.3" "1088.4" "1064.8" "1063.0" "1049.0" "1126.0" "1084.7" "1126.4" "" "" "" "" "" "" "" "" "" "" "875.5" "764.7" "870.8" "729.2" "736.4" "797.6" "734.4" "822.3" "1084.7" "916.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877506006391296740" "False" "High" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "0.000" "False" "44.971" "31" "7" "15" "7" "239" "25.3" "4.92" "45.88" "7" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.935" "0.985" "0.965" "0.988" "1.005" "0.965" "0.953" "0.937" "0.968" "1192.1" "1115.1" "1174.0" "1150.3" "1177.9" "1197.7" "1150.9" "1136.3" "1117.2" "1153.8" "" "" "" "" "" "" "" "" "" "" "957.5" "804.6" "932.5" "770.7" "814.6" "898.6" "805.8" "829.9" "1117.2" "938.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1695167521897825927" "False" "High" "IsMasterProtein" "P53609" "Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2" "0.000" "False" "44.963" "20" "7" "17" "7" "377" "42.3" "6.83" "48.97" "7" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00432" "5229" "ENSG00000164219" "PGGT1B" "hsa:5229; P53609; Q5MJP9" "" "" "0" "0" "1.002" "1.013" "0.963" "1.044" "1.027" "1.028" "1.034" "0.992" "1.055" "1169.3" "1171.4" "1184.6" "1126.5" "1221.3" "1200.3" "1202.0" "1208.9" "1159.4" "1233.9" "" "" "" "" "" "" "" "" "" "" "939.2" "845.3" "940.9" "754.7" "844.7" "900.6" "841.6" "882.9" "1159.4" "1003.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6883226900925947322" "False" "High" "IsMasterProtein" "Q9BW83" "Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1" "0.000" "False" "44.953" "51" "9" "13" "9" "186" "20.5" "5.41" "43.53" "9" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "11020" "ENSG00000100360" "IFT27" "hsa:11020; O60897; Q9BW83" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; GDNF/RET signaling axis; Alstrom syndrome; Bardet-Biedl syndrome" "8" "0" "0.958" "0.980" "0.988" "1.068" "0.996" "0.987" "1.005" "0.987" "1.040" "1151.7" "1103.7" "1128.7" "1138.3" "1229.5" "1146.5" "1136.2" "1157.9" "1137.2" "1198.1" "" "" "" "" "" "" "" "" "" "" "925.0" "796.4" "896.6" "762.7" "850.3" "860.2" "795.5" "845.6" "1137.2" "974.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1785172786280045072" "False" "High" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "0.000" "False" "44.913" "30" "6" "14" "6" "217" "25.1" "6.15" "44.02" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "33" "0" "1.025" "0.977" "1.052" "1.129" "1.122" "1.153" "1.135" "1.047" "1.071" "1108.6" "1136.4" "1082.5" "1166.7" "1251.3" "1243.6" "1278.5" "1258.4" "1160.6" "1186.9" "" "" "" "" "" "" "" "" "" "" "890.4" "820.0" "859.9" "781.7" "865.4" "933.1" "895.1" "919.0" "1160.6" "965.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5858537743821975597" "False" "High" "IsMasterProtein" "O75843" "AP-1 complex subunit gamma-like 2 OS=Homo sapiens OX=9606 GN=AP1G2 PE=1 SV=1" "0.000" "False" "44.850" "17" "13" "16" "12" "785" "87.1" "6.55" "43.82" "13" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf02883" "8906" "ENSG00000213983" "AP1G2" "D3DS51; hsa:8906; O75504; O75843" "Lysosome Vesicle Biogenesis" "" "1" "0" "1.137" "1.033" "1.102" "1.139" "1.042" "1.055" "1.121" "0.982" "1.091" "327.5" "372.4" "338.3" "360.9" "373.0" "341.3" "345.4" "367.0" "321.6" "357.3" "" "" "" "" "" "" "" "" "" "" "263.0" "268.7" "268.7" "241.8" "258.0" "256.1" "241.9" "268.0" "321.6" "290.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9109513475254745228" "False" "High" "IsMasterProtein" "Q9UBD5" "Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1" "0.000" "False" "44.773" "14" "10" "15" "10" "711" "82.2" "7.61" "44.82" "10" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07034, Pf18137, Pf19675" "23595" "ENSG00000135336" "ORC3" "A2A2T5; B4E025; hsa:23595; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UBD5; Q9UG44; Q9UNT6" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "1.033" "1.052" "1.003" "0.987" "0.986" "0.889" "0.914" "0.923" "0.973" "1289.2" "1331.2" "1356.2" "1292.8" "1272.0" "1271.0" "1146.1" "1178.3" "1189.5" "1254.9" "" "" "" "" "" "" "" "" "" "" "1035.5" "960.5" "1077.3" "866.2" "879.7" "953.6" "802.4" "860.5" "1189.5" "1020.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260092317082084293" "False" "High" "IsMasterProtein" "Q13362" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP2R5C PE=1 SV=3" "0.000" "False" "44.681" "17" "8" "15" "5" "524" "61.0" "6.87" "48.22" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5527" "ENSG00000078304" "PPP2R5C" "B4DYJ8; B5BUA5; F5GWP3; hsa:5527; Q13362; Q14391; Q15060; Q15174; Q6ZN33" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "29" "0" "0.976" "1.093" "1.171" "1.131" "1.110" "1.095" "1.011" "1.064" "1.064" "324.2" "316.3" "354.2" "379.8" "366.7" "359.9" "354.9" "327.7" "345.1" "344.8" "" "" "" "" "" "" "" "" "" "" "260.4" "228.2" "281.4" "254.4" "253.6" "270.0" "248.5" "239.3" "345.1" "280.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2971731893176673056" "False" "High" "IsMasterProtein" "O15305" "Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1" "0.000" "False" "44.653" "37" "9" "12" "8" "246" "28.1" "6.77" "40.58" "9" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03332" "5373" "ENSG00000140650" "PMM2" "A8K672; B7Z6R0; D3DUF3; hsa:5373; O15305" "Defective PMM2 causes PMM2-CDG; Synthesis of GDP-mannose" "Nephrotic syndrome; N-glycan biosynthesis; Primary ovarian insufficiency" "5" "1" "0.936" "0.962" "0.917" "0.928" "0.993" "0.915" "0.968" "0.925" "0.958" "1445.7" "1352.8" "1390.3" "1325.7" "1342.2" "1435.8" "1323.0" "1398.8" "1337.8" "1384.5" "" "" "" "" "" "" "" "" "" "" "1161.2" "976.2" "1104.4" "888.2" "928.3" "1077.2" "926.3" "1021.5" "1337.8" "1125.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910081975799465505" "False" "High" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "0.000" "False" "44.628" "13" "10" "12" "10" "1029" "118.2" "8.47" "34.33" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "mRNA Splicing - Major Pathway" "" "1" "0" "1.050" "1.108" "1.010" "1.018" "0.981" "0.947" "0.989" "1.027" "1.058" "501.6" "526.6" "556.0" "506.7" "510.8" "492.1" "474.9" "496.0" "515.4" "530.6" "" "" "" "" "" "" "" "" "" "" "402.9" "380.0" "441.7" "339.5" "353.3" "369.2" "332.5" "362.2" "515.4" "431.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6183242122487478565" "False" "High" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "0.000" "False" "44.610" "54" "5" "11" "5" "164" "17.8" "5.03" "42.38" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "1.024" "1.017" "1.097" "1.046" "1.051" "1.058" "1.009" "1.136" "1.030" "940.5" "963.4" "956.1" "1032.1" "984.1" "988.0" "995.5" "948.9" "1068.7" "969.2" "" "" "" "" "" "" "" "" "" "" "755.4" "695.2" "759.5" "691.5" "680.6" "741.3" "697.0" "693.0" "1068.7" "788.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824521577804774203" "False" "High" "IsMasterProtein" "Q53GS9" "Ubiquitin carboxyl-terminal hydrolase 39 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "0.000" "False" "44.599" "15" "8" "13" "8" "565" "65.3" "8.91" "40.38" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "mRNA Splicing - Major Pathway" "" "1" "0" "0.947" "0.960" "0.914" "1.014" "0.929" "1.011" "0.985" "0.900" "1.021" "1142.7" "1081.8" "1096.8" "1045.0" "1158.4" "1061.1" "1155.4" "1126.0" "1028.1" "1166.5" "" "" "" "" "" "" "" "" "" "" "917.8" "780.6" "871.2" "700.1" "801.1" "796.1" "808.9" "822.3" "1028.1" "948.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100137965290358990" "False" "High" "IsMasterProtein" "Q9UJW0" "Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1" "0.000" "False" "44.540" "23" "7" "10" "7" "460" "52.3" "7.34" "37.58" "7" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05502" "51164" "ENSG00000132912" "DCTN4" "B3KWW0; D3DQH0; E5RGT5; hsa:51164; Q8TAN8; Q9UJW0" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "Vasopressin-regulated water reabsorption" "5" "0" "1.001" "1.023" "0.814" "0.906" "1.122" "0.840" "1.032" "1.063" "1.007" "778.3" "778.9" "796.1" "633.6" "705.0" "872.9" "653.6" "803.3" "826.9" "783.3" "" "" "" "" "" "" "" "" "" "" "625.1" "562.0" "632.4" "424.5" "487.6" "655.0" "457.6" "586.7" "826.9" "637.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1240749293216846131" "False" "High" "IsMasterProtein" "Q13526" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1" "0.000" "False" "44.539" "37" "4" "9" "4" "163" "18.2" "8.82" "37.98" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00397, Pf00639" "5300" "ENSG00000127445" "PIN1" "A8K4V9; hsa:5300; Q13526; Q53X75" "Regulation of TP53 Activity through Phosphorylation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation; RHO GTPases Activate NADPH Oxidases" "Novel intracellular components of RIG-I-like receptor pathway" "6" "0" "1.023" "1.054" "1.049" "1.210" "1.069" "1.205" "1.119" "1.089" "1.117" "961.2" "983.5" "1013.6" "1008.7" "1162.7" "1027.8" "1157.9" "1075.4" "1046.5" "1073.5" "" "" "" "" "" "" "" "" "" "" "772.1" "709.6" "805.1" "675.8" "804.1" "771.1" "810.7" "785.4" "1046.5" "873.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225336690214534054" "False" "High" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "0.000" "False" "44.534" "54" "6" "20" "5" "121" "13.4" "7.24" "60.17" "6" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "MASTL Facilitates Mitotic Progression" "" "1" "2" "1.054" "1.045" "0.996" "1.113" "1.204" "1.049" "1.093" "1.119" "1.156" "842.8" "888.1" "880.6" "839.3" "937.9" "1014.9" "883.9" "920.9" "943.3" "974.2" "" "" "" "" "" "" "" "" "" "" "677.0" "640.8" "699.5" "562.3" "648.7" "761.4" "618.9" "672.6" "943.3" "792.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939496649029224586" "False" "High" "IsMasterProtein" "P51812" "Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1" "0.000" "False" "44.420" "14" "12" "15" "4" "740" "83.7" "6.89" "47.65" "12" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6197" "ENSG00000177189" "RPS6KA3" "B2R9V4; hsa:6197; P51812; Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7" "Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Thermogenesis; EGF/EGFR signaling pathway; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6610589870849209696" "False" "High" "IsMasterProtein" "Q9NZ63" "Splicing factor C9orf78 OS=Homo sapiens OX=9606 GN=C9orf78 PE=1 SV=1" "0.000" "False" "44.406" "34" "9" "17" "9" "289" "33.7" "6.74" "59.30" "9" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07052" "51759" "ENSG00000136819" "C9orf78" "B3KPX8; Q8WVU6; Q9NT39; Q9NZ63" "mRNA Splicing - Major Pathway" "" "1" "0" "1.045" "1.060" "1.011" "0.964" "1.030" "0.951" "1.009" "1.010" "0.993" "1976.9" "2066.1" "2094.9" "1999.3" "1904.8" "2035.6" "1880.6" "1994.0" "1995.9" "1963.3" "" "" "" "" "" "" "" "" "" "" "1587.8" "1490.8" "1664.1" "1339.5" "1317.4" "1527.3" "1316.7" "1456.2" "1995.9" "1596.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4228584982071455131" "False" "High" "IsMasterProtein" "Q92769" "Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2" "0.000" "False" "44.382" "27" "12" "19" "6" "488" "55.3" "5.91" "47.90" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "3066" "ENSG00000196591" "HDAC2" "B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769" "Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels" "Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in progeria; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway" "30" "0" "1.054" "1.093" "1.083" "1.072" "1.032" "1.041" "1.210" "1.204" "1.087" "351.5" "370.3" "384.3" "380.5" "376.8" "362.9" "365.9" "425.3" "423.2" "381.9" "" "" "" "" "" "" "" "" "" "" "282.3" "267.2" "305.3" "254.9" "260.6" "272.2" "256.2" "310.6" "423.2" "310.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3304952133381549298" "False" "High" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "0.000" "False" "44.377" "36" "9" "11" "9" "292" "33.5" "4.84" "38.60" "9" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "0" "1.097" "1.084" "1.043" "1.008" "1.073" "1.066" "1.111" "1.060" "1.092" "1371.8" "1505.1" "1487.5" "1431.0" "1382.3" "1471.6" "1462.4" "1523.8" "1454.5" "1497.5" "" "" "" "" "" "" "" "" "" "" "1101.8" "1086.1" "1181.6" "958.8" "956.0" "1104.1" "1023.9" "1112.8" "1454.5" "1217.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7212172965787635527" "False" "High" "IsMasterProtein" "Q15031" "Leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2" "0.000" "False" "44.306" "12" "12" "15" "12" "903" "101.9" "8.22" "51.99" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00133, Pf08264, Pf13603" "23395" "ENSG00000011376" "LARS2" "hsa:23395; Q15031" "Mitochondrial tRNA aminoacylation" "Amino acid metabolism; IL-18 signaling pathway; Primary ovarian insufficiency" "4" "0" "1.012" "1.008" "1.023" "1.048" "1.047" "0.967" "1.008" "0.994" "1.024" "1104.6" "1118.1" "1113.1" "1130.1" "1157.1" "1156.4" "1067.6" "1113.9" "1098.1" "1131.3" "" "" "" "" "" "" "" "" "" "" "887.2" "806.8" "884.2" "757.1" "800.3" "867.6" "747.5" "813.5" "1098.1" "920.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "523405854747225660" "False" "High" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "0.000" "False" "44.294" "16" "8" "11" "7" "522" "58.7" "6.33" "35.92" "8" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "0.953" "0.962" "0.941" "0.954" "0.962" "1.004" "1.035" "1.060" "1.007" "784.0" "747.0" "753.8" "737.8" "747.6" "754.2" "787.3" "811.0" "831.3" "789.5" "" "" "" "" "" "" "" "" "" "" "629.7" "539.0" "598.8" "494.3" "517.1" "565.9" "551.2" "592.3" "831.3" "642.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1760362922626917016" "False" "High" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "0.000" "False" "44.291" "33" "4" "18" "4" "172" "18.6" "9.51" "47.08" "4" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "1.078" "1.045" "1.121" "1.130" "1.055" "1.095" "1.066" "1.010" "1.046" "965.9" "1041.3" "1008.9" "1082.9" "1091.2" "1018.8" "1057.5" "1029.4" "975.8" "1010.4" "" "" "" "" "" "" "" "" "" "" "775.8" "751.3" "801.4" "725.5" "754.7" "764.4" "740.4" "751.8" "975.8" "821.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945611468628581935" "False" "High" "IsMasterProtein" "Q96I25" "Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1" "0.000" "False" "44.274" "23" "8" "12" "7" "401" "44.9" "5.97" "43.82" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf01585" "84991" "ENSG00000134453" "RBM17" "hsa:84991; Q96GY6; Q96I25" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.002" "1.018" "0.969" "0.982" "0.976" "0.954" "1.057" "0.983" "1.013" "742.2" "743.9" "755.2" "718.9" "728.6" "724.2" "708.1" "784.8" "729.8" "751.9" "" "" "" "" "" "" "" "" "" "" "596.1" "536.8" "599.9" "481.6" "503.9" "543.3" "495.8" "573.2" "729.8" "611.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5259121706082363690" "False" "High" "IsMasterProtein" "Q6NS38" "DNA oxidative demethylase ALKBH2 OS=Homo sapiens OX=9606 GN=ALKBH2 PE=1 SV=1" "0.000" "False" "44.248" "26" "5" "9" "5" "261" "29.3" "9.66" "35.11" "5" "DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13532" "121642" "ENSG00000189046" "ALKBH2" "A4PET2; hsa:121642; Q5XLE3; Q6NS38" "ALKBH2 mediated reversal of alkylation damage" "Direct reversal repair" "2" "0" "1.081" "0.991" "0.991" "0.949" "0.974" "0.822" "0.795" "0.841" "0.979" "661.4" "715.0" "655.6" "655.7" "627.6" "644.4" "543.7" "525.5" "556.0" "647.8" "" "" "" "" "" "" "" "" "" "" "531.2" "515.9" "520.8" "439.3" "434.0" "483.5" "380.6" "383.8" "556.0" "526.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1708640290626267049" "False" "High" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "0.000" "False" "44.203" "33" "6" "15" "6" "136" "14.6" "10.04" "57.83" "6" "other biological processes" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "" "2" "0" "1.024" "1.143" "0.923" "0.994" "0.991" "0.984" "1.041" "0.966" "0.937" "2721.9" "2787.3" "3111.7" "2513.1" "2706.0" "2697.8" "2679.3" "2833.3" "2628.9" "2549.7" "" "" "" "" "" "" "" "" "" "" "2186.2" "2011.2" "2471.7" "1683.8" "1871.5" "2024.1" "1875.9" "2069.2" "2628.9" "2073.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625852785660981987" "False" "High" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "0.000" "False" "44.174" "44" "8" "13" "8" "192" "22.0" "5.73" "39.19" "8" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "Q15126; Q5TZW9" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "1.024" "0.977" "0.909" "0.966" "0.966" "0.891" "0.970" "1.054" "0.987" "575.6" "589.6" "562.3" "523.3" "556.0" "555.9" "512.7" "558.2" "606.9" "567.9" "" "" "" "" "" "" "" "" "" "" "462.3" "425.4" "446.7" "350.6" "384.5" "417.1" "358.9" "407.7" "606.9" "461.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8603846715658809849" "False" "High" "IsMasterProtein" "Q14807" "Kinesin-like protein KIF22 OS=Homo sapiens OX=9606 GN=KIF22 PE=1 SV=5" "0.000" "False" "44.161" "13" "8" "9" "8" "665" "73.2" "9.45" "33.73" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225, Pf12836" "3835" "ENSG00000079616" "KIF22" "B2R5M0; B7Z265; hsa:3835; O60845; O94814; Q14807; Q53F58; Q9BT46" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "16p11.2 proximal deletion syndrome" "4" "0" "1.003" "1.024" "1.091" "1.126" "1.106" "1.170" "1.125" "1.116" "1.093" "835.3" "837.4" "855.0" "911.4" "940.5" "923.7" "977.6" "939.8" "931.8" "912.7" "" "" "" "" "" "" "" "" "" "" "670.9" "604.3" "679.2" "610.7" "650.5" "693.0" "684.5" "686.3" "931.8" "742.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773607396615155691" "False" "High" "IsMasterProtein" "Q16774" "Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2" "0.000" "False" "44.149" "53" "8" "11" "8" "197" "21.7" "6.55" "31.95" "8" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00625" "2987" "ENSG00000143774" "GUK1" "B1ANH1; hsa:2987; Q16774" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME" "" "2" "0" "1.082" "1.065" "1.043" "1.030" "1.028" "1.040" "1.040" "1.035" "1.040" "789.8" "854.4" "841.3" "823.8" "813.3" "812.3" "821.1" "821.2" "817.4" "821.4" "" "" "" "" "" "" "" "" "" "" "634.4" "616.5" "668.3" "552.0" "562.5" "609.4" "574.9" "599.7" "817.4" "668.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2529735565303520700" "False" "High" "IsMasterProtein" "Q9BQS8" "FYVE and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FYCO1 PE=1 SV=3" "0.000" "False" "44.144" "8" "10" "10" "10" "1478" "166.9" "4.92" "31.08" "10" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "79443" "ENSG00000163820" "FYCO1" "B7ZKT7; hsa:79443; Q3MJE6; Q86T41; Q86TB1; Q8TEF9; Q96IV5; Q9BQS8; Q9H8P9" "" "Clock-controlled autophagy in bone metabolism" "1" "0" "1.109" "1.087" "1.102" "1.077" "1.084" "1.055" "1.060" "1.107" "1.103" "628.6" "696.9" "683.0" "692.7" "677.0" "681.3" "663.1" "666.1" "695.8" "693.2" "" "" "" "" "" "" "" "" "" "" "504.9" "502.9" "542.5" "464.1" "468.2" "511.2" "464.3" "486.5" "695.8" "563.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321429417116917544" "False" "High" "IsMasterProtein" "P07339" "Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1" "0.000" "False" "44.138" "25" "9" "12" "9" "412" "44.5" "6.54" "42.32" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026, Pf07966" "1509" "ENSG00000117984" "CTSD" "hsa:1509; P07339; Q6IB57" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins" "Prolactin signaling pathway; 8p23.1 copy number variation syndrome" "8" "0" "0.974" "0.976" "1.081" "1.086" "1.052" "1.048" "1.026" "1.041" "1.068" "867.4" "844.6" "846.8" "938.0" "942.3" "912.6" "909.0" "890.2" "902.8" "926.5" "" "" "" "" "" "" "" "" "" "" "696.7" "609.5" "672.7" "628.5" "651.7" "684.7" "636.4" "650.1" "902.8" "753.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530850700352278513" "False" "High" "IsMasterProtein" "Q15700" "Disks large homolog 2 OS=Homo sapiens OX=9606 GN=DLG2 PE=1 SV=3" "0.000" "False" "44.110" "8" "6" "11" "4" "870" "97.5" "6.47" "34.93" "6" "cell adhesion;cell-cell signaling;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600, Pf10608" "1740" "ENSG00000150672" "DLG2" "B7WNY8; F8W9V6; hsa:1740; Q15700; Q59G57; Q5H9Q4; Q68CQ8; Q6ZTA8" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation" "Disruption of postsynaptic signaling by CNV; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "10" "0" "1.033" "1.033" "1.034" "1.008" "0.971" "1.002" "0.912" "0.957" "1.053" "393.6" "406.5" "406.7" "407.0" "396.6" "382.1" "394.3" "359.0" "376.6" "414.4" "" "" "" "" "" "" "" "" "" "" "316.1" "293.3" "323.1" "272.7" "274.3" "286.7" "276.1" "262.2" "376.6" "337.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711402174933544761" "False" "High" "IsMasterProtein" "Q8NG31" "Kinetochore scaffold 1 OS=Homo sapiens OX=9606 GN=KNL1 PE=1 SV=3" "0.000" "False" "44.101" "5" "12" "12" "12" "2342" "265.2" "5.47" "35.61" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf18210, Pf19221" "57082" "ENSG00000137812" "KNL1" "hsa:57082; Q8NG31; Q8NHE1; Q8WXA6; Q9HCK2; Q9NR92" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "" "7" "0" "1.057" "0.981" "1.029" "1.032" "1.008" "1.042" "1.103" "1.129" "1.066" "833.1" "880.5" "817.2" "857.2" "859.9" "839.5" "867.9" "918.9" "940.5" "888.3" "" "" "" "" "" "" "" "" "" "" "669.1" "635.3" "649.2" "574.4" "594.7" "629.9" "607.7" "671.0" "940.5" "722.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3824226989303919527" "False" "High" "IsMasterProtein" "Q68EM7" "Rho GTPase-activating protein 17 OS=Homo sapiens OX=9606 GN=ARHGAP17 PE=1 SV=1" "0.000" "False" "44.093" "10" "8" "14" "8" "881" "95.4" "7.62" "41.50" "8" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "55114" "ENSG00000140750; ENSG00000288353" "ARHGAP17" "A8K6M6; hsa:55114; Q68EM7; Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "" "6" "0" "0.952" "0.930" "0.995" "0.957" "0.941" "0.868" "0.899" "0.943" "0.937" "1103.9" "1050.4" "1027.2" "1098.9" "1056.7" "1038.5" "958.6" "992.1" "1040.8" "1033.8" "" "" "" "" "" "" "" "" "" "" "886.6" "757.9" "815.9" "736.2" "730.8" "779.2" "671.2" "724.5" "1040.8" "840.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100821946699504428" "False" "High" "IsMasterProtein" "Q5QNW6" "Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3" "0.000" "False" "44.052" "53" "8" "37" "0" "126" "13.9" "10.32" "120.87" "8" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "440689" "ENSG00000203814" "H2BC18" "A8K0U9; B4DLA9; hsa:440689; Q5QNW6" "Ub-specific processing proteases; HCMV Late Events; HCMV Early Events; HDACs deacetylate histones; HATs acetylate histones" "" "5" "2" "1.081" "1.242" "1.000" "1.171" "1.317" "0.999" "1.235" "1.187" "1.151" "736.9" "796.5" "915.2" "737.2" "862.6" "970.2" "736.2" "910.2" "875.1" "847.9" "" "" "" "" "" "" "" "" "" "" "591.9" "574.7" "727.0" "493.9" "596.6" "727.9" "515.5" "664.7" "875.1" "689.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "947873724462567429" "False" "High" "IsMasterProtein" "Q9UNQ2" "Dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1" "0.000" "False" "43.970" "26" "9" "11" "9" "313" "35.2" "9.99" "37.28" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00398" "27292" "ENSG00000086189" "DIMT1" "O76025; Q9BU77; Q9UES1; Q9UNQ2" "rRNA modification in the nucleus and cytosol" "" "1" "0" "1.039" "1.020" "1.086" "1.100" "1.040" "1.035" "1.057" "0.993" "1.013" "559.2" "580.9" "570.6" "607.4" "614.8" "581.5" "578.5" "591.2" "555.4" "566.3" "" "" "" "" "" "" "" "" "" "" "449.1" "419.1" "453.2" "407.0" "425.2" "436.3" "405.0" "431.7" "555.4" "460.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8717511238945883438" "False" "High" "IsMasterProtein" "Q12769" "Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3" "0.000" "False" "43.951" "9" "10" "10" "10" "1436" "162.0" "5.50" "35.26" "10" "other metabolic processes;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf11715" "23279" "ENSG00000030066" "NUP160" "B4DYE8; B4E2J9; hsa:23279; Q08AD3; Q12769; Q7Z5X6; Q96GB3; Q9H660" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "35" "0" "1.038" "1.078" "1.042" "0.967" "1.001" "0.861" "1.115" "1.056" "1.021" "670.7" "696.2" "723.1" "699.0" "648.3" "671.7" "577.3" "747.6" "708.6" "684.6" "" "" "" "" "" "" "" "" "" "" "538.7" "502.4" "574.4" "468.3" "448.4" "504.0" "404.2" "546.0" "708.6" "556.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "365000218227711707" "False" "High" "IsMasterProtein" "Q99880" "Histone H2B type 1-L OS=Homo sapiens OX=9606 GN=H2BC13 PE=1 SV=3" "0.000" "False" "43.916" "53" "8" "35" "1" "126" "13.9" "10.32" "115.73" "8" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8340" "ENSG00000185130" "H2BC13" "B2R5A3; hsa:8340; Q52LW9; Q99880" "Senescence-Associated Secretory Phenotype (SASP); Transcriptional regulation of granulopoiesis; Ub-specific processing proteases; Meiotic synapsis; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; Nonhomologous End-Joining (NHEJ); RUNX1 regulates transcription of genes involved in differentiation of HSCs; Pre-NOTCH Transcription and Translation; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; HATs acetylate histones; PRC2 methylates histones and DNA; E3 ubiquitin ligases ubiquitinate target proteins; Amyloid fiber formation; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Replacement of protamines by nucleosomes in the male pronucleus" "" "45" "0" "0.900" "1.055" "1.193" "1.120" "1.166" "1.077" "1.064" "1.203" "1.018" "79.5" "71.6" "83.9" "94.9" "89.0" "92.7" "85.6" "84.6" "95.7" "80.9" "" "" "" "" "" "" "" "" "" "" "63.9" "51.6" "66.6" "63.6" "61.6" "69.6" "59.9" "61.8" "95.7" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369435830510499583" "False" "High" "IsMasterProtein" "Q9GZP4" "PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1" "0.000" "False" "43.864" "60" "12" "17" "12" "211" "24.2" "5.74" "52.95" "12" "other biological processes" "other cell component" "" "Pf06201" "57095" "ENSG00000057757" "PITHD1" "B2R7J4; hsa:57095; Q5QPN6; Q5QPN7; Q9GZP4; Q9NRI8" "" "" "0" "0" "1.069" "1.003" "1.001" "1.024" "1.007" "0.954" "0.955" "1.027" "0.952" "787.6" "842.1" "789.6" "788.2" "806.9" "793.4" "751.0" "752.4" "808.6" "750.0" "" "" "" "" "" "" "" "" "" "" "632.6" "607.6" "627.2" "528.1" "558.0" "595.3" "525.8" "549.5" "808.6" "609.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1130211750852848646" "False" "High" "IsMasterProtein" "Q13404" "Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2" "0.000" "False" "43.822" "57" "8" "22" "3" "147" "16.5" "7.93" "59.40" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00179" "387522; 7335" "ENSG00000244687" "UBE2V1" "E1P629; hsa:387522; hsa:7335; Q13403; Q13404; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aggrephagy; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "19" "5" "1.045" "1.045" "1.005" "1.020" "1.079" "0.993" "0.938" "0.991" "1.020" "2112.0" "2207.3" "2206.4" "2123.5" "2153.7" "2278.4" "2097.8" "1982.1" "2093.1" "2154.2" "" "" "" "" "" "" "" "" "" "" "1696.3" "1592.7" "1752.6" "1422.8" "1489.5" "1709.5" "1468.8" "1447.5" "2093.1" "1751.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2021642276248058836" "False" "High" "IsMasterProtein" "Q8TD30" "Alanine aminotransferase 2 OS=Homo sapiens OX=9606 GN=GPT2 PE=1 SV=1" "0.000" "False" "43.800" "21" "9" "9" "9" "523" "57.9" "7.71" "32.55" "9" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00155" "84706" "ENSG00000166123" "GPT2" "hsa:84706; Q8N9E2; Q8TD30" "" "Amino acid metabolism; Amino acid metabolism pathway excerpt: histidine catabolism extension" "2" "0" "0.990" "0.979" "1.017" "1.022" "0.945" "1.010" "1.069" "1.079" "1.004" "922.5" "913.2" "903.5" "938.1" "943.1" "872.1" "931.8" "986.1" "995.8" "926.4" "" "" "" "" "" "" "" "" "" "" "740.9" "659.0" "717.7" "628.5" "652.3" "654.3" "652.4" "720.2" "995.8" "753.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105726009165371323" "False" "High" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "0.000" "False" "43.800" "23" "7" "15" "7" "350" "37.9" "8.73" "49.50" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "4" "0" "0.917" "0.985" "0.994" "0.946" "0.902" "0.993" "1.060" "0.962" "0.935" "1046.0" "958.7" "1029.8" "1039.8" "990.1" "943.0" "1038.7" "1108.8" "1006.7" "978.2" "" "" "" "" "" "" "" "" "" "" "840.2" "691.8" "818.0" "696.6" "684.7" "707.5" "727.3" "809.8" "1006.7" "795.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8487408262660345487" "False" "High" "IsMasterProtein" "P11388" "DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3" "0.000" "False" "43.744" "6" "9" "14" "8" "1531" "174.3" "8.72" "44.99" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7153" "ENSG00000131747" "TOP2A" "B2RTS1; hsa:7153; P11388; Q71UN1; Q71UQ5; Q9HB24; Q9HB25; Q9HB26; Q9UP44; Q9UQP9" "SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex" "Gastric cancer network 1; Gastric cancer network 2; Retinoblastoma gene in cancer" "5" "1" "1.024" "0.992" "1.037" "1.000" "1.007" "1.089" "1.060" "1.054" "1.052" "1388.8" "1422.9" "1377.1" "1440.6" "1389.4" "1397.9" "1512.5" "1472.6" "1463.5" "1460.5" "" "" "" "" "" "" "" "" "" "" "1115.5" "1026.7" "1093.9" "965.2" "960.9" "1048.8" "1059.0" "1075.4" "1463.5" "1187.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2170038667873591835" "False" "High" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "0.000" "False" "43.743" "5" "11" "11" "11" "2357" "251.7" "5.80" "38.90" "11" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "COPII-mediated vesicle transport" "" "1" "0" "0.977" "1.049" "1.080" "1.093" "1.128" "1.173" "1.138" "1.130" "1.095" "1023.8" "1000.6" "1073.7" "1105.4" "1119.1" "1154.8" "1201.3" "1165.0" "1156.7" "1120.7" "" "" "" "" "" "" "" "" "" "" "822.3" "722.0" "852.8" "740.6" "774.0" "866.4" "841.1" "850.8" "1156.7" "911.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7401329575601911727" "False" "High" "IsMasterProtein" "P13674" "Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2" "0.000" "False" "43.730" "17" "8" "10" "8" "534" "61.0" "6.01" "30.56" "8" "cell organization and biogenesis" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf08336, Pf13640" "5033" "ENSG00000122884" "P4HA1" "C9JL12; hsa:5033; P13674; Q15082; Q15083; Q5VSQ5" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "1.006" "0.954" "0.981" "1.016" "1.018" "1.048" "0.985" "1.070" "1.043" "446.9" "449.5" "426.3" "438.2" "454.1" "455.0" "468.3" "440.3" "478.2" "466.0" "" "" "" "" "" "" "" "" "" "" "358.9" "324.3" "338.6" "293.6" "314.1" "341.4" "327.9" "321.6" "478.2" "378.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2561010377563702326" "False" "High" "IsMasterProtein" "Q8WX92" "Negative elongation factor B OS=Homo sapiens OX=9606 GN=NELFB PE=1 SV=1" "0.000" "False" "43.729" "15" "9" "16" "9" "580" "65.7" "6.13" "50.49" "9" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06209" "25920" "ENSG00000188986" "NELFB" "A0A0X1KG71; A2BFA3; hsa:25920; Q8WX92; Q96EW5; Q9H9R4; Q9ULN8; Q9Y3W0" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; NTRK3 as a dependence receptor" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation; 5q35 copy number variation" "18" "0" "1.024" "1.021" "1.016" "1.005" "1.030" "0.942" "1.020" "1.048" "1.009" "1614.0" "1652.0" "1647.6" "1639.9" "1621.7" "1662.9" "1519.8" "1645.7" "1691.5" "1628.9" "" "" "" "" "" "" "" "" "" "" "1296.3" "1192.0" "1308.7" "1098.7" "1121.6" "1247.7" "1064.1" "1201.8" "1691.5" "1324.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-221730190353322517" "False" "High" "IsMasterProtein" "Q9UL63" "Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2" "0.000" "False" "43.721" "13" "8" "10" "8" "735" "84.7" "6.34" "33.64" "8" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf06588, Pf13415" "4289" "ENSG00000128585" "MKLN1" "A4D1M8; A6NG43; hsa:4289; Q9NSK4; Q9NUS8; Q9UL63" "" "Ciliary landscape" "1" "0" "1.022" "1.040" "1.092" "1.038" "1.013" "1.088" "1.035" "1.011" "1.060" "868.0" "886.8" "903.0" "947.6" "901.4" "879.1" "944.2" "898.6" "877.7" "920.3" "" "" "" "" "" "" "" "" "" "" "697.2" "639.9" "717.3" "634.9" "623.4" "659.6" "661.1" "656.3" "877.7" "748.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5305679341133587567" "False" "High" "IsMasterProtein" "Q86WR0" "Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2" "0.000" "False" "43.696" "47" "10" "18" "10" "208" "24.5" "6.80" "54.08" "10" "other biological processes" "plasma membrane;other membranes;other cell component" "nucleic acid binding activity" "Pf05670" "55246" "ENSG00000147419" "CCDC25" "hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98" "" "" "0" "0" "0.954" "0.974" "0.923" "0.886" "0.943" "0.898" "0.878" "0.912" "0.876" "1856.3" "1771.1" "1808.5" "1713.6" "1644.5" "1750.9" "1667.5" "1629.5" "1692.6" "1626.8" "" "" "" "" "" "" "" "" "" "" "1491.0" "1278.0" "1436.5" "1148.1" "1137.4" "1313.6" "1167.5" "1190.1" "1692.6" "1323.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "699961986535192658" "False" "High" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "0.000" "False" "43.694" "40" "6" "11" "5" "191" "21.3" "8.12" "31.62" "6" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Neutrophil degranulation; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHOG GTPase cycle; RHO GTPases activate KTN1" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "8" "0" "1.156" "1.042" "0.995" "1.023" "1.111" "0.949" "1.087" "1.084" "1.068" "206.6" "238.9" "215.2" "205.7" "211.3" "229.5" "196.0" "224.6" "223.9" "220.7" "" "" "" "" "" "" "" "" "" "" "165.9" "172.4" "171.0" "137.8" "146.2" "172.2" "137.2" "164.0" "223.9" "179.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123043622142940735" "False" "High" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "0.000" "False" "43.662" "35" "6" "10" "6" "182" "20.7" "8.69" "33.04" "6" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Platelet degranulation" "Orexin receptor pathway" "2" "0" "1.019" "1.011" "0.962" "1.018" "1.049" "1.060" "1.057" "1.000" "0.996" "1602.2" "1632.9" "1620.4" "1541.9" "1631.7" "1680.2" "1698.9" "1694.1" "1602.1" "1595.6" "" "" "" "" "" "" "" "" "" "" "1286.9" "1178.2" "1287.2" "1033.1" "1128.5" "1260.7" "1189.5" "1237.2" "1602.1" "1297.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557205944014884156" "False" "High" "IsMasterProtein" "P20339" "Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2" "0.000" "False" "43.659" "41" "7" "12" "4" "215" "23.6" "8.15" "36.60" "7" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5868" "ENSG00000144566" "RAB5A" "B4DJA5; hsa:5868; P20339; Q6FI44" "Synthesis of PIPs at the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; Factors involved in megakaryocyte development and platelet production; Prevention of phagosomal-lysosomal fusion; TBC/RABGAPs" "Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; Vasopressin-regulated water reabsorption" "16" "0" "0.970" "0.899" "1.037" "0.999" "0.961" "0.885" "0.954" "1.001" "0.881" "176.0" "170.6" "158.2" "182.5" "175.8" "169.2" "155.7" "167.8" "176.1" "155.1" "" "" "" "" "" "" "" "" "" "" "141.3" "123.1" "125.6" "122.3" "121.6" "126.9" "109.0" "122.6" "176.1" "126.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200930033631648957" "False" "High" "IsMasterProtein" "Q06413" "Myocyte-specific enhancer factor 2C OS=Homo sapiens OX=9606 GN=MEF2C PE=1 SV=1" "0.000" "False" "43.651" "18" "7" "9" "5" "473" "51.2" "8.03" "31.97" "7" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4208" "ENSG00000081189" "MEF2C" "C9JMZ0; D7F7N5; F8W7V7; hsa:4208; Q06413" "ERK/MAPK targets; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis; Cardiogenesis; MECP2 regulates transcription factors" "Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Prion disease pathway; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GDNF signaling; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "30" "0" "0.949" "0.892" "0.878" "0.891" "0.847" "0.762" "0.924" "0.871" "0.855" "546.8" "519.0" "488.0" "479.8" "487.0" "463.0" "416.9" "505.3" "476.2" "467.3" "" "" "" "" "" "" "" "" "" "" "439.2" "374.5" "387.6" "321.5" "336.8" "347.4" "291.9" "369.0" "476.2" "380.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7507804791058133428" "False" "High" "IsMasterProtein" "Q9NX74" "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens OX=9606 GN=DUS2 PE=1 SV=1" "0.000" "False" "43.623" "23" "10" "11" "10" "493" "55.0" "7.11" "33.76" "10" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf01207" "54920" "ENSG00000167264" "DUS2" "A8K3G3; hsa:54920; Q4H4D9; Q9NX74" "PKR-mediated signaling; tRNA modification in the nucleus and cytosol" "" "2" "0" "1.010" "0.965" "1.089" "1.173" "1.043" "0.979" "0.997" "0.945" "1.027" "129.9" "131.3" "125.3" "141.5" "152.4" "135.5" "127.2" "129.6" "122.9" "133.4" "" "" "" "" "" "" "" "" "" "" "104.4" "94.7" "99.6" "94.8" "105.4" "101.6" "89.0" "94.6" "122.9" "108.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5234927014907967079" "False" "High" "IsMasterProtein" "Q9H0S4" "Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1" "0.000" "False" "43.608" "20" "8" "10" "8" "455" "50.6" "9.10" "31.49" "8" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "nucleus" "other molecular function" "Pf00270, Pf00271" "51202" "ENSG00000213782" "DDX47" "B3KXP4; G5E955; hsa:51202; Q96GM0; Q96NV8; Q9H0S4; Q9UI98" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.002" "1.051" "1.115" "1.088" "1.116" "1.139" "1.085" "1.042" "1.082" "745.0" "746.7" "782.8" "830.5" "810.2" "831.5" "848.8" "808.2" "776.0" "806.3" "" "" "" "" "" "" "" "" "" "" "598.4" "538.8" "621.8" "556.4" "560.4" "623.9" "594.3" "590.3" "776.0" "655.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7224643183628006691" "False" "High" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "0.000" "False" "43.533" "20" "7" "15" "7" "357" "37.5" "5.45" "48.06" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "9" "0" "0.983" "1.117" "1.075" "1.025" "1.028" "1.006" "1.084" "1.044" "1.049" "678.7" "667.3" "758.4" "729.8" "695.8" "698.1" "683.1" "735.5" "708.7" "712.2" "" "" "" "" "" "" "" "" "" "" "545.1" "481.5" "602.4" "489.0" "481.2" "523.7" "478.3" "537.1" "708.7" "579.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1355905293603533123" "False" "High" "IsMasterProtein" "Q9Y2Z2" "Protein MTO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MTO1 PE=1 SV=2" "0.000" "False" "43.523" "17" "12" "12" "12" "717" "79.9" "8.31" "38.79" "12" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01134, Pf13932, Pf21680" "25821" "ENSG00000135297" "MTO1" "B3KQB5; hsa:25821; Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; Q9Y2Z2" "tRNA modification in the mitochondrion" "" "1" "0" "1.065" "0.996" "1.033" "1.064" "1.044" "0.963" "1.082" "1.075" "1.029" "863.6" "919.7" "860.4" "892.3" "918.5" "901.2" "831.5" "934.5" "928.6" "888.4" "" "" "" "" "" "" "" "" "" "" "693.6" "663.6" "683.4" "597.9" "635.2" "676.2" "582.2" "682.5" "928.6" "722.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1851911761268984934" "False" "High" "IsMasterProtein" "O00418" "Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2" "0.000" "False" "43.474" "17" "13" "15" "13" "725" "82.1" "5.33" "42.87" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf02816" "29904" "ENSG00000103319" "EEF2K" "hsa:29904; O00418; Q8N588" "mTORC1-mediated signalling" "Translation factors; AMP-activated protein kinase signaling; BDNF-TrkB signaling" "4" "0" "0.996" "0.998" "0.937" "0.952" "0.957" "0.870" "0.970" "0.965" "0.948" "1105.0" "1100.3" "1103.1" "1035.3" "1052.4" "1057.2" "960.8" "1071.3" "1066.1" "1047.5" "" "" "" "" "" "" "" "" "" "" "887.5" "794.0" "876.2" "693.6" "727.8" "793.2" "672.7" "782.4" "1066.1" "851.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2821733550000515702" "False" "High" "IsMasterProtein" "Q9NX46" "ADP-ribosylhydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1" "0.000" "False" "43.447" "27" "8" "11" "8" "363" "38.9" "5.07" "37.08" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03747" "54936" "ENSG00000116863" "ADPRS" "hsa:54936; Q53G94; Q6IAB8; Q9BY47; Q9NX46" "POLB-Dependent Long Patch Base Excision Repair" "" "1" "0" "1.001" "0.999" "0.933" "0.986" "0.982" "0.945" "0.997" "0.975" "1.005" "1171.6" "1172.3" "1170.1" "1093.0" "1155.2" "1150.4" "1106.9" "1167.9" "1142.4" "1177.8" "" "" "" "" "" "" "" "" "" "" "941.0" "845.9" "929.4" "732.3" "799.0" "863.2" "775.0" "852.9" "1142.4" "957.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043384267201458756" "False" "High" "IsMasterProtein" "Q8TBX8" "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3" "0.000" "False" "43.424" "24" "10" "17" "10" "421" "47.3" "6.84" "46.62" "10" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "79837" "ENSG00000166908" "PIP4K2C" "B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton" "5" "0" "1.009" "0.986" "1.024" "1.049" "1.016" "1.023" "1.010" "1.040" "1.005" "679.5" "685.4" "669.8" "695.6" "712.5" "690.2" "694.9" "686.6" "707.0" "682.8" "" "" "" "" "" "" "" "" "" "" "545.8" "494.5" "532.0" "466.0" "492.7" "517.9" "486.5" "501.4" "707.0" "555.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6978047849896927875" "False" "High" "IsMasterProtein" "O15234" "Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2" "0.000" "False" "43.394" "12" "7" "9" "7" "703" "76.2" "6.48" "36.70" "7" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09405" "22794" "ENSG00000108349" "CASC3" "A8K8R0; O15234" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "6" "0" "1.000" "0.953" "0.956" "1.012" "1.003" "0.915" "1.006" "0.952" "0.986" "733.6" "733.5" "699.3" "701.4" "742.3" "736.1" "671.6" "738.2" "698.5" "723.0" "" "" "" "" "" "" "" "" "" "" "589.2" "529.2" "555.5" "469.9" "513.4" "552.3" "470.2" "539.1" "698.5" "588.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3823742586445689125" "False" "High" "IsMasterProtein" "Q9NPQ8" "Synembryn-A OS=Homo sapiens OX=9606 GN=RIC8A PE=1 SV=3" "0.000" "False" "43.310" "14" "5" "7" "5" "531" "59.7" "5.33" "29.96" "5" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf10165" "60626" "ENSG00000177963" "RIC8A" "hsa:60626; Q0P508; Q2T9J1; Q7Z352; Q96EZ1; Q96SZ2; Q9H064; Q9H5H3; Q9H9E7; Q9NPQ8" "" "" "0" "0" "0.963" "0.909" "0.984" "0.975" "1.013" "1.017" "0.972" "1.034" "1.015" "362.3" "349.1" "329.2" "356.6" "353.4" "367.2" "368.5" "352.3" "374.6" "367.7" "" "" "" "" "" "" "" "" "" "" "291.0" "251.9" "261.5" "238.9" "244.4" "275.5" "258.0" "257.3" "374.6" "299.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3114366665604462397" "False" "High" "IsMasterProtein" "Q9BZE2" "tRNA pseudouridine(38/39) synthase OS=Homo sapiens OX=9606 GN=PUS3 PE=1 SV=3" "0.000" "False" "43.286" "15" "7" "11" "7" "481" "55.6" "7.49" "40.38" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "83480" "ENSG00000110060" "PUS3" "B2RAM0; hsa:83480; Q96D17; Q96J23; Q96NB4; Q9BZE2" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.089" "0.990" "1.057" "1.051" "0.932" "1.097" "1.029" "1.033" "1.075" "413.9" "450.8" "409.7" "437.4" "434.8" "385.8" "454.0" "425.7" "427.7" "444.7" "" "" "" "" "" "" "" "" "" "" "332.4" "325.3" "325.4" "293.1" "300.7" "289.4" "317.8" "310.9" "427.7" "361.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3710113209643881705" "False" "High" "IsMasterProtein" "O75794" "Translation initiation factor eIF2 assembly protein OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1" "0.000" "False" "43.276" "23" "7" "12" "7" "336" "39.1" "4.81" "46.10" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "" "Pf07065" "8872" "ENSG00000151465" "CDC123" "A8JZZ7; hsa:8872; O75794; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9" "" "" "0" "0" "0.990" "0.966" "0.971" "0.980" "0.958" "1.005" "1.031" "0.935" "1.023" "1303.1" "1289.7" "1259.3" "1265.4" "1276.6" "1248.0" "1309.1" "1344.1" "1218.6" "1333.7" "" "" "" "" "" "" "" "" "" "" "1046.7" "930.6" "1000.3" "847.8" "882.9" "936.3" "916.6" "981.6" "1218.6" "1084.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3343567279109484109" "False" "High" "IsMasterProtein" "P61326" "Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1" "0.000" "False" "43.273" "46" "7" "20" "7" "146" "17.2" "6.11" "63.98" "7" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus" "" "Pf02792" "4116" "ENSG00000162385" "MAGOH" "B1ARP8; B2R5A2; hsa:4116; O35169; P50606; P61326; Q5SW69" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "TAR syndrome" "7" "0" "0.953" "1.046" "0.921" "0.949" "0.967" "0.870" "0.902" "0.864" "0.944" "2718.2" "2591.4" "2842.0" "2503.8" "2580.4" "2629.5" "2365.4" "2452.4" "2349.8" "2566.9" "" "" "" "" "" "" "" "" "" "" "2183.2" "1869.9" "2257.5" "1677.5" "1784.6" "1972.9" "1656.1" "1791.0" "2349.8" "2087.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314773965349869651" "False" "High" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "0.000" "False" "43.271" "43" "6" "12" "6" "204" "22.6" "9.45" "46.78" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "" "TAR syndrome" "1" "0" "1.070" "1.031" "1.041" "1.042" "1.045" "1.028" "1.036" "1.021" "1.003" "979.5" "1047.7" "1010.0" "1019.4" "1021.0" "1023.7" "1007.3" "1014.6" "1000.3" "982.3" "" "" "" "" "" "" "" "" "" "" "786.7" "756.0" "802.3" "683.0" "706.1" "768.0" "705.2" "741.0" "1000.3" "798.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594484432885072185" "False" "High" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "0.000" "False" "43.270" "36" "8" "11" "8" "272" "31.4" "5.91" "37.77" "8" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "" "Ciliary landscape" "1" "0" "0.988" "1.014" "0.991" "0.970" "1.020" "0.933" "0.996" "0.975" "0.997" "761.1" "751.7" "771.6" "753.8" "737.9" "776.1" "709.8" "758.0" "742.3" "758.5" "" "" "" "" "" "" "" "" "" "" "611.3" "542.4" "612.9" "505.1" "510.3" "582.3" "497.0" "553.5" "742.3" "616.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "460406497697363824" "False" "High" "IsMasterProtein" "P61018" "Ras-related protein Rab-4B OS=Homo sapiens OX=9606 GN=RAB4B PE=1 SV=1" "0.000" "False" "43.237" "33" "6" "12" "3" "213" "23.6" "6.06" "42.85" "6" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53916" "ENSG00000167578" "RAB4B" "hsa:53916; P22750; P61018; Q7Z514; Q9HBR6" "Neutrophil degranulation; RAB geranylgeranylation; MET receptor recycling" "Intracellular trafficking proteins involved in CMT neuropathy" "4" "1" "1.124" "1.040" "1.110" "1.141" "1.098" "1.038" "1.086" "1.099" "1.113" "622.0" "699.1" "646.8" "690.4" "709.5" "682.9" "645.4" "675.7" "683.4" "692.1" "" "" "" "" "" "" "" "" "" "" "499.6" "504.5" "513.8" "462.6" "490.7" "512.4" "451.9" "493.5" "683.4" "562.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755213045612558311" "False" "High" "IsMasterProtein" "P53367" "Arfaptin-1 OS=Homo sapiens OX=9606 GN=ARFIP1 PE=1 SV=2" "0.000" "False" "43.236" "22" "8" "12" "7" "373" "41.7" "6.70" "42.33" "8" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf06456" "27236" "ENSG00000164144" "ARFIP1" "B4DS69; hsa:27236; P53367; Q2M2X4; Q3SYL4; Q9Y2X6" "" "" "0" "1" "1.000" "0.971" "0.980" "1.039" "1.001" "0.975" "0.972" "1.013" "1.026" "1514.4" "1514.7" "1471.1" "1484.2" "1573.0" "1516.4" "1477.1" "1472.6" "1533.7" "1554.3" "" "" "" "" "" "" "" "" "" "" "1216.4" "1093.0" "1168.5" "994.4" "1087.9" "1137.7" "1034.2" "1075.5" "1533.7" "1264.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3902641514385650329" "False" "High" "IsMasterProtein" "Q5BKZ1" "DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2" "0.000" "False" "43.234" "20" "9" "11" "9" "582" "65.6" "5.15" "30.48" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "284695" "ENSG00000162664" "ZNF326" "A8MYX1; B4DLN0; B4E179; hsa:284695; Q5BKZ1; Q5VW93; Q5VW94; Q5VW96; Q5VW97; Q6NSA2; Q7Z638; Q7Z6C2" "" "" "0" "0" "0.922" "0.968" "1.024" "1.073" "1.009" "1.133" "1.110" "1.090" "1.088" "571.7" "526.9" "553.4" "585.7" "613.4" "576.6" "647.9" "634.3" "623.4" "622.3" "" "" "" "" "" "" "" "" "" "" "459.2" "380.2" "439.6" "392.4" "424.2" "432.6" "453.6" "463.2" "623.4" "506.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978965257736533934" "False" "High" "IsMasterProtein" "Q9NYK5" "Large ribosomal subunit protein mL39 OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "0.000" "False" "43.221" "17" "6" "8" "6" "338" "38.7" "7.65" "30.22" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.963" "0.989" "0.944" "0.999" "1.018" "0.925" "0.958" "0.979" "0.997" "950.4" "915.2" "939.9" "897.0" "949.2" "967.9" "879.3" "910.1" "930.7" "947.2" "" "" "" "" "" "" "" "" "" "" "763.4" "660.4" "746.6" "601.0" "656.5" "726.2" "615.7" "664.6" "930.7" "770.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6359108141380896600" "False" "High" "IsMasterProtein" "Q86W50" "RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2" "0.000" "False" "43.212" "13" "7" "9" "7" "562" "63.6" "7.85" "33.06" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05971" "79066" "ENSG00000127804" "METTL16" "D3DTI8; hsa:79066; Q86TE5; Q86W50; Q96T16; Q9BVG7" "" "" "0" "0" "1.059" "1.024" "0.956" "0.931" "0.895" "0.917" "0.955" "0.944" "0.996" "1125.1" "1191.2" "1151.7" "1075.2" "1047.2" "1006.8" "1031.7" "1074.8" "1061.6" "1120.3" "" "" "" "" "" "" "" "" "" "" "903.7" "859.5" "914.8" "720.4" "724.2" "755.4" "722.3" "785.0" "1061.6" "911.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1583650821826420104" "False" "High" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "0.000" "False" "43.205" "15" "9" "12" "9" "744" "82.3" "7.78" "36.75" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973; ENSG00000291502" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "M-decay: degradation of maternal mRNAs by maternally stored factors; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "Ciliary landscape" "4" "0" "0.939" "0.848" "0.944" "0.834" "0.944" "0.842" "0.848" "0.834" "0.831" "1243.1" "1167.1" "1054.4" "1173.0" "1037.2" "1172.9" "1046.5" "1054.4" "1036.9" "1033.4" "" "" "" "" "" "" "" "" "" "" "998.4" "842.2" "837.5" "785.9" "717.3" "880.0" "732.7" "770.0" "1036.9" "840.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687801448742430149" "False" "High" "IsMasterProtein" "Q9H4A6" "Golgi phosphoprotein 3 OS=Homo sapiens OX=9606 GN=GOLPH3 PE=1 SV=1" "0.000" "False" "43.196" "28" "7" "9" "6" "298" "33.8" "6.44" "33.92" "7" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05719" "64083" "ENSG00000113384" "GOLPH3" "hsa:64083; Q9H4A6; Q9UIW5" "" "" "0" "1" "1.155" "1.049" "1.271" "1.177" "1.126" "1.205" "1.127" "1.193" "1.159" "467.0" "539.4" "489.8" "593.6" "549.7" "525.8" "562.8" "526.2" "556.9" "541.2" "" "" "" "" "" "" "" "" "" "" "375.1" "389.2" "389.1" "397.7" "380.2" "394.5" "394.0" "384.3" "556.9" "440.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9158242191706838173" "False" "High" "IsMasterProtein" "Q71RC2" "La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3" "0.000" "False" "43.188" "16" "10" "14" "10" "724" "80.5" "6.61" "42.29" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383" "113251" "ENSG00000161813" "LARP4" "A8K6T1; E9PDG5; G3XAA8; G5E976; hsa:113251; Q5CZ97; Q6ZV14; Q71RC2; Q96NF9" "" "" "0" "0" "1.003" "1.046" "1.053" "1.056" "1.078" "1.092" "1.046" "1.118" "1.075" "1202.6" "1206.4" "1258.0" "1266.8" "1269.4" "1296.2" "1312.8" "1257.9" "1344.9" "1293.2" "" "" "" "" "" "" "" "" "" "" "965.9" "870.5" "999.3" "848.7" "877.9" "972.5" "919.2" "918.7" "1344.9" "1051.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5842118922115640430" "False" "High" "IsMasterProtein" "P36405" "ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2" "0.000" "False" "43.183" "48" "7" "10" "7" "182" "20.4" "7.24" "30.20" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "403" "ENSG00000138175" "ARL3" "B2R6C7; hsa:403; P36405; Q53X83; Q5JSM2" "Trafficking of myristoylated proteins to the cilium" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "5" "0" "0.973" "0.931" "1.006" "1.019" "1.058" "1.060" "0.998" "0.965" "1.015" "559.5" "544.3" "520.9" "563.0" "570.1" "591.7" "593.0" "558.6" "539.8" "567.9" "" "" "" "" "" "" "" "" "" "" "449.4" "392.8" "413.8" "377.2" "394.3" "444.0" "415.2" "407.9" "539.8" "461.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5034217840069919209" "False" "High" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "0.000" "False" "43.179" "36" "8" "11" "8" "258" "29.0" "5.81" "39.16" "8" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Neutrophil degranulation; Intra-Golgi traffic" "Ciliary landscape; 22q11.2 copy number variation syndrome" "4" "0" "1.072" "0.931" "1.078" "1.084" "0.997" "1.089" "1.089" "1.040" "1.083" "794.4" "852.0" "739.8" "856.2" "861.0" "791.7" "864.8" "865.5" "826.2" "860.5" "" "" "" "" "" "" "" "" "" "" "638.1" "614.8" "587.7" "573.6" "595.5" "594.0" "605.5" "632.0" "826.2" "699.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4563440572163449089" "False" "High" "IsMasterProtein" "P60520" "Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1" "0.000" "False" "43.152" "45" "7" "14" "5" "117" "13.7" "8.10" "47.23" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11345" "ENSG00000034713" "GABARAPL2" "hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7" "TBC/RABGAPs; Macroautophagy" "Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "5" "2" "1.011" "0.991" "0.963" "1.054" "1.083" "0.991" "0.969" "1.054" "0.979" "1803.6" "1822.7" "1787.5" "1736.1" "1901.1" "1954.2" "1787.9" "1748.6" "1901.8" "1765.7" "" "" "" "" "" "" "" "" "" "" "1448.6" "1315.2" "1419.9" "1163.2" "1314.8" "1466.2" "1251.8" "1277.0" "1901.8" "1436.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1875589299266399931" "False" "High" "IsMasterProtein" "Q14139" "Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2" "0.000" "False" "43.120" "12" "11" "12" "11" "1066" "122.5" "5.24" "36.33" "11" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "9354" "ENSG00000110344" "UBE4A" "B0YJB6; Q14139; Q2M1H0; Q6P5T4; Q7Z639" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.977" "0.979" "1.048" "1.075" "1.022" "1.046" "1.023" "1.045" "1.103" "968.2" "945.7" "947.6" "1015.1" "1040.8" "989.3" "1012.4" "990.5" "1011.5" "1067.5" "" "" "" "" "" "" "" "" "" "" "777.6" "682.4" "752.7" "680.1" "719.8" "742.3" "708.8" "723.3" "1011.5" "868.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-573717286669998035" "False" "High" "IsMasterProtein" "Q9BY43" "Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3" "0.000" "False" "43.085" "40" "8" "12" "8" "222" "25.1" "4.70" "36.23" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "29082" "ENSG00000254505; ENSG00000285302" "CHMP4A" "hsa:29082; Q14D22; Q32Q79; Q86SZ8; Q96QJ9; Q9BY43; Q9P026" "HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "0.950" "0.928" "0.928" "0.914" "0.994" "1.007" "0.953" "0.928" "0.959" "1635.9" "1553.3" "1517.5" "1517.7" "1495.8" "1625.6" "1648.0" "1559.4" "1517.6" "1568.6" "" "" "" "" "" "" "" "" "" "" "1313.9" "1120.8" "1205.4" "1016.9" "1034.5" "1219.7" "1153.9" "1138.8" "1517.6" "1275.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857120018545354279" "False" "High" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "0.000" "False" "43.047" "20" "7" "10" "7" "380" "42.1" "5.63" "41.77" "7" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "Separation of Sister Chromatids; Regulation of HSF1-mediated heat shock response; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "1.136" "1.078" "1.113" "1.165" "1.138" "0.994" "1.164" "1.173" "1.133" "401.5" "456.2" "432.7" "446.9" "467.9" "457.0" "399.0" "467.3" "470.9" "454.8" "" "" "" "" "" "" "" "" "" "" "322.5" "329.2" "343.7" "299.4" "323.6" "342.9" "279.4" "341.3" "470.9" "369.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740771680866674362" "False" "High" "IsMasterProtein" "P62993" "Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1" "0.000" "False" "43.045" "35" "7" "17" "7" "217" "25.2" "6.32" "47.86" "7" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "2885" "ENSG00000177885" "GRB2" "hsa:2885; P29354; P62993; Q14450; Q63057; Q63059" "Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "73" "0" "0.954" "0.942" "0.921" "0.937" "0.936" "0.972" "0.884" "0.936" "0.930" "1404.9" "1340.5" "1323.6" "1293.2" "1316.0" "1315.5" "1366.2" "1242.5" "1314.8" "1307.0" "" "" "" "" "" "" "" "" "" "" "1128.4" "967.3" "1051.3" "866.5" "910.2" "987.0" "956.6" "907.4" "1314.8" "1062.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5749593247568362596" "False" "High" "IsMasterProtein" "Q9NYV4" "Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2" "0.000" "False" "43.039" "7" "9" "13" "7" "1490" "164.1" "9.44" "37.62" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "51755" "ENSG00000167258" "CDK12" "A7E2B2; B4DYX4; B9EIQ6; hsa:51755; O94978; Q9NYV4" "TP53 Regulates Transcription of DNA Repair Genes" "17q12 copy number variation syndrome" "2" "0" "0.989" "0.997" "1.090" "1.076" "0.998" "1.106" "1.051" "1.091" "1.063" "734.7" "726.5" "732.8" "801.0" "790.3" "733.5" "812.4" "772.2" "801.5" "780.9" "" "" "" "" "" "" "" "" "" "" "590.1" "524.2" "582.0" "536.7" "546.6" "550.3" "568.8" "564.0" "801.5" "635.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-274346279625731140" "False" "High" "IsMasterProtein" "O00471" "Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1" "0.000" "False" "42.999" "17" "11" "15" "11" "708" "81.8" "6.71" "42.60" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf07393, Pf20667" "10640" "ENSG00000070367" "EXOC5" "B2R6C5; hsa:10640; O00471; Q8IW24" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "0.999" "1.064" "1.007" "0.997" "0.960" "0.962" "1.009" "1.022" "1.079" "885.4" "884.8" "941.7" "891.3" "883.0" "850.4" "852.1" "893.1" "904.7" "955.7" "" "" "" "" "" "" "" "" "" "" "711.1" "638.4" "748.0" "597.2" "610.7" "638.0" "596.6" "652.2" "904.7" "777.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3114131480513419355" "False" "High" "IsMasterProtein" "P62701" "Small ribosomal subunit protein eS4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "0.000" "False" "42.948" "35" "8" "12" "8" "263" "29.6" "10.15" "38.84" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.959" "1.197" "1.038" "1.093" "1.078" "0.984" "1.104" "1.116" "1.055" "769.9" "738.3" "921.8" "798.9" "841.1" "829.9" "757.3" "849.8" "858.9" "811.9" "" "" "" "" "" "" "" "" "" "" "618.4" "532.8" "732.2" "535.3" "581.7" "622.6" "530.2" "620.6" "858.9" "660.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049594169438393906" "False" "High" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "0.000" "False" "42.945" "18" "6" "12" "5" "433" "45.5" "8.69" "40.98" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "tRNA processing in the nucleus" "" "1" "0" "0.982" "0.961" "1.082" "0.906" "0.890" "0.980" "0.871" "0.901" "0.924" "585.9" "575.6" "562.8" "634.3" "530.7" "521.4" "574.0" "510.2" "528.1" "541.5" "" "" "" "" "" "" "" "" "" "" "470.6" "415.3" "447.1" "425.0" "367.0" "391.2" "401.9" "372.6" "528.1" "440.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7866800410965669169" "False" "High" "IsMasterProtein" "Q9H0G5" "Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1" "0.000" "False" "42.930" "16" "9" "13" "9" "558" "66.4" "8.84" "42.65" "9" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09745, Pf20427" "84081" "ENSG00000126653" "NSRP1" "hsa:84081; Q6FI71; Q9H0G5" "mRNA Splicing - Major Pathway" "" "1" "0" "1.044" "1.034" "1.061" "0.974" "1.040" "0.980" "0.943" "0.952" "0.978" "1069.9" "1116.6" "1106.4" "1135.1" "1042.5" "1112.4" "1048.4" "1009.1" "1019.0" "1045.8" "" "" "" "" "" "" "" "" "" "" "859.3" "805.7" "878.8" "760.5" "721.0" "834.6" "734.0" "736.9" "1019.0" "850.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4783590985173723979" "False" "High" "IsMasterProtein" "Q96CN7" "Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3" "0.000" "False" "42.904" "27" "6" "15" "6" "298" "32.2" "7.39" "47.47" "6" "" "other cytoplasmic organelle;other cell component" "" "Pf00857" "51015" "ENSG00000066583" "ISOC1" "hsa:51015; Q7Z770; Q96CN7" "" "" "0" "0" "1.072" "1.027" "1.064" "1.046" "1.028" "1.026" "1.067" "1.068" "1.053" "909.7" "975.3" "934.5" "967.8" "951.3" "935.1" "933.5" "970.8" "971.4" "957.9" "" "" "" "" "" "" "" "" "" "" "730.7" "703.7" "742.3" "648.4" "658.0" "701.6" "653.6" "709.0" "971.4" "779.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625038226073765913" "False" "High" "IsMasterProtein" "P61421" "V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1" "0.000" "False" "42.881" "32" "9" "10" "9" "351" "40.3" "5.00" "35.96" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01992" "9114" "ENSG00000159720" "ATP6V0D1" "hsa:9114; P12953; P61421; Q02547" "Amino acids regulate mTORC1; XBP1(S) activates chaperone genes; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "VEGFA-VEGFR2 signaling" "7" "0" "1.013" "1.038" "0.966" "0.998" "1.033" "0.962" "1.116" "1.100" "1.088" "712.2" "721.6" "739.4" "688.0" "710.9" "735.6" "684.8" "794.6" "783.8" "774.6" "" "" "" "" "" "" "" "" "" "" "572.0" "520.7" "587.4" "461.0" "491.6" "551.9" "479.5" "580.3" "783.8" "629.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6481945204603063978" "False" "High" "IsMasterProtein" "Q9UBB6" "Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1" "0.000" "False" "42.838" "9" "6" "10" "6" "729" "78.8" "5.48" "38.89" "6" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf05536" "23154" "ENSG00000020129" "NCDN" "D3DPR9; hsa:23154; Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9" "" "Splicing factor NOVA regulated synaptic proteins" "1" "0" "1.021" "1.001" "1.050" "1.032" "0.937" "1.002" "1.062" "1.006" "0.963" "1090.1" "1112.8" "1091.2" "1144.4" "1125.4" "1021.5" "1092.8" "1157.3" "1096.3" "1049.9" "" "" "" "" "" "" "" "" "" "" "875.6" "803.0" "866.8" "766.7" "778.4" "766.4" "765.1" "845.2" "1096.3" "853.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5852345656663566721" "False" "High" "IsMasterProtein" "Q5JSL3" "Dedicator of cytokinesis protein 11 OS=Homo sapiens OX=9606 GN=DOCK11 PE=1 SV=2" "0.000" "False" "42.789" "7" "14" "14" "14" "2073" "237.5" "7.74" "43.58" "14" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "139818" "ENSG00000147251" "DOCK11" "A6NMF0; hsa:139818; Q5JSL3; Q66M66; Q6ZUJ5; Q86VU8; Q96MN3" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "" "3" "0" "1.006" "0.995" "1.015" "1.027" "1.010" "1.067" "1.074" "1.039" "1.027" "1476.0" "1484.7" "1468.9" "1498.3" "1515.2" "1491.0" "1574.6" "1585.6" "1533.9" "1515.9" "" "" "" "" "" "" "" "" "" "" "1185.5" "1071.3" "1166.8" "1003.8" "1047.9" "1118.7" "1102.4" "1158.0" "1533.9" "1232.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8336959389003651340" "False" "High" "IsMasterProtein" "Q9NZJ4" "Sacsin OS=Homo sapiens OX=9606 GN=SACS PE=1 SV=2" "0.000" "False" "42.742" "3" "12" "12" "12" "4579" "520.8" "7.05" "36.26" "12" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00240, Pf05168" "26278" "ENSG00000151835" "SACS" "hsa:26278; O94835; Q5T9J5; Q5T9J7; Q5T9J8; Q68DF5; Q6MZR4; Q8NBF9; Q9NZJ4" "" "13q12.12 copy number variation" "1" "0" "1.070" "1.030" "1.151" "1.259" "1.228" "1.118" "1.088" "1.031" "1.121" "270.8" "289.7" "278.9" "311.7" "341.0" "332.5" "302.7" "294.6" "279.2" "303.7" "" "" "" "" "" "" "" "" "" "" "217.5" "209.1" "221.5" "208.8" "235.8" "249.5" "212.0" "215.1" "279.2" "246.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7333180136300150104" "False" "High" "IsMasterProtein" "Q96S44" "EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2" "0.000" "False" "42.725" "37" "8" "15" "8" "253" "28.1" "9.54" "41.07" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf06293" "112858" "ENSG00000172315" "TP53RK" "B3KU44; hsa:112858; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q96S44; Q9NQE6" "tRNA modification in the nucleus and cytosol; Regulation of TP53 Activity through Phosphorylation" "" "2" "0" "0.942" "0.971" "0.802" "0.901" "0.944" "0.874" "0.904" "0.880" "0.917" "431.2" "406.4" "418.6" "346.0" "388.7" "407.0" "376.8" "389.8" "379.7" "395.5" "" "" "" "" "" "" "" "" "" "" "346.4" "293.2" "332.5" "231.8" "268.8" "305.3" "263.8" "284.7" "379.7" "321.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5241124612822470915" "False" "High" "IsMasterProtein" "P36639" "Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4" "0.000" "False" "42.722" "26" "3" "8" "3" "156" "17.9" "5.08" "37.00" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "4521" "ENSG00000106268" "NUDT1" "A4D205; hsa:4521; P36639; Q6LES7; Q6P0Y6; Q7Z7N6; Q8IV95; Q9UBM0; Q9UBM9" "" "" "0" "0" "1.004" "0.962" "0.976" "1.038" "0.981" "0.990" "0.997" "0.978" "0.963" "1169.8" "1173.9" "1125.0" "1142.3" "1214.8" "1147.6" "1157.7" "1166.3" "1144.5" "1126.4" "" "" "" "" "" "" "" "" "" "" "939.6" "847.1" "893.6" "765.3" "840.2" "861.0" "810.6" "851.8" "1144.5" "916.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726167102893575460" "False" "High" "IsMasterProtein" "Q7Z4H7" "HAUS augmin-like complex subunit 6 OS=Homo sapiens OX=9606 GN=HAUS6 PE=1 SV=2" "0.000" "False" "42.714" "15" "13" "13" "13" "955" "108.6" "6.47" "38.63" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14661" "54801" "ENSG00000147874" "HAUS6" "B3KPK4; B4DX82; hsa:54801; Q05CG1; Q14CB6; Q14CD9; Q2TA91; Q6IQ10; Q6NZX5; Q7Z4H7; Q8IZQ4; Q96FN0; Q9H950; Q9H998; Q9HCJ8; Q9NXT8" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.104" "0.980" "1.079" "1.098" "0.992" "1.049" "1.080" "1.046" "1.043" "828.8" "915.0" "812.5" "894.0" "909.7" "822.3" "869.2" "895.1" "867.0" "864.1" "" "" "" "" "" "" "" "" "" "" "665.7" "660.2" "645.4" "599.0" "629.1" "617.0" "608.6" "653.7" "867.0" "702.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535429357355427418" "False" "High" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "0.000" "False" "42.686" "39" "7" "13" "7" "225" "24.3" "7.94" "47.47" "7" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "Ciliary landscape" "3" "0" "0.971" "0.967" "1.043" "1.007" "0.936" "0.946" "0.940" "0.905" "0.955" "2454.4" "2383.1" "2372.6" "2560.4" "2472.7" "2298.0" "2322.1" "2308.3" "2221.4" "2344.6" "" "" "" "" "" "" "" "" "" "" "1971.4" "1719.5" "1884.6" "1715.4" "1710.2" "1724.2" "1625.8" "1685.8" "2221.4" "1906.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5495353831656127209" "False" "High" "IsMasterProtein" "Q8ND04" "Nonsense-mediated mRNA decay factor SMG8 OS=Homo sapiens OX=9606 GN=SMG8 PE=1 SV=1" "0.000" "False" "42.669" "11" "9" "10" "9" "991" "109.6" "7.68" "29.77" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol" "" "Pf10220" "55181" "ENSG00000167447" "SMG8" "hsa:55181; Q8N5U5; Q8ND04; Q8TDN0; Q9H5P5; Q9NVQ1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "1.097" "1.040" "1.068" "1.047" "0.964" "0.998" "0.953" "0.938" "1.001" "406.5" "445.9" "422.9" "433.9" "425.4" "391.7" "405.5" "387.3" "381.2" "406.7" "" "" "" "" "" "" "" "" "" "" "326.5" "321.7" "335.9" "290.7" "294.2" "293.9" "283.9" "282.9" "381.2" "330.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6149624510723031081" "False" "High" "IsMasterProtein" "P30043" "Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3" "0.000" "False" "42.654" "40" "5" "11" "5" "206" "22.1" "7.65" "39.92" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13460" "645" "ENSG00000090013" "BLVRB" "A6NKD8; B2R5C6; hsa:645; P30043; P32078; P53005; Q32LZ2" "Cytoprotection by HMOX1; Heme degradation" "Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway" "5" "0" "1.032" "0.985" "1.024" "0.999" "1.003" "1.006" "0.927" "0.977" "1.004" "401.8" "414.8" "395.7" "411.5" "401.5" "403.1" "404.1" "372.3" "392.4" "403.3" "" "" "" "" "" "" "" "" "" "" "322.7" "299.3" "314.3" "275.7" "277.7" "302.4" "283.0" "271.9" "392.4" "328.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9010932242184779008" "False" "High" "IsMasterProtein" "P10644" "cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1" "0.000" "False" "42.653" "30" "11" "13" "8" "381" "43.0" "5.35" "40.94" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5573" "ENSG00000108946" "PRKAR1A" "hsa:5573; K7ER48; P10644; Q567S7" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "27" "1" "1.093" "1.043" "1.065" "1.083" "1.017" "1.022" "1.010" "0.975" "1.047" "822.3" "898.8" "857.4" "875.5" "890.4" "836.0" "840.4" "830.7" "801.9" "861.3" "" "" "" "" "" "" "" "" "" "" "660.5" "648.5" "681.1" "586.6" "615.8" "627.3" "588.4" "606.7" "801.9" "700.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5091177938667012153" "False" "High" "IsMasterProtein" "P41743" "Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2" "0.000" "False" "42.619" "15" "7" "11" "5" "596" "68.2" "5.85" "35.87" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5584" "ENSG00000163558" "PRKCI" "D3DNQ4; hsa:5584; P41743; Q8WW06" "KEAP1-NFE2L2 pathway; Tight junction interactions; Pre-NOTCH Transcription and Translation; p75NTR recruits signalling complexes" "Glioblastoma signaling pathways; Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Chronic hyperglycemia impairment of neuron function" "15" "1" "1.073" "0.987" "1.109" "1.065" "1.008" "1.091" "1.038" "0.935" "1.022" "281.4" "301.9" "277.8" "312.2" "299.7" "283.8" "307.0" "292.0" "263.2" "287.5" "" "" "" "" "" "" "" "" "" "" "226.0" "217.8" "220.7" "209.1" "207.3" "212.9" "215.0" "213.3" "263.2" "233.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801369761430289409" "False" "High" "IsMasterProtein" "Q12968" "Nuclear factor of activated T-cells, cytoplasmic 3 OS=Homo sapiens OX=9606 GN=NFATC3 PE=1 SV=1" "0.000" "False" "42.614" "9" "8" "10" "7" "1075" "115.5" "6.37" "31.81" "8" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4775" "ENSG00000072736" "NFATC3" "hsa:4775; O75211; Q12968; Q14516; Q99840; Q99841; Q99842" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "Heart development; B cell receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection" "10" "1" "1.081" "1.046" "1.092" "1.070" "1.074" "1.062" "1.059" "1.055" "1.098" "764.0" "825.5" "798.9" "834.2" "817.4" "820.5" "811.5" "809.3" "806.1" "839.2" "" "" "" "" "" "" "" "" "" "" "613.6" "595.7" "634.6" "558.9" "565.3" "615.6" "568.1" "591.0" "806.1" "682.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5897019344324903703" "False" "High" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "0.000" "False" "42.604" "15" "4" "7" "4" "307" "33.9" "6.29" "28.98" "4" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "0" "1.029" "1.089" "0.853" "0.981" "1.058" "0.912" "1.059" "1.049" "1.031" "594.3" "611.8" "646.9" "506.7" "583.3" "628.7" "542.2" "629.3" "623.5" "612.9" "" "" "" "" "" "" "" "" "" "" "477.4" "441.5" "513.9" "339.5" "403.4" "471.7" "379.6" "459.6" "623.5" "498.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5625477449042213507" "False" "High" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "0.000" "False" "42.576" "30" "7" "11" "7" "222" "24.7" "8.25" "43.78" "7" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "10" "0" "1.042" "1.035" "0.992" "1.048" "0.968" "0.991" "1.054" "1.082" "1.015" "1325.0" "1380.3" "1371.3" "1314.3" "1388.8" "1282.7" "1312.8" "1397.0" "1434.2" "1345.1" "" "" "" "" "" "" "" "" "" "" "1064.2" "996.0" "1089.2" "880.6" "960.5" "962.4" "919.2" "1020.2" "1434.2" "1093.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-105519067553436175" "False" "High" "IsMasterProtein" "Q04323" "UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2" "0.000" "False" "42.505" "37" "7" "11" "7" "297" "33.3" "5.25" "40.65" "7" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00627, Pf00789" "51035" "ENSG00000162191" "UBXN1" "hsa:51035; Q04323; Q9BV93; Q9BVV5" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "2" "0" "1.153" "1.100" "1.206" "1.101" "1.064" "1.091" "1.023" "1.053" "1.119" "702.2" "809.7" "772.6" "846.8" "773.1" "747.1" "766.1" "718.6" "739.7" "786.1" "" "" "" "" "" "" "" "" "" "" "564.0" "584.3" "613.7" "567.3" "534.7" "560.5" "536.4" "524.8" "739.7" "639.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286201540320348411" "False" "High" "IsMasterProtein" "Q92990" "Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2" "0.000" "False" "42.480" "18" "9" "13" "9" "594" "68.2" "5.33" "32.68" "9" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf08568" "11146" "ENSG00000174842" "GLMN" "hsa:11146; Q5VVC3; Q92990; Q9BVE8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.048" "1.000" "1.002" "0.979" "0.952" "0.945" "1.015" "0.961" "0.955" "933.4" "977.8" "933.1" "935.3" "913.4" "888.8" "882.1" "947.6" "897.0" "891.8" "" "" "" "" "" "" "" "" "" "" "749.7" "705.5" "741.2" "626.7" "631.7" "666.9" "617.6" "692.0" "897.0" "725.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285905538601848760" "False" "High" "IsMasterProtein" "Q9H0E9" "Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2" "0.000" "False" "42.479" "7" "8" "11" "8" "1235" "135.3" "4.60" "37.93" "8" "cell organization and biogenesis;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00439" "10902" "ENSG00000112983" "BRD8" "hsa:10902; O43178; Q15355; Q58AB0; Q59GN0; Q969M9; Q9H0E9" "HATs acetylate histones" "" "1" "0" "0.988" "0.957" "0.993" "0.937" "0.941" "0.945" "0.888" "0.889" "0.917" "658.6" "650.9" "630.4" "653.8" "616.9" "619.5" "622.1" "584.9" "585.4" "604.2" "" "" "" "" "" "" "" "" "" "" "529.0" "469.7" "500.8" "438.0" "426.7" "464.8" "435.5" "427.2" "585.4" "491.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7722178459817833286" "False" "High" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "0.000" "False" "42.478" "51" "4" "14" "4" "127" "14.5" "5.38" "45.34" "4" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "0" "0.965" "0.935" "0.959" "0.911" "0.947" "0.928" "0.896" "0.871" "0.920" "992.7" "957.6" "928.2" "952.1" "904.5" "940.2" "921.6" "889.2" "864.5" "913.6" "" "" "" "" "" "" "" "" "" "" "797.3" "691.0" "737.3" "637.9" "625.6" "705.4" "645.2" "649.4" "864.5" "742.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "677526654360538548" "False" "High" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "0.000" "False" "42.432" "26" "7" "26" "6" "375" "42.8" "4.69" "66.01" "7" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "0" "1.042" "1.070" "1.104" "1.006" "0.991" "1.098" "1.052" "1.103" "1.023" "1003.6" "1045.9" "1074.3" "1108.4" "1009.2" "994.5" "1101.8" "1055.9" "1107.1" "1026.6" "" "" "" "" "" "" "" "" "" "" "806.1" "754.7" "853.3" "742.7" "698.0" "746.1" "771.4" "771.1" "1107.1" "834.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6062683060595135562" "False" "High" "IsMasterProtein" "Q9NVE7" "4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1" "0.000" "False" "42.410" "13" "8" "9" "8" "773" "85.9" "6.28" "32.99" "8" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01937, Pf03630" "55229" "ENSG00000157881; ENSG00000273494" "PANK4" "B9DI84; hsa:55229; Q53EU3; Q5TA84; Q7RTX3; Q9H3X5; Q9NVE7" "Vitamin B5 (pantothenate) metabolism" "1p36 copy number variation syndrome" "2" "0" "1.031" "1.000" "0.980" "0.998" "0.964" "0.959" "0.951" "0.975" "1.013" "589.5" "607.5" "589.7" "577.8" "588.6" "568.5" "565.1" "560.4" "575.0" "597.4" "" "" "" "" "" "" "" "" "" "" "473.5" "438.4" "468.4" "387.1" "407.1" "426.5" "395.7" "409.3" "575.0" "485.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1018884242771776576" "False" "High" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "0.000" "False" "42.404" "27" "6" "20" "6" "256" "27.7" "7.78" "63.41" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Detoxification of Reactive Oxygen Species" "Selenium micronutrient network" "2" "0" "1.035" "1.100" "1.018" "1.046" "1.035" "0.963" "1.016" "0.981" "1.045" "2162.9" "2237.8" "2379.8" "2202.3" "2261.6" "2238.2" "2083.3" "2197.1" "2121.6" "2260.2" "" "" "" "" "" "" "" "" "" "" "1737.2" "1614.7" "1890.4" "1475.6" "1564.1" "1679.2" "1458.6" "1604.5" "2121.6" "1838.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6232139059952850141" "False" "High" "IsMasterProtein" "O94874" "E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2" "0.000" "False" "42.396" "12" "10" "11" "10" "794" "89.5" "6.79" "35.97" "10" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09743" "23376" "ENSG00000014123" "UFL1" "A0PJ53; B4DJ57; C0H5X5; hsa:23376; O94874; Q8N765; Q9NTQ0" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.968" "0.949" "1.072" "1.133" "1.053" "1.055" "1.090" "1.135" "1.007" "655.6" "634.8" "622.1" "703.1" "743.1" "690.2" "691.6" "714.8" "744.1" "660.2" "" "" "" "" "" "" "" "" "" "" "526.6" "458.1" "494.1" "471.1" "513.9" "517.8" "484.2" "522.0" "744.1" "536.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260610778738387308" "False" "High" "IsMasterProtein" "Q13907" "Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2" "0.000" "False" "42.381" "35" "6" "15" "6" "227" "26.3" "6.34" "44.02" "6" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00293" "3422" "ENSG00000067064" "IDI1" "B4E155; hsa:3422; Q13907; Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Exercise-induced circadian regulation; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "11" "0" "0.952" "0.900" "0.798" "0.859" "0.978" "0.807" "0.874" "0.914" "0.884" "483.3" "460.0" "434.8" "385.7" "414.9" "472.7" "390.2" "422.5" "441.8" "427.0" "" "" "" "" "" "" "" "" "" "" "388.2" "331.9" "345.4" "258.4" "287.0" "354.6" "273.2" "308.6" "441.8" "347.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "683503187076847751" "False" "High" "IsMasterProtein" "Q96AZ6" "Interferon-stimulated gene 20 kDa protein OS=Homo sapiens OX=9606 GN=ISG20 PE=1 SV=2" "0.000" "False" "42.372" "43" "6" "12" "6" "181" "20.4" "8.92" "46.20" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "3669" "ENSG00000172183" "ISG20" "hsa:3669; O00441; O00586; Q96AZ6" "Interferon alpha/beta signaling" "" "1" "0" "0.957" "0.981" "0.993" "1.029" "1.004" "0.943" "0.947" "0.967" "1.027" "1064.1" "1018.2" "1044.0" "1056.2" "1094.5" "1068.2" "1003.3" "1008.1" "1029.3" "1092.9" "" "" "" "" "" "" "" "" "" "" "854.7" "734.7" "829.3" "707.7" "756.9" "801.4" "702.4" "736.2" "1029.3" "888.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "568464796837822948" "False" "High" "IsMasterProtein" "O43823" "A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1" "0.000" "False" "42.356" "17" "10" "14" "10" "692" "76.1" "5.15" "33.82" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "10270" "ENSG00000105127" "AKAP8" "hsa:10270; O43823" "" "G protein signaling pathways" "1" "0" "1.022" "1.022" "0.978" "1.053" "1.040" "0.997" "1.040" "1.129" "1.062" "572.3" "584.7" "585.0" "559.8" "602.4" "595.0" "570.4" "595.0" "646.1" "607.6" "" "" "" "" "" "" "" "" "" "" "459.6" "421.9" "464.7" "375.1" "416.6" "446.4" "399.4" "434.6" "646.1" "494.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4849374493010714997" "False" "High" "IsMasterProtein" "Q92673" "Sortilin-related receptor OS=Homo sapiens OX=9606 GN=SORL1 PE=1 SV=2" "0.000" "False" "42.262" "5" "9" "9" "9" "2214" "248.3" "5.55" "31.45" "9" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00041, Pf00057, Pf00058, Pf15901, Pf15902" "6653" "ENSG00000137642" "SORL1" "B2RNX7; hsa:6653; Q92673; Q92856" "Amyloid fiber formation" "" "1" "0" "1.020" "1.042" "1.144" "1.151" "1.065" "1.186" "0.995" "1.056" "1.118" "512.5" "522.5" "534.0" "586.5" "590.0" "545.5" "607.8" "509.7" "541.3" "573.1" "" "" "" "" "" "" "" "" "" "" "411.6" "377.0" "424.2" "392.9" "408.1" "409.3" "425.5" "372.2" "541.3" "466.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454971752249747449" "False" "High" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "0.000" "False" "42.244" "27" "4" "10" "4" "190" "20.7" "9.54" "38.00" "4" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "1.043" "0.997" "1.089" "1.035" "0.999" "0.982" "0.981" "0.989" "1.084" "577.8" "602.4" "576.1" "629.2" "597.9" "577.4" "567.1" "566.6" "571.5" "626.5" "" "" "" "" "" "" "" "" "" "" "464.1" "434.7" "457.6" "421.6" "413.5" "433.2" "397.1" "413.8" "571.5" "509.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387303708123169852" "False" "High" "IsMasterProtein" "P07602" "Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2" "0.000" "False" "42.224" "13" "7" "12" "7" "524" "58.1" "5.17" "34.70" "7" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02199, Pf03489, Pf05184" "5660" "ENSG00000197746" "PSAP" "hsa:5660; P07292; P07602; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740; Q92741; Q92742" "Neutrophil degranulation; G alpha (i) signalling events; Platelet degranulation ; Peptide ligand-binding receptors; Glycosphingolipid catabolism" "Degradation pathway of sphingolipids, including diseases" "6" "0" "1.215" "1.109" "1.008" "0.999" "1.092" "0.990" "1.031" "1.071" "1.051" "561.3" "681.8" "622.6" "565.6" "560.8" "612.8" "555.8" "578.6" "601.3" "589.8" "" "" "" "" "" "" "" "" "" "" "450.8" "492.0" "494.5" "379.0" "387.9" "459.8" "389.2" "422.5" "601.3" "479.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6207742459099857160" "False" "High" "IsMasterProtein" "Q9UJ41" "Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3" "0.000" "False" "42.210" "18" "8" "9" "8" "491" "56.9" "7.02" "36.41" "8" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01754, Pf02204, Pf18151" "27342" "ENSG00000154710" "RABGEF1" "B4DZM7; hsa:27342; Q3HKR2; Q3HKR3; Q53FG0; Q9UJ41" "RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs" "16p11.2 distal deletion syndrome" "3" "0" "0.988" "0.996" "0.953" "1.003" "0.952" "0.959" "0.970" "0.984" "1.020" "1389.3" "1372.6" "1383.1" "1323.4" "1393.6" "1322.1" "1332.8" "1347.5" "1366.9" "1416.8" "" "" "" "" "" "" "" "" "" "" "1115.9" "990.4" "1098.7" "886.7" "963.8" "991.9" "933.1" "984.1" "1366.9" "1152.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6835034816184829460" "False" "High" "IsMasterProtein" "Q13363" "C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2" "0.000" "False" "42.167" "24" "10" "15" "6" "440" "47.5" "6.77" "48.98" "10" "protein metabolism;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1487" "ENSG00000159692" "CTBP1" "Q13363; Q4W5N3; Q7Z2Q5" "SUMOylation of transcription cofactors; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes; Signaling by TCF7L2 mutants" "Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "14" "4" "1.034" "1.021" "1.037" "1.008" "0.998" "0.964" "1.017" "1.022" "1.032" "1846.6" "1908.8" "1884.5" "1914.1" "1862.0" "1842.4" "1779.5" "1878.1" "1886.7" "1905.3" "" "" "" "" "" "" "" "" "" "" "1483.2" "1377.3" "1496.9" "1282.4" "1287.8" "1382.3" "1245.9" "1371.6" "1886.7" "1549.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4864862303047708944" "False" "High" "IsMasterProtein" "P52630" "Signal transducer and activator of transcription 2 OS=Homo sapiens OX=9606 GN=STAT2 PE=1 SV=1" "0.000" "False" "42.158" "12" "7" "9" "7" "851" "97.9" "5.49" "28.48" "7" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12188, Pf21354" "6773" "ENSG00000170581" "STAT2" "B4DLC7; G3V2M6; hsa:6773; P52630; Q16430; Q16431; Q9UDL4" "Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of IFNA/IFNB signaling; Interleukin-20 family signaling; Evasion by RSV of host interferon responses" "Type III interferon signaling; Adipogenesis; Chemokine signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Interferon type I signaling pathways; Type II interferon signaling" "21" "0" "1.035" "0.995" "1.113" "1.066" "1.040" "1.053" "1.005" "1.037" "1.041" "377.6" "390.8" "375.8" "420.2" "402.4" "392.7" "397.6" "379.6" "391.5" "393.1" "" "" "" "" "" "" "" "" "" "" "303.3" "282.0" "298.5" "281.5" "278.3" "294.7" "278.4" "277.3" "391.5" "319.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1756983135160374971" "False" "High" "IsMasterProtein" "Q8NBJ5" "Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1" "0.000" "False" "42.151" "16" "10" "13" "10" "622" "71.6" "7.31" "37.09" "10" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf01755, Pf13704" "79709" "ENSG00000130309" "COLGALT1" "hsa:79709; Q8NBJ5; Q8NC64" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "1.011" "1.003" "1.099" "1.103" "1.054" "1.090" "1.127" "1.099" "1.031" "725.9" "734.0" "728.2" "797.6" "801.0" "765.1" "791.4" "818.2" "797.7" "748.7" "" "" "" "" "" "" "" "" "" "" "583.0" "529.7" "578.5" "534.4" "554.0" "574.0" "554.1" "597.5" "797.7" "608.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2846560637843554470" "False" "High" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "0.000" "False" "42.149" "26" "6" "15" "6" "308" "34.5" "5.12" "41.96" "6" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.021" "1.048" "1.072" "1.084" "1.056" "1.013" "1.017" "1.110" "1.054" "817.2" "834.5" "856.9" "876.1" "885.8" "863.1" "827.6" "831.2" "906.9" "861.0" "" "" "" "" "" "" "" "" "" "" "656.4" "602.2" "680.6" "587.0" "612.6" "647.6" "579.5" "607.0" "906.9" "700.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649705542655534815" "False" "High" "IsMasterProtein" "Q8N573" "Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2" "0.000" "False" "42.142" "12" "9" "9" "8" "874" "97.9" "5.47" "30.34" "9" "stress response;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01476, Pf07534" "55074" "ENSG00000164830" "OXR1" "A6NK11; A8KA34; B3KXL1; B7Z402; B7Z8N5; D3HIS6; hsa:55074; Q3LIB5; Q6ZVK9; Q8N573; Q8N8V0; Q9H266; Q9NWC7" "" "" "0" "1" "0.972" "0.931" "0.987" "1.032" "0.999" "0.994" "1.096" "1.054" "1.002" "1086.7" "1056.7" "1011.7" "1073.1" "1121.1" "1085.9" "1080.5" "1190.5" "1145.9" "1088.9" "" "" "" "" "" "" "" "" "" "" "872.8" "762.5" "803.6" "719.0" "775.4" "814.8" "756.5" "869.4" "1145.9" "885.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5669236386910036788" "False" "High" "IsMasterProtein" "P46783" "Small ribosomal subunit protein eS10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "0.000" "False" "42.132" "44" "8" "15" "8" "165" "18.9" "10.15" "44.00" "8" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.139" "1.113" "1.331" "1.236" "1.168" "1.221" "1.067" "1.074" "1.196" "234.0" "266.5" "260.4" "311.4" "289.1" "273.3" "285.7" "249.5" "251.3" "279.9" "" "" "" "" "" "" "" "" "" "" "187.9" "192.3" "206.8" "208.7" "199.9" "205.0" "200.0" "182.2" "251.3" "227.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3620399161639766887" "False" "High" "IsMasterProtein" "Q99471" "Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2" "0.000" "False" "42.128" "36" "5" "15" "5" "154" "17.3" "6.33" "44.54" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02996" "5204" "ENSG00000123349; ENSG00000291834" "PFDN5" "A8K9A8; hsa:5204; Q54AA8; Q99471; Q9C083; Q9C084" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.059" "1.083" "1.022" "0.899" "0.992" "1.024" "0.932" "0.950" "0.949" "1498.7" "1587.2" "1622.7" "1531.2" "1347.9" "1487.4" "1534.5" "1396.5" "1424.3" "1422.4" "" "" "" "" "" "" "" "" "" "" "1203.7" "1145.3" "1288.9" "1025.9" "932.2" "1116.0" "1074.4" "1019.9" "1424.3" "1156.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3912553749902594293" "False" "High" "IsMasterProtein" "P15880" "Small ribosomal subunit protein uS5 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "0.000" "False" "42.115" "29" "9" "18" "9" "293" "31.3" "10.24" "53.29" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988; ENSG00000291931" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Regulation of expression of SLITs and ROBOs; Protein methylation; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; RMTs methylate histone arginines; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "22" "0" "0.987" "1.039" "1.016" "0.964" "0.988" "1.019" "1.013" "1.000" "1.002" "1339.9" "1322.6" "1391.5" "1361.7" "1291.4" "1323.6" "1364.9" "1357.0" "1339.8" "1342.0" "" "" "" "" "" "" "" "" "" "" "1076.2" "954.4" "1105.4" "912.3" "893.2" "993.0" "955.6" "991.0" "1339.8" "1091.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827826663467104318" "False" "High" "IsMasterProtein" "Q9UK41" "Vacuolar protein sorting-associated protein 28 homolog OS=Homo sapiens OX=9606 GN=VPS28 PE=1 SV=1" "0.000" "False" "42.108" "33" "5" "8" "5" "221" "25.4" "5.54" "29.76" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03997" "51160" "ENSG00000160948; ENSG00000285339" "VPS28" "hsa:51160; Q86VK0; Q9UK41" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "7q11.23 copy number variation syndrome" "6" "0" "0.997" "0.977" "1.014" "1.037" "0.973" "0.924" "0.954" "0.984" "1.069" "600.5" "599.0" "586.5" "608.9" "622.4" "584.3" "554.6" "572.7" "590.7" "641.7" "" "" "" "" "" "" "" "" "" "" "482.3" "432.2" "465.9" "408.0" "430.5" "438.4" "388.3" "418.3" "590.7" "521.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6964625045538099576" "False" "High" "IsMasterProtein" "Q9H6R7" "WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1" "0.000" "False" "42.104" "16" "10" "12" "10" "721" "79.1" "6.70" "37.70" "10" "cell organization and biogenesis" "" "other molecular function" "Pf15390" "80304" "ENSG00000163026" "WDCP" "D6W532; hsa:80304; Q8IYK0; Q9H6R7; Q9HBP5" "Signaling by ALK fusions and activated point mutants" "Mesodermal commitment pathway" "2" "0" "1.053" "1.032" "0.939" "1.016" "1.055" "0.921" "1.025" "1.093" "1.018" "664.2" "699.7" "685.2" "624.0" "674.9" "700.5" "612.0" "680.5" "725.9" "676.5" "" "" "" "" "" "" "" "" "" "" "533.5" "504.9" "544.2" "418.1" "466.8" "525.6" "428.5" "497.0" "725.9" "550.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340121106600756603" "False" "High" "IsMasterProtein" "Q9UPY3" "Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3" "0.000" "False" "41.991" "6" "10" "11" "10" "1922" "218.5" "5.68" "38.09" "10" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00636, Pf02170, Pf03368, Pf20930, Pf20931, Pf20932" "23405" "ENSG00000100697" "DICER1" "A7E2D3; B3KRG4; E0AD28; hsa:23405; O95943; Q9UPY3; Q9UQ02" "M-decay: degradation of maternal mRNAs by maternally stored factors; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Hypoxia-mediated EMT and stemness; mRNA processing; Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "11" "0" "1.000" "0.916" "1.016" "0.972" "0.968" "0.918" "0.968" "0.965" "0.946" "756.5" "756.5" "692.7" "768.6" "735.7" "732.6" "694.7" "732.4" "730.2" "715.9" "" "" "" "" "" "" "" "" "" "" "607.6" "545.8" "550.3" "515.0" "508.8" "549.7" "486.4" "534.9" "730.2" "582.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3536014580655726636" "False" "High" "IsMasterProtein" "P98170" "E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2" "0.000" "False" "41.969" "20" "9" "10" "9" "497" "56.6" "6.65" "34.77" "9" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00653, Pf13920, Pf21290" "331" "ENSG00000101966" "XIAP" "D3DTF2; hsa:331; P98170; Q9NQ14" "TNFR1-induced NF-kappa-B signaling pathway; Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Regulation of TNFR1 signaling; TNFR1-induced proapoptotic signaling; Regulation of PTEN localization" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Apoptosis; Focal adhesion; Copper homeostasis; NO/cGMP/PKG mediated neuroprotection; Complement system in neuronal development and plasticity" "20" "0" "1.014" "1.005" "1.004" "1.054" "1.033" "1.084" "1.027" "1.064" "1.027" "509.3" "516.2" "511.7" "511.4" "536.9" "526.2" "552.0" "522.8" "541.7" "523.0" "" "" "" "" "" "" "" "" "" "" "409.1" "372.5" "406.5" "342.6" "371.3" "394.8" "386.5" "381.8" "541.7" "425.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013804065466167884" "False" "High" "IsMasterProtein" "Q3B7T1" "Erythroid differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDRF1 PE=1 SV=1" "0.000" "False" "41.910" "11" "12" "13" "12" "1238" "138.4" "6.33" "34.93" "12" "other biological processes" "nucleus" "" "" "26098" "ENSG00000107938" "EDRF1" "B2RC65; hsa:26098; Q3B7T1; Q3KR40; Q4G190; Q5VZQ4; Q8IZ74; Q9Y3W4" "" "" "0" "0" "0.999" "0.989" "1.049" "0.955" "0.961" "1.000" "1.027" "0.998" "1.026" "520.1" "519.6" "514.2" "545.6" "496.8" "499.6" "520.2" "534.4" "519.1" "533.5" "" "" "" "" "" "" "" "" "" "" "417.7" "374.9" "408.5" "365.6" "343.6" "374.9" "364.2" "390.2" "519.1" "433.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928558694847449526" "False" "High" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "0.000" "False" "41.890" "41" "7" "11" "7" "218" "25.0" "4.93" "40.44" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "" "6" "0" "0.966" "1.037" "0.954" "0.988" "0.986" "0.987" "1.035" "0.975" "0.998" "1053.8" "1017.6" "1092.6" "1005.0" "1041.4" "1038.7" "1040.4" "1090.5" "1027.5" "1052.0" "" "" "" "" "" "" "" "" "" "" "846.4" "734.2" "867.9" "673.4" "720.2" "779.3" "728.5" "796.4" "1027.5" "855.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5044889676122240904" "False" "High" "IsMasterProtein" "Q9H270" "Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1" "0.000" "False" "41.873" "11" "11" "14" "11" "941" "107.8" "7.05" "43.45" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00637, Pf12451, Pf13923" "55823" "" "VPS11" "hsa:55823; Q8WY89; Q96EP8; Q9H270; Q9H6D9; Q9HCS6" "SARS-CoV-2 modulates autophagy" "Network map of SARS-CoV-2 signaling pathway" "2" "0" "1.001" "1.018" "0.992" "1.017" "0.965" "0.928" "0.970" "0.982" "0.986" "813.0" "813.7" "827.5" "806.5" "826.6" "784.3" "754.7" "788.9" "798.2" "801.9" "" "" "" "" "" "" "" "" "" "" "653.0" "587.1" "657.3" "540.3" "571.7" "588.4" "528.4" "576.2" "798.2" "652.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753337708247017490" "False" "High" "IsMasterProtein" "Q9H0R6" "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Homo sapiens OX=9606 GN=QRSL1 PE=1 SV=2" "0.000" "False" "41.857" "18" "8" "9" "8" "528" "57.4" "5.68" "33.26" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01425" "55278" "ENSG00000130348" "QRSL1" "hsa:55278; Q5VWJ4; Q9H0R6; Q9HA60; Q9NV19" "" "" "0" "0" "1.008" "0.973" "0.999" "0.979" "0.974" "0.940" "0.949" "1.002" "0.978" "1412.4" "1423.5" "1374.7" "1410.3" "1382.6" "1376.0" "1327.3" "1341.0" "1414.5" "1381.9" "" "" "" "" "" "" "" "" "" "" "1134.4" "1027.1" "1092.0" "944.9" "956.2" "1032.4" "929.3" "979.3" "1414.5" "1123.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1703725255333180782" "False" "High" "IsMasterProtein" "O14530" "Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2" "0.000" "False" "41.849" "46" "10" "17" "10" "226" "26.5" "5.88" "52.08" "10" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00085" "10190" "ENSG00000115514" "TXNDC9" "B2R9G8; D3DVI4; hsa:10190; O14530; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6" "" "" "0" "0" "0.943" "0.962" "0.938" "0.936" "0.937" "0.958" "0.954" "0.921" "0.947" "1582.8" "1492.2" "1522.0" "1483.9" "1481.6" "1483.8" "1516.9" "1509.8" "1458.4" "1498.6" "" "" "" "" "" "" "" "" "" "" "1271.3" "1076.8" "1209.0" "994.2" "1024.7" "1113.3" "1062.1" "1102.6" "1458.4" "1218.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6935074334363071802" "False" "High" "IsMasterProtein" "O00762" "Ubiquitin-conjugating enzyme E2 C OS=Homo sapiens OX=9606 GN=UBE2C PE=1 SV=1" "0.000" "False" "41.823" "34" "5" "9" "5" "179" "19.6" "7.37" "34.12" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "11065" "ENSG00000175063" "UBE2C" "A6NP33; E1P5N7; G3XAB7; hsa:11065; O00762" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Gastric cancer network 1; Gastric cancer network 2" "21" "0" "0.956" "0.996" "0.926" "0.903" "0.989" "0.662" "0.717" "0.774" "0.910" "1180.2" "1128.2" "1175.0" "1092.4" "1065.3" "1167.0" "781.2" "846.1" "913.5" "1074.0" "" "" "" "" "" "" "" "" "" "" "947.9" "814.1" "933.4" "731.9" "736.8" "875.6" "547.0" "617.9" "913.5" "873.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4497117085705849008" "False" "High" "IsMasterProtein" "Q9UHY1" "Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1" "0.000" "False" "41.817" "17" "6" "8" "6" "535" "59.8" "5.08" "27.83" "6" "transport" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "29959" "ENSG00000115216" "NRBP1" "B3KV40; D6W558; hsa:29959; Q53FZ5; Q96SU3; Q9UHY1" "Nuclear Receptor transcription pathway" "" "1" "0" "0.956" "0.968" "0.996" "0.958" "0.932" "1.009" "0.995" "0.901" "0.920" "584.7" "558.9" "565.8" "582.2" "560.3" "545.1" "589.9" "581.9" "526.5" "538.1" "" "" "" "" "" "" "" "" "" "" "469.6" "403.3" "449.4" "390.1" "387.5" "408.9" "413.0" "425.0" "526.5" "437.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5439043522832827691" "False" "High" "IsMasterProtein" "Q8WZA0" "Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1" "0.000" "False" "41.800" "37" "7" "9" "7" "190" "21.5" "4.94" "34.95" "7" "other biological processes" "" "other molecular function" "Pf06384" "84328" "ENSG00000162441" "LZIC" "B2R6F0; B4E2N0; hsa:84328; Q8WZA0; Q96IU1" "" "" "0" "0" "1.035" "0.954" "1.028" "0.929" "1.036" "1.034" "1.007" "1.042" "0.987" "1591.1" "1647.0" "1518.0" "1635.6" "1478.9" "1648.5" "1645.1" "1601.5" "1658.6" "1571.2" "" "" "" "" "" "" "" "" "" "" "1277.9" "1188.4" "1205.8" "1095.9" "1022.8" "1236.8" "1151.8" "1169.5" "1658.6" "1277.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5329658274444496515" "False" "High" "IsMasterProtein" "O95394" "Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1" "0.000" "False" "41.781" "19" "10" "12" "10" "542" "59.8" "6.25" "34.69" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00408, Pf02878, Pf21404, Pf21405" "5238" "ENSG00000013375" "PGM3" "B2RB65; B4DX94; D6RF12; E1P547; E9PF86; hsa:5238; O95394; Q5JWR4; Q96J46; Q9H8G5; Q9NS94; Q9NTT6; Q9UFV5; Q9UIY2" "Synthesis of UDP-N-acetyl-glucosamine" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "3" "0" "0.992" "1.024" "0.865" "0.919" "1.021" "0.866" "0.929" "0.942" "0.982" "944.4" "937.2" "967.5" "816.5" "867.7" "964.6" "817.5" "877.5" "889.5" "927.3" "" "" "" "" "" "" "" "" "" "" "758.5" "676.2" "768.5" "547.1" "600.1" "723.7" "572.3" "640.8" "889.5" "754.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-366099160936262297" "False" "High" "IsMasterProtein" "Q9NQG5" "Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1" "0.000" "False" "41.770" "26" "7" "12" "7" "326" "36.9" "5.97" "41.96" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "58490" "ENSG00000101413" "RPRD1B" "hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5" "RNA polymerase II transcribes snRNA genes" "Modulators of TCR signaling and T cell activation" "2" "0" "1.044" "1.043" "1.028" "1.042" "1.016" "1.076" "1.006" "1.058" "1.026" "609.0" "635.5" "635.0" "626.0" "634.7" "618.7" "655.2" "612.9" "644.2" "625.0" "" "" "" "" "" "" "" "" "" "" "489.1" "458.6" "504.4" "419.4" "438.9" "464.2" "458.7" "447.6" "644.2" "508.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414945439185658993" "False" "High" "IsMasterProtein" "P84090" "Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1" "0.000" "False" "41.767" "40" "4" "12" "4" "104" "12.3" "5.92" "39.90" "4" "cell cycle OR cell proliferation;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01133" "2079" "ENSG00000100632" "ERH" "B2R5H2; hsa:2079; P70659; P84090; Q14259" "" "" "0" "0" "1.047" "1.093" "0.959" "1.090" "1.133" "1.074" "1.136" "1.168" "1.071" "1382.9" "1447.6" "1512.2" "1326.1" "1507.6" "1566.5" "1485.5" "1571.5" "1615.0" "1481.7" "" "" "" "" "" "" "" "" "" "" "1110.8" "1044.5" "1201.2" "888.5" "1042.7" "1175.4" "1040.1" "1147.7" "1615.0" "1205.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3097608289690062130" "False" "High" "IsMasterProtein" "P43250" "G protein-coupled receptor kinase 6 OS=Homo sapiens OX=9606 GN=GRK6 PE=1 SV=2" "0.000" "False" "41.749" "16" "7" "9" "6" "576" "65.9" "8.00" "30.48" "7" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00615" "2870" "ENSG00000198055" "GRK6" "hsa:2870; O60541; P43250; Q13652" "G alpha (s) signalling events" "Follicle stimulating hormone (FSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Calcium regulation in cardiac cells; 5q35 copy number variation" "7" "0" "1.065" "0.983" "1.051" "1.038" "1.091" "1.029" "1.006" "1.009" "1.107" "363.7" "387.4" "357.5" "382.4" "377.7" "396.7" "374.4" "365.7" "367.1" "402.6" "" "" "" "" "" "" "" "" "" "" "292.1" "279.5" "283.9" "256.2" "261.2" "297.6" "262.1" "267.1" "367.1" "327.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "499510966834701259" "False" "High" "IsMasterProtein" "Q96GS4" "BLOC-1-related complex subunit 6 OS=Homo sapiens OX=9606 GN=BORCS6 PE=1 SV=2" "0.000" "False" "41.647" "20" "5" "8" "5" "357" "37.2" "5.76" "28.87" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10157" "54785" "ENSG00000196544" "BORCS6" "hsa:54785; Q53HS4; Q96GS4; Q9NXW8" "" "" "0" "0" "1.000" "0.975" "1.082" "1.039" "1.050" "1.012" "0.953" "1.011" "1.044" "520.3" "520.5" "507.3" "563.2" "540.7" "546.4" "526.3" "496.0" "525.9" "543.2" "" "" "" "" "" "" "" "" "" "" "417.9" "375.6" "402.9" "377.3" "374.0" "410.0" "368.5" "362.2" "525.9" "441.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711116662832737595" "False" "High" "IsMasterProtein" "Q53EZ4" "Centrosomal protein of 55 kDa OS=Homo sapiens OX=9606 GN=CEP55 PE=1 SV=3" "0.000" "False" "41.599" "17" "8" "11" "7" "464" "54.1" "7.01" "41.63" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf12180" "55165" "ENSG00000138180" "CEP55" "B2RDG8; D3DR37; hsa:55165; Q32WF5; Q3MV20; Q53EZ4; Q5VY28; Q6N034; Q96H32; Q9NVS7" "" "" "0" "0" "1.005" "0.976" "0.950" "1.012" "0.969" "0.899" "0.975" "1.026" "0.987" "1036.7" "1042.1" "1011.5" "985.2" "1049.3" "1004.2" "931.7" "1010.8" "1063.3" "1023.3" "" "" "" "" "" "" "" "" "" "" "832.7" "751.9" "803.5" "660.1" "725.7" "753.5" "652.3" "738.2" "1063.3" "832.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6825792350743248999" "False" "High" "IsMasterProtein" "P07738" "Bisphosphoglycerate mutase OS=Homo sapiens OX=9606 GN=BPGM PE=1 SV=2" "0.000" "False" "41.589" "42" "9" "11" "9" "259" "30.0" "6.54" "41.21" "9" "other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00300" "669" "ENSG00000172331" "BPGM" "A4D1N9; hsa:669; P07738" "Glycolysis" "IL-18 signaling pathway" "2" "0" "0.964" "0.964" "1.087" "1.020" "0.919" "1.065" "0.976" "0.958" "1.002" "882.8" "851.1" "851.1" "959.3" "900.7" "811.0" "940.0" "861.2" "845.5" "884.2" "" "" "" "" "" "" "" "" "" "" "709.1" "614.2" "676.1" "642.7" "622.9" "608.5" "658.1" "628.9" "845.5" "719.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1038572201038202760" "False" "High" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "0.000" "False" "41.587" "43" "4" "24" "4" "100" "10.7" "9.60" "71.64" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "0.977" "0.981" "1.071" "1.008" "1.085" "1.072" "1.047" "0.969" "0.994" "2033.3" "1986.1" "1994.2" "2177.0" "2049.7" "2206.9" "2179.4" "2129.4" "1969.7" "2020.9" "" "" "" "" "" "" "" "" "" "" "1633.1" "1433.1" "1584.0" "1458.6" "1417.6" "1655.8" "1525.9" "1555.1" "1969.7" "1643.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1086525266732812690" "False" "High" "IsMasterProtein" "Q9Y5P4" "Ceramide transfer protein OS=Homo sapiens OX=9606 GN=CERT1 PE=1 SV=1" "0.000" "False" "41.562" "13" "9" "11" "9" "624" "70.8" "5.48" "33.17" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus" "transporter activity;kinase activity;other molecular function" "Pf00169, Pf01852" "10087" "ENSG00000113163" "CERT1" "A8K7S2; B3KUB7; hsa:10087; Q53YV1; Q53YV2; Q96Q85; Q96Q88; Q9H2S7; Q9H2S8; Q9Y5P4" "" "Sphingolipid pathway" "1" "0" "0.983" "1.030" "1.043" "1.011" "1.032" "1.036" "1.050" "0.991" "1.051" "595.2" "585.2" "613.2" "620.7" "601.8" "614.5" "616.5" "624.8" "589.8" "625.3" "" "" "" "" "" "" "" "" "" "" "478.1" "422.3" "487.1" "415.8" "416.2" "461.0" "431.6" "456.3" "589.8" "508.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951709946097313123" "False" "High" "IsMasterProtein" "P78362" "SRSF protein kinase 2 OS=Homo sapiens OX=9606 GN=SRPK2 PE=1 SV=3" "0.000" "False" "41.560" "13" "8" "11" "5" "688" "77.5" "4.97" "32.40" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6733" "ENSG00000135250" "SRPK2" "A8MVX2; hsa:6733; O75220; O75221; P78362; Q6NUL0; Q6V1X2; Q8IYQ3" "Maturation of nucleoprotein" "mRNA processing" "2" "0" "1.117" "1.020" "1.018" "1.021" "1.104" "0.988" "1.061" "0.944" "0.960" "228.2" "254.8" "232.7" "232.3" "233.0" "251.9" "225.5" "242.0" "215.5" "219.0" "" "" "" "" "" "" "" "" "" "" "183.3" "183.9" "184.8" "155.6" "161.1" "189.0" "157.9" "176.8" "215.5" "178.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912307548831863099" "False" "High" "IsMasterProtein" "P25398" "Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "0.000" "False" "41.546" "46" "5" "11" "5" "132" "14.5" "7.21" "38.76" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.000" "1.110" "1.071" "1.222" "1.190" "1.258" "1.165" "1.119" "1.095" "584.3" "584.3" "648.5" "625.7" "714.0" "695.3" "735.0" "680.7" "653.6" "640.0" "" "" "" "" "" "" "" "" "" "" "469.3" "421.6" "515.2" "419.2" "493.8" "521.7" "514.6" "497.1" "653.6" "520.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5930476095621651501" "False" "High" "IsMasterProtein" "Q15283" "Ras GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=RASA2 PE=1 SV=3" "0.000" "False" "41.495" "12" "10" "10" "10" "850" "96.6" "7.20" "34.22" "10" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "5922" "ENSG00000155903" "RASA2" "A8K7K1; G3V0F9; hsa:5922; O00695; Q15283; Q15284; Q92594; Q99577; Q9UEQ2" "Regulation of RAS by GAPs" "MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation" "5" "0" "1.028" "1.017" "0.992" "1.152" "1.051" "1.238" "1.184" "1.135" "1.206" "192.8" "198.3" "196.1" "191.2" "222.1" "202.7" "238.8" "228.4" "218.9" "232.6" "" "" "" "" "" "" "" "" "" "" "154.9" "143.1" "155.8" "128.1" "153.6" "152.1" "167.2" "166.8" "218.9" "189.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3716051439609727834" "False" "High" "IsMasterProtein" "Q9NW82" "WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1" "0.000" "False" "41.467" "17" "10" "12" "10" "654" "73.2" "6.33" "36.32" "10" "" "nucleus;other cell component" "other molecular function" "Pf00400" "55100" "ENSG00000082068" "WDR70" "hsa:55100; Q9H053; Q9NW82" "mRNA Splicing - Major Pathway" "" "1" "0" "0.993" "1.061" "0.978" "0.989" "0.982" "0.947" "0.974" "0.993" "0.978" "869.0" "863.1" "922.3" "850.2" "859.7" "853.7" "823.0" "846.4" "862.7" "849.7" "" "" "" "" "" "" "" "" "" "" "697.9" "622.8" "732.6" "569.6" "594.6" "640.5" "576.2" "618.1" "862.7" "691.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3087577180827751856" "False" "High" "IsMasterProtein" "Q15172" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1" "0.000" "False" "41.461" "16" "7" "8" "6" "486" "56.2" "6.71" "33.97" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5525" "ENSG00000066027" "PPP2R5A" "B2R6D2; B7Z7L2; D3DT99; hsa:5525; Q15172; Q2NL72; Q5VVB2; Q8TBI9" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "27" "0" "1.054" "1.041" "1.050" "1.028" "1.074" "1.040" "1.091" "1.117" "1.061" "915.8" "965.7" "953.8" "961.8" "941.8" "983.4" "952.4" "999.0" "1023.0" "971.5" "" "" "" "" "" "" "" "" "" "" "735.6" "696.8" "757.6" "644.4" "651.3" "737.8" "666.8" "729.6" "1023.0" "790.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449496976955696731" "False" "High" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "0.000" "False" "41.439" "23" "7" "9" "7" "308" "33.9" "4.84" "30.76" "7" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "NoRC negatively regulates rRNA expression" "" "1" "0" "1.060" "0.992" "0.968" "0.931" "0.931" "0.957" "0.968" "0.917" "0.943" "671.0" "711.6" "665.7" "649.2" "624.9" "624.7" "641.9" "649.6" "615.1" "632.8" "" "" "" "" "" "" "" "" "" "" "538.9" "513.4" "528.8" "434.9" "432.2" "468.7" "449.4" "474.4" "615.1" "514.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4828769571271312822" "False" "High" "IsMasterProtein" "P46108" "Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2" "0.000" "False" "41.384" "27" "7" "9" "7" "304" "33.8" "5.55" "36.61" "7" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00017, Pf00018, Pf07653" "1398" "ENSG00000167193" "CRK" "A8MWE8; B0LPE8; D3DTH6; hsa:1398; P46108; Q96GA9; Q96HJ0" "FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; GDNF signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "31" "0" "0.986" "0.998" "1.061" "1.102" "1.118" "1.086" "1.036" "1.063" "1.068" "695.5" "685.9" "694.5" "738.1" "766.5" "777.5" "755.1" "720.5" "739.0" "742.8" "" "" "" "" "" "" "" "" "" "" "558.6" "494.9" "551.6" "494.5" "530.1" "583.3" "528.7" "526.2" "739.0" "604.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8650406954565681421" "False" "High" "IsMasterProtein" "P48426" "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2" "0.000" "False" "41.370" "21" "8" "13" "4" "406" "46.2" "6.99" "43.29" "8" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "5305" "ENSG00000150867" "PIP4K2A" "B0YJ66; B4DGX2; D3DRV1; hsa:5305; P48426; P53807; Q5VUX3" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton; G13 signaling pathway" "6" "0" "0.985" "1.013" "0.964" "0.975" "1.056" "1.036" "0.986" "0.942" "1.065" "384.7" "378.9" "389.9" "370.9" "375.2" "406.3" "398.6" "379.5" "362.4" "409.6" "" "" "" "" "" "" "" "" "" "" "309.0" "273.4" "309.7" "248.5" "259.5" "304.9" "279.1" "277.2" "362.4" "333.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933841314574218963" "False" "High" "IsMasterProtein" "Q99633" "Pre-mRNA-splicing factor 18 OS=Homo sapiens OX=9606 GN=PRPF18 PE=1 SV=1" "0.000" "False" "41.347" "15" "3" "6" "3" "342" "39.8" "8.15" "24.43" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02840, Pf08799" "8559" "ENSG00000165630" "PRPF18" "hsa:8559; Q5T9P9; Q99633; Q9BUI9" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.889" "1.043" "0.969" "1.015" "0.902" "0.933" "0.943" "0.928" "1.032" "76.0" "67.6" "79.3" "73.6" "77.2" "68.6" "70.9" "71.6" "70.5" "78.5" "" "" "" "" "" "" "" "" "" "" "61.0" "48.8" "63.0" "49.3" "53.4" "51.5" "49.7" "52.3" "70.5" "63.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232907791819213920" "False" "High" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "0.000" "False" "41.340" "24" "4" "8" "4" "205" "22.9" "4.63" "32.13" "4" "" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "Neutrophil degranulation" "" "1" "0" "1.050" "1.038" "0.998" "0.985" "1.042" "1.043" "1.090" "1.028" "1.063" "1048.7" "1101.4" "1088.3" "1046.6" "1032.9" "1092.5" "1093.8" "1142.8" "1077.9" "1115.1" "" "" "" "" "" "" "" "" "" "" "842.3" "794.8" "864.5" "701.2" "714.4" "819.7" "765.8" "834.6" "1077.9" "906.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904580809585735729" "False" "High" "IsMasterProtein" "Q8WXW3" "Progesterone-induced-blocking factor 1 OS=Homo sapiens OX=9606 GN=PIBF1 PE=1 SV=2" "0.000" "False" "41.284" "13" "10" "12" "10" "757" "89.8" "6.02" "35.16" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding" "" "10464" "ENSG00000083535" "PIBF1" "hsa:10464; O95664; Q6U9V2; Q6UG50; Q86V07; Q8WXW3; Q96SF4" "" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies" "3" "0" "0.945" "1.001" "1.008" "1.028" "0.987" "0.924" "0.981" "1.040" "1.035" "657.1" "620.9" "657.9" "662.6" "675.7" "648.5" "606.9" "644.7" "683.6" "679.9" "" "" "" "" "" "" "" "" "" "" "527.8" "448.0" "522.6" "443.9" "467.3" "486.6" "425.0" "470.9" "683.6" "552.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619472182958520531" "False" "High" "IsMasterProtein" "P61960" "Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1" "0.000" "False" "41.231" "68" "4" "12" "4" "85" "9.1" "9.31" "51.32" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf03671" "51569" "ENSG00000120686" "UFM1" "hsa:51569; P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2" "" "" "0" "0" "1.105" "1.130" "1.085" "0.960" "1.116" "1.077" "1.073" "0.974" "1.095" "702.1" "775.6" "793.7" "762.1" "673.8" "783.5" "756.3" "753.6" "683.6" "768.5" "" "" "" "" "" "" "" "" "" "" "563.9" "559.7" "630.4" "510.6" "466.0" "587.8" "529.5" "550.3" "683.6" "625.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857445100061984594" "False" "High" "IsMasterProtein" "Q8WVY7" "Ubiquitin-like domain-containing CTD phosphatase 1 OS=Homo sapiens OX=9606 GN=UBLCP1 PE=1 SV=2" "0.000" "False" "41.179" "31" "9" "17" "9" "318" "36.8" "6.46" "47.21" "9" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00240, Pf03031" "134510" "ENSG00000164332" "UBLCP1" "D3DQJ7; hsa:134510; Q8WVY7; Q96DK5" "" "" "0" "0" "1.057" "1.060" "0.954" "0.972" "1.014" "0.885" "1.011" "0.956" "0.994" "1038.8" "1098.0" "1101.0" "990.6" "1009.7" "1053.1" "919.2" "1050.5" "993.3" "1032.6" "" "" "" "" "" "" "" "" "" "" "834.4" "792.3" "874.6" "663.7" "698.3" "790.1" "643.6" "767.2" "993.3" "839.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2725190465399901470" "False" "High" "IsMasterProtein" "P62829" "Large ribosomal subunit protein uL14 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "0.000" "False" "41.173" "54" "7" "19" "7" "140" "14.9" "10.51" "54.46" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "15" "0" "0.888" "0.986" "0.932" "0.993" "0.999" "1.074" "1.166" "1.028" "0.990" "1328.4" "1179.9" "1309.6" "1238.1" "1319.3" "1326.6" "1427.2" "1548.2" "1365.2" "1315.3" "" "" "" "" "" "" "" "" "" "" "1066.9" "851.4" "1040.3" "829.5" "912.4" "995.3" "999.3" "1130.7" "1365.2" "1069.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8027894993262294813" "False" "High" "IsMasterProtein" "Q13131" "5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4" "0.000" "False" "41.163" "25" "12" "12" "12" "559" "64.0" "8.12" "35.86" "12" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf16579, Pf21147" "5562" "ENSG00000132356" "PRKAA1" "A8MTQ6; B2R7E1; hsa:5562; O00286; Q13131; Q5D0E1; Q86VS1; Q9UNQ4" "Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Thyroxine (thyroid hormone) production; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; mir-124 predicted interactions with cell cycle and differentiation ; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Insulin signaling; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Pleural mesothelioma; Affected pathways in Duchenne muscular dystrophy; ADHD and autism (ASD) linked metabolic pathways and SNP" "36" "0" "1.002" "0.978" "1.033" "1.021" "1.065" "0.957" "1.002" "1.069" "1.027" "756.0" "757.3" "739.6" "781.2" "772.2" "804.8" "723.4" "757.4" "808.2" "776.2" "" "" "" "" "" "" "" "" "" "" "607.2" "546.4" "587.5" "523.4" "534.0" "603.9" "506.5" "553.2" "808.2" "631.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9195295084740601325" "False" "High" "IsMasterProtein" "Q00577" "Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2" "0.000" "False" "41.128" "20" "4" "6" "4" "322" "34.9" "6.44" "26.57" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04845" "5813" "ENSG00000185129" "PURA" "hsa:5813; Q00577" "" "Exercise-induced circadian regulation" "1" "0" "0.994" "0.999" "0.909" "0.985" "1.017" "0.908" "0.959" "0.880" "0.977" "452.6" "449.7" "452.3" "411.4" "445.8" "460.4" "411.0" "433.9" "398.3" "442.2" "" "" "" "" "" "" "" "" "" "" "363.6" "324.5" "359.3" "275.6" "308.3" "345.4" "287.8" "316.9" "398.3" "359.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4589433783542351991" "False" "High" "IsMasterProtein" "Q9NVU0" "DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1" "0.000" "False" "41.081" "11" "6" "8" "6" "708" "79.8" "6.47" "34.53" "6" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "" "Pf04801, Pf19725" "55718" "ENSG00000058600; ENSG00000284282" "POLR3E" "B4DL24; B4DUP6; H3BT11; hsa:55718; Q9BWF7; Q9H8W8; Q9H907; Q9NVU0; Q9P276" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "1.024" "1.012" "1.025" "1.001" "0.933" "0.905" "0.941" "1.064" "0.986" "396.3" "405.8" "401.1" "406.2" "396.7" "369.9" "358.7" "372.8" "421.8" "390.9" "" "" "" "" "" "" "" "" "" "" "318.3" "292.8" "318.6" "272.1" "274.3" "277.5" "251.1" "272.3" "421.8" "317.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8303897606251246511" "False" "High" "IsMasterProtein" "Q96HW7" "Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2" "0.000" "False" "41.073" "10" "7" "10" "7" "963" "108.1" "6.44" "38.73" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13646, Pf20168" "92105" "ENSG00000149262" "INTS4" "hsa:92105; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q96HW7; Q9BRC0" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.044" "1.046" "1.192" "1.133" "1.024" "1.044" "1.102" "1.168" "1.121" "677.5" "707.6" "708.5" "807.8" "767.6" "693.4" "707.6" "746.8" "791.6" "759.3" "" "" "" "" "" "" "" "" "" "" "544.2" "510.6" "562.8" "541.2" "530.9" "520.3" "495.4" "545.4" "791.6" "617.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-646999670011784093" "False" "High" "IsMasterProtein" "Q96S55" "ATPase WRNIP1 OS=Homo sapiens OX=9606 GN=WRNIP1 PE=1 SV=2" "0.000" "False" "41.043" "16" "9" "14" "9" "665" "72.1" "6.10" "48.98" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf12002, Pf16193, Pf18279" "56897" "ENSG00000124535" "WRNIP1" "B2RDB0; hsa:56897; Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q96S55; Q9H681; Q9NRJ6" "" "" "0" "0" "1.068" "1.076" "1.153" "1.045" "1.081" "1.065" "1.072" "1.080" "1.088" "442.5" "472.7" "476.2" "510.1" "462.4" "478.5" "471.2" "474.3" "477.7" "481.3" "" "" "" "" "" "" "" "" "" "" "355.4" "341.1" "378.3" "341.8" "319.8" "359.0" "329.9" "346.4" "477.7" "391.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773776656278812315" "False" "High" "IsMasterProtein" "Q6DN90" "IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=IQSEC1 PE=1 SV=1" "0.000" "False" "41.003" "10" "9" "10" "9" "963" "108.2" "6.93" "31.23" "9" "cell organization and biogenesis;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf16453" "9922" "ENSG00000144711" "IQSEC1" "A0A087WWK8; hsa:9922; O94863; Q6DN90; Q96D85" "" "EGF/EGFR signaling pathway" "1" "0" "1.063" "0.984" "1.105" "0.980" "0.988" "1.053" "1.069" "1.050" "1.021" "774.6" "823.5" "762.4" "856.2" "759.4" "765.5" "815.9" "827.8" "813.3" "791.0" "" "" "" "" "" "" "" "" "" "" "622.2" "594.2" "605.6" "573.6" "525.2" "574.4" "571.3" "604.5" "813.3" "643.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962760823323839829" "False" "High" "IsMasterProtein" "O43681" "ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2" "0.000" "False" "40.977" "28" "7" "9" "7" "348" "38.8" "4.91" "34.79" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf02374" "439" "ENSG00000198356" "GET3" "A6NHP8; A8K740; hsa:439; O43681; Q53FC6; Q92849" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "1.019" "1.005" "1.003" "1.035" "0.933" "1.002" "0.973" "1.001" "0.991" "418.4" "426.3" "420.3" "419.5" "433.1" "390.4" "419.1" "406.9" "418.9" "414.8" "" "" "" "" "" "" "" "" "" "" "336.1" "307.6" "333.9" "281.1" "299.5" "292.9" "293.5" "297.2" "418.9" "337.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5846443296709188562" "False" "High" "IsMasterProtein" "Q9Y248" "DNA replication complex GINS protein PSF2 OS=Homo sapiens OX=9606 GN=GINS2 PE=1 SV=1" "0.000" "False" "40.969" "43" "6" "11" "6" "185" "21.4" "5.44" "32.93" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus" "" "Pf05916" "51659" "ENSG00000131153" "GINS2" "D3DUM5; hsa:51659; Q6IAG9; Q9Y248" "Unwinding of DNA" "" "1" "0" "1.052" "0.999" "0.946" "0.987" "1.006" "0.956" "1.010" "1.018" "0.997" "726.3" "764.2" "725.5" "687.4" "717.0" "730.4" "694.4" "733.8" "739.1" "724.1" "" "" "" "" "" "" "" "" "" "" "583.4" "551.4" "576.3" "460.5" "495.9" "548.0" "486.2" "535.9" "739.1" "588.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2471884395781023228" "False" "High" "IsMasterProtein" "Q9Y5X2" "Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1" "0.000" "False" "40.944" "19" "7" "10" "7" "465" "52.5" "7.39" "34.65" "7" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf19566" "29886" "ENSG00000106266" "SNX8" "A4D207; hsa:29886; Q96I67; Q9Y5X2" "" "" "0" "0" "1.050" "1.019" "1.146" "1.027" "0.983" "1.067" "1.110" "1.015" "1.099" "386.1" "405.5" "393.3" "442.5" "396.6" "379.5" "411.9" "428.4" "392.1" "424.3" "" "" "" "" "" "" "" "" "" "" "310.1" "292.6" "312.4" "296.5" "274.3" "284.7" "288.4" "312.9" "392.1" "345.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740436620154947735" "False" "High" "IsMasterProtein" "Q9BX68" "Adenosine 5'-monophosphoramidase HINT2 OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1" "0.000" "False" "40.897" "32" "4" "6" "4" "163" "17.2" "9.16" "26.60" "4" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01230" "84681" "ENSG00000137133" "HINT2" "hsa:84681; Q5TCW3; Q9BX68" "RHOD GTPase cycle" "" "1" "0" "0.950" "0.990" "1.052" "0.990" "0.968" "0.979" "0.972" "0.950" "0.978" "410.6" "390.1" "406.6" "432.1" "406.4" "397.4" "402.1" "399.2" "390.0" "401.7" "" "" "" "" "" "" "" "" "" "" "329.8" "281.5" "323.0" "289.5" "281.1" "298.1" "281.5" "291.5" "390.0" "326.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2215661484008569262" "False" "High" "IsMasterProtein" "Q9UBW7" "Zinc finger MYM-type protein 2 OS=Homo sapiens OX=9606 GN=ZMYM2 PE=1 SV=1" "0.000" "False" "40.884" "8" "10" "14" "10" "1377" "154.8" "6.34" "39.02" "10" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf06467, Pf12012" "7750" "ENSG00000121741" "ZMYM2" "A6NDG0; A6NI02; hsa:7750; O43212; O43434; O60898; Q5W0Q4; Q5W0T3; Q63HP0; Q8NE39; Q9H0V5; Q9H538; Q9UBW7; Q9UEU2" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "" "3" "0" "0.975" "0.977" "1.052" "1.013" "0.999" "0.998" "1.002" "1.011" "1.036" "937.5" "914.1" "915.8" "985.9" "949.7" "936.4" "935.5" "939.6" "947.8" "971.3" "" "" "" "" "" "" "" "" "" "" "753.0" "659.6" "727.4" "660.5" "656.8" "702.5" "655.0" "686.2" "947.8" "789.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7912852613905627854" "False" "High" "IsMasterProtein" "Q01196" "Runt-related transcription factor 1 OS=Homo sapiens OX=9606 GN=RUNX1 PE=1 SV=3" "0.000" "False" "40.843" "25" "7" "8" "7" "453" "48.7" "9.35" "27.50" "7" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "861" "ENSG00000159216" "RUNX1" "A8MV94; B2RMS4; D3DSG1; hsa:861; O60472; O60473; O76047; O76089; Q01196; Q13081; Q13755; Q13756; Q13757; Q13758; Q13759; Q15341; Q15343; Q16122; Q16284; Q16285; Q16286; Q16346; Q16347; Q92479" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Estrogen-dependent gene expression; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 regulates expression of components of tight junctions; Pre-NOTCH Transcription and Translation; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Organic cation transport; SARS-CoV-1 activates/modulates innate immune responses; Transcriptional regulation of granulopoiesis; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling" "Hematopoietic stem cell differentiation; Dual hijack model of Vif in HIV infection; Orexin receptor pathway; Th17 cell differentiation pathway; Acute myeloid leukemia" "24" "0" "1.107" "1.026" "1.123" "1.128" "1.053" "1.095" "1.031" "1.115" "1.045" "391.2" "432.9" "401.2" "439.5" "441.4" "412.0" "428.3" "403.2" "436.2" "408.8" "" "" "" "" "" "" "" "" "" "" "314.2" "312.4" "318.7" "294.5" "305.3" "309.1" "299.9" "294.5" "436.2" "332.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8148433569690540229" "False" "High" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "0.000" "False" "40.831" "26" "6" "14" "5" "320" "33.6" "7.77" "42.87" "6" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Glutamate and glutamine metabolism" "Metabolic reprogramming in colon cancer" "2" "1" "1.011" "1.024" "1.033" "0.994" "0.969" "0.960" "0.998" "0.989" "0.998" "1176.4" "1189.7" "1204.8" "1214.8" "1169.1" "1140.2" "1129.5" "1173.7" "1163.6" "1174.3" "" "" "" "" "" "" "" "" "" "" "944.8" "858.4" "957.0" "813.9" "808.6" "855.5" "790.8" "857.2" "1163.6" "955.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3677224009341935597" "False" "High" "IsMasterProtein" "P48729" "Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2" "0.000" "False" "40.807" "24" "7" "11" "7" "337" "38.9" "9.57" "34.29" "7" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1452" "ENSG00000113712" "CSNK1A1" "D3DQG0; D3DQG1; hsa:1452; P48729; Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Activation of SMO; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein" "Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Complement system; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development" "32" "0" "0.966" "0.979" "0.975" "1.054" "0.975" "0.971" "0.999" "0.961" "0.977" "987.6" "953.6" "966.9" "962.5" "1040.7" "962.7" "958.9" "986.8" "949.0" "965.2" "" "" "" "" "" "" "" "" "" "" "793.2" "688.1" "768.0" "644.9" "719.8" "722.3" "671.4" "720.6" "949.0" "784.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2136811018986940550" "False" "High" "IsMasterProtein" "Q9NS91" "E3 ubiquitin-protein ligase RAD18 OS=Homo sapiens OX=9606 GN=RAD18 PE=1 SV=2" "0.000" "False" "40.783" "20" "10" "11" "10" "495" "56.2" "7.58" "34.09" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf13923" "56852" "ENSG00000070950" "RAD18" "Q58F55; Q9NRT6; Q9NS91" "Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins" "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "3" "0" "1.015" "1.083" "1.003" "0.984" "1.010" "0.997" "1.083" "1.095" "1.091" "719.5" "730.2" "779.3" "721.4" "707.9" "726.4" "717.5" "779.2" "787.5" "785.2" "" "" "" "" "" "" "" "" "" "" "577.9" "526.9" "619.0" "483.3" "489.6" "545.0" "502.3" "569.1" "787.5" "638.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3054532643706144768" "False" "High" "IsMasterProtein" "Q9H0W9" "Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1" "0.000" "False" "40.768" "27" "7" "11" "7" "315" "35.1" "6.70" "35.66" "7" "" "nucleus" "other molecular function" "Pf08925" "28970" "ENSG00000182919" "C11orf54" "A8K850; hsa:28970; Q6FI88; Q6XYB0; Q96EI3; Q96IX1; Q9H0W9; Q9Y6B4" "" "" "0" "0" "1.005" "0.938" "0.984" "1.025" "0.916" "0.994" "0.892" "0.949" "0.939" "604.1" "607.5" "566.8" "594.8" "619.3" "553.5" "600.7" "539.0" "573.2" "567.1" "" "" "" "" "" "" "" "" "" "" "485.2" "438.3" "450.2" "398.5" "428.3" "415.3" "420.6" "393.7" "573.2" "461.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1619272264168287387" "False" "High" "IsMasterProtein" "Q8WVT3" "Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3" "0.000" "False" "40.741" "12" "7" "10" "7" "735" "79.3" "4.91" "33.54" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf13174, Pf14559" "51112" "ENSG00000171853" "TRAPPC12" "B3KV01; D6W4Y2; hsa:51112; Q8WVT3; Q8WVW1; Q9Y395" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.236" "1.055" "1.130" "1.088" "1.057" "1.086" "1.001" "1.057" "1.039" "629.8" "778.4" "664.3" "711.6" "685.2" "665.5" "683.8" "630.2" "665.7" "654.5" "" "" "" "" "" "" "" "" "" "" "505.9" "561.7" "527.6" "476.8" "473.9" "499.3" "478.8" "460.3" "665.7" "532.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819481250379265452" "False" "High" "IsMasterProtein" "Q5JWF2" "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2" "0.000" "False" "40.725" "9" "8" "11" "7" "1037" "111.0" "5.03" "25.43" "8" "cell adhesion;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2778" "ENSG00000087460" "GNAS" "A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state" "Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling" "29" "1" "0.989" "0.942" "0.976" "1.043" "0.939" "1.030" "1.044" "1.015" "0.984" "632.4" "625.1" "595.5" "617.0" "659.7" "593.7" "651.3" "660.3" "641.7" "622.4" "" "" "" "" "" "" "" "" "" "" "507.9" "451.1" "473.0" "413.4" "456.2" "445.5" "456.0" "482.2" "641.7" "506.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4746768512254432328" "False" "High" "IsMasterProtein" "Q9Y4X5" "E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2" "0.000" "False" "40.705" "11" "6" "9" "6" "557" "64.1" "5.08" "29.20" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf01485, Pf19422, Pf21235" "25820" "ENSG00000166233" "ARIH1" "B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5" "PKR-mediated signaling; ISG15 antiviral mechanism; RSV-host interactions" "" "3" "0" "0.939" "1.019" "0.870" "0.990" "1.031" "0.916" "1.012" "1.068" "1.087" "517.9" "486.4" "527.5" "450.6" "512.8" "533.9" "474.5" "524.2" "553.3" "562.9" "" "" "" "" "" "" "" "" "" "" "416.0" "351.0" "419.0" "301.9" "354.7" "400.6" "332.2" "382.8" "553.3" "457.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174880606405183757" "False" "High" "IsMasterProtein" "P56545" "C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1" "0.000" "False" "40.680" "20" "9" "11" "5" "445" "48.9" "6.95" "37.46" "9" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1488" "ENSG00000175029" "CTBP2" "A8K2X5; D3DRF5; hsa:1488; O43449; P56545; Q5SQP7; Q69YI3; Q86SV0; Q8IY44; Q9H2T8" "Repression of WNT target genes; Signaling by TCF7L2 mutants" "Neural crest differentiation; Notch signaling; Mesodermal commitment pathway; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Pleural mesothelioma" "11" "0" "0.949" "1.017" "0.999" "1.063" "0.974" "0.925" "1.053" "0.998" "1.041" "409.3" "388.4" "416.2" "409.0" "435.0" "398.5" "378.6" "430.9" "408.6" "425.9" "" "" "" "" "" "" "" "" "" "" "328.8" "280.3" "330.6" "274.0" "300.9" "299.0" "265.1" "314.7" "408.6" "346.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1948602544583202968" "False" "High" "IsMasterProtein" "Q13042" "Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2" "0.000" "False" "40.639" "17" "10" "12" "10" "620" "71.6" "5.85" "40.39" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf12895, Pf13424" "8881" "ENSG00000130177" "CDC16" "A2A365; hsa:8881; Q13042; Q5T8C8; Q7Z651; Q96AE6; Q9Y564" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.051" "1.047" "1.090" "1.072" "1.027" "1.082" "1.161" "1.038" "1.027" "416.3" "437.5" "435.7" "453.8" "446.3" "427.6" "450.5" "483.3" "432.1" "427.6" "" "" "" "" "" "" "" "" "" "" "334.3" "315.7" "346.1" "304.0" "308.7" "320.8" "315.4" "352.9" "432.1" "347.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7099090004337322375" "False" "High" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "0.000" "False" "40.621" "57" "4" "16" "2" "89" "10.4" "7.40" "67.27" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "Neutrophil degranulation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "28" "2" "1.000" "1.059" "1.000" "0.958" "1.044" "1.005" "1.019" "1.016" "0.998" "2293.7" "2293.9" "2428.2" "2293.8" "2197.2" "2395.7" "2304.2" "2338.4" "2331.5" "2288.6" "" "" "" "" "" "" "" "" "" "" "1842.3" "1655.2" "1928.8" "1536.9" "1519.6" "1797.4" "1613.3" "1707.7" "2331.5" "1861.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1849398190907063362" "False" "High" "IsMasterProtein" "P35813" "Protein phosphatase 1A OS=Homo sapiens OX=9606 GN=PPM1A PE=1 SV=1" "0.000" "False" "40.531" "25" "8" "15" "7" "382" "42.4" "5.36" "43.04" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5494" "ENSG00000100614" "PPM1A" "B5BU11; hsa:5494; J3KNM0; O75551; P35813" "Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "TGF-beta signaling pathway; MAPK signaling pathway" "4" "0" "0.992" "1.040" "0.897" "0.944" "0.962" "0.878" "0.932" "1.004" "0.995" "936.6" "929.5" "974.3" "840.6" "884.1" "901.0" "822.4" "872.6" "940.1" "932.3" "" "" "" "" "" "" "" "" "" "" "752.3" "670.7" "774.0" "563.2" "611.4" "676.0" "575.8" "637.3" "940.1" "758.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8011732413234136033" "False" "High" "IsMasterProtein" "Q9UJX4" "Anaphase-promoting complex subunit 5 OS=Homo sapiens OX=9606 GN=ANAPC5 PE=1 SV=2" "0.000" "False" "40.526" "17" "10" "10" "10" "755" "85.0" "6.87" "34.93" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf12862, Pf21371" "51433" "ENSG00000089053" "ANAPC5" "E9PFB2; hsa:51433; Q8N4H7; Q9BQD4; Q9UJX4" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.159" "1.115" "1.064" "1.115" "1.149" "1.122" "1.027" "1.218" "1.225" "245.9" "285.0" "274.1" "261.6" "274.2" "282.5" "276.0" "252.5" "299.5" "301.4" "" "" "" "" "" "" "" "" "" "" "197.5" "205.7" "217.7" "175.3" "189.6" "211.9" "193.3" "184.4" "299.5" "245.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8398668130488909755" "False" "High" "IsMasterProtein" "Q9BXL7" "Caspase recruitment domain-containing protein 11 OS=Homo sapiens OX=9606 GN=CARD11 PE=1 SV=3" "0.000" "False" "40.498" "9" "8" "8" "8" "1154" "133.2" "6.09" "29.69" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00619" "84433" "ENSG00000198286" "CARD11" "A4D1Z7; hsa:84433; Q2NKN7; Q548H3; Q9BXL7" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "8" "0" "1.108" "0.974" "0.998" "1.061" "1.025" "0.957" "1.060" "1.034" "1.046" "276.8" "306.7" "269.6" "276.2" "293.7" "283.8" "264.9" "293.4" "286.2" "289.7" "" "" "" "" "" "" "" "" "" "" "222.4" "221.3" "214.2" "185.0" "203.1" "212.9" "185.4" "214.3" "286.2" "235.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7173448255119182363" "False" "High" "IsMasterProtein" "P27635" "Large ribosomal subunit protein uL16 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=5" "0.000" "False" "40.489" "28" "4" "8" "4" "214" "24.6" "10.08" "36.47" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "6134" "ENSG00000147403" "RPL10" "A3KQT0; D3DWW6; hsa:6134; P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination" "Cytoplasmic ribosomal proteins; Primary ovarian insufficiency" "15" "0" "0.959" "0.839" "1.040" "1.010" "0.998" "1.121" "0.992" "0.928" "1.004" "634.8" "608.9" "532.9" "660.2" "641.4" "633.8" "711.9" "629.9" "588.8" "637.5" "" "" "" "" "" "" "" "" "" "" "509.9" "439.3" "423.3" "442.4" "443.6" "475.5" "498.4" "460.0" "588.8" "518.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527974897574347786" "False" "High" "IsMasterProtein" "Q16778" "Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3" "0.000" "False" "40.444" "53" "8" "36" "2" "126" "13.9" "10.32" "112.47" "8" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8349" "ENSG00000184678" "H2BC21" "A3KMC7; A8K110; hsa:8349; Q16778; Q4KMY1; Q5QNX0; Q9UE88" "Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Inhibition of DNA recombination at telomere; HCMV Late Events; HCMV Early Events; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Assembly of the ORC complex at the origin of replication; HATs acetylate histones; Amyloid fiber formation; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "" "44" "6" "1.011" "1.042" "1.193" "1.211" "1.072" "1.223" "1.104" "1.022" "1.098" "2433.5" "2460.7" "2535.5" "2903.7" "2946.1" "2607.9" "2976.4" "2686.4" "2488.1" "2670.9" "" "" "" "" "" "" "" "" "" "" "1954.5" "1775.6" "2014.0" "1945.4" "2037.6" "1956.7" "2083.9" "1961.9" "2488.1" "2172.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926098929249154387" "False" "High" "IsMasterProtein" "Q9NR28" "Diablo IAP-binding mitochondrial protein OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "0.000" "False" "40.435" "39" "10" "12" "10" "239" "27.1" "5.90" "33.97" "10" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "10" "0" "1.119" "1.054" "1.140" "1.101" "1.047" "1.009" "1.042" "1.118" "1.049" "853.1" "954.9" "899.1" "972.7" "939.1" "893.1" "860.5" "888.6" "953.4" "894.8" "" "" "" "" "" "" "" "" "" "" "685.2" "689.0" "714.2" "651.7" "649.5" "670.1" "602.5" "649.0" "953.4" "727.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8862135404577219062" "False" "High" "IsMasterProtein" "Q9UJZ1" "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" "0.000" "False" "40.429" "28" "7" "8" "7" "356" "38.5" "7.39" "25.94" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf01145, Pf16200" "30968" "ENSG00000165283" "STOML2" "B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1" "Processing of SMDT1; Cellular response to mitochondrial stress" "" "2" "0" "0.913" "0.838" "1.004" "0.914" "0.948" "0.987" "1.026" "1.101" "1.058" "316.2" "288.7" "265.0" "317.6" "289.0" "299.7" "312.0" "324.4" "348.1" "334.5" "" "" "" "" "" "" "" "" "" "" "254.0" "208.3" "210.5" "212.8" "199.9" "224.8" "218.5" "236.9" "348.1" "272.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812741614734953835" "False" "High" "IsMasterProtein" "Q7L9L4" "MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3" "0.000" "False" "40.389" "25" "5" "14" "5" "216" "25.1" "6.73" "51.66" "5" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "92597" "ENSG00000173542" "MOB1B" "B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23" "Signaling by Hippo" "Pleural mesothelioma" "2" "0" "1.034" "1.079" "0.968" "1.022" "0.943" "0.976" "1.054" "1.037" "1.009" "821.9" "849.6" "886.7" "795.4" "839.8" "775.3" "802.0" "866.2" "852.2" "829.2" "" "" "" "" "" "" "" "" "" "" "660.1" "613.1" "704.3" "532.9" "580.8" "581.7" "561.5" "632.6" "852.2" "674.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1819125433981479748" "False" "High" "IsMasterProtein" "Q15404" "Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3" "0.000" "False" "40.389" "28" "8" "17" "8" "277" "31.5" "8.65" "46.59" "8" "signal transduction;other biological processes" "cytosol;other cell component" "" "Pf13855" "6251" "ENSG00000148484" "RSU1" "A8KA46; D3DRU3; hsa:6251; Q15404; Q6FI17" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "" "1" "0" "1.015" "0.969" "0.974" "0.955" "0.953" "0.951" "0.967" "1.011" "0.949" "1651.9" "1676.0" "1601.0" "1608.2" "1578.2" "1573.8" "1570.2" "1597.3" "1669.8" "1567.9" "" "" "" "" "" "" "" "" "" "" "1326.8" "1209.4" "1271.8" "1077.5" "1091.5" "1180.8" "1099.4" "1166.5" "1669.8" "1275.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193140464994973163" "False" "High" "IsMasterProtein" "P49711" "Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1" "0.000" "False" "40.384" "13" "8" "11" "8" "727" "82.7" "6.96" "38.81" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10664" "ENSG00000102974" "CTCF" "B5MC38; hsa:10664; P49711; Q53XI7; Q59EL8" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "MECP2 and associated Rett syndrome; Prion disease pathway; Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "1.098" "1.173" "1.025" "0.917" "1.009" "0.878" "1.039" "0.982" "1.040" "836.5" "918.4" "981.5" "857.4" "767.2" "844.3" "734.0" "869.1" "821.6" "869.8" "" "" "" "" "" "" "" "" "" "" "671.9" "662.7" "779.6" "574.5" "530.6" "633.5" "513.9" "634.7" "821.6" "707.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209477172492729631" "False" "High" "IsMasterProtein" "Q9UPN6" "SR-related and CTD-associated factor 8 OS=Homo sapiens OX=9606 GN=SCAF8 PE=1 SV=1" "0.000" "False" "40.380" "10" "11" "13" "11" "1271" "140.4" "8.29" "45.05" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "22828" "ENSG00000213079" "SCAF8" "B7Z888; hsa:22828; Q5TBU6; Q6NSK3; Q9BQN8; Q9BX43; Q9UPN6" "" "" "0" "0" "1.030" "1.005" "1.141" "1.122" "1.082" "1.015" "1.065" "1.041" "1.079" "743.5" "765.9" "747.0" "848.0" "833.9" "804.3" "755.0" "792.1" "773.8" "801.9" "" "" "" "" "" "" "" "" "" "" "597.2" "552.7" "593.4" "568.2" "576.7" "603.4" "528.6" "578.5" "773.8" "652.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622169396848351928" "False" "High" "IsMasterProtein" "Q8NFF5" "FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1" "0.000" "False" "40.369" "18" "10" "13" "10" "587" "65.2" "6.93" "41.11" "10" "other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00994, Pf01507" "80308" "ENSG00000160688" "FLAD1" "hsa:80308; Q8N5J1; Q8N686; Q8NFF5; Q8WU93; Q8WUJ4; Q96CR8; Q99764; Q9HBN6" "Vitamin B2 (riboflavin) metabolism" "Selenium micronutrient network; Folate metabolism" "3" "0" "0.978" "0.962" "1.048" "0.941" "0.942" "0.936" "0.940" "0.986" "0.962" "1201.7" "1175.8" "1156.1" "1259.3" "1130.5" "1132.2" "1124.3" "1129.1" "1185.3" "1156.4" "" "" "" "" "" "" "" "" "" "" "965.2" "848.4" "918.3" "843.7" "781.8" "849.4" "787.2" "824.6" "1185.3" "940.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790868284272412731" "False" "High" "IsMasterProtein" "Q9UDY8" "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 OS=Homo sapiens OX=9606 GN=MALT1 PE=1 SV=1" "0.000" "False" "40.360" "12" "7" "9" "7" "824" "92.2" "5.73" "30.06" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656, Pf13895, Pf13927, Pf18703" "10892" "ENSG00000172175" "MALT1" "hsa:10892; Q9NTB7; Q9UDY8; Q9ULX4" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A/inflammasome pathway" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 22q11.2 copy number variation syndrome; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "10" "0" "1.029" "0.965" "1.054" "1.033" "0.972" "1.002" "0.964" "0.945" "1.079" "356.1" "366.5" "343.5" "375.1" "367.7" "346.0" "356.9" "343.4" "336.5" "384.1" "" "" "" "" "" "" "" "" "" "" "286.0" "264.5" "272.8" "251.3" "254.3" "259.6" "249.9" "250.8" "336.5" "312.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8875331277631851835" "False" "High" "IsMasterProtein" "O75113" "NEDD4-binding protein 1 OS=Homo sapiens OX=9606 GN=N4BP1 PE=1 SV=4" "0.000" "False" "40.351" "12" "6" "7" "6" "896" "100.3" "5.36" "31.22" "6" "stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf11977" "9683" "ENSG00000102921" "N4BP1" "A7MD49; hsa:9683; O75113; Q2YDX1" "Regulation of NF-kappa B signaling" "" "1" "0" "0.974" "0.945" "1.120" "1.107" "1.045" "1.040" "1.027" "1.041" "1.089" "448.1" "436.5" "423.5" "501.9" "496.0" "468.3" "466.2" "460.3" "466.4" "488.1" "" "" "" "" "" "" "" "" "" "" "359.9" "315.0" "336.4" "336.2" "343.0" "351.3" "326.4" "336.1" "466.4" "397.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991774416485678648" "False" "High" "IsMasterProtein" "P51948" "CDK-activating kinase assembly factor MAT1 OS=Homo sapiens OX=9606 GN=MNAT1 PE=1 SV=1" "0.000" "False" "40.349" "27" "6" "9" "6" "309" "35.8" "6.09" "33.58" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf06391, Pf17121" "4331" "ENSG00000020426" "MNAT1" "G3V1U8; hsa:4331; P51948; Q15817; Q6ICQ7" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "38" "0" "1.062" "1.051" "1.004" "1.048" "1.034" "1.044" "1.051" "1.139" "1.095" "584.2" "620.5" "614.1" "586.8" "612.4" "603.9" "609.9" "613.7" "665.2" "639.5" "" "" "" "" "" "" "" "" "" "" "469.2" "447.7" "487.8" "393.1" "423.5" "453.1" "427.1" "448.2" "665.2" "520.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "583939558635172856" "False" "High" "IsMasterProtein" "Q9Y4P1" "Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2" "0.000" "False" "40.322" "15" "4" "9" "4" "393" "44.3" "5.07" "38.98" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03416, Pf20166" "23192" "ENSG00000168397" "ATG4B" "B7WNK2; hsa:23192; Q53NU4; Q6ZUV8; Q8WYM9; Q96K07; Q96K96; Q96SZ1; Q9Y2F2; Q9Y4P1" "Macroautophagy" "2q37 copy number variation syndrome" "2" "0" "1.040" "1.041" "1.014" "1.146" "1.049" "1.023" "1.148" "1.075" "1.004" "340.2" "353.7" "354.0" "345.1" "389.8" "356.9" "348.1" "390.5" "365.8" "341.6" "" "" "" "" "" "" "" "" "" "" "273.3" "255.2" "281.2" "231.2" "269.6" "267.8" "243.7" "285.2" "365.8" "277.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5541233720560719878" "False" "High" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "0.000" "False" "40.309" "42" "9" "12" "9" "227" "26.2" "8.82" "37.25" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "1.192" "1.059" "1.263" "1.574" "1.082" "2.098" "1.734" "2.186" "1.437" "378.7" "451.4" "401.3" "478.4" "596.1" "409.9" "794.7" "656.9" "828.1" "544.2" "" "" "" "" "" "" "" "" "" "" "304.2" "325.7" "318.7" "320.5" "412.3" "307.6" "556.4" "479.7" "828.1" "442.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486166187731566186" "False" "High" "IsMasterProtein" "Q9BV57" "Acireductone dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "0.000" "False" "40.284" "42" "6" "13" "6" "179" "21.5" "5.68" "47.50" "6" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "1.052" "0.985" "0.970" "0.944" "0.992" "0.960" "0.980" "0.897" "1.009" "830.2" "873.8" "817.6" "805.2" "784.1" "824.0" "797.4" "813.4" "744.9" "837.8" "" "" "" "" "" "" "" "" "" "" "666.8" "630.5" "649.4" "539.5" "542.3" "618.2" "558.3" "594.0" "744.9" "681.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3185905528720532686" "False" "High" "IsMasterProtein" "P01903" "HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2" "0.000" "False" "40.259" "26" "5" "11" "4" "254" "28.6" "5.00" "41.11" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00993, Pf07654" "3122" "ENSG00000204287; ENSG00000206308; ENSG00000226260; ENSG00000227993; ENSG00000228987; ENSG00000230726; ENSG00000234794; ENSG00000277263" "HLA-DRA" "A2BET4; hsa:3122; P01903; Q30160; Q6IAZ1; Q861I2; Q9TP70" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "Allograft rejection; PI3K/AKT/mTOR - vitamin D3 signaling; Ebola virus infection in host; Male infertility; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; 11p11.2 copy number variation syndrome" "16" "1" "0.935" "0.869" "0.909" "1.028" "1.039" "1.151" "0.843" "0.984" "0.963" "1229.7" "1150.3" "1068.5" "1117.7" "1264.1" "1277.4" "1415.7" "1036.2" "1210.0" "1184.4" "" "" "" "" "" "" "" "" "" "" "987.7" "830.0" "848.7" "748.9" "874.3" "958.4" "991.2" "756.7" "1210.0" "963.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218333417811039911" "False" "High" "IsMasterProtein" "Q9H299" "SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1" "0.000" "False" "40.253" "48" "6" "13" "6" "93" "10.4" "4.93" "41.92" "6" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04908" "83442" "ENSG00000142669" "SH3BGRL3" "hsa:83442; Q5T122; Q9H299" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.027" "1.025" "1.065" "1.091" "1.063" "1.015" "1.110" "1.107" "1.107" "785.0" "805.9" "804.8" "835.8" "856.8" "834.2" "797.1" "871.6" "868.7" "869.1" "" "" "" "" "" "" "" "" "" "" "630.5" "581.5" "639.2" "560.0" "592.6" "625.9" "558.1" "636.5" "868.7" "706.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821127370945399140" "False" "High" "IsMasterProtein" "Q5JVF3" "PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2" "0.000" "False" "40.239" "27" "11" "12" "11" "399" "46.0" "8.53" "35.89" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01399" "55795" "ENSG00000126226" "PCID2" "A6NK09; hsa:55795; Q3ZCX1; Q5JVF3; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3" "" "" "0" "0" "1.108" "1.128" "1.167" "1.099" "1.085" "1.076" "0.997" "1.028" "1.162" "1144.0" "1267.7" "1290.0" "1334.9" "1257.1" "1241.3" "1231.2" "1141.0" "1175.6" "1328.8" "" "" "" "" "" "" "" "" "" "" "918.8" "914.8" "1024.7" "894.4" "869.4" "931.3" "862.0" "833.2" "1175.6" "1080.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4990507016878311040" "False" "High" "IsMasterProtein" "P42126" "Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1" "0.000" "False" "40.197" "28" "7" "15" "7" "302" "32.8" "8.54" "50.42" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1632" "ENSG00000167969" "ECI1" "A8K512; hsa:1632; P42126; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6" "Mitochondrial protein degradation; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "5" "0" "0.972" "0.950" "1.001" "1.019" "1.020" "0.949" "1.017" "0.994" "0.971" "1042.2" "1012.5" "989.6" "1043.7" "1061.9" "1063.3" "989.3" "1060.0" "1036.3" "1011.5" "" "" "" "" "" "" "" "" "" "" "837.1" "730.6" "786.1" "699.3" "734.4" "797.8" "692.7" "774.1" "1036.3" "822.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2854050072506968056" "False" "High" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "0.000" "False" "40.191" "23" "6" "8" "6" "298" "32.8" "9.57" "28.49" "6" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "Base excision repair; DNA repair pathways, full network" "5" "0" "1.005" "1.024" "1.077" "1.026" "1.002" "1.051" "1.039" "0.988" "1.020" "533.8" "536.2" "546.3" "574.9" "547.4" "534.8" "561.0" "554.6" "527.4" "544.6" "" "" "" "" "" "" "" "" "" "" "428.7" "386.9" "433.9" "385.2" "378.6" "401.3" "392.8" "405.1" "527.4" "442.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337623474681162042" "False" "High" "IsMasterProtein" "P18074" "General transcription and DNA repair factor IIH helicase subunit XPD OS=Homo sapiens OX=9606 GN=ERCC2 PE=1 SV=1" "0.000" "False" "40.183" "13" "9" "10" "9" "760" "86.9" "7.15" "39.85" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf06777, Pf13307" "2068" "ENSG00000104884" "ERCC2" "hsa:2068; P18074; Q2TB78; Q2YDY2; Q7KZU6; Q8N721" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Fluoropyrimidine activity; Eukaryotic transcription initiation; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "36" "0" "1.052" "1.021" "1.104" "1.017" "1.011" "0.998" "1.027" "0.995" "1.029" "731.8" "769.8" "747.4" "807.9" "744.3" "739.8" "730.4" "751.8" "728.1" "753.3" "" "" "" "" "" "" "" "" "" "" "587.7" "555.5" "593.6" "541.3" "514.8" "555.1" "511.4" "549.1" "728.1" "612.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088552440920446999" "False" "High" "IsMasterProtein" "Q9Y570" "Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3" "0.000" "False" "40.181" "23" "8" "12" "8" "386" "42.3" "5.97" "38.17" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12697" "51400" "ENSG00000214517" "PPME1" "B3KMU6; B5MEE7; hsa:51400; J3QT22; Q8WYG8; Q9NVT5; Q9UI18; Q9Y570" "Cyclin A/B1/B2 associated events during G2/M transition" "" "1" "0" "0.996" "0.971" "1.004" "0.966" "0.961" "0.958" "0.960" "0.978" "0.952" "2046.7" "2038.3" "1988.3" "2053.9" "1977.7" "1967.3" "1960.3" "1965.1" "2002.4" "1949.0" "" "" "" "" "" "" "" "" "" "" "1643.9" "1470.8" "1579.4" "1376.1" "1367.8" "1476.0" "1372.5" "1435.1" "2002.4" "1585.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4733081690105890722" "False" "High" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "0.000" "False" "40.175" "14" "11" "11" "11" "822" "91.9" "6.65" "39.10" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "0.968" "0.997" "0.974" "0.925" "0.923" "0.899" "0.964" "0.951" "0.944" "1232.2" "1192.8" "1228.5" "1200.1" "1140.3" "1137.7" "1107.4" "1188.1" "1172.0" "1163.4" "" "" "" "" "" "" "" "" "" "" "989.7" "860.7" "975.8" "804.1" "788.6" "853.6" "775.4" "867.7" "1172.0" "946.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337195466672693139" "False" "High" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "0.000" "False" "40.167" "31" "7" "10" "6" "261" "29.3" "6.70" "37.08" "7" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Pyrimidine salvage" "Fluoropyrimidine activity; Pyrimidine metabolism" "3" "0" "1.038" "0.999" "1.025" "1.057" "1.025" "1.038" "0.967" "0.973" "1.052" "509.2" "528.6" "508.9" "521.7" "538.0" "521.9" "528.4" "492.1" "495.6" "535.9" "" "" "" "" "" "" "" "" "" "" "409.0" "381.4" "404.2" "349.6" "372.1" "391.5" "370.0" "359.4" "495.6" "435.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790717896449630852" "False" "High" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "0.000" "False" "40.156" "7" "7" "8" "7" "1303" "140.2" "6.27" "27.47" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "1.088" "1.149" "1.054" "1.074" "1.014" "0.949" "1.144" "1.044" "1.059" "410.8" "446.7" "472.1" "432.9" "441.0" "416.4" "389.8" "470.0" "428.8" "434.9" "" "" "" "" "" "" "" "" "" "" "329.9" "322.4" "375.0" "290.1" "305.0" "312.4" "272.9" "343.3" "428.8" "353.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3970061411929191167" "False" "High" "IsMasterProtein" "Q96G61" "Diphosphoinositol polyphosphate phosphohydrolase 3-beta OS=Homo sapiens OX=9606 GN=NUDT11 PE=1 SV=1" "0.000" "False" "40.143" "37" "5" "10" "3" "164" "18.5" "5.99" "37.78" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "55190" "ENSG00000196368" "NUDT11" "hsa:55190; Q96G61; Q9NVN0" "Synthesis of pyrophosphates in the cytosol" "" "1" "2" "0.994" "0.935" "0.966" "0.986" "1.008" "0.943" "0.997" "1.006" "0.958" "1039.0" "1032.9" "971.0" "1004.0" "1024.6" "1047.1" "979.8" "1035.6" "1044.9" "995.5" "" "" "" "" "" "" "" "" "" "" "834.5" "745.3" "771.3" "672.7" "708.6" "785.6" "686.0" "756.3" "1044.9" "809.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2243304084648640018" "False" "High" "IsMasterProtein" "P49585" "Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2" "0.000" "False" "40.136" "23" "8" "11" "8" "367" "41.7" "7.25" "32.55" "8" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01467" "5130" "ENSG00000161217" "PCYT1A" "A9LYK9; D3DXB1; hsa:5130; P49585; Q86Y88" "Synthesis of PC" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids; 3q29 copy number variation syndrome; Acetylcholine synthesis" "7" "0" "1.050" "1.105" "1.117" "1.103" "1.088" "1.024" "1.080" "1.044" "1.068" "507.9" "533.0" "561.1" "567.1" "560.4" "552.4" "520.0" "548.6" "530.4" "542.3" "" "" "" "" "" "" "" "" "" "" "407.9" "384.6" "445.7" "379.9" "387.6" "414.5" "364.1" "400.7" "530.4" "441.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3263618484320997085" "False" "High" "IsMasterProtein" "Q9H098" "Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1" "0.000" "False" "40.135" "42" "7" "14" "6" "131" "15.5" "8.29" "44.27" "7" "" "" "" "Pf06625" "83641" "ENSG00000065809" "FAM107B" "A8K1P4; D3DRT2; hsa:83641; Q5T9K7; Q5T9K8; Q6ZSI4; Q9H098" "" "" "0" "0" "0.946" "1.006" "1.051" "1.056" "1.095" "1.087" "1.000" "0.979" "0.987" "1622.4" "1535.5" "1632.3" "1704.6" "1713.7" "1775.9" "1763.3" "1622.5" "1588.5" "1600.6" "" "" "" "" "" "" "" "" "" "" "1303.1" "1108.0" "1296.6" "1142.1" "1185.2" "1332.4" "1234.6" "1184.9" "1588.5" "1301.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982176321518383" "False" "High" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "0.000" "False" "40.074" "38" "6" "7" "6" "193" "21.7" "5.39" "26.37" "6" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "1.047" "1.047" "0.955" "0.954" "1.053" "0.889" "1.002" "0.982" "1.043" "568.9" "595.9" "595.5" "543.4" "542.4" "598.9" "505.6" "570.2" "558.6" "593.1" "" "" "" "" "" "" "" "" "" "" "456.9" "430.0" "473.0" "364.1" "375.1" "449.3" "354.0" "416.4" "558.6" "482.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8339310688111388996" "False" "High" "IsMasterProtein" "Q9HCE5" "N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2" "0.000" "False" "40.021" "21" "8" "8" "8" "456" "52.1" "6.21" "31.03" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "57721" "ENSG00000145388" "METTL14" "A6NIG1; hsa:57721; Q969V2; Q9HCE5" "Processing of Capped Intron-Containing Pre-mRNA" "1p36 copy number variation syndrome" "2" "0" "0.938" "0.931" "0.883" "0.932" "0.943" "0.892" "0.911" "0.920" "0.940" "1265.1" "1186.6" "1177.9" "1117.4" "1179.3" "1193.4" "1128.0" "1152.7" "1164.3" "1189.8" "" "" "" "" "" "" "" "" "" "" "1016.1" "856.2" "935.6" "748.7" "815.6" "895.4" "789.8" "841.8" "1164.3" "967.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765435694013910926" "False" "High" "IsMasterProtein" "Q96Q15" "Serine/threonine-protein kinase SMG1 OS=Homo sapiens OX=9606 GN=SMG1 PE=1 SV=3" "0.000" "False" "39.988" "3" "12" "15" "12" "3661" "410.2" "6.46" "39.07" "12" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02260, Pf15785, Pf17229" "23049" "ENSG00000157106" "SMG1" "hsa:23049; O43305; Q13284; Q8NFX2; Q96Q15; Q96QV0; Q96RW3" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "0.982" "0.963" "1.022" "0.970" "0.962" "0.970" "0.989" "0.980" "1.014" "1046.2" "1027.1" "1007.4" "1068.8" "1014.3" "1006.2" "1015.2" "1034.3" "1024.8" "1060.5" "" "" "" "" "" "" "" "" "" "" "840.3" "741.1" "800.2" "716.1" "701.5" "754.9" "710.8" "755.3" "1024.8" "862.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5874507189654450183" "False" "High" "IsMasterProtein" "P50542" "Peroxisomal targeting signal 1 receptor OS=Homo sapiens OX=9606 GN=PEX5 PE=1 SV=3" "0.000" "False" "39.939" "18" "9" "12" "9" "639" "70.8" "4.54" "33.07" "9" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13181" "5830" "ENSG00000139197; ENSG00000288217" "PEX5" "A8K891; B4DZ45; B7ZAD5; D3DUT8; hsa:5830; P50542; Q15115; Q15266; Q96FN7" "Pexophagy" "1p36 copy number variation syndrome" "2" "0" "1.104" "1.108" "1.108" "1.115" "1.097" "1.037" "1.045" "1.104" "1.160" "672.8" "742.8" "745.2" "745.6" "750.3" "737.9" "698.0" "702.9" "742.5" "780.5" "" "" "" "" "" "" "" "" "" "" "540.4" "536.0" "591.9" "499.5" "518.9" "553.6" "488.7" "513.3" "742.5" "634.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740935786864817136" "False" "High" "IsMasterProtein" "Q9BRX2" "Protein pelota homolog OS=Homo sapiens OX=9606 GN=PELO PE=1 SV=2" "0.000" "False" "39.932" "21" "8" "11" "8" "385" "43.3" "6.34" "32.66" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "Pf03463, Pf03464, Pf03465" "53918" "ENSG00000152684" "PELO" "hsa:53918; Q9BRX2; Q9GZS6; Q9Y306" "" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "1" "0" "0.939" "0.994" "1.049" "0.986" "0.971" "1.074" "0.995" "1.034" "1.003" "647.1" "607.9" "643.0" "678.6" "638.3" "628.2" "694.7" "643.7" "669.0" "649.0" "" "" "" "" "" "" "" "" "" "" "519.7" "438.6" "510.7" "454.6" "441.5" "471.3" "486.4" "470.1" "669.0" "527.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4822956659812595428" "False" "High" "IsMasterProtein" "P17706" "Tyrosine-protein phosphatase non-receptor type 2 OS=Homo sapiens OX=9606 GN=PTPN2 PE=1 SV=2" "0.000" "False" "39.927" "21" "9" "12" "9" "415" "48.4" "8.29" "40.68" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5771" "ENSG00000175354" "PTPN2" "A8K955; A8MXU3; hsa:5771; K7ENG3; P17706; Q96AU5; Q96HR2" "PKR-mediated signaling; Negative regulation of MET activity; Interleukin-37 signaling" "Immune response to tuberculosis; 5q35 copy number variation" "5" "0" "0.985" "0.973" "1.009" "0.959" "0.988" "1.001" "0.951" "1.042" "0.989" "998.1" "982.7" "970.9" "1007.5" "957.1" "986.2" "999.5" "949.3" "1040.2" "987.3" "" "" "" "" "" "" "" "" "" "" "801.7" "709.1" "771.2" "675.0" "661.9" "739.9" "699.8" "693.3" "1040.2" "802.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-585008616192458607" "False" "High" "IsMasterProtein" "Q9H6E5" "Speckle targeted PIP5K1A-regulated poly(A) polymerase OS=Homo sapiens OX=9606 GN=TUT1 PE=1 SV=2" "0.000" "False" "39.897" "13" "7" "7" "7" "874" "93.8" "6.16" "27.85" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf03828, Pf12874" "64852" "ENSG00000149016" "TUT1" "A1A527; A8K995; hsa:64852; Q2NL65; Q7L583; Q9H6E5; Q9H6H7" "" "" "0" "0" "0.979" "1.025" "1.034" "0.924" "1.031" "0.840" "0.824" "0.927" "0.979" "633.0" "620.0" "648.7" "654.5" "585.1" "652.8" "531.8" "521.5" "586.8" "620.0" "" "" "" "" "" "" "" "" "" "" "508.4" "447.4" "515.3" "438.5" "404.7" "489.8" "372.4" "380.9" "586.8" "504.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100353375695918439" "False" "High" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "0.000" "False" "39.884" "40" "4" "9" "4" "127" "14.4" "9.60" "32.28" "4" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "1.075" "1.018" "1.067" "0.976" "1.036" "0.937" "1.003" "0.931" "1.034" "776.2" "834.0" "790.0" "828.0" "757.2" "804.3" "727.2" "778.3" "722.8" "802.7" "" "" "" "" "" "" "" "" "" "" "623.4" "601.8" "627.6" "554.8" "523.7" "603.5" "509.1" "568.4" "722.8" "652.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760728246443025630" "False" "High" "IsMasterProtein" "Q99707" "Methionine synthase OS=Homo sapiens OX=9606 GN=MTR PE=1 SV=2" "0.000" "False" "39.865" "7" "8" "9" "8" "1265" "140.4" "5.58" "26.97" "8" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00809, Pf02310, Pf02574, Pf02607, Pf02965" "4548" "ENSG00000116984" "MTR" "A1L4N8; A9Z1W4; B7ZLW7; B9EGF7; hsa:4548; Q99707; Q99713; Q99723" "RHOH GTPase cycle; Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility; Spina bifida" "19" "0" "1.100" "0.994" "1.191" "1.178" "1.742" "1.203" "1.171" "1.280" "1.385" "566.6" "623.3" "563.1" "674.7" "667.4" "987.2" "681.9" "663.8" "725.5" "784.6" "" "" "" "" "" "" "" "" "" "" "455.1" "449.8" "447.3" "452.1" "461.6" "740.7" "477.4" "484.7" "725.5" "638.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6928651678899214990" "False" "High" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "0.000" "False" "39.863" "9" "8" "8" "8" "953" "106.3" "8.32" "27.49" "8" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "1.009" "0.990" "0.915" "0.904" "1.049" "0.969" "1.112" "1.059" "1.056" "564.3" "569.5" "558.6" "516.3" "510.2" "591.9" "546.6" "627.4" "597.8" "595.9" "" "" "" "" "" "" "" "" "" "" "453.2" "410.9" "443.7" "345.9" "352.9" "444.1" "382.7" "458.2" "597.8" "484.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "123318016964233677" "False" "High" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "0.000" "False" "39.834" "29" "6" "8" "6" "264" "30.2" "7.50" "29.38" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "RHOG GTPase cycle; Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "1.010" "0.978" "1.112" "1.033" "0.930" "1.051" "1.005" "1.050" "1.042" "532.1" "537.3" "520.3" "591.8" "549.6" "494.9" "559.2" "534.5" "558.5" "554.7" "" "" "" "" "" "" "" "" "" "" "427.4" "387.7" "413.3" "396.5" "380.1" "371.3" "391.5" "390.4" "558.5" "451.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7259467159663286133" "False" "High" "IsMasterProtein" "Q9Y5N6" "Origin recognition complex subunit 6 OS=Homo sapiens OX=9606 GN=ORC6 PE=1 SV=1" "0.000" "False" "39.828" "33" "8" "10" "8" "252" "28.1" "8.66" "36.70" "8" "DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05460" "23594" "ENSG00000091651" "ORC6" "B3KN89; hsa:23594; Q9Y5N6" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of the pre-replicative complex; Activation of ATR in response to replication stress; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "0.989" "0.972" "1.021" "1.064" "0.970" "1.005" "1.105" "1.063" "0.975" "1722.6" "1703.8" "1674.4" "1758.0" "1832.1" "1671.4" "1730.6" "1904.3" "1831.7" "1678.9" "" "" "" "" "" "" "" "" "" "" "1383.6" "1229.4" "1330.1" "1177.9" "1267.1" "1254.1" "1211.7" "1390.7" "1831.7" "1365.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7583524308725557668" "False" "High" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "0.000" "False" "39.827" "28" "8" "13" "8" "351" "38.7" "6.09" "47.19" "8" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf07676, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "0.982" "1.013" "0.975" "1.040" "1.000" "1.034" "0.968" "0.943" "1.036" "1711.8" "1680.8" "1734.8" "1669.2" "1780.5" "1711.6" "1769.2" "1657.5" "1614.6" "1772.6" "" "" "" "" "" "" "" "" "" "" "1374.9" "1212.8" "1378.0" "1118.4" "1231.4" "1284.2" "1238.7" "1210.5" "1614.6" "1441.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2780012699029809096" "False" "High" "IsMasterProtein" "Q9H9J2" "Large ribosomal subunit protein mL44 OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "0.000" "False" "39.814" "19" "4" "6" "4" "332" "37.5" "8.40" "29.14" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.039" "0.908" "1.024" "0.954" "0.867" "0.963" "0.933" "0.804" "1.024" "254.8" "264.9" "231.4" "261.0" "243.2" "221.0" "245.4" "237.8" "204.8" "261.0" "" "" "" "" "" "" "" "" "" "" "204.7" "191.1" "183.8" "174.9" "168.2" "165.8" "171.8" "173.7" "204.8" "212.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7008442538818735376" "False" "High" "IsMasterProtein" "Q8N4T8" "3-oxoacyl-[acyl-carrier-protein] reductase OS=Homo sapiens OX=9606 GN=CBR4 PE=1 SV=3" "0.000" "False" "39.802" "37" "7" "7" "7" "237" "25.3" "9.33" "26.19" "7" "cell organization and biogenesis;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf13561" "84869" "ENSG00000145439" "CBR4" "hsa:84869; Q8N4T8; Q8WTW8; Q96K93" "Fatty acyl-CoA biosynthesis" "" "1" "0" "1.043" "1.070" "1.123" "1.083" "1.081" "1.012" "1.020" "1.009" "1.120" "664.2" "692.6" "710.6" "746.1" "719.2" "718.1" "672.2" "677.5" "670.1" "743.9" "" "" "" "" "" "" "" "" "" "" "533.5" "499.8" "564.4" "499.9" "497.4" "538.8" "470.6" "494.8" "670.1" "605.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142056770574276442" "False" "High" "IsMasterProtein" "Q96T58" "Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1" "0.000" "False" "39.709" "3" "9" "9" "9" "3664" "402.0" "7.64" "31.07" "9" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf07744, Pf20808, Pf20809, Pf20810" "23013" "ENSG00000065526" "SPEN" "hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556" "RHOBTB1 GTPase cycle" "Notch signaling pathway" "2" "0" "1.030" "1.040" "1.193" "1.055" "1.060" "1.200" "1.222" "1.146" "1.098" "421.1" "433.7" "438.0" "502.2" "444.1" "446.2" "505.2" "514.4" "482.5" "462.3" "" "" "" "" "" "" "" "" "" "" "338.2" "313.0" "347.9" "336.5" "307.1" "334.8" "353.7" "375.7" "482.5" "376.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047661720353379507" "False" "High" "IsMasterProtein" "Q03426" "Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1" "0.000" "False" "39.692" "20" "7" "13" "7" "396" "42.4" "6.46" "42.76" "7" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544" "4598" "ENSG00000110921" "MVK" "hsa:4598; Q03426" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "0.974" "0.920" "1.045" "0.982" "0.945" "1.042" "0.971" "0.992" "1.023" "866.3" "843.5" "796.7" "905.0" "850.4" "819.0" "902.8" "841.3" "859.6" "886.3" "" "" "" "" "" "" "" "" "" "" "695.8" "608.6" "632.8" "606.3" "588.1" "614.5" "632.1" "614.4" "859.6" "720.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7674938862773320945" "False" "High" "IsMasterProtein" "A3KMH1" "von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2" "0.000" "False" "39.633" "6" "11" "12" "11" "1905" "214.7" "7.40" "34.33" "11" "" "mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07728" "23078" "ENSG00000102763" "VWA8" "A3KMH1; hsa:23078; O60310; Q5JTP6; Q5VW08; Q7Z6I9; Q86YC9; Q8N3E4" "" "" "0" "0" "1.026" "0.980" "1.126" "1.106" "0.993" "1.102" "1.076" "0.945" "1.101" "724.0" "742.6" "709.3" "815.0" "800.7" "718.6" "798.0" "778.7" "684.4" "797.1" "" "" "" "" "" "" "" "" "" "" "581.5" "535.9" "563.4" "546.1" "553.8" "539.1" "558.7" "568.7" "684.4" "648.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4492999109905159377" "False" "High" "IsMasterProtein" "Q15121" "Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2" "0.000" "False" "39.606" "49" "5" "10" "5" "130" "15.0" "5.02" "40.65" "5" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01335" "8682" "ENSG00000162734" "PEA15" "B1AKZ3; hsa:8682; O00511; Q15121" "RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation" "Apoptosis modulation and signaling" "3" "0" "1.025" "1.049" "1.094" "0.965" "0.978" "1.096" "1.107" "1.045" "0.994" "1122.7" "1151.0" "1177.8" "1228.3" "1083.7" "1098.3" "1231.0" "1242.7" "1173.5" "1115.5" "" "" "" "" "" "" "" "" "" "" "901.8" "830.5" "935.6" "823.0" "749.5" "824.0" "861.9" "907.6" "1173.5" "907.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266332044031462775" "False" "High" "IsMasterProtein" "O43324" "Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1" "0.000" "False" "39.594" "34" "7" "15" "7" "174" "19.8" "8.54" "54.33" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00043" "9521" "ENSG00000124802" "EEF1E1" "C9JLK5; hsa:9521; O43324; Q5THS2" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "0.965" "1.028" "0.923" "0.933" "1.011" "0.958" "0.968" "0.971" "0.961" "2082.0" "2009.7" "2140.4" "1921.9" "1941.6" "2105.0" "1994.0" "2016.0" "2021.1" "2001.5" "" "" "" "" "" "" "" "" "" "" "1672.2" "1450.2" "1700.2" "1287.7" "1342.8" "1579.3" "1396.1" "1472.3" "2021.1" "1627.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625862126903742140" "False" "High" "IsMasterProtein" "P48556" "26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2" "0.000" "False" "39.573" "27" "12" "18" "12" "350" "39.6" "9.70" "58.55" "12" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf10075" "5714" "ENSG00000099341" "PSMD8" "B4DX18; hsa:5714; P48556; Q6P1L7" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "64" "0" "0.992" "1.023" "0.962" "0.935" "0.964" "0.904" "0.956" "0.960" "0.988" "2305.6" "2288.0" "2357.8" "2218.9" "2156.6" "2223.1" "2084.8" "2203.5" "2214.2" "2277.4" "" "" "" "" "" "" "" "" "" "" "1851.9" "1650.9" "1872.9" "1486.7" "1491.5" "1667.9" "1459.7" "1609.2" "2214.2" "1852.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6029605810403186632" "False" "High" "IsMasterProtein" "Q14674" "Separin OS=Homo sapiens OX=9606 GN=ESPL1 PE=1 SV=3" "0.000" "False" "39.571" "5" "10" "12" "10" "2120" "233.0" "7.55" "35.60" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03568" "9700" "ENSG00000135476" "ESPL1" "hsa:9700; Q14674" "Separation of Sister Chromatids" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Urotensin-II-mediated signaling pathway" "4" "0" "0.984" "1.244" "0.953" "1.030" "1.039" "0.972" "0.981" "0.998" "0.990" "192.8" "189.7" "239.8" "183.8" "198.6" "200.3" "187.4" "189.2" "192.4" "190.9" "" "" "" "" "" "" "" "" "" "" "154.9" "136.9" "190.5" "123.2" "137.4" "150.3" "131.2" "138.2" "192.4" "155.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551747306859767135" "False" "High" "IsMasterProtein" "Q86XZ4" "Spermatogenesis-associated serine-rich protein 2 OS=Homo sapiens OX=9606 GN=SPATS2 PE=1 SV=1" "0.000" "False" "39.548" "20" "9" "11" "9" "545" "59.5" "8.90" "28.59" "9" "" "cytosol;other cell component" "" "Pf07139" "65244" "ENSG00000123352" "SPATS2" "A8K8G9; hsa:65244; Q86XZ4; Q9H7D4; Q9H8Y7; Q9H8Z8" "" "" "0" "0" "1.048" "1.073" "1.041" "1.085" "1.189" "1.174" "1.143" "1.165" "1.149" "724.7" "759.8" "778.0" "754.7" "786.1" "861.7" "850.7" "828.6" "844.1" "832.7" "" "" "" "" "" "" "" "" "" "" "582.1" "548.2" "618.0" "505.7" "543.7" "646.6" "595.6" "605.1" "844.1" "677.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858959922113811047" "False" "High" "IsMasterProtein" "Q6ZMI0" "Protein phosphatase 1 regulatory subunit 21 OS=Homo sapiens OX=9606 GN=PPP1R21 PE=1 SV=1" "0.000" "False" "39.537" "10" "7" "8" "7" "780" "88.3" "6.84" "31.17" "7" "" "other cytoplasmic organelle" "" "Pf10205, Pf10212, Pf21636" "129285" "ENSG00000162869" "PPP1R21" "B7ZKY5; B7ZKY7; E1B6W7; hsa:129285; Q2TA78; Q6ZMI0; Q6ZMI6; Q8IW83; Q8J029; Q96ES8" "" "" "0" "0" "0.974" "0.997" "1.033" "1.051" "0.990" "0.993" "1.014" "1.039" "0.994" "832.8" "810.8" "830.2" "860.0" "875.0" "824.5" "827.1" "844.5" "865.4" "827.9" "" "" "" "" "" "" "" "" "" "" "668.9" "585.1" "659.4" "576.2" "605.1" "618.6" "579.1" "616.7" "865.4" "673.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-150019997035989311" "False" "High" "IsMasterProtein" "Q96JK2" "DDB1- and CUL4-associated factor 5 OS=Homo sapiens OX=9606 GN=DCAF5 PE=1 SV=2" "0.000" "False" "39.504" "11" "7" "7" "7" "942" "103.9" "5.76" "27.63" "7" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "8816" "ENSG00000139990" "DCAF5" "B2RN31; G3V4J7; hsa:8816; O60559; Q8N3V3; Q8N3V5; Q96JK2" "Neddylation" "" "1" "0" "0.977" "1.047" "1.002" "1.056" "1.095" "1.063" "1.129" "1.244" "1.036" "331.8" "324.2" "347.3" "332.3" "350.2" "363.3" "352.6" "374.5" "412.6" "343.6" "" "" "" "" "" "" "" "" "" "" "266.5" "234.0" "275.9" "222.6" "242.2" "272.6" "246.9" "273.5" "412.6" "279.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551730055028160476" "False" "High" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "0.000" "False" "39.483" "27" "6" "14" "4" "225" "25.5" "9.72" "48.87" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA Splicing - Major Pathway" "mRNA processing; Ciliary landscape" "3" "0" "0.993" "1.032" "1.028" "1.014" "0.957" "1.046" "1.007" "0.993" "0.999" "880.0" "874.3" "908.1" "904.6" "892.3" "842.4" "920.8" "886.6" "873.5" "879.5" "" "" "" "" "" "" "" "" "" "" "706.8" "630.8" "721.3" "606.1" "617.1" "632.0" "644.7" "647.5" "873.5" "715.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7428234003778738305" "False" "High" "IsMasterProtein" "Q9BRT2" "Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1" "0.000" "False" "39.457" "48" "5" "7" "5" "126" "14.9" "7.37" "24.65" "5" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf20180" "84300" "ENSG00000137288" "UQCC2" "B2R4I0; Q9BRT2" "" "Mitochondrial complex III assembly" "1" "0" "1.009" "1.106" "1.066" "1.026" "1.042" "1.056" "1.109" "1.186" "1.020" "422.5" "426.1" "467.3" "450.3" "433.3" "440.4" "446.0" "468.3" "500.9" "431.0" "" "" "" "" "" "" "" "" "" "" "339.3" "307.5" "371.2" "301.7" "299.7" "330.4" "312.3" "342.0" "500.9" "350.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5464068146291938331" "False" "High" "IsMasterProtein" "P49840" "Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2" "0.000" "False" "39.440" "16" "6" "10" "4" "483" "50.9" "8.75" "35.73" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2931" "ENSG00000105723" "GSK3A" "hsa:2931; O14959; P49840" "Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein" "IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation; HDAC6 interactions in the central nervous system" "18" "2" "1.014" "1.012" "0.952" "0.929" "1.007" "0.931" "1.003" "1.072" "0.980" "1068.8" "1084.2" "1081.3" "1017.3" "992.7" "1076.4" "994.9" "1072.5" "1146.0" "1047.2" "" "" "" "" "" "" "" "" "" "" "858.5" "782.3" "858.9" "681.6" "686.6" "807.6" "696.6" "783.2" "1146.0" "851.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3678335116251458371" "False" "High" "IsMasterProtein" "P22670" "MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2" "0.000" "False" "39.435" "12" "8" "9" "8" "979" "104.7" "6.29" "32.43" "8" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf04589" "5989" "ENSG00000132005; ENSG00000288283" "RFX1" "hsa:5989; P22670" "" "Alstrom syndrome" "1" "0" "0.916" "1.063" "0.970" "1.063" "0.973" "0.994" "0.937" "0.933" "0.971" "341.6" "313.0" "363.1" "331.3" "363.3" "332.3" "339.6" "320.0" "318.8" "331.9" "" "" "" "" "" "" "" "" "" "" "274.4" "225.8" "288.4" "222.0" "251.3" "249.3" "237.7" "233.7" "318.8" "269.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3013067335374835843" "False" "High" "IsMasterProtein" "Q13153" "Serine/threonine-protein kinase PAK 1 OS=Homo sapiens OX=9606 GN=PAK1 PE=1 SV=2" "0.000" "False" "39.401" "14" "6" "9" "1" "545" "60.6" "5.76" "30.78" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5058" "ENSG00000149269" "PAK1" "hsa:5058; O75561; Q13153; Q13567; Q32M53; Q32M54; Q86W79" "Generation of second messenger molecules; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; MAPK6/MAPK4 signaling; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; EPHB-mediated forward signaling; Ephrin signaling; G beta:gamma signalling through CDC42; Sema3A PAK dependent Axon repulsion; Signal transduction by L1; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; DSCAM interactions; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Androgen receptor network in prostate cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway; T-cell receptor signaling pathway" "56" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2544930509745837934" "False" "High" "IsMasterProtein" "P81877" "Single-stranded DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=SSBP2 PE=1 SV=2" "0.000" "False" "39.398" "27" "6" "10" "5" "361" "37.8" "6.64" "31.76" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04503" "23635" "ENSG00000145687" "SSBP2" "B2R5W1; B7Z1J2; B7Z2L9; B7Z665; D6RH18; E9PB74; E9PDA8; hsa:23635; P81877; Q8N2Q2; Q9BWW6; Q9Y4T7" "" "" "0" "1" "1.092" "0.972" "1.078" "1.057" "0.992" "1.079" "0.968" "1.004" "0.985" "360.2" "393.5" "350.1" "388.4" "380.9" "357.2" "388.6" "348.5" "361.8" "355.0" "" "" "" "" "" "" "" "" "" "" "289.3" "284.0" "278.1" "260.2" "263.4" "268.0" "272.1" "254.5" "361.8" "288.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076185631256904569" "False" "High" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "0.000" "False" "39.360" "39" "10" "14" "10" "225" "25.7" "9.25" "33.29" "10" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "1.004" "1.001" "1.041" "1.027" "0.987" "1.024" "0.949" "1.006" "1.004" "1858.2" "1865.3" "1859.5" "1933.7" "1907.8" "1834.5" "1902.7" "1763.2" "1869.8" "1865.1" "" "" "" "" "" "" "" "" "" "" "1492.5" "1345.9" "1477.0" "1295.6" "1319.5" "1376.4" "1332.2" "1287.7" "1869.8" "1516.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7145553044462341407" "False" "High" "IsMasterProtein" "Q8NI36" "WD repeat-containing protein 36 OS=Homo sapiens OX=9606 GN=WDR36 PE=1 SV=1" "0.000" "False" "39.349" "9" "7" "10" "7" "951" "105.3" "7.53" "37.63" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf04192, Pf12894" "134430" "" "WDR36" "A2RUS4; hsa:134430; Q68E02; Q8N1Q2; Q8NI36" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.078" "1.097" "1.119" "1.046" "1.147" "1.117" "1.077" "1.129" "1.097" "166.4" "179.4" "182.5" "186.1" "174.1" "190.9" "185.9" "179.3" "187.9" "182.5" "" "" "" "" "" "" "" "" "" "" "133.6" "129.5" "145.0" "124.7" "120.4" "143.2" "130.1" "130.9" "187.9" "148.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-973328225883047536" "False" "High" "IsMasterProtein" "Q8IV48" "3'-5' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=ERI1 PE=1 SV=3" "0.000" "False" "39.319" "20" "7" "11" "7" "349" "40.0" "6.70" "36.09" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00929, Pf02037" "90459" "ENSG00000104626" "ERI1" "A8K4U7; hsa:90459; Q8IV48; Q9NSX3" "Major pathway of rRNA processing in the nucleolus and cytosol" "exRNA mechanism of action and biogenesis; 8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "4" "0" "1.003" "1.048" "1.014" "1.011" "0.968" "1.023" "1.026" "1.005" "0.965" "1176.2" "1180.2" "1232.8" "1192.5" "1189.6" "1138.9" "1203.5" "1206.2" "1181.6" "1135.3" "" "" "" "" "" "" "" "" "" "" "944.7" "851.6" "979.2" "799.0" "822.7" "854.5" "842.6" "880.9" "1181.6" "923.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032092853006601019" "False" "High" "IsMasterProtein" "Q13303" "Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2" "0.000" "False" "39.260" "32" "8" "11" "8" "367" "41.0" "9.00" "39.47" "8" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf00248" "8514" "ENSG00000069424" "KCNAB2" "A0AVM9; A8K1A4; B0AZR7; hsa:8514; O43659; Q13303; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411" "Neutrophil degranulation; Voltage gated Potassium channels" "Metapathway biotransformation Phase I and II" "3" "0" "0.962" "1.025" "0.996" "1.041" "1.030" "1.006" "1.026" "0.962" "1.000" "1080.3" "1039.2" "1107.3" "1076.5" "1124.1" "1112.5" "1087.0" "1108.2" "1039.2" "1080.0" "" "" "" "" "" "" "" "" "" "" "867.7" "749.9" "879.6" "721.2" "777.4" "834.7" "761.0" "809.3" "1039.2" "878.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857038607970442570" "False" "High" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "0.000" "False" "39.246" "27" "9" "18" "9" "314" "34.3" "8.85" "48.61" "9" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Mitochondrial protein degradation; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "12" "0" "1.040" "0.981" "1.053" "1.037" "1.008" "1.065" "1.059" "1.038" "1.031" "1861.0" "1934.5" "1825.1" "1959.6" "1929.9" "1876.7" "1981.0" "1970.1" "1931.5" "1918.2" "" "" "" "" "" "" "" "" "" "" "1494.7" "1395.9" "1449.8" "1312.9" "1334.8" "1408.0" "1387.0" "1438.8" "1931.5" "1560.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4704340040215325088" "False" "High" "IsMasterProtein" "Q9GZN8" "Adipose-secreted signaling protein OS=Homo sapiens OX=9606 GN=ADISSP PE=1 SV=3" "0.000" "False" "39.245" "49" "6" "9" "6" "174" "19.3" "6.84" "29.13" "6" "other metabolic processes;other biological processes" "non-structural extracellular" "other molecular function" "Pf15006" "54976" "ENSG00000101220" "ADISSP" "A8K4J0; D3DVX8; hsa:54976; Q5JX81; Q9GZN8; Q9NWX3" "" "" "0" "0" "1.049" "1.015" "1.039" "1.036" "1.012" "1.119" "1.104" "0.988" "0.991" "476.7" "500.2" "484.0" "495.4" "494.0" "482.4" "533.6" "526.3" "471.1" "472.6" "" "" "" "" "" "" "" "" "" "" "382.9" "360.9" "384.5" "331.9" "341.6" "361.9" "373.6" "384.3" "471.1" "384.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2205363031532401399" "False" "High" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "0.000" "False" "39.240" "35" "6" "9" "6" "222" "23.8" "8.38" "38.20" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "Separation of Sister Chromatids; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "19" "0" "0.966" "0.937" "0.990" "0.975" "0.918" "1.032" "0.964" "1.029" "1.018" "402.9" "389.2" "377.6" "398.8" "392.9" "369.9" "416.0" "388.4" "414.6" "410.1" "" "" "" "" "" "" "" "" "" "" "323.6" "280.9" "299.9" "267.2" "271.8" "277.6" "291.2" "283.6" "414.6" "333.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5474212331785371457" "False" "High" "IsMasterProtein" "Q9P2G3" "Kelch-like protein 14 OS=Homo sapiens OX=9606 GN=KLHL14 PE=1 SV=2" "0.000" "False" "39.225" "12" "7" "9" "7" "628" "70.7" "6.68" "29.75" "7" "" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "57565" "ENSG00000197705" "KLHL14" "A6NNW1; B4DHA0; hsa:57565; Q8WU41; Q9P2G3" "" "" "0" "0" "1.015" "1.008" "1.052" "1.055" "0.994" "0.989" "0.985" "0.962" "1.024" "622.2" "631.6" "627.0" "654.5" "656.7" "618.4" "615.2" "612.8" "598.8" "636.9" "" "" "" "" "" "" "" "" "" "" "499.8" "455.8" "498.0" "438.5" "454.2" "464.0" "430.8" "447.5" "598.8" "518.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2659436389650332532" "False" "High" "IsMasterProtein" "Q8TEQ0" "Sorting nexin-29 OS=Homo sapiens OX=9606 GN=SNX29 PE=1 SV=3" "0.000" "False" "39.218" "14" "9" "12" "6" "813" "91.2" "6.21" "29.68" "9" "" "" "other molecular function" "Pf00787, Pf02759" "92017" "ENSG00000048471" "SNX29" "B5MDW2; hsa:92017; Q8N2X2; Q8TEQ0; Q9HA26" "" "" "0" "2" "1.095" "1.096" "1.110" "1.012" "0.942" "0.982" "0.959" "0.950" "0.977" "1240.1" "1357.4" "1358.9" "1376.9" "1255.3" "1168.3" "1217.9" "1189.1" "1178.4" "1211.5" "" "" "" "" "" "" "" "" "" "" "996.0" "979.4" "1079.4" "922.5" "868.2" "876.6" "852.7" "868.4" "1178.4" "985.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9194827022255966282" "False" "High" "IsMasterProtein" "Q9C0J8" "pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2" "0.000" "False" "39.206" "8" "7" "11" "7" "1336" "145.8" "9.17" "26.00" "7" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf01391" "55339" "ENSG00000136709" "WDR33" "hsa:55339; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9C0J8; Q9NUL1" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA Derived from an Intronless Transcript; Processing of Intronless Pre-mRNAs" "" "5" "0" "1.200" "1.200" "1.186" "1.316" "1.468" "1.045" "1.049" "1.087" "1.138" "37.2" "44.6" "44.6" "44.1" "48.9" "54.6" "38.8" "39.0" "40.4" "42.3" "" "" "" "" "" "" "" "" "" "" "29.9" "32.2" "35.4" "29.5" "33.8" "40.9" "27.2" "28.5" "40.4" "34.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4862457629609710254" "False" "High" "IsMasterProtein" "Q5SW79" "Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1" "0.000" "False" "39.198" "7" "10" "10" "10" "1584" "175.2" "7.11" "31.40" "10" "" "cytosol;cytoskeleton;other cell component" "" "Pf00498, Pf15308" "9859" "ENSG00000143702; ENSG00000276725" "CEP170" "hsa:9859; O75058; Q5SW77; Q5SW78; Q5SW79; Q7LGA9; Q86W31; Q9UQ08; Q9UQ09" "" "Ciliary landscape" "1" "0" "1.077" "1.083" "1.033" "0.972" "1.116" "1.131" "1.133" "1.138" "1.079" "651.0" "701.0" "705.3" "672.6" "633.1" "726.8" "736.1" "737.8" "741.1" "702.4" "" "" "" "" "" "" "" "" "" "" "522.9" "505.8" "560.2" "450.7" "437.9" "545.3" "515.4" "538.8" "741.1" "571.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "860011175530275491" "False" "High" "IsMasterProtein" "Q9H0Q0" "CYFIP-related Rac1 interactor A OS=Homo sapiens OX=9606 GN=CYRIA PE=1 SV=1" "0.000" "False" "39.123" "34" "9" "13" "7" "323" "37.3" "6.01" "38.12" "9" "cell organization and biogenesis" "other membranes" "other molecular function" "Pf07159" "81553" "ENSG00000197872" "CYRIA" "B3KNZ1; hsa:81553; Q53QW2; Q9H0Q0" "" "" "0" "0" "1.186" "1.052" "1.181" "1.196" "1.208" "1.137" "0.993" "1.226" "1.072" "213.5" "253.2" "224.5" "252.2" "255.3" "257.9" "242.7" "212.0" "261.8" "228.8" "" "" "" "" "" "" "" "" "" "" "171.5" "182.7" "178.3" "169.0" "176.6" "193.5" "169.9" "154.8" "261.8" "186.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7578805457300167027" "False" "High" "IsMasterProtein" "Q6WKZ4" "Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3" "0.000" "False" "39.114" "8" "9" "10" "9" "1283" "137.1" "5.43" "36.13" "9" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf09457" "80223" "ENSG00000156675" "RAB11FIP1" "hsa:80223; J3KNP0; Q307T1; Q6AZK4; Q6WKZ2; Q6WKZ4; Q6WKZ6; Q86YV4; Q8TDL1; Q9H642" "" "" "0" "0" "1.009" "0.984" "1.106" "1.056" "0.963" "1.082" "1.090" "1.049" "1.043" "824.7" "832.1" "811.8" "911.8" "871.1" "794.4" "892.3" "898.8" "865.1" "860.3" "" "" "" "" "" "" "" "" "" "" "662.4" "600.4" "644.8" "610.9" "602.4" "596.0" "624.7" "656.4" "865.1" "699.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4577230366185343110" "False" "High" "IsMasterProtein" "Q96GM8" "Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1" "0.000" "False" "39.092" "24" "9" "10" "9" "510" "56.5" "7.18" "25.42" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04857" "114034" "ENSG00000132773" "TOE1" "B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846" "" "" "0" "0" "0.981" "0.877" "1.026" "0.923" "0.975" "1.075" "0.881" "0.934" "0.996" "622.7" "610.6" "546.1" "639.0" "574.5" "607.1" "669.1" "548.4" "581.4" "620.0" "" "" "" "" "" "" "" "" "" "" "500.2" "440.6" "433.8" "428.1" "397.3" "455.5" "468.5" "400.5" "581.4" "504.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026735558710273601" "False" "High" "IsMasterProtein" "P36507" "Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1" "0.000" "False" "39.083" "21" "8" "17" "5" "400" "44.4" "6.55" "53.93" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5605" "ENSG00000126934" "MAP2K2" "hsa:5605; P36507" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "88" "2" "1.010" "1.013" "0.982" "0.973" "0.930" "0.951" "0.933" "0.964" "0.971" "601.3" "607.6" "609.3" "590.5" "584.9" "559.0" "571.9" "560.7" "579.8" "583.9" "" "" "" "" "" "" "" "" "" "" "482.9" "438.4" "484.0" "395.7" "404.5" "419.4" "400.4" "409.5" "579.8" "474.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5967874803311728941" "False" "High" "IsMasterProtein" "Q9UBP0" "Spastin OS=Homo sapiens OX=9606 GN=SPAST PE=1 SV=1" "0.000" "False" "39.078" "20" "11" "12" "11" "616" "67.2" "9.64" "34.83" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862" "6683" "ENSG00000021574" "SPAST" "A7E2A7; hsa:6683; Q9UBP0; Q9UPR9" "Sealing of the nuclear envelope (NE) by ESCRT-III" "" "1" "0" "0.983" "0.892" "0.970" "1.065" "1.028" "0.990" "1.029" "1.109" "1.052" "719.4" "707.4" "641.7" "697.9" "766.2" "739.6" "712.3" "740.1" "797.7" "756.8" "" "" "" "" "" "" "" "" "" "" "577.8" "510.5" "509.7" "467.6" "529.9" "554.9" "498.7" "540.5" "797.7" "615.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2863197479310684416" "False" "High" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "0.000" "False" "39.051" "34" "5" "11" "5" "184" "20.7" "7.99" "39.08" "5" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "1.001" "1.032" "1.050" "0.960" "1.063" "1.042" "1.000" "0.973" "1.081" "892.8" "893.9" "921.4" "937.6" "857.1" "949.3" "930.4" "892.7" "868.9" "964.8" "" "" "" "" "" "" "" "" "" "" "717.1" "645.0" "731.9" "628.2" "592.8" "712.2" "651.4" "652.0" "868.9" "784.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481599324901596636" "False" "High" "IsMasterProtein" "O75391" "Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2" "0.000" "False" "39.030" "23" "4" "6" "4" "227" "26.0" "7.91" "26.25" "4" "" "nucleus" "nucleic acid binding activity" "Pf01424" "9552" "ENSG00000091640" "SPAG7" "hsa:9552; O75391; Q96EU5" "" "" "0" "0" "1.008" "1.027" "0.938" "0.910" "0.986" "0.891" "0.924" "1.003" "0.988" "661.2" "666.6" "679.1" "620.2" "601.7" "651.7" "588.9" "611.3" "663.2" "652.9" "" "" "" "" "" "" "" "" "" "" "531.1" "481.0" "539.5" "415.5" "416.2" "489.0" "412.3" "446.4" "663.2" "531.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739336077855480502" "False" "High" "IsMasterProtein" "Q9NWY4" "Histone PARylation factor 1 OS=Homo sapiens OX=9606 GN=HPF1 PE=1 SV=2" "0.000" "False" "39.029" "24" "7" "8" "7" "346" "39.4" "6.80" "28.79" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10228" "54969" "ENSG00000056050" "HPF1" "hsa:54969; Q9NWY4" "" "" "0" "0" "0.962" "0.952" "1.007" "1.045" "0.922" "0.981" "0.966" "0.976" "0.953" "723.6" "695.9" "689.0" "728.7" "756.0" "667.3" "709.9" "698.7" "706.4" "689.3" "" "" "" "" "" "" "" "" "" "" "581.2" "502.1" "547.3" "488.3" "522.8" "500.7" "497.0" "510.3" "706.4" "560.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2510158146736873084" "False" "High" "IsMasterProtein" "P29084" "Transcription initiation factor IIE subunit beta OS=Homo sapiens OX=9606 GN=GTF2E2 PE=1 SV=1" "0.000" "False" "39.000" "36" "9" "14" "9" "291" "33.0" "9.66" "44.41" "9" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf02186, Pf18121" "2961" "ENSG00000197265" "GTF2E2" "D3DSV2; P29084; Q9H2B9" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA polymerase II transcribes snRNA genes" "Eukaryotic transcription initiation" "10" "0" "1.075" "1.094" "1.024" "1.091" "1.052" "0.985" "1.047" "1.131" "1.053" "1047.7" "1126.5" "1146.5" "1072.8" "1143.0" "1102.4" "1032.1" "1097.0" "1185.0" "1102.7" "" "" "" "" "" "" "" "" "" "" "841.5" "812.9" "910.7" "718.8" "790.5" "827.1" "722.6" "801.1" "1185.0" "896.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634047056467408227" "False" "High" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "0.000" "False" "38.989" "40" "3" "10" "3" "126" "13.9" "10.32" "47.44" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.113" "1.148" "1.120" "1.068" "1.103" "0.973" "1.042" "1.090" "1.089" "658.3" "732.6" "755.8" "737.6" "702.8" "725.9" "640.6" "685.7" "717.3" "716.8" "" "" "" "" "" "" "" "" "" "" "528.7" "528.6" "600.4" "494.2" "486.1" "544.6" "448.5" "500.8" "717.3" "582.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667619497174905717" "False" "High" "IsMasterProtein" "Q96MW1" "Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2" "0.000" "False" "38.947" "38" "7" "10" "7" "224" "25.2" "4.92" "35.32" "7" "" "cytosol" "" "" "124808" "ENSG00000180329" "CCDC43" "C9JVK9; hsa:124808; Q96MW1" "" "" "0" "0" "1.054" "0.986" "1.121" "0.996" "1.023" "1.096" "1.099" "1.035" "1.035" "749.3" "790.1" "738.9" "839.9" "746.2" "766.9" "821.2" "823.6" "775.8" "775.8" "" "" "" "" "" "" "" "" "" "" "601.9" "570.1" "586.9" "562.7" "516.1" "575.4" "575.0" "601.5" "775.8" "630.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6508547570803101910" "False" "High" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "0.000" "False" "38.937" "37" "10" "17" "8" "270" "31.8" "6.55" "49.55" "10" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "" "2" "0" "0.982" "0.983" "0.985" "0.965" "1.005" "0.983" "0.966" "0.946" "0.982" "1551.8" "1523.9" "1525.2" "1529.1" "1497.3" "1559.2" "1524.7" "1499.5" "1467.3" "1523.6" "" "" "" "" "" "" "" "" "" "" "1246.4" "1099.6" "1211.5" "1024.5" "1035.5" "1169.8" "1067.5" "1095.1" "1467.3" "1239.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988344905656775202" "False" "High" "IsMasterProtein" "Q92665" "Small ribosomal subunit protein mS31 OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "0.000" "False" "38.932" "26" "10" "15" "10" "395" "45.3" "9.29" "44.80" "10" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.993" "1.030" "1.064" "1.030" "1.012" "0.912" "1.008" "0.966" "0.994" "1158.5" "1150.2" "1193.2" "1232.6" "1192.8" "1172.1" "1056.3" "1167.4" "1119.3" "1151.3" "" "" "" "" "" "" "" "" "" "" "930.5" "830.0" "947.8" "825.8" "824.9" "879.4" "739.6" "852.5" "1119.3" "936.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3568941862227660384" "False" "High" "IsMasterProtein" "Q9NVP2" "Histone chaperone ASF1B OS=Homo sapiens OX=9606 GN=ASF1B PE=1 SV=1" "0.000" "False" "38.916" "45" "6" "9" "5" "202" "22.4" "4.56" "30.69" "6" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04729" "55723" "ENSG00000105011; ENSG00000288210" "ASF1B" "hsa:55723; Q53G51; Q9NVP2; Q9NVZ0" "" "" "0" "1" "1.068" "1.041" "0.989" "1.091" "0.997" "1.111" "1.276" "1.176" "1.096" "518.6" "553.8" "539.7" "512.7" "565.6" "516.9" "576.4" "662.0" "609.8" "568.4" "" "" "" "" "" "" "" "" "" "" "416.5" "399.6" "428.7" "343.5" "391.2" "387.8" "403.5" "483.4" "609.8" "462.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3338411764392514561" "False" "High" "IsMasterProtein" "P45954" "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1" "0.000" "False" "38.876" "24" "7" "9" "7" "432" "47.5" "6.99" "30.50" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "36" "ENSG00000196177" "ACADSB" "B4DQ51; hsa:36; P45954; Q5SQN6; Q96CX7" "Branched-chain amino acid catabolism; Mitochondrial protein degradation" "Valproic acid pathway" "3" "0" "1.051" "1.027" "0.923" "0.960" "1.000" "0.954" "0.974" "0.968" "1.015" "781.6" "821.4" "802.7" "721.1" "750.1" "782.0" "745.8" "761.1" "756.4" "793.1" "" "" "" "" "" "" "" "" "" "" "627.8" "592.7" "637.6" "483.1" "518.8" "586.7" "522.2" "555.8" "756.4" "645.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3785691322693480288" "False" "High" "IsMasterProtein" "O95834" "Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1" "0.000" "False" "38.837" "13" "8" "9" "8" "649" "70.6" "6.32" "33.27" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "24139" "ENSG00000125746" "EML2" "B7Z3I2; B7Z3Q9; hsa:24139; K7ERL7; O95834; Q59EN8; Q8N5A2; Q9UG50" "" "" "0" "0" "1.049" "0.960" "1.026" "1.024" "0.947" "0.979" "0.949" "0.949" "0.989" "789.1" "827.8" "757.3" "809.9" "808.0" "746.9" "772.4" "749.0" "748.5" "780.5" "" "" "" "" "" "" "" "" "" "" "633.8" "597.3" "601.5" "542.7" "558.8" "560.4" "540.8" "547.0" "748.5" "634.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3647581331953333811" "False" "High" "IsMasterProtein" "Q658Y4" "Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3" "0.000" "False" "38.831" "10" "8" "11" "8" "838" "93.9" "6.39" "35.51" "8" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf14647, Pf14648" "157769" "ENSG00000176853" "FAM91A1" "B6YY23; hsa:157769; Q658T5; Q658Y4; Q8TE89" "RHOH GTPase cycle" "Gastric cancer network 2" "2" "0" "1.041" "0.928" "1.013" "0.999" "1.005" "0.916" "0.988" "0.949" "0.990" "589.0" "613.2" "546.7" "596.6" "588.3" "591.8" "539.6" "581.9" "559.2" "583.1" "" "" "" "" "" "" "" "" "" "" "473.1" "442.4" "434.3" "399.7" "406.9" "444.0" "377.8" "425.0" "559.2" "474.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601999827614054718" "False" "High" "IsMasterProtein" "O95067" "G2/mitotic-specific cyclin-B2 OS=Homo sapiens OX=9606 GN=CCNB2 PE=1 SV=1" "0.000" "False" "38.822" "22" "8" "8" "8" "398" "45.3" "8.90" "29.82" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "9133" "ENSG00000157456" "CCNB2" "B3KM93; hsa:9133; O95067; Q6FI99" "Resolution of Sister Chromatid Cohesion; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response" "17" "0" "1.051" "1.069" "1.063" "1.006" "1.022" "1.057" "1.024" "1.063" "1.056" "1447.9" "1521.6" "1547.9" "1539.5" "1455.9" "1480.1" "1530.6" "1482.0" "1539.2" "1529.0" "" "" "" "" "" "" "" "" "" "" "1163.0" "1097.9" "1229.5" "1031.4" "1006.9" "1110.5" "1071.7" "1082.3" "1539.2" "1243.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459643991948160099" "False" "High" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "0.000" "False" "38.733" "11" "11" "14" "11" "1034" "117.1" "7.87" "44.15" "11" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "0.907" "1.102" "1.013" "0.981" "1.033" "1.155" "1.028" "0.992" "0.996" "1331.8" "1207.6" "1467.2" "1349.0" "1306.6" "1376.2" "1538.2" "1369.6" "1321.5" "1326.4" "" "" "" "" "" "" "" "" "" "" "1069.7" "871.4" "1165.4" "903.8" "903.6" "1032.5" "1077.0" "1000.3" "1321.5" "1078.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915758716299824080" "False" "High" "IsMasterProtein" "Q06787" "Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1" "0.000" "False" "38.725" "14" "9" "10" "6" "632" "71.1" "7.42" "37.79" "9" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16098, Pf17904, Pf18336" "2332" "ENSG00000102081" "FMR1" "A6NNH4; D3DWT0; D3DWT1; D3DWT2; G8JL90; hsa:2332; Q06787; Q16578; Q5PQZ6; Q99054" "" "Ovarian infertility; Serotonin and anxiety; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; Primary ovarian insufficiency" "7" "0" "0.970" "0.988" "1.141" "1.145" "1.181" "1.331" "1.110" "1.159" "1.104" "629.7" "611.1" "622.3" "718.7" "721.0" "743.9" "838.3" "699.2" "729.9" "694.9" "" "" "" "" "" "" "" "" "" "" "505.8" "440.9" "494.3" "481.5" "498.7" "558.1" "587.0" "510.6" "729.9" "565.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8791134701989231462" "False" "High" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "0.000" "False" "38.714" "13" "7" "8" "7" "582" "64.8" "8.46" "27.14" "7" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "6" "0" "0.822" "0.919" "0.904" "0.821" "0.940" "0.857" "0.953" "0.972" "0.862" "185.9" "152.7" "170.9" "168.0" "152.6" "174.7" "159.2" "177.2" "180.7" "160.2" "" "" "" "" "" "" "" "" "" "" "149.3" "110.2" "135.7" "112.5" "105.5" "131.1" "111.5" "129.4" "180.7" "130.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4785395366368004219" "False" "High" "IsMasterProtein" "Q15274" "Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Homo sapiens OX=9606 GN=QPRT PE=1 SV=3" "0.000" "False" "38.703" "22" "6" "10" "6" "297" "30.8" "6.21" "36.83" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01729, Pf02749" "23475" "ENSG00000103485" "QPRT" "hsa:23475; Q15274; Q53XW7; Q96G22; Q9BSG6" "Nicotinate metabolism" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome; Kynurenine pathway and links to cell senescence" "5" "0" "0.997" "1.148" "1.099" "1.099" "1.182" "1.120" "1.080" "1.067" "1.121" "579.1" "577.1" "664.7" "636.7" "636.6" "684.3" "648.8" "625.3" "618.1" "649.3" "" "" "" "" "" "" "" "" "" "" "465.1" "416.4" "528.0" "426.6" "440.2" "513.4" "454.3" "456.7" "618.1" "528.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "222321955828462706" "False" "High" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "0.000" "False" "38.675" "75" "4" "14" "4" "68" "7.4" "7.24" "55.39" "4" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "Copper homeostasis" "3" "0" "1.082" "1.054" "1.025" "0.962" "1.048" "1.054" "1.046" "0.994" "0.995" "2003.1" "2167.4" "2111.5" "2054.1" "1927.4" "2099.6" "2110.4" "2094.6" "1991.2" "1992.5" "" "" "" "" "" "" "" "" "" "" "1608.9" "1563.9" "1677.2" "1376.2" "1333.0" "1575.3" "1477.6" "1529.7" "1991.2" "1620.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "353320057128082956" "False" "High" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "0.000" "False" "38.652" "26" "6" "11" "6" "221" "25.5" "8.65" "36.78" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "1.036" "1.029" "1.060" "1.222" "1.286" "1.200" "1.206" "1.274" "1.206" "945.0" "979.2" "972.1" "1001.6" "1154.7" "1215.7" "1134.1" "1139.3" "1203.8" "1139.6" "" "" "" "" "" "" "" "" "" "" "759.0" "706.6" "772.2" "671.1" "798.6" "912.1" "794.1" "832.0" "1203.8" "926.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1603503262744250251" "False" "High" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C16 PE=1 SV=2" "0.000" "False" "38.644" "51" "6" "21" "6" "103" "11.4" "11.36" "64.87" "6" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Senescence-Associated Secretory Phenotype (SASP); RNA Polymerase I Promoter Opening; SUMOylation of chromatin organization proteins; Processing of DNA double-strand break ends; HCMV Late Events; Amyloid fiber formation; Meiotic synapsis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; Nonhomologous End-Joining (NHEJ); Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling" "52" "0" "1.057" "1.175" "1.072" "1.106" "1.125" "1.045" "1.097" "1.019" "1.101" "1495.1" "1580.0" "1756.4" "1602.6" "1654.1" "1681.6" "1562.7" "1639.5" "1523.6" "1645.9" "" "" "" "" "" "" "" "" "" "" "1200.9" "1140.1" "1395.2" "1073.8" "1144.0" "1261.6" "1094.1" "1197.3" "1523.6" "1338.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3524975929259860741" "False" "High" "IsMasterProtein" "Q86X27" "Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Homo sapiens OX=9606 GN=RALGPS2 PE=1 SV=1" "0.000" "False" "38.626" "19" "10" "14" "10" "583" "65.1" "8.73" "35.94" "10" "signal transduction" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00169, Pf00617" "55103" "ENSG00000116191" "RALGPS2" "B7Z7B1; hsa:55103; Q5T5Z1; Q5VZ67; Q86X27; Q9NW78" "" "" "0" "0" "1.071" "0.977" "0.950" "0.993" "0.906" "0.908" "0.978" "0.923" "0.954" "617.9" "661.8" "603.9" "586.8" "613.7" "560.0" "560.9" "604.4" "570.5" "589.4" "" "" "" "" "" "" "" "" "" "" "496.3" "477.6" "479.7" "393.1" "424.4" "420.1" "392.7" "441.4" "570.5" "479.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1135638411849566769" "False" "High" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "0.000" "False" "38.575" "14" "7" "10" "7" "490" "54.9" "10.13" "34.93" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "1.117" "1.114" "1.139" "1.031" "0.996" "1.060" "1.025" "0.998" "1.012" "1713.6" "1913.8" "1908.4" "1951.6" "1766.4" "1706.9" "1816.9" "1757.2" "1709.5" "1734.8" "" "" "" "" "" "" "" "" "" "" "1376.4" "1380.9" "1515.9" "1307.6" "1221.6" "1280.7" "1272.1" "1283.3" "1709.5" "1410.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7154338873387211180" "False" "High" "IsMasterProtein" "Q8TDQ7" "Glucosamine-6-phosphate isomerase 2 OS=Homo sapiens OX=9606 GN=GNPDA2 PE=1 SV=1" "0.000" "False" "38.548" "30" "6" "8" "6" "276" "31.1" "6.95" "25.57" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01182" "132789" "ENSG00000163281" "GNPDA2" "B4DJF3; hsa:132789; Q2VYF1; Q59EA7; Q8NCZ8; Q8TDQ7; Q96BJ4; Q96NC6" "Glycolysis" "" "1" "0" "0.957" "0.928" "0.991" "1.092" "0.915" "1.077" "0.931" "0.927" "0.992" "360.6" "344.9" "334.5" "357.5" "393.6" "330.0" "388.3" "335.7" "334.4" "357.8" "" "" "" "" "" "" "" "" "" "" "289.6" "248.9" "265.7" "239.5" "272.2" "247.6" "271.9" "245.2" "334.4" "290.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-296072814185556824" "False" "High" "IsMasterProtein" "Q9BUI4" "DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1" "0.000" "False" "38.541" "21" "10" "11" "10" "534" "60.6" "7.31" "34.29" "10" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05645, Pf08221, Pf20912" "10623" "ENSG00000186141" "POLR3C" "hsa:10623; O15317; Q9BUI4; Q9Y3R6" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "10" "0" "0.981" "0.969" "0.969" "0.987" "0.936" "0.958" "0.946" "1.013" "0.939" "1054.7" "1034.6" "1021.8" "1021.8" "1040.6" "987.0" "1010.6" "997.7" "1067.9" "990.2" "" "" "" "" "" "" "" "" "" "" "847.1" "746.6" "811.6" "684.6" "719.7" "740.5" "707.5" "728.7" "1067.9" "805.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-115181160460478952" "False" "High" "IsMasterProtein" "P35754" "Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2" "0.000" "False" "38.535" "30" "2" "7" "2" "106" "11.8" "8.09" "31.36" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00462" "2745" "ENSG00000173221" "GLRX" "B2R4L2; hsa:2745; P35754; Q3KQS1; Q6ICT1" "Interconversion of nucleotide di- and triphosphates" "One-carbon metabolism" "2" "0" "1.074" "1.051" "1.015" "0.895" "0.947" "0.975" "1.006" "0.995" "1.034" "543.1" "583.3" "570.7" "551.3" "486.3" "514.5" "529.4" "546.3" "540.5" "561.3" "" "" "" "" "" "" "" "" "" "" "436.2" "420.9" "453.3" "369.4" "336.4" "386.0" "370.6" "399.0" "540.5" "456.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6548869844035824343" "False" "High" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "0.000" "False" "38.509" "26" "9" "13" "9" "306" "32.4" "9.17" "42.68" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "0.927" "1.045" "0.953" "0.893" "0.937" "0.972" "1.116" "0.983" "1.014" "1683.1" "1560.2" "1759.3" "1604.2" "1503.1" "1577.1" "1635.6" "1877.5" "1654.7" "1706.5" "" "" "" "" "" "" "" "" "" "" "1351.9" "1125.8" "1397.5" "1074.8" "1039.6" "1183.3" "1145.1" "1371.2" "1654.7" "1387.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3430961605673792526" "False" "High" "IsMasterProtein" "Q13033" "Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3" "0.000" "False" "38.481" "11" "6" "7" "6" "797" "87.2" "5.36" "29.08" "6" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400, Pf08232" "29966" "ENSG00000196792" "STRN3" "A2RTX7; A6NHZ7; hsa:29966; Q13033; Q9NRA5" "" "" "0" "0" "1.106" "1.005" "1.033" "1.127" "1.143" "1.128" "1.212" "1.144" "1.077" "526.1" "581.8" "528.7" "543.7" "593.2" "601.4" "593.6" "637.9" "602.0" "566.4" "" "" "" "" "" "" "" "" "" "" "422.6" "419.8" "420.0" "364.3" "410.2" "451.2" "415.6" "465.9" "602.0" "460.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7643769137675685694" "False" "High" "IsMasterProtein" "P82933" "Small ribosomal subunit protein uS9m OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" "0.000" "False" "38.373" "26" "9" "16" "9" "396" "45.8" "9.51" "49.86" "9" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00380" "64965" "ENSG00000135972" "MRPS9" "hsa:64965; P82933; Q6PG40" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.078" "1.052" "1.135" "1.055" "1.021" "0.958" "1.068" "1.007" "1.063" "912.0" "983.1" "959.1" "1035.0" "962.1" "931.0" "873.8" "973.9" "918.5" "969.2" "" "" "" "" "" "" "" "" "" "" "732.5" "709.4" "761.8" "693.5" "665.4" "698.5" "611.8" "711.2" "918.5" "788.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9217624131527771053" "False" "High" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "0.000" "False" "38.368" "18" "10" "12" "10" "501" "54.1" "8.66" "33.14" "10" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "Amino acid metabolism" "5" "0" "0.967" "0.970" "0.967" "0.977" "0.976" "0.928" "0.958" "0.986" "0.978" "1053.1" "1018.5" "1021.2" "1018.2" "1028.7" "1028.0" "977.8" "1008.5" "1038.7" "1029.6" "" "" "" "" "" "" "" "" "" "" "845.9" "734.9" "811.2" "682.2" "711.5" "771.3" "684.6" "736.5" "1038.7" "837.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7933868971006090466" "False" "High" "IsMasterProtein" "Q8WUH2" "Transforming growth factor-beta receptor-associated protein 1 OS=Homo sapiens OX=9606 GN=TGFBRAP1 PE=1 SV=1" "0.000" "False" "38.348" "12" "11" "11" "11" "860" "97.1" "6.55" "34.82" "11" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00637, Pf00780, Pf10366, Pf10367" "9392" "ENSG00000135966" "TGFBRAP1" "A8K5R7; D3DVJ8; hsa:9392; O60466; Q8WUH2" "" "" "0" "0" "1.045" "1.063" "1.116" "1.063" "1.098" "1.007" "1.010" "1.091" "1.117" "476.4" "497.8" "506.6" "531.5" "506.4" "523.2" "479.9" "481.2" "519.9" "532.0" "" "" "" "" "" "" "" "" "" "" "382.6" "359.2" "402.4" "356.1" "350.2" "392.6" "336.0" "351.4" "519.9" "432.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3087130677209166127" "False" "High" "IsMasterProtein" "O43566" "Regulator of G-protein signaling 14 OS=Homo sapiens OX=9606 GN=RGS14 PE=1 SV=4" "0.000" "False" "38.347" "18" "6" "9" "6" "566" "61.4" "8.19" "29.83" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00615, Pf02188, Pf02196" "10636" "ENSG00000169220" "RGS14" "hsa:10636; O43565; O43566; Q506M1; Q6ZWA4; Q8TD62" "G alpha (i) signalling events" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; 5q35 copy number variation" "4" "0" "0.948" "0.960" "1.041" "0.985" "0.901" "0.954" "0.962" "0.982" "0.976" "187.8" "178.0" "180.2" "195.5" "185.0" "169.3" "179.1" "180.7" "184.4" "183.3" "" "" "" "" "" "" "" "" "" "" "150.8" "128.4" "143.2" "131.0" "128.0" "127.0" "125.4" "131.9" "184.4" "149.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8559290960834017297" "False" "High" "IsMasterProtein" "O14976" "Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2" "0.000" "False" "38.292" "8" "8" "11" "8" "1311" "143.1" "5.73" "33.23" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf10409" "2580" "ENSG00000178950" "GAK" "hsa:2580; O14976; Q5U4P5; Q9BVY6" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "" "2" "0" "1.007" "0.975" "1.122" "1.012" "1.004" "0.956" "1.064" "1.079" "1.081" "564.8" "569.0" "550.5" "633.8" "571.5" "566.8" "539.8" "600.8" "609.5" "610.8" "" "" "" "" "" "" "" "" "" "" "453.6" "410.6" "437.3" "424.6" "395.3" "425.3" "378.0" "438.7" "609.5" "496.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8349989266333908893" "False" "High" "IsMasterProtein" "P49841" "Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2" "0.000" "False" "38.279" "23" "6" "11" "4" "420" "46.7" "8.78" "40.20" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2932" "ENSG00000082701" "GSK3B" "D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Regulation of HSF1-mediated heat shock response; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein" "IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)" "95" "0" "0.985" "0.977" "0.969" "0.969" "0.950" "0.908" "0.964" "0.945" "1.002" "241.1" "237.5" "235.6" "233.6" "233.7" "229.2" "218.8" "232.4" "227.8" "241.6" "" "" "" "" "" "" "" "" "" "" "193.7" "171.3" "187.2" "156.5" "161.6" "171.9" "153.2" "169.7" "227.8" "196.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7228226931451830335" "False" "High" "IsMasterProtein" "O15084" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5" "0.000" "False" "38.213" "8" "7" "10" "5" "1053" "112.9" "6.25" "30.27" "7" "" "cytosol;nucleus" "" "Pf00023, Pf12796" "23243" "ENSG00000206560" "ANKRD28" "B4DES5; hsa:23243; O15084; Q1WWL4; Q29RW6; Q3B857; Q6ULS0; Q6ZT57" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "1.012" "1.045" "1.145" "1.075" "1.055" "1.056" "1.152" "1.030" "1.028" "323.8" "327.8" "338.3" "370.9" "348.2" "341.6" "342.0" "373.0" "333.4" "332.8" "" "" "" "" "" "" "" "" "" "" "260.1" "236.5" "268.7" "248.5" "240.8" "256.3" "239.4" "272.4" "333.4" "270.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3098195104215073585" "False" "High" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "0.000" "False" "38.174" "36" "8" "15" "8" "212" "23.8" "8.27" "55.26" "8" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "3" "0" "0.944" "0.985" "0.966" "0.954" "1.059" "0.896" "0.913" "0.871" "0.987" "1273.4" "1202.5" "1253.9" "1229.5" "1214.6" "1348.3" "1141.3" "1162.9" "1109.6" "1256.3" "" "" "" "" "" "" "" "" "" "" "1022.8" "867.7" "996.0" "823.8" "840.0" "1011.6" "799.1" "849.3" "1109.6" "1021.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5839197527488627088" "False" "High" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "0.000" "False" "38.171" "26" "6" "6" "6" "424" "44.3" "8.44" "24.86" "6" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "11" "0" "1.017" "0.975" "1.118" "1.014" "1.024" "1.048" "1.014" "1.087" "1.055" "552.9" "562.5" "539.2" "618.2" "560.5" "566.3" "579.7" "560.5" "601.1" "583.5" "" "" "" "" "" "" "" "" "" "" "444.1" "405.9" "428.3" "414.2" "387.7" "424.9" "405.9" "409.3" "601.1" "474.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3673508278002205446" "False" "High" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "0.000" "False" "38.121" "29" "8" "9" "8" "298" "33.0" "9.22" "26.94" "8" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria" "4" "0" "1.019" "1.131" "0.939" "1.063" "1.085" "0.981" "1.056" "0.974" "1.032" "478.1" "487.4" "540.8" "448.9" "508.3" "518.9" "468.9" "504.8" "465.8" "493.2" "" "" "" "" "" "" "" "" "" "" "384.0" "351.7" "429.5" "300.7" "351.6" "389.3" "328.3" "368.7" "465.8" "401.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549591940651771702" "False" "High" "IsMasterProtein" "P17252" "Protein kinase C alpha type OS=Homo sapiens OX=9606 GN=PRKCA PE=1 SV=4" "0.000" "False" "38.117" "14" "8" "14" "5" "672" "76.7" "7.05" "29.50" "8" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00168, Pf00433" "5578" "ENSG00000154229" "PRKCA" "B5BU22; hsa:5578; P17252; Q15137; Q32M72; Q96RE4" "G alpha (z) signalling events; Disinhibition of SNARE formation; RET signaling; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; Ca2+ pathway; WNT5A-dependent internalization of FZD4; Inactivation, recovery and regulation of the phototransduction cascade; Syndecan interactions; HuR (ELAVL1) binds and stabilizes mRNA; VEGFR2 mediated cell proliferation; Trafficking of GluR2-containing AMPA receptors; Depolymerization of the Nuclear Lamina; Acetylcholine regulates insulin secretion; EGFR Transactivation by Gastrin; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; ROBO receptors bind AKAP5" "Target of rapamycin signaling; Thyroxine (thyroid hormone) production; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Endothelin pathways; Glioblastoma signaling pathways; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; T cell receptor and co-stimulatory signaling; Common pathways underlying drug addiction; Cardiac hypertrophic response; Complement system; Myometrial relaxation and contraction pathways; Transcriptional activation by NRF2 in response to phytochemicals; Kit receptor signaling pathway; Focal adhesion; Melatonin metabolism and effects; G protein signaling pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Ras signaling; Non-small cell lung cancer; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; NRF2-ARE regulation; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Fragile X syndrome; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Neuroinflammation and glutamatergic signaling; Orexin receptor pathway; Hippocampal synaptogenesis and neurogenesis; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; Osteoarthritic chondrocyte hypertrophy; ErbB signaling pathway" "75" "2" "0.943" "0.967" "1.048" "1.072" "1.000" "1.108" "1.096" "1.053" "1.005" "686.9" "647.6" "664.5" "719.6" "736.2" "687.2" "761.1" "753.1" "723.5" "690.4" "" "" "" "" "" "" "" "" "" "" "551.7" "467.3" "527.9" "482.1" "509.2" "515.6" "532.9" "550.0" "723.5" "561.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179011071974481602" "False" "High" "IsMasterProtein" "Q9NWS0" "PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1" "0.000" "False" "38.088" "29" "6" "9" "6" "290" "32.3" "5.14" "31.39" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08190, Pf18201" "55011" "ENSG00000104872" "PIH1D1" "B4DGN7; B4E2X7; hsa:55011; Q9BVL0; Q9NWS0" "" "" "0" "0" "1.164" "1.048" "1.027" "1.059" "1.049" "1.008" "1.054" "0.996" "1.073" "309.1" "359.7" "324.0" "317.5" "327.1" "324.1" "311.7" "325.9" "307.7" "331.7" "" "" "" "" "" "" "" "" "" "" "248.2" "259.5" "257.4" "212.7" "226.3" "243.2" "218.2" "238.0" "307.7" "269.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "609844474726423505" "False" "High" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "0.000" "False" "38.065" "53" "6" "12" "6" "158" "18.0" "8.66" "39.83" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; P50550; P63279; Q15698; Q59GX1; Q86VB3" "Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; PKR-mediated signaling; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Formation of Incision Complex in GG-NER; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "Androgen receptor signaling pathway; TGF-beta signaling pathway; TAR syndrome" "27" "0" "1.062" "1.073" "0.974" "1.034" "1.105" "1.013" "1.036" "1.028" "1.043" "1321.2" "1403.4" "1417.8" "1286.8" "1366.7" "1460.0" "1337.7" "1368.1" "1357.9" "1377.3" "" "" "" "" "" "" "" "" "" "" "1061.1" "1012.7" "1126.2" "862.2" "945.2" "1095.4" "936.6" "999.1" "1357.9" "1120.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7098201232450387464" "False" "High" "IsMasterProtein" "Q8N999" "RNA ligase 1 OS=Homo sapiens OX=9606 GN=RLIG1 PE=1 SV=2" "0.000" "False" "38.063" "20" "6" "8" "6" "325" "37.5" "7.06" "29.14" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "" "other molecular function" "Pf17720" "91298" "ENSG00000133641" "RLIG1" "Q569K5; Q6AWA8; Q6PEK5; Q8IYQ5; Q8N999; Q9NT75" "" "" "0" "0" "0.938" "0.976" "0.852" "0.967" "1.186" "0.901" "1.020" "0.971" "1.027" "503.1" "472.1" "491.0" "428.7" "486.6" "596.5" "453.5" "513.2" "488.4" "516.7" "" "" "" "" "" "" "" "" "" "" "404.1" "340.6" "390.1" "287.2" "336.5" "447.5" "317.5" "374.8" "488.4" "420.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1736163179168070894" "False" "High" "IsMasterProtein" "Q9Y2V7" "Conserved oligomeric Golgi complex subunit 6 OS=Homo sapiens OX=9606 GN=COG6 PE=1 SV=2" "0.000" "False" "38.049" "15" "10" "10" "10" "657" "73.2" "5.76" "31.73" "10" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf06419, Pf20653" "57511" "ENSG00000133103" "COG6" "hsa:57511; Q5T0U1; Q6AI19; Q86V49; Q9ULT5; Q9Y2V7" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "1.031" "1.011" "1.095" "1.002" "0.983" "0.979" "0.971" "1.016" "0.976" "682.6" "703.9" "690.4" "747.5" "684.1" "670.6" "668.0" "662.7" "693.4" "666.2" "" "" "" "" "" "" "" "" "" "" "548.2" "507.9" "548.4" "500.8" "473.1" "503.2" "467.7" "483.9" "693.4" "541.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766745797864106974" "False" "High" "IsMasterProtein" "O75528" "Transcriptional adapter 3 OS=Homo sapiens OX=9606 GN=TADA3 PE=1 SV=1" "0.000" "False" "38.020" "16" "5" "7" "5" "432" "48.9" "6.27" "27.04" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10198" "10474" "ENSG00000171148" "TADA3" "hsa:10474; O75528; Q6FI83; Q9UFS2" "Ub-specific processing proteases; Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "3" "0" "1.232" "1.080" "1.079" "1.082" "1.054" "0.918" "1.126" "1.134" "1.168" "275.1" "338.9" "297.2" "296.9" "297.6" "290.0" "252.6" "309.8" "312.0" "321.4" "" "" "" "" "" "" "" "" "" "" "221.0" "244.5" "236.1" "198.9" "205.8" "217.6" "176.9" "226.2" "312.0" "261.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7478524853152137733" "False" "High" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "0.000" "False" "37.969" "28" "7" "29" "7" "201" "23.3" "5.29" "85.02" "7" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "Rev-mediated nuclear export of HIV RNA" "22q11.2 copy number variation syndrome" "2" "0" "1.037" "1.078" "1.120" "1.132" "1.064" "1.125" "1.162" "1.150" "1.033" "1862.5" "1930.8" "2007.0" "2085.9" "2107.7" "1981.9" "2096.1" "2163.3" "2141.6" "1923.5" "" "" "" "" "" "" "" "" "" "" "1495.9" "1393.2" "1594.2" "1397.5" "1457.7" "1487.0" "1467.6" "1579.9" "2141.6" "1564.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2333660704476735765" "False" "High" "IsMasterProtein" "O15397" "Importin-8 OS=Homo sapiens OX=9606 GN=IPO8 PE=1 SV=2" "0.000" "False" "37.947" "8" "8" "11" "8" "1037" "119.9" "5.16" "38.87" "8" "transport;signal transduction" "cytosol;nucleus" "other molecular function" "Pf03810, Pf08506" "10526" "ENSG00000133704" "IPO8" "B7Z7M3; hsa:10526; O15397" "Transcriptional regulation by small RNAs" "Autophagy in pancreatic ductal adenocarcinoma" "2" "0" "1.012" "0.978" "0.928" "1.006" "1.002" "0.946" "1.028" "1.004" "1.008" "1007.6" "1020.0" "985.5" "934.9" "1013.5" "1009.9" "953.1" "1036.0" "1011.8" "1015.4" "" "" "" "" "" "" "" "" "" "" "809.3" "736.0" "782.8" "626.4" "700.9" "757.7" "667.3" "756.6" "1011.8" "825.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3153714913884480543" "False" "High" "IsMasterProtein" "Q8TAE8" "Large ribosomal subunit protein mL64 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "0.000" "False" "37.915" "36" "7" "10" "7" "222" "25.4" "10.02" "32.99" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.000" "0.899" "1.054" "1.074" "1.028" "1.008" "0.967" "1.011" "0.994" "609.2" "609.5" "547.8" "641.9" "654.5" "626.6" "614.1" "588.9" "615.9" "605.7" "" "" "" "" "" "" "" "" "" "" "489.3" "439.8" "435.1" "430.1" "452.7" "470.1" "430.0" "430.1" "615.9" "492.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2667466145755123608" "False" "High" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "0.000" "False" "37.840" "42" "4" "5" "4" "124" "13.7" "8.28" "24.35" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "1.069" "1.083" "1.044" "1.119" "1.080" "1.146" "1.056" "1.092" "1.086" "567.6" "606.7" "614.6" "592.7" "635.1" "613.2" "650.3" "599.5" "620.0" "616.7" "" "" "" "" "" "" "" "" "" "" "455.9" "437.8" "488.2" "397.1" "439.3" "460.1" "455.3" "437.8" "620.0" "501.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5067244968494119358" "False" "High" "IsMasterProtein" "O75496" "Geminin OS=Homo sapiens OX=9606 GN=GMNN PE=1 SV=1" "0.000" "False" "37.832" "34" "6" "14" "6" "209" "23.6" "4.96" "50.19" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07412" "51053" "ENSG00000112312" "GMNN" "B3KMM8; hsa:51053; O75496; Q9H1Z1" "Assembly of the pre-replicative complex; Activation of the pre-replicative complex; Switching of origins to a post-replicative state" "DNA replication; DYRK1A involvement regarding cell proliferation in brain development" "5" "0" "1.098" "1.048" "1.041" "1.081" "1.010" "1.375" "1.393" "1.374" "1.109" "841.5" "923.7" "881.9" "875.9" "909.3" "849.8" "1156.8" "1172.4" "1156.3" "933.4" "" "" "" "" "" "" "" "" "" "" "675.9" "666.5" "700.5" "586.8" "628.9" "637.6" "809.9" "856.2" "1156.3" "759.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8095037981369694658" "False" "High" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "0.000" "False" "37.819" "46" "6" "11" "6" "150" "17.1" "4.68" "36.38" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "1.015" "1.057" "0.962" "0.956" "1.040" "0.932" "0.964" "1.009" "0.959" "1292.5" "1312.2" "1365.8" "1243.3" "1235.9" "1343.8" "1205.0" "1245.6" "1304.5" "1239.5" "" "" "" "" "" "" "" "" "" "" "1038.1" "946.9" "1084.9" "833.0" "854.8" "1008.2" "843.7" "909.7" "1304.5" "1008.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190496341580409730" "False" "High" "IsMasterProtein" "Q5TAX3" "Terminal uridylyltransferase 4 OS=Homo sapiens OX=9606 GN=TUT4 PE=1 SV=3" "0.000" "False" "37.815" "7" "12" "12" "12" "1644" "185.0" "7.97" "39.00" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf01909, Pf03828, Pf19088" "23318" "ENSG00000134744" "TUT4" "A2RRP0; B7Z8J5; D3DQ35; hsa:23318; Q12764; Q5TAX2; Q5TAX3; Q5TAX4; Q86XZ3" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "" "3" "0" "1.005" "0.944" "1.063" "1.065" "1.026" "1.040" "1.009" "1.023" "1.065" "999.2" "1004.2" "943.6" "1062.0" "1064.4" "1024.9" "1039.1" "1008.4" "1021.9" "1064.3" "" "" "" "" "" "" "" "" "" "" "802.5" "724.6" "749.6" "711.5" "736.2" "769.0" "727.5" "736.5" "1021.9" "865.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1322674044200343444" "False" "High" "IsMasterProtein" "Q12789" "General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4" "0.000" "False" "37.799" "6" "11" "12" "11" "2109" "238.7" "7.30" "28.14" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04182" "2975" "ENSG00000077235" "GTF3C1" "B2RP21; hsa:2975; Q12789; Q12838; Q6DKN9; Q9Y4W9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "1.066" "0.982" "1.110" "1.069" "1.028" "1.010" "1.095" "1.035" "1.073" "525.5" "560.4" "516.1" "583.3" "561.6" "540.2" "531.0" "575.3" "544.1" "563.8" "" "" "" "" "" "" "" "" "" "" "422.1" "404.4" "410.0" "390.8" "388.4" "405.3" "371.7" "420.1" "544.1" "458.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486403724056782188" "False" "High" "IsMasterProtein" "Q7L8L6" "FAST kinase domain-containing protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD5 PE=1 SV=1" "0.000" "False" "37.779" "12" "7" "10" "7" "764" "86.5" "8.13" "32.39" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "60493" "ENSG00000215251" "FASTKD5" "hsa:60493; Q7L8L6; Q96JN3; Q9H5D1; Q9H8Y3" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "" "1" "0" "1.000" "1.023" "1.024" "1.040" "0.939" "0.968" "1.053" "0.972" "1.043" "452.3" "452.3" "462.7" "463.1" "470.2" "424.5" "437.8" "476.2" "439.5" "471.8" "" "" "" "" "" "" "" "" "" "" "363.3" "326.4" "367.5" "310.3" "325.2" "318.5" "306.5" "347.8" "439.5" "383.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5453029631849906368" "False" "High" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "0.000" "False" "37.768" "28" "9" "12" "9" "309" "35.8" "6.80" "37.57" "9" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "Vitamin B5 (pantothenate) metabolism" "" "1" "0" "1.004" "1.027" "1.011" "0.992" "1.010" "0.975" "1.009" "0.972" "0.948" "1207.0" "1212.0" "1239.8" "1220.5" "1197.7" "1218.9" "1176.6" "1218.4" "1173.4" "1144.6" "" "" "" "" "" "" "" "" "" "" "969.5" "874.5" "984.8" "817.7" "828.4" "914.5" "823.8" "889.8" "1173.4" "930.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5304133680658965036" "False" "High" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "0.000" "False" "37.758" "27" "7" "19" "6" "238" "27.4" "11.82" "48.99" "7" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "1" "0.997" "1.053" "1.116" "1.138" "1.149" "1.132" "1.065" "1.042" "1.076" "851.3" "848.8" "896.5" "950.2" "968.9" "978.2" "963.9" "906.5" "887.0" "916.1" "" "" "" "" "" "" "" "" "" "" "683.8" "612.5" "712.1" "636.7" "670.1" "733.9" "674.9" "662.0" "887.0" "745.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2208639490373230766" "False" "High" "IsMasterProtein" "Q92882" "Osteoclast-stimulating factor 1 OS=Homo sapiens OX=9606 GN=OSTF1 PE=1 SV=2" "0.000" "False" "37.713" "39" "5" "7" "5" "214" "23.8" "5.68" "29.68" "5" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00018, Pf12796" "26578" "ENSG00000134996" "OSTF1" "hsa:26578; Q5W126; Q92882; Q96IJ4" "Neutrophil degranulation" "" "1" "0" "1.050" "1.013" "0.998" "1.097" "1.100" "1.098" "1.110" "1.074" "1.113" "635.0" "667.0" "643.4" "633.7" "696.5" "698.4" "697.0" "704.9" "681.7" "706.9" "" "" "" "" "" "" "" "" "" "" "510.0" "481.3" "511.1" "424.6" "481.7" "524.0" "488.0" "514.8" "681.7" "574.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7158651141849584646" "False" "High" "IsMasterProtein" "Q9Y294" "Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1" "0.000" "False" "37.645" "39" "5" "9" "4" "204" "23.0" "4.41" "33.71" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04729" "25842" "ENSG00000111875" "ASF1A" "hsa:25842; Q6IA08; Q9P014; Q9Y294" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "22q11.2 copy number variation syndrome" "2" "0" "0.911" "0.912" "0.888" "0.923" "0.923" "0.829" "0.980" "0.946" "0.904" "258.1" "235.1" "235.4" "229.1" "238.1" "238.2" "214.0" "253.0" "244.2" "233.5" "" "" "" "" "" "" "" "" "" "" "207.3" "169.7" "187.0" "153.5" "164.7" "178.7" "149.8" "184.8" "244.2" "189.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080105971862608535" "False" "High" "IsMasterProtein" "Q9BYJ9" "YTH domain-containing family protein 1 OS=Homo sapiens OX=9606 GN=YTHDF1 PE=1 SV=1" "0.000" "False" "37.593" "12" "7" "11" "3" "559" "60.8" "8.79" "39.52" "7" "cell organization and biogenesis;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "54915" "ENSG00000149658" "YTHDF1" "hsa:54915; Q8N3G5; Q8TBT1; Q96AN4; Q96S57; Q9BTI7; Q9BYJ9; Q9NX79" "" "" "0" "0" "0.966" "0.991" "1.040" "1.098" "0.955" "0.931" "1.046" "0.967" "1.015" "321.2" "310.3" "318.4" "334.1" "352.8" "306.6" "299.1" "335.8" "310.7" "326.1" "" "" "" "" "" "" "" "" "" "" "258.0" "223.9" "252.9" "223.8" "244.0" "230.0" "209.4" "245.3" "310.7" "265.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463306019950863991" "False" "High" "IsMasterProtein" "O60784" "Target of Myb1 membrane trafficking protein OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2" "0.000" "False" "37.519" "14" "6" "8" "6" "492" "53.8" "4.70" "24.70" "6" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00790, Pf03127" "10043" "ENSG00000100284" "TOM1" "B4DEL9; B4DNA1; hsa:10043; O60784; Q5TIJ6; Q86X74" "Neutrophil degranulation" "" "1" "0" "1.127" "1.032" "1.072" "1.040" "1.007" "0.987" "0.974" "1.067" "1.037" "332.7" "375.0" "343.5" "356.6" "345.9" "334.9" "328.4" "324.1" "354.9" "345.1" "" "" "" "" "" "" "" "" "" "" "267.2" "270.6" "272.8" "238.9" "239.2" "251.2" "230.0" "236.7" "354.9" "280.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7964397888877464485" "False" "High" "IsMasterProtein" "P50897" "Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1" "0.000" "False" "37.517" "20" "5" "8" "5" "306" "34.2" "6.52" "29.95" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02089" "5538" "ENSG00000131238" "PPT1" "B4DY24; hsa:5538; P50897; Q6FGQ4" "Fatty acyl-CoA biosynthesis" "" "1" "0" "0.954" "0.933" "0.948" "0.990" "1.042" "0.935" "0.973" "1.023" "0.962" "856.8" "817.7" "799.6" "812.5" "848.1" "892.5" "801.2" "833.7" "876.8" "824.1" "" "" "" "" "" "" "" "" "" "" "688.2" "590.0" "635.2" "544.4" "586.5" "669.6" "561.0" "608.8" "876.8" "670.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5687850324260335343" "False" "High" "IsMasterProtein" "Q16875" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens OX=9606 GN=PFKFB3 PE=1 SV=1" "0.000" "False" "37.470" "20" "8" "9" "8" "520" "59.6" "8.21" "31.24" "8" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5209" "ENSG00000170525" "PFKFB3" "B7Z955; hsa:5209; O43622; O75902; Q16875; Q5VX15; Q5VX18; Q5VX19" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "3" "0" "1.048" "1.049" "1.054" "1.013" "1.044" "1.000" "0.947" "1.019" "1.028" "524.9" "550.0" "550.5" "553.5" "531.6" "547.9" "524.7" "497.1" "535.1" "539.9" "" "" "" "" "" "" "" "" "" "" "421.6" "396.9" "437.3" "370.8" "367.6" "411.1" "367.4" "363.0" "535.1" "439.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158883592383283846" "False" "High" "IsMasterProtein" "P60983" "Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2" "0.000" "False" "37.469" "37" "5" "9" "4" "142" "16.7" "5.29" "35.24" "5" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "2764" "ENSG00000197045" "GMFB" "B2R499; hsa:2764; P17774; P60983; Q9BS35" "" "" "0" "1" "1.005" "1.014" "0.977" "0.937" "0.943" "0.962" "0.887" "0.977" "0.961" "1294.1" "1300.9" "1312.2" "1264.4" "1212.6" "1219.7" "1245.3" "1147.9" "1263.7" "1244.2" "" "" "" "" "" "" "" "" "" "" "1039.4" "938.7" "1042.3" "847.1" "838.7" "915.1" "871.9" "838.3" "1263.7" "1011.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236984144033134213" "False" "High" "IsMasterProtein" "Q9NV70" "Exocyst complex component 1 OS=Homo sapiens OX=9606 GN=EXOC1 PE=1 SV=4" "0.000" "False" "37.467" "10" "10" "12" "10" "894" "101.9" "6.61" "37.26" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf09763, Pf15277, Pf20654" "55763" "ENSG00000090989" "EXOC1" "hsa:55763; Q504V4; Q8WUE7; Q96T15; Q9NV70; Q9NZE4" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "1.026" "1.024" "1.042" "0.965" "0.937" "0.968" "0.935" "1.003" "1.000" "1340.9" "1375.9" "1372.5" "1397.0" "1293.4" "1257.0" "1298.3" "1253.9" "1345.4" "1340.4" "" "" "" "" "" "" "" "" "" "" "1077.0" "992.8" "1090.2" "936.0" "894.5" "943.1" "909.0" "915.7" "1345.4" "1090.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3077097618423052072" "False" "High" "IsMasterProtein" "Q15032" "R3H domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HDM1 PE=1 SV=3" "0.000" "False" "37.451" "6" "6" "6" "6" "1099" "120.6" "8.75" "23.22" "6" "" "" "" "Pf01424, Pf12752" "23518" "ENSG00000048991" "R3HDM1" "A8K1V0; B3KXQ9; E9PBB4; E9PG42; G5E9G8; hsa:23518; Q15032; Q8IW32" "" "" "0" "0" "0.920" "0.923" "0.884" "0.949" "0.973" "0.905" "0.932" "0.970" "0.950" "294.4" "270.8" "271.9" "260.3" "279.4" "286.4" "266.5" "274.5" "285.6" "279.6" "" "" "" "" "" "" "" "" "" "" "236.5" "195.4" "216.0" "174.4" "193.3" "214.9" "186.6" "200.5" "285.6" "227.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "175169128914004892" "False" "High" "IsMasterProtein" "Q30154" "HLA class II histocompatibility antigen, DR beta 5 chain OS=Homo sapiens OX=9606 GN=HLA-DRB5 PE=1 SV=1" "0.000" "False" "37.444" "27" "7" "9" "4" "266" "30.0" "6.93" "35.73" "7" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3127" "ENSG00000198502" "HLA-DRB5" "B2RBV6; C7C4X3; hsa:3127; O00157; O00283; O46700; Q29703; Q29787; Q29788; Q30126; Q30150; Q30154; Q30199; Q6SJR2; Q7M2H9; Q8HWS7; Q8WLR5; Q9MY54; Q9XRX6" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "11" "3" "0.929" "0.895" "0.882" "0.981" "1.079" "1.122" "0.889" "1.077" "0.939" "1393.3" "1294.7" "1247.1" "1229.5" "1367.2" "1503.2" "1563.7" "1239.2" "1501.1" "1307.7" "" "" "" "" "" "" "" "" "" "" "1119.1" "934.2" "990.6" "823.8" "945.5" "1127.8" "1094.8" "905.0" "1501.1" "1063.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7526904377414410620" "False" "High" "IsMasterProtein" "Q6NXR4" "TELO2-interacting protein 2 OS=Homo sapiens OX=9606 GN=TTI2 PE=1 SV=1" "0.000" "False" "37.418" "15" "7" "9" "7" "508" "56.9" "7.09" "30.76" "7" "other biological processes" "nucleus;other cell component" "" "Pf10521" "80185" "ENSG00000129696" "TTI2" "D3DSV7; hsa:80185; Q6NXR4; Q96IM2; Q9H5N4" "" "" "0" "0" "1.054" "1.094" "1.137" "1.024" "1.015" "0.955" "1.107" "1.095" "1.061" "321.0" "338.2" "351.1" "365.1" "328.5" "325.8" "306.5" "355.3" "351.4" "340.6" "" "" "" "" "" "" "" "" "" "" "257.8" "244.0" "278.9" "244.6" "227.2" "244.4" "214.6" "259.5" "351.4" "277.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-474422990152712875" "False" "High" "IsMasterProtein" "P61923" "Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1" "0.000" "False" "37.411" "23" "3" "8" "3" "177" "20.2" "4.81" "30.11" "3" "transport" "other membranes;cytosol;ER/Golgi" "" "Pf01217" "22818" "ENSG00000111481" "COPZ1" "B4DDX8; B4DHZ0; F8VS17; F8VWL5; hsa:22818; P61923; Q549N6; Q9Y3C3" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.037" "0.973" "1.025" "0.972" "0.961" "0.880" "0.919" "0.936" "1.003" "468.4" "485.9" "455.7" "479.9" "455.2" "450.2" "412.2" "430.5" "438.4" "469.9" "" "" "" "" "" "" "" "" "" "" "376.3" "350.6" "361.9" "321.6" "314.8" "337.7" "288.6" "314.4" "438.4" "382.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9154000995379348407" "False" "High" "IsMasterProtein" "Q16644" "MAP kinase-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPKAPK3 PE=1 SV=1" "0.000" "False" "37.396" "22" "8" "15" "5" "382" "43.0" "7.28" "44.57" "8" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7867" "ENSG00000114738" "MAPKAPK3" "B5BU67; hsa:7867; Q16644" "VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; p38MAPK events; activated TAK1 mediates p38 MAPK activation" "Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Serotonin HTR1 group and FOS pathway" "7" "3" "0.995" "1.019" "0.940" "0.925" "0.986" "0.950" "0.950" "0.927" "0.934" "1444.0" "1436.6" "1470.9" "1357.5" "1335.4" "1423.6" "1371.6" "1371.9" "1338.5" "1348.0" "" "" "" "" "" "" "" "" "" "" "1159.8" "1036.6" "1168.4" "909.5" "923.6" "1068.1" "960.3" "1001.9" "1338.5" "1096.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2076533743620825156" "False" "High" "IsMasterProtein" "Q02080" "Myocyte-specific enhancer factor 2B OS=Homo sapiens OX=9606 GN=MEF2B PE=1 SV=2" "0.000" "False" "37.340" "18" "5" "8" "5" "365" "38.6" "9.48" "31.07" "5" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319" "100271849; 4207" "ENSG00000213999" "MEF2B" "A0AV80; B4DVH7; B7ZVY1; G5E9M1; hsa:100271849; hsa:4207; Q02080" "Myogenesis" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Gastrin signaling pathway" "7" "0" "1.067" "1.015" "1.034" "0.997" "0.999" "0.876" "0.999" "1.013" "1.024" "962.2" "1026.7" "976.9" "995.4" "959.3" "961.4" "842.7" "960.8" "974.3" "985.6" "" "" "" "" "" "" "" "" "" "" "772.8" "740.9" "776.0" "666.9" "663.5" "721.3" "590.0" "701.7" "974.3" "801.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4293780430971367314" "False" "High" "IsMasterProtein" "Q13371" "Phosducin-like protein OS=Homo sapiens OX=9606 GN=PDCL PE=1 SV=3" "0.000" "False" "37.331" "20" "5" "8" "5" "301" "34.3" "4.73" "33.83" "5" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf02114" "5082" "ENSG00000136940" "PDCL" "hsa:5082; Q13371; Q4VXB6; Q96AF1; Q9UEW7; Q9UFL0; Q9UNX1; Q9UNX2" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" "" "1" "0" "0.976" "0.903" "0.983" "0.902" "0.923" "0.935" "0.970" "0.890" "0.931" "592.1" "578.0" "534.9" "582.2" "534.2" "546.5" "553.6" "574.4" "527.1" "551.0" "" "" "" "" "" "" "" "" "" "" "475.6" "417.1" "424.9" "390.0" "369.4" "410.1" "387.6" "419.5" "527.1" "448.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2836691942658563138" "False" "High" "IsMasterProtein" "Q8TEP8" "Centrosomal protein of 192 kDa OS=Homo sapiens OX=9606 GN=CEP192 PE=1 SV=3" "0.000" "False" "37.328" "4" "8" "8" "8" "2537" "278.9" "5.48" "26.58" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55125" "ENSG00000101639" "CEP192" "A0A060A9S4; B7ZMF0; E9PF99; hsa:55125; Q8TEP8; Q8WYT8; Q9H0F4; Q9NW27" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Gastric cancer network 1; Genes related to primary cilium development (based on CRISPR); Alstrom syndrome" "10" "0" "0.953" "0.991" "1.075" "0.942" "0.933" "1.112" "0.968" "0.870" "0.961" "149.9" "142.8" "148.5" "161.1" "141.1" "139.8" "166.6" "145.0" "130.4" "144.0" "" "" "" "" "" "" "" "" "" "" "120.4" "103.0" "118.0" "108.0" "97.6" "104.9" "116.6" "105.9" "130.4" "117.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386790215885090291" "False" "High" "IsMasterProtein" "Q8N3X1" "Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3" "0.000" "False" "37.324" "9" "7" "9" "7" "1017" "110.2" "4.74" "24.44" "7" "" "nucleus" "" "Pf00397" "23360" "ENSG00000109920; ENSG00000285182" "FNBP4" "hsa:23360; Q8N3X1; Q9H985; Q9NT81; Q9Y2L7" "" "" "0" "0" "0.968" "0.909" "1.042" "1.159" "1.037" "1.104" "1.015" "0.946" "0.969" "448.5" "434.3" "407.8" "467.2" "519.9" "465.2" "495.2" "455.1" "424.5" "434.4" "" "" "" "" "" "" "" "" "" "" "360.2" "313.4" "323.9" "313.1" "359.6" "349.1" "346.7" "332.4" "424.5" "353.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7687733002656654502" "False" "High" "IsMasterProtein" "P18031" "Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1" "0.000" "False" "37.294" "21" "8" "9" "8" "435" "49.9" "6.27" "33.25" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5770" "ENSG00000196396" "PTPN1" "hsa:5770; P18031; Q5TGD8; Q9BQV9; Q9NQQ4" "Insulin receptor recycling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Negative regulation of MET activity; Integrin signaling; MECP2 regulates neuronal receptors and channels; PTK6 Down-Regulation" "Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "14" "0" "1.082" "1.002" "1.066" "1.033" "0.993" "1.045" "0.982" "1.116" "0.979" "447.1" "483.6" "447.8" "476.5" "461.9" "444.2" "467.2" "439.2" "499.1" "437.8" "" "" "" "" "" "" "" "" "" "" "359.1" "349.0" "355.7" "319.2" "319.5" "333.3" "327.1" "320.8" "499.1" "356.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8687914292583263366" "False" "High" "IsMasterProtein" "O60307" "Microtubule-associated serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=MAST3 PE=1 SV=2" "0.000" "False" "37.282" "6" "6" "8" "5" "1309" "143.0" "8.06" "30.83" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf08926, Pf17820" "23031" "ENSG00000099308" "MAST3" "hsa:23031; O60307; Q7LDZ8; Q9UPI0" "" "" "0" "0" "1.149" "1.027" "1.100" "1.201" "1.117" "1.153" "1.216" "1.312" "1.145" "305.2" "350.7" "313.3" "335.7" "366.7" "341.0" "351.8" "371.3" "400.4" "349.3" "" "" "" "" "" "" "" "" "" "" "245.1" "253.0" "248.9" "224.9" "253.6" "255.8" "246.3" "271.1" "400.4" "284.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272121550069660062" "False" "High" "IsMasterProtein" "P35268" "Large ribosomal subunit protein eL22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "0.000" "False" "37.215" "51" "4" "7" "4" "128" "14.8" "9.19" "27.69" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.856" "0.989" "1.161" "1.109" "1.108" "1.356" "1.100" "1.121" "1.089" "444.8" "380.8" "440.0" "516.4" "493.1" "492.9" "603.2" "489.3" "498.5" "484.6" "" "" "" "" "" "" "" "" "" "" "357.3" "274.8" "349.5" "346.0" "341.1" "369.8" "422.3" "357.4" "498.5" "394.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072204051848657082" "False" "High" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "0.000" "False" "37.208" "32" "5" "9" "5" "226" "24.4" "6.10" "28.78" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "61" "0" "1.110" "1.039" "1.182" "1.164" "1.025" "1.070" "1.025" "1.072" "1.044" "380.2" "421.9" "394.8" "449.4" "442.4" "389.8" "406.8" "389.7" "407.5" "396.8" "" "" "" "" "" "" "" "" "" "" "305.4" "304.4" "313.6" "301.1" "306.0" "292.5" "284.8" "284.6" "407.5" "322.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2490332894624900384" "False" "High" "IsMasterProtein" "Q92574" "Hamartin OS=Homo sapiens OX=9606 GN=TSC1 PE=1 SV=2" "0.000" "False" "37.167" "8" "9" "11" "9" "1164" "129.7" "6.47" "31.26" "9" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04388" "7248" "ENSG00000165699" "TSC1" "B7Z897; hsa:7248; Q5VVN5; Q92574" "Macroautophagy; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "27" "0" "1.094" "1.073" "1.091" "1.148" "1.124" "1.044" "1.117" "1.144" "1.182" "262.1" "286.8" "281.4" "286.1" "300.9" "294.5" "273.6" "292.9" "299.7" "309.9" "" "" "" "" "" "" "" "" "" "" "210.5" "207.0" "223.5" "191.7" "208.1" "221.0" "191.6" "213.9" "299.7" "252.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4427751732173954290" "False" "High" "IsMasterProtein" "Q99700" "Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2" "0.000" "False" "37.132" "8" "9" "12" "8" "1313" "140.2" "9.57" "37.95" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "6311" "ENSG00000204842" "ATXN2" "A6NLD4; hsa:6311; Q24JQ7; Q6ZQZ7; Q99493; Q99700" "" "Parkinson's disease pathway; EGF/EGFR signaling pathway" "2" "0" "0.996" "1.000" "1.042" "1.048" "1.055" "1.098" "1.111" "1.066" "1.055" "321.8" "320.5" "321.6" "335.1" "337.1" "339.5" "353.4" "357.3" "343.1" "339.5" "" "" "" "" "" "" "" "" "" "" "258.4" "231.3" "255.5" "224.5" "233.2" "254.7" "247.4" "261.0" "343.1" "276.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7736250579698754769" "False" "High" "IsMasterProtein" "Q8IV53" "DENN domain-containing protein 1C OS=Homo sapiens OX=9606 GN=DENND1C PE=1 SV=1" "0.000" "False" "37.126" "9" "6" "8" "6" "801" "87.0" "5.67" "30.66" "6" "transport" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02141, Pf03455, Pf03456" "79958" "ENSG00000205744" "DENND1C" "B4E051; D3PFD4; hsa:79958; Q8IV53; Q8NDB1; Q9H5Z2" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.067" "1.014" "1.128" "1.027" "1.081" "1.016" "1.033" "1.071" "1.110" "267.5" "285.3" "271.3" "301.6" "274.6" "289.0" "271.7" "276.3" "286.5" "296.8" "" "" "" "" "" "" "" "" "" "" "214.8" "205.9" "215.5" "202.1" "189.9" "216.9" "190.2" "201.8" "286.5" "241.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5898955459380036323" "False" "High" "IsMasterProtein" "Q05048" "Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1" "0.000" "False" "37.088" "22" "9" "12" "9" "431" "48.3" "6.58" "33.27" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00400, Pf16699" "1477" "ENSG00000101138" "CSTF1" "hsa:1477; Q05048; Q5QPD8" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "0.959" "0.997" "1.114" "1.135" "1.070" "1.093" "1.074" "1.030" "1.104" "681.8" "653.8" "679.8" "759.8" "773.8" "729.5" "745.4" "732.4" "702.1" "752.9" "" "" "" "" "" "" "" "" "" "" "547.6" "471.8" "540.0" "509.1" "535.2" "547.3" "521.9" "534.9" "702.1" "612.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3284671458686948130" "False" "High" "IsMasterProtein" "Q14498" "RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2" "0.000" "False" "37.069" "9" "4" "7" "4" "530" "59.3" "10.10" "29.69" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00076, Pf15519" "9584" "ENSG00000131051" "RBM39" "A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1; hsa:9584; Q14498; Q14499" "mRNA Splicing - Major Pathway" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "1.023" "1.089" "1.005" "0.940" "1.070" "0.988" "1.070" "1.039" "1.073" "780.1" "798.2" "849.4" "784.3" "733.1" "835.1" "770.5" "834.6" "810.8" "837.3" "" "" "" "" "" "" "" "" "" "" "626.6" "575.9" "674.7" "525.5" "507.0" "626.5" "539.5" "609.5" "810.8" "680.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1396372760161625634" "False" "High" "IsMasterProtein" "Q8N129" "Protein canopy homolog 4 OS=Homo sapiens OX=9606 GN=CNPY4 PE=1 SV=1" "0.000" "False" "37.017" "26" "5" "7" "5" "248" "28.3" "4.64" "27.82" "5" "other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf11938" "245812" "ENSG00000166997" "CNPY4" "hsa:245812; Q8N129; Q8WUN9" "" "" "0" "0" "1.049" "0.932" "1.009" "0.945" "1.013" "1.068" "1.064" "1.031" "1.008" "308.3" "323.4" "287.2" "311.2" "291.4" "312.3" "329.2" "328.0" "318.0" "310.6" "" "" "" "" "" "" "" "" "" "" "247.6" "233.4" "228.1" "208.5" "201.5" "234.3" "230.5" "239.5" "318.0" "252.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2420827179212213562" "False" "High" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "0.000" "False" "36.976" "7" "8" "8" "8" "1438" "162.1" "5.36" "25.56" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation; PAFAH1B1 copy number variation" "9" "0" "0.986" "0.966" "1.101" "1.111" "1.059" "1.088" "1.040" "1.076" "1.034" "370.1" "365.0" "357.7" "407.7" "411.3" "392.1" "402.8" "384.8" "398.4" "382.8" "" "" "" "" "" "" "" "" "" "" "297.3" "263.3" "284.1" "273.1" "284.5" "294.2" "282.0" "281.0" "398.4" "311.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631666065222226929" "False" "High" "IsMasterProtein" "P42898" "Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3" "0.000" "False" "36.973" "18" "11" "12" "11" "656" "74.5" "5.34" "36.65" "11" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf02219" "4524" "ENSG00000177000" "MTHFR" "B2R7A6; hsa:4524; P42898; Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2" "Metabolism of folate and pterines" "Glycine metabolism; Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; MTHFR deficiency; Male infertility; Spina bifida" "14" "0" "0.920" "0.965" "0.946" "0.961" "0.933" "0.917" "0.951" "0.933" "0.953" "874.2" "804.1" "843.8" "826.9" "840.5" "815.6" "801.7" "831.5" "815.4" "833.4" "" "" "" "" "" "" "" "" "" "" "702.2" "580.2" "670.2" "554.0" "581.3" "612.0" "561.3" "607.3" "815.4" "677.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4102844417532121967" "False" "High" "IsMasterProtein" "Q15560" "Transcription elongation factor A protein 2 OS=Homo sapiens OX=9606 GN=TCEA2 PE=1 SV=1" "0.000" "False" "36.965" "21" "6" "8" "4" "299" "33.6" "9.13" "27.75" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6919" "ENSG00000171703" "TCEA2" "B3KNM1; Q15560; Q8TD37; Q8TD38" "" "" "0" "0" "1.120" "1.069" "1.201" "1.138" "1.104" "1.169" "1.088" "1.151" "1.185" "352.5" "395.0" "376.9" "423.5" "401.1" "389.0" "412.1" "383.5" "405.7" "417.8" "" "" "" "" "" "" "" "" "" "" "283.1" "285.0" "299.4" "283.7" "277.4" "291.9" "288.5" "280.0" "405.7" "339.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8588512168019091393" "False" "High" "IsMasterProtein" "Q5FWF5" "N-acetyltransferase ESCO1 OS=Homo sapiens OX=9606 GN=ESCO1 PE=1 SV=3" "0.000" "False" "36.941" "10" "9" "10" "9" "840" "94.9" "9.16" "31.53" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13878, Pf13880" "114799" "ENSG00000141446" "ESCO1" "B0YJ11; B0YJ12; hsa:114799; Q5FWF5; Q69YG4; Q69YS3; Q6IMD7; Q8N3Z5; Q8NBG2; Q96PX7" "Establishment of Sister Chromatid Cohesion" "Cohesin complex - Cornelia de Lange syndrome" "2" "0" "1.106" "1.073" "1.015" "0.989" "1.039" "0.967" "0.925" "1.088" "1.005" "1011.8" "1119.0" "1085.4" "1026.9" "1000.4" "1051.6" "978.5" "936.0" "1100.8" "1016.8" "" "" "" "" "" "" "" "" "" "" "812.7" "807.4" "862.2" "688.0" "691.9" "789.0" "685.1" "683.6" "1100.8" "826.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8307908846177998742" "False" "High" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "0.000" "False" "36.935" "23" "7" "11" "7" "432" "48.5" "6.54" "29.80" "7" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; Photodynamic therapy-induced AP-1 survival signaling; IL-18 signaling pathway; Acute myeloid leukemia; NF1 copy number variation syndrome" "27" "0" "1.086" "0.988" "1.045" "1.024" "0.944" "1.274" "1.224" "1.138" "1.066" "542.4" "589.0" "535.8" "566.7" "555.5" "511.9" "690.8" "663.9" "617.3" "578.1" "" "" "" "" "" "" "" "" "" "" "435.6" "425.0" "425.6" "379.7" "384.2" "384.1" "483.6" "484.8" "617.3" "470.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965973480370309944" "False" "High" "IsMasterProtein" "Q53HC9" "EARP and GARP complex-interacting protein 1 OS=Homo sapiens OX=9606 GN=EIPR1 PE=1 SV=2" "0.000" "False" "36.868" "20" "6" "6" "6" "387" "43.6" "5.06" "25.98" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "" "Pf00400" "7260" "ENSG00000032389" "EIPR1" "D6W4Y1; hsa:7260; O43179; Q53HC9; Q53S19; Q53SG2" "" "Ciliary landscape" "1" "0" "0.985" "0.972" "0.985" "0.986" "1.005" "1.008" "0.938" "0.975" "1.010" "579.6" "570.6" "563.5" "571.0" "571.2" "582.6" "584.0" "543.4" "564.9" "585.1" "" "" "" "" "" "" "" "" "" "" "465.5" "411.7" "447.6" "382.6" "395.1" "437.1" "408.9" "396.8" "564.9" "475.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385363124040609264" "False" "High" "IsMasterProtein" "Q13217" "DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1" "0.000" "False" "36.846" "17" "8" "9" "7" "504" "57.5" "6.15" "28.15" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00226, Pf00515, Pf13181" "5611" "ENSG00000102580" "DNAJC3" "hsa:5611; Q13217; Q86WT9; Q8N4N2" "Neutrophil degranulation; Viral mRNA Translation; PKR-mediated signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response" "7" "0" "1.045" "0.911" "1.043" "0.993" "0.978" "1.053" "1.079" "1.077" "1.011" "1068.7" "1116.7" "973.5" "1114.9" "1060.8" "1045.5" "1125.0" "1152.6" "1151.1" "1080.6" "" "" "" "" "" "" "" "" "" "" "858.4" "805.8" "773.3" "747.0" "733.7" "784.4" "787.7" "841.8" "1151.1" "878.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5950667386624240413" "False" "High" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "0.000" "False" "36.828" "5" "11" "11" "8" "2364" "274.4" "5.57" "31.80" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; COPI-mediated anterograde transport; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Signaling by FLT3 fusion proteins" "TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "0.947" "0.928" "1.059" "1.038" "1.007" "1.182" "1.010" "1.035" "0.995" "937.0" "887.3" "869.8" "992.1" "972.5" "943.2" "1107.8" "946.2" "969.6" "931.9" "" "" "" "" "" "" "" "" "" "" "752.6" "640.3" "690.9" "664.7" "672.6" "707.6" "775.6" "691.0" "969.6" "757.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8932263568853688601" "False" "High" "IsMasterProtein" "Q9UKA9" "Polypyrimidine tract-binding protein 2 OS=Homo sapiens OX=9606 GN=PTBP2 PE=1 SV=1" "0.000" "False" "36.787" "17" "8" "10" "7" "531" "57.5" "8.66" "32.57" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "58155" "ENSG00000117569" "PTBP2" "hsa:58155; Q8N0Z1; Q8N160; Q8NFB0; Q8NFB1; Q969N9; Q96Q76; Q9UKA9" "" "Genes targeted by miRNAs in adipocytes; mRNA processing" "2" "0" "1.086" "1.065" "1.096" "1.161" "1.026" "1.152" "1.170" "1.070" "1.090" "380.2" "413.0" "404.7" "416.5" "441.3" "390.2" "437.9" "444.9" "406.9" "414.2" "" "" "" "" "" "" "" "" "" "" "305.3" "298.0" "321.5" "279.1" "305.2" "292.8" "306.6" "324.9" "406.9" "336.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8489357358395881882" "False" "High" "IsMasterProtein" "Q86SX6" "Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2" "0.000" "False" "36.756" "32" "4" "7" "4" "157" "16.6" "6.79" "29.59" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00462" "51218" "ENSG00000182512" "GLRX5" "hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54" "Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "2" "0" "1.231" "1.131" "1.168" "1.074" "1.166" "1.163" "1.158" "1.146" "1.165" "342.3" "421.2" "386.9" "399.7" "367.6" "399.1" "397.9" "396.3" "392.4" "398.6" "" "" "" "" "" "" "" "" "" "" "274.9" "303.9" "307.4" "267.8" "254.2" "299.5" "278.6" "289.5" "392.4" "324.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4707319533501773453" "False" "High" "IsMasterProtein" "O95260" "Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2" "0.000" "False" "36.691" "18" "7" "7" "7" "518" "59.1" "7.93" "25.25" "7" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04376, Pf04377" "11101" "ENSG00000107669" "ATE1" "hsa:11101; O95260; O95261; Q5SQQ3; Q8WW04" "" "" "0" "0" "1.056" "1.040" "1.105" "1.082" "1.106" "1.053" "1.061" "1.046" "1.068" "574.3" "606.5" "597.2" "634.7" "621.6" "635.2" "604.7" "609.1" "600.6" "613.5" "" "" "" "" "" "" "" "" "" "" "461.2" "437.6" "474.4" "425.2" "429.9" "476.5" "423.4" "444.8" "600.6" "498.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "272489793728892869" "False" "High" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "0.000" "False" "36.688" "32" "7" "8" "7" "234" "26.1" "7.78" "28.06" "7" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "0.931" "0.918" "1.026" "0.948" "1.007" "1.019" "1.083" "1.040" "0.967" "695.1" "647.0" "638.0" "713.1" "658.8" "700.1" "708.0" "752.8" "722.7" "672.4" "" "" "" "" "" "" "" "" "" "" "558.3" "466.9" "506.8" "477.8" "455.6" "525.2" "495.7" "549.8" "722.7" "546.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4676575217961373957" "False" "High" "IsMasterProtein" "P63098" "Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2" "0.000" "False" "36.665" "37" "4" "9" "4" "170" "19.3" "4.81" "30.82" "4" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "5534" "ENSG00000221823" "PPP3R1" "B2RC10; B5MDU4; hsa:5534; P06705; P15117; P63098; Q08044; Q53SL0" "Ca2+ pathway; FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; Activation of BAD and translocation to mitochondria" "Energy metabolism; Transcription factors regulate miRNAs related to cardiac hypertrophy; Alzheimer's disease and miRNA effects; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Vitamin D in inflammatory diseases; Regucalcin in proximal tubule epithelial kidney cells; Alzheimer's disease" "15" "0" "1.020" "1.080" "0.991" "0.890" "0.962" "0.986" "0.996" "0.969" "0.977" "1024.5" "1045.3" "1106.4" "1015.3" "911.4" "985.3" "1010.6" "1020.3" "993.2" "1000.6" "" "" "" "" "" "" "" "" "" "" "822.9" "754.3" "878.8" "680.3" "630.3" "739.2" "707.6" "745.1" "993.2" "813.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5517999105151406307" "False" "High" "IsMasterProtein" "Q9NWT1" "p21-activated protein kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAK1IP1 PE=1 SV=2" "0.000" "False" "36.664" "16" "5" "6" "5" "392" "43.9" "8.91" "25.33" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf00400" "55003" "ENSG00000111845; ENSG00000285226" "PAK1IP1" "hsa:55003; Q5T4J2; Q96QJ8; Q96T87; Q9NWT1" "" "" "0" "0" "1.155" "1.476" "1.242" "1.265" "1.217" "1.149" "1.179" "1.063" "1.465" "52.3" "60.4" "77.1" "64.9" "66.1" "63.6" "60.0" "61.6" "55.6" "76.5" "" "" "" "" "" "" "" "" "" "" "42.0" "43.6" "61.3" "43.5" "45.7" "47.7" "42.0" "45.0" "55.6" "62.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5424828533558395863" "False" "High" "IsMasterProtein" "O95352" "Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1" "0.000" "False" "36.663" "13" "8" "9" "8" "703" "77.9" "6.24" "30.23" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00899, Pf16420" "10533" "ENSG00000197548" "ATG7" "B4E170; E9PB95; hsa:10533; O95352; Q7L8L0; Q9BWP2; Q9UFH4" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Macroautophagy" "Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; Primary ovarian insufficiency; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "12" "0" "0.999" "1.020" "1.042" "1.137" "1.067" "1.081" "1.133" "1.072" "1.092" "830.8" "830.3" "847.0" "865.7" "944.9" "886.5" "898.0" "941.1" "890.3" "907.3" "" "" "" "" "" "" "" "" "" "" "667.3" "599.1" "672.8" "580.0" "653.5" "665.1" "628.7" "687.3" "890.3" "737.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6333223318553199487" "False" "High" "IsMasterProtein" "Q14919" "Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3" "0.000" "False" "36.618" "35" "6" "9" "6" "205" "22.3" "5.17" "28.04" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00808" "10589" "ENSG00000175550" "DRAP1" "hsa:10589; Q13448; Q14919" "Signaling by NODAL; Signaling by Activin" "" "2" "0" "1.012" "0.929" "1.041" "1.024" "1.073" "1.028" "0.994" "0.940" "1.002" "555.1" "561.9" "515.7" "578.0" "568.3" "595.9" "570.7" "551.8" "521.6" "556.5" "" "" "" "" "" "" "" "" "" "" "445.9" "405.5" "409.6" "387.2" "393.0" "447.1" "399.6" "403.0" "521.6" "452.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9069432479560653681" "False" "High" "IsMasterProtein" "Q08AM6" "Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1" "0.000" "False" "36.569" "13" "8" "8" "8" "782" "87.9" "6.13" "25.57" "8" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11916, Pf12755" "55697" "ENSG00000103043" "VAC14" "B3KPJ5; B3KSM8; hsa:55697; Q08AM6; Q13174; Q6IA12; Q7L4Y1; Q9BW96; Q9H6V6" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "1.032" "1.050" "1.019" "1.087" "1.085" "1.081" "1.175" "1.125" "1.110" "651.4" "672.1" "683.9" "663.5" "708.2" "707.1" "704.3" "765.2" "732.5" "723.2" "" "" "" "" "" "" "" "" "" "" "523.2" "485.0" "543.3" "444.5" "489.8" "530.5" "493.1" "558.8" "732.5" "588.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3761626498643372027" "False" "High" "IsMasterProtein" "P05362" "Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2" "0.000" "False" "36.548" "14" "6" "6" "6" "532" "57.8" "7.99" "26.72" "6" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf03921, Pf13895, Pf21146" "3383" "ENSG00000090339" "ICAM1" "B2R6M3; hsa:3383; P05362; Q5NKV7; Q96B50" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling; miRNA role in immune response in sepsis; Platelet-mediated interactions with vascular and circulating cells; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Urotensin-II-mediated signaling pathway; Role of ROS in COVID-19 endothelial dysfunction; IL-26 signaling pathways; Type II interferon signaling" "27" "0" "1.114" "0.922" "1.127" "1.206" "1.133" "1.359" "1.088" "1.203" "1.130" "560.5" "624.2" "516.5" "631.4" "675.9" "634.9" "761.6" "609.8" "674.1" "633.5" "" "" "" "" "" "" "" "" "" "" "450.2" "450.4" "410.3" "423.0" "467.5" "476.3" "533.2" "445.3" "674.1" "515.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3786369172385558853" "False" "High" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "0.000" "False" "36.516" "34" "7" "11" "7" "210" "24.5" "5.95" "33.46" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "1.008" "1.008" "1.070" "1.019" "0.934" "0.979" "1.005" "1.005" "0.985" "1122.2" "1130.9" "1130.9" "1200.8" "1143.4" "1048.3" "1099.1" "1127.4" "1127.3" "1105.0" "" "" "" "" "" "" "" "" "" "" "901.4" "816.0" "898.3" "804.5" "790.8" "786.5" "769.6" "823.4" "1127.3" "898.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-849081801659546262" "False" "High" "IsMasterProtein" "P30533" "Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1" "0.000" "False" "36.498" "24" "8" "9" "8" "357" "41.4" "8.78" "34.00" "8" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06400, Pf06401" "4043" "ENSG00000163956" "LRPAP1" "D3DVR9; hsa:4043; P30533; Q2M310; Q53HQ3; Q53HS6" "" "Cholesterol metabolism" "1" "0" "0.994" "0.919" "1.065" "1.002" "0.956" "1.227" "1.154" "1.091" "1.005" "612.9" "609.3" "563.3" "652.7" "613.9" "585.7" "752.2" "707.1" "668.6" "615.7" "" "" "" "" "" "" "" "" "" "" "492.3" "439.6" "447.5" "437.3" "424.6" "439.5" "526.7" "516.4" "668.6" "500.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403678717829717744" "False" "High" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2B PE=1 SV=1" "0.000" "False" "36.470" "70" "5" "13" "5" "86" "10.1" "6.52" "52.91" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "0" "1.058" "0.998" "0.979" "1.010" "1.043" "0.988" "0.960" "1.030" "1.019" "1053.7" "1114.4" "1051.3" "1031.5" "1064.6" "1099.5" "1041.6" "1011.7" "1085.4" "1074.1" "" "" "" "" "" "" "" "" "" "" "846.3" "804.1" "835.1" "691.1" "736.3" "825.0" "729.3" "738.8" "1085.4" "873.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000966759959030184" "False" "High" "IsMasterProtein" "Q9H267" "Vacuolar protein sorting-associated protein 33B OS=Homo sapiens OX=9606 GN=VPS33B PE=1 SV=2" "0.000" "False" "36.461" "14" "9" "11" "9" "617" "70.5" "6.71" "35.94" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "26276" "ENSG00000184056" "VPS33B" "B3KQF6; hsa:26276; Q96K14; Q9H267; Q9NRP6; Q9NSF3" "Prevention of phagosomal-lysosomal fusion; SARS-CoV-2 modulates autophagy" "" "2" "0" "1.038" "1.015" "0.990" "0.964" "0.972" "0.976" "0.937" "0.968" "0.968" "659.8" "684.8" "669.8" "653.3" "636.2" "641.2" "643.8" "618.0" "638.4" "638.6" "" "" "" "" "" "" "" "" "" "" "530.0" "494.1" "532.1" "437.7" "440.0" "481.1" "450.8" "451.3" "638.4" "519.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850639355088799918" "False" "High" "IsMasterProtein" "Q96FI4" "Endonuclease 8-like 1 OS=Homo sapiens OX=9606 GN=NEIL1 PE=1 SV=3" "0.000" "False" "36.434" "23" "8" "10" "8" "390" "43.7" "9.92" "28.75" "8" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01149, Pf09292" "79661" "ENSG00000140398" "NEIL1" "D3DW75; hsa:79661; Q6ZRA7; Q86XW7; Q96FI4; Q9H6C3" "Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective Base Excision Repair Associated with NEIL1" "" "4" "0" "1.036" "1.011" "0.991" "1.061" "1.059" "0.968" "0.927" "1.018" "1.023" "804.5" "833.7" "813.5" "797.2" "853.4" "851.7" "778.9" "745.8" "818.7" "823.0" "" "" "" "" "" "" "" "" "" "" "646.2" "601.6" "646.2" "534.2" "590.2" "639.0" "545.4" "544.6" "818.7" "669.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1415915778275113183" "False" "High" "IsMasterProtein" "Q7L273" "BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens OX=9606 GN=KCTD9 PE=1 SV=1" "0.000" "False" "36.426" "25" "7" "8" "7" "389" "42.5" "6.37" "26.47" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction" "" "other molecular function" "Pf00805, Pf02214, Pf11834" "54793" "ENSG00000104756" "KCTD9" "hsa:54793; Q6NUM8; Q7L273; Q9NXV4" "" "" "0" "0" "1.009" "0.977" "1.025" "1.018" "0.958" "0.968" "1.029" "1.061" "1.019" "667.3" "673.3" "651.9" "684.1" "679.5" "639.2" "646.0" "687.0" "708.3" "679.8" "" "" "" "" "" "" "" "" "" "" "536.0" "485.8" "517.8" "458.3" "470.0" "479.6" "452.3" "501.7" "708.3" "552.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-901968503932970653" "False" "High" "IsMasterProtein" "Q9P2N6" "KAT8 regulatory NSL complex subunit 3 OS=Homo sapiens OX=9606 GN=KANSL3 PE=1 SV=2" "0.000" "False" "36.406" "8" "6" "7" "6" "904" "95.9" "9.39" "27.25" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf20408" "55683" "ENSG00000114982" "KANSL3" "A1L184; D3DXH3; D3DXH4; hsa:55683; Q05BU4; Q6P3X2; Q6PJH6; Q86T19; Q96L64; Q9H0C9; Q9H8C9; Q9HAP8; Q9NWE5; Q9P2N6" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2q11.2 copy number variation syndrome" "3" "0" "1.053" "1.037" "1.136" "1.050" "1.027" "1.083" "1.051" "1.037" "1.095" "374.8" "394.8" "388.6" "425.8" "393.6" "384.9" "405.7" "393.7" "388.8" "410.2" "" "" "" "" "" "" "" "" "" "" "301.0" "284.9" "308.7" "285.3" "272.3" "288.8" "284.1" "287.5" "388.8" "333.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858291838725637521" "False" "High" "IsMasterProtein" "Q14353" "Guanidinoacetate N-methyltransferase OS=Homo sapiens OX=9606 GN=GAMT PE=1 SV=1" "0.000" "False" "36.352" "20" "3" "7" "3" "236" "26.3" "6.14" "28.33" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "" "2593" "ENSG00000130005" "GAMT" "A8K0A0; hsa:2593; Q14353; Q53Y34; Q8WVJ1" "Transcriptional Regulation by MECP2; Creatine metabolism" "MECP2 and associated Rett syndrome; Creatine pathway" "4" "0" "1.166" "0.991" "1.171" "1.117" "1.012" "1.171" "1.107" "1.145" "1.030" "307.0" "357.9" "304.2" "359.4" "342.9" "310.6" "359.4" "339.9" "351.5" "316.2" "" "" "" "" "" "" "" "" "" "" "246.6" "258.2" "241.7" "240.8" "237.1" "233.0" "251.7" "248.2" "351.5" "257.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3684476333316036577" "False" "High" "IsMasterProtein" "Q5R372" "Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1" "0.000" "False" "36.326" "14" "9" "10" "9" "815" "92.5" "5.31" "30.29" "9" "transport;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00566, Pf00640, Pf12473" "9910" "ENSG00000152061" "RABGAP1L" "O75059; Q3ZTR8; Q5R369; Q5R372; Q8IVV0; Q8N921; Q8WV78; Q9NSP8; Q9UQ19; Q9UQP5; Q9Y6Y5; Q9Y6Y6" "" "" "0" "0" "0.987" "0.996" "1.022" "0.928" "0.939" "0.919" "0.941" "1.008" "1.004" "647.2" "638.7" "644.3" "661.5" "600.9" "607.9" "594.6" "609.3" "652.3" "649.5" "" "" "" "" "" "" "" "" "" "" "519.8" "460.9" "511.8" "443.2" "415.6" "456.1" "416.3" "445.0" "652.3" "528.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9192957103143993371" "False" "High" "IsMasterProtein" "Cont_Q9TTE1" "Serpin A3-1 OS=Bos taurus OX=9913 GN=SERPINA3-1 PE=1 SV=3" "0.000" "True" "36.325" "13" "5" "8" "4" "411" "46.2" "5.99" "30.18" "5" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "286804" "" "SERPINA3-1" "bta:286804; Q2KIQ9; Q3ZEJ7; Q9TTE1" "" "" "0" "0" "0.862" "0.788" "0.930" "0.841" "0.868" "1.503" "0.766" "0.782" "0.962" "334.2" "288.0" "263.4" "310.8" "281.0" "290.0" "502.1" "255.9" "261.4" "321.5" "" "" "" "" "" "" "" "" "" "" "268.4" "207.8" "209.2" "208.2" "194.4" "217.6" "351.6" "186.9" "261.4" "261.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146278248105171304" "False" "High" "IsMasterProtein" "Q6SJ93" "Serine protease FAM111B OS=Homo sapiens OX=9606 GN=FAM111B PE=1 SV=1" "0.000" "False" "36.318" "13" "9" "10" "8" "734" "84.6" "8.59" "33.58" "9" "protein metabolism;DNA metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf13365" "374393" "ENSG00000189057" "FAM111B" "B4E2G2; hsa:374393; Q6P661; Q6SJ93" "" "" "0" "0" "0.926" "1.007" "1.123" "1.041" "1.056" "1.294" "1.344" "1.514" "1.100" "275.5" "255.2" "277.5" "309.4" "286.7" "291.0" "356.4" "370.3" "417.3" "303.2" "" "" "" "" "" "" "" "" "" "" "221.3" "184.2" "220.4" "207.3" "198.3" "218.4" "249.5" "270.4" "417.3" "246.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4088167174397650062" "False" "High" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "0.000" "False" "36.264" "31" "9" "9" "9" "369" "39.1" "6.30" "28.50" "9" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "0.983" "1.025" "1.021" "0.987" "1.042" "1.082" "1.139" "1.065" "1.005" "668.4" "657.1" "685.5" "682.2" "659.7" "696.7" "723.5" "761.3" "711.9" "671.8" "" "" "" "" "" "" "" "" "" "" "536.9" "474.1" "544.5" "457.0" "456.3" "522.7" "506.6" "556.0" "711.9" "546.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1552754402547085825" "False" "High" "IsMasterProtein" "Q5MIZ7" "Serine/threonine-protein phosphatase 4 regulatory subunit 3B OS=Homo sapiens OX=9606 GN=PPP4R3B PE=1 SV=2" "0.000" "False" "36.251" "8" "5" "7" "2" "849" "97.4" "4.96" "26.40" "5" "other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "57223" "ENSG00000275052" "PPP4R3B" "hsa:57223; Q5MIZ7; Q6P9B0; Q86XB8; Q9BQJ0; Q9BRK2; Q9H913; Q9P2G0" "" "16p11.2 proximal deletion syndrome" "1" "0" "1.048" "1.124" "1.067" "1.000" "1.048" "0.976" "1.048" "1.098" "1.179" "149.5" "156.7" "168.0" "159.5" "149.5" "156.7" "146.0" "156.7" "164.2" "176.2" "" "" "" "" "" "" "" "" "" "" "120.1" "113.1" "133.4" "106.9" "103.4" "117.6" "102.2" "114.4" "164.2" "143.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9115702628811982031" "False" "High" "IsMasterProtein" "Q8N5A5" "Zinc finger CCCH-type with G patch domain-containing protein OS=Homo sapiens OX=9606 GN=ZGPAT PE=1 SV=3" "0.000" "False" "36.217" "19" "9" "10" "9" "531" "57.3" "5.43" "32.21" "9" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf18044" "84619" "ENSG00000197114" "ZGPAT" "E1P5K1; hsa:84619; Q4VXN9; Q5JWI9; Q5JWJ0; Q8N5A5; Q8NC55; Q8WUV4; Q96JI0; Q96JU4; Q9H401" "" "" "0" "0" "0.939" "0.919" "1.012" "0.967" "0.943" "1.018" "0.911" "0.956" "0.992" "496.1" "466.0" "455.7" "501.9" "479.7" "467.7" "505.2" "451.8" "474.3" "492.1" "" "" "" "" "" "" "" "" "" "" "398.5" "336.2" "362.0" "336.3" "331.7" "350.9" "353.7" "329.9" "474.3" "400.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3705334322242747100" "False" "High" "IsMasterProtein" "Q12788" "Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2" "0.000" "False" "36.216" "10" "6" "8" "6" "808" "89.0" "6.90" "25.03" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf08625" "10607" "ENSG00000183751; ENSG00000291938" "TBL3" "hsa:10607; Q12788; Q59GD6; Q8IVB7; Q96A78" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.919" "1.077" "1.310" "1.098" "1.066" "1.130" "1.052" "1.112" "1.013" "164.1" "150.9" "176.8" "215.1" "180.2" "175.0" "185.4" "172.6" "182.5" "166.2" "" "" "" "" "" "" "" "" "" "" "131.8" "108.9" "140.5" "144.1" "124.6" "131.3" "129.8" "126.0" "182.5" "135.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5929165091375925329" "False" "High" "IsMasterProtein" "Q15545" "Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1" "0.000" "False" "36.196" "23" "7" "10" "7" "349" "40.2" "5.20" "35.71" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04658" "6879" "ENSG00000178913" "TAF7" "B2RBV9; hsa:6879; Q13036; Q15545" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "0.988" "0.960" "1.135" "0.996" "1.029" "0.927" "1.050" "0.977" "1.050" "299.5" "295.9" "287.4" "339.9" "298.4" "308.3" "277.6" "314.6" "292.6" "314.3" "" "" "" "" "" "" "" "" "" "" "240.5" "213.5" "228.3" "227.7" "206.4" "231.3" "194.4" "229.8" "292.6" "255.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230612763215460817" "False" "High" "IsMasterProtein" "Q99829" "Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1" "0.000" "False" "36.188" "15" "8" "12" "8" "537" "59.0" "5.83" "40.41" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf07002" "8904" "ENSG00000214078" "CPNE1" "E1P5Q4; hsa:8904; Q6IBL3; Q99829; Q9H243; Q9NTZ7" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "" "2" "0" "0.926" "0.936" "0.889" "0.917" "0.865" "0.828" "0.827" "0.852" "0.957" "1517.6" "1405.2" "1420.7" "1349.2" "1391.5" "1312.4" "1255.9" "1254.8" "1292.4" "1451.6" "" "" "" "" "" "" "" "" "" "" "1218.9" "1014.0" "1128.5" "904.0" "962.4" "984.7" "879.3" "916.4" "1292.4" "1180.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5860754846925802701" "False" "High" "IsMasterProtein" "O95400" "CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1" "0.000" "False" "36.105" "25" "6" "8" "6" "341" "37.6" "4.61" "27.91" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02213" "10421" "ENSG00000169217" "CD2BP2" "B2RDX2; hsa:10421; O95400; Q9ULP2" "" "mRNA processing; Ciliary landscape" "2" "0" "0.955" "1.058" "1.094" "0.939" "1.013" "1.029" "0.953" "1.035" "1.022" "546.8" "522.1" "578.3" "598.0" "513.7" "554.1" "562.4" "521.1" "565.7" "558.5" "" "" "" "" "" "" "" "" "" "" "439.2" "376.7" "459.4" "400.7" "355.3" "415.7" "393.8" "380.6" "565.7" "454.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910881260683280979" "False" "High" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "0.000" "False" "36.079" "24" "7" "10" "7" "299" "33.6" "4.81" "32.81" "7" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "1.040" "1.063" "1.114" "1.047" "1.037" "1.016" "0.997" "1.004" "1.013" "1314.5" "1367.3" "1397.6" "1464.9" "1376.4" "1362.7" "1335.0" "1310.3" "1319.4" "1331.7" "" "" "" "" "" "" "" "" "" "" "1055.8" "986.6" "1110.1" "981.5" "951.9" "1022.4" "934.7" "957.0" "1319.4" "1083.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2576467063852337379" "False" "High" "IsMasterProtein" "Q12912" "Inositol 1,4,5-triphosphate receptor associated 2 OS=Homo sapiens OX=9606 GN=IRAG2 PE=1 SV=3" "0.000" "False" "36.076" "18" "10" "15" "10" "555" "62.1" "5.85" "39.54" "10" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf05781" "4033" "ENSG00000118308" "IRAG2" "A0AVM2; B4E077; hsa:4033; Q12912; Q8N301" "Neutrophil degranulation" "" "1" "0" "0.993" "0.899" "0.935" "0.958" "0.940" "0.984" "0.986" "1.002" "0.972" "1004.9" "998.4" "903.8" "939.2" "962.8" "945.1" "989.1" "990.5" "1006.7" "976.7" "" "" "" "" "" "" "" "" "" "" "807.1" "720.4" "717.9" "629.3" "665.9" "709.1" "692.5" "723.4" "1006.7" "794.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8443695202608012138" "False" "High" "IsMasterProtein" "P49796" "Regulator of G-protein signaling 3 OS=Homo sapiens OX=9606 GN=RGS3 PE=1 SV=2" "0.000" "False" "36.073" "7" "8" "11" "8" "1198" "132.3" "6.28" "36.89" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00168, Pf00595, Pf00615" "5998" "ENSG00000138835" "RGS3" "A6NHA0; A8K0V1; B3KUB2; hsa:5998; P49796; Q5VXB8; Q5VXC1; Q5VZ05; Q5VZ06; Q6ZRM5; Q8IUQ1; Q8NC47; Q8NFN4; Q8NFN5; Q8NFN6; Q8TD59; Q8TD68; Q8WV02; Q8WXA0" "G alpha (q) signalling events; G alpha (i) signalling events" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "4" "0" "1.003" "0.999" "1.072" "1.061" "1.111" "1.113" "1.144" "1.062" "1.062" "620.8" "622.5" "620.2" "665.7" "658.3" "689.7" "691.0" "710.2" "659.4" "659.0" "" "" "" "" "" "" "" "" "" "" "498.6" "449.2" "492.7" "446.0" "455.3" "517.5" "483.8" "518.6" "659.4" "536.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8603881510889965526" "False" "High" "IsMasterProtein" "Q92889" "DNA repair endonuclease XPF OS=Homo sapiens OX=9606 GN=ERCC4 PE=1 SV=3" "0.000" "False" "35.988" "10" "9" "10" "9" "916" "104.4" "6.93" "33.25" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02732" "2072" "ENSG00000175595" "ERCC4" "A5PKV6; A8K111; hsa:2072; O00140; Q8TD83; Q92889" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "1.084" "0.966" "1.039" "1.073" "0.958" "1.007" "1.139" "1.067" "1.065" "339.3" "367.7" "327.7" "352.5" "364.1" "325.0" "341.8" "386.5" "362.1" "361.4" "" "" "" "" "" "" "" "" "" "" "272.5" "265.3" "260.3" "236.2" "251.8" "243.9" "239.3" "282.3" "362.1" "293.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1871023154594230453" "False" "High" "IsMasterProtein" "Q14241" "Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=3" "0.000" "False" "35.975" "11" "9" "12" "9" "772" "87.2" "9.57" "36.39" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06881, Pf08711" "6924" "ENSG00000011007" "ELOA" "B2R7Q8; hsa:6924; Q14241; Q8IXH1" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; 10q11.21q11.23 copy number variation syndrome" "14" "0" "1.082" "1.154" "1.121" "1.137" "1.127" "1.146" "1.154" "1.098" "1.080" "837.2" "906.1" "966.3" "938.6" "952.0" "943.4" "959.4" "965.9" "919.1" "904.1" "" "" "" "" "" "" "" "" "" "" "672.4" "653.8" "767.5" "628.9" "658.4" "707.8" "671.7" "705.4" "919.1" "735.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5130532040742567239" "False" "High" "IsMasterProtein" "Q9HCN8" "Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2" "0.000" "False" "35.961" "27" "5" "7" "5" "221" "23.6" "7.03" "27.61" "5" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02815" "23753" "ENSG00000128228" "SDF2L1" "A2RUD3; hsa:23753; Q9BRI5; Q9HCN8" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.964" "0.968" "1.041" "1.005" "0.974" "1.052" "1.050" "1.006" "1.030" "724.2" "698.2" "701.2" "754.3" "728.1" "705.1" "762.1" "760.8" "728.5" "746.3" "" "" "" "" "" "" "" "" "" "" "581.7" "503.8" "557.0" "505.4" "503.6" "529.0" "533.6" "555.6" "728.5" "606.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155444033397587021" "False" "High" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "0.000" "False" "35.952" "13" "5" "6" "5" "439" "48.9" "5.29" "23.43" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.006" "1.034" "1.104" "1.048" "1.083" "1.073" "1.081" "1.122" "1.053" "504.2" "507.2" "521.5" "556.7" "528.6" "546.2" "540.7" "545.0" "565.6" "530.8" "" "" "" "" "" "" "" "" "" "" "405.0" "366.0" "414.3" "373.0" "365.6" "409.8" "378.6" "398.0" "565.6" "431.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331162755834209068" "False" "High" "IsMasterProtein" "Q8IWR0" "Zinc finger CCCH domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZC3H7A PE=1 SV=1" "0.000" "False" "35.943" "8" "9" "10" "9" "971" "110.5" "7.30" "31.58" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642" "29066" "ENSG00000122299" "ZC3H7A" "D3DUG5; hsa:29066; Q8IWR0; Q9NPE9" "" "" "0" "0" "1.022" "0.997" "0.979" "1.031" "0.953" "0.898" "1.004" "0.993" "0.986" "569.7" "582.1" "567.8" "557.9" "587.3" "543.1" "511.9" "571.9" "565.8" "561.6" "" "" "" "" "" "" "" "" "" "" "457.6" "420.1" "451.0" "373.8" "406.2" "407.5" "358.4" "417.6" "565.8" "456.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658103532290025162" "False" "High" "IsMasterProtein" "P49770" "Translation initiation factor eIF2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "0.000" "False" "35.937" "29" "9" "15" "9" "351" "39.0" "6.16" "40.54" "9" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Recycling of eIF2:GDP" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome; Primary ovarian insufficiency" "5" "0" "1.026" "0.987" "1.032" "1.029" "0.962" "0.955" "0.941" "1.004" "0.937" "827.4" "849.1" "816.4" "853.6" "851.1" "796.0" "789.8" "778.5" "830.4" "775.6" "" "" "" "" "" "" "" "" "" "" "664.5" "612.7" "648.5" "571.9" "588.6" "597.2" "553.0" "568.5" "830.4" "630.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1681644365065118187" "False" "High" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "0.000" "False" "35.934" "20" "6" "7" "6" "390" "42.9" "8.72" "25.17" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; O95510; O95511; Q8IVS2" "Mitochondrial Fatty Acid Beta-Oxidation" "Mitochondrial fatty acid synthesis pathway" "2" "0" "0.989" "1.075" "0.990" "1.018" "1.003" "0.900" "1.011" "1.053" "1.019" "224.0" "221.7" "240.8" "221.8" "228.0" "224.7" "201.6" "226.4" "235.8" "228.3" "" "" "" "" "" "" "" "" "" "" "179.9" "159.9" "191.3" "148.6" "157.7" "168.6" "141.2" "165.4" "235.8" "185.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8048887560610190463" "False" "High" "IsMasterProtein" "Q5JPH6" "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial OS=Homo sapiens OX=9606 GN=EARS2 PE=1 SV=2" "0.000" "False" "35.932" "13" "7" "11" "7" "523" "58.7" "8.76" "31.67" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00749, Pf19269" "124454" "ENSG00000103356" "EARS2" "B3KTT2; D3DWF1; hsa:124454; Q5JPH6; Q86YH3; Q8TF31" "Mitochondrial tRNA aminoacylation" "" "1" "0" "0.973" "1.099" "1.046" "1.026" "1.019" "0.972" "1.007" "1.152" "0.972" "275.5" "268.2" "302.8" "288.2" "282.7" "280.7" "267.7" "277.4" "317.3" "267.8" "" "" "" "" "" "" "" "" "" "" "221.3" "193.5" "240.5" "193.1" "195.5" "210.6" "187.4" "202.6" "317.3" "217.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1907773996049463670" "False" "High" "IsMasterProtein" "O43504" "Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1" "0.000" "False" "35.894" "55" "3" "5" "3" "91" "9.6" "4.87" "26.62" "3" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf16672" "10542" "ENSG00000134248" "LAMTOR5" "A0A0C4DGV4; hsa:10542; O43504; Q6IBD8" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "" "7" "0" "1.091" "1.091" "1.160" "1.076" "1.151" "1.071" "1.091" "1.019" "1.111" "476.1" "519.6" "519.7" "552.2" "512.5" "548.2" "509.9" "519.7" "485.0" "528.8" "" "" "" "" "" "" "" "" "" "" "382.4" "374.9" "412.8" "370.0" "354.4" "411.3" "357.0" "379.5" "485.0" "430.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3969710029576412220" "False" "High" "IsMasterProtein" "Q9Y3T6" "R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3" "0.000" "False" "35.891" "18" "6" "6" "6" "440" "49.1" "5.63" "26.94" "6" "" "" "nucleic acid binding activity" "Pf01424" "203069" "ENSG00000104679" "R3HCC1" "B7ZLI1; hsa:203069; Q9Y3T6" "" "" "0" "0" "1.045" "1.141" "1.003" "1.137" "1.078" "1.079" "1.111" "1.126" "1.190" "185.7" "194.1" "212.0" "186.2" "211.1" "200.1" "200.5" "206.4" "209.1" "221.1" "" "" "" "" "" "" "" "" "" "" "149.2" "140.1" "168.4" "124.8" "146.0" "150.2" "140.4" "150.8" "209.1" "179.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6811152372553307115" "False" "High" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "0.000" "False" "35.864" "16" "7" "10" "7" "529" "59.5" "8.92" "26.35" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "" "3" "0" "1.066" "1.094" "1.085" "1.058" "1.034" "1.101" "1.204" "1.151" "1.081" "1249.2" "1332.0" "1366.9" "1355.4" "1321.5" "1292.1" "1375.5" "1504.7" "1437.4" "1350.1" "" "" "" "" "" "" "" "" "" "" "1003.4" "961.1" "1085.7" "908.1" "914.0" "969.4" "963.0" "1098.9" "1437.4" "1097.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3301543360737881129" "False" "High" "IsMasterProtein" "Q9Y281" "Cofilin-2 OS=Homo sapiens OX=9606 GN=CFL2 PE=1 SV=1" "0.000" "False" "35.848" "39" "6" "22" "5" "166" "18.7" "7.88" "78.18" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1073" "ENSG00000165410" "CFL2" "G3V5P4; hsa:1073; Q9Y281" "" "Leptin signaling pathway; Microtubule cytoskeleton regulation; Regulation of actin cytoskeleton; G13 signaling pathway" "4" "0" "0.987" "0.997" "1.013" "0.958" "1.009" "0.951" "0.955" "0.957" "0.924" "355.5" "351.0" "354.5" "360.2" "340.6" "358.7" "338.1" "339.5" "340.4" "328.4" "" "" "" "" "" "" "" "" "" "" "285.5" "253.3" "281.6" "241.3" "235.5" "269.1" "236.7" "247.9" "340.4" "267.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140378452823337742" "False" "High" "IsMasterProtein" "Q9HCN4" "GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1" "0.000" "False" "35.827" "18" "5" "8" "5" "374" "41.7" "4.92" "29.32" "5" "" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03029" "11321" "ENSG00000198522" "GPN1" "B4DQJ5; B4DQM4; B4DXU4; B5MBZ5; hsa:11321; O76004; Q9HCN4" "" "" "0" "0" "0.959" "0.955" "1.012" "0.948" "1.018" "1.088" "0.938" "0.991" "0.928" "349.7" "335.5" "334.1" "354.1" "331.6" "356.1" "380.4" "328.0" "346.6" "324.5" "" "" "" "" "" "" "" "" "" "" "280.9" "242.1" "265.4" "237.2" "229.3" "267.2" "266.4" "239.6" "346.6" "263.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "718795190937465911" "False" "High" "IsMasterProtein" "Q9Y6V7" "Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1" "0.000" "False" "35.813" "19" "9" "10" "8" "483" "54.2" "9.06" "30.68" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "54555" "ENSG00000105671" "DDX49" "E7ENA0; hsa:54555; Q53FJ1; Q9BVQ8; Q9Y6V7" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.873" "0.977" "0.997" "1.179" "1.120" "1.206" "1.281" "1.131" "1.163" "634.1" "553.5" "619.4" "631.9" "747.4" "710.5" "764.8" "812.2" "716.9" "737.6" "" "" "" "" "" "" "" "" "" "" "509.3" "399.4" "492.0" "423.4" "516.9" "533.0" "535.4" "593.2" "716.9" "599.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4523717261131920154" "False" "High" "IsMasterProtein" "Q8NEZ4" "Histone-lysine N-methyltransferase 2C OS=Homo sapiens OX=9606 GN=KMT2C PE=1 SV=3" "0.000" "False" "35.807" "2" "10" "10" "10" "4911" "541.0" "6.49" "25.84" "10" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "58508" "ENSG00000055609" "KMT2C" "hsa:58508; Q8NC02; Q8NDF6; Q8NEZ4; Q9H9P4; Q9NR13; Q9P222; Q9UDR7" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines" "Histone modifications; Pathways affected in adenoid cystic carcinoma; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; Kleefstra syndrome" "9" "0" "1.117" "0.867" "0.900" "1.064" "0.959" "1.014" "1.060" "0.879" "0.891" "77.4" "86.4" "67.1" "69.6" "82.3" "74.2" "78.4" "82.0" "68.0" "68.9" "" "" "" "" "" "" "" "" "" "" "62.1" "62.3" "53.3" "46.6" "56.9" "55.7" "54.9" "59.9" "68.0" "56.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890760883318771042" "False" "High" "IsMasterProtein" "Q15653" "NF-kappa-B inhibitor beta OS=Homo sapiens OX=9606 GN=NFKBIB PE=1 SV=2" "0.000" "False" "35.774" "22" "6" "7" "6" "356" "37.7" "4.84" "24.25" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00023, Pf13637" "4793" "ENSG00000104825; ENSG00000282905" "NFKBIB" "A8K3F4; hsa:4793; Q15653; Q96BJ7" "Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "IL-1 signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; TNF-alpha signaling pathway; Apoptosis; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Toll-like receptor signaling pathway" "16" "0" "1.021" "0.932" "0.923" "0.991" "0.967" "0.904" "0.957" "0.905" "0.978" "605.1" "618.0" "564.2" "558.2" "599.3" "585.3" "547.1" "579.1" "547.7" "591.5" "" "" "" "" "" "" "" "" "" "" "486.0" "446.0" "448.1" "374.0" "414.5" "439.1" "383.1" "422.9" "547.7" "481.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6381027269296732412" "False" "High" "IsMasterProtein" "Q7Z392" "Trafficking protein particle complex subunit 11 OS=Homo sapiens OX=9606 GN=TRAPPC11 PE=1 SV=2" "0.000" "False" "35.696" "9" "10" "10" "10" "1133" "128.8" "7.14" "30.94" "10" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "" "Pf11817, Pf12742" "60684" "ENSG00000168538" "TRAPPC11" "A4QPB8; B2RCD6; hsa:60684; Q5U5I7; Q6FI73; Q7Z392; Q86T25; Q9H0L1; Q9H5K9; Q9H8Q1; Q9H9I7" "RAB GEFs exchange GTP for GDP on RABs" "Genes related to primary cilium development (based on CRISPR)" "2" "0" "0.986" "1.000" "1.022" "1.033" "0.985" "1.035" "1.008" "0.967" "1.049" "577.5" "569.5" "577.4" "590.0" "596.7" "568.6" "597.9" "582.1" "558.4" "605.6" "" "" "" "" "" "" "" "" "" "" "463.9" "411.0" "458.6" "395.3" "412.7" "426.6" "418.6" "425.1" "558.4" "492.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7841395992400372766" "False" "High" "IsMasterProtein" "Q9NVG8" "TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3" "0.000" "False" "35.679" "23" "8" "10" "8" "400" "46.5" "5.24" "40.07" "8" "transport" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00566" "54662" "ENSG00000107021" "TBC1D13" "A7E2E7; B3KW04; B9EGJ8; hsa:54662; Q5T270; Q5T271; Q9NVG8" "TBC/RABGAPs" "" "1" "0" "1.006" "0.974" "1.027" "1.069" "1.016" "0.996" "0.995" "0.994" "1.033" "1081.5" "1087.7" "1053.3" "1110.5" "1155.9" "1099.1" "1077.2" "1076.2" "1074.7" "1117.3" "" "" "" "" "" "" "" "" "" "" "868.6" "784.8" "836.7" "744.0" "799.4" "824.6" "754.2" "786.0" "1074.7" "908.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "978357741075337008" "False" "High" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "0.000" "False" "35.664" "16" "6" "9" "6" "594" "66.5" "5.59" "30.60" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "" "6" "0" "0.995" "0.986" "1.064" "1.111" "0.970" "0.959" "1.072" "1.036" "1.027" "462.6" "460.5" "455.9" "492.2" "513.8" "448.9" "443.9" "495.7" "479.5" "475.3" "" "" "" "" "" "" "" "" "" "" "371.6" "332.3" "362.2" "329.7" "355.4" "336.8" "310.8" "362.0" "479.5" "386.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108137657648573585" "False" "High" "IsMasterProtein" "O95571" "Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2" "0.000" "False" "35.637" "25" "5" "8" "5" "254" "27.9" "6.83" "25.37" "5" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00753" "23474" "ENSG00000105755" "ETHE1" "hsa:23474; O95571; Q96HR0; Q9H001" "Sulfide oxidation to sulfate" "" "1" "0" "1.016" "1.050" "0.998" "1.037" "1.010" "1.049" "1.085" "0.960" "0.989" "455.5" "463.0" "478.3" "454.5" "472.3" "460.1" "477.6" "494.2" "437.3" "450.6" "" "" "" "" "" "" "" "" "" "" "365.9" "334.1" "380.0" "304.5" "326.6" "345.2" "334.4" "360.9" "437.3" "366.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4003826422992493976" "False" "High" "IsMasterProtein" "Q9Y3D0" "Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1" "0.000" "False" "35.538" "44" "4" "4" "4" "163" "17.7" "5.19" "22.22" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01883" "51647" "ENSG00000166595" "CIAO2B" "hsa:51647; Q9Y3D0" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis; 2q11.2 copy number variation syndrome" "3" "0" "1.080" "1.004" "1.122" "1.079" "0.919" "0.962" "0.965" "0.883" "1.041" "214.6" "231.7" "215.4" "240.7" "231.5" "197.2" "206.3" "207.1" "189.6" "223.4" "" "" "" "" "" "" "" "" "" "" "172.3" "167.2" "171.1" "161.3" "160.1" "148.0" "144.4" "151.2" "189.6" "181.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4381387929152042020" "False" "High" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "0.000" "False" "35.531" "22" "9" "9" "9" "412" "46.6" "7.18" "31.38" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.963" "1.000" "1.020" "1.040" "1.004" "1.036" "1.095" "1.059" "1.025" "1104.8" "1064.0" "1104.3" "1126.4" "1148.6" "1109.6" "1144.7" "1209.9" "1170.5" "1132.6" "" "" "" "" "" "" "" "" "" "" "887.3" "767.7" "877.2" "754.7" "794.4" "832.5" "801.5" "883.6" "1170.5" "921.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646887584104105884" "False" "High" "IsMasterProtein" "Q9BW61" "DET1- and DDB1-associated protein 1 OS=Homo sapiens OX=9606 GN=DDA1 PE=1 SV=1" "0.000" "False" "35.495" "45" "5" "9" "5" "102" "11.8" "8.68" "30.86" "5" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10172" "79016" "ENSG00000130311" "DDA1" "hsa:79016; Q9BW61" "Neddylation" "" "1" "0" "1.022" "1.041" "1.019" "1.003" "1.026" "0.942" "0.991" "1.008" "0.997" "649.8" "664.2" "676.5" "661.9" "651.8" "666.9" "612.3" "644.1" "655.1" "647.6" "" "" "" "" "" "" "" "" "" "" "521.9" "479.3" "537.4" "443.4" "450.8" "500.4" "428.7" "470.4" "655.1" "526.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5558821625919889641" "False" "High" "IsMasterProtein" "Q9UDY4" "DnaJ homolog subfamily B member 4 OS=Homo sapiens OX=9606 GN=DNAJB4 PE=1 SV=1" "0.000" "False" "35.471" "15" "4" "7" "3" "337" "37.8" "8.50" "25.16" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00226, Pf01556" "11080" "ENSG00000162616" "DNAJB4" "B2R824; hsa:11080; Q13431; Q9UDY4" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.052" "1.057" "1.105" "1.069" "1.142" "1.026" "1.039" "1.236" "1.111" "349.6" "367.8" "369.6" "386.2" "373.6" "399.1" "358.8" "363.3" "432.0" "388.5" "" "" "" "" "" "" "" "" "" "" "280.8" "265.4" "293.6" "258.7" "258.4" "299.4" "251.2" "265.4" "432.0" "315.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014625147701874173" "False" "High" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "0.000" "False" "35.447" "14" "8" "11" "8" "578" "65.5" "8.21" "38.69" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.167" "1.080" "1.052" "1.128" "1.112" "0.981" "0.970" "1.067" "1.038" "534.4" "623.4" "577.3" "562.3" "602.8" "594.0" "524.3" "518.5" "570.1" "554.6" "" "" "" "" "" "" "" "" "" "" "429.2" "449.9" "458.6" "376.8" "416.9" "445.6" "367.1" "378.7" "570.1" "451.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4731047404195791293" "False" "High" "IsMasterProtein" "Q8IXW5" "Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 OS=Homo sapiens OX=9606 GN=RPAP2 PE=1 SV=1" "0.000" "False" "35.425" "13" "7" "8" "7" "612" "69.5" "7.78" "25.39" "7" "RNA metabolism OR transcription;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04181" "79871" "ENSG00000122484" "RPAP2" "C9JKB5; hsa:79871; Q49AS7; Q8IXW5; Q9H8Y2" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.040" "0.941" "0.895" "1.027" "0.957" "0.874" "1.076" "1.112" "0.968" "204.6" "212.9" "192.6" "183.2" "210.1" "195.8" "178.7" "220.2" "227.4" "198.1" "" "" "" "" "" "" "" "" "" "" "164.3" "153.6" "153.0" "122.7" "145.3" "146.9" "125.1" "160.8" "227.4" "161.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299330729239778052" "False" "High" "IsMasterProtein" "Q6PFW1" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=PPIP5K1 PE=1 SV=1" "0.000" "False" "35.410" "8" "11" "12" "4" "1433" "159.4" "5.40" "33.91" "11" "other metabolic processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "9677" "ENSG00000168781" "PPIP5K1" "hsa:9677; O15082; Q5HYF8; Q6PFW1; Q7Z3A7; Q86TE7; Q86UV3; Q86UV4; Q86XW8; Q8IZN0" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "1.025" "0.890" "1.162" "1.043" "1.011" "0.941" "0.877" "0.986" "1.073" "160.3" "164.4" "142.6" "186.3" "167.2" "162.1" "150.9" "140.6" "158.1" "172.0" "" "" "" "" "" "" "" "" "" "" "128.8" "118.6" "113.3" "124.8" "115.6" "121.6" "105.7" "102.7" "158.1" "139.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9103143806185528671" "False" "High" "IsMasterProtein" "Q86UA1" "Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3" "0.000" "False" "35.399" "13" "8" "13" "8" "669" "78.4" "5.40" "40.32" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "" "55015" "ENSG00000185246" "PRPF39" "hsa:55015; Q08AL1; Q08AL2; Q86UA1; Q9NUU5" "" "" "0" "0" "1.004" "0.881" "1.064" "1.013" "0.955" "0.979" "1.064" "0.953" "0.989" "352.6" "354.2" "310.6" "375.1" "357.0" "336.6" "345.1" "375.2" "335.9" "348.9" "" "" "" "" "" "" "" "" "" "" "283.2" "255.5" "246.7" "251.3" "246.9" "252.6" "241.6" "274.0" "335.9" "283.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361543221458196950" "False" "High" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "0.000" "False" "35.363" "25" "9" "9" "9" "372" "41.9" "7.31" "30.26" "9" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "GDP-fucose biosynthesis" "" "1" "0" "0.973" "1.041" "1.103" "1.058" "1.078" "1.135" "1.046" "1.002" "1.057" "684.6" "666.0" "712.6" "755.1" "724.3" "738.0" "776.8" "716.2" "686.2" "723.5" "" "" "" "" "" "" "" "" "" "" "549.9" "480.6" "566.0" "505.9" "500.9" "553.7" "543.8" "523.1" "686.2" "588.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966374980505742475" "False" "High" "IsMasterProtein" "Q15047" "Histone-lysine N-methyltransferase SETDB1 OS=Homo sapiens OX=9606 GN=SETDB1 PE=1 SV=1" "0.000" "False" "35.342" "7" "9" "13" "9" "1291" "143.1" "6.02" "39.51" "9" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01429, Pf05033, Pf18300, Pf18358, Pf18359" "9869" "ENSG00000143379" "SETDB1" "A6NEW2; hsa:9869; Q15047; Q5SZD8; Q5SZD9; Q5SZE0; Q5SZE7; Q96GM9" "PKMTs methylate histone lysines" "Histone modifications; Pleural mesothelioma" "3" "0" "0.990" "0.961" "1.098" "1.018" "0.916" "1.011" "0.932" "0.938" "0.952" "707.0" "699.7" "679.6" "776.2" "719.8" "647.4" "714.8" "659.0" "663.1" "672.8" "" "" "" "" "" "" "" "" "" "" "567.9" "504.9" "539.8" "520.1" "497.8" "485.7" "500.4" "481.3" "663.1" "547.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3312961601966625911" "False" "High" "IsMasterProtein" "Q96EY8" "Corrinoid adenosyltransferase MMAB OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1" "0.000" "False" "35.326" "29" "6" "9" "6" "250" "27.4" "8.60" "30.87" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01923" "326625" "ENSG00000139428" "MMAB" "C5HU05; hsa:326625; Q96EY8; Q9BSH0" "Cobalamin (Cbl) metabolism; Defective MMAB causes MMA, cblB type" "Vitamin B12 metabolism" "3" "0" "0.983" "1.000" "0.958" "0.914" "0.988" "0.918" "0.876" "0.978" "0.950" "800.7" "787.2" "800.9" "767.3" "731.9" "790.9" "734.9" "701.4" "782.9" "760.9" "" "" "" "" "" "" "" "" "" "" "643.1" "568.0" "636.2" "514.1" "506.2" "593.4" "514.5" "512.2" "782.9" "618.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792306396308701389" "False" "High" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "0.000" "False" "35.316" "7" "6" "7" "6" "955" "108.6" "10.15" "26.10" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "Interactome of polycomb repressive complex 2 (PRC2)" "3" "0" "0.948" "1.097" "1.075" "0.987" "1.054" "1.186" "1.188" "1.190" "1.096" "575.0" "545.0" "630.5" "618.0" "567.7" "606.1" "682.2" "683.2" "684.2" "630.0" "" "" "" "" "" "" "" "" "" "" "461.8" "393.3" "500.8" "414.1" "392.6" "454.7" "477.7" "498.9" "684.2" "512.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9074819377594512916" "False" "High" "IsMasterProtein" "Q9BQ67" "Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1" "0.000" "False" "35.293" "17" "5" "6" "5" "446" "49.4" "4.92" "24.51" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "83743" "ENSG00000105447" "GRWD1" "A0MNN5; hsa:83743; Q8TF59; Q9BQ67" "" "" "0" "0" "1.073" "1.125" "1.116" "1.142" "1.084" "1.058" "1.132" "1.095" "1.035" "391.0" "419.7" "440.0" "436.6" "446.4" "423.7" "413.8" "442.6" "428.3" "404.5" "" "" "" "" "" "" "" "" "" "" "314.1" "302.9" "349.5" "292.5" "308.7" "317.9" "289.7" "323.3" "428.3" "329.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6656067604424276740" "False" "High" "IsMasterProtein" "O95365" "Zinc finger and BTB domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZBTB7A PE=1 SV=1" "0.000" "False" "35.263" "14" "4" "4" "4" "584" "61.4" "5.19" "20.41" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "51341" "ENSG00000178951" "ZBTB7A" "D6W619; hsa:51341; O00456; O95365; Q14D41; Q5XG86" "" "IL-18 signaling pathway" "1" "0" "1.195" "1.200" "1.377" "1.146" "1.157" "1.203" "1.316" "1.311" "1.128" "82.7" "98.8" "99.2" "113.9" "94.8" "95.7" "99.4" "108.8" "108.4" "93.3" "" "" "" "" "" "" "" "" "" "" "66.4" "71.3" "78.8" "76.3" "65.5" "71.8" "69.6" "79.5" "108.4" "75.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716133539155154712" "False" "High" "IsMasterProtein" "P82650" "Small ribosomal subunit protein mS22 OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" "0.000" "False" "35.234" "21" "9" "11" "9" "360" "41.3" "7.90" "36.12" "9" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10245" "56945" "ENSG00000175110" "MRPS22" "hsa:56945; P82650; Q9H3I1" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Primary ovarian insufficiency" "4" "0" "1.052" "1.044" "0.942" "0.956" "0.961" "0.901" "1.029" "1.022" "0.993" "672.9" "707.8" "702.7" "634.2" "643.2" "646.4" "606.0" "692.4" "687.5" "667.9" "" "" "" "" "" "" "" "" "" "" "540.5" "510.7" "558.2" "424.9" "444.8" "485.0" "424.3" "505.7" "687.5" "543.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6044339121918528105" "False" "High" "IsMasterProtein" "O75676" "Ribosomal protein S6 kinase alpha-4 OS=Homo sapiens OX=9606 GN=RPS6KA4 PE=1 SV=1" "0.000" "False" "35.228" "10" "8" "8" "7" "772" "85.6" "8.28" "25.40" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "8986" "ENSG00000162302" "RPS6KA4" "A8K7Z8; hsa:8986; O75585; O75676; Q53ES8" "Recycling pathway of L1" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "7" "0" "1.082" "0.998" "1.215" "1.132" "1.048" "1.064" "1.149" "1.223" "1.046" "414.0" "448.1" "413.3" "502.8" "468.5" "434.0" "440.4" "475.5" "506.2" "432.9" "" "" "" "" "" "" "" "" "" "" "332.5" "323.3" "328.3" "336.9" "324.0" "325.6" "308.4" "347.3" "506.2" "352.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6115802108714275107" "False" "High" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "0.000" "False" "35.210" "32" "6" "13" "6" "225" "25.0" "5.69" "40.77" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "6" "0" "0.999" "0.986" "0.997" "0.972" "0.943" "0.942" "0.963" "0.956" "1.001" "1116.5" "1115.6" "1101.5" "1113.4" "1085.8" "1052.6" "1052.1" "1075.0" "1067.8" "1117.9" "" "" "" "" "" "" "" "" "" "" "896.8" "805.0" "874.9" "746.0" "750.9" "789.7" "736.6" "785.1" "1067.8" "909.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7666744292030772641" "False" "High" "IsMasterProtein" "Q9BRK5" "45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1" "0.000" "False" "35.203" "13" "4" "8" "4" "362" "41.8" "4.86" "31.03" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "51150" "" "SDF4" "B1AME5; B1AME6; B2RDF1; B4DSM1; hsa:51150; Q53G52; Q53HQ9; Q8NBQ3; Q96AA1; Q9BRK5; Q9NZP7; Q9UN53" "" "" "0" "0" "1.016" "0.971" "1.123" "1.111" "1.075" "1.154" "1.182" "1.120" "1.041" "1055.5" "1071.9" "1025.2" "1185.4" "1172.8" "1134.4" "1218.5" "1247.8" "1182.2" "1098.8" "" "" "" "" "" "" "" "" "" "" "847.8" "773.5" "814.3" "794.2" "811.1" "851.1" "853.1" "911.2" "1182.2" "893.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1635055545262344476" "False" "High" "IsMasterProtein" "Q9UER7" "Death domain-associated protein 6 OS=Homo sapiens OX=9606 GN=DAXX PE=1 SV=2" "0.000" "False" "35.145" "9" "4" "5" "4" "740" "81.3" "4.87" "23.88" "4" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03344, Pf20920" "1616" "ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617" "DAXX" "B4E1I3; F5ANJ6; F5ANJ7; F5H082; hsa:1616; O14747; O15141; O15208; Q5STK9; Q9BWI3; Q9UER7" "SUMOylation of transcription cofactors; HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway" "11" "0" "1.041" "0.933" "1.034" "0.980" "1.103" "0.977" "0.985" "1.041" "0.989" "250.5" "260.8" "233.6" "258.9" "245.5" "276.2" "244.7" "246.8" "260.8" "247.7" "" "" "" "" "" "" "" "" "" "" "201.2" "188.2" "185.6" "173.4" "169.8" "207.2" "171.3" "180.3" "260.8" "201.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3711449830735196489" "False" "High" "IsMasterProtein" "Q9BZJ0" "Crooked neck-like protein 1 OS=Homo sapiens OX=9606 GN=CRNKL1 PE=1 SV=4" "0.000" "False" "35.123" "10" "9" "10" "9" "848" "100.4" "8.00" "31.50" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf02184" "51340" "ENSG00000101343" "CRNKL1" "A8K9T4; hsa:51340; Q5JY64; Q8WYI5; Q9BZI9; Q9BZJ0; Q9BZJ1; Q9BZJ2; Q9GZW7; Q9H8F8; Q9NQH5; Q9NYD8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.002" "1.023" "1.113" "0.943" "0.992" "1.062" "0.928" "0.982" "1.055" "541.1" "542.0" "553.3" "602.4" "510.3" "536.6" "574.7" "502.2" "531.5" "570.8" "" "" "" "" "" "" "" "" "" "" "434.6" "391.1" "439.5" "403.6" "353.0" "402.6" "402.4" "366.8" "531.5" "464.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-145222249138625553" "False" "High" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "0.000" "False" "35.110" "34" "9" "13" "9" "293" "34.2" "9.88" "40.49" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "1.005" "1.028" "0.983" "1.070" "1.097" "1.007" "1.104" "1.092" "1.068" "870.6" "874.9" "895.0" "855.8" "931.5" "955.4" "876.8" "961.4" "950.5" "929.7" "" "" "" "" "" "" "" "" "" "" "699.2" "631.3" "710.9" "573.4" "644.2" "716.8" "613.9" "702.1" "950.5" "756.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9197774965471602114" "False" "High" "IsMasterProtein" "O60942" "mRNA-capping enzyme OS=Homo sapiens OX=9606 GN=RNGTT PE=1 SV=1" "0.000" "False" "35.105" "14" "8" "10" "8" "597" "68.5" "8.13" "36.78" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00782, Pf01331, Pf03919" "8732" "ENSG00000111880" "RNGTT" "E1P513; E1P514; hsa:8732; O43483; O60257; O60351; O60942; Q5TCW8; Q8WUM8" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "mRNA processing; Ciliary landscape" "5" "0" "1.089" "1.029" "1.117" "1.053" "0.970" "0.962" "1.009" "1.016" "1.051" "454.2" "494.4" "467.4" "507.5" "478.1" "440.5" "437.1" "458.3" "461.4" "477.2" "" "" "" "" "" "" "" "" "" "" "364.8" "356.8" "371.3" "340.1" "330.7" "330.5" "306.0" "334.7" "461.4" "388.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-652499996560304904" "False" "High" "IsMasterProtein" "P32969" "Large ribosomal subunit protein uL6 OS=Homo sapiens OX=9606 GN=RPL9P9 PE=1 SV=1" "0.000" "False" "35.081" "36" "6" "12" "6" "192" "21.9" "9.95" "37.04" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.824" "1.102" "1.023" "1.093" "1.045" "1.260" "0.934" "0.964" "1.018" "519.2" "427.9" "572.3" "531.0" "567.5" "542.6" "654.3" "485.1" "500.3" "528.8" "" "" "" "" "" "" "" "" "" "" "417.0" "308.8" "454.6" "355.8" "392.5" "407.1" "458.1" "354.2" "500.3" "430.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173318319984318675" "False" "High" "IsMasterProtein" "Q9BXR0" "Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3" "0.000" "False" "35.054" "16" "5" "8" "5" "403" "44.0" "7.23" "28.20" "5" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01702" "81890" "ENSG00000213339" "QTRT1" "B4DFM7; hsa:81890; Q96BQ4; Q9BXQ9; Q9BXR0" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.068" "1.012" "0.989" "1.054" "0.965" "0.995" "0.956" "0.975" "1.017" "512.5" "547.5" "518.8" "507.0" "540.0" "494.7" "510.1" "490.0" "499.9" "521.4" "" "" "" "" "" "" "" "" "" "" "411.6" "395.0" "412.1" "339.7" "373.4" "371.1" "357.1" "357.9" "499.9" "424.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7165899401853608207" "False" "High" "IsMasterProtein" "P04424" "Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4" "0.000" "False" "35.054" "21" "10" "10" "10" "464" "51.6" "6.48" "29.46" "10" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf14698" "435" "ENSG00000126522" "ASL" "E7EMI0; E9PE48; hsa:435; P04424; Q6LDS5; Q96HS2" "Urea cycle" "Alanine and aspartate metabolism" "2" "0" "1.068" "1.001" "1.052" "0.986" "1.072" "1.090" "1.003" "1.038" "1.103" "559.5" "597.6" "559.9" "588.6" "551.7" "599.9" "609.6" "561.1" "580.9" "616.9" "" "" "" "" "" "" "" "" "" "" "449.4" "431.2" "444.7" "394.4" "381.5" "450.1" "426.8" "409.7" "580.9" "501.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970453667170528269" "False" "High" "IsMasterProtein" "P16083" "Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=5" "0.000" "False" "35.051" "22" "3" "4" "3" "231" "25.9" "6.29" "19.75" "3" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02525" "4835" "ENSG00000124588" "NQO2" "B2R492; P16083; Q5TD04" "Phase I - Functionalization of compounds" "Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "2" "0" "1.006" "0.993" "0.864" "0.937" "1.016" "0.908" "0.910" "0.987" "0.968" "148.8" "149.7" "147.8" "128.5" "139.4" "151.2" "135.1" "135.5" "146.9" "144.1" "" "" "" "" "" "" "" "" "" "" "119.5" "108.0" "117.4" "86.1" "96.4" "113.5" "94.6" "98.9" "146.9" "117.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256514097134295092" "False" "High" "IsMasterProtein" "Q13546" "Receptor-interacting serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=RIPK1 PE=1 SV=3" "0.000" "False" "35.017" "13" "7" "8" "7" "671" "75.9" "6.33" "25.90" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00531, Pf07714" "8737" "ENSG00000137275" "RIPK1" "A0AV89; B2RAG1; B4E3F9; hsa:8737; Q13180; Q13546; Q59H33" "IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Potential therapeutics for SARS; Ub-specific processing proteases; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TLR3-mediated TICAM1-dependent programmed cell death; Ovarian tumor domain proteases; TNFR1-induced proapoptotic signaling; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis; SARS-CoV-1-mediated effects on programmed cell death; Defective RIPK1-mediated regulated necrosis" "Apoptosis modulation and signaling; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Cytosolic DNA-sensing pathway; Host-pathogen interaction of human coronaviruses - interferon induction; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Toll-like receptor signaling pathway" "35" "0" "0.967" "0.929" "0.991" "1.015" "0.941" "0.993" "1.002" "0.993" "0.975" "839.0" "811.1" "779.8" "831.1" "851.3" "789.4" "833.0" "841.0" "833.4" "817.9" "" "" "" "" "" "" "" "" "" "" "673.9" "585.3" "619.4" "556.8" "588.8" "592.2" "583.3" "614.2" "833.4" "665.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4994086141420822230" "False" "High" "IsMasterProtein" "P02794" "Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2" "0.000" "False" "35.015" "42" "7" "12" "7" "183" "21.2" "5.55" "38.46" "7" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2495" "ENSG00000167996" "FTH1" "B3KNR5; hsa:2495; P02794; Q3KRA8; Q3SWW1" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Iron metabolism disorders" "9" "0" "1.060" "1.043" "1.088" "1.088" "1.077" "1.136" "1.106" "1.048" "1.084" "523.6" "554.8" "546.2" "569.5" "569.4" "564.1" "594.5" "579.1" "548.8" "567.7" "" "" "" "" "" "" "" "" "" "" "420.5" "400.3" "433.9" "381.5" "393.8" "423.2" "416.3" "422.9" "548.8" "461.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6527665309278316816" "False" "High" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "0.000" "False" "34.995" "31" "6" "20" "6" "178" "20.5" "8.59" "50.48" "6" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "1.032" "1.024" "1.040" "0.973" "1.027" "0.979" "0.937" "0.942" "0.990" "1310.5" "1352.1" "1342.1" "1362.4" "1275.7" "1346.0" "1282.8" "1227.5" "1234.3" "1296.8" "" "" "" "" "" "" "" "" "" "" "1052.6" "975.6" "1066.1" "912.8" "882.3" "1009.9" "898.2" "896.5" "1234.3" "1054.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "798152879982526566" "False" "High" "IsMasterProtein" "Q8WWH5" "Pseudouridylate synthase TRUB1 OS=Homo sapiens OX=9606 GN=TRUB1 PE=1 SV=1" "0.000" "False" "34.987" "29" "8" "8" "8" "349" "37.2" "8.25" "24.14" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01509" "142940" "ENSG00000165832" "TRUB1" "B2R716; hsa:142940; Q53ES2; Q8WWH5" "" "" "0" "0" "1.020" "1.010" "1.024" "0.948" "0.963" "0.940" "0.982" "0.990" "0.960" "526.2" "536.9" "531.5" "538.8" "499.0" "506.5" "494.4" "516.5" "521.0" "505.1" "" "" "" "" "" "" "" "" "" "" "422.6" "387.4" "422.2" "361.0" "345.1" "380.0" "346.1" "377.2" "521.0" "410.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787023427386069087" "False" "High" "IsMasterProtein" "P53365" "Arfaptin-2 OS=Homo sapiens OX=9606 GN=ARFIP2 PE=1 SV=1" "0.000" "False" "34.952" "22" "6" "8" "5" "341" "37.8" "6.04" "29.19" "6" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06456" "23647" "ENSG00000132254" "ARFIP2" "B4DX86; B4E306; D3DQT5; hsa:23647; P53365" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.011" "0.954" "0.953" "0.995" "1.068" "1.049" "0.969" "0.957" "1.005" "647.4" "654.3" "617.9" "616.7" "644.1" "691.4" "679.3" "627.5" "619.3" "650.9" "" "" "" "" "" "" "" "" "" "" "520.0" "472.1" "490.8" "413.2" "445.4" "518.7" "475.6" "458.3" "619.3" "529.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345660777743534482" "False" "High" "IsMasterProtein" "Q9NPJ6" "Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1" "0.000" "False" "34.936" "27" "6" "7" "6" "270" "29.7" "5.10" "28.84" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10018" "29079" "ENSG00000136146" "MED4" "B4DX67; hsa:29079; Q53GB4; Q53H68; Q5T912; Q6FHC4; Q6IA79; Q9BS95; Q9NPJ6; Q9NYR5" "PPARA activates gene expression; Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "4" "0" "0.952" "0.965" "0.955" "0.964" "1.002" "1.025" "1.010" "1.051" "0.994" "1059.0" "1007.9" "1022.2" "1011.7" "1021.3" "1061.4" "1085.0" "1069.8" "1112.8" "1052.4" "" "" "" "" "" "" "" "" "" "" "850.6" "727.2" "812.0" "677.8" "706.3" "796.3" "759.6" "781.3" "1112.8" "855.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "215729870143927910" "False" "High" "IsMasterProtein" "P52815" "Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "0.000" "False" "34.921" "23" "5" "10" "5" "198" "21.3" "8.87" "33.37" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "4" "0" "1.081" "1.018" "1.051" "1.094" "1.002" "1.100" "1.065" "1.059" "1.092" "480.4" "519.5" "488.9" "504.9" "525.6" "481.3" "528.5" "511.6" "508.9" "524.8" "" "" "" "" "" "" "" "" "" "" "385.9" "374.9" "388.4" "338.3" "363.5" "361.1" "370.0" "373.7" "508.9" "426.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4996953049836216410" "False" "High" "IsMasterProtein" "O14618" "Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1" "0.000" "False" "34.919" "30" "7" "10" "7" "274" "29.0" "5.58" "34.73" "7" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00080, Pf00403" "9973" "ENSG00000173992" "CCS" "hsa:9973; O14618; Q2M366; Q8NEV0" "Detoxification of Reactive Oxygen Species" "Amyotrophic lateral sclerosis (ALS); Copper homeostasis" "3" "0" "1.073" "1.052" "1.109" "1.112" "1.059" "1.044" "1.037" "0.995" "1.083" "412.7" "443.0" "434.3" "457.8" "459.1" "437.2" "430.7" "428.0" "410.4" "447.1" "" "" "" "" "" "" "" "" "" "" "331.5" "319.6" "345.0" "306.7" "317.5" "328.0" "301.5" "312.6" "410.4" "363.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6992356892802965689" "False" "High" "IsMasterProtein" "Q6UVJ0" "Spindle assembly abnormal protein 6 homolog OS=Homo sapiens OX=9606 GN=SASS6 PE=1 SV=1" "0.000" "False" "34.900" "12" "7" "7" "7" "657" "74.4" "7.55" "28.96" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf16531, Pf18594" "163786" "ENSG00000156876" "SASS6" "D3DT55; hsa:163786; Q6UVJ0; Q8N3K0" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "1.056" "0.984" "1.099" "1.119" "0.984" "1.255" "1.272" "1.329" "1.139" "615.6" "650.3" "605.8" "676.8" "688.9" "606.0" "772.5" "782.9" "818.3" "701.4" "" "" "" "" "" "" "" "" "" "" "494.5" "469.3" "481.2" "453.5" "476.4" "454.7" "540.9" "571.8" "818.3" "570.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1699378345202944964" "False" "High" "IsMasterProtein" "Q96MX6" "Dynein axonemal assembly factor 10 OS=Homo sapiens OX=9606 GN=DNAAF10 PE=1 SV=1" "0.000" "False" "34.888" "18" "7" "9" "7" "357" "39.7" "8.09" "24.38" "7" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf00400" "116143" "ENSG00000243667" "DNAAF10" "hsa:116143; Q96CR6; Q96MX6" "" "" "0" "0" "1.032" "1.076" "1.021" "0.987" "0.954" "0.963" "1.012" "0.982" "1.003" "998.2" "1029.9" "1074.3" "1019.6" "985.2" "952.6" "961.0" "1009.8" "980.6" "1001.4" "" "" "" "" "" "" "" "" "" "" "801.8" "743.1" "853.3" "683.2" "681.4" "714.7" "672.9" "737.5" "980.6" "814.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6383269344633082517" "False" "High" "IsMasterProtein" "Q8WTW3" "Conserved oligomeric Golgi complex subunit 1 OS=Homo sapiens OX=9606 GN=COG1 PE=1 SV=1" "0.000" "False" "34.876" "10" "9" "9" "9" "980" "108.9" "7.31" "28.49" "9" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf08700" "9382" "ENSG00000166685" "COG1" "hsa:9382; Q8WTW3; Q9NPV9; Q9P2G6" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "1.058" "1.102" "1.037" "1.019" "1.032" "0.928" "1.048" "1.010" "1.057" "608.9" "644.2" "671.2" "631.6" "620.3" "628.6" "564.9" "637.8" "615.0" "643.3" "" "" "" "" "" "" "" "" "" "" "489.0" "464.8" "533.1" "423.2" "429.0" "471.6" "395.5" "465.8" "615.0" "523.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1107540500627023376" "False" "High" "IsMasterProtein" "Q96EE3" "Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3" "0.000" "False" "34.857" "20" "6" "12" "6" "360" "39.6" "8.09" "37.94" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "81929" "ENSG00000085415" "SEH1L" "A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069" "Amino acids regulate mTORC1" "" "1" "0" "0.939" "1.005" "0.979" "1.039" "1.076" "0.913" "0.941" "1.037" "1.011" "712.6" "669.2" "715.9" "697.4" "740.2" "766.9" "650.4" "670.5" "738.8" "720.6" "" "" "" "" "" "" "" "" "" "" "572.3" "482.9" "568.7" "467.3" "511.9" "575.4" "455.4" "489.7" "738.8" "586.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965361047709710571" "False" "High" "IsMasterProtein" "Q58FG1" "Putative heat shock protein HSP 90-alpha A4 OS=Homo sapiens OX=9606 GN=HSP90AA4P PE=5 SV=1" "0.000" "False" "34.844" "15" "6" "53" "2" "418" "47.7" "5.19" "169.96" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00183, Pf13589" "" "" "HSP90AA4P" "Q58FG1" "" "" "0" "0" "1.101" "1.046" "1.099" "1.071" "1.103" "1.047" "1.063" "1.016" "1.098" "187.3" "206.2" "196.0" "205.8" "200.5" "206.6" "196.1" "199.0" "190.3" "205.7" "" "" "" "" "" "" "" "" "" "" "150.4" "148.8" "155.7" "137.9" "138.7" "155.0" "137.3" "145.3" "190.3" "167.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1707111681236337832" "False" "High" "IsMasterProtein" "Q96BY7" "Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5" "0.000" "False" "34.843" "4" "6" "7" "6" "2078" "232.6" "5.76" "24.83" "6" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624, Pf13329" "55102" "ENSG00000066739" "ATG2B" "hsa:55102; Q6ZRE7; Q96BY7; Q96DQ3; Q9NW80" "" "Alzheimer's disease and miRNA effects; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Alzheimer's disease" "3" "0" "1.028" "1.031" "1.099" "0.957" "1.050" "0.938" "1.031" "1.085" "1.057" "378.1" "388.6" "389.9" "415.5" "361.9" "397.2" "354.7" "389.8" "410.3" "399.8" "" "" "" "" "" "" "" "" "" "" "303.7" "280.4" "309.7" "278.4" "250.3" "298.0" "248.3" "284.6" "410.3" "325.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8417235359346522376" "False" "High" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "0.000" "False" "34.781" "20" "8" "11" "8" "457" "49.8" "8.41" "35.61" "8" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "RET signaling" "Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation" "4" "0" "1.141" "1.021" "1.103" "1.106" "1.057" "1.131" "1.048" "1.121" "1.066" "979.9" "1118.0" "1001.0" "1080.9" "1083.9" "1035.7" "1108.8" "1026.8" "1098.8" "1045.0" "" "" "" "" "" "" "" "" "" "" "787.1" "806.7" "795.1" "724.2" "749.7" "777.0" "776.3" "749.9" "1098.8" "849.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3035595102958398127" "False" "High" "IsMasterProtein" "P46777" "Large ribosomal subunit protein uL18 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "0.000" "False" "34.757" "27" "9" "15" "9" "297" "34.3" "9.72" "40.46" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "1.035" "1.219" "1.010" "1.075" "1.074" "1.073" "0.984" "1.195" "1.143" "816.0" "844.7" "995.0" "823.8" "877.6" "876.8" "875.7" "802.9" "975.2" "933.1" "" "" "" "" "" "" "" "" "" "" "655.4" "609.5" "790.4" "551.9" "606.9" "657.8" "613.1" "586.3" "975.2" "758.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6342285970436861386" "False" "High" "IsMasterProtein" "Q9UPM8" "AP-4 complex subunit epsilon-1 OS=Homo sapiens OX=9606 GN=AP4E1 PE=1 SV=2" "0.000" "False" "34.716" "6" "6" "7" "6" "1137" "127.2" "5.99" "26.54" "6" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf14807" "23431" "ENSG00000081014" "AP4E1" "A0AVD6; A1L4A9; A6NNX7; H0YKX4; hsa:23431; Q68D31; Q9UPM8; Q9Y588" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "" "2" "0" "1.009" "0.950" "1.025" "1.088" "0.980" "0.985" "0.982" "0.950" "1.126" "417.5" "421.2" "396.5" "428.0" "454.3" "409.0" "411.4" "410.2" "396.6" "470.1" "" "" "" "" "" "" "" "" "" "" "335.3" "304.0" "315.0" "286.8" "314.2" "306.9" "288.1" "299.6" "396.6" "382.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747633478491734615" "False" "High" "IsMasterProtein" "Q96BW5" "Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1" "0.000" "False" "34.644" "23" "8" "8" "8" "349" "39.0" "6.52" "28.54" "8" "other metabolic processes;other biological processes" "" "other molecular function" "Pf02126" "9317" "ENSG00000165983" "PTER" "B0YJ77; B3KTF5; D3DRU0; hsa:9317; Q96BW5; Q9BY46" "" "" "0" "0" "1.042" "0.997" "1.013" "0.958" "1.034" "0.923" "0.953" "0.979" "1.027" "919.9" "958.1" "917.2" "932.0" "881.1" "951.4" "849.4" "876.9" "900.8" "945.1" "" "" "" "" "" "" "" "" "" "" "738.8" "691.3" "728.6" "624.4" "609.4" "713.8" "594.7" "640.4" "900.8" "768.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6639760008816947129" "False" "High" "IsMasterProtein" "Q6ZUM4" "Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3" "0.000" "False" "34.629" "11" "8" "9" "8" "889" "98.3" "5.59" "29.66" "8" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00397, Pf00620" "201176" "ENSG00000159314; ENSG00000276836; ENSG00000276907" "ARHGAP27" "A4FU35; A8K3N5; C9JTF3; hsa:201176; Q494U0; Q6NWZ8; Q6ZUM4; Q8WY58" "CDC42 GTPase cycle; RAC1 GTPase cycle" "" "2" "0" "1.013" "0.991" "1.060" "1.044" "1.026" "0.965" "1.079" "1.032" "1.097" "843.3" "854.5" "835.7" "893.6" "880.5" "864.9" "814.1" "909.8" "870.5" "924.8" "" "" "" "" "" "" "" "" "" "" "677.3" "616.6" "663.8" "598.7" "609.0" "648.9" "570.0" "664.4" "870.5" "752.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9025151423134884799" "False" "High" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "0.000" "False" "34.585" "23" "6" "8" "6" "306" "33.9" "8.59" "30.94" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "1.087" "1.134" "1.084" "1.053" "1.100" "1.154" "1.059" "1.104" "1.064" "545.0" "592.3" "618.1" "590.6" "574.1" "599.5" "628.7" "577.1" "601.5" "580.1" "" "" "" "" "" "" "" "" "" "" "437.7" "427.4" "491.0" "395.7" "397.0" "449.8" "440.2" "421.5" "601.5" "471.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-902532758451743562" "False" "High" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "0.000" "False" "34.554" "36" "7" "9" "7" "276" "30.0" "5.30" "27.52" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "0.956" "0.965" "1.046" "1.025" "0.879" "1.015" "0.966" "0.922" "0.982" "861.2" "823.2" "830.6" "901.2" "883.0" "757.4" "874.0" "832.2" "794.1" "845.5" "" "" "" "" "" "" "" "" "" "" "691.7" "594.0" "659.8" "603.8" "610.7" "568.2" "611.9" "607.8" "794.1" "687.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4853611610042411436" "False" "High" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "0.000" "False" "34.498" "35" "8" "17" "8" "184" "20.8" "5.31" "55.51" "8" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "Pyruvate metabolism" "" "1" "0" "1.074" "1.044" "1.041" "1.001" "1.033" "1.074" "1.054" "1.021" "1.021" "2148.2" "2307.3" "2242.8" "2237.1" "2150.8" "2219.7" "2306.2" "2264.6" "2193.0" "2193.5" "" "" "" "" "" "" "" "" "" "" "1725.4" "1664.9" "1781.5" "1498.9" "1487.5" "1665.4" "1614.7" "1653.8" "2193.0" "1783.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181742408378363027" "False" "High" "IsMasterProtein" "P62253" "Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3" "0.000" "False" "34.483" "35" "6" "7" "6" "170" "19.5" "5.30" "28.80" "6" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "7326" "ENSG00000132388" "UBE2G1" "B2R7P2; D3DTK0; hsa:7326; P62253; Q99462" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "4" "0" "1.091" "1.025" "1.053" "1.050" "1.086" "1.011" "1.074" "1.150" "1.027" "521.3" "568.7" "534.4" "548.9" "547.4" "565.9" "526.8" "559.8" "599.6" "535.4" "" "" "" "" "" "" "" "" "" "" "418.7" "410.4" "424.5" "367.8" "378.6" "424.6" "368.9" "408.8" "599.6" "435.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7781995361222793159" "False" "High" "IsMasterProtein" "Q9UJX2" "Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3" "0.000" "False" "34.464" "13" "7" "9" "7" "597" "68.8" "7.02" "32.23" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04049" "8697" "ENSG00000094880" "CDC23" "A8K6E5; B4E3A2; B7WP05; D3DQB7; hsa:8697; O75433; Q53FN2; Q9BS73; Q9UJX2" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "0.997" "1.026" "0.893" "0.887" "0.967" "0.837" "0.985" "1.026" "1.032" "666.0" "664.2" "683.6" "594.5" "590.7" "644.3" "557.7" "656.1" "683.2" "687.2" "" "" "" "" "" "" "" "" "" "" "535.0" "479.3" "543.0" "398.3" "408.5" "483.4" "390.4" "479.1" "683.2" "558.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283979429673317137" "False" "High" "IsMasterProtein" "A6NIH7" "Protein unc-119 homolog B OS=Homo sapiens OX=9606 GN=UNC119B PE=1 SV=1" "0.000" "False" "34.446" "25" "5" "9" "4" "251" "28.1" "5.68" "35.88" "5" "cell organization and biogenesis;transport;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05351" "84747" "ENSG00000175970" "UNC119B" "A6NIH7; hsa:84747" "Trafficking of myristoylated proteins to the cilium" "" "1" "0" "1.070" "1.019" "1.046" "1.045" "1.050" "0.991" "1.032" "1.114" "1.050" "785.8" "840.5" "800.6" "821.8" "820.9" "825.2" "778.9" "810.8" "875.3" "825.3" "" "" "" "" "" "" "" "" "" "" "631.1" "606.5" "635.9" "550.6" "567.8" "619.2" "545.3" "592.1" "875.3" "671.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3142486401368971215" "False" "High" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "0.000" "False" "34.440" "13" "8" "10" "8" "729" "79.5" "5.22" "31.33" "8" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08477" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "0.971" "0.965" "0.956" "0.950" "0.895" "0.919" "0.956" "0.963" "1.002" "884.9" "859.2" "853.9" "845.6" "840.8" "792.3" "813.5" "845.6" "852.3" "886.7" "" "" "" "" "" "" "" "" "" "" "710.7" "620.0" "678.3" "566.6" "581.5" "594.4" "569.6" "617.6" "852.3" "721.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8044840362148842225" "False" "High" "IsMasterProtein" "O95376" "E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1" "0.000" "False" "34.432" "19" "7" "8" "7" "493" "57.8" "5.63" "22.36" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01485, Pf19422" "10425" "ENSG00000177479" "ARIH2" "hsa:10425; O95376; Q9HBZ6; Q9UEM9" "Antigen processing: Ubiquitination & Proteasome degradation" "Modulators of TCR signaling and T cell activation" "2" "0" "1.049" "1.028" "1.051" "1.071" "1.034" "1.007" "1.026" "1.005" "1.070" "570.2" "598.3" "586.2" "599.2" "610.9" "589.7" "574.2" "585.3" "573.1" "610.3" "" "" "" "" "" "" "" "" "" "" "458.0" "431.7" "465.6" "401.5" "422.5" "442.4" "402.0" "427.4" "573.1" "496.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036911108115043510" "False" "High" "IsMasterProtein" "Q96F86" "Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1" "0.000" "False" "34.431" "14" "7" "11" "7" "508" "56.0" "7.11" "33.74" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03853, Pf09532, Pf12701, Pf16598" "80153" "ENSG00000179151" "EDC3" "B3KPH0; D3DW61; hsa:80153; Q96F86; Q9H797" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.040" "1.053" "1.049" "1.139" "1.063" "1.088" "1.121" "1.135" "1.091" "623.9" "648.6" "656.7" "654.2" "710.8" "663.1" "679.0" "699.5" "708.4" "680.5" "" "" "" "" "" "" "" "" "" "" "501.1" "468.0" "521.6" "438.3" "491.6" "497.5" "475.4" "510.8" "708.4" "553.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4672476971480337418" "False" "High" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "0.000" "False" "34.427" "27" "5" "8" "5" "215" "24.9" "5.55" "29.76" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Condensation of Prometaphase Chromosomes; Neutrophil degranulation; KEAP1-NFE2L2 pathway; Regulation of PTEN stability and activity; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "21" "0" "1.113" "1.223" "1.035" "0.989" "1.093" "0.925" "1.013" "1.146" "1.075" "792.1" "881.7" "968.5" "820.0" "783.6" "865.6" "732.3" "802.2" "907.6" "851.8" "" "" "" "" "" "" "" "" "" "" "636.2" "636.2" "769.3" "549.4" "541.9" "649.4" "512.7" "585.8" "907.6" "692.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2915122001344888094" "False" "High" "IsMasterProtein" "Q13136" "Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1" "0.000" "False" "34.347" "9" "8" "8" "7" "1202" "135.7" "6.29" "26.46" "8" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00536, Pf07647" "8500" "ENSG00000131626; ENSG00000288198" "PPFIA1" "A6NLE3; hsa:8500; Q13135; Q13136; Q14567; Q8N4I2" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases" "Cell lineage map for neuronal differentiation" "7" "1" "1.035" "0.981" "0.974" "1.017" "0.932" "0.984" "1.021" "1.023" "1.018" "767.7" "794.3" "752.9" "747.6" "780.7" "715.5" "755.3" "784.2" "785.7" "781.8" "" "" "" "" "" "" "" "" "" "" "616.6" "573.2" "598.1" "500.9" "539.9" "536.8" "528.8" "572.7" "785.7" "635.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-765021547925747573" "False" "High" "IsMasterProtein" "P49366" "Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1" "0.000" "False" "34.330" "23" "7" "11" "7" "369" "40.9" "5.36" "30.22" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01916" "1725" "ENSG00000095059" "DHPS" "A8K688; hsa:1725; M0R1I5; P49366; Q13184; Q13276; Q9UDG0" "Hypusine synthesis from eIF5A-lysine" "" "1" "0" "0.958" "0.963" "0.964" "1.015" "1.034" "0.939" "0.951" "0.997" "0.989" "658.5" "631.1" "633.9" "634.8" "668.6" "681.1" "618.6" "626.3" "656.7" "651.1" "" "" "" "" "" "" "" "" "" "" "528.9" "455.4" "503.5" "425.3" "462.4" "511.0" "433.1" "457.4" "656.7" "529.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6687881647514235914" "False" "High" "IsMasterProtein" "Q147X3" "N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1" "0.000" "False" "34.293" "21" "5" "5" "5" "362" "39.3" "5.52" "19.93" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "122830" "ENSG00000139977" "NAA30" "hsa:122830; Q0IIN2; Q147X3" "Retrograde transport at the Trans-Golgi-Network" "Metapathway biotransformation Phase I and II" "2" "0" "1.003" "0.937" "1.008" "0.987" "0.910" "1.013" "1.070" "1.018" "1.028" "337.7" "338.8" "316.3" "340.3" "333.5" "307.3" "342.1" "361.4" "343.8" "347.2" "" "" "" "" "" "" "" "" "" "" "271.3" "244.5" "251.2" "228.0" "230.6" "230.5" "239.5" "263.9" "343.8" "282.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4044629129436372468" "False" "High" "IsMasterProtein" "Q14160" "Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=5" "0.000" "False" "34.258" "5" "8" "11" "8" "1630" "174.8" "5.07" "34.85" "8" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00560, Pf00595, Pf13855" "23513" "ENSG00000180900; ENSG00000274287" "SCRIB" "hsa:23513; Q14160; Q6P496; Q7Z5D1; Q8WWV8; Q96C69; Q96GG1" "CDC42 GTPase cycle; RHOQ GTPase cycle; Asymmetric localization of PCP proteins; RND2 GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle" "Thyroid stimulating hormone (TSH) signaling pathway; Complement system in neuronal development and plasticity" "8" "0" "0.992" "0.988" "1.024" "1.017" "0.922" "1.017" "1.024" "1.036" "0.960" "350.6" "347.9" "346.3" "359.1" "356.6" "323.2" "356.4" "358.9" "363.1" "336.6" "" "" "" "" "" "" "" "" "" "" "281.6" "251.0" "275.1" "240.6" "246.6" "242.5" "249.5" "262.1" "363.1" "273.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238479499176412626" "False" "High" "IsMasterProtein" "O60828" "Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1" "0.000" "False" "34.235" "17" "6" "9" "6" "265" "30.5" "6.33" "29.63" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "10084" "ENSG00000102103; ENSG00000292208" "PQBP1" "C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4" "mRNA Splicing - Major Pathway" "" "1" "0" "1.052" "1.133" "1.116" "1.072" "1.090" "1.012" "0.997" "1.050" "1.063" "588.9" "619.4" "667.1" "657.5" "631.5" "641.8" "596.2" "587.1" "618.4" "626.3" "" "" "" "" "" "" "" "" "" "" "473.0" "447.0" "529.9" "440.5" "436.8" "481.5" "417.4" "428.7" "618.4" "509.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994856410542386969" "False" "High" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "0.000" "False" "34.218" "13" "9" "10" "9" "718" "81.0" "7.30" "27.57" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.058" "1.065" "1.070" "1.020" "1.076" "1.002" "0.949" "0.998" "1.044" "536.7" "567.6" "571.4" "574.1" "547.5" "577.3" "537.9" "509.3" "535.4" "560.5" "" "" "" "" "" "" "" "" "" "" "431.1" "409.6" "453.9" "384.6" "378.7" "433.1" "376.6" "371.9" "535.4" "455.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1227550599144237947" "False" "High" "IsMasterProtein" "Q6SPF0" "Sterile alpha motif domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAMD1 PE=1 SV=1" "0.000" "False" "34.205" "12" "5" "6" "5" "538" "56.0" "7.58" "21.13" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "other molecular function" "Pf00536, Pf21524" "90378" "ENSG00000288488" "SAMD1" "hsa:90378; Q6P0R3; Q6PIS7; Q6SPF0; Q96IM4" "" "" "0" "0" "1.042" "0.942" "1.054" "1.098" "0.933" "0.968" "1.163" "1.150" "1.126" "182.5" "190.1" "171.9" "192.4" "200.4" "170.3" "176.7" "212.3" "209.9" "205.6" "" "" "" "" "" "" "" "" "" "" "146.6" "137.2" "136.5" "128.9" "138.6" "127.8" "123.7" "155.1" "209.9" "167.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657288411045177937" "False" "High" "IsMasterProtein" "O95429" "BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1" "0.000" "False" "34.185" "11" "4" "10" "3" "457" "49.6" "5.12" "33.99" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02179" "9530" "ENSG00000156735" "BAG4" "B4E217; hsa:9530; O95429; O95818" "Regulation of HSF1-mediated heat shock response; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions; TNF signaling" "Oxidative damage response" "5" "0" "0.981" "1.011" "0.964" "0.818" "0.981" "1.004" "0.994" "0.927" "0.834" "79.1" "77.6" "79.9" "76.2" "64.7" "77.6" "79.4" "78.6" "73.3" "66.0" "" "" "" "" "" "" "" "" "" "" "63.5" "56.0" "63.5" "51.1" "44.8" "58.2" "55.6" "57.4" "73.3" "53.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5358245641494386502" "False" "High" "IsMasterProtein" "Q14012" "Calcium/calmodulin-dependent protein kinase type 1 OS=Homo sapiens OX=9606 GN=CAMK1 PE=1 SV=1" "0.000" "False" "34.175" "21" "6" "8" "3" "370" "41.3" "5.29" "30.61" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00069" "8536" "ENSG00000134072" "CAMK1" "hsa:8536; Q14012; Q3KPF6" "Negative regulation of NMDA receptor-mediated neuronal transmission; Activation of RAC1 downstream of NMDARs" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Physico-chemical features and toxicity-associated pathways; Clear cell renal cell carcinoma pathways; Fragile X syndrome; CAMKK2 pathway; Calcium regulation in cardiac cells" "8" "0" "0.883" "0.989" "1.186" "0.990" "1.076" "1.169" "1.062" "1.023" "1.120" "125.6" "110.9" "124.2" "148.9" "124.3" "135.2" "146.9" "133.4" "128.5" "140.6" "" "" "" "" "" "" "" "" "" "" "100.9" "80.0" "98.6" "99.8" "86.0" "101.4" "102.8" "97.4" "128.5" "114.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "451284985450217438" "False" "High" "IsMasterProtein" "Q9NVV4" "Poly(A) RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=MTPAP PE=1 SV=1" "0.000" "False" "34.173" "12" "7" "9" "7" "582" "66.1" "9.04" "33.40" "7" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03828, Pf17797" "55149" "ENSG00000107951" "MTPAP" "D3DRX0; hsa:55149; Q659E3; Q6P7E5; Q9HA74; Q9NVV4" "" "" "0" "0" "1.032" "1.079" "1.019" "1.019" "0.980" "0.929" "1.042" "0.964" "0.935" "908.0" "937.3" "979.6" "925.2" "925.2" "890.1" "843.3" "945.8" "875.5" "849.3" "" "" "" "" "" "" "" "" "" "" "729.3" "676.3" "778.1" "619.9" "639.9" "667.9" "590.4" "690.7" "875.5" "690.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5626279923656509616" "False" "High" "IsMasterProtein" "P25325" "3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3" "0.000" "False" "34.173" "38" "11" "13" "10" "297" "33.2" "6.60" "33.35" "11" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00581" "4357" "ENSG00000128309" "MPST" "A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9" "Degradation of cysteine and homocysteine" "Trans-sulfuration pathway; Amino acid metabolism" "3" "0" "0.982" "0.967" "0.994" "1.025" "0.940" "0.974" "0.962" "0.989" "0.995" "935.5" "918.3" "904.6" "929.5" "958.6" "879.3" "911.4" "899.9" "925.1" "931.0" "" "" "" "" "" "" "" "" "" "" "751.4" "662.6" "718.6" "622.8" "663.0" "659.7" "638.1" "657.2" "925.1" "757.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1917909410339364485" "False" "High" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "0.000" "False" "34.164" "9" "10" "16" "10" "940" "99.0" "9.17" "42.79" "10" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "1.002" "1.006" "0.957" "0.932" "1.016" "0.814" "0.869" "0.921" "0.983" "1765.2" "1769.5" "1775.5" "1689.2" "1645.8" "1793.8" "1437.6" "1534.7" "1626.3" "1734.7" "" "" "" "" "" "" "" "" "" "" "1417.8" "1276.8" "1410.4" "1131.7" "1138.3" "1345.8" "1006.6" "1120.8" "1626.3" "1410.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6693318422199107583" "False" "High" "IsMasterProtein" "Q9HBI0" "Gamma-parvin OS=Homo sapiens OX=9606 GN=PARVG PE=1 SV=1" "0.000" "False" "34.148" "18" "6" "7" "6" "331" "37.5" "5.49" "23.49" "6" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00307" "64098" "ENSG00000138964" "PARVG" "B4DDW5; E7EVM6; hsa:64098; Q9BQX5; Q9HBI0; Q9NSG1" "" "Focal adhesion" "1" "0" "0.978" "0.984" "0.931" "0.931" "0.911" "0.949" "0.947" "0.897" "0.956" "602.5" "589.4" "592.7" "561.0" "560.7" "548.8" "571.6" "570.4" "540.5" "576.2" "" "" "" "" "" "" "" "" "" "" "483.9" "425.3" "470.8" "375.9" "387.8" "411.7" "400.2" "416.5" "540.5" "468.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8361684917289872737" "False" "High" "IsMasterProtein" "Q9BSW2" "EF-hand calcium-binding domain-containing protein 4B OS=Homo sapiens OX=9606 GN=CRACR2A PE=1 SV=2" "0.000" "False" "34.137" "10" "7" "10" "7" "731" "83.1" "5.24" "27.38" "7" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071, Pf13499" "84766" "ENSG00000130038" "CRACR2A" "B4E1X0; B9EK63; hsa:84766; Q9BSW2" "Neutrophil degranulation" "Vitamin D receptor pathway" "2" "0" "1.012" "1.022" "1.134" "0.936" "1.036" "1.042" "0.978" "1.022" "1.029" "592.5" "599.5" "605.3" "671.6" "554.6" "614.1" "617.1" "579.2" "605.3" "609.9" "" "" "" "" "" "" "" "" "" "" "475.9" "432.6" "480.8" "450.0" "383.6" "460.7" "432.1" "423.0" "605.3" "496.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5135100836873347765" "False" "High" "IsMasterProtein" "Q5T200" "Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1" "0.000" "False" "34.112" "5" "7" "8" "7" "1668" "196.5" "9.42" "25.30" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00642" "23091" "ENSG00000123200" "ZC3H13" "A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6" "" "" "0" "0" "1.049" "1.041" "1.180" "1.159" "1.118" "1.261" "1.209" "1.268" "1.082" "236.8" "248.5" "246.5" "279.4" "274.4" "264.8" "298.5" "286.4" "300.2" "256.2" "" "" "" "" "" "" "" "" "" "" "190.2" "179.3" "195.8" "187.2" "189.8" "198.7" "209.0" "209.2" "300.2" "208.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7478830788962877121" "False" "High" "IsMasterProtein" "Q9Y3C4" "EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1" "0.000" "False" "34.106" "40" "5" "7" "5" "175" "19.6" "6.79" "28.79" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08617" "51002" "ENSG00000144034; ENSG00000291480" "TPRKB" "D6W5H6; hsa:51002; Q8IWR6; Q8IWR7; Q9H3K4; Q9Y3C4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.021" "0.946" "0.954" "0.896" "0.863" "0.843" "0.867" "0.809" "0.900" "471.4" "481.5" "445.8" "449.6" "422.3" "407.0" "397.4" "408.9" "381.5" "424.3" "" "" "" "" "" "" "" "" "" "" "378.6" "347.4" "354.1" "301.2" "292.1" "305.4" "278.2" "298.6" "381.5" "345.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1474010075378452952" "False" "High" "IsMasterProtein" "P15924" "Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3" "0.000" "False" "34.091" "3" "9" "11" "9" "2871" "331.6" "6.81" "29.75" "9" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00681, Pf17902, Pf18373, Pf21019" "1832" "ENSG00000096696" "DSP" "B2RTT2; D7RX09; hsa:1832; O75993; P15924; Q14189; Q9UHN4" "Formation of the cornified envelope; Neutrophil degranulation; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer" "9" "0" "0.596" "0.203" "0.256" "0.319" "0.353" "0.845" "0.322" "0.439" "0.482" "938.4" "559.0" "191.0" "240.4" "299.4" "331.5" "793.1" "301.9" "412.0" "452.0" "" "" "" "" "" "" "" "" "" "" "753.7" "403.3" "151.7" "161.1" "207.1" "248.7" "555.3" "220.4" "412.0" "367.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302515266357767192" "False" "High" "IsMasterProtein" "Q9NR46" "Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1" "0.000" "False" "34.079" "22" "9" "12" "8" "395" "43.9" "5.99" "37.54" "9" "cell organization and biogenesis" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03114, Pf14604" "56904" "ENSG00000148341" "SH3GLB2" "A6NC47; A8MPS4; hsa:56904; Q8WY61; Q96JH9; Q9NR46" "" "" "0" "0" "0.946" "0.936" "1.017" "0.938" "0.929" "0.998" "1.006" "1.012" "0.966" "1006.9" "952.9" "942.6" "1024.0" "944.7" "935.9" "1005.2" "1013.3" "1019.4" "972.5" "" "" "" "" "" "" "" "" "" "" "808.8" "687.6" "748.7" "686.1" "653.4" "702.2" "703.8" "740.0" "1019.4" "790.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697340015663074004" "False" "High" "IsMasterProtein" "P56211" "cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2" "0.000" "False" "34.063" "33" "3" "13" "2" "112" "12.3" "9.09" "41.99" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "10776" "ENSG00000128989" "ARPP19" "B2R497; hsa:10776; P56211; Q6IAM2; Q86TA6; Q9UD70" "MASTL Facilitates Mitotic Progression" "" "1" "0" "1.002" "1.013" "1.066" "1.047" "1.088" "1.123" "1.125" "1.121" "1.080" "817.8" "819.6" "828.3" "872.0" "856.0" "890.1" "918.8" "920.4" "917.1" "883.4" "" "" "" "" "" "" "" "" "" "" "656.9" "591.4" "657.9" "584.2" "592.0" "667.8" "643.3" "672.2" "917.1" "718.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6380773280211833227" "False" "High" "IsMasterProtein" "Q9Y508" "E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1" "0.000" "False" "34.049" "44" "9" "14" "9" "228" "25.7" "7.25" "33.52" "9" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf05605, Pf13445, Pf18574" "55905" "ENSG00000124226" "RNF114" "B2RDQ9; B4DWY5; E1P627; hsa:55905; Q6N0B0; Q9Y508" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.026" "0.970" "0.957" "0.951" "1.000" "0.963" "1.074" "0.939" "1.025" "515.6" "528.9" "500.3" "493.5" "490.2" "515.5" "496.4" "553.7" "483.9" "528.5" "" "" "" "" "" "" "" "" "" "" "414.1" "381.6" "397.4" "330.6" "339.0" "386.8" "347.6" "404.4" "483.9" "429.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7386528410140377558" "False" "High" "IsMasterProtein" "Q9H147" "Deoxynucleotidyltransferase terminal-interacting protein 1 OS=Homo sapiens OX=9606 GN=DNTTIP1 PE=1 SV=2" "0.000" "False" "34.041" "24" "7" "7" "7" "329" "37.0" "8.97" "26.68" "7" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18192, Pf21229" "116092" "ENSG00000101457" "DNTTIP1" "B2RA18; hsa:116092; Q96DE3; Q9BQP2; Q9H147; Q9H148" "" "" "0" "0" "1.062" "1.072" "1.066" "1.105" "1.059" "0.987" "1.110" "1.059" "1.042" "582.7" "619.0" "624.5" "621.4" "644.2" "616.8" "575.4" "646.9" "617.4" "607.4" "" "" "" "" "" "" "" "" "" "" "468.0" "446.7" "496.1" "416.3" "445.5" "462.8" "402.9" "472.4" "617.4" "494.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1214418954468839603" "False" "High" "IsMasterProtein" "Q96C01" "Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1" "0.000" "False" "33.999" "41" "6" "12" "6" "138" "15.6" "7.61" "40.73" "6" "" "other cell component" "" "Pf05811" "84908" "ENSG00000035141" "FAM136A" "hsa:84908; Q96C01; Q96SS3" "" "" "0" "0" "1.068" "1.065" "0.998" "0.966" "1.100" "0.974" "0.951" "1.040" "1.014" "695.6" "742.6" "740.8" "694.0" "671.9" "765.4" "677.3" "661.8" "723.2" "705.2" "" "" "" "" "" "" "" "" "" "" "558.7" "535.8" "588.5" "464.9" "464.7" "574.3" "474.2" "483.3" "723.2" "573.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8994364974169992098" "False" "High" "IsMasterProtein" "Q6PIJ6" "F-box only protein 38 OS=Homo sapiens OX=9606 GN=FBXO38 PE=1 SV=3" "0.000" "False" "33.920" "6" "7" "7" "7" "1188" "133.9" "6.33" "20.82" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00646" "81545" "ENSG00000145868" "FBXO38" "hsa:81545; Q6PIJ6; Q6PK72; Q7Z2U0; Q86VN3; Q9BXY6; Q9H837; Q9HC40" "" "" "0" "0" "0.950" "1.033" "1.097" "1.027" "1.036" "0.990" "0.970" "1.043" "1.081" "544.4" "517.0" "562.5" "597.2" "559.1" "563.9" "538.9" "527.9" "568.0" "588.2" "" "" "" "" "" "" "" "" "" "" "437.2" "373.1" "446.8" "400.1" "386.7" "423.1" "377.3" "385.5" "568.0" "478.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6704752873658697689" "False" "High" "IsMasterProtein" "P37268" "Squalene synthase OS=Homo sapiens OX=9606 GN=FDFT1 PE=1 SV=1" "0.000" "False" "33.862" "19" "7" "10" "7" "417" "48.1" "6.54" "32.62" "7" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00494" "2222" "ENSG00000079459; ENSG00000284967" "FDFT1" "B3KQ95; B4DJE5; B4DT56; B7Z1J3; hsa:2222; P37268; Q96GT0" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism; 8p23.1 copy number variation syndrome" "12" "0" "0.952" "0.853" "0.894" "0.969" "0.983" "0.891" "1.002" "0.940" "0.931" "989.6" "942.1" "844.0" "884.3" "958.6" "972.8" "882.0" "991.6" "929.9" "920.8" "" "" "" "" "" "" "" "" "" "" "794.8" "679.8" "670.4" "592.5" "663.0" "729.9" "617.5" "724.1" "929.9" "748.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "786541619406263347" "False" "High" "IsMasterProtein" "O95243" "Methyl-CpG-binding domain protein 4 OS=Homo sapiens OX=9606 GN=MBD4 PE=1 SV=1" "0.000" "False" "33.842" "11" "6" "7" "6" "580" "66.0" "8.82" "24.67" "6" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01429" "8930" "ENSG00000129071" "MBD4" "B4DZN2; D3DNC3; D3DNC4; E9PEE4; hsa:8930; O95243; Q2MD36; Q7Z4T3; Q96F09" "Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1" "Base excision repair; DNA repair pathways, full network" "5" "0" "1.071" "1.084" "1.051" "1.069" "1.085" "1.128" "1.102" "1.203" "1.145" "402.9" "431.6" "436.8" "423.6" "430.7" "437.0" "454.3" "443.9" "484.8" "461.2" "" "" "" "" "" "" "" "" "" "" "323.6" "311.5" "347.0" "283.8" "297.9" "327.8" "318.1" "324.2" "484.8" "375.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2766829585988969351" "False" "High" "IsMasterProtein" "O75190" "DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2" "0.000" "False" "33.827" "17" "5" "10" "4" "326" "36.1" "9.16" "31.50" "5" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00226" "10049" "ENSG00000105993" "DNAJB6" "A4D232; A8K7D8; A8KAG0; B4DN73; E9PCZ2; hsa:10049; O75190; O95806; Q53EN8; Q59EF2; Q6FIC8; Q75MA2; Q9UIK6" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.959" "1.068" "0.977" "0.953" "0.946" "0.960" "0.974" "0.984" "0.997" "634.2" "607.9" "677.1" "619.4" "604.4" "600.0" "608.9" "617.7" "624.1" "632.1" "" "" "" "" "" "" "" "" "" "" "509.4" "438.7" "537.8" "415.0" "418.0" "450.2" "426.3" "451.1" "624.1" "514.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4643868144451564503" "False" "High" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "0.000" "False" "33.823" "27" "2" "12" "2" "113" "12.7" "7.44" "42.94" "2" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "2" "0" "1.008" "1.035" "1.054" "1.024" "1.040" "0.970" "1.005" "1.111" "1.086" "694.9" "700.8" "719.3" "732.2" "711.4" "723.0" "674.3" "698.3" "772.0" "754.9" "" "" "" "" "" "" "" "" "" "" "558.2" "505.7" "571.4" "490.6" "492.0" "542.5" "472.1" "510.0" "772.0" "613.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758284595644048114" "False" "High" "IsMasterProtein" "P78345" "Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2" "0.000" "False" "33.807" "23" "6" "7" "6" "283" "31.8" "9.92" "23.41" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "10557" "ENSG00000152464" "RPP38" "B3KPY0; D3DRT8; hsa:10557; P78345; Q53F71; Q8NHS8" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "Sphingolipid metabolism in senescence" "3" "0" "1.006" "1.033" "1.028" "0.991" "0.963" "0.941" "0.994" "1.018" "1.081" "622.3" "626.1" "643.1" "639.6" "616.7" "599.5" "585.5" "618.6" "633.6" "672.7" "" "" "" "" "" "" "" "" "" "" "499.8" "451.7" "510.8" "428.5" "426.5" "449.8" "409.9" "451.8" "633.6" "547.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3875322263221301035" "False" "High" "IsMasterProtein" "P51553" "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" "0.000" "False" "33.749" "25" "8" "12" "8" "393" "42.8" "8.50" "36.78" "8" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00180" "3421" "ENSG00000067829" "IDH3G" "E9PDD5; hsa:3421; P51553; Q9BUU5" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "TCA cycle (aka Krebs or citric acid cycle)" "3" "0" "1.080" "1.087" "0.990" "1.051" "1.004" "0.929" "1.010" "0.978" "1.010" "865.3" "934.1" "940.7" "856.8" "909.6" "868.5" "804.1" "873.9" "846.0" "873.8" "" "" "" "" "" "" "" "" "" "" "695.0" "674.0" "747.2" "574.0" "629.1" "651.6" "563.0" "638.2" "846.0" "710.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1655818240381757095" "False" "High" "IsMasterProtein" "Q9NSY1" "BMP-2-inducible protein kinase OS=Homo sapiens OX=9606 GN=BMP2K PE=1 SV=2" "0.000" "False" "33.741" "6" "6" "6" "6" "1161" "129.1" "6.51" "18.92" "6" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf15282" "55589" "ENSG00000138756" "BMP2K" "hsa:55589; O94791; Q4W5H2; Q8IYF2; Q8N2G7; Q8NHG9; Q9NSY1; Q9NTG8" "" "" "0" "0" "1.058" "1.013" "1.146" "1.030" "1.090" "1.097" "1.068" "1.125" "1.072" "436.0" "461.2" "441.7" "499.7" "449.2" "475.4" "478.4" "465.5" "490.3" "467.3" "" "" "" "" "" "" "" "" "" "" "350.2" "332.8" "350.9" "334.8" "310.7" "356.7" "335.0" "340.0" "490.3" "380.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327789120096563661" "False" "High" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "0.000" "False" "33.730" "21" "7" "14" "5" "388" "41.8" "8.90" "47.99" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "" "Adipogenesis" "1" "2" "0.982" "1.008" "0.996" "0.933" "0.988" "0.923" "0.943" "0.889" "0.970" "1258.7" "1236.6" "1268.2" "1253.8" "1174.3" "1243.9" "1162.0" "1187.1" "1118.9" "1220.5" "" "" "" "" "" "" "" "" "" "" "1011.0" "892.3" "1007.3" "840.0" "812.2" "933.3" "813.6" "866.9" "1118.9" "992.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4936048942270731480" "False" "High" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "0.000" "False" "33.721" "12" "6" "7" "6" "594" "66.0" "9.19" "25.01" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "1.122" "1.184" "1.071" "1.105" "1.105" "1.059" "1.172" "1.105" "1.100" "524.7" "588.8" "621.3" "562.1" "579.6" "579.9" "555.9" "615.0" "579.8" "577.2" "" "" "" "" "" "" "" "" "" "" "421.4" "424.8" "493.5" "376.6" "400.8" "435.1" "389.2" "449.1" "579.8" "469.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8196142567442196869" "False" "High" "IsMasterProtein" "P20645" "Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1" "0.000" "False" "33.693" "19" "5" "5" "5" "277" "31.0" "5.83" "21.36" "5" "transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02157" "4074" "ENSG00000003056" "M6PR" "A8K528; D3DUV5; hsa:4074; P20645" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Glycosphingolipid catabolism" "" "5" "0" "0.908" "0.829" "0.905" "1.089" "0.987" "1.151" "0.836" "1.017" "0.976" "389.1" "353.4" "322.6" "352.0" "423.6" "384.0" "447.8" "325.3" "395.5" "379.9" "" "" "" "" "" "" "" "" "" "" "312.5" "255.0" "256.3" "235.8" "293.0" "288.1" "313.5" "237.6" "395.5" "308.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1329977133710577893" "False" "High" "IsMasterProtein" "Q96EZ8" "Microspherule protein 1 OS=Homo sapiens OX=9606 GN=MCRS1 PE=1 SV=1" "0.000" "False" "33.669" "17" "6" "8" "6" "462" "51.8" "9.38" "22.88" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00498, Pf13325" "10445" "ENSG00000187778" "MCRS1" "hsa:10445; O14742; O75497; Q6VN53; Q7Z372; Q96EZ8" "Formation of WDR5-containing histone-modifying complexes; DNA Damage Recognition in GG-NER; UCH proteinases; HATs acetylate histones" "3q29 copy number variation syndrome; 8p23.1 copy number variation syndrome" "6" "0" "1.026" "1.017" "1.048" "1.057" "0.955" "0.939" "0.996" "1.023" "1.018" "644.8" "661.7" "655.5" "675.6" "681.5" "615.9" "605.3" "641.9" "659.6" "656.6" "" "" "" "" "" "" "" "" "" "" "517.9" "477.5" "520.7" "452.7" "471.3" "462.1" "423.8" "468.8" "659.6" "534.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155365173843636052" "False" "High" "IsMasterProtein" "P48507" "Glutamate--cysteine ligase regulatory subunit OS=Homo sapiens OX=9606 GN=GCLM PE=1 SV=1" "0.000" "False" "33.609" "20" "4" "5" "4" "274" "30.7" "6.02" "20.47" "4" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00248" "2730" "ENSG00000023909" "GCLM" "A8K334; D3DT45; hsa:2730; M5A959; P48507; Q6FHC1; Q9NPX9; Q9NU74" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "Glutathione metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; NRF2-ARE regulation; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "15" "0" "1.006" "0.994" "1.035" "0.996" "0.917" "0.934" "0.975" "0.960" "0.969" "720.9" "725.1" "716.6" "745.9" "718.0" "660.7" "673.3" "702.8" "691.8" "698.5" "" "" "" "" "" "" "" "" "" "" "579.0" "523.2" "569.2" "499.7" "496.6" "495.7" "471.4" "513.3" "691.8" "568.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8942814265025091180" "False" "High" "IsMasterProtein" "Q86U28" "Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2" "0.000" "False" "33.602" "41" "5" "7" "5" "154" "16.5" "5.25" "28.76" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01521" "122961" "ENSG00000165898" "ISCA2" "A6NFF1; A8K3W3; G3V291; hsa:122961; Q86U28; Q8IYZ0; Q96BB2" "Mitochondrial iron-sulfur cluster biogenesis" "" "1" "0" "1.065" "1.008" "1.098" "1.033" "0.994" "1.036" "1.020" "0.969" "1.037" "384.5" "409.6" "387.6" "422.2" "397.2" "382.1" "398.5" "392.1" "372.5" "398.8" "" "" "" "" "" "" "" "" "" "" "308.8" "295.6" "307.9" "282.9" "274.7" "286.7" "279.0" "286.3" "372.5" "324.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172177916429743793" "False" "High" "IsMasterProtein" "Q99816" "Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2" "0.000" "False" "33.552" "17" "7" "9" "7" "390" "43.9" "6.46" "30.15" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf05743, Pf09454" "7251" "ENSG00000074319" "TSG101" "hsa:7251; Q99816; Q9BUM5" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "Ebola virus infection in host; 7q11.23 copy number variation syndrome" "7" "0" "0.967" "0.962" "0.951" "0.888" "0.903" "0.792" "0.911" "0.966" "0.874" "910.2" "880.3" "875.5" "865.3" "808.4" "822.3" "720.4" "829.3" "879.2" "795.2" "" "" "" "" "" "" "" "" "" "" "731.0" "635.2" "695.4" "579.7" "559.1" "617.0" "504.4" "605.6" "879.2" "646.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7707069974883679945" "False" "High" "IsMasterProtein" "P11836" "B-lymphocyte antigen CD20 OS=Homo sapiens OX=9606 GN=MS4A1 PE=1 SV=1" "0.000" "False" "33.493" "13" "4" "7" "4" "297" "33.1" "5.05" "25.76" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04103" "931" "ENSG00000156738" "MS4A1" "A6NMS4; B4DT24; hsa:931; P08984; P11836; Q13963" "" "Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "2" "0" "0.942" "0.915" "0.983" "1.201" "1.117" "1.600" "0.947" "1.219" "1.018" "634.3" "597.6" "580.6" "623.5" "761.7" "708.8" "1014.8" "600.4" "773.0" "645.7" "" "" "" "" "" "" "" "" "" "" "509.4" "431.2" "461.2" "417.7" "526.8" "531.8" "710.5" "438.4" "773.0" "525.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697682766688933342" "False" "High" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "0.000" "False" "33.483" "37" "6" "12" "6" "169" "19.4" "8.81" "37.01" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "" "Metapathway biotransformation Phase I and II" "1" "0" "1.057" "1.033" "0.897" "0.994" "0.972" "0.994" "0.946" "0.985" "0.938" "1130.6" "1194.8" "1167.8" "1014.3" "1124.2" "1098.8" "1124.4" "1069.7" "1113.4" "1060.3" "" "" "" "" "" "" "" "" "" "" "908.1" "862.2" "927.6" "679.6" "777.5" "824.4" "787.2" "781.2" "1113.4" "862.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7418960862954659350" "False" "High" "IsMasterProtein" "Q8TD26" "Chromodomain-helicase-DNA-binding protein 6 OS=Homo sapiens OX=9606 GN=CHD6 PE=1 SV=4" "0.000" "False" "33.479" "3" "8" "10" "1" "2715" "305.2" "6.27" "27.84" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385" "84181" "ENSG00000124177" "CHD6" "hsa:84181; Q5JYQ0; Q5TGZ9; Q5TH00; Q5TH01; Q8IZR2; Q8TD26; Q8WTY0; Q9H4H6; Q9H6D4; Q9NTT7; Q9P2L1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1208867046530031718" "False" "High" "IsMasterProtein" "P47813" "Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2" "0.000" "False" "33.461" "44" "8" "20" "1" "144" "16.5" "5.24" "58.28" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf01176" "1964" "ENSG00000173674" "EIF1AX" "B2R5U5; hsa:1964; P47813; Q0VGC2; Q5JPS5; Q5JPS6" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "1.204" "1.085" "1.044" "1.052" "1.179" "1.212" "0.960" "1.176" "1.154" "385.5" "464.2" "418.3" "402.6" "405.4" "454.6" "467.1" "370.0" "453.4" "444.9" "" "" "" "" "" "" "" "" "" "" "309.7" "335.0" "332.2" "269.8" "280.4" "341.1" "327.0" "270.2" "453.4" "361.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2382558777454412534" "False" "High" "IsMasterProtein" "P25686" "DnaJ homolog subfamily B member 2 OS=Homo sapiens OX=9606 GN=DNAJB2 PE=1 SV=3" "0.000" "False" "33.389" "16" "5" "8" "4" "324" "35.6" "5.95" "29.27" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00226" "3300" "ENSG00000135924" "DNAJB2" "A8K9P6; hsa:3300; P25686; Q53QD7; Q8IUK1; Q8IUK2; Q96F52" "" "" "0" "1" "1.067" "1.050" "1.053" "1.031" "1.017" "1.030" "1.122" "1.090" "1.064" "1008.3" "1075.4" "1058.2" "1061.8" "1039.6" "1025.6" "1038.1" "1130.9" "1098.6" "1072.5" "" "" "" "" "" "" "" "" "" "" "809.8" "776.0" "840.5" "711.4" "719.0" "769.5" "726.8" "825.9" "1098.6" "872.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576893625228470779" "False" "High" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "0.000" "False" "33.374" "25" "8" "10" "8" "356" "40.0" "7.05" "30.85" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "1.005" "0.976" "1.042" "1.074" "1.040" "1.143" "1.101" "1.067" "1.076" "999.7" "1004.7" "975.7" "1041.2" "1074.0" "1039.4" "1142.2" "1101.0" "1066.9" "1075.5" "" "" "" "" "" "" "" "" "" "" "803.0" "725.0" "775.0" "697.6" "742.8" "779.9" "799.7" "804.0" "1066.9" "874.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2339365815424834793" "False" "High" "IsMasterProtein" "Q9Y217" "Myotubularin-related protein 6 OS=Homo sapiens OX=9606 GN=MTMR6 PE=1 SV=3" "0.000" "False" "33.358" "14" "7" "9" "7" "621" "71.9" "7.66" "27.34" "7" "protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06602, Pf21098" "9107" "ENSG00000139505" "MTMR6" "B2RBB5; B3KSB4; hsa:9107; Q5JRG6; Q86TB7; Q86YH4; Q96P80; Q9Y217" "Synthesis of PIPs at the plasma membrane" "8p23.1 copy number variation syndrome" "2" "0" "1.006" "1.035" "1.023" "0.992" "1.020" "0.965" "0.970" "0.998" "0.982" "559.5" "562.9" "579.0" "572.2" "555.3" "570.6" "539.8" "542.6" "558.5" "549.6" "" "" "" "" "" "" "" "" "" "" "449.4" "406.2" "459.9" "383.4" "384.0" "428.1" "378.0" "396.3" "558.5" "446.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8976168612742678464" "False" "High" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "0.000" "False" "33.354" "20" "5" "8" "4" "272" "31.2" "11.59" "30.75" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "0.950" "1.044" "1.084" "1.074" "1.190" "1.172" "1.092" "1.219" "1.123" "716.7" "681.2" "747.9" "777.2" "769.8" "852.7" "840.2" "782.4" "873.3" "805.0" "" "" "" "" "" "" "" "" "" "" "575.6" "491.5" "594.1" "520.7" "532.4" "639.8" "588.3" "571.4" "873.3" "654.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2653046833350144460" "False" "High" "IsMasterProtein" "Q96JZ2" "Hematopoietic SH2 domain-containing protein OS=Homo sapiens OX=9606 GN=HSH2D PE=1 SV=1" "0.000" "False" "33.319" "24" "7" "11" "7" "352" "39.0" "7.11" "29.10" "7" "signal transduction" "nucleus;other cell component" "" "Pf00017" "84941" "ENSG00000196684" "HSH2D" "B5ME72; hsa:84941; Q6ZNG7; Q96JZ2" "" "" "0" "0" "1.001" "0.930" "1.073" "1.021" "0.927" "0.819" "0.888" "0.948" "1.009" "526.3" "526.9" "489.6" "564.7" "537.5" "487.6" "431.1" "467.5" "498.7" "531.3" "" "" "" "" "" "" "" "" "" "" "422.7" "380.2" "388.9" "378.4" "371.7" "365.9" "301.8" "341.4" "498.7" "432.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1224682826513998034" "False" "High" "IsMasterProtein" "O00255" "Menin OS=Homo sapiens OX=9606 GN=MEN1 PE=1 SV=5" "0.000" "False" "33.277" "14" "8" "8" "8" "610" "67.5" "6.55" "27.11" "8" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05053" "4221" "ENSG00000133895" "MEN1" "A5HBC6; A5HBC7; A5HBC8; A5HBC9; A5HBD0; A5HBD1; A5HBD2; O00255; O00632; Q9BUF0; Q9BUK2" "RHO GTPases activate IQGAPs; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "10q11.21q11.23 copy number variation syndrome" "8" "0" "0.982" "0.949" "0.857" "0.984" "0.971" "0.869" "0.999" "0.979" "1.006" "578.7" "568.4" "548.9" "496.2" "569.7" "561.9" "502.9" "578.3" "566.7" "582.3" "" "" "" "" "" "" "" "" "" "" "464.8" "410.2" "436.0" "332.4" "394.0" "421.6" "352.1" "422.4" "566.7" "473.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370565265455321105" "False" "High" "IsMasterProtein" "Q8IU81" "Interferon regulatory factor 2-binding protein 1 OS=Homo sapiens OX=9606 GN=IRF2BP1 PE=1 SV=1" "0.000" "False" "33.275" "13" "7" "7" "7" "584" "61.6" "8.18" "26.25" "7" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "26145" "ENSG00000170604" "IRF2BP1" "Q53EL7; Q6DC95; Q8IU81; Q9BRZ9; Q9Y4P4" "" "" "0" "0" "1.054" "0.935" "1.024" "0.989" "0.951" "1.000" "1.046" "1.052" "1.027" "856.9" "903.4" "801.3" "877.6" "847.8" "815.3" "856.6" "896.5" "901.6" "880.0" "" "" "" "" "" "" "" "" "" "" "688.2" "651.9" "636.5" "588.0" "586.4" "611.7" "599.7" "654.7" "901.6" "715.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7534759113121094513" "False" "High" "IsMasterProtein" "Q9Y3D9" "Small ribosomal subunit protein mS23 OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "0.000" "False" "33.253" "36" "7" "9" "7" "190" "21.8" "8.90" "33.66" "7" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.031" "1.088" "1.022" "0.957" "1.013" "0.933" "1.051" "0.985" "1.020" "618.1" "637.0" "672.7" "631.5" "591.4" "626.3" "576.9" "649.3" "608.6" "630.6" "" "" "" "" "" "" "" "" "" "" "496.5" "459.6" "534.4" "423.1" "409.0" "469.9" "403.9" "474.2" "608.6" "512.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3906185605223521012" "False" "High" "IsMasterProtein" "Q9BY32" "Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2" "0.000" "False" "33.236" "37" "5" "10" "5" "194" "21.4" "5.66" "36.44" "5" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01725" "3704" "ENSG00000125877" "ITPA" "A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8" "Purine catabolism; Ribavirin ADME" "" "2" "0" "1.008" "1.016" "0.990" "1.027" "1.059" "1.100" "0.938" "0.960" "1.072" "552.7" "557.2" "561.6" "546.9" "567.5" "585.3" "608.2" "518.2" "530.4" "592.7" "" "" "" "" "" "" "" "" "" "" "443.9" "402.1" "446.1" "366.5" "392.5" "439.2" "425.8" "378.4" "530.4" "482.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4947084340596136770" "False" "High" "IsMasterProtein" "Q8TF05" "Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP4R1 PE=1 SV=1" "0.000" "False" "33.221" "11" "9" "13" "9" "950" "106.9" "4.77" "31.95" "9" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "enzyme regulator activity" "Pf02985, Pf15017" "9989" "ENSG00000154845" "PPP4R1" "hsa:9989; Q8TF05; Q99774; Q9UNQ7" "" "16p11.2 proximal deletion syndrome" "1" "0" "1.023" "0.994" "1.017" "1.018" "0.971" "1.010" "1.056" "1.056" "1.064" "1160.7" "1187.3" "1153.2" "1180.6" "1182.1" "1126.8" "1172.8" "1226.0" "1226.0" "1234.4" "" "" "" "" "" "" "" "" "" "" "932.2" "856.7" "916.0" "791.0" "817.6" "845.4" "821.1" "895.3" "1226.0" "1003.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774592991242960215" "False" "High" "IsMasterProtein" "Q9H0H0" "Integrator complex subunit 2 OS=Homo sapiens OX=9606 GN=INTS2 PE=1 SV=2" "0.000" "False" "33.188" "6" "5" "8" "5" "1204" "134.2" "6.05" "26.84" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf14750" "57508" "ENSG00000108506" "INTS2" "hsa:57508; Q9H0H0; Q9ULD3" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.198" "1.038" "1.146" "1.116" "1.055" "1.013" "1.127" "1.104" "1.053" "505.6" "605.7" "525.1" "579.6" "564.5" "533.2" "512.1" "569.8" "558.4" "532.3" "" "" "" "" "" "" "" "" "" "" "406.1" "437.1" "417.1" "388.4" "390.4" "400.1" "358.6" "416.1" "558.4" "432.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5383054079404854662" "False" "High" "IsMasterProtein" "P84022" "Mothers against decapentaplegic homolog 3 OS=Homo sapiens OX=9606 GN=SMAD3 PE=1 SV=1" "0.000" "False" "33.182" "17" "7" "12" "4" "425" "48.1" "7.15" "33.44" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4088" "ENSG00000166949" "SMAD3" "A8K4B6; B7Z4Z5; B7Z6M9; B7Z9Q2; F5H383; hsa:4088; O09064; O09144; O14510; O35273; P84022; Q92940; Q93002; Q9GKR4" "Ub-specific processing proteases; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; Interleukin-37 signaling; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; GDNF signaling; Urotensin-II-mediated signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "56" "0" "0.913" "0.948" "0.977" "0.934" "0.851" "0.879" "0.957" "0.914" "0.909" "735.3" "671.6" "697.4" "718.1" "686.5" "625.6" "646.6" "703.4" "672.1" "668.6" "" "" "" "" "" "" "" "" "" "" "590.6" "484.6" "554.0" "481.1" "474.8" "469.4" "452.7" "513.7" "672.1" "543.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765155610572928931" "False" "High" "IsMasterProtein" "Q8IZ73" "Pseudouridylate synthase RPUSD2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2" "0.000" "False" "33.177" "16" "6" "7" "6" "545" "61.3" "7.17" "19.71" "6" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00849" "27079" "ENSG00000166133" "RPUSD2" "B4DDD1; hsa:27079; Q7L989; Q8IZ73; Q92939; Q96IA7; Q96N50" "" "" "0" "0" "1.069" "0.983" "1.073" "0.993" "1.039" "0.968" "0.957" "0.944" "1.003" "506.3" "541.2" "497.6" "543.4" "502.9" "525.8" "490.0" "484.8" "477.7" "507.8" "" "" "" "" "" "" "" "" "" "" "406.7" "390.5" "395.2" "364.1" "347.8" "394.5" "343.1" "354.0" "477.7" "413.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331703410720076251" "False" "High" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "0.000" "False" "33.141" "33" "13" "18" "13" "352" "40.2" "5.47" "50.60" "13" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling" "" "2" "0" "1.039" "0.963" "0.942" "0.942" "0.953" "0.934" "1.008" "0.985" "0.945" "1293.5" "1343.4" "1246.1" "1218.8" "1218.9" "1232.5" "1207.7" "1303.9" "1274.1" "1222.4" "" "" "" "" "" "" "" "" "" "" "1038.9" "969.4" "989.8" "816.6" "843.0" "924.7" "845.6" "952.3" "1274.1" "994.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "107248944887719922" "False" "High" "IsMasterProtein" "Q6VN20" "Ran-binding protein 10 OS=Homo sapiens OX=9606 GN=RANBP10 PE=1 SV=1" "0.000" "False" "33.140" "10" "5" "8" "5" "620" "67.2" "6.77" "24.53" "5" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf00622, Pf08513, Pf10607" "57610" "ENSG00000141084" "RANBP10" "A4FTY2; B4DID0; B4DQH9; E7EW27; hsa:57610; Q6VN20; Q9P264" "MET activates RAS signaling" "Ciliary landscape" "2" "0" "0.963" "0.923" "0.965" "0.982" "0.979" "1.016" "0.924" "1.012" "1.104" "359.3" "346.0" "331.5" "346.8" "352.9" "351.9" "365.1" "331.8" "363.5" "396.8" "" "" "" "" "" "" "" "" "" "" "288.6" "249.6" "263.3" "232.3" "244.0" "264.0" "255.7" "242.3" "363.5" "322.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "515980508248597386" "False" "High" "IsMasterProtein" "Q5T1V6" "Probable ATP-dependent RNA helicase DDX59 OS=Homo sapiens OX=9606 GN=DDX59 PE=1 SV=1" "0.000" "False" "33.101" "9" "5" "6" "5" "619" "68.8" "7.44" "23.09" "5" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04438" "83479" "ENSG00000118197" "DDX59" "hsa:83479; Q5T1V6; Q6PJL2; Q8IVW3; Q9H0W3" "" "Ciliopathies" "1" "0" "1.040" "1.011" "1.144" "1.101" "1.008" "0.989" "1.075" "1.016" "1.089" "300.1" "312.2" "303.3" "343.2" "330.5" "302.6" "296.7" "322.8" "304.8" "326.8" "" "" "" "" "" "" "" "" "" "" "241.0" "225.3" "240.9" "230.0" "228.5" "227.1" "207.8" "235.7" "304.8" "265.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7159093635266280091" "False" "High" "IsMasterProtein" "O95295" "SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1" "0.000" "False" "33.068" "31" "4" "8" "4" "136" "14.9" "9.31" "31.35" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14712" "23557" "ENSG00000143553" "SNAPIN" "D3DV56; hsa:23557; O95295; Q5SXU8" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "1.061" "0.910" "1.048" "1.038" "1.033" "1.094" "1.051" "1.035" "1.023" "565.5" "600.3" "514.8" "592.5" "586.9" "583.9" "618.4" "594.3" "585.3" "578.2" "" "" "" "" "" "" "" "" "" "" "454.2" "433.1" "408.9" "397.0" "405.9" "438.1" "433.0" "434.1" "585.3" "470.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4943228809179220327" "False" "High" "IsMasterProtein" "Q8IWX8" "Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3" "0.000" "False" "33.049" "8" "7" "8" "7" "916" "103.6" "9.04" "19.94" "7" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01585, Pf01805, Pf04818" "10523" "ENSG00000085872" "CHERP" "hsa:10523; O00302; Q4G0Y5; Q8IWX8; Q8WU30; Q99492" "mRNA Splicing - Major Pathway" "" "1" "0" "0.982" "1.049" "0.957" "0.998" "0.992" "0.899" "1.054" "0.972" "0.982" "542.1" "532.5" "569.0" "518.9" "541.0" "537.8" "487.5" "571.2" "527.0" "532.2" "" "" "" "" "" "" "" "" "" "" "435.4" "384.2" "451.9" "347.6" "374.2" "403.5" "341.3" "417.2" "527.0" "432.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3793795971274937654" "False" "High" "IsMasterProtein" "Q96S59" "Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1" "0.000" "False" "33.046" "8" "5" "8" "5" "729" "77.8" "6.79" "22.06" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00622, Pf08513, Pf10607" "10048" "ENSG00000010017" "RANBP9" "A0PJA2; B2R8E1; hsa:10048; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; Q96S59" "RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape" "5" "0" "1.003" "0.993" "1.042" "1.004" "0.962" "0.997" "1.066" "1.099" "1.011" "291.4" "292.3" "289.5" "303.7" "292.7" "280.3" "290.6" "310.5" "320.2" "294.5" "" "" "" "" "" "" "" "" "" "" "234.0" "210.9" "229.9" "203.5" "202.4" "210.3" "203.5" "226.8" "320.2" "239.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1007819713485126010" "False" "High" "IsMasterProtein" "P83916" "Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1" "0.000" "False" "33.039" "24" "3" "8" "2" "185" "21.4" "4.93" "32.99" "3" "cell organization and biogenesis;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf01393" "10951" "ENSG00000108468" "CBX1" "hsa:10951; P23197; P83916" "HCMV Early Events" "Effect of progerin on genes involved in progeria" "2" "0" "0.950" "1.002" "1.108" "1.023" "1.108" "1.140" "1.052" "1.007" "1.038" "451.6" "428.8" "452.4" "500.5" "461.9" "500.4" "514.7" "475.2" "454.9" "468.6" "" "" "" "" "" "" "" "" "" "" "362.7" "309.4" "359.3" "335.3" "319.5" "375.4" "360.4" "347.0" "454.9" "381.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6259860464076082435" "False" "High" "IsMasterProtein" "Q9NR31" "Small COPII coat GTPase SAR1A OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1" "0.000" "False" "33.012" "35" "6" "9" "3" "198" "22.4" "6.68" "30.85" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00025" "56681" "ENSG00000079332" "SAR1A" "B4DQ19; hsa:56681; Q9NR31" "" "Sterol regulatory element-binding proteins (SREBP) signaling" "1" "3" "1.104" "1.002" "0.983" "0.962" "1.016" "0.756" "1.008" "0.972" "1.009" "1185.6" "1308.6" "1187.7" "1166.0" "1140.1" "1204.2" "896.3" "1194.7" "1152.6" "1195.7" "" "" "" "" "" "" "" "" "" "" "952.3" "944.2" "943.5" "781.2" "788.5" "903.5" "627.5" "872.5" "1152.6" "972.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "549572925276105069" "False" "High" "IsMasterProtein" "P11274" "Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2" "0.000" "False" "33.008" "7" "8" "9" "6" "1271" "142.7" "7.03" "32.13" "8" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00168, Pf00620, Pf00621, Pf09036, Pf19057" "613" "ENSG00000186716" "BCR" "hsa:613; P11274; P78501; Q12842; Q4LE80; Q6NZI3" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "Imatinib and chronic myeloid leukemia; Extrafollicular and follicular B cell activation by SARS-CoV-2" "11" "0" "0.967" "0.940" "1.029" "1.021" "0.988" "0.981" "0.974" "0.978" "0.998" "400.1" "387.0" "376.3" "411.8" "408.7" "395.4" "392.6" "389.9" "391.1" "399.4" "" "" "" "" "" "" "" "" "" "" "321.4" "279.2" "298.9" "275.9" "282.6" "296.6" "274.9" "284.7" "391.1" "324.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407446589588264140" "False" "High" "IsMasterProtein" "O94763" "Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3" "0.000" "False" "32.997" "10" "6" "7" "6" "535" "59.8" "5.05" "23.15" "6" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02996" "8725" "ENSG00000105176" "URI1" "A8K805; H7BY42; hsa:8725; O94763; Q8TC23; Q9UNU3" "" "" "0" "0" "0.989" "1.028" "1.022" "1.051" "0.898" "0.921" "1.025" "1.041" "0.992" "303.6" "300.4" "312.1" "310.2" "319.1" "272.6" "279.7" "311.1" "316.2" "301.1" "" "" "" "" "" "" "" "" "" "" "243.9" "216.8" "247.9" "207.8" "220.7" "204.6" "195.8" "227.2" "316.2" "244.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "961314597478386434" "False" "High" "IsMasterProtein" "P57740" "Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1" "0.000" "False" "32.997" "8" "8" "9" "8" "925" "106.3" "5.43" "31.14" "8" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04121" "57122" "ENSG00000111581" "NUP107" "B4DZ67; hsa:57122; P57740; Q6PJE1" "Separation of Sister Chromatids; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SUMOylation of ubiquitinylation proteins; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "Gastric cancer network 1; Primary ovarian insufficiency" "37" "0" "1.071" "1.059" "1.052" "1.013" "1.080" "0.969" "1.155" "1.114" "1.058" "537.5" "575.8" "569.4" "565.6" "544.6" "580.3" "520.9" "620.9" "598.7" "568.5" "" "" "" "" "" "" "" "" "" "" "431.7" "415.5" "452.3" "379.0" "376.6" "435.4" "364.7" "453.4" "598.7" "462.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819373703684901703" "False" "High" "IsMasterProtein" "Q2KHT3" "Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2" "0.000" "False" "32.977" "10" "8" "11" "8" "1053" "117.6" "5.86" "22.94" "8" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf09758, Pf19439" "23274" "ENSG00000038532" "CLEC16A" "hsa:23274; O15058; Q2KHT3; Q6ZTB2" "" "Vitamin D receptor pathway" "1" "0" "1.017" "1.008" "1.050" "1.064" "1.005" "1.057" "1.067" "1.025" "1.045" "445.1" "452.5" "448.6" "467.4" "473.6" "447.1" "470.3" "475.0" "456.1" "465.3" "" "" "" "" "" "" "" "" "" "" "357.5" "326.5" "356.3" "313.2" "327.5" "335.4" "329.3" "346.9" "456.1" "378.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318152306764108447" "False" "High" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "0.000" "False" "32.938" "12" "8" "10" "8" "726" "80.6" "8.78" "29.45" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "17" "0" "0.955" "1.009" "0.940" "0.907" "0.994" "0.996" "1.035" "0.997" "1.014" "694.8" "663.5" "700.9" "653.2" "629.9" "690.8" "691.9" "718.8" "692.9" "704.4" "" "" "" "" "" "" "" "" "" "" "558.0" "478.7" "556.7" "437.6" "435.7" "518.3" "484.4" "524.9" "692.9" "572.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826261878749587371" "False" "High" "IsMasterProtein" "P39023" "Large ribosomal subunit protein uL3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "0.000" "False" "32.896" "25" "11" "17" "11" "403" "46.1" "10.18" "39.39" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.952" "1.222" "1.086" "1.054" "1.076" "1.132" "1.034" "1.143" "1.058" "702.8" "668.8" "858.7" "763.0" "740.6" "756.2" "795.7" "726.9" "803.4" "743.5" "" "" "" "" "" "" "" "" "" "" "564.5" "482.6" "682.1" "511.2" "512.2" "567.3" "557.1" "530.9" "803.4" "604.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6073254106150692843" "False" "High" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "0.000" "False" "32.870" "7" "6" "8" "6" "1024" "114.6" "9.22" "31.01" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; Q15037; Q99575" "tRNA processing in the nucleus" "" "1" "0" "0.999" "0.946" "1.036" "1.002" "0.994" "1.030" "1.070" "1.031" "0.992" "410.2" "410.0" "388.0" "424.9" "410.8" "407.7" "422.4" "438.9" "423.1" "406.9" "" "" "" "" "" "" "" "" "" "" "329.5" "295.8" "308.2" "284.7" "284.1" "305.9" "295.8" "320.5" "423.1" "330.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272350597619465793" "False" "High" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "0.000" "False" "32.854" "23" "6" "10" "6" "305" "35.1" "5.69" "31.55" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "0.988" "1.022" "0.926" "0.828" "0.972" "0.741" "0.843" "0.812" "0.895" "1294.0" "1278.1" "1321.9" "1197.8" "1071.4" "1257.2" "959.0" "1090.3" "1051.1" "1157.6" "" "" "" "" "" "" "" "" "" "" "1039.3" "922.2" "1050.0" "802.5" "741.0" "943.2" "671.4" "796.3" "1051.1" "941.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2819385337701029723" "False" "High" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "0.000" "False" "32.790" "14" "7" "12" "7" "627" "70.7" "8.56" "32.91" "7" "other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "1.033" "1.071" "1.057" "1.093" "0.993" "1.009" "1.090" "1.105" "1.089" "230.7" "238.3" "247.1" "243.8" "252.0" "229.1" "232.7" "251.4" "254.9" "251.3" "" "" "" "" "" "" "" "" "" "" "185.3" "172.0" "196.2" "163.3" "174.3" "171.9" "162.9" "183.6" "254.9" "204.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7873771796286241695" "False" "High" "IsMasterProtein" "A6NHL2" "Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2" "0.000" "False" "32.774" "10" "5" "34" "1" "446" "49.9" "6.05" "90.97" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "79861" "ENSG00000178462" "TUBAL3" "A6NHL2; B4DKL2; hsa:79861; Q4QQJ5; Q9H6Z0" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "32" "0" "1.075" "0.990" "1.057" "1.010" "0.931" "0.820" "1.044" "0.890" "1.041" "350.9" "377.3" "347.5" "370.8" "354.5" "326.7" "287.8" "366.4" "312.2" "365.2" "" "" "" "" "" "" "" "" "" "" "281.8" "272.2" "276.0" "248.4" "245.2" "245.1" "201.5" "267.6" "312.2" "297.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4135876604710417259" "False" "High" "IsMasterProtein" "P49593" "Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3" "0.000" "False" "32.759" "18" "6" "8" "6" "454" "49.8" "5.10" "34.24" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00481" "9647" "ENSG00000100034" "PPM1F" "A8K6G3; B7Z2C3; hsa:9647; P49593; Q96PM2" "Negative regulation of NMDA receptor-mediated neuronal transmission" "" "1" "0" "1.084" "1.066" "1.298" "1.108" "1.052" "1.174" "1.058" "1.066" "1.140" "413.2" "447.8" "440.4" "536.1" "457.7" "434.8" "485.2" "437.1" "440.6" "471.2" "" "" "" "" "" "" "" "" "" "" "331.9" "323.1" "349.8" "359.2" "316.5" "326.2" "339.7" "319.2" "440.6" "383.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "385044699666679526" "False" "High" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "0.000" "False" "32.748" "9" "6" "7" "6" "843" "100.1" "6.32" "23.93" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "mRNA Splicing - Major Pathway" "" "1" "0" "0.904" "1.017" "1.055" "0.974" "1.124" "1.189" "1.119" "1.129" "1.066" "443.1" "400.5" "450.4" "467.4" "431.4" "498.0" "526.7" "495.6" "500.3" "472.4" "" "" "" "" "" "" "" "" "" "" "355.9" "289.0" "357.8" "313.1" "298.3" "373.6" "368.7" "361.9" "500.3" "384.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4600920651766906085" "False" "High" "IsMasterProtein" "O14602" "Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AY PE=1 SV=4" "0.000" "False" "32.718" "44" "8" "18" "1" "144" "16.4" "5.24" "53.95" "8" "protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01176" "9086" "ENSG00000198692" "EIF1AY" "hsa:9086; O14602; Q9BS77" "" "Translation factors" "1" "6" "0.949" "1.020" "1.021" "1.029" "0.944" "1.067" "0.998" "1.041" "1.004" "2206.4" "2094.7" "2250.4" "2252.6" "2270.7" "2083.0" "2354.4" "2202.1" "2297.3" "2214.9" "" "" "" "" "" "" "" "" "" "" "1772.2" "1511.5" "1787.6" "1509.3" "1570.5" "1562.8" "1648.5" "1608.2" "2297.3" "1801.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305631654265975414" "False" "High" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "0.000" "False" "32.716" "29" "7" "12" "7" "262" "29.3" "9.79" "35.11" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "Mitochondrial translation termination" "" "1" "0" "1.060" "0.965" "1.038" "0.990" "0.977" "1.045" "0.984" "0.987" "1.067" "786.1" "833.6" "758.4" "816.2" "778.1" "767.7" "821.3" "773.6" "776.0" "838.6" "" "" "" "" "" "" "" "" "" "" "631.4" "601.5" "602.4" "546.8" "538.1" "576.0" "575.0" "565.0" "776.0" "682.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8788472230308956" "False" "High" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "0.000" "False" "32.693" "32" "7" "12" "7" "288" "31.7" "7.66" "31.77" "7" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "Nicotinamide salvaging" "" "1" "0" "1.014" "0.968" "1.018" "1.018" "0.994" "1.006" "0.951" "0.943" "0.972" "695.3" "705.3" "673.3" "708.1" "708.1" "691.5" "699.7" "661.4" "655.8" "675.7" "" "" "" "" "" "" "" "" "" "" "558.5" "508.9" "534.8" "474.4" "489.7" "518.8" "489.9" "483.0" "655.8" "549.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3531343313582380268" "False" "High" "IsMasterProtein" "P42338" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1" "0.000" "False" "32.672" "8" "9" "10" "8" "1070" "122.7" "7.09" "34.72" "9" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5291" "ENSG00000051382" "PIK3CB" "D3DNF0; hsa:5291; P42338; Q24JU2" "Nephrin family interactions; RET signaling; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; VEGFA-VEGFR2 Pathway; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Signaling by CSF1 (M-CSF) in myeloid cells" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Focal adhesion; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "74" "0" "1.030" "1.039" "1.037" "1.040" "1.085" "1.076" "1.107" "1.055" "1.052" "931.4" "959.5" "967.3" "966.2" "968.6" "1010.3" "1002.4" "1031.4" "982.8" "979.4" "" "" "" "" "" "" "" "" "" "" "748.1" "692.3" "768.3" "647.4" "669.9" "758.0" "701.8" "753.2" "982.8" "796.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144155955974209704" "False" "High" "IsMasterProtein" "P16220" "Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=3" "0.000" "False" "32.671" "16" "4" "8" "2" "327" "35.1" "5.27" "31.27" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "1385" "ENSG00000118260" "CREB1" "hsa:1385; P16220; P21934; Q6V963; Q9UMA7" "ADORA2B mediated anti-inflammatory cytokines production; FCGR3A-mediated IL10 synthesis; HCMV Early Events; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription of neuronal ligands; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Regulation of MECP2 expression and activity; Transcriptional regulation of granulopoiesis; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK; NOTCH2 intracellular domain regulates transcription; MECP2 regulates neuronal receptors and channels; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of Adenylate Cyclase; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; PKA-mediated phosphorylation of CREB; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling; MECP2 regulates transcription factors" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Energy metabolism; miRNAs involved in DNA damage response; Folate-alcohol and cancer pathway hypotheses; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Ovarian infertility; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB signaling; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; p38 MAPK signaling pathway; NO/cGMP/PKG mediated neuroprotection; White fat cell differentiation; PI3K-Akt signaling pathway; Phosphodiesterases in neuronal function; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; G1 to S cell cycle control; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Hepatitis B infection; Melanoma; mBDNF and proBDNF regulation of GABA neurotransmission; CAMKK2 pathway; GPR143 in melanocytes and retinal pigment epithelium cells; Galanin receptor pathway; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Rubinstein-Taybi syndrome 1; Smith-Magenis and Potocki-Lupski syndrome copy number variation; Interferon type I signaling pathways; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "85" "2" "0.997" "0.956" "0.952" "0.997" "0.972" "1.005" "1.072" "0.974" "0.936" "1029.0" "1026.4" "983.7" "979.4" "1025.6" "1000.2" "1033.9" "1103.5" "1001.8" "963.6" "" "" "" "" "" "" "" "" "" "" "826.5" "740.6" "781.4" "656.2" "709.3" "750.4" "723.9" "805.9" "1001.8" "783.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4039607230823659526" "False" "High" "IsMasterProtein" "P42025" "Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1" "0.000" "False" "32.665" "20" "6" "11" "2" "376" "42.3" "6.40" "31.04" "6" "" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10120" "ENSG00000115073; ENSG00000291597" "ACTR1B" "D3DVH2; hsa:10120; P42025; Q53SK5; Q9BRB7" "Neutrophil degranulation; MHC class II antigen presentation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7649239600803351534" "False" "High" "IsMasterProtein" "Q96JY6" "PDZ and LIM domain protein 2 OS=Homo sapiens OX=9606 GN=PDLIM2 PE=1 SV=1" "0.000" "False" "32.663" "18" "5" "6" "5" "352" "37.4" "8.72" "25.35" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "64236" "ENSG00000120913" "PDLIM2" "D3DSR5; hsa:64236; J3KNH4; Q7Z584; Q86WM8; Q8WZ29; Q96JY6; Q9H4L9; Q9H7I2" "" "" "0" "0" "1.063" "1.089" "1.074" "1.058" "1.090" "1.028" "1.067" "1.107" "1.072" "1089.5" "1158.6" "1186.3" "1170.3" "1152.5" "1188.1" "1120.0" "1162.3" "1206.6" "1168.4" "" "" "" "" "" "" "" "" "" "" "875.1" "836.0" "942.3" "784.1" "797.1" "891.4" "784.2" "848.8" "1206.6" "950.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466542288326959120" "False" "High" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "0.000" "False" "32.654" "38" "6" "13" "6" "168" "19.7" "8.43" "39.52" "6" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "0.938" "0.920" "0.976" "0.969" "0.909" "0.895" "0.855" "0.919" "0.972" "413.6" "388.1" "380.7" "403.7" "400.8" "376.1" "370.0" "353.7" "380.0" "401.9" "" "" "" "" "" "" "" "" "" "" "332.2" "280.1" "302.4" "270.5" "277.2" "282.2" "259.1" "258.3" "380.0" "326.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5641944312381893453" "False" "High" "IsMasterProtein" "Q8IYB7" "DIS3-like exonuclease 2 OS=Homo sapiens OX=9606 GN=DIS3L2 PE=1 SV=4" "0.000" "False" "32.651" "12" "9" "9" "9" "885" "99.2" "6.10" "29.59" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf17216, Pf17849, Pf17877" "129563" "ENSG00000144535" "DIS3L2" "hsa:129563; Q53S79; Q580W6; Q5XKH0; Q69YG5; Q6AW99; Q7Z4T6; Q8IYB7; Q8N9K9" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "" "1" "0" "1.007" "0.974" "1.078" "0.992" "1.031" "0.965" "0.915" "0.956" "0.939" "731.2" "736.0" "711.9" "788.1" "725.2" "753.5" "705.3" "669.4" "698.7" "686.5" "" "" "" "" "" "" "" "" "" "" "587.3" "531.0" "565.5" "528.0" "501.6" "565.3" "493.8" "488.8" "698.7" "558.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749856808040687854" "False" "High" "IsMasterProtein" "Q8WTS6" "Histone-lysine N-methyltransferase SETD7 OS=Homo sapiens OX=9606 GN=SETD7 PE=1 SV=1" "0.000" "False" "32.641" "24" "7" "10" "7" "366" "40.7" "4.63" "36.61" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf02493" "80854" "ENSG00000145391" "SETD7" "B5WWL3; hsa:80854; Q0VAH3; Q4W5A9; Q8WTS6; Q9C0E6" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "0.973" "0.952" "1.019" "0.982" "0.988" "0.917" "0.979" "1.012" "1.011" "1369.1" "1331.9" "1303.4" "1395.8" "1344.6" "1352.6" "1254.9" "1339.9" "1384.9" "1384.4" "" "" "" "" "" "" "" "" "" "" "1099.7" "961.1" "1035.4" "935.2" "929.9" "1014.8" "878.6" "978.5" "1384.9" "1125.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1299453744240154091" "False" "High" "IsMasterProtein" "Q96EB1" "Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2" "0.000" "False" "32.640" "18" "8" "9" "8" "424" "46.6" "8.51" "26.53" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05625" "26610" "ENSG00000109911" "ELP4" "B4E3W0; E7EPZ6; hsa:26610; Q96EB1; Q9H4E8; Q9NX11" "HATs acetylate histones" "Mesodermal commitment pathway" "2" "0" "1.055" "1.017" "0.978" "1.038" "1.075" "1.004" "1.069" "1.018" "1.062" "557.7" "588.4" "567.4" "545.3" "578.7" "599.4" "559.7" "596.2" "567.4" "592.3" "" "" "" "" "" "" "" "" "" "" "447.9" "424.6" "450.7" "365.4" "400.2" "449.7" "391.8" "435.4" "567.4" "481.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8678565654600364554" "False" "High" "IsMasterProtein" "Q8WWV3" "Reticulon-4-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=RTN4IP1 PE=1 SV=2" "0.000" "False" "32.617" "16" "7" "8" "7" "396" "43.6" "9.11" "27.71" "7" "developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf08240, Pf13602" "84816" "ENSG00000130347" "RTN4IP1" "hsa:84816; Q8N9B3; Q8WWV3; Q8WZ66; Q9BRA4" "" "" "0" "0" "1.031" "1.069" "1.068" "1.235" "1.095" "1.091" "1.226" "1.103" "1.063" "439.9" "453.3" "470.0" "469.6" "543.3" "481.8" "479.8" "539.4" "485.2" "467.5" "" "" "" "" "" "" "" "" "" "" "353.3" "327.1" "373.4" "314.6" "375.7" "361.5" "335.9" "393.9" "485.2" "380.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2950951748836187489" "False" "High" "IsMasterProtein" "Q96MG7" "Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1" "0.000" "False" "32.612" "24" "6" "7" "6" "304" "34.3" "9.28" "25.47" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01454" "56160" "ENSG00000185115; ENSG00000282130" "NSMCE3" "hsa:56160; Q8IW16; Q8TEI6; Q96MG7; Q9H214" "SUMOylation of DNA damage response and repair proteins" "15q11q13 copy number variation" "2" "0" "1.112" "1.039" "1.107" "1.107" "1.064" "1.094" "0.998" "1.001" "1.009" "293.6" "326.6" "305.2" "325.0" "325.0" "312.5" "321.3" "292.9" "294.0" "296.2" "" "" "" "" "" "" "" "" "" "" "235.8" "235.6" "242.4" "217.7" "224.8" "234.5" "225.0" "213.9" "294.0" "240.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8446655200423982377" "False" "High" "IsMasterProtein" "Q8N4C8" "Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN=MINK1 PE=1 SV=2" "0.000" "False" "32.584" "7" "9" "10" "5" "1332" "149.7" "7.85" "25.79" "9" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "50488" "ENSG00000141503" "MINK1" "D3DTK3; D3DTK4; hsa:50488; Q5U8Z0; Q8N4C8; Q9P1X1; Q9P2R8" "Oxidative Stress Induced Senescence" "Angiopoietin-like protein 8 regulatory pathway; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "5" "0" "1.131" "1.122" "1.062" "1.201" "1.123" "1.223" "1.193" "1.198" "1.105" "165.9" "187.6" "186.1" "176.2" "199.3" "186.3" "203.0" "197.9" "198.7" "183.3" "" "" "" "" "" "" "" "" "" "" "133.3" "135.4" "147.8" "118.1" "137.8" "139.8" "142.1" "144.5" "198.7" "149.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1394219767961209764" "False" "High" "IsMasterProtein" "Q5T5Y3" "Calmodulin-regulated spectrin-associated protein 1 OS=Homo sapiens OX=9606 GN=CAMSAP1 PE=1 SV=2" "0.000" "False" "32.584" "5" "8" "9" "8" "1602" "177.9" "6.73" "27.42" "8" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08683, Pf11971, Pf17095" "157922" "ENSG00000130559" "CAMSAP1" "A1L4L2; B2REB2; B2REB3; hsa:157922; Q5T5Y3; Q70W33; Q8NCY0; Q96E80; Q96FM3; Q9UFJ5" "" "" "0" "0" "0.987" "0.935" "1.031" "0.976" "0.959" "0.965" "0.960" "1.029" "0.980" "335.1" "330.6" "313.3" "345.4" "326.9" "321.4" "323.5" "321.7" "345.0" "328.4" "" "" "" "" "" "" "" "" "" "" "269.1" "238.6" "248.9" "231.4" "226.1" "241.1" "226.5" "234.9" "345.0" "267.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2834511568131292996" "False" "High" "IsMasterProtein" "O00329" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2" "0.000" "False" "32.583" "8" "9" "10" "8" "1044" "119.4" "7.18" "32.81" "9" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5293" "ENSG00000171608" "PIK3CD" "A6NCG0; G1FFP1; hsa:5293; O00329; O15445; Q5SR49" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; IL-3 signaling pathway; Focal adhesion; Overview of nanoparticle effects; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "56" "0" "1.109" "1.028" "1.075" "1.164" "1.091" "1.051" "0.990" "0.956" "1.142" "303.9" "337.1" "312.5" "326.8" "353.7" "331.5" "319.4" "301.0" "290.4" "347.1" "" "" "" "" "" "" "" "" "" "" "244.1" "243.2" "248.3" "219.0" "244.6" "248.7" "223.7" "219.8" "290.4" "282.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128551820349889228" "False" "High" "IsMasterProtein" "P51531" "Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2" "0.000" "False" "32.562" "5" "8" "13" "1" "1590" "181.2" "7.20" "34.48" "8" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6595" "ENSG00000080503" "SMARCA2" "B1ALG3; B1ALG4; D3DRH4; D3DRH5; hsa:6595; P51531" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "Retinoblastoma gene in cancer; Pathways affected in adenoid cystic carcinoma; VEGFA-VEGFR2 signaling; Rett syndrome; Thermogenesis; Kleefstra syndrome" "8" "0" "1.036" "1.024" "1.221" "1.081" "1.006" "1.033" "1.096" "0.974" "1.099" "34.9" "36.1" "35.7" "42.6" "37.7" "35.1" "36.0" "38.2" "34.0" "38.3" "" "" "" "" "" "" "" "" "" "" "28.0" "26.1" "28.4" "28.5" "26.1" "26.3" "25.2" "27.9" "34.0" "31.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575991461264525713" "False" "High" "IsMasterProtein" "Q99933" "BAG family molecular chaperone regulator 1 OS=Homo sapiens OX=9606 GN=BAG1 PE=1 SV=4" "0.000" "False" "32.558" "24" "6" "7" "6" "345" "38.8" "7.81" "19.99" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf02179" "573" "ENSG00000107262" "BAG1" "hsa:573; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q99933; Q9Y2V4" "Regulation of HSF1-mediated heat shock response" "Androgen receptor signaling pathway" "2" "0" "1.050" "0.927" "1.017" "0.965" "1.066" "1.043" "0.881" "1.013" "0.976" "434.8" "456.5" "402.9" "442.3" "419.7" "463.6" "453.6" "382.9" "440.3" "424.5" "" "" "" "" "" "" "" "" "" "" "349.3" "329.4" "320.0" "296.3" "290.3" "347.8" "317.6" "279.7" "440.3" "345.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2014587900474496052" "False" "High" "IsMasterProtein" "Q9P015" "Large ribosomal subunit protein uL15m OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" "0.000" "False" "32.548" "19" "6" "9" "6" "296" "33.4" "10.01" "33.63" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00828" "29088" "ENSG00000137547" "MRPL15" "hsa:29088; Q96Q54; Q9H0Y1; Q9P015" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.972" "0.974" "1.013" "0.957" "0.917" "0.939" "0.989" "0.942" "0.999" "684.8" "665.6" "667.0" "693.8" "655.7" "628.3" "642.9" "677.5" "645.0" "684.4" "" "" "" "" "" "" "" "" "" "" "550.0" "480.3" "529.8" "464.9" "453.5" "471.4" "450.1" "494.8" "645.0" "556.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3764850706603646464" "False" "High" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "0.000" "False" "32.546" "35" "5" "10" "5" "181" "20.5" "8.82" "38.78" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "0" "0.963" "0.951" "0.936" "0.986" "0.997" "0.921" "0.888" "0.931" "0.940" "931.0" "896.9" "885.3" "871.1" "917.7" "928.2" "857.0" "827.1" "867.0" "875.1" "" "" "" "" "" "" "" "" "" "" "747.7" "647.2" "703.2" "583.6" "634.7" "696.4" "600.0" "604.1" "867.0" "711.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8461791288305677895" "False" "High" "IsMasterProtein" "Q92783" "Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3" "0.000" "False" "32.537" "13" "6" "9" "5" "540" "59.1" "4.82" "27.56" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "8027" "ENSG00000136738" "STAM" "B0YJ99; D3DRU5; hsa:8027; Q8N6D9; Q92783" "Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Metalloprotease DUBs; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "Vitamin D receptor pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "11" "0" "1.014" "1.005" "0.959" "1.078" "1.042" "1.047" "1.013" "1.098" "1.015" "564.1" "572.3" "567.1" "540.8" "608.4" "588.0" "590.8" "571.6" "619.2" "572.5" "" "" "" "" "" "" "" "" "" "" "453.1" "412.9" "450.4" "362.4" "420.7" "441.2" "413.7" "417.5" "619.2" "465.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-381937601164646059" "False" "High" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "0.000" "False" "32.514" "25" "9" "13" "9" "358" "40.6" "5.94" "35.16" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "7" "0" "0.959" "0.987" "0.976" "1.033" "0.936" "0.968" "0.958" "0.967" "0.944" "987.3" "947.0" "974.2" "963.5" "1019.6" "923.7" "955.4" "945.5" "954.6" "932.3" "" "" "" "" "" "" "" "" "" "" "793.0" "683.3" "773.8" "645.5" "705.2" "693.0" "668.9" "690.5" "954.6" "758.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835883825689200365" "False" "High" "IsMasterProtein" "Q92979" "Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4" "0.000" "False" "32.512" "30" "6" "10" "6" "244" "26.7" "9.17" "30.96" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03587" "10436" "ENSG00000126749" "EMG1" "hsa:10436; O00675; O00726; Q92979" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.954" "1.091" "0.971" "1.041" "1.097" "0.918" "0.976" "0.968" "1.022" "572.5" "546.0" "624.3" "555.7" "595.8" "628.3" "525.3" "558.8" "554.4" "584.9" "" "" "" "" "" "" "" "" "" "" "459.8" "394.0" "495.9" "372.3" "412.0" "471.4" "367.8" "408.1" "554.4" "475.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7918100123629271451" "False" "High" "IsMasterProtein" "Q9NWV4" "CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1" "0.000" "False" "32.500" "42" "6" "7" "6" "160" "18.0" "5.01" "25.45" "6" "" "" "other molecular function" "Pf05907" "54987" "ENSG00000162384" "CZIB" "hsa:54987; Q9NWV4" "" "" "0" "0" "0.925" "0.888" "0.892" "0.966" "0.996" "1.043" "0.957" "0.900" "0.968" "1273.0" "1177.6" "1129.9" "1135.1" "1229.8" "1268.4" "1327.5" "1218.8" "1145.8" "1232.2" "" "" "" "" "" "" "" "" "" "" "1022.5" "849.7" "897.5" "760.5" "850.5" "951.7" "929.4" "890.1" "1145.8" "1002.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6534484608378348231" "False" "High" "IsMasterProtein" "Q9H000" "E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens OX=9606 GN=MKRN2 PE=1 SV=2" "0.000" "False" "32.498" "21" "7" "7" "7" "416" "46.9" "7.61" "24.06" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00097, Pf00642, Pf14608" "23609" "ENSG00000075975" "MKRN2" "A6NIA2; B3KRC5; B4DPR4; Q8N391; Q96BD4; Q9BUY2; Q9H000; Q9NRY1" "" "" "0" "0" "1.015" "1.049" "1.051" "1.112" "1.024" "1.087" "1.163" "1.157" "1.081" "499.3" "506.8" "523.7" "524.6" "555.0" "511.2" "542.6" "580.5" "577.6" "540.0" "" "" "" "" "" "" "" "" "" "" "401.0" "365.7" "416.0" "351.5" "383.8" "383.6" "379.9" "423.9" "577.6" "439.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265990204774033592" "False" "High" "IsMasterProtein" "O75175" "CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1" "0.000" "False" "32.491" "10" "7" "10" "7" "753" "81.8" "6.20" "33.67" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04065, Pf04153" "4849" "ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615" "CNOT3" "hsa:4849; O75175; Q9NZN7; Q9UF76" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "0.933" "0.833" "0.958" "0.933" "0.910" "0.971" "0.871" "0.973" "0.955" "355.5" "331.8" "296.2" "340.6" "331.8" "323.7" "345.2" "309.6" "345.8" "339.5" "" "" "" "" "" "" "" "" "" "" "285.6" "239.4" "235.3" "228.2" "229.5" "242.8" "241.7" "226.1" "345.8" "276.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6165163621982420395" "False" "High" "IsMasterProtein" "P42694" "Probable helicase with zinc finger domain OS=Homo sapiens OX=9606 GN=HELZ PE=1 SV=2" "0.000" "False" "32.473" "5" "9" "9" "9" "1942" "218.8" "7.42" "25.01" "9" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00642, Pf13086, Pf13087" "9931" "ENSG00000198265" "HELZ" "hsa:9931; I6L9H4; P42694" "" "" "0" "0" "1.068" "1.039" "1.100" "1.077" "0.999" "1.060" "1.019" "0.992" "1.060" "645.4" "689.4" "670.3" "709.7" "695.4" "644.8" "684.2" "657.7" "640.0" "684.2" "" "" "" "" "" "" "" "" "" "" "518.4" "497.5" "532.4" "475.5" "480.9" "483.8" "479.0" "480.3" "640.0" "556.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6265096555801149049" "False" "High" "IsMasterProtein" "P06132" "Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2" "0.000" "False" "32.449" "16" "5" "9" "5" "367" "40.8" "6.14" "35.16" "5" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01208" "7389" "ENSG00000126088" "UROD" "A8K762; hsa:7389; P06132; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "1.103" "1.017" "1.092" "1.087" "1.116" "1.106" "0.960" "1.006" "1.029" "740.2" "816.4" "753.0" "808.1" "804.5" "825.9" "818.4" "710.9" "744.9" "761.3" "" "" "" "" "" "" "" "" "" "" "594.5" "589.1" "598.1" "541.4" "556.4" "619.7" "573.0" "519.2" "744.9" "619.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3163608174618773486" "False" "High" "IsMasterProtein" "Q5SXM2" "snRNA-activating protein complex subunit 4 OS=Homo sapiens OX=9606 GN=SNAPC4 PE=1 SV=1" "0.000" "False" "32.440" "7" "8" "9" "7" "1469" "159.3" "8.28" "28.64" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13921" "6621" "ENSG00000165684" "SNAPC4" "hsa:6621; Q5SXM2; Q9Y6P7" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "" "3" "0" "1.119" "0.886" "1.253" "1.054" "0.860" "1.095" "0.980" "0.894" "0.949" "473.2" "529.4" "419.2" "593.0" "498.6" "407.1" "518.3" "463.9" "423.3" "449.0" "" "" "" "" "" "" "" "" "" "" "380.1" "382.0" "333.0" "397.3" "344.9" "305.5" "362.9" "338.8" "423.3" "365.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370481134034691073" "False" "High" "IsMasterProtein" "P22307" "Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2" "0.000" "False" "32.420" "12" "6" "8" "6" "547" "59.0" "6.89" "27.77" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00108, Pf02036, Pf02803" "6342" "ENSG00000116171" "SCP2" "A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1; hsa:6342; P22307; Q15432; Q16622; Q5VVZ1; Q6NXF4; Q99430" "TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Mitochondrial fatty acid oxidation disorders; DNA damage response (only ATM dependent)" "10" "0" "1.112" "1.071" "1.114" "1.048" "1.128" "1.137" "1.197" "1.156" "1.076" "1302.4" "1447.9" "1394.8" "1450.4" "1365.5" "1469.7" "1480.7" "1558.4" "1504.9" "1400.8" "" "" "" "" "" "" "" "" "" "" "1046.1" "1044.8" "1108.0" "971.7" "944.4" "1102.7" "1036.7" "1138.1" "1504.9" "1139.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331601319371966852" "False" "High" "IsMasterProtein" "P21964" "Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2" "0.000" "False" "32.402" "25" "5" "6" "5" "271" "30.0" "5.47" "23.59" "5" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01596" "1312" "ENSG00000093010" "COMT" "A8MPV9; hsa:1312; P21964; Q6IB07; Q6ICE6; Q9BWC7" "Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase" "Dopamine metabolism; Flavan-3-ol metabolic pathway; MTHFR deficiency; 22q11.2 copy number variation syndrome; Primary ovarian insufficiency; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways" "13" "0" "1.028" "0.888" "1.028" "0.938" "0.927" "0.957" "0.865" "0.929" "0.971" "513.7" "528.0" "456.3" "528.1" "481.9" "476.3" "491.7" "444.5" "477.0" "498.8" "" "" "" "" "" "" "" "" "" "" "412.6" "381.0" "362.5" "353.8" "333.3" "357.3" "344.3" "324.6" "477.0" "405.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8124726233717471609" "False" "High" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "0.000" "False" "32.374" "20" "7" "10" "5" "372" "42.8" "8.79" "30.41" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "Estrogen-dependent gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Interactions of Tat with host cellular proteins" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "20" "0" "1.075" "1.109" "1.125" "1.078" "0.979" "0.947" "1.115" "1.013" "1.094" "282.0" "303.3" "312.6" "317.2" "303.8" "276.0" "267.1" "314.4" "285.7" "308.5" "" "" "" "" "" "" "" "" "" "" "226.5" "218.8" "248.3" "212.6" "210.1" "207.1" "187.0" "229.6" "285.7" "250.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2508229497243424265" "False" "High" "IsMasterProtein" "P82673" "Small ribosomal subunit protein mS35 OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" "0.000" "False" "32.355" "23" "6" "9" "6" "323" "36.8" "8.24" "29.70" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10213" "60488" "ENSG00000061794" "MRPS35" "hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.953" "0.982" "0.891" "0.934" "0.897" "0.841" "1.028" "0.968" "0.858" "616.2" "587.3" "604.9" "549.3" "575.3" "553.0" "518.1" "633.8" "596.2" "528.7" "" "" "" "" "" "" "" "" "" "" "494.9" "423.8" "480.5" "368.0" "397.9" "414.9" "362.8" "462.8" "596.2" "430.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221367924290970171" "False" "High" "IsMasterProtein" "Q07812" "Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1" "0.000" "False" "32.344" "36" "5" "11" "5" "192" "21.2" "5.22" "28.59" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "581" "ENSG00000087088" "BAX" "A8K4W1; hsa:581; P55269; Q07812; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6" "Release of apoptotic factors from the mitochondria; Pyroptosis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation, translocation and oligomerization of BAX; NTRK3 as a dependence receptor" "miRNA regulation of DNA damage response; TP53 network; Leptin signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; p53 transcriptional gene network; Pleural mesothelioma; Complement system in neuronal development and plasticity; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; IL-26 signaling pathways; HDAC6 interactions in the central nervous system; DNA damage response; DNA damage response (only ATM dependent)" "48" "0" "1.131" "1.052" "1.106" "1.094" "0.989" "1.015" "1.066" "1.151" "1.095" "999.4" "1130.0" "1051.3" "1105.8" "1093.8" "988.9" "1014.7" "1065.4" "1150.2" "1094.0" "" "" "" "" "" "" "" "" "" "" "802.7" "815.4" "835.1" "740.9" "756.5" "742.0" "710.4" "778.1" "1150.2" "889.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3945672141617060885" "False" "High" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "0.000" "False" "32.325" "17" "7" "7" "7" "1410" "152.4" "8.60" "23.44" "7" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Signaling by ALK fusions and activated point mutants" "Ectoderm differentiation" "2" "0" "1.019" "0.907" "0.963" "0.933" "0.976" "1.006" "1.004" "1.030" "0.962" "558.3" "569.0" "506.2" "537.4" "521.0" "545.0" "561.6" "560.4" "575.0" "537.1" "" "" "" "" "" "" "" "" "" "" "448.4" "410.6" "402.1" "360.1" "360.4" "408.9" "393.2" "409.3" "575.0" "436.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "105236357953779316" "False" "High" "IsMasterProtein" "Q9H0R4" "Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1" "0.000" "False" "32.305" "26" "5" "6" "5" "259" "28.5" "6.24" "22.84" "5" "other metabolic processes" "" "other molecular function" "Pf13242, Pf13344" "84064" "ENSG00000167220" "HDHD2" "A8K7T3; hsa:84064; Q96NV4; Q9H0R4" "" "" "0" "0" "0.923" "0.936" "0.912" "0.878" "0.913" "0.972" "0.859" "0.850" "0.896" "1143.2" "1054.7" "1069.6" "1042.6" "1003.6" "1043.6" "1111.4" "982.2" "971.2" "1024.0" "" "" "" "" "" "" "" "" "" "" "918.2" "761.0" "849.6" "698.6" "694.1" "783.0" "778.1" "717.3" "971.2" "832.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-630716066930521994" "False" "High" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "0.000" "False" "32.301" "32" "4" "8" "4" "195" "22.0" "5.44" "30.39" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "30" "0" "1.009" "1.000" "1.068" "1.032" "0.965" "1.013" "0.937" "1.024" "1.011" "263.2" "265.5" "263.4" "281.3" "271.6" "253.9" "266.6" "246.6" "269.6" "266.1" "" "" "" "" "" "" "" "" "" "" "211.4" "191.6" "209.2" "188.4" "187.8" "190.5" "186.6" "180.1" "269.6" "216.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258533483115152097" "False" "High" "IsMasterProtein" "Q53H96" "Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3" "0.000" "False" "32.293" "39" "8" "14" "8" "274" "28.6" "7.72" "40.22" "8" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03807, Pf14748" "65263" "ENSG00000104524; ENSG00000276657" "PYCR3" "B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896" "Glutamate and glutamine metabolism" "" "1" "0" "0.990" "1.025" "1.065" "0.991" "1.072" "0.976" "0.949" "1.012" "1.035" "781.1" "773.2" "800.5" "832.1" "774.1" "837.2" "762.2" "741.6" "790.2" "808.5" "" "" "" "" "" "" "" "" "" "" "627.3" "557.9" "635.9" "557.5" "535.4" "628.2" "533.7" "541.6" "790.2" "657.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3647234260862617095" "False" "High" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "0.000" "False" "32.261" "22" "5" "6" "5" "209" "23.4" "8.24" "22.78" "5" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "0.849" "0.773" "0.962" "1.035" "0.857" "0.890" "0.912" "0.863" "0.930" "131.8" "111.9" "101.9" "126.8" "136.3" "112.9" "117.3" "120.2" "113.7" "122.6" "" "" "" "" "" "" "" "" "" "" "105.8" "80.8" "81.0" "84.9" "94.3" "84.7" "82.1" "87.8" "113.7" "99.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2332565569261485395" "False" "High" "IsMasterProtein" "Q9BZL6" "Serine/threonine-protein kinase D2 OS=Homo sapiens OX=9606 GN=PRKD2 PE=1 SV=3" "0.000" "False" "32.259" "8" "5" "5" "4" "878" "96.7" "6.84" "21.03" "5" "cell adhesion;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00169" "25865" "ENSG00000105287" "PRKD2" "B4DTS2; hsa:25865; M0QZW1; M0R2R2; Q8NCK8; Q8TB08; Q9BZL6; Q9P0T6; Q9Y3X8" "Sphingolipid de novo biosynthesis" "VEGFA-VEGFR2 signaling; Gastrin signaling pathway" "3" "1" "1.064" "0.987" "1.153" "1.132" "1.039" "1.112" "1.138" "1.060" "1.091" "352.4" "375.1" "347.9" "406.2" "398.9" "366.3" "391.9" "400.9" "373.7" "384.5" "" "" "" "" "" "" "" "" "" "" "283.1" "270.6" "276.4" "272.2" "275.9" "274.8" "274.4" "292.8" "373.7" "312.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9112301912693417232" "False" "High" "IsMasterProtein" "Q13332" "Receptor-type tyrosine-protein phosphatase S OS=Homo sapiens OX=9606 GN=PTPRS PE=1 SV=3" "0.000" "False" "32.246" "5" "7" "8" "7" "1948" "216.9" "6.46" "26.03" "7" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00041, Pf00102, Pf07679, Pf13927" "5802" "ENSG00000105426" "PTPRS" "hsa:5802; O75255; O75870; Q13332; Q15718; Q16341; Q2M3R7" "ECM proteoglycans; Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases; Signaling by NTRK3 (TRKC)" "" "4" "0" "1.007" "1.002" "1.107" "1.049" "1.025" "1.207" "1.037" "1.104" "1.134" "310.9" "313.1" "311.4" "344.3" "326.1" "318.6" "375.3" "322.5" "343.1" "352.5" "" "" "" "" "" "" "" "" "" "" "249.7" "225.9" "247.4" "230.7" "225.5" "239.0" "262.8" "235.6" "343.1" "286.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6367954742648610470" "False" "High" "IsMasterProtein" "Cont_E1BJK2" "Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB1 PE=3 SV=1" "0.000" "True" "32.245" "10" "5" "63" "1" "450" "50.0" "5.11" "133.53" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "541271" "ENSBIXG00000020524; ENSBTAG00000018785" "TUBB1" "A0A4W2CSS1; bta:541271; E1BJK2" "" "Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4005780129157962021" "False" "High" "IsMasterProtein" "Q9BUR4" "Telomerase Cajal body protein 1 OS=Homo sapiens OX=9606 GN=WRAP53 PE=1 SV=1" "0.000" "False" "32.211" "13" "4" "5" "4" "548" "59.3" "4.58" "21.38" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "55135" "ENSG00000141499" "WRAP53" "B3KPR9; D3DTQ4; hsa:55135; Q08ET9; Q9BUR4; Q9NW09" "Association of TriC/CCT with target proteins during biosynthesis; Telomere Extension By Telomerase" "" "2" "0" "0.973" "0.927" "1.041" "1.003" "0.876" "1.000" "0.941" "0.939" "0.990" "176.6" "171.8" "163.6" "183.7" "177.1" "154.7" "176.5" "166.2" "165.8" "174.7" "" "" "" "" "" "" "" "" "" "" "141.8" "124.0" "130.0" "123.1" "122.5" "116.1" "123.6" "121.3" "165.8" "142.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1721155162359169472" "False" "High" "IsMasterProtein" "Q9UBQ0" "Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1" "0.000" "False" "32.193" "40" "7" "12" "7" "182" "20.5" "6.79" "41.26" "7" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12850" "51699" "ENSG00000111237" "VPS29" "hsa:51699; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7; Q9UBQ0" "WNT ligand biogenesis and trafficking" "" "1" "0" "0.917" "0.941" "0.871" "0.920" "0.935" "0.914" "0.892" "0.932" "0.929" "1073.2" "983.8" "1009.7" "934.8" "987.1" "1003.3" "980.8" "956.9" "1000.4" "996.5" "" "" "" "" "" "" "" "" "" "" "862.0" "709.9" "802.0" "626.3" "682.7" "752.8" "686.7" "698.8" "1000.4" "810.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5042642415102067907" "False" "High" "IsMasterProtein" "Q99549" "M-phase phosphoprotein 8 OS=Homo sapiens OX=9606 GN=MPHOSPH8 PE=1 SV=2" "0.000" "False" "32.191" "9" "6" "7" "6" "860" "97.1" "6.06" "27.00" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00385, Pf12796" "54737" "ENSG00000196199" "MPHOSPH8" "B7Z6F9; hsa:54737; Q5JPE5; Q5JTQ0; Q86TK3; Q96MK4; Q99549; Q9BTP1" "" "" "0" "0" "1.002" "1.125" "1.195" "1.080" "1.044" "1.171" "1.100" "1.092" "1.173" "209.6" "210.1" "235.7" "250.4" "226.3" "218.8" "245.4" "230.4" "228.9" "245.9" "" "" "" "" "" "" "" "" "" "" "168.3" "151.6" "187.3" "167.8" "156.5" "164.2" "171.8" "168.3" "228.9" "200.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144806605175812753" "False" "High" "IsMasterProtein" "Q7L9B9" "Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EEPD1 PE=1 SV=2" "0.000" "False" "32.171" "13" "7" "10" "7" "569" "62.4" "8.41" "32.01" "7" "DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes" "nucleic acid binding activity" "Pf03372, Pf12836" "80820" "ENSG00000122547" "EEPD1" "hsa:80820; Q7L9B9; Q96K64; Q9C0F7" "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "" "1" "0" "1.000" "0.890" "1.020" "1.032" "1.094" "1.268" "1.056" "1.103" "1.110" "322.4" "322.5" "286.8" "328.9" "332.7" "352.8" "409.0" "340.4" "355.7" "357.9" "" "" "" "" "" "" "" "" "" "" "259.0" "232.7" "227.8" "220.4" "230.1" "264.7" "286.3" "248.6" "355.7" "291.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1550632578398820844" "False" "High" "IsMasterProtein" "Q8N3P4" "Vacuolar protein sorting-associated protein 8 homolog OS=Homo sapiens OX=9606 GN=VPS8 PE=1 SV=3" "0.000" "False" "32.165" "5" "7" "8" "7" "1428" "161.7" "5.64" "23.49" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf12816" "23355" "ENSG00000156931" "VPS8" "A8K8Q8; B9EIQ1; C9JB61; hsa:23355; O94896; Q63HP2; Q8N3P4; Q9BVP9; Q9H9B0" "" "" "0" "0" "1.020" "0.998" "1.161" "0.953" "0.910" "1.082" "0.963" "0.939" "1.094" "270.8" "276.2" "270.2" "314.4" "258.0" "246.5" "293.0" "260.7" "254.3" "296.2" "" "" "" "" "" "" "" "" "" "" "217.5" "199.3" "214.6" "210.7" "178.5" "184.9" "205.1" "190.4" "254.3" "240.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6332903783671194577" "False" "High" "IsMasterProtein" "P62070" "Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1" "0.000" "False" "32.163" "27" "5" "8" "5" "204" "23.4" "6.01" "28.67" "5" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00071" "22800" "ENSG00000133818" "RRAS2" "B2R9Z3; B7Z5Z2; B7Z6C4; B7Z7H6; hsa:22800; P17082; P62070" "RND1 GTPase cycle" "MAPK signaling pathway; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGFR tyrosine kinase inhibitor resistance; Regulation of actin cytoskeleton" "6" "0" "0.934" "0.882" "1.019" "1.024" "0.951" "0.995" "0.930" "0.963" "0.951" "556.7" "520.0" "491.2" "567.3" "569.9" "529.6" "554.0" "517.7" "536.2" "529.2" "" "" "" "" "" "" "" "" "" "" "447.2" "375.2" "390.2" "380.1" "394.2" "397.3" "387.9" "378.1" "536.2" "430.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4939449039103849626" "False" "High" "IsMasterProtein" "Q96G74" "OTU domain-containing protein 5 OS=Homo sapiens OX=9606 GN=OTUD5 PE=1 SV=1" "0.000" "False" "32.122" "11" "4" "4" "4" "571" "60.6" "6.54" "15.70" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf02338" "55593" "ENSG00000068308; ENSG00000292211" "OTUD5" "B4DGG7; G5E9D7; hsa:55593; Q4KMN9; Q8N6T5; Q96G74; Q9H650; Q9H9U0; Q9NT65" "Ovarian tumor domain proteases; Negative regulators of DDX58/IFIH1 signaling" "Gastric cancer network 2; Novel intracellular components of RIG-I-like receptor pathway" "4" "0" "1.087" "1.038" "1.035" "1.004" "1.038" "1.063" "1.138" "1.112" "1.128" "278.3" "302.5" "288.9" "288.0" "279.5" "288.9" "295.8" "316.8" "309.4" "314.0" "" "" "" "" "" "" "" "" "" "" "223.5" "218.3" "229.5" "193.0" "193.3" "216.7" "207.1" "231.4" "309.4" "255.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3561433586626158640" "False" "High" "IsMasterProtein" "Q7Z5L2" "Coiled-coil domain-containing protein R3HCC1L OS=Homo sapiens OX=9606 GN=R3HCC1L PE=1 SV=3" "0.000" "False" "32.064" "10" "6" "7" "6" "792" "87.8" "5.16" "26.54" "6" "" "" "" "" "27291" "ENSG00000166024" "R3HCC1L" "hsa:27291; O60598; Q5W0B4; Q5W0B5; Q7Z5L2; Q86VT9; Q8N9H0" "" "" "0" "0" "0.990" "0.888" "1.077" "0.984" "1.012" "1.074" "0.981" "0.952" "1.041" "185.0" "183.1" "164.3" "199.4" "182.1" "187.3" "198.7" "181.5" "176.1" "192.7" "" "" "" "" "" "" "" "" "" "" "148.6" "132.1" "130.5" "133.6" "125.9" "140.5" "139.1" "132.5" "176.1" "156.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1344142120960836563" "False" "High" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "0.000" "False" "32.041" "19" "8" "12" "8" "393" "44.9" "8.63" "32.33" "8" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "Platelet degranulation" "" "1" "0" "1.022" "1.006" "1.026" "1.116" "1.097" "1.120" "1.046" "1.185" "1.044" "438.5" "447.9" "440.9" "449.8" "489.3" "481.1" "491.3" "458.7" "519.6" "457.6" "" "" "" "" "" "" "" "" "" "" "352.2" "323.2" "350.2" "301.3" "338.4" "361.0" "344.0" "335.0" "519.6" "372.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "76993751311903605" "False" "High" "IsMasterProtein" "Q9GZZ9" "Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1" "0.000" "False" "32.040" "24" "7" "10" "7" "404" "44.8" "4.84" "34.01" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00899" "79876" "ENSG00000081307" "UBA5" "A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.849" "0.833" "0.867" "0.910" "0.953" "0.932" "1.045" "0.937" "0.953" "268.4" "228.0" "223.5" "232.7" "244.2" "255.8" "250.3" "280.5" "251.6" "255.9" "" "" "" "" "" "" "" "" "" "" "215.6" "164.5" "177.5" "155.9" "168.9" "191.9" "175.2" "204.8" "251.6" "208.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2146106311129589736" "False" "High" "IsMasterProtein" "P35244" "Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1" "0.000" "False" "32.023" "45" "4" "11" "4" "121" "13.6" "5.08" "38.78" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08661" "6119" "ENSG00000106399" "RPA3" "hsa:6119; P35244; Q549U6" "HSF1 activation; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "36" "0" "1.006" "1.018" "0.927" "0.988" "1.009" "0.971" "0.997" "0.942" "0.987" "1350.4" "1358.5" "1375.4" "1252.5" "1334.1" "1362.1" "1311.9" "1346.3" "1271.7" "1332.4" "" "" "" "" "" "" "" "" "" "" "1084.6" "980.3" "1092.5" "839.2" "922.7" "1022.0" "918.5" "983.2" "1271.7" "1083.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5530400762788936201" "False" "High" "IsMasterProtein" "O43299" "AP-5 complex subunit zeta-1 OS=Homo sapiens OX=9606 GN=AP5Z1 PE=1 SV=2" "0.000" "False" "32.014" "8" "5" "6" "5" "807" "88.5" "7.01" "26.25" "5" "DNA metabolism;stress response;transport" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14764" "9907" "ENSG00000242802" "AP5Z1" "hsa:9907; O43299; Q8N3X2; Q96H80" "" "" "0" "0" "1.001" "1.019" "1.034" "0.990" "1.079" "0.942" "0.945" "1.063" "1.056" "289.9" "290.3" "295.4" "299.7" "287.0" "312.6" "273.0" "274.1" "308.1" "306.2" "" "" "" "" "" "" "" "" "" "" "232.8" "209.5" "234.7" "200.8" "198.5" "234.6" "191.1" "200.1" "308.1" "249.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6251688870276858346" "False" "High" "IsMasterProtein" "Q9BX40" "Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1" "0.000" "False" "32.012" "21" "6" "7" "6" "385" "42.0" "9.69" "20.83" "6" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "149986" "ENSG00000149657" "LSM14B" "hsa:149986; Q6PFW8; Q96LH8; Q9BX40" "" "" "0" "0" "1.130" "1.073" "1.042" "1.028" "1.003" "1.093" "1.095" "1.030" "1.127" "335.2" "378.9" "359.7" "349.3" "344.6" "336.4" "366.3" "367.0" "345.3" "378.0" "" "" "" "" "" "" "" "" "" "" "269.3" "273.4" "285.7" "234.0" "238.3" "252.4" "256.5" "268.0" "345.3" "307.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7438164124212550785" "False" "High" "IsMasterProtein" "Q96EV8" "Dysbindin OS=Homo sapiens OX=9606 GN=DTNBP1 PE=1 SV=1" "0.000" "False" "31.981" "19" "6" "11" "6" "351" "39.5" "4.67" "35.38" "6" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04440" "84062" "ENSG00000047579" "DTNBP1" "A8K3V3; hsa:84062; Q5THY3; Q5THY4; Q96EV8; Q96NV2; Q9H0U2; Q9H3J5" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "0.975" "0.951" "0.960" "0.971" "0.970" "0.898" "0.920" "0.968" "0.968" "504.2" "491.5" "479.6" "484.1" "489.4" "489.1" "452.9" "463.7" "488.2" "488.0" "" "" "" "" "" "" "" "" "" "" "405.0" "354.6" "381.0" "324.3" "338.5" "366.9" "317.1" "338.7" "488.2" "396.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760294074974619673" "False" "High" "IsMasterProtein" "O95319" "CUGBP Elav-like family member 2 OS=Homo sapiens OX=9606 GN=CELF2 PE=1 SV=1" "0.000" "False" "31.963" "13" "6" "11" "4" "508" "54.3" "8.76" "33.57" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10659" "ENSG00000048740" "CELF2" "B7ZAN9; O95319; Q7KYU4; Q8N499; Q92950; Q96NW9; Q96RQ5; Q96RQ6; Q9UL67" "" "mRNA processing; Opioid receptor pathways" "2" "0" "1.089" "0.948" "1.110" "1.120" "1.073" "0.968" "0.963" "1.034" "1.137" "285.4" "310.9" "270.6" "316.9" "319.8" "306.1" "276.3" "274.9" "295.1" "324.5" "" "" "" "" "" "" "" "" "" "" "229.2" "224.3" "214.9" "212.3" "221.2" "229.7" "193.4" "200.8" "295.1" "263.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6790579379401263319" "False" "High" "IsMasterProtein" "Q8IU85" "Calcium/calmodulin-dependent protein kinase type 1D OS=Homo sapiens OX=9606 GN=CAMK1D PE=1 SV=1" "0.000" "False" "31.944" "26" "7" "9" "4" "385" "42.9" "7.21" "30.89" "7" "other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "57118" "ENSG00000183049" "CAMK1D" "B0YIY0; hsa:57118; Q8IU85; Q9HD31" "" "" "0" "2" "0.992" "0.907" "0.911" "0.996" "0.948" "0.961" "0.997" "0.980" "0.989" "576.2" "571.8" "522.8" "525.2" "573.7" "546.2" "553.8" "574.4" "565.0" "570.0" "" "" "" "" "" "" "" "" "" "" "462.8" "412.6" "415.3" "351.9" "396.7" "409.8" "387.7" "419.5" "565.0" "463.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551300482488071361" "False" "High" "IsMasterProtein" "P78332" "RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5" "0.000" "False" "31.944" "8" "11" "12" "9" "1123" "128.6" "6.32" "29.44" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf17780" "10180" "ENSG00000004534" "RBM6" "B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3" "" "" "0" "0" "0.953" "0.968" "1.079" "1.030" "1.120" "1.086" "0.991" "1.065" "1.048" "646.1" "615.6" "625.5" "697.3" "665.8" "723.7" "701.8" "640.4" "688.3" "677.1" "" "" "" "" "" "" "" "" "" "" "519.0" "444.2" "496.8" "467.2" "460.4" "543.0" "491.4" "467.7" "688.3" "550.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6132827760965537069" "False" "High" "IsMasterProtein" "Q7Z3D6" "D-glutamate cyclase, mitochondrial OS=Homo sapiens OX=9606 GN=DGLUCY PE=1 SV=2" "0.000" "False" "31.906" "14" "7" "8" "7" "616" "66.4" "6.79" "25.64" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf07286, Pf14336" "80017" "ENSG00000133943" "DGLUCY" "B3KUI7; hsa:80017; Q7Z3D6; Q86SW3; Q86SX8; Q86SX9; Q86T08; Q86TV5; Q96GW5; Q9H7G0; Q9H8Y9; Q9H9W6" "" "" "0" "0" "0.965" "0.994" "0.997" "0.985" "0.896" "0.890" "0.908" "0.974" "0.979" "423.0" "408.3" "420.3" "421.5" "416.8" "378.9" "376.4" "384.1" "412.1" "414.2" "" "" "" "" "" "" "" "" "" "" "339.8" "294.6" "333.9" "282.4" "288.2" "284.3" "263.6" "280.5" "412.1" "336.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5384337703464320291" "False" "High" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "0.000" "False" "31.901" "14" "8" "12" "8" "640" "70.7" "7.62" "34.25" "8" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Gluconeogenesis" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "7" "0" "0.905" "0.945" "0.963" "0.963" "0.919" "0.870" "0.878" "0.955" "0.971" "483.7" "438.0" "456.9" "466.0" "466.1" "444.6" "420.8" "424.7" "462.0" "469.9" "" "" "" "" "" "" "" "" "" "" "388.5" "316.0" "362.9" "312.2" "322.3" "333.6" "294.6" "310.1" "462.0" "382.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7289415820017297402" "False" "High" "IsMasterProtein" "P82675" "Small ribosomal subunit protein uS5m OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2" "0.000" "False" "31.882" "14" "6" "7" "6" "430" "48.0" "9.92" "25.39" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00333, Pf03719, Pf21251" "64969" "ENSG00000144029" "MRPS5" "hsa:64969; P82675; Q4ZFY5; Q96LJ6; Q9BWI4; Q9BYC4" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.989" "0.980" "0.947" "0.904" "0.918" "0.856" "1.025" "1.009" "0.974" "637.7" "630.9" "624.9" "603.6" "576.5" "585.7" "545.8" "653.5" "643.1" "621.4" "" "" "" "" "" "" "" "" "" "" "512.2" "455.2" "496.4" "404.4" "398.7" "439.4" "382.1" "477.3" "643.1" "505.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049271637643204736" "False" "High" "IsMasterProtein" "Q96F63" "Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1" "0.000" "False" "31.829" "16" "3" "4" "3" "343" "38.9" "4.59" "17.25" "3" "" "nucleus" "" "Pf09747" "90324" "ENSG00000142039" "CCDC97" "hsa:90324; Q658N6; Q96F63; Q96IF3" "" "" "0" "0" "1.044" "1.022" "1.055" "1.148" "0.985" "1.072" "1.083" "1.039" "1.061" "323.3" "337.6" "330.6" "341.2" "371.2" "318.6" "346.7" "350.2" "335.9" "343.2" "" "" "" "" "" "" "" "" "" "" "259.7" "243.6" "262.6" "228.6" "256.7" "239.1" "242.8" "255.7" "335.9" "279.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684474116770674977" "False" "High" "IsMasterProtein" "Q9NW68" "BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1" "0.000" "False" "31.764" "16" "6" "7" "6" "430" "47.1" "4.49" "19.38" "6" "" "other cell component" "" "Pf03909" "55108" "ENSG00000160058" "BSDC1" "B4DMS7; B4DTI7; B4DTP7; B4E2X8; hsa:55108; Q49AT8; Q68DY6; Q6IAA3; Q6MZK1; Q6UXS1; Q9HAL9; Q9NW68" "" "" "0" "0" "1.088" "1.020" "1.142" "1.039" "0.972" "1.010" "1.171" "1.073" "1.007" "262.8" "285.9" "268.1" "300.2" "273.0" "255.5" "265.5" "307.8" "281.9" "264.7" "" "" "" "" "" "" "" "" "" "" "211.1" "206.3" "213.0" "201.1" "188.8" "191.7" "185.9" "224.8" "281.9" "215.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8682459872602538883" "False" "High" "IsMasterProtein" "Q8N108" "Mesoderm induction early response protein 1 OS=Homo sapiens OX=9606 GN=MIER1 PE=1 SV=2" "0.000" "False" "31.747" "16" "7" "8" "7" "512" "57.9" "4.42" "21.93" "7" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "57708" "ENSG00000198160" "MIER1" "C9JFD4; hsa:57708; Q08AE0; Q32NC4; Q5T104; Q5TAD1; Q5TAD2; Q5TAD4; Q5TAD5; Q6AHY8; Q86TB4; Q8N108; Q8N156; Q8N161; Q8NC37; Q8NES4; Q8NES5; Q8NES6; Q8WWG2; Q9HCG2" "" "" "0" "0" "1.112" "1.001" "1.099" "1.126" "0.977" "1.032" "1.022" "0.979" "0.935" "252.0" "280.3" "252.3" "276.9" "283.7" "246.1" "260.1" "257.5" "246.7" "235.7" "" "" "" "" "" "" "" "" "" "" "202.4" "202.2" "200.4" "185.6" "196.2" "184.7" "182.1" "188.1" "246.7" "191.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6077742637667714135" "False" "High" "IsMasterProtein" "Q00535" "Cyclin-dependent kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3" "0.000" "False" "31.741" "29" "8" "13" "7" "292" "33.3" "7.66" "37.63" "8" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1020" "ENSG00000164885" "CDK5" "A1XKG3; hsa:1020; Q00535" "DARPP-32 events; NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Activated NTRK2 signals through CDK5" "miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "16" "0" "1.087" "1.022" "1.036" "1.039" "0.969" "0.985" "1.029" "0.984" "1.045" "526.3" "572.3" "537.8" "545.1" "547.0" "510.1" "518.5" "541.5" "517.9" "550.0" "" "" "" "" "" "" "" "" "" "" "422.7" "413.0" "427.2" "365.2" "378.3" "382.7" "363.0" "395.4" "517.9" "447.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4065169870199249389" "False" "High" "IsMasterProtein" "Q86VP1" "Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2" "0.000" "False" "31.739" "11" "10" "10" "10" "789" "90.8" "5.43" "32.58" "10" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07888, Pf17751, Pf18112" "8887" "ENSG00000106052" "TAX1BP1" "A4D196; B4DKU7; E7ENV2; hsa:8887; O60398; O95770; Q13311; Q86VP1; Q9BQG5; Q9UI88" "Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "" "2" "0" "0.940" "0.948" "0.853" "0.868" "0.936" "0.896" "0.861" "0.908" "0.896" "989.6" "930.5" "938.6" "844.0" "858.8" "925.9" "887.0" "852.2" "898.5" "886.3" "" "" "" "" "" "" "" "" "" "" "794.8" "671.4" "745.6" "565.5" "593.9" "694.7" "621.0" "622.4" "898.5" "720.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981502460717336485" "False" "High" "IsMasterProtein" "O60244" "Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2" "0.000" "False" "31.672" "6" "9" "9" "9" "1454" "160.5" "8.73" "25.25" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08638" "9282" "ENSG00000180182" "MED14" "hsa:9282; O60244; Q4KMR7; Q9UNB3" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "Vitamin D in inflammatory diseases" "5" "0" "1.135" "1.098" "1.124" "1.063" "0.999" "1.007" "0.963" "0.985" "1.040" "480.5" "545.2" "527.6" "540.2" "511.0" "479.9" "484.0" "462.6" "473.1" "499.7" "" "" "" "" "" "" "" "" "" "" "386.0" "393.4" "419.1" "362.0" "353.4" "360.0" "338.9" "337.8" "473.1" "406.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2132288438487461579" "False" "High" "IsMasterProtein" "Q9BV68" "E3 ubiquitin-protein ligase RNF126 OS=Homo sapiens OX=9606 GN=RNF126 PE=1 SV=2" "0.000" "False" "31.593" "19" "4" "5" "4" "311" "33.8" "5.47" "22.31" "4" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13639, Pf14369" "55658" "ENSG00000070423" "RNF126" "hsa:55658; Q9BV68; Q9NWX1" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.083" "0.998" "1.091" "1.115" "1.018" "1.070" "1.051" "0.952" "1.174" "185.6" "201.0" "185.2" "202.4" "206.8" "188.9" "198.5" "195.1" "176.6" "217.8" "" "" "" "" "" "" "" "" "" "" "149.0" "145.0" "147.1" "135.6" "143.1" "141.7" "139.0" "142.4" "176.6" "177.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5612646896286873908" "False" "High" "IsMasterProtein" "Q6PJG2" "Mitotic deacetylase-associated SANT domain protein OS=Homo sapiens OX=9606 GN=MIDEAS PE=1 SV=2" "0.000" "False" "31.585" "10" "9" "11" "9" "1045" "114.9" "9.19" "26.64" "9" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01448" "91748" "ENSG00000156030" "MIDEAS" "hsa:91748; Q6PJG2; Q6PK13; Q6PK59; Q6ZS23" "" "" "0" "0" "1.091" "1.108" "1.068" "1.048" "1.118" "1.032" "1.147" "1.055" "1.057" "887.5" "967.8" "983.7" "948.1" "930.1" "992.1" "916.2" "1017.7" "936.1" "937.8" "" "" "" "" "" "" "" "" "" "" "712.8" "698.4" "781.4" "635.2" "643.3" "744.4" "641.5" "743.2" "936.1" "762.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289518910119416826" "False" "High" "IsMasterProtein" "P61966" "AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1" "0.000" "False" "31.576" "31" "5" "10" "4" "158" "18.7" "5.73" "31.40" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1174" "ENSG00000106367" "AP1S1" "B2R5D8; hsa:1174; P61966; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9" "Lysosome Vesicle Biogenesis; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "1" "0.993" "1.006" "0.948" "0.951" "0.999" "0.938" "0.967" "0.955" "0.955" "1457.3" "1446.6" "1465.8" "1381.5" "1385.7" "1455.6" "1367.1" "1409.2" "1391.8" "1391.2" "" "" "" "" "" "" "" "" "" "" "1170.5" "1043.8" "1164.3" "925.6" "958.4" "1092.1" "957.2" "1029.2" "1391.8" "1131.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9137773696009286865" "False" "High" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "0.000" "False" "31.573" "29" "3" "13" "3" "118" "12.9" "5.52" "38.18" "3" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "1.086" "1.066" "1.093" "0.973" "1.051" "1.072" "0.979" "1.033" "1.024" "1264.1" "1373.1" "1347.2" "1382.2" "1229.5" "1328.3" "1355.6" "1237.3" "1306.1" "1294.5" "" "" "" "" "" "" "" "" "" "" "1015.3" "990.8" "1070.1" "926.1" "850.3" "996.6" "949.1" "903.6" "1306.1" "1052.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023390433505774979" "False" "High" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "0.000" "False" "31.569" "24" "6" "14" "6" "346" "36.2" "8.79" "40.50" "6" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Citric acid cycle (TCA cycle)" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "3" "0" "0.983" "1.011" "0.960" "0.994" "1.014" "0.941" "0.988" "1.028" "1.031" "1459.6" "1434.5" "1476.2" "1401.6" "1451.3" "1480.0" "1374.0" "1442.2" "1499.8" "1505.5" "" "" "" "" "" "" "" "" "" "" "1172.3" "1035.1" "1172.6" "939.1" "1003.7" "1110.4" "962.0" "1053.3" "1499.8" "1224.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4995074517937679177" "False" "High" "IsMasterProtein" "O95628" "CCR4-NOT transcription complex subunit 4 OS=Homo sapiens OX=9606 GN=CNOT4 PE=1 SV=3" "0.000" "False" "31.566" "13" "7" "10" "7" "575" "63.5" "7.03" "31.51" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf14570" "4850" "ENSG00000080802" "CNOT4" "B7Z6I4; E7ET38; F8VQP3; O95339; O95627; O95628; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "1.040" "1.058" "1.039" "1.029" "1.065" "1.004" "1.070" "1.042" "1.045" "845.2" "878.6" "894.5" "878.5" "869.6" "900.5" "848.9" "904.3" "880.9" "883.6" "" "" "" "" "" "" "" "" "" "" "678.8" "634.0" "710.6" "588.6" "601.4" "675.6" "594.4" "660.4" "880.9" "718.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5954226143684266914" "False" "High" "IsMasterProtein" "P10398" "Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2" "0.000" "False" "31.544" "13" "8" "9" "5" "606" "67.5" "9.01" "30.41" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "369" "ENSG00000078061" "ARAF" "hsa:369; P07557; P10398; Q5H9B2; Q5H9B3" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway" "33" "3" "1.061" "1.135" "1.046" "1.041" "1.074" "1.065" "1.160" "1.129" "1.101" "859.2" "911.9" "975.3" "898.8" "894.1" "922.7" "914.8" "996.8" "970.5" "945.9" "" "" "" "" "" "" "" "" "" "" "690.1" "658.0" "774.7" "602.2" "618.4" "692.3" "640.5" "727.9" "970.5" "769.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2555536461123867922" "False" "High" "IsMasterProtein" "Q86U90" "Threonylcarbamoyl-AMP synthase OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1" "0.000" "False" "31.525" "34" "8" "11" "8" "279" "29.3" "8.57" "30.09" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01300" "79693" "ENSG00000196449" "YRDC" "hsa:79693; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q86U90; Q9H5F8" "" "" "0" "0" "1.171" "0.962" "1.104" "1.119" "1.065" "1.045" "1.074" "1.001" "1.006" "899.6" "1053.3" "865.0" "992.8" "1006.9" "957.7" "940.5" "966.0" "900.8" "905.4" "" "" "" "" "" "" "" "" "" "" "722.6" "760.0" "687.1" "665.2" "696.4" "718.6" "658.5" "705.5" "900.8" "736.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1957491016862499710" "False" "High" "IsMasterProtein" "P13073" "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" "0.000" "False" "31.514" "39" "7" "12" "7" "169" "19.6" "9.51" "34.58" "7" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion;nucleus" "transporter activity" "Pf02936" "1327" "ENSG00000131143" "COX4I1" "B2R4J2; D3DUM7; hsa:1327; P13073; Q6P666" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "8" "0" "1.085" "1.130" "1.033" "1.128" "1.195" "1.020" "1.124" "1.135" "1.087" "719.6" "780.4" "813.4" "743.3" "811.4" "860.0" "734.3" "808.7" "816.7" "782.0" "" "" "" "" "" "" "" "" "" "" "578.0" "563.1" "646.1" "498.0" "561.2" "645.2" "514.1" "590.6" "816.7" "636.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828949100496623215" "False" "High" "IsMasterProtein" "Q92844" "TRAF family member-associated NF-kappa-B activator OS=Homo sapiens OX=9606 GN=TANK PE=1 SV=2" "0.000" "False" "31.501" "16" "6" "8" "6" "425" "47.8" "5.68" "25.92" "6" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf12845" "10010" "ENSG00000136560" "TANK" "D3DPB5; hsa:10010; Q7Z4J6; Q92844; Q92885" "Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF6 mediated IRF7 activation" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Novel intracellular components of RIG-I-like receptor pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "7" "0" "1.007" "0.967" "0.958" "1.071" "1.064" "0.809" "1.004" "0.942" "0.918" "182.3" "183.6" "176.2" "174.6" "195.3" "194.0" "147.5" "183.0" "171.7" "167.3" "" "" "" "" "" "" "" "" "" "" "146.4" "132.5" "140.0" "117.0" "135.1" "145.6" "103.3" "133.6" "171.7" "136.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4424001123554839232" "False" "High" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "0.000" "False" "31.381" "18" "7" "8" "7" "435" "49.6" "9.54" "25.66" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "MHC class II antigen presentation; EPH-ephrin mediated repulsion of cells; Potential therapeutics for SARS; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "21" "0" "1.015" "0.966" "1.016" "1.011" "0.957" "0.999" "1.021" "0.928" "0.983" "850.9" "863.5" "822.3" "864.6" "860.2" "814.5" "849.9" "868.7" "790.0" "836.3" "" "" "" "" "" "" "" "" "" "" "683.4" "623.1" "653.2" "579.3" "594.9" "611.1" "595.0" "634.4" "790.0" "680.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779285951144314922" "False" "High" "IsMasterProtein" "Q8IUH3" "RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1" "0.000" "False" "31.376" "9" "4" "8" "4" "476" "53.5" "7.17" "29.21" "4" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "129831" "ENSG00000155636" "RBM45" "hsa:129831; Q6NYL0; Q8IUH3; Q8NFC9" "" "" "0" "0" "0.950" "0.956" "1.087" "1.054" "0.990" "1.034" "1.068" "1.029" "1.037" "270.4" "256.8" "258.4" "293.8" "284.9" "267.7" "279.6" "288.7" "278.2" "280.5" "" "" "" "" "" "" "" "" "" "" "217.2" "185.3" "205.3" "196.9" "197.0" "200.9" "195.8" "210.8" "278.2" "228.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5966605329502245695" "False" "High" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "0.000" "False" "31.310" "31" "4" "25" "4" "105" "11.7" "4.92" "92.05" "4" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome" "20" "0" "1.052" "1.066" "1.142" "1.024" "1.061" "1.106" "1.170" "1.059" "1.043" "2174.5" "2288.4" "2317.1" "2484.3" "2226.1" "2307.4" "2404.8" "2545.1" "2302.5" "2268.5" "" "" "" "" "" "" "" "" "" "" "1746.5" "1651.2" "1840.5" "1664.5" "1539.6" "1731.2" "1683.7" "1858.7" "2302.5" "1844.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-348929784632102448" "False" "High" "IsMasterProtein" "O75306" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2" "0.000" "False" "31.301" "15" "6" "8" "6" "463" "52.5" "7.55" "30.12" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00346" "4720" "ENSG00000158864" "NDUFS2" "D3DVG7; hsa:4720; J3KPM7; O75306; Q5VTW0; Q969P3; Q9UEV3" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "1.158" "1.070" "1.081" "1.164" "1.090" "1.048" "1.127" "1.035" "1.088" "664.0" "768.9" "710.8" "717.6" "773.2" "723.8" "696.1" "748.4" "687.4" "722.4" "" "" "" "" "" "" "" "" "" "" "533.3" "554.8" "564.6" "480.8" "534.8" "543.0" "487.4" "546.6" "687.4" "587.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1607467674154274672" "False" "High" "IsMasterProtein" "Q8N4Q1" "Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1" "0.000" "False" "31.301" "24" "2" "7" "2" "142" "16.0" "4.31" "33.51" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "mitochondrion" "other molecular function" "Pf06747" "131474" "ENSG00000163528" "CHCHD4" "A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6" "Mitochondrial protein import" "" "1" "0" "1.090" "1.019" "1.032" "0.969" "1.096" "0.914" "0.920" "1.107" "1.000" "330.7" "360.5" "337.0" "341.2" "320.6" "362.3" "302.2" "304.2" "366.0" "330.8" "" "" "" "" "" "" "" "" "" "" "265.6" "260.1" "267.7" "228.6" "221.7" "271.8" "211.6" "222.1" "366.0" "269.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5319872679741064952" "False" "High" "IsMasterProtein" "P22570" "NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3" "0.000" "False" "31.265" "22" "9" "9" "9" "491" "53.8" "8.44" "28.67" "9" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "2232" "ENSG00000161513" "FDXR" "B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; hsa:2232; P22570; Q13716; Q4PJI0; Q9BU12" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "Iron-sulfur cluster biogenesis" "5" "0" "0.963" "1.024" "1.095" "1.046" "1.030" "1.015" "1.072" "1.081" "1.065" "716.2" "689.7" "733.5" "784.3" "749.0" "738.0" "726.8" "768.0" "774.6" "763.0" "" "" "" "" "" "" "" "" "" "" "575.3" "497.7" "582.7" "525.5" "518.0" "553.7" "508.9" "560.9" "774.6" "620.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7992266646399474025" "False" "High" "IsMasterProtein" "Q9Y605" "MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1" "0.000" "False" "31.261" "25" "2" "4" "2" "127" "14.6" "4.70" "21.76" "2" "" "nucleus;other cell component" "" "Pf15155" "93621" "ENSG00000179010" "MRFAP1" "B3KVT2; D3DVT3; hsa:93621; Q9Y605" "" "" "0" "0" "0.997" "0.900" "1.076" "1.099" "1.017" "1.042" "1.053" "1.049" "1.044" "235.1" "234.3" "211.6" "253.0" "258.3" "239.1" "245.0" "247.4" "246.6" "245.4" "" "" "" "" "" "" "" "" "" "" "188.8" "169.1" "168.1" "169.5" "178.7" "179.4" "171.5" "180.7" "246.6" "199.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6643122719444543200" "False" "High" "IsMasterProtein" "Q96CB8" "Integrator complex subunit 12 OS=Homo sapiens OX=9606 GN=INTS12 PE=1 SV=1" "0.000" "False" "31.243" "16" "7" "7" "7" "462" "48.8" "9.69" "26.26" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628" "57117" "ENSG00000138785" "INTS12" "B2RC48; hsa:57117; Q3B6Z3; Q96CB8; Q9HD71" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.991" "1.060" "0.965" "1.016" "1.069" "1.010" "1.029" "1.095" "1.070" "767.3" "760.2" "813.2" "740.4" "779.7" "819.9" "775.0" "789.7" "840.3" "820.8" "" "" "" "" "" "" "" "" "" "" "616.3" "548.5" "645.9" "496.1" "539.2" "615.2" "542.6" "576.7" "840.3" "667.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6197247688658885913" "False" "High" "IsMasterProtein" "Q8N1B4" "Vacuolar protein sorting-associated protein 52 homolog OS=Homo sapiens OX=9606 GN=VPS52 PE=1 SV=1" "0.000" "False" "31.222" "13" "9" "11" "9" "723" "82.2" "5.99" "31.57" "9" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04129, Pf20655" "6293" "ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590; ENSG00000228425; ENSG00000236014" "VPS52" "A2BF38; B0UZZ4; B4DNI9; hsa:6293; Q53GR4; Q5JPA0; Q5SQW1; Q8IUN6; Q8N1B4; Q9NPT5" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.115" "0.961" "1.132" "1.064" "1.067" "1.034" "1.013" "1.066" "1.036" "456.5" "509.2" "438.7" "516.6" "485.7" "487.0" "471.9" "462.4" "486.6" "472.8" "" "" "" "" "" "" "" "" "" "" "366.7" "367.4" "348.5" "346.1" "335.9" "365.4" "330.4" "337.7" "486.6" "384.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993572615210098163" "False" "High" "IsMasterProtein" "Q9UJV9" "Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2" "0.000" "False" "31.182" "15" "9" "9" "9" "622" "69.8" "6.84" "23.50" "9" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271" "51428" "ENSG00000183258" "DDX41" "B2RDC8; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9" "mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN" "5q35 copy number variation" "5" "0" "1.125" "1.128" "1.128" "1.066" "1.050" "1.011" "0.952" "1.039" "1.098" "428.9" "482.8" "483.8" "483.8" "457.3" "450.3" "433.6" "408.2" "445.7" "471.1" "" "" "" "" "" "" "" "" "" "" "344.5" "348.4" "384.3" "324.2" "316.3" "337.8" "303.6" "298.1" "445.7" "383.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1272084248319891202" "False" "High" "IsMasterProtein" "Q9UKB1" "F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1" "0.000" "False" "31.171" "11" "6" "8" "6" "542" "62.1" "7.12" "30.43" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf12125, Pf12937" "23291" "ENSG00000072803" "FBXW11" "B2RC98; hsa:23291; Q9P2S8; Q9P2S9; Q9UKB1; Q9Y4C6" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Regulation of PLK1 Activity at G2/M Transition; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "TNF-alpha signaling pathway; VEGFA-VEGFR2 signaling" "12" "0" "0.973" "1.019" "1.023" "0.991" "0.997" "0.963" "1.010" "0.958" "1.019" "671.9" "654.1" "684.4" "687.1" "665.6" "670.2" "646.9" "678.7" "643.9" "684.8" "" "" "" "" "" "" "" "" "" "" "539.6" "471.9" "543.6" "460.4" "460.3" "502.8" "453.0" "495.6" "643.9" "556.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494300980345175756" "False" "High" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "0.000" "False" "31.165" "17" "5" "7" "5" "325" "37.2" "8.05" "21.85" "5" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Primary focal segmental glomerulosclerosis (FSGS)" "3" "0" "1.038" "0.988" "1.104" "1.003" "0.983" "0.951" "1.017" "1.045" "1.021" "227.0" "235.6" "224.2" "250.7" "227.7" "223.2" "215.9" "230.9" "237.3" "231.7" "" "" "" "" "" "" "" "" "" "" "182.3" "170.0" "178.1" "168.0" "157.5" "167.4" "151.2" "168.6" "237.3" "188.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8527831482180649662" "False" "High" "IsMasterProtein" "Q8NCE2" "Myotubularin-related protein 14 OS=Homo sapiens OX=9606 GN=MTMR14 PE=1 SV=2" "0.000" "False" "31.141" "6" "3" "4" "3" "650" "72.2" "6.24" "19.51" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "" "64419" "ENSG00000163719" "MTMR14" "hsa:64419; Q0JTH5; Q0JU83; Q6PIZ4; Q6QE21; Q86VK9; Q8IYK1; Q8NCE2; Q8TCM7; Q9H6C0" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "" "2" "0" "0.927" "0.976" "0.955" "0.986" "0.916" "0.812" "0.889" "0.902" "0.956" "226.6" "210.0" "221.1" "216.3" "223.5" "207.6" "184.0" "201.5" "204.3" "216.5" "" "" "" "" "" "" "" "" "" "" "182.0" "151.5" "175.6" "144.9" "154.6" "155.8" "128.8" "147.1" "204.3" "176.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8641441660686703988" "False" "High" "IsMasterProtein" "O94868" "F-BAR and double SH3 domains protein 2 OS=Homo sapiens OX=9606 GN=FCHSD2 PE=1 SV=3" "0.000" "False" "31.140" "12" "7" "7" "7" "740" "84.2" "5.77" "23.60" "7" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611, Pf14604" "9873" "ENSG00000137478" "FCHSD2" "B4DNI3; hsa:9873; O94868; Q7L8J9; Q8WVM2; Q96FV7; Q9UF77" "" "" "0" "0" "0.965" "0.912" "0.991" "0.973" "0.947" "0.934" "0.981" "0.939" "1.006" "568.5" "548.4" "518.4" "563.6" "553.1" "538.3" "531.2" "557.6" "533.9" "571.8" "" "" "" "" "" "" "" "" "" "" "456.6" "395.7" "411.7" "377.6" "382.6" "403.9" "371.9" "407.2" "533.9" "465.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312562393160644927" "False" "High" "IsMasterProtein" "Q8WV22" "Non-structural maintenance of chromosomes element 1 homolog OS=Homo sapiens OX=9606 GN=NSMCE1 PE=1 SV=5" "0.000" "False" "31.127" "30" "7" "11" "7" "266" "30.8" "7.47" "32.60" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07574, Pf08746" "197370" "ENSG00000169189" "NSMCE1" "D3DWF6; hsa:197370; Q8WV22; Q9P045; Q9P049" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "1.057" "1.005" "1.136" "1.060" "1.036" "1.076" "0.983" "0.946" "0.996" "746.9" "789.4" "750.6" "848.2" "791.6" "773.5" "803.8" "734.4" "706.8" "743.7" "" "" "" "" "" "" "" "" "" "" "599.9" "569.6" "596.3" "568.3" "547.5" "580.4" "562.8" "536.4" "706.8" "604.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7071014728097244949" "False" "High" "IsMasterProtein" "Q9BW27" "Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1" "0.000" "False" "31.127" "12" "6" "6" "6" "656" "75.0" "5.55" "24.84" "6" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07575" "79902" "ENSG00000125450" "NUP85" "B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1" "Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "0.998" "0.981" "1.071" "1.042" "0.992" "0.972" "1.115" "1.028" "1.036" "463.6" "462.5" "454.7" "496.6" "483.2" "459.9" "450.6" "516.9" "476.6" "480.3" "" "" "" "" "" "" "" "" "" "" "372.4" "333.8" "361.2" "332.7" "334.2" "345.1" "315.5" "377.5" "476.6" "390.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "59184659773015562" "False" "High" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "0.000" "False" "31.104" "31" "6" "14" "6" "173" "18.8" "6.68" "40.62" "6" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "XBP1(S) activates chaperone genes" "" "1" "0" "0.975" "1.022" "1.019" "0.948" "1.010" "0.925" "0.937" "0.932" "0.931" "1402.4" "1367.0" "1432.8" "1429.1" "1329.8" "1415.9" "1296.7" "1314.7" "1307.1" "1305.4" "" "" "" "" "" "" "" "" "" "" "1126.4" "986.4" "1138.1" "957.5" "919.7" "1062.3" "907.9" "960.1" "1307.1" "1061.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7535964181824527260" "False" "High" "IsMasterProtein" "Q9H0E3" "Histone deacetylase complex subunit SAP130 OS=Homo sapiens OX=9606 GN=SAP130 PE=1 SV=1" "0.000" "False" "31.071" "9" "8" "10" "8" "1048" "110.3" "9.83" "21.14" "8" "other biological processes" "nucleus" "" "Pf16014" "79595" "ENSG00000136715" "SAP130" "B7ZLM3; C9K0X9; hsa:79595; Q4ZFV4; Q53T46; Q8WVW4; Q9H0E3; Q9H9G8" "HATs acetylate histones; NoRC negatively regulates rRNA expression" "" "2" "0" "1.002" "1.055" "1.082" "1.022" "1.032" "1.183" "1.183" "1.104" "1.020" "495.4" "496.5" "522.5" "535.9" "506.0" "511.4" "585.8" "586.1" "546.7" "505.2" "" "" "" "" "" "" "" "" "" "" "397.9" "358.2" "415.0" "359.1" "350.0" "383.7" "410.1" "428.0" "546.7" "410.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570011154676120481" "False" "High" "IsMasterProtein" "Q9NRF9" "DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1" "0.000" "False" "31.060" "39" "5" "12" "5" "147" "16.8" "4.74" "36.28" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54107" "ENSG00000148229" "POLE3" "hsa:54107; Q5W0U1; Q8N758; Q8NCE5; Q9NR32; Q9NRF9" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Activation of the pre-replicative complex; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "16" "0" "0.991" "0.890" "0.993" "0.905" "0.943" "0.957" "0.887" "0.880" "0.905" "448.8" "444.6" "399.6" "445.8" "406.4" "423.0" "429.4" "398.2" "394.9" "406.4" "" "" "" "" "" "" "" "" "" "" "360.5" "320.8" "317.4" "298.7" "281.1" "317.4" "300.7" "290.8" "394.9" "330.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6975409787188746590" "False" "High" "IsMasterProtein" "Q7L513" "Fc receptor-like A OS=Homo sapiens OX=9606 GN=FCRLA PE=1 SV=2" "0.000" "False" "31.024" "16" "5" "8" "5" "359" "38.9" "5.36" "31.88" "5" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13895" "84824" "ENSG00000132185" "FCRLA" "A0N0M1; A6NC03; A6NL20; F5H720; F8W743; G3V1J2; hsa:84824; Q5VXA1; Q5VXA2; Q5VXA3; Q5VXA4; Q5VXB0; Q5VXB1; Q7L513; Q8NEW4; Q8WXH3; Q96PC6; Q96PJ0; Q96PJ1; Q96PJ2; Q96PJ4; Q9BR57" "" "" "0" "0" "0.981" "1.050" "1.000" "1.033" "0.936" "0.988" "1.075" "1.068" "1.047" "233.7" "229.3" "245.4" "233.7" "241.3" "218.9" "230.8" "251.1" "249.5" "244.6" "" "" "" "" "" "" "" "" "" "" "187.7" "165.5" "194.9" "156.6" "166.9" "164.2" "161.6" "183.4" "249.5" "198.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5399791769626457574" "False" "High" "IsMasterProtein" "Q9UMS0" "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Homo sapiens OX=9606 GN=NFU1 PE=1 SV=2" "0.000" "False" "31.013" "21" "4" "6" "4" "254" "28.4" "5.07" "24.00" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf01106, Pf08712" "27247" "ENSG00000169599" "NFU1" "B4DUL9; hsa:27247; Q53QE5; Q6VNZ8; Q7Z5B1; Q7Z5B2; Q9UMS0; Q9Y322" "" "Iron-sulfur cluster biogenesis" "1" "0" "0.985" "1.016" "0.911" "0.947" "0.988" "0.976" "1.035" "0.970" "0.955" "748.4" "737.1" "760.4" "681.7" "708.6" "739.6" "730.7" "774.6" "726.1" "714.7" "" "" "" "" "" "" "" "" "" "" "601.1" "531.9" "604.0" "456.7" "490.1" "554.9" "511.6" "565.7" "726.1" "581.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3338073365584811594" "False" "High" "IsMasterProtein" "P83731" "Large ribosomal subunit protein eL24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "0.000" "False" "30.998" "25" "5" "15" "5" "157" "17.8" "11.25" "44.33" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.860" "1.006" "0.956" "0.953" "1.118" "1.143" "1.127" "1.143" "1.002" "2583.5" "2221.3" "2598.0" "2470.3" "2461.9" "2888.9" "2951.8" "2912.3" "2951.7" "2589.0" "" "" "" "" "" "" "" "" "" "" "2075.0" "1602.9" "2063.6" "1655.1" "1702.7" "2167.5" "2066.7" "2126.9" "2951.7" "2105.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012915059673315434" "False" "High" "IsMasterProtein" "Q9UBK8" "Methionine synthase reductase OS=Homo sapiens OX=9606 GN=MTRR PE=1 SV=4" "0.000" "False" "30.985" "6" "4" "5" "4" "698" "77.6" "6.49" "21.27" "4" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00175, Pf00258, Pf00667" "4552" "ENSG00000124275" "MTRR" "hsa:4552; O60471; Q32MA9; Q7Z4M8; Q9UBK8" "Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Male infertility; Spina bifida" "10" "0" "0.953" "0.905" "0.920" "0.942" "0.980" "0.915" "0.963" "0.967" "0.995" "608.8" "580.4" "551.1" "560.0" "573.7" "596.6" "556.8" "586.3" "588.6" "605.9" "" "" "" "" "" "" "" "" "" "" "489.0" "418.8" "437.8" "375.2" "396.8" "447.6" "389.9" "428.2" "588.6" "492.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6107269265140402008" "False" "High" "IsMasterProtein" "P10109" "Adrenodoxin, mitochondrial OS=Homo sapiens OX=9606 GN=FDX1 PE=1 SV=1" "0.000" "False" "30.970" "29" "5" "11" "5" "184" "19.4" "5.83" "37.33" "5" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00111" "2230" "ENSG00000137714" "FDX1" "B0YJ14; hsa:2230; P10109; Q53YD6" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "Iron-sulfur cluster biogenesis" "6" "0" "1.220" "1.151" "1.211" "1.111" "1.157" "1.158" "1.212" "1.156" "1.125" "871.6" "1063.8" "1003.0" "1055.4" "968.8" "1008.6" "1009.5" "1056.2" "1008.0" "980.9" "" "" "" "" "" "" "" "" "" "" "700.1" "767.6" "796.7" "707.1" "670.0" "756.8" "706.8" "771.3" "1008.0" "797.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545176652009721876" "False" "High" "IsMasterProtein" "Q9P013" "Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2" "0.000" "False" "30.966" "20" "5" "9" "5" "229" "26.6" "5.71" "33.09" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04889" "51503" "ENSG00000150316" "CWC15" "B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29" "mRNA Splicing - Major Pathway" "" "1" "0" "0.964" "1.045" "1.072" "1.061" "1.119" "1.021" "0.998" "1.020" "0.984" "722.8" "696.7" "755.4" "774.9" "766.6" "808.9" "737.8" "721.0" "737.3" "711.0" "" "" "" "" "" "" "" "" "" "" "580.5" "502.7" "600.0" "519.2" "530.2" "606.9" "516.6" "526.5" "737.3" "578.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5987314834012537405" "False" "High" "IsMasterProtein" "O60888" "Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2" "0.000" "False" "30.939" "22" "3" "12" "3" "179" "19.1" "5.50" "40.67" "3" "other biological processes" "other membranes" "other molecular function" "Pf03091" "51596" "ENSG00000112514; ENSG00000226492" "CUTA" "A2AB26; A2BEL4; hsa:51596; O60888; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9" "" "" "0" "0" "1.084" "1.021" "1.142" "1.016" "1.092" "1.031" "0.962" "1.016" "1.059" "330.8" "358.6" "337.6" "377.6" "336.1" "361.1" "341.0" "318.3" "335.9" "350.4" "" "" "" "" "" "" "" "" "" "" "265.7" "258.7" "268.2" "253.0" "232.4" "270.9" "238.7" "232.5" "335.9" "285.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208446995115017732" "False" "High" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "0.000" "False" "30.911" "17" "6" "9" "6" "455" "51.8" "6.35" "23.63" "6" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "0.964" "1.049" "0.998" "0.956" "1.024" "0.999" "0.979" "1.041" "1.036" "640.8" "617.7" "672.1" "639.8" "612.5" "656.4" "639.9" "627.5" "667.1" "663.6" "" "" "" "" "" "" "" "" "" "" "514.7" "445.7" "533.8" "428.7" "423.6" "492.5" "448.0" "458.3" "667.1" "539.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1699375806796057255" "False" "High" "IsMasterProtein" "Q6IA69" "Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3" "0.000" "False" "30.908" "10" "5" "6" "5" "706" "79.2" "6.44" "20.98" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00795, Pf02540" "55191" "ENSG00000172890" "NADSYN1" "B3KUU4; hsa:55191; Q6IA69; Q86SN2; Q9HA25; Q9NVM8" "Nicotinate metabolism" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways" "3" "0" "1.000" "0.966" "1.121" "0.996" "0.990" "1.004" "0.995" "1.017" "1.027" "571.0" "571.3" "551.7" "640.2" "568.9" "565.5" "573.5" "567.9" "580.9" "586.4" "" "" "" "" "" "" "" "" "" "" "458.6" "412.2" "438.2" "428.9" "393.4" "424.3" "401.5" "414.8" "580.9" "476.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2735556346422021928" "False" "High" "IsMasterProtein" "P53384" "Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2" "0.000" "False" "30.901" "20" "4" "7" "4" "320" "34.5" "5.33" "20.91" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "4682" "ENSG00000103274" "NUBP1" "hsa:4682; P53384; Q32M30; Q498A9; Q53FS7" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis" "2" "0" "0.980" "0.944" "0.949" "0.985" "0.973" "1.001" "1.044" "0.986" "0.984" "278.1" "272.6" "262.4" "263.8" "274.0" "270.4" "278.3" "290.4" "274.1" "273.6" "" "" "" "" "" "" "" "" "" "" "223.3" "196.7" "208.4" "176.7" "189.5" "202.9" "194.8" "212.1" "274.1" "222.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-299196629688227683" "False" "High" "IsMasterProtein" "Q9UGM6" "Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=WARS2 PE=1 SV=1" "0.000" "False" "30.886" "17" "4" "5" "4" "360" "40.1" "9.28" "18.97" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf00579" "10352" "ENSG00000116874" "WARS2" "B1ALR1; B2R9D4; hsa:10352; Q53FT4; Q5VUD2; Q86TQ0; Q9UGM6" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.040" "0.969" "1.123" "0.962" "0.972" "0.928" "1.032" "1.006" "0.991" "178.5" "185.7" "173.0" "200.5" "171.7" "173.5" "165.7" "184.2" "179.5" "177.0" "" "" "" "" "" "" "" "" "" "" "143.4" "134.0" "137.4" "134.3" "118.8" "130.2" "116.0" "134.5" "179.5" "143.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620775136701769242" "False" "High" "IsMasterProtein" "P61764" "Syntaxin-binding protein 1 OS=Homo sapiens OX=9606 GN=STXBP1 PE=1 SV=1" "0.000" "False" "30.855" "12" "6" "6" "6" "594" "67.5" "6.96" "21.76" "6" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00995" "6812" "ENSG00000136854" "STXBP1" "B1AM97; hsa:6812; P61764; Q28208; Q62759; Q64320; Q68CM6; Q96TG8" "Regulation of insulin secretion; Neurexins and neuroligins" "Synaptic vesicle pathway; Rett syndrome; EGF/EGFR signaling pathway; Insulin signaling; 15q11q13 copy number variation" "7" "0" "0.965" "0.940" "1.011" "1.056" "0.948" "1.063" "1.098" "1.036" "1.006" "492.2" "475.2" "462.6" "497.7" "519.6" "466.5" "523.3" "540.4" "509.9" "495.1" "" "" "" "" "" "" "" "" "" "" "395.4" "342.9" "367.5" "333.4" "359.3" "350.0" "366.4" "394.7" "509.9" "402.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2612054938348296953" "False" "High" "IsMasterProtein" "Q16595" "Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2" "0.000" "False" "30.843" "19" "3" "8" "3" "210" "23.1" "8.69" "27.22" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01491" "2395" "ENSG00000165060" "FXN" "A8MXJ6; C9JJ89; hsa:2395; O15545; O95656; Q15294; Q16595; Q5VZ01" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "3" "0" "0.977" "1.028" "0.991" "1.181" "1.261" "1.002" "1.167" "1.074" "1.024" "379.6" "371.1" "390.3" "376.3" "448.4" "478.6" "380.4" "443.1" "407.8" "388.8" "" "" "" "" "" "" "" "" "" "" "304.9" "267.8" "310.0" "252.1" "310.1" "359.1" "266.4" "323.6" "407.8" "316.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139955916062878316" "False" "High" "IsMasterProtein" "Q9BZ95" "Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1" "0.000" "False" "30.823" "6" "7" "9" "7" "1437" "161.5" "8.21" "28.63" "7" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf00856, Pf17907, Pf17982" "54904" "ENSG00000147548" "NSD3" "B7ZL11; D3DSX1; hsa:54904; Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9BZ95; Q9H2M8; Q9H9W9; Q9NXA6" "PKMTs methylate histone lysines" "" "1" "0" "1.039" "0.978" "1.177" "1.098" "1.051" "1.164" "1.230" "1.191" "1.171" "213.6" "222.0" "208.8" "251.5" "234.5" "224.5" "248.7" "262.7" "254.5" "250.1" "" "" "" "" "" "" "" "" "" "" "171.6" "160.2" "165.9" "168.5" "162.2" "168.4" "174.1" "191.9" "254.5" "203.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1200242617848963307" "False" "High" "IsMasterProtein" "P31749" "RAC-alpha serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT1 PE=1 SV=2" "0.000" "False" "30.819" "15" "6" "8" "5" "480" "55.7" "6.07" "18.65" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "207" "ENSG00000142208" "AKT1" "B2RAM5; B7Z5R1; hsa:207; P31749; Q9BWB6" "Deactivation of the beta-catenin transactivating complex; RAB GEFs exchange GTP for GDP on RABs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; Regulation of TP53 Degradation; Negative regulation of NOTCH4 signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Integrin signaling; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; MTOR signalling; FLT3 Signaling; eNOS activation; Regulation of TP53 Activity through Acetylation; KSRP (KHSRP) binds and destabilizes mRNA; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Cyclin A:Cdk2-associated events at S phase entry; CTLA4 inhibitory signaling; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; S1P receptor signal transduction; Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Endochondral ossification; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; 3q29 copy number variation syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Opioid receptor pathways; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; Roles of ceramides in development of insulin resistance; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Comprehensive IL-17A signaling; Acute myeloid leukemia; Sildenafil treatment; Primary ovarian insufficiency; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response; Estrogen signaling pathway; Toll-like receptor signaling pathway" "179" "0" "0.767" "0.993" "1.002" "0.974" "1.104" "0.872" "0.997" "0.941" "0.957" "87.7" "67.3" "87.1" "87.9" "85.4" "96.9" "76.5" "87.4" "82.6" "83.9" "" "" "" "" "" "" "" "" "" "" "70.5" "48.6" "69.2" "58.9" "59.1" "72.7" "53.6" "63.9" "82.6" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8075154103448429091" "False" "High" "IsMasterProtein" "O94927" "HAUS augmin-like complex subunit 5 OS=Homo sapiens OX=9606 GN=HAUS5 PE=1 SV=2" "0.000" "False" "30.787" "13" "7" "7" "7" "633" "71.6" "8.51" "22.82" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf14817" "23354" "ENSG00000249115" "HAUS5" "B2RXK1; hsa:23354; O94927; Q6P2P7; Q7L3D5; Q96CT8" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.007" "1.013" "1.060" "1.015" "0.971" "0.969" "1.133" "1.045" "1.084" "427.2" "430.2" "433.0" "453.1" "433.6" "414.7" "414.0" "484.1" "446.5" "463.1" "" "" "" "" "" "" "" "" "" "" "343.2" "310.4" "343.9" "303.6" "299.9" "311.2" "289.9" "353.5" "446.5" "376.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9163044576809599647" "False" "High" "IsMasterProtein" "P0DPB6" "DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1" "0.000" "False" "30.766" "43" "4" "7" "4" "133" "15.2" "5.80" "25.97" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "51082" "ENSG00000186184" "POLR1D" "hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0" "" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "4" "0" "1.084" "1.046" "1.051" "1.049" "0.964" "0.985" "0.990" "0.972" "1.013" "586.2" "635.5" "613.4" "616.1" "614.8" "565.4" "577.7" "580.3" "569.5" "593.6" "" "" "" "" "" "" "" "" "" "" "470.8" "458.6" "487.3" "412.8" "425.2" "424.2" "404.5" "423.8" "569.5" "482.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-437633753378296153" "False" "High" "IsMasterProtein" "Q9UKI8" "Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2" "0.000" "False" "30.765" "9" "9" "12" "4" "766" "86.6" "8.72" "42.94" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "9874" "ENSG00000198586" "TLK1" "B3KR15; B4DX87; hsa:9874; Q14150; Q8N591; Q9NYH2; Q9UKI8; Q9Y4F6" "" "miRNA regulation of DNA damage response; Pathways affected in adenoid cystic carcinoma; DNA damage response" "3" "0" "0.912" "0.850" "0.869" "0.891" "0.873" "0.894" "0.859" "0.859" "0.897" "454.4" "414.6" "386.2" "395.0" "404.7" "396.7" "406.1" "390.4" "390.2" "407.6" "" "" "" "" "" "" "" "" "" "" "364.9" "299.1" "306.8" "264.6" "279.9" "297.6" "284.3" "285.1" "390.2" "331.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075280951894741873" "False" "High" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "0.000" "False" "30.763" "34" "4" "9" "4" "134" "15.3" "4.53" "30.74" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.022" "1.062" "1.126" "0.995" "1.043" "1.028" "1.065" "1.065" "1.091" "306.0" "312.8" "324.9" "344.5" "304.4" "319.0" "314.4" "326.0" "325.9" "333.8" "" "" "" "" "" "" "" "" "" "" "245.8" "225.7" "258.0" "230.8" "210.5" "239.3" "220.1" "238.0" "325.9" "271.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1787588940823929001" "False" "High" "IsMasterProtein" "P61224" "Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1" "0.000" "False" "30.762" "43" "6" "6" "2" "184" "20.8" "5.78" "22.37" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5908" "ENSG00000127314" "RAP1B" "B2R5Z2; B4DQI8; B4DW74; B4DW94; hsa:5908; P09526; P61224; Q502X3; Q5TZR4; Q6DCA1; Q6LES0" "Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling" "26" "2" "0.874" "0.873" "0.940" "1.041" "0.996" "1.187" "1.044" "1.134" "0.980" "501.2" "437.8" "437.7" "471.3" "521.6" "499.3" "595.0" "523.4" "568.5" "491.0" "" "" "" "" "" "" "" "" "" "" "402.5" "315.9" "347.7" "315.8" "360.7" "374.6" "416.6" "382.3" "568.5" "399.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-200305812606160804" "False" "High" "IsMasterProtein" "Q3MHD2" "Protein LSM12 OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2" "0.000" "False" "30.754" "15" "3" "7" "3" "195" "21.7" "7.74" "27.50" "3" "" "other cell component" "nucleic acid binding activity" "Pf09793, Pf21166" "124801" "ENSG00000161654" "LSM12" "hsa:124801; Q3MHD2; Q86YB1; Q96NL5" "" "" "0" "0" "1.017" "0.993" "0.871" "0.903" "1.004" "0.853" "0.918" "0.957" "0.966" "515.6" "524.5" "512.0" "449.0" "465.5" "517.5" "440.0" "473.5" "493.3" "498.0" "" "" "" "" "" "" "" "" "" "" "414.2" "378.5" "406.7" "300.8" "322.0" "388.3" "308.1" "345.8" "493.3" "405.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "487381900913570393" "False" "High" "IsMasterProtein" "Q9H8Y8" "Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3" "0.000" "False" "30.717" "15" "5" "6" "5" "452" "47.1" "4.82" "21.00" "5" "cell organization and biogenesis;stress response;other biological processes" "other membranes;ER/Golgi" "" "Pf04495" "26003" "ENSG00000115806" "GORASP2" "B4DKT0; hsa:26003; Q53TE3; Q96I74; Q96K84; Q9H8Y8; Q9H946; Q9UFW4" "Golgi Cisternae Pericentriolar Stack Reorganization" "" "1" "0" "0.946" "0.952" "1.054" "1.007" "0.950" "0.884" "0.968" "0.959" "0.940" "807.1" "763.3" "768.0" "850.5" "813.1" "767.1" "713.8" "781.0" "774.2" "758.9" "" "" "" "" "" "" "" "" "" "" "648.2" "550.8" "610.0" "569.8" "562.3" "575.5" "499.8" "570.3" "774.2" "617.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8899762439150821704" "False" "High" "IsMasterProtein" "Q9H9Q4" "Non-homologous end-joining factor 1 OS=Homo sapiens OX=9606 GN=NHEJ1 PE=1 SV=1" "0.000" "False" "30.708" "14" "3" "4" "3" "299" "33.3" "5.97" "18.95" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09302" "79840" "ENSG00000187736" "NHEJ1" "B8ZZA4; hsa:79840; Q4ZFW7; Q6IA64; Q96JS9; Q9H9Q4" "Nonhomologous End-Joining (NHEJ)" "Non-homologous end joining; DNA repair pathways, full network" "3" "0" "1.117" "1.058" "1.001" "1.008" "0.987" "0.954" "1.060" "1.057" "1.027" "513.6" "573.5" "543.2" "513.9" "517.5" "506.9" "490.0" "544.6" "542.8" "527.4" "" "" "" "" "" "" "" "" "" "" "412.5" "413.9" "431.5" "344.3" "357.9" "380.3" "343.0" "397.7" "542.8" "428.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476306151852591039" "False" "High" "IsMasterProtein" "Q15102" "Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1" "0.000" "False" "30.660" "29" "7" "14" "7" "231" "25.7" "6.84" "27.68" "7" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13472" "5050" "ENSG00000079462" "PAFAH1B3" "hsa:5050; Q15102; Q53X88" "COPI-independent Golgi-to-ER retrograde traffic" "PAFAH1B1 copy number variation" "2" "0" "1.096" "1.039" "1.047" "1.314" "1.159" "1.330" "1.292" "1.229" "1.184" "252.3" "276.4" "262.2" "264.0" "331.5" "292.5" "335.5" "325.9" "310.0" "298.6" "" "" "" "" "" "" "" "" "" "" "202.6" "199.5" "208.2" "176.9" "229.3" "219.5" "234.9" "238.0" "310.0" "242.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723353511819689268" "False" "High" "IsMasterProtein" "Q92947" "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" "0.000" "False" "30.577" "13" "4" "7" "4" "438" "48.1" "8.06" "22.62" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "2639" "ENSG00000105607" "GCDH" "A8K2Z2; O14719; Q92947" "Lysine catabolism" "Fatty acid beta-oxidation; Tryptophan metabolism" "3" "0" "0.927" "0.964" "0.913" "0.960" "0.967" "0.975" "0.915" "0.956" "0.935" "434.2" "402.4" "418.5" "396.4" "417.0" "419.9" "423.3" "397.4" "415.3" "406.1" "" "" "" "" "" "" "" "" "" "" "348.8" "290.3" "332.4" "265.6" "288.4" "315.0" "296.4" "290.2" "415.3" "330.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969393992682693722" "False" "High" "IsMasterProtein" "Q9NUJ1" "Palmitoyl-protein thioesterase ABHD10, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1" "0.000" "False" "30.545" "24" "6" "8" "6" "306" "33.9" "8.57" "26.11" "6" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00561" "55347" "ENSG00000144827" "ABHD10" "B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1" "Glucuronidation" "" "1" "0" "0.996" "1.040" "0.963" "1.055" "0.995" "0.978" "0.931" "0.900" "0.963" "640.7" "638.4" "666.6" "616.7" "676.0" "637.8" "626.5" "596.4" "576.5" "616.8" "" "" "" "" "" "" "" "" "" "" "514.6" "460.7" "529.5" "413.2" "467.5" "478.5" "438.6" "435.5" "576.5" "501.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1688448728000248200" "False" "High" "IsMasterProtein" "Q9BZH6" "WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1" "0.000" "False" "30.534" "6" "7" "9" "7" "1224" "136.6" "6.92" "25.85" "7" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "55717" "ENSG00000120008" "WDR11" "hsa:55717; Q5VWA1; Q9BZH6; Q9P2J6" "RHOH GTPase cycle" "" "1" "0" "1.052" "1.014" "1.047" "1.056" "1.059" "0.981" "1.022" "1.071" "1.035" "689.2" "725.3" "698.8" "721.4" "727.6" "729.7" "676.3" "704.2" "738.2" "713.6" "" "" "" "" "" "" "" "" "" "" "553.6" "523.4" "555.1" "483.3" "503.2" "547.5" "473.5" "514.3" "738.2" "580.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211480978683405727" "False" "High" "IsMasterProtein" "O95232" "Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2" "0.000" "False" "30.534" "24" "10" "11" "10" "432" "51.4" "9.79" "28.63" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf03194" "51747" "ENSG00000108848" "LUC7L3" "B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7" "mRNA Splicing - Major Pathway" "" "1" "0" "1.004" "1.062" "1.017" "1.158" "1.095" "1.238" "1.315" "1.177" "1.119" "406.1" "407.9" "431.2" "412.9" "470.2" "444.5" "502.8" "534.0" "477.9" "454.7" "" "" "" "" "" "" "" "" "" "" "326.2" "294.3" "342.5" "276.6" "325.2" "333.5" "352.1" "390.0" "477.9" "369.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1654443810418690353" "False" "High" "IsMasterProtein" "Q9UJU2" "Lymphoid enhancer-binding factor 1 OS=Homo sapiens OX=9606 GN=LEF1 PE=1 SV=1" "0.000" "False" "30.527" "16" "6" "8" "6" "399" "44.2" "7.42" "26.68" "6" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf08347" "51176" "ENSG00000138795" "LEF1" "B4DG38; B7Z8E2; E9PDK3; hsa:51176; Q3ZCU4; Q9HAZ0; Q9UJU2" "Formation of paraxial mesoderm; Ca2+ pathway; Transcriptional regulation of granulopoiesis; Somitogenesis; Formation of axial mesoderm; Deactivation of the beta-catenin transactivating complex; Transcriptional Regulation by VENTX; Cardiogenesis; Germ layer formation at gastrulation; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Repression of WNT target genes" "Arrhythmogenic right ventricular cardiomyopathy; Endoderm differentiation; Mesodermal commitment pathway; Mesodermal commitment pathway; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Amplification and expansion of oncogenic pathways as metastatic traits; Canonical and non-canonical Notch signaling; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Effect of progerin on genes involved in progeria; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Hippo signaling regulation pathways; TGF-beta receptor signaling in skeletal dysplasias; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Acute myeloid leukemia; 11p11.2 copy number variation syndrome ; Cell lineage map for neuronal differentiation; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "41" "0" "1.176" "1.051" "1.096" "1.142" "1.136" "1.109" "1.152" "1.114" "1.096" "565.0" "664.6" "594.0" "619.1" "645.3" "641.9" "626.8" "651.0" "629.3" "619.0" "" "" "" "" "" "" "" "" "" "" "453.8" "479.5" "471.8" "414.8" "446.3" "481.6" "438.8" "475.5" "629.3" "503.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278234146555232268" "False" "High" "IsMasterProtein" "Q96BK5" "PIN2/TERF1-interacting telomerase inhibitor 1 OS=Homo sapiens OX=9606 GN=PINX1 PE=1 SV=2" "0.000" "False" "30.495" "18" "5" "5" "5" "328" "37.0" "9.60" "21.12" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01585" "54984" "ENSG00000254093; ENSG00000284764" "PINX1" "B2R9B1; hsa:54984; Q548A5; Q6QWG9; Q7Z7J8; Q96BK5; Q96QD7; Q9HBU7; Q9NWW2" "" "" "0" "0" "1.086" "1.123" "1.116" "1.143" "1.079" "1.228" "1.123" "1.095" "1.156" "584.1" "634.3" "655.9" "652.0" "667.8" "630.2" "717.3" "655.8" "639.4" "675.5" "" "" "" "" "" "" "" "" "" "" "469.1" "457.7" "521.0" "436.9" "461.9" "472.8" "502.2" "478.9" "639.4" "549.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447457189107336251" "False" "High" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "0.000" "False" "30.493" "33" "5" "8" "4" "162" "18.8" "8.66" "30.24" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "" "2" "0" "1.036" "0.980" "1.052" "1.050" "0.978" "0.987" "1.086" "1.028" "0.993" "758.4" "786.0" "743.6" "798.2" "796.7" "741.5" "748.8" "823.8" "779.9" "752.8" "" "" "" "" "" "" "" "" "" "" "609.1" "567.2" "590.6" "534.8" "551.0" "556.3" "524.3" "601.7" "779.9" "612.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678408440687391789" "False" "High" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "0.000" "False" "30.483" "42" "6" "10" "6" "167" "18.8" "8.95" "36.10" "6" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "1.073" "1.084" "1.049" "0.995" "1.032" "1.039" "1.022" "1.024" "1.030" "941.2" "1010.3" "1019.8" "986.9" "936.4" "971.4" "978.2" "961.5" "964.2" "969.4" "" "" "" "" "" "" "" "" "" "" "755.9" "729.0" "810.1" "661.3" "647.6" "728.8" "684.9" "702.2" "964.2" "788.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802815428408388451" "False" "High" "IsMasterProtein" "Q9UK99" "F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3" "0.000" "False" "30.476" "8" "3" "5" "3" "471" "54.5" "5.00" "19.66" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00646, Pf04379, Pf09346" "26273" "ENSG00000110429" "FBXO3" "B3KY16; D3DR05; hsa:26273; Q86X90; Q9H0V2; Q9NUX2; Q9UK99" "" "" "0" "0" "0.988" "0.819" "1.104" "1.173" "0.980" "0.923" "0.903" "0.951" "0.908" "151.4" "149.6" "124.0" "167.2" "177.6" "148.4" "139.8" "136.8" "144.1" "137.5" "" "" "" "" "" "" "" "" "" "" "121.6" "108.0" "98.5" "112.1" "122.8" "111.3" "97.9" "99.9" "144.1" "111.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974134927255505490" "False" "High" "IsMasterProtein" "Q6VY07" "Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2" "0.000" "False" "30.456" "8" "7" "7" "7" "963" "104.8" "7.74" "25.88" "7" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf10254" "55690" "ENSG00000175115" "PACS1" "hsa:55690; Q6PJY6; Q6PKB6; Q6VY07; Q7Z590; Q7Z5W4; Q8N8K6; Q96MW0; Q9NW92; Q9ULP5" "Nef mediated downregulation of MHC class I complex cell surface expression" "" "1" "0" "1.083" "1.017" "1.034" "1.007" "1.093" "0.932" "1.003" "1.038" "0.978" "586.2" "635.0" "596.3" "606.1" "590.0" "640.4" "546.3" "587.8" "608.5" "573.4" "" "" "" "" "" "" "" "" "" "" "470.8" "458.2" "473.7" "406.1" "408.0" "480.5" "382.5" "429.3" "608.5" "466.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7391762605629829309" "False" "High" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "0.000" "False" "30.453" "16" "7" "9" "7" "387" "44.7" "5.60" "29.21" "7" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "0.955" "0.998" "0.901" "0.932" "0.947" "0.851" "0.989" "0.992" "0.911" "1512.6" "1444.6" "1508.9" "1363.3" "1409.6" "1432.4" "1286.8" "1495.6" "1501.0" "1378.4" "" "" "" "" "" "" "" "" "" "" "1214.9" "1042.4" "1198.6" "913.4" "974.9" "1074.7" "901.0" "1092.3" "1501.0" "1121.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8417991388953307590" "False" "High" "IsMasterProtein" "O75064" "DENN domain-containing protein 4B OS=Homo sapiens OX=9606 GN=DENND4B PE=1 SV=4" "0.000" "False" "30.446" "6" "8" "8" "8" "1496" "163.7" "7.21" "27.80" "8" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "9909" "ENSG00000198837" "DENND4B" "hsa:9909; O75064; Q5T4K0" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.037" "1.031" "1.068" "1.050" "1.051" "1.034" "1.006" "1.013" "1.094" "587.3" "609.2" "605.5" "627.1" "616.5" "617.3" "607.2" "590.8" "595.2" "642.3" "" "" "" "" "" "" "" "" "" "" "471.7" "439.6" "480.9" "420.2" "426.4" "463.2" "425.1" "431.5" "595.2" "522.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7585773354798248656" "False" "High" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "0.000" "False" "30.443" "22" "4" "10" "4" "199" "21.5" "5.24" "28.83" "4" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "1.027" "1.045" "1.011" "0.983" "1.024" "1.015" "1.023" "1.017" "0.966" "754.6" "775.0" "788.2" "763.1" "741.9" "772.5" "766.2" "771.8" "767.2" "728.8" "" "" "" "" "" "" "" "" "" "" "606.0" "559.2" "626.1" "511.2" "513.1" "579.6" "536.4" "563.7" "767.2" "592.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8650097818779685703" "False" "High" "IsMasterProtein" "P62857" "Small ribosomal subunit protein eS28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "0.000" "False" "30.441" "46" "3" "14" "3" "69" "7.8" "10.70" "39.52" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.044" "1.184" "1.357" "1.271" "1.291" "1.438" "1.264" "1.300" "1.182" "481.3" "502.3" "569.6" "653.1" "611.9" "621.2" "692.2" "608.6" "625.5" "568.7" "" "" "" "" "" "" "" "" "" "" "386.6" "362.4" "452.4" "437.6" "423.2" "466.0" "484.6" "444.4" "625.5" "462.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3983028009750613022" "False" "High" "IsMasterProtein" "Q8N122" "Regulatory-associated protein of mTOR OS=Homo sapiens OX=9606 GN=RPTOR PE=1 SV=1" "0.000" "False" "30.429" "7" "7" "8" "7" "1335" "148.9" "6.89" "27.25" "7" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf02985, Pf14538" "57521" "ENSG00000141564" "RPTOR" "B2RN36; C6KEF2; F5H7J5; hsa:57521; Q8N122; Q8N4V9; Q8TB32; Q9P2P3" "Regulation of PTEN gene transcription; Amino acids regulate mTORC1; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "AMP-activated protein kinase signaling; Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; CAMKK2 pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "34" "0" "1.064" "1.016" "1.031" "1.095" "1.080" "1.047" "1.096" "1.042" "1.036" "511.2" "543.9" "519.4" "527.0" "559.6" "552.2" "535.2" "560.3" "532.7" "529.4" "" "" "" "" "" "" "" "" "" "" "410.6" "392.5" "412.6" "353.1" "387.0" "414.3" "374.7" "409.2" "532.7" "430.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6875111383431957192" "False" "High" "IsMasterProtein" "Q8IYW5" "E3 ubiquitin-protein ligase RNF168 OS=Homo sapiens OX=9606 GN=RNF168 PE=1 SV=1" "0.000" "False" "30.424" "14" "7" "8" "7" "571" "65.0" "7.96" "22.93" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097" "165918" "ENSG00000163961" "RNF168" "hsa:165918; Q8IYW5; Q8NA67; Q96NS4" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "8" "0" "1.103" "1.058" "0.920" "1.002" "1.016" "0.994" "1.096" "1.079" "1.054" "418.7" "461.7" "443.0" "385.3" "419.5" "425.2" "416.3" "459.1" "451.8" "441.5" "" "" "" "" "" "" "" "" "" "" "336.3" "333.2" "351.9" "258.1" "290.1" "319.0" "291.5" "335.3" "451.8" "359.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526425454586707099" "False" "High" "IsMasterProtein" "Q8TE02" "Elongator complex protein 5 OS=Homo sapiens OX=9606 GN=ELP5 PE=1 SV=3" "0.000" "False" "30.420" "20" "5" "6" "5" "300" "33.2" "4.98" "21.01" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10483" "23587" "ENSG00000170291; ENSG00000288485" "ELP5" "A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q8TE02; Q9BUB2; Q9Y2Q4" "HATs acetylate histones" "" "1" "0" "0.910" "0.946" "1.192" "1.035" "0.950" "1.196" "1.164" "1.004" "1.222" "366.1" "333.2" "346.2" "436.5" "378.9" "347.7" "437.9" "426.1" "367.6" "447.3" "" "" "" "" "" "" "" "" "" "" "294.1" "240.4" "275.0" "292.4" "262.0" "260.9" "306.6" "311.2" "367.6" "363.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3006741669515463279" "False" "High" "IsMasterProtein" "Q8WUD1" "Ras-related protein Rab-2B OS=Homo sapiens OX=9606 GN=RAB2B PE=1 SV=1" "0.000" "False" "30.336" "25" "5" "8" "1" "216" "24.2" "7.83" "27.83" "5" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "84932" "ENSG00000129472" "RAB2B" "B2RD03; D3DS24; hsa:84932; Q6NZ33; Q8WUD1" "RAB geranylgeranylation" "" "1" "0" "0.812" "0.812" "1.154" "0.984" "0.881" "1.088" "0.792" "0.840" "0.874" "57.3" "46.5" "46.5" "66.1" "56.4" "50.5" "62.3" "45.3" "48.1" "50.1" "" "" "" "" "" "" "" "" "" "" "46.0" "33.6" "37.0" "44.3" "39.0" "37.9" "43.6" "33.1" "48.1" "40.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676501743634657271" "False" "High" "IsMasterProtein" "P40855" "Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1" "0.000" "False" "30.333" "23" "6" "8" "6" "299" "32.8" "4.34" "25.02" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04614" "5824" "ENSG00000162735" "PEX19" "D3DVE7; E9PPB4; G3V3G9; hsa:5824; P40855; Q5QNY4; Q8NI97" "Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "TAR syndrome" "3" "0" "1.041" "1.047" "0.981" "0.947" "1.127" "1.056" "0.923" "1.034" "1.022" "250.0" "260.2" "261.7" "245.2" "236.6" "281.8" "264.0" "230.7" "258.4" "255.3" "" "" "" "" "" "" "" "" "" "" "200.8" "187.7" "207.9" "164.3" "163.6" "211.4" "184.8" "168.5" "258.4" "207.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613056624096108144" "False" "High" "IsMasterProtein" "Q7Z7E8" "Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens OX=9606 GN=UBE2Q1 PE=1 SV=1" "0.000" "False" "30.322" "20" "9" "9" "9" "422" "46.1" "5.10" "25.04" "9" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "55585" "ENSG00000160714" "UBE2Q1" "B4DF92; hsa:55585; Q29SN7; Q3B841; Q5I0X2; Q6IS04; Q6P7P2; Q7Z7E8; Q96MV4; Q9BVX5; Q9UGL6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.236" "0.974" "1.066" "1.042" "1.121" "1.006" "0.960" "1.063" "1.021" "498.3" "615.9" "485.3" "531.0" "519.3" "558.6" "501.2" "478.6" "529.5" "508.8" "" "" "" "" "" "" "" "" "" "" "400.2" "444.4" "385.5" "355.8" "359.2" "419.1" "350.9" "349.5" "529.5" "413.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794813676372242912" "False" "High" "IsMasterProtein" "Q96MW5" "Conserved oligomeric Golgi complex subunit 8 OS=Homo sapiens OX=9606 GN=COG8 PE=1 SV=2" "0.000" "False" "30.320" "14" "9" "11" "9" "612" "68.4" "5.20" "33.49" "9" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf04124" "84342" "ENSG00000213380" "COG8" "hsa:84342; Q0VAK2; Q8WVV6; Q96MW5; Q9H6F8" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "0.992" "1.017" "1.126" "1.118" "1.044" "1.004" "1.029" "1.061" "1.045" "774.7" "768.9" "787.6" "872.4" "865.8" "808.6" "777.8" "797.2" "821.9" "809.5" "" "" "" "" "" "" "" "" "" "" "622.2" "554.8" "625.6" "584.5" "598.8" "606.6" "544.6" "582.2" "821.9" "658.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4298882931648225908" "False" "High" "IsMasterProtein" "Q9UGJ1" "Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1" "0.000" "False" "30.305" "11" "6" "7" "6" "667" "76.0" "6.65" "25.24" "6" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cytoplasmic organelle" "cytoskeletal activity" "Pf04130, Pf17681" "27229" "ENSG00000137822" "TUBGCP4" "B3KNK6; hsa:27229; Q969X3; Q9NVF0; Q9UGJ1" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "0.863" "0.888" "0.928" "0.891" "1.078" "1.014" "0.962" "1.013" "1.058" "214.2" "184.9" "190.3" "198.7" "190.8" "231.0" "217.3" "206.2" "216.9" "226.7" "" "" "" "" "" "" "" "" "" "" "172.1" "133.4" "151.2" "133.2" "132.0" "173.3" "152.1" "150.6" "216.9" "184.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4910055014827061803" "False" "High" "IsMasterProtein" "Q14653" "Interferon regulatory factor 3 OS=Homo sapiens OX=9606 GN=IRF3 PE=1 SV=1" "0.000" "False" "30.291" "16" "5" "7" "5" "427" "47.2" "5.34" "21.15" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3661" "ENSG00000126456" "IRF3" "A8K7L2; B2RAZ3; hsa:3661; Q14653; Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; ISG15 antiviral mechanism; Interferon gamma signaling; Interferon alpha/beta signaling; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; IRF3 mediated activation of type 1 IFN" "Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Fibrin complement receptor 3 signaling pathway; White fat cell differentiation; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Urotensin-II-mediated signaling pathway; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; Toll-like receptor signaling pathway" "38" "0" "1.034" "1.107" "1.118" "1.072" "1.012" "0.888" "0.906" "0.981" "1.059" "207.5" "214.6" "229.7" "232.1" "222.5" "210.0" "184.2" "188.1" "203.5" "219.8" "" "" "" "" "" "" "" "" "" "" "166.7" "154.8" "182.5" "155.5" "153.9" "157.5" "129.0" "137.4" "203.5" "178.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-126462466589207022" "False" "High" "IsMasterProtein" "P18440" "Arylamine N-acetyltransferase 1 OS=Homo sapiens OX=9606 GN=NAT1 PE=1 SV=2" "0.000" "False" "30.243" "26" "7" "8" "7" "290" "33.9" "6.54" "28.93" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf00797" "9" "ENSG00000171428" "NAT1" "A8K4E7; hsa:9; O15159; O15300; P18440; Q546N1; Q96TE9" "Paracetamol ADME; Acetylation" "Omega-6-fatty acids in senescence; Arylamine metabolism; Metapathway biotransformation Phase I and II" "5" "0" "0.999" "0.960" "0.938" "1.015" "1.047" "1.015" "0.906" "1.001" "0.988" "388.6" "388.3" "373.1" "364.4" "394.6" "406.9" "394.4" "352.2" "389.1" "384.1" "" "" "" "" "" "" "" "" "" "" "312.1" "280.2" "296.4" "244.2" "272.9" "305.3" "276.1" "257.2" "389.1" "312.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163980209620091115" "False" "High" "IsMasterProtein" "O43598" "5-hydroxymethyl-dUMP N-hydrolase OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "0.000" "False" "30.201" "35" "4" "9" "4" "174" "19.1" "5.05" "33.54" "4" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "Purine catabolism" "" "1" "0" "1.005" "1.040" "1.166" "1.093" "1.017" "1.041" "0.977" "0.974" "0.990" "464.0" "466.1" "482.4" "540.9" "506.9" "472.1" "483.1" "453.1" "451.7" "459.4" "" "" "" "" "" "" "" "" "" "" "372.7" "336.3" "383.1" "362.4" "350.6" "354.2" "338.2" "330.9" "451.7" "373.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3725615404801325538" "False" "High" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=5" "0.000" "False" "30.197" "13" "7" "8" "7" "565" "63.1" "5.72" "27.87" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13181" "" "ENSG00000196510" "ANAPC7" "Q96AC4; Q96GF4; Q9BU24; Q9NT16; Q9UJX3" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.015" "1.031" "0.964" "0.975" "0.972" "0.902" "0.992" "1.019" "0.964" "696.0" "706.1" "717.7" "670.7" "678.3" "676.8" "627.7" "690.1" "709.4" "670.8" "" "" "" "" "" "" "" "" "" "" "559.0" "509.5" "570.1" "449.4" "469.1" "507.8" "439.5" "504.0" "709.4" "545.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7090269578477503572" "False" "High" "IsMasterProtein" "P29353" "SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4" "0.000" "False" "30.187" "13" "6" "6" "6" "583" "62.8" "6.44" "21.61" "6" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00640" "6464" "ENSG00000160691" "SHC1" "B5BU19; D3DV78; hsa:6464; O15290; P29353; Q5T180; Q5T183; Q5T184; Q5T185; Q5T186; Q8N4K5; Q96CL1" "Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "65" "0" "0.963" "1.083" "1.144" "1.067" "1.045" "1.021" "1.135" "1.037" "1.060" "547.1" "526.6" "592.2" "626.1" "583.5" "571.9" "558.5" "621.0" "567.3" "579.7" "" "" "" "" "" "" "" "" "" "" "439.4" "380.0" "470.4" "419.5" "403.6" "429.1" "391.0" "453.5" "567.3" "471.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8502957251701712576" "False" "High" "IsMasterProtein" "Q9UHW5" "GPN-loop GTPase 3 OS=Homo sapiens OX=9606 GN=GPN3 PE=1 SV=2" "0.000" "False" "30.118" "22" "4" "7" "4" "284" "32.7" "4.50" "19.34" "4" "" "other cell component" "other molecular function" "Pf03029" "51184" "ENSG00000111231" "GPN3" "B2RC54; D4YWV1; F5H759; hsa:51184; Q53FS3; Q6UVZ6; Q7Z3D3; Q8NEI2; Q96HK9; Q9UHW5" "" "" "0" "0" "0.960" "0.853" "1.108" "1.036" "0.981" "0.996" "1.068" "0.964" "1.053" "274.2" "263.2" "233.9" "303.8" "284.2" "269.0" "273.1" "292.9" "264.4" "288.8" "" "" "" "" "" "" "" "" "" "" "220.3" "189.9" "185.8" "203.5" "196.5" "201.8" "191.2" "213.9" "264.4" "234.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5853240527723212968" "False" "High" "IsMasterProtein" "Q9H7Z7" "Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1" "0.000" "False" "30.112" "16" "5" "7" "5" "377" "41.9" "9.16" "26.32" "5" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf13410, Pf13417" "80142" "ENSG00000148334" "PTGES2" "hsa:80142; Q53EW9; Q5SYV6; Q96GI0; Q96GL2; Q9H7Z7" "Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Relationship between inflammation, COX-2 and EGFR; Omega-6-fatty acids in senescence" "4" "0" "1.051" "1.010" "0.965" "0.997" "0.980" "0.957" "0.978" "1.005" "0.999" "893.3" "939.2" "901.9" "862.1" "891.0" "875.1" "855.0" "873.8" "898.0" "892.1" "" "" "" "" "" "" "" "" "" "" "717.5" "677.7" "716.4" "577.6" "616.2" "656.6" "598.6" "638.2" "898.0" "725.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444785854763805629" "False" "High" "IsMasterProtein" "O15550" "Lysine-specific demethylase 6A OS=Homo sapiens OX=9606 GN=KDM6A PE=1 SV=2" "0.000" "False" "30.089" "5" "7" "10" "4" "1401" "154.1" "7.44" "29.54" "7" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02373, Pf13181, Pf21322, Pf21326" "7403" "ENSG00000147050" "KDM6A" "hsa:7403; O15550; Q52LL9; Q5JVQ7" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones; Chromatin modifications during the maternal to zygotic transition (MZT)" "Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma; Kleefstra syndrome" "9" "1" "1.036" "0.982" "0.984" "0.979" "0.972" "0.913" "0.952" "0.984" "0.983" "279.6" "289.6" "274.6" "275.3" "273.8" "271.7" "255.4" "266.2" "275.3" "274.8" "" "" "" "" "" "" "" "" "" "" "224.6" "208.9" "218.2" "184.4" "189.4" "203.9" "178.8" "194.4" "275.3" "223.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8210818149912646419" "False" "High" "IsMasterProtein" "P11216" "Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5" "0.000" "False" "30.071" "9" "9" "12" "8" "843" "96.6" "6.86" "32.01" "9" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00343" "5834" "ENSG00000100994" "PYGB" "hsa:5834; P11216; Q96AK1; Q9NPX8" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "IL-18 signaling pathway; Glycogen synthesis and degradation" "4" "1" "0.943" "0.928" "0.911" "1.096" "1.054" "1.095" "0.966" "1.045" "1.014" "779.0" "734.2" "722.8" "709.7" "853.8" "821.5" "853.1" "752.7" "814.1" "789.6" "" "" "" "" "" "" "" "" "" "" "625.7" "529.8" "574.1" "475.5" "590.5" "616.3" "597.3" "549.7" "814.1" "642.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2645630736488314632" "False" "High" "IsMasterProtein" "P04080" "Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2" "0.000" "False" "30.038" "34" "3" "10" "3" "98" "11.1" "7.56" "47.01" "3" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1476" "ENSG00000160213" "CSTB" "hsa:1476; P04080" "Neutrophil degranulation" "" "1" "0" "0.967" "1.048" "0.903" "0.881" "1.080" "0.927" "1.013" "0.949" "0.986" "518.9" "501.9" "543.6" "468.3" "457.3" "560.6" "480.8" "525.8" "492.2" "511.7" "" "" "" "" "" "" "" "" "" "" "416.7" "362.2" "431.8" "313.7" "316.3" "420.6" "336.6" "384.0" "492.2" "416.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6467566476375476721" "False" "High" "IsMasterProtein" "Q03154" "Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1" "0.000" "False" "30.016" "26" "7" "8" "7" "408" "45.9" "6.18" "21.87" "7" "other metabolic processes" "non-structural extracellular;cytosol" "other molecular function" "Pf01546, Pf07687" "95" "ENSG00000243989" "ACY1" "C9J6I6; C9J9D8; C9JWD4; hsa:95; Q03154" "Aflatoxin activation and detoxification; Paracetamol ADME; Defective ACY1 causes encephalopathy" "Thyroxine (thyroid hormone) production" "4" "0" "1.068" "1.055" "1.076" "1.096" "1.103" "1.054" "1.015" "1.031" "1.079" "568.6" "607.1" "600.2" "612.0" "623.0" "627.0" "599.3" "577.3" "586.5" "613.3" "" "" "" "" "" "" "" "" "" "" "456.7" "438.0" "476.7" "410.0" "430.8" "470.5" "419.6" "421.6" "586.5" "498.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2031700092780878303" "False" "High" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "0.000" "False" "29.996" "45" "4" "9" "4" "95" "10.5" "8.18" "25.04" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "Mitochondrial protein import" "" "1" "0" "1.230" "1.160" "1.216" "1.114" "1.159" "1.101" "1.049" "1.150" "1.156" "679.5" "835.8" "788.5" "826.4" "756.9" "787.5" "747.9" "712.7" "781.6" "785.3" "" "" "" "" "" "" "" "" "" "" "545.8" "603.1" "626.3" "553.7" "523.5" "590.9" "523.6" "520.5" "781.6" "638.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-27127465578060112" "False" "High" "IsMasterProtein" "Q96SU4" "Oxysterol-binding protein-related protein 9 OS=Homo sapiens OX=9606 GN=OSBPL9 PE=1 SV=2" "0.000" "False" "29.981" "12" "7" "7" "7" "736" "83.1" "6.18" "22.04" "7" "other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114883" "ENSG00000117859" "OSBPL9" "B1AKJ8; B3KPQ4; D3DQ31; hsa:114883; Q5TFC0; Q6IA67; Q86YQ3; Q8NB17; Q8TAS8; Q96SK4; Q96SU4; Q9H9X2" "Synthesis of bile acids and bile salts" "" "1" "0" "0.994" "0.948" "0.933" "0.898" "0.904" "0.909" "0.937" "0.884" "0.934" "716.6" "712.6" "679.0" "668.8" "643.7" "647.8" "651.8" "671.6" "633.7" "669.4" "" "" "" "" "" "" "" "" "" "" "575.6" "514.2" "539.4" "448.1" "445.2" "486.0" "456.3" "490.5" "633.7" "544.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3096317975956610268" "False" "High" "IsMasterProtein" "Q9HBL8" "NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1" "0.000" "False" "29.980" "32" "9" "9" "9" "299" "33.3" "7.52" "25.53" "9" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf05368" "57407" "ENSG00000153406; ENSG00000274684" "NMRAL1" "hsa:57407; Q9HBL8" "Urea cycle" "" "1" "0" "0.997" "0.992" "1.008" "0.964" "0.958" "0.922" "0.942" "0.913" "0.970" "670.2" "668.0" "664.6" "675.7" "645.9" "642.0" "617.9" "631.2" "612.1" "650.5" "" "" "" "" "" "" "" "" "" "" "538.3" "482.0" "527.9" "452.7" "446.7" "481.7" "432.6" "461.0" "612.1" "529.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9146953398004624321" "False" "High" "IsMasterProtein" "Q00613" "Heat shock factor protein 1 OS=Homo sapiens OX=9606 GN=HSF1 PE=1 SV=1" "0.000" "False" "29.925" "13" "6" "9" "5" "529" "57.2" "5.19" "28.78" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00447, Pf06546" "3297" "ENSG00000185122; ENSG00000284774" "HSF1" "A8K4L0; A8MW26; hsa:3297; Q00613; Q53XT4" "Regulation of HSF1-mediated heat shock response; Attenuation phase; Aggrephagy; HSF1 activation" "10q11.21q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "7" "0" "1.052" "1.014" "1.013" "1.001" "0.977" "0.891" "0.965" "0.907" "0.994" "944.6" "993.6" "957.4" "956.6" "945.4" "922.9" "841.9" "911.5" "856.8" "938.5" "" "" "" "" "" "" "" "" "" "" "758.7" "716.9" "760.5" "640.9" "653.9" "692.4" "589.5" "665.7" "856.8" "763.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2341580766278944773" "False" "High" "IsMasterProtein" "P15056" "Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4" "0.000" "False" "29.911" "9" "7" "8" "3" "766" "84.4" "7.53" "25.99" "7" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "673" "ENSG00000157764" "BRAF" "A4D1T4; B6HY61; B6HY62; B6HY63; B6HY64; B6HY65; B6HY66; hsa:673; P15056; Q13878; Q3MIN6; Q9UDP8; Q9Y6T3" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Spry regulation of FGF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; Signalling to p38 via RIT and RIN; Negative feedback regulation of MAPK pathway" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Polycystic kidney disease pathway; Bladder cancer; Focal adhesion; BDNF-TrkB signaling; MAPK signaling pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Rett syndrome; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; MAPK pathway in congenital thyroid cancer; TCA cycle in senescence; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; ErbB signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "56" "1" "1.053" "1.086" "0.944" "0.992" "1.067" "0.933" "1.031" "0.983" "1.072" "701.6" "738.6" "761.8" "662.1" "695.7" "749.0" "654.6" "723.6" "689.8" "751.9" "" "" "" "" "" "" "" "" "" "" "563.5" "532.9" "605.1" "443.6" "481.1" "561.9" "458.3" "528.4" "689.8" "611.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772663144839085983" "False" "High" "IsMasterProtein" "O14965" "Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=3" "0.000" "False" "29.901" "19" "8" "11" "7" "403" "45.8" "9.39" "37.98" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6790" "ENSG00000087586" "AURKA" "E1P5F9; hsa:6790; O14965; O60445; O75873; Q9BQD6; Q9UPG5" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA" "Gastric cancer network 1; EGF/EGFR signaling pathway; p53 transcriptional gene network; HDAC6 interactions in the central nervous system" "12" "0" "1.004" "1.077" "1.087" "1.053" "0.992" "0.982" "0.870" "0.939" "1.073" "428.6" "430.4" "461.8" "466.0" "451.5" "425.3" "420.8" "372.7" "402.4" "460.1" "" "" "" "" "" "" "" "" "" "" "344.2" "310.6" "366.8" "312.2" "312.3" "319.1" "294.6" "272.2" "402.4" "374.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472433998448837783" "False" "High" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "0.000" "False" "29.899" "22" "6" "8" "5" "286" "33.7" "9.36" "28.52" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "RHOJ GTPase cycle; RHOH GTPase cycle" "" "2" "0" "1.064" "1.034" "0.986" "0.998" "1.073" "0.938" "1.027" "1.032" "1.055" "631.8" "672.4" "653.2" "623.2" "630.6" "678.2" "592.9" "648.8" "652.1" "666.8" "" "" "" "" "" "" "" "" "" "" "507.5" "485.2" "518.9" "417.5" "436.1" "508.8" "415.1" "473.8" "652.1" "542.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8480986397388579687" "False" "High" "IsMasterProtein" "Q9UBB9" "Tuftelin-interacting protein 11 OS=Homo sapiens OX=9606 GN=TFIP11 PE=1 SV=1" "0.000" "False" "29.883" "11" "7" "7" "7" "837" "96.8" "5.67" "23.77" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "extracellular matrix;nucleus;other cell component" "nucleic acid binding activity" "Pf01585, Pf07842, Pf12457" "24144" "ENSG00000100109" "TFIP11" "hsa:24144; O95908; Q20WL0; Q5H8V8; Q9UBB9; Q9UGV7; Q9Y2Q8" "mRNA Splicing - Major Pathway" "" "1" "0" "0.881" "1.114" "0.881" "0.985" "0.953" "1.048" "0.913" "1.112" "1.008" "180.1" "158.8" "200.7" "158.7" "177.4" "171.8" "188.8" "164.5" "200.2" "181.5" "" "" "" "" "" "" "" "" "" "" "144.7" "114.6" "159.4" "106.3" "122.7" "128.9" "132.2" "120.1" "200.2" "147.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-228772176721817864" "False" "High" "IsMasterProtein" "Q96HY6" "DDRGK domain-containing protein 1 OS=Homo sapiens OX=9606 GN=DDRGK1 PE=1 SV=2" "0.000" "False" "29.881" "17" "4" "5" "4" "314" "35.6" "5.12" "16.75" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09756" "65992" "ENSG00000198171" "DDRGK1" "A6NIU5; C9JSZ5; hsa:65992; Q96HY6; Q9BW47" "RHOA GTPase cycle" "" "1" "0" "1.289" "1.152" "1.451" "1.207" "1.173" "1.191" "1.185" "1.328" "1.206" "35.9" "46.2" "41.3" "52.0" "43.3" "42.1" "42.7" "42.5" "47.6" "43.3" "" "" "" "" "" "" "" "" "" "" "28.8" "33.4" "32.8" "34.9" "29.9" "31.6" "29.9" "31.0" "47.6" "35.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945964816553277045" "False" "High" "IsMasterProtein" "Q9Y2X0" "Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2" "0.000" "False" "29.823" "8" "7" "7" "7" "877" "96.7" "7.37" "25.14" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00400, Pf11635, Pf20718, Pf20719" "10025" "ENSG00000175221" "MED16" "hsa:10025; Q6PJT2; Q96AD4; Q96I35; Q9Y2X0; Q9Y652" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.036" "1.037" "1.019" "1.047" "1.057" "1.055" "1.072" "1.094" "1.119" "800.9" "829.6" "830.6" "816.5" "838.3" "846.3" "844.6" "858.6" "876.1" "895.9" "" "" "" "" "" "" "" "" "" "" "643.3" "598.6" "659.8" "547.0" "579.7" "635.0" "591.3" "627.1" "876.1" "728.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1767684544015944843" "False" "High" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "0.000" "False" "29.812" "25" "7" "18" "7" "240" "24.6" "11.19" "54.90" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.023" "1.026" "0.979" "0.944" "0.941" "0.804" "0.899" "0.875" "0.863" "936.3" "958.0" "960.5" "916.7" "884.1" "881.0" "752.8" "841.6" "819.4" "807.6" "" "" "" "" "" "" "" "" "" "" "752.1" "691.3" "763.0" "614.2" "611.4" "661.0" "527.1" "614.6" "819.4" "656.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008676394331225875" "False" "High" "IsMasterProtein" "Q9ULV3" "Cip1-interacting zinc finger protein OS=Homo sapiens OX=9606 GN=CIZ1 PE=1 SV=2" "0.000" "False" "29.772" "14" "9" "9" "9" "898" "100.0" "6.11" "19.28" "9" "other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "25792" "ENSG00000148337" "CIZ1" "A8K9J8; B4E131; B7ZAS8; hsa:25792; Q5SYW3; Q5SYW5; Q8WU72; Q9H868; Q9NYM8; Q9UHK4; Q9ULV3; Q9Y3F9; Q9Y3G0" "" "" "0" "0" "1.018" "1.025" "1.012" "0.909" "1.009" "0.891" "0.971" "0.956" "1.016" "627.9" "639.4" "643.2" "635.6" "570.6" "633.6" "559.6" "610.0" "600.5" "637.9" "" "" "" "" "" "" "" "" "" "" "504.3" "461.4" "511.0" "425.8" "394.6" "475.4" "391.8" "445.5" "600.5" "518.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-705908850981217680" "False" "High" "IsMasterProtein" "Q9NWZ5" "Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2" "0.000" "False" "29.668" "17" "8" "8" "8" "548" "61.1" "7.36" "22.22" "8" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00485, Pf14681" "54963" "ENSG00000198276" "UCKL1" "B7Z8N2; hsa:54963; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2; Q9NWZ5" "Pyrimidine salvage" "Pyrimidine metabolism" "2" "0" "1.133" "1.027" "1.162" "1.131" "1.104" "1.159" "1.122" "1.062" "1.015" "281.5" "319.1" "289.2" "327.1" "318.5" "310.9" "326.2" "315.9" "299.1" "285.6" "" "" "" "" "" "" "" "" "" "" "226.1" "230.3" "229.7" "219.2" "220.3" "233.3" "228.4" "230.7" "299.1" "232.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894400129343683729" "False" "High" "IsMasterProtein" "Q9BUH6" "Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2" "0.000" "False" "29.661" "40" "6" "7" "6" "204" "21.6" "5.48" "18.95" "6" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf15384" "286257" "ENSG00000148362" "PAXX" "hsa:286257; Q8IY19; Q9BUH6" "" "" "0" "0" "1.032" "1.045" "1.133" "1.144" "1.080" "1.175" "1.092" "1.083" "1.103" "303.0" "312.7" "316.7" "343.5" "346.8" "327.3" "356.0" "330.9" "328.3" "334.3" "" "" "" "" "" "" "" "" "" "" "243.4" "225.6" "251.6" "230.1" "239.9" "245.5" "249.2" "241.7" "328.3" "271.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8347343991909543181" "False" "High" "IsMasterProtein" "P48200" "Iron-responsive element-binding protein 2 OS=Homo sapiens OX=9606 GN=IREB2 PE=1 SV=4" "0.000" "False" "29.643" "9" "10" "11" "10" "963" "105.0" "7.05" "28.90" "10" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "3658" "ENSG00000136381" "IREB2" "A0A0A6YY96; A8KAC7; E1CJT9; H0YKU0; hsa:3658; P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17" "Iron uptake and transport" "Iron metabolism in placenta; Ferroptosis" "3" "0" "1.068" "1.027" "0.982" "1.010" "1.012" "0.998" "0.976" "1.028" "1.060" "798.5" "853.0" "820.3" "784.3" "806.7" "808.0" "797.0" "779.4" "820.8" "846.6" "" "" "" "" "" "" "" "" "" "" "641.3" "615.5" "651.6" "525.5" "557.9" "606.2" "558.0" "569.2" "820.8" "688.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5610453000666898366" "False" "High" "IsMasterProtein" "Q6RFH5" "WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1" "0.000" "False" "29.603" "19" "6" "6" "6" "385" "42.4" "8.32" "17.26" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "54663" "ENSG00000133316" "WDR74" "A8K8G5; hsa:54663; Q6RFH5; Q9BRC9; Q9H6X8; Q9NVY2" "" "" "0" "0" "1.073" "1.095" "1.073" "1.116" "1.005" "1.153" "1.132" "1.058" "1.047" "229.1" "245.9" "251.0" "245.9" "255.8" "230.3" "264.1" "259.3" "242.5" "239.9" "" "" "" "" "" "" "" "" "" "" "184.0" "177.4" "199.3" "164.8" "176.9" "172.8" "184.9" "189.4" "242.5" "195.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7444936349459715889" "False" "High" "IsMasterProtein" "Q32P28" "Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2" "0.000" "False" "29.601" "9" "6" "7" "6" "736" "83.3" "5.14" "24.92" "6" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13640" "64175" "ENSG00000117385" "P3H1" "hsa:64175; Q32P28; Q7KZR4; Q96BR8; Q96SK8; Q96SL5; Q96SN3; Q9H6K3; Q9HC86; Q9HC87" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "1.023" "0.905" "1.088" "1.034" "0.985" "1.044" "0.978" "1.043" "1.003" "618.2" "632.3" "559.7" "672.8" "639.5" "608.9" "645.5" "604.6" "644.6" "620.2" "" "" "" "" "" "" "" "" "" "" "496.5" "456.3" "444.6" "450.8" "442.3" "456.9" "451.9" "441.5" "644.6" "504.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2918128559095144433" "False" "High" "IsMasterProtein" "Q9NRA8" "Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2" "0.000" "False" "29.591" "7" "7" "9" "7" "985" "108.1" "8.32" "24.69" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10477" "56478" "ENSG00000184708" "EIF4ENIF1" "B1AKL2; B1AKL3; B2RBF1; hsa:56478; Q8NCF2; Q9H708; Q9NRA8" "" "Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "2" "0" "1.059" "0.973" "1.112" "1.163" "1.127" "1.077" "1.126" "1.185" "1.108" "743.9" "788.0" "724.1" "826.9" "865.3" "838.1" "801.0" "837.4" "881.6" "824.3" "" "" "" "" "" "" "" "" "" "" "597.5" "568.6" "575.2" "554.0" "598.4" "628.8" "560.8" "611.5" "881.6" "670.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370304273166594920" "False" "High" "IsMasterProtein" "O94906" "Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1" "0.000" "False" "29.577" "9" "8" "8" "8" "941" "106.9" "8.25" "26.18" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06424, Pf13181, Pf14559" "24148" "ENSG00000101161" "PRPF6" "B2RAR5; B3KMC6; hsa:24148; O94906; O95109; Q5VXS5; Q9H3Z1; Q9H4T9; Q9H4U8; Q9NTE6" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "0.975" "1.085" "1.123" "1.005" "1.028" "1.023" "0.995" "0.993" "1.053" "363.3" "354.2" "394.2" "408.1" "365.2" "373.6" "371.7" "361.6" "360.7" "382.5" "" "" "" "" "" "" "" "" "" "" "291.8" "255.5" "313.1" "273.5" "252.6" "280.3" "260.2" "264.1" "360.7" "311.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "469142345215753577" "False" "High" "IsMasterProtein" "Q9Y2R9" "Small ribosomal subunit protein uS7m OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" "0.000" "False" "29.572" "30" "6" "6" "6" "242" "28.1" "9.99" "21.80" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00177" "51081" "ENSG00000125445" "MRPS7" "B2R9N5; hsa:51081; Q53GD6; Q9Y2R9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.942" "1.133" "0.924" "0.921" "0.821" "0.906" "1.085" "1.004" "0.906" "158.0" "148.9" "178.9" "146.0" "145.4" "129.7" "143.1" "171.4" "158.7" "143.2" "" "" "" "" "" "" "" "" "" "" "126.9" "107.4" "142.1" "97.8" "100.6" "97.3" "100.2" "125.2" "158.7" "116.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779708130048871486" "False" "High" "IsMasterProtein" "O43464" "Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2" "0.000" "False" "29.562" "12" "5" "7" "5" "458" "48.8" "10.07" "24.82" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13365, Pf17820" "27429" "ENSG00000115317" "HTRA2" "hsa:27429; O43464; Q9HBZ4; Q9P0Y3; Q9P0Y4" "Mitochondrial protein degradation" "Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity" "6" "0" "0.954" "0.953" "0.959" "1.056" "0.975" "0.952" "0.931" "0.914" "0.985" "494.6" "471.8" "471.4" "474.1" "522.5" "482.0" "471.1" "460.5" "452.0" "487.3" "" "" "" "" "" "" "" "" "" "" "397.3" "340.5" "374.5" "317.7" "361.3" "361.7" "329.8" "336.3" "452.0" "396.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-445851658510322323" "False" "High" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "0.000" "False" "29.562" "46" "5" "7" "5" "128" "14.2" "8.46" "20.95" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "mRNA processing" "4" "0" "1.070" "1.073" "1.034" "1.097" "1.051" "1.114" "1.259" "1.008" "1.059" "514.3" "550.4" "552.1" "531.9" "564.4" "540.7" "572.7" "647.3" "518.2" "544.5" "" "" "" "" "" "" "" "" "" "" "413.1" "397.1" "438.5" "356.4" "390.3" "405.7" "401.0" "472.8" "518.2" "442.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485123881553311665" "False" "High" "IsMasterProtein" "Q8TEB1" "DDB1- and CUL4-associated factor 11 OS=Homo sapiens OX=9606 GN=DCAF11 PE=1 SV=1" "0.000" "False" "29.543" "10" "5" "7" "5" "546" "61.6" "6.40" "26.26" "5" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80344" "ENSG00000100897; ENSG00000284796" "DCAF11" "B3KQ83; D3DS56; hsa:80344; Q5D039; Q86U00; Q86U39; Q8NDN2; Q8TEB1; Q9H2J0; Q9H3A3; Q9H5C9" "Neddylation" "Ciliary landscape" "2" "0" "1.020" "1.039" "1.023" "1.024" "1.026" "0.971" "0.965" "0.997" "1.001" "866.2" "884.0" "900.2" "886.1" "886.8" "888.6" "841.2" "835.6" "863.7" "867.3" "" "" "" "" "" "" "" "" "" "" "695.8" "637.9" "715.0" "593.7" "613.3" "666.7" "589.0" "610.2" "863.7" "705.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3672343249527762985" "False" "High" "IsMasterProtein" "Q9H8M7" "Ubiquitin carboxyl-terminal hydrolase MINDY-3 OS=Homo sapiens OX=9606 GN=MINDY3 PE=1 SV=1" "0.000" "False" "29.540" "13" "5" "8" "5" "445" "49.7" "4.77" "27.03" "5" "protein metabolism;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13898" "80013" "ENSG00000148481" "MINDY3" "Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4; Q9H8M7" "" "" "0" "0" "0.968" "0.940" "1.054" "0.966" "0.917" "0.976" "0.840" "0.888" "0.984" "411.4" "398.1" "386.7" "433.8" "397.5" "377.1" "401.5" "345.7" "365.1" "404.7" "" "" "" "" "" "" "" "" "" "" "330.4" "287.2" "307.2" "290.7" "274.9" "282.9" "281.1" "252.4" "365.1" "329.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5322570357493023656" "False" "High" "IsMasterProtein" "Q8IUQ0" "Clavesin-1 OS=Homo sapiens OX=9606 GN=CLVS1 PE=1 SV=1" "0.000" "False" "29.535" "16" "4" "5" "4" "354" "40.8" "7.20" "20.00" "4" "cell organization and biogenesis" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00650, Pf03765" "157807" "ENSG00000177182" "CLVS1" "B2R7M5; C8UZT3; Q8IUQ0; Q8NB32" "Lysosome Vesicle Biogenesis" "Ectoderm differentiation" "2" "0" "1.166" "0.944" "1.201" "1.142" "1.041" "1.013" "0.993" "1.007" "1.004" "305.9" "356.8" "288.9" "367.3" "349.3" "318.6" "310.0" "303.6" "308.1" "307.1" "" "" "" "" "" "" "" "" "" "" "245.7" "257.5" "229.5" "246.1" "241.6" "239.0" "217.0" "221.7" "308.1" "249.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-493599392499449744" "False" "High" "IsMasterProtein" "P53990" "IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1" "0.000" "False" "29.511" "15" "6" "10" "6" "364" "39.7" "5.35" "32.07" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03398" "9798" "ENSG00000182149" "IST1" "A8KAH5; hsa:9798; J3QLU7; P53990; Q3SYM4; Q9BQ81; Q9BWN2" "Neutrophil degranulation; Sealing of the nuclear envelope (NE) by ESCRT-III" "" "2" "0" "0.972" "0.974" "0.972" "0.922" "0.898" "1.038" "1.081" "1.070" "0.979" "1319.3" "1282.7" "1284.8" "1281.9" "1216.1" "1184.8" "1368.8" "1425.6" "1411.7" "1291.7" "" "" "" "" "" "" "" "" "" "" "1059.7" "925.6" "1020.6" "858.9" "841.1" "888.9" "958.4" "1041.1" "1411.7" "1050.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4235790517375748562" "False" "High" "IsMasterProtein" "O43924" "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1" "0.000" "False" "29.503" "29" "3" "5" "3" "150" "17.4" "5.67" "20.00" "3" "other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf05351" "5147" "ENSG00000156973" "PDE6D" "hsa:5147; O43250; O43924" "ARL13B-mediated ciliary trafficking of INPP5E; RAS processing" "Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "1.051" "1.087" "1.051" "1.015" "1.016" "0.919" "0.933" "1.061" "0.979" "371.5" "390.5" "403.9" "390.5" "377.0" "377.5" "341.2" "346.6" "394.4" "363.7" "" "" "" "" "" "" "" "" "" "" "298.4" "281.8" "320.8" "261.6" "260.7" "283.2" "238.9" "253.1" "394.4" "295.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1632540778200031519" "False" "High" "IsMasterProtein" "Q9BVA0" "Katanin p80 WD40 repeat-containing subunit B1 OS=Homo sapiens OX=9606 GN=KATNB1 PE=1 SV=1" "0.000" "False" "29.468" "13" "6" "6" "6" "655" "72.3" "7.56" "19.94" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf13925" "10300" "ENSG00000140854" "KATNB1" "A6NCG6; hsa:10300; O60620; Q9BVA0" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "0.994" "0.921" "1.034" "0.906" "0.861" "0.879" "0.905" "0.913" "1.004" "294.9" "293.2" "271.7" "304.8" "267.1" "254.0" "259.2" "266.9" "269.3" "296.2" "" "" "" "" "" "" "" "" "" "" "236.8" "211.6" "215.8" "204.2" "184.7" "190.6" "181.5" "195.0" "269.3" "240.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1892947756111346869" "False" "High" "IsMasterProtein" "P42345" "Serine/threonine-protein kinase mTOR OS=Homo sapiens OX=9606 GN=MTOR PE=1 SV=1" "0.000" "False" "29.454" "5" "12" "12" "12" "2549" "288.7" "7.17" "30.79" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08771, Pf11865" "2475" "ENSG00000198793" "MTOR" "hsa:2475; P42345; Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; HSF1-dependent transactivation" "AMP-activated protein kinase signaling; Target of rapamycin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Cardiac hypertrophic response; Extracellular vesicle-mediated signaling in recipient cells; TSLP signaling pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ATM signaling in development and disease ; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; CAMKK2 pathway; Neuroinflammation; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Acute myeloid leukemia; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; Interferon type I signaling pathways; ErbB signaling pathway" "92" "0" "1.076" "1.059" "1.096" "1.141" "1.083" "1.140" "1.032" "1.121" "1.087" "554.4" "596.5" "586.9" "607.6" "632.4" "600.3" "632.1" "572.3" "621.6" "602.5" "" "" "" "" "" "" "" "" "" "" "445.3" "430.4" "466.2" "407.1" "437.4" "450.4" "442.6" "418.0" "621.6" "490.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1941330484708974901" "False" "High" "IsMasterProtein" "P18621" "Large ribosomal subunit protein uL22 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "0.000" "False" "29.449" "28" "5" "14" "4" "184" "21.4" "10.17" "47.32" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.876" "0.994" "0.990" "0.954" "0.945" "0.944" "0.885" "0.887" "0.978" "723.9" "634.2" "719.8" "716.6" "690.6" "684.2" "683.1" "640.6" "642.0" "707.8" "" "" "" "" "" "" "" "" "" "" "581.4" "457.6" "571.7" "480.1" "477.6" "513.3" "478.3" "467.8" "642.0" "575.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2936440106232523244" "False" "High" "IsMasterProtein" "Q9NYH9" "U3 small nucleolar RNA-associated protein 6 homolog OS=Homo sapiens OX=9606 GN=UTP6 PE=1 SV=2" "0.000" "False" "29.410" "11" "6" "9" "5" "597" "70.1" "7.28" "26.80" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08640" "55813" "ENSG00000108651" "UTP6" "hsa:55813; Q8IX96; Q96BL2; Q9NQ91; Q9NYH9" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "NF1 copy number variation syndrome" "3" "0" "1.114" "1.050" "1.297" "1.183" "1.118" "1.095" "1.119" "1.089" "1.031" "432.7" "481.9" "454.2" "561.1" "512.0" "483.8" "474.0" "484.0" "471.3" "446.2" "" "" "" "" "" "" "" "" "" "" "347.5" "347.7" "360.8" "375.9" "354.1" "363.0" "331.9" "353.5" "471.3" "362.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604147819280005923" "False" "High" "IsMasterProtein" "P50613" "Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1" "0.000" "False" "29.380" "16" "5" "9" "5" "346" "39.0" "8.47" "27.88" "5" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1022" "ENSG00000134058; ENSG00000277273" "CDK7" "hsa:1022; P50613; Q9BS60; Q9UE19" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Cardiac hypertrophic response; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "43" "0" "1.037" "0.878" "1.006" "0.982" "0.950" "0.856" "0.962" "1.001" "0.975" "258.4" "268.0" "226.8" "260.0" "253.7" "245.5" "221.2" "248.7" "258.6" "251.8" "" "" "" "" "" "" "" "" "" "" "207.5" "193.4" "180.2" "174.2" "175.5" "184.2" "154.9" "181.6" "258.6" "204.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3880640369393119703" "False" "High" "IsMasterProtein" "Q9H8V3" "Protein ECT2 OS=Homo sapiens OX=9606 GN=ECT2 PE=1 SV=4" "0.000" "False" "29.318" "10" "7" "8" "7" "914" "103.4" "7.71" "24.49" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00533, Pf00621, Pf12738, Pf21242, Pf21243" "1894" "ENSG00000114346" "ECT2" "hsa:1894; Q0MT80; Q2M269; Q6U836; Q9H8V3; Q9NSV8; Q9NVW9" "CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOA GTPase cycle; RHOB GTPase cycle" "Gastric cancer network 1" "7" "0" "1.028" "1.039" "0.931" "1.033" "0.962" "0.879" "1.107" "0.970" "0.993" "238.3" "244.9" "247.6" "221.9" "246.1" "229.2" "209.5" "263.9" "231.1" "236.7" "" "" "" "" "" "" "" "" "" "" "191.4" "176.7" "196.7" "148.7" "170.2" "172.0" "146.7" "192.7" "231.1" "192.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327969175985067622" "False" "High" "IsMasterProtein" "Q6I9Y2" "THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3" "0.000" "False" "29.276" "28" "6" "13" "6" "204" "23.7" "5.67" "44.17" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05615" "80145" "ENSG00000163634" "THOC7" "hsa:80145; Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.078" "1.030" "0.998" "1.042" "1.097" "1.071" "1.065" "1.043" "1.058" "896.2" "966.0" "923.1" "894.3" "933.5" "983.0" "960.1" "954.6" "934.4" "948.4" "" "" "" "" "" "" "" "" "" "" "719.8" "697.1" "733.2" "599.2" "645.6" "737.5" "672.2" "697.2" "934.4" "771.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2264903312611257722" "False" "High" "IsMasterProtein" "Q05469" "Hormone-sensitive lipase OS=Homo sapiens OX=9606 GN=LIPE PE=1 SV=4" "0.000" "False" "29.274" "8" "8" "8" "8" "1076" "116.5" "6.70" "23.21" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf06350, Pf07859" "3991" "ENSG00000079435" "LIPE" "hsa:3991; Q05469; Q3LRT2; Q6NSL7" "Triglyceride catabolism" "AMP-activated protein kinase signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy" "11" "0" "1.098" "0.944" "1.074" "1.118" "1.117" "0.899" "1.089" "1.054" "1.011" "263.2" "289.0" "248.3" "282.6" "294.2" "293.9" "236.7" "286.5" "277.4" "266.1" "" "" "" "" "" "" "" "" "" "" "211.4" "208.5" "197.3" "189.4" "203.5" "220.5" "165.7" "209.2" "277.4" "216.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "983128830238586266" "False" "High" "IsMasterProtein" "Q53F19" "Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2" "0.000" "False" "29.268" "15" "9" "9" "8" "620" "70.5" "5.73" "21.49" "9" "RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10309" "55421" "ENSG00000074356" "NCBP3" "B3KWG7; hsa:55421; Q53F19; Q7L406; Q96FK1; Q9NXZ4" "" "" "0" "0" "1.042" "0.937" "1.082" "1.117" "1.095" "1.100" "1.050" "1.121" "1.025" "376.1" "391.9" "352.4" "407.0" "419.9" "411.9" "413.8" "394.9" "421.7" "385.4" "" "" "" "" "" "" "" "" "" "" "302.1" "282.8" "279.9" "272.7" "290.4" "309.0" "289.7" "288.4" "421.7" "313.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4270729495226616365" "False" "High" "IsMasterProtein" "Q9Y535" "DNA-directed RNA polymerase III subunit RPC8 OS=Homo sapiens OX=9606 GN=POLR3H PE=1 SV=1" "0.000" "False" "29.266" "19" "2" "5" "2" "204" "22.9" "4.58" "19.01" "2" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03876, Pf08292" "171568" "ENSG00000100413" "POLR3H" "B0QYH9; hsa:171568; Q5M7Y8; Q96AE3; Q9BY95; Q9Y535" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; Primary ovarian insufficiency" "11" "0" "0.979" "0.948" "0.947" "1.002" "0.890" "0.974" "0.989" "0.983" "1.034" "264.3" "258.9" "250.5" "250.2" "264.8" "235.3" "257.4" "261.5" "259.8" "273.3" "" "" "" "" "" "" "" "" "" "" "212.3" "186.8" "199.0" "167.6" "183.2" "176.6" "180.2" "190.9" "259.8" "222.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4149430532130191750" "False" "High" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "0.000" "False" "29.261" "14" "7" "11" "7" "564" "62.3" "6.99" "31.31" "7" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Coenzyme A biosynthesis" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "2" "0" "1.005" "1.009" "1.004" "1.018" "1.016" "1.055" "1.015" "0.967" "1.013" "341.2" "342.8" "344.2" "342.4" "347.2" "346.7" "359.8" "346.4" "330.1" "345.8" "" "" "" "" "" "" "" "" "" "" "274.0" "247.3" "273.4" "229.4" "240.1" "260.1" "251.9" "253.0" "330.1" "281.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029277553794243506" "False" "High" "IsMasterProtein" "P61244" "Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1" "0.000" "False" "29.252" "56" "7" "9" "7" "160" "18.3" "6.30" "22.70" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4149" "ENSG00000125952" "MAX" "A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8" "Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation" "11" "0" "0.955" "0.917" "0.978" "0.926" "0.955" "1.005" "0.913" "0.924" "0.955" "255.8" "244.2" "234.6" "250.1" "236.9" "244.4" "257.2" "233.6" "236.5" "244.3" "" "" "" "" "" "" "" "" "" "" "205.5" "176.2" "186.3" "167.6" "163.9" "183.4" "180.1" "170.6" "236.5" "198.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5841636671217917151" "False" "High" "IsMasterProtein" "Q5JTJ3" "Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1" "0.000" "False" "29.218" "38" "4" "7" "4" "125" "14.1" "8.25" "27.30" "4" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf02297" "388753" "ENSG00000168275" "COA6" "hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88" "Mitochondrial protein import" "Mitochondrial complex IV assembly" "2" "0" "1.032" "1.006" "1.060" "1.007" "1.041" "1.012" "1.020" "0.937" "0.975" "814.7" "841.2" "819.4" "863.4" "820.4" "848.0" "824.3" "830.9" "763.6" "794.7" "" "" "" "" "" "" "" "" "" "" "654.4" "607.0" "650.9" "578.4" "567.4" "636.3" "577.2" "606.8" "763.6" "646.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1754415614753477381" "False" "High" "IsMasterProtein" "Q86YV9" "BLOC-2 complex member HPS6 OS=Homo sapiens OX=9606 GN=HPS6 PE=1 SV=1" "0.000" "False" "29.186" "9" "5" "5" "5" "775" "82.9" "6.28" "21.26" "5" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15702, Pf20468" "79803" "ENSG00000166189" "HPS6" "Q5VV69; Q86YV9; Q9H685" "" "" "0" "0" "1.062" "1.073" "1.082" "0.989" "0.917" "0.902" "1.018" "1.038" "1.072" "390.2" "414.5" "418.5" "422.2" "385.9" "357.7" "352.0" "397.2" "405.1" "418.3" "" "" "" "" "" "" "" "" "" "" "313.4" "299.1" "332.5" "282.9" "266.9" "268.4" "246.5" "290.1" "405.1" "340.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-377515032386624778" "False" "High" "IsMasterProtein" "P78346" "Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1" "0.000" "False" "29.156" "22" "5" "6" "5" "268" "29.3" "8.91" "24.80" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01876" "10556" "ENSG00000148688" "RPP30" "B2R799; E9PB02; hsa:10556; P78346" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "0.934" "0.999" "1.053" "1.034" "0.992" "0.960" "0.999" "0.864" "0.995" "573.2" "535.4" "572.9" "603.5" "592.5" "568.5" "550.3" "572.7" "495.2" "570.2" "" "" "" "" "" "" "" "" "" "" "460.4" "386.4" "455.0" "404.3" "409.8" "426.6" "385.3" "418.2" "495.2" "463.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7201160367223049830" "False" "High" "IsMasterProtein" "Cont_Q3MHN5" "Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1" "0.000" "True" "29.133" "17" "8" "8" "8" "474" "53.3" "5.52" "26.25" "8" "transport" "non-structural extracellular;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00273, Pf09164" "530076" "" "GC" "bta:530076; Q3MHN5" "" "" "0" "0" "0.949" "0.776" "1.104" "0.867" "1.057" "1.403" "0.925" "0.951" "0.989" "1114.5" "1057.2" "864.6" "1229.9" "966.2" "1178.2" "1563.4" "1031.3" "1060.4" "1102.0" "" "" "" "" "" "" "" "" "" "" "895.2" "762.9" "686.8" "824.0" "668.2" "884.0" "1094.6" "753.2" "1060.4" "896.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2748783261369810529" "False" "High" "IsMasterProtein" "P11182" "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4" "0.000" "False" "29.132" "13" "6" "8" "6" "482" "53.5" "8.51" "25.68" "6" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.027" "1.012" "0.981" "0.989" "0.995" "0.932" "1.015" "0.999" "1.076" "617.6" "634.4" "624.8" "605.9" "610.9" "614.5" "575.9" "627.1" "617.0" "664.3" "" "" "" "" "" "" "" "" "" "" "496.1" "457.7" "496.3" "406.0" "422.5" "461.1" "403.2" "458.0" "617.0" "540.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2137073451658822686" "False" "High" "IsMasterProtein" "Q01664" "Transcription factor AP-4 OS=Homo sapiens OX=9606 GN=TFAP4 PE=1 SV=2" "0.000" "False" "29.124" "24" "7" "7" "7" "338" "38.7" "5.87" "24.76" "7" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7023" "ENSG00000090447" "TFAP4" "hsa:7023; O60409; Q01664" "" "DYRK1A involvement regarding cell proliferation in brain development" "1" "0" "1.060" "1.046" "0.993" "1.032" "1.035" "0.877" "0.921" "0.957" "1.022" "453.8" "480.8" "474.9" "450.8" "468.3" "469.4" "397.8" "417.9" "434.5" "463.6" "" "" "" "" "" "" "" "" "" "" "364.5" "347.0" "377.2" "302.0" "323.9" "352.2" "278.5" "305.2" "434.5" "377.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5215276665585730267" "False" "High" "IsMasterProtein" "Q9BTD8" "RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1" "0.000" "False" "29.115" "11" "4" "9" "4" "480" "50.4" "9.63" "23.14" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79171" "ENSG00000126254" "RBM42" "hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66" "mRNA Splicing - Major Pathway" "" "1" "0" "1.082" "1.153" "1.180" "1.044" "0.957" "1.018" "1.048" "0.998" "1.021" "294.4" "318.6" "339.5" "347.4" "307.4" "281.8" "299.8" "308.5" "293.9" "300.6" "" "" "" "" "" "" "" "" "" "" "236.5" "229.9" "269.7" "232.8" "212.6" "211.4" "209.9" "225.3" "293.9" "244.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3476317971320699033" "False" "High" "IsMasterProtein" "O43156" "TELO2-interacting protein 1 homolog OS=Homo sapiens OX=9606 GN=TTI1 PE=1 SV=3" "0.000" "False" "29.109" "5" "5" "9" "5" "1089" "122.0" "5.97" "30.84" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf21547" "9675" "ENSG00000101407" "TTI1" "D6W4K3; hsa:9675; O43156; Q5JX67; Q96A38; Q9BR47; Q9H4K0" "" "Fragile X syndrome; Pleural mesothelioma" "2" "0" "1.148" "1.148" "1.145" "1.060" "1.070" "1.188" "1.140" "1.139" "1.119" "489.3" "561.9" "561.9" "560.2" "518.9" "523.6" "581.5" "557.8" "557.3" "547.8" "" "" "" "" "" "" "" "" "" "" "393.0" "405.5" "446.4" "375.3" "358.9" "392.8" "407.1" "407.4" "557.3" "445.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923018383904393967" "False" "High" "IsMasterProtein" "Q8TAP6" "Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1" "0.000" "False" "29.094" "8" "4" "5" "4" "659" "74.4" "6.74" "19.65" "4" "other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15627" "79959" "ENSG00000101624" "CEP76" "B0YJB2; B4DXG5; B4DZW1; hsa:79959; Q658N5; Q8TAP6; Q9H9U7" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Genes related to primary cilium development (based on CRISPR)" "8" "0" "1.022" "0.954" "1.024" "1.055" "0.969" "0.990" "0.925" "1.024" "0.971" "455.7" "465.7" "434.7" "466.5" "480.6" "441.4" "450.9" "421.5" "466.6" "442.6" "" "" "" "" "" "" "" "" "" "" "366.0" "336.0" "345.3" "312.5" "332.4" "331.2" "315.7" "307.8" "466.6" "359.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7653373487496169859" "False" "High" "IsMasterProtein" "Q4VC05" "B-cell CLL/lymphoma 7 protein family member A OS=Homo sapiens OX=9606 GN=BCL7A PE=1 SV=1" "0.000" "False" "29.092" "47" "7" "10" "5" "210" "22.8" "5.14" "25.85" "7" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf04714" "605" "ENSG00000110987" "BCL7A" "B4DJN6; B7ZB21; hsa:605; Q13843; Q14CT7; Q4VC05" "" "" "0" "1" "1.086" "1.072" "1.009" "1.055" "1.075" "0.984" "1.060" "0.974" "0.947" "311.4" "338.3" "333.7" "314.1" "328.6" "334.7" "306.4" "330.0" "303.4" "294.9" "" "" "" "" "" "" "" "" "" "" "250.1" "244.1" "265.1" "210.4" "227.2" "251.2" "214.5" "241.0" "303.4" "239.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914895012756735579" "False" "High" "IsMasterProtein" "P08240" "Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2" "0.000" "False" "29.088" "11" "6" "8" "6" "638" "69.8" "8.95" "25.01" "6" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00448, Pf02881, Pf04086" "6734" "ENSG00000182934" "SRPRA" "A6NIB3; B2R5Z8; B4E0H3; E9PJS4; hsa:6734; P08240; Q9BVJ4" "SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes" "" "2" "0" "1.112" "0.900" "1.027" "1.076" "1.021" "1.096" "1.233" "1.062" "1.086" "658.4" "732.3" "592.6" "676.4" "708.8" "672.0" "721.6" "812.0" "699.1" "715.1" "" "" "" "" "" "" "" "" "" "" "528.8" "528.4" "470.7" "453.2" "490.2" "504.2" "505.2" "593.0" "699.1" "581.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5573566891233996467" "False" "High" "IsMasterProtein" "Q96FV2" "Secernin-2 OS=Homo sapiens OX=9606 GN=SCRN2 PE=1 SV=3" "0.000" "False" "29.073" "16" "5" "11" "5" "425" "46.6" "5.67" "33.06" "5" "protein metabolism" "" "other molecular function" "Pf03577" "90507" "ENSG00000141295" "SCRN2" "A8K3N1; B7Z8S7; E9PBV5; hsa:90507; Q96AC3; Q96FV2; Q9BU04" "" "" "0" "0" "1.143" "1.119" "1.156" "1.188" "1.146" "1.043" "1.027" "1.093" "1.117" "490.9" "561.3" "549.6" "567.5" "583.3" "562.7" "511.9" "503.9" "536.3" "548.6" "" "" "" "" "" "" "" "" "" "" "394.3" "405.0" "436.5" "380.2" "403.4" "422.2" "358.4" "368.0" "536.3" "446.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6677968596851833833" "False" "High" "IsMasterProtein" "Q9NXR8" "Inhibitor of growth protein 3 OS=Homo sapiens OX=9606 GN=ING3 PE=1 SV=2" "0.000" "False" "29.073" "12" "4" "6" "4" "418" "46.7" "6.27" "24.82" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12998" "54556" "ENSG00000071243" "ING3" "A8K790; hsa:54556; O60394; Q567P3; Q6GMT3; Q7Z762; Q969G0; Q96DT4; Q9HC99; Q9NXR8; Q9P081" "HATs acetylate histones" "" "1" "0" "1.057" "0.940" "1.057" "1.011" "1.015" "0.952" "1.035" "1.075" "1.011" "310.8" "328.5" "292.2" "328.5" "314.1" "315.4" "296.0" "321.7" "334.2" "314.2" "" "" "" "" "" "" "" "" "" "" "249.6" "237.1" "232.1" "220.1" "217.3" "236.6" "207.3" "234.9" "334.2" "255.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8811809090486028216" "False" "High" "IsMasterProtein" "Q6QNY0" "Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1" "0.000" "False" "29.062" "32" "5" "5" "5" "202" "21.2" "5.15" "19.59" "5" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cell component" "transporter activity" "Pf15753" "388552" "ENSG00000189114" "BLOC1S3" "B2RXB8; hsa:388552; Q6QNY0" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "1.173" "1.085" "1.175" "1.091" "1.103" "1.052" "0.960" "1.001" "1.059" "407.5" "478.1" "442.2" "478.6" "444.4" "449.6" "428.8" "391.2" "407.9" "431.7" "" "" "" "" "" "" "" "" "" "" "327.3" "345.0" "351.3" "320.7" "307.3" "337.3" "300.2" "285.7" "407.9" "351.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5608231469546375684" "False" "High" "IsMasterProtein" "O00161" "Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1" "0.000" "False" "29.012" "30" "5" "7" "5" "211" "23.3" "5.01" "24.07" "5" "cell-cell signaling;cell organization and biogenesis;stress response;transport" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00835" "8773" "ENSG00000092531" "SNAP23" "hsa:8773; O00161; O00162; Q13602; Q6IAE3" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding" "Insulin signaling" "13" "0" "0.933" "0.849" "1.047" "1.134" "1.237" "1.226" "1.245" "1.275" "1.229" "295.3" "275.5" "250.9" "309.1" "334.8" "365.4" "362.0" "367.6" "376.4" "362.8" "" "" "" "" "" "" "" "" "" "" "237.2" "198.8" "199.3" "207.1" "231.6" "274.2" "253.4" "268.4" "376.4" "295.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1987024820899376297" "False" "High" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "0.000" "False" "29.002" "59" "6" "20" "6" "123" "13.9" "5.52" "52.39" "6" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "0.875" "0.967" "0.872" "0.966" "1.014" "0.914" "0.945" "0.898" "0.964" "1400.7" "1225.9" "1354.2" "1221.8" "1352.9" "1420.4" "1279.8" "1324.0" "1258.4" "1349.7" "" "" "" "" "" "" "" "" "" "" "1125.1" "884.5" "1075.7" "818.6" "935.7" "1065.7" "896.0" "966.9" "1258.4" "1097.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8439683798465219975" "False" "High" "IsMasterProtein" "P08621" "U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2" "0.000" "False" "28.993" "15" "8" "11" "8" "437" "51.5" "9.94" "33.34" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf12220" "6625" "ENSG00000104852" "SNRNP70" "B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.962" "0.955" "1.046" "0.947" "0.959" "0.999" "1.005" "1.055" "1.013" "474.9" "456.7" "453.5" "496.8" "449.8" "455.4" "474.3" "477.4" "501.2" "480.9" "" "" "" "" "" "" "" "" "" "" "381.4" "329.6" "360.2" "332.8" "311.1" "341.7" "332.1" "348.6" "501.2" "391.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2746041825889845794" "False" "High" "IsMasterProtein" "Q15059" "Bromodomain-containing protein 3 OS=Homo sapiens OX=9606 GN=BRD3 PE=1 SV=1" "0.000" "False" "28.991" "9" "6" "10" "2" "726" "79.5" "9.36" "32.81" "6" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00439, Pf17035" "8019" "ENSG00000169925" "BRD3" "B1APD9; hsa:8019; Q15059; Q4G5Y3; Q5T1R7; Q8N5M3; Q92645" "" "" "0" "0" "1.053" "1.250" "1.283" "1.148" "1.099" "1.312" "1.250" "1.043" "1.099" "95.8" "100.8" "119.7" "122.8" "109.9" "105.3" "125.7" "119.7" "99.9" "105.2" "" "" "" "" "" "" "" "" "" "" "76.9" "72.8" "95.1" "82.3" "76.0" "79.0" "88.0" "87.4" "99.9" "85.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-994823259514569156" "False" "High" "IsMasterProtein" "Q96I59" "Asparaginyl-tRNA synthetase OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3" "0.000" "False" "28.967" "16" "7" "8" "7" "477" "54.1" "7.24" "22.29" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "79731" "ENSG00000137513" "NARS2" "G3V178; hsa:79731; Q96I59" "Mitochondrial tRNA aminoacylation" "Ectoderm differentiation" "2" "0" "1.020" "0.888" "0.959" "0.930" "1.080" "1.015" "0.993" "0.920" "0.969" "343.6" "350.3" "305.1" "329.3" "319.7" "371.2" "348.7" "341.1" "315.9" "332.8" "" "" "" "" "" "" "" "" "" "" "275.9" "252.8" "242.3" "220.6" "221.1" "278.5" "244.2" "249.1" "315.9" "270.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847329680640326989" "False" "High" "IsMasterProtein" "Q8NDI1" "EH domain-binding protein 1 OS=Homo sapiens OX=9606 GN=EHBP1 PE=1 SV=3" "0.000" "False" "28.919" "7" "8" "9" "8" "1231" "139.9" "5.35" "27.33" "8" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "23301" "ENSG00000115504" "EHBP1" "hsa:23301; O94977; Q53TG7; Q53TV6; Q580X2; Q6NX72; Q6PIT3; Q6QNV2; Q8NDI1; Q9NWI9" "" "Ciliary landscape" "1" "0" "0.957" "1.007" "0.966" "0.894" "1.002" "1.034" "0.956" "0.982" "0.976" "466.7" "446.6" "469.9" "451.0" "417.0" "467.4" "482.8" "446.2" "458.1" "455.6" "" "" "" "" "" "" "" "" "" "" "374.8" "322.2" "373.3" "302.2" "288.4" "350.7" "338.0" "325.8" "458.1" "370.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8547587141624532923" "False" "High" "IsMasterProtein" "Q9UKV8" "Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3" "0.000" "False" "28.903" "10" "8" "10" "8" "859" "97.1" "9.19" "24.87" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "27161" "ENSG00000123908" "AGO2" "Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8" "MAPK6/MAPK4 signaling; Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; Pre-NOTCH Transcription and Translation; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 Regulates Metabolic Genes; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "24" "0" "1.002" "1.054" "1.130" "1.196" "1.070" "1.179" "1.206" "1.224" "1.097" "430.8" "431.7" "453.8" "487.0" "515.1" "460.8" "507.9" "519.6" "527.3" "472.5" "" "" "" "" "" "" "" "" "" "" "346.0" "311.5" "360.5" "326.3" "356.3" "345.8" "355.6" "379.5" "527.3" "384.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703495334451703375" "False" "High" "IsMasterProtein" "O94782" "Ubiquitin carboxyl-terminal hydrolase 1 OS=Homo sapiens OX=9606 GN=USP1 PE=1 SV=1" "0.000" "False" "28.862" "10" "7" "9" "7" "785" "88.2" "5.45" "29.17" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443" "7398" "ENSG00000162607" "USP1" "A0PJ95; D3DQ57; hsa:7398; O94782; Q05BX7; Q59H66; Q9UFR0; Q9UNJ3" "Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex" "miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network" "4" "0" "1.025" "1.020" "1.103" "0.894" "0.938" "0.970" "0.977" "1.067" "1.023" "835.1" "855.9" "851.9" "921.5" "746.4" "783.6" "810.3" "816.2" "891.1" "854.3" "" "" "" "" "" "" "" "" "" "" "670.7" "617.6" "676.7" "617.4" "516.2" "588.0" "567.3" "596.0" "891.1" "694.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980746601808787358" "False" "High" "IsMasterProtein" "Q9P1U1" "Actin-related protein 3B OS=Homo sapiens OX=9606 GN=ACTR3B PE=1 SV=1" "0.000" "False" "28.845" "15" "6" "18" "3" "418" "47.6" "5.88" "46.57" "6" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "57180" "ENSG00000133627" "ACTR3B" "A8MTG1; B4DFW4; hsa:57180; Q7Z526; Q96BT2; Q9P1U1" "" "" "0" "0" "1.049" "1.043" "1.172" "1.018" "1.026" "1.012" "1.060" "1.079" "1.019" "99.0" "103.8" "103.2" "115.9" "100.7" "101.5" "100.2" "104.8" "106.7" "100.9" "" "" "" "" "" "" "" "" "" "" "79.5" "74.9" "82.0" "77.7" "69.7" "76.1" "70.1" "76.6" "106.7" "82.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3836342718594531018" "False" "High" "IsMasterProtein" "O94921" "Cyclin-dependent kinase 14 OS=Homo sapiens OX=9606 GN=CDK14 PE=1 SV=3" "0.000" "False" "28.845" "18" "8" "11" "7" "469" "53.0" "8.92" "35.44" "8" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5218" "ENSG00000058091" "CDK14" "A4D1E6; A6NK51; A8WFP6; B4DHG5; B4DNM2; hsa:5218; O94921; Q75N06; Q75N22; Q8N764; Q9H3D7; Q9UDR0" "" "" "0" "0" "1.001" "1.039" "1.027" "1.043" "1.016" "0.973" "1.065" "1.037" "1.041" "403.0" "403.4" "418.7" "414.0" "420.4" "409.2" "391.9" "429.2" "417.8" "419.4" "" "" "" "" "" "" "" "" "" "" "323.7" "291.1" "332.6" "277.4" "290.8" "307.0" "274.4" "313.4" "417.8" "341.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5083710564544014092" "False" "High" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "0.000" "False" "28.783" "33" "6" "21" "5" "164" "19.3" "11.65" "55.29" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "6" "0" "1.081" "1.135" "1.061" "1.103" "1.169" "1.013" "1.105" "1.058" "1.091" "965.0" "1043.4" "1095.1" "1024.0" "1064.9" "1128.6" "978.1" "1066.6" "1021.4" "1053.1" "" "" "" "" "" "" "" "" "" "" "775.1" "752.9" "869.8" "686.0" "736.5" "846.8" "684.8" "779.0" "1021.4" "856.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8898508644132712333" "False" "High" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "0.000" "False" "28.766" "28" "7" "13" "7" "221" "25.5" "11.85" "36.63" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "0" "1.056" "1.070" "1.038" "1.066" "1.101" "1.043" "1.081" "1.075" "1.112" "531.8" "561.6" "568.9" "552.1" "566.8" "585.6" "554.5" "575.1" "571.4" "591.2" "" "" "" "" "" "" "" "" "" "" "427.1" "405.3" "451.9" "369.9" "392.0" "439.4" "388.3" "420.0" "571.4" "480.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7069334460136082352" "False" "High" "IsMasterProtein" "Q9Y4P8" "WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens OX=9606 GN=WIPI2 PE=1 SV=1" "0.000" "False" "28.754" "19" "8" "10" "8" "454" "49.4" "6.46" "27.69" "8" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf21032" "26100" "ENSG00000157954" "WIPI2" "B3KNC2; hsa:26100; Q5MNZ8; Q6FI96; Q75L50; Q96IE4; Q9Y364; Q9Y4P8" "Macroautophagy" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "6" "0" "0.944" "0.978" "0.956" "0.890" "0.956" "0.881" "0.864" "0.898" "0.985" "686.5" "648.3" "671.7" "656.4" "610.9" "656.3" "604.7" "593.1" "616.7" "676.5" "" "" "" "" "" "" "" "" "" "" "551.4" "467.8" "533.5" "439.8" "422.5" "492.4" "423.4" "433.1" "616.7" "550.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2858860997982508935" "False" "High" "IsMasterProtein" "Q99757" "Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2" "0.000" "False" "28.750" "31" "3" "9" "3" "166" "18.4" "8.29" "34.13" "3" "stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00085" "25828" "ENSG00000100348" "TXN2" "hsa:25828; Q5JZA0; Q6FH60; Q99757; Q9UH29" "Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine" "Oxidative stress response" "3" "0" "0.997" "0.998" "0.894" "0.891" "0.930" "0.937" "0.936" "0.923" "0.918" "1047.3" "1044.5" "1045.4" "935.9" "933.6" "973.5" "980.9" "980.1" "966.7" "961.3" "" "" "" "" "" "" "" "" "" "" "841.2" "753.6" "830.4" "627.1" "645.7" "730.4" "686.8" "715.8" "966.7" "781.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276103228213200498" "False" "High" "IsMasterProtein" "P62308" "Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1" "0.000" "False" "28.730" "34" "3" "15" "3" "76" "8.5" "8.88" "42.37" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6637" "ENSG00000143977" "SNRPG" "D6W5G6; hsa:6637; P62308; Q15357; Q6IB86" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.019" "1.082" "1.081" "1.025" "1.078" "1.035" "0.953" "0.990" "1.000" "997.0" "1016.1" "1078.9" "1078.0" "1021.5" "1074.3" "1031.9" "950.3" "986.7" "996.9" "" "" "" "" "" "" "" "" "" "" "800.8" "733.2" "857.0" "722.2" "706.5" "806.1" "722.5" "694.0" "986.7" "810.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5661386699023188299" "False" "High" "IsMasterProtein" "Q9Y4B4" "Helicase ARIP4 OS=Homo sapiens OX=9606 GN=RAD54L2 PE=1 SV=4" "0.000" "False" "28.726" "4" "4" "5" "4" "1467" "162.7" "6.09" "21.04" "4" "cell organization and biogenesis" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "23132" "ENSG00000164080" "RAD54L2" "hsa:23132; Q8TB57; Q9BV54; Q9Y4B4" "" "DYRK1A involvement regarding cell proliferation in brain development" "1" "0" "1.037" "0.973" "1.148" "1.079" "0.979" "1.100" "1.156" "1.058" "1.024" "256.1" "265.6" "249.0" "294.0" "276.2" "250.7" "281.7" "295.9" "271.0" "262.3" "" "" "" "" "" "" "" "" "" "" "205.7" "191.6" "197.8" "197.0" "191.0" "188.1" "197.2" "216.1" "271.0" "213.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8809739148280005605" "False" "High" "IsMasterProtein" "P46776" "Large ribosomal subunit protein uL15 OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "0.000" "False" "28.705" "34" "5" "10" "5" "148" "16.6" "11.00" "34.27" "5" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "0.995" "1.057" "1.092" "1.075" "0.957" "1.102" "1.037" "1.064" "1.097" "568.9" "566.3" "601.6" "621.1" "611.8" "544.5" "626.8" "589.8" "605.1" "623.9" "" "" "" "" "" "" "" "" "" "" "457.0" "408.6" "477.9" "416.2" "423.1" "408.6" "438.8" "430.7" "605.1" "507.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869827592286108947" "False" "High" "IsMasterProtein" "Q9UPQ9" "Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4" "0.000" "False" "28.678" "4" "5" "6" "5" "1833" "193.9" "6.76" "21.54" "5" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10427, Pf16608" "23112" "ENSG00000100354" "TNRC6B" "B0QY73; B0QY78; B4DGC0; hsa:23112; Q5TH52; Q8TBX2; Q9UPQ9" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "" "18" "0" "0.972" "1.079" "1.225" "1.113" "1.077" "1.237" "1.235" "1.186" "1.114" "176.5" "171.5" "190.5" "216.2" "196.4" "190.1" "218.3" "218.1" "209.3" "196.6" "" "" "" "" "" "" "" "" "" "" "141.8" "123.8" "151.3" "144.9" "135.9" "142.6" "152.8" "159.3" "209.3" "159.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4459716120349710015" "False" "High" "IsMasterProtein" "O14545" "TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1" "0.000" "False" "28.665" "13" "7" "7" "7" "582" "64.8" "5.29" "18.19" "7" "other biological processes" "mitochondrion" "other molecular function" "Pf21366" "10906" "ENSG00000135148" "TRAFD1" "A8K5L6; B4DI89; hsa:10906; O14545" "" "" "0" "0" "0.996" "0.979" "1.094" "1.019" "0.951" "1.091" "1.002" "0.951" "1.027" "326.2" "325.0" "319.3" "356.9" "332.4" "310.2" "356.0" "326.9" "310.3" "335.0" "" "" "" "" "" "" "" "" "" "" "262.0" "234.5" "253.7" "239.2" "229.9" "232.8" "249.3" "238.7" "310.3" "272.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225000128541682863" "False" "High" "IsMasterProtein" "Q99836" "Myeloid differentiation primary response protein MyD88 OS=Homo sapiens OX=9606 GN=MYD88 PE=1 SV=1" "0.000" "False" "28.660" "25" "6" "7" "6" "296" "33.2" "6.15" "23.32" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf13676" "4615" "ENSG00000172936" "MYD88" "B4DKH8; B4DKU4; B4DQ60; B4DQ72; hsa:4615; J3KPU4; J3KQ87; J3KQJ6; P78397; Q53XS7; Q99836" "PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; ER-Phagosome pathway; Interleukin-1 signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; MyD88 deficiency (TLR5); IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; IL1 and megakaryocytes in obesity; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; MYD88 distinct input-output pathway; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; HDAC6 interactions in the central nervous system; Toll-like receptor signaling pathway" "35" "0" "1.054" "0.908" "0.926" "0.995" "0.933" "0.857" "0.961" "1.096" "0.976" "282.1" "297.3" "256.3" "261.2" "280.6" "263.2" "241.8" "271.1" "309.2" "275.4" "" "" "" "" "" "" "" "" "" "" "226.6" "214.5" "203.6" "175.0" "194.1" "197.5" "169.3" "198.0" "309.2" "224.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548984541792378367" "False" "High" "IsMasterProtein" "Q9Y5Y2" "Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1" "0.000" "False" "28.639" "13" "3" "5" "3" "271" "28.8" "5.83" "21.68" "3" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "10101" "ENSG00000095906" "NUBP2" "D3DU80; hsa:10101; Q9NWB2; Q9Y5Y2" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis" "2" "0" "1.063" "1.051" "1.036" "1.121" "0.974" "1.029" "1.009" "1.051" "1.059" "440.5" "468.1" "462.9" "456.1" "493.8" "429.0" "453.1" "444.5" "463.0" "466.5" "" "" "" "" "" "" "" "" "" "" "353.8" "337.8" "367.7" "305.6" "341.5" "321.8" "317.2" "324.6" "463.0" "379.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "394232053154577892" "False" "High" "IsMasterProtein" "Q92530" "Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2" "0.000" "False" "28.628" "21" "5" "8" "5" "271" "29.8" "5.74" "23.61" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf08577, Pf11566" "9491" "ENSG00000125818" "PSMF1" "A0AVQ9; D3DVW3; hsa:9491; Q92530; Q9H4I1" "UCH proteinases; Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "" "59" "0" "0.987" "0.964" "1.070" "1.005" "1.000" "1.027" "1.044" "1.066" "1.084" "800.3" "789.8" "771.6" "856.3" "804.5" "800.3" "821.9" "835.9" "853.0" "867.7" "" "" "" "" "" "" "" "" "" "" "642.8" "569.9" "612.9" "573.7" "556.4" "600.5" "575.5" "610.5" "853.0" "705.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3796638279955905475" "False" "High" "IsMasterProtein" "Q9NZ32" "Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1" "0.000" "False" "28.618" "16" "5" "5" "5" "417" "46.3" "7.37" "18.25" "5" "transport" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "" "Pf00022" "55860" "ENSG00000131966" "ACTR10" "hsa:55860; Q9H9Y5; Q9NWY2; Q9NZ32" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "" "5" "0" "0.950" "0.970" "0.926" "0.947" "0.907" "0.964" "0.970" "0.962" "0.979" "595.2" "565.4" "577.5" "551.5" "563.7" "539.7" "573.9" "577.6" "572.5" "582.8" "" "" "" "" "" "" "" "" "" "" "478.1" "407.9" "458.7" "369.5" "389.9" "404.9" "401.8" "421.9" "572.5" "474.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4637087941136759499" "False" "High" "IsMasterProtein" "O15126" "Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2" "0.000" "False" "28.554" "24" "6" "11" "6" "338" "37.9" "7.42" "31.05" "6" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "9522" "ENSG00000085365" "SCAMP1" "hsa:9522; O15126; O43587; Q6FG23; Q96BX1; Q96QK5" "Neutrophil degranulation" "" "1" "0" "0.931" "0.979" "0.958" "0.969" "0.991" "0.929" "0.865" "0.949" "0.963" "593.3" "552.2" "580.8" "568.2" "575.1" "588.1" "551.1" "513.3" "562.8" "571.3" "" "" "" "" "" "" "" "" "" "" "476.5" "398.4" "461.3" "380.7" "397.7" "441.3" "385.9" "374.9" "562.8" "464.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "743572851164951841" "False" "High" "IsMasterProtein" "Q13472" "DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1" "0.000" "False" "28.546" "9" "8" "8" "7" "1001" "112.3" "8.34" "23.37" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01396, Pf01751, Pf06839" "7156" "ENSG00000177302; ENSG00000284238" "TOP3A" "A8KA61; B4DK80; D3DXC7; hsa:7156; Q13472; Q13473" "HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; Impaired BRCA2 binding to RAD51" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "16" "0" "0.921" "0.918" "0.964" "0.901" "0.933" "0.971" "0.980" "0.977" "1.034" "386.3" "355.7" "354.4" "372.4" "348.0" "360.6" "375.0" "378.6" "377.4" "399.4" "" "" "" "" "" "" "" "" "" "" "310.3" "256.7" "281.5" "249.5" "240.7" "270.5" "262.5" "276.5" "377.4" "324.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263352969811880337" "False" "High" "IsMasterProtein" "Q13432" "Protein unc-119 homolog A OS=Homo sapiens OX=9606 GN=UNC119 PE=1 SV=1" "0.000" "False" "28.537" "35" "8" "10" "7" "240" "26.9" "6.42" "25.37" "8" "cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05351" "9094" "ENSG00000109103" "UNC119" "A8K8G4; F1T095; hsa:9094; O95126; Q13432" "" "Joubert syndrome; Ciliopathies" "2" "0" "0.948" "0.973" "1.005" "0.968" "0.950" "1.015" "0.938" "1.034" "1.032" "548.0" "519.5" "533.2" "550.4" "530.3" "520.8" "556.3" "513.8" "566.4" "565.4" "" "" "" "" "" "" "" "" "" "" "440.1" "374.9" "423.5" "368.8" "366.8" "390.7" "389.5" "375.2" "566.4" "459.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4100918330742864628" "False" "High" "IsMasterProtein" "Q96GK7" "Oxaloacetate tautomerase FAHD2A, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1" "0.000" "False" "28.536" "21" "6" "7" "6" "314" "34.6" "8.24" "23.68" "6" "" "" "other molecular function" "Pf01557" "51011" "ENSG00000115042; ENSG00000292086" "FAHD2A" "hsa:51011; Q96GK7; Q9Y3B0" "" "" "0" "0" "0.906" "0.922" "0.924" "0.912" "0.971" "0.961" "0.934" "0.878" "0.936" "452.9" "410.3" "417.6" "418.5" "413.1" "439.8" "435.2" "423.2" "397.8" "424.1" "" "" "" "" "" "" "" "" "" "" "363.8" "296.1" "331.7" "280.4" "285.7" "329.9" "304.7" "309.1" "397.8" "344.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2054594351010378030" "False" "High" "IsMasterProtein" "Q9H977" "WD repeat-containing protein 54 OS=Homo sapiens OX=9606 GN=WDR54 PE=1 SV=1" "0.000" "False" "28.534" "17" "3" "3" "3" "334" "35.9" "6.20" "15.60" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf21031" "84058" "ENSG00000005448" "WDR54" "B9A049; D6W5I3; hsa:84058; Q53H85; Q86V45; Q9H977" "" "" "0" "0" "1.005" "0.992" "1.042" "1.076" "1.036" "0.987" "0.970" "0.925" "1.033" "240.9" "242.0" "238.8" "250.8" "259.1" "249.4" "237.6" "233.7" "222.9" "248.7" "" "" "" "" "" "" "" "" "" "" "193.5" "174.6" "189.7" "168.1" "179.2" "187.1" "166.4" "170.6" "222.9" "202.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1025854285268432181" "False" "High" "IsMasterProtein" "P56377" "AP-1 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP1S2 PE=1 SV=1" "0.000" "False" "28.479" "26" "4" "6" "3" "157" "18.6" "5.47" "22.73" "4" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "8905" "ENSG00000182287" "AP1S2" "B4DSU4; hsa:8905; O95326; P56377; Q9H2N6" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "0" "1.020" "1.108" "0.968" "0.927" "1.056" "0.966" "0.995" "0.966" "0.972" "376.4" "384.0" "417.2" "364.5" "349.0" "397.5" "363.5" "374.5" "363.5" "365.8" "" "" "" "" "" "" "" "" "" "" "302.3" "277.1" "331.4" "244.2" "241.4" "298.2" "254.5" "273.5" "363.5" "297.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864018122010782004" "False" "High" "IsMasterProtein" "P35080" "Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3" "0.000" "False" "28.456" "20" "2" "5" "2" "140" "15.0" "6.99" "15.85" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5217" "ENSG00000070087" "PFN2" "B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2" "RHO GTPases Activate Formins; Signaling by ROBO receptors" "Physico-chemical features and toxicity-associated pathways" "3" "0" "1.055" "0.975" "0.984" "0.999" "1.142" "0.986" "1.015" "1.026" "0.994" "491.4" "518.5" "479.2" "483.7" "490.8" "561.2" "484.5" "498.9" "504.3" "488.6" "" "" "" "" "" "" "" "" "" "" "394.7" "374.1" "380.7" "324.1" "339.4" "421.0" "339.2" "364.4" "504.3" "397.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559199072785365377" "False" "High" "IsMasterProtein" "Q14493" "Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1" "0.000" "False" "28.447" "27" "6" "13" "6" "270" "31.3" "7.47" "34.63" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15247" "7884" "ENSG00000163950" "SLBP" "B3KRJ5; hsa:7884; Q14493" "RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA" "8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "5" "0" "1.020" "1.000" "1.016" "1.008" "0.971" "1.156" "1.305" "1.338" "1.102" "346.7" "353.7" "346.7" "352.2" "349.3" "336.7" "400.7" "452.4" "464.0" "382.1" "" "" "" "" "" "" "" "" "" "" "278.5" "255.2" "275.4" "236.0" "241.6" "252.6" "280.5" "330.4" "464.0" "310.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4335544546222164902" "False" "High" "IsMasterProtein" "Q9NRX4" "14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1" "0.000" "False" "28.443" "49" "7" "14" "7" "125" "13.8" "6.07" "27.72" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05005" "29085" "ENSG00000054148" "PHPT1" "B1AMX0; B1AMX1; hsa:29085; Q9H0Y3; Q9NRX4" "" "" "0" "0" "0.955" "0.902" "0.950" "1.044" "0.967" "1.363" "0.967" "0.980" "1.025" "644.6" "615.4" "581.2" "612.6" "673.2" "623.1" "878.6" "623.4" "631.8" "660.9" "" "" "" "" "" "" "" "" "" "" "517.7" "444.0" "461.7" "410.4" "465.6" "467.5" "615.1" "455.3" "631.8" "537.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6327174108011486304" "False" "High" "IsMasterProtein" "Q96CX6" "Leucine-rich repeat-containing protein 58 OS=Homo sapiens OX=9606 GN=LRRC58 PE=1 SV=2" "0.000" "False" "28.412" "17" "6" "11" "6" "371" "40.6" "6.84" "29.45" "6" "signal transduction" "" "" "Pf00560, Pf12799" "116064" "ENSG00000163428" "LRRC58" "hsa:116064; Q96CX6" "" "" "0" "0" "1.078" "0.891" "1.090" "0.949" "0.998" "1.002" "0.892" "0.984" "1.045" "275.3" "296.8" "245.3" "300.1" "261.1" "274.8" "275.9" "245.6" "270.8" "287.6" "" "" "" "" "" "" "" "" "" "" "221.1" "214.2" "194.8" "201.1" "180.6" "206.2" "193.2" "179.4" "270.8" "233.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2647028449518715682" "False" "High" "IsMasterProtein" "P16383" "Intron Large complex component GCFC2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2" "0.000" "False" "28.402" "12" "9" "10" "9" "781" "89.3" "5.99" "25.72" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf07842" "6936" "ENSG00000005436" "GCFC2" "A4UHQ8; A4UHQ9; hsa:6936; O95032; P16383; Q53TY0; Q6P2F2" "mRNA Splicing - Major Pathway" "" "1" "0" "1.060" "0.980" "1.071" "1.082" "1.007" "1.014" "1.021" "0.991" "1.036" "427.4" "452.8" "418.9" "457.9" "462.5" "430.2" "433.4" "436.3" "423.6" "442.8" "" "" "" "" "" "" "" "" "" "" "343.3" "326.7" "332.8" "306.8" "319.9" "322.8" "303.4" "318.7" "423.6" "360.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6240337966017765757" "False" "High" "IsMasterProtein" "Q0VDG4" "Secernin-3 OS=Homo sapiens OX=9606 GN=SCRN3 PE=1 SV=1" "0.000" "False" "28.375" "17" "5" "5" "5" "424" "48.5" "5.55" "19.00" "5" "protein metabolism" "" "other molecular function" "Pf03577" "79634" "ENSG00000144306" "SCRN3" "B4DI11; C9JPC1; D3DPE0; hsa:79634; Q0VDG4; Q7L1C5; Q9H5R5" "" "" "0" "0" "0.976" "0.825" "1.050" "1.006" "0.883" "0.968" "0.917" "0.863" "1.010" "176.4" "172.2" "145.5" "185.4" "177.6" "155.7" "170.7" "161.9" "152.3" "178.3" "" "" "" "" "" "" "" "" "" "" "141.7" "124.2" "115.6" "124.2" "122.8" "116.9" "119.5" "118.2" "152.3" "145.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3098042065705187363" "False" "High" "IsMasterProtein" "Q6IBW4" "Condensin-2 complex subunit H2 OS=Homo sapiens OX=9606 GN=NCAPH2 PE=1 SV=1" "0.000" "False" "28.356" "12" "7" "8" "7" "605" "68.2" "4.74" "24.78" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06278, Pf16858, Pf16869" "29781" "ENSG00000025770" "NCAPH2" "B7WPH1; hsa:29781; O43788; Q13391; Q6IBW4; Q96C14; Q96GJ0; Q9BQ71; Q9BUT3; Q9BVD1" "Condensation of Prophase Chromosomes" "IL-18 signaling pathway" "2" "0" "1.040" "0.985" "1.135" "1.138" "1.005" "1.150" "1.192" "1.205" "1.090" "608.1" "632.6" "599.2" "690.4" "692.3" "611.3" "699.5" "725.0" "732.5" "662.8" "" "" "" "" "" "" "" "" "" "" "488.4" "456.4" "475.9" "462.6" "478.8" "458.7" "489.8" "529.5" "732.5" "539.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-101820050033511890" "False" "High" "IsMasterProtein" "Q14966" "Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2" "0.000" "False" "28.354" "5" "9" "10" "9" "1978" "220.5" "6.38" "22.21" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12171" "27332" "ENSG00000075292" "ZNF638" "A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37" "Transcriptional regulation of white adipocyte differentiation" "" "1" "0" "0.892" "0.956" "1.031" "0.976" "1.030" "0.915" "0.906" "0.886" "0.934" "228.3" "203.8" "218.3" "235.3" "223.0" "235.2" "209.0" "206.9" "202.2" "213.2" "" "" "" "" "" "" "" "" "" "" "183.4" "147.0" "173.4" "157.7" "154.2" "176.5" "146.3" "151.1" "202.2" "173.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945924760519134314" "False" "High" "IsMasterProtein" "Q9H9C1" "Spermatogenesis-defective protein 39 homolog OS=Homo sapiens OX=9606 GN=VIPAS39 PE=1 SV=1" "0.000" "False" "28.331" "16" "7" "8" "7" "493" "57.0" "7.40" "27.54" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04840" "63894" "ENSG00000151445" "VIPAS39" "B4DPI6; hsa:63894; O95434; Q9H7E1; Q9H9C1; Q9H9I9" "" "" "0" "0" "1.046" "1.045" "1.152" "1.094" "1.053" "1.055" "1.082" "1.028" "1.061" "221.9" "232.0" "231.8" "255.6" "242.7" "233.7" "234.2" "240.2" "228.0" "235.3" "" "" "" "" "" "" "" "" "" "" "178.2" "167.4" "184.2" "171.2" "167.8" "175.3" "164.0" "175.4" "228.0" "191.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3324031393637842436" "False" "High" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "0.000" "False" "28.256" "50" "5" "21" "5" "86" "10.1" "7.97" "48.45" "5" "other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "1.080" "1.105" "1.034" "0.964" "1.033" "1.000" "1.001" "0.963" "0.998" "1484.1" "1603.0" "1640.3" "1535.1" "1430.2" "1533.1" "1483.5" "1485.9" "1428.5" "1481.2" "" "" "" "" "" "" "" "" "" "" "1192.0" "1156.7" "1303.0" "1028.5" "989.1" "1150.2" "1038.7" "1085.2" "1428.5" "1204.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7779362395337591117" "False" "High" "IsMasterProtein" "Q96FX7" "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1" "0.000" "False" "28.243" "31" "6" "9" "6" "289" "31.4" "7.36" "31.23" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08704" "115708" "ENSG00000166166" "TRMT61A" "A6NN78; hsa:115708; Q8N7Q9; Q96FX7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.942" "1.083" "1.024" "1.060" "0.951" "1.062" "0.932" "0.924" "1.059" "438.5" "412.9" "475.0" "449.2" "464.7" "416.9" "465.7" "408.5" "405.0" "464.5" "" "" "" "" "" "" "" "" "" "" "352.2" "297.9" "377.3" "301.0" "321.4" "312.8" "326.0" "298.4" "405.0" "377.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479231618500312272" "False" "High" "IsMasterProtein" "Q8NF91" "Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4" "0.000" "False" "28.220" "1" "8" "8" "7" "8797" "1010.5" "5.53" "24.42" "8" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23345" "ENSG00000131018" "SYNE1" "B3W695; E7EQI5; H0Y4C0; O94890; Q3ZCV0; Q5JV19; Q5JV22; Q8N9P7; Q8NF91; Q8TCP1; Q8WWW6; Q8WWW7; Q8WXF6; Q96N17; Q9C0A7; Q9H525; Q9H526; Q9NS36; Q9NU50; Q9UJ06; Q9UJ07; Q9ULF8" "Meiotic synapsis" "Envelope proteins and their potential roles in EDMD physiopathology" "2" "0" "0.944" "0.934" "0.964" "0.987" "0.957" "0.989" "0.944" "0.947" "0.963" "477.8" "451.0" "446.4" "460.8" "471.7" "457.4" "472.7" "451.1" "452.4" "460.1" "" "" "" "" "" "" "" "" "" "" "383.8" "325.4" "354.6" "308.7" "326.2" "343.2" "330.9" "329.4" "452.4" "374.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6438294564185077030" "False" "High" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "0.000" "False" "28.218" "21" "6" "8" "5" "284" "33.3" "9.31" "28.35" "6" "other biological processes" "plasma membrane;other membranes;mitochondrion" "" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "1" "1.005" "1.032" "0.967" "0.992" "1.048" "0.960" "0.996" "0.938" "1.067" "727.9" "731.3" "751.4" "704.1" "721.8" "763.1" "698.7" "724.8" "682.5" "776.9" "" "" "" "" "" "" "" "" "" "" "584.6" "527.7" "596.8" "471.8" "499.2" "572.6" "489.2" "529.3" "682.5" "631.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6043879365308815932" "False" "High" "IsMasterProtein" "O75818" "Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3" "0.000" "False" "28.206" "18" "5" "6" "5" "363" "41.8" "6.67" "27.14" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08584" "10799" "ENSG00000124787" "RPP40" "hsa:10799; O75818; Q5VX97; Q8WVK8" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "0.973" "1.001" "1.006" "0.946" "1.007" "0.956" "0.967" "0.860" "0.941" "549.0" "534.3" "549.8" "552.4" "519.2" "552.9" "524.8" "530.9" "472.4" "516.9" "" "" "" "" "" "" "" "" "" "" "441.0" "385.5" "436.7" "370.1" "359.1" "414.8" "367.4" "387.7" "472.4" "420.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1395564513229487982" "False" "High" "IsMasterProtein" "O94826" "Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1" "0.000" "False" "28.203" "13" "9" "11" "9" "608" "67.4" "7.12" "34.88" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00515, Pf13181" "9868" "ENSG00000154174" "TOMM70" "D3DN48; hsa:9868; O94826" "Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Mitochondrial protein import; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; PINK1-PRKN Mediated Mitophagy" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "9" "0" "0.971" "0.909" "1.002" "1.007" "1.013" "0.942" "1.020" "1.088" "1.009" "787.0" "764.2" "715.3" "788.5" "792.2" "797.4" "741.3" "803.0" "856.0" "794.2" "" "" "" "" "" "" "" "" "" "" "632.1" "551.4" "568.2" "528.3" "547.9" "598.3" "519.0" "586.4" "856.0" "645.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "672780113730382771" "False" "High" "IsMasterProtein" "Q99952" "Tyrosine-protein phosphatase non-receptor type 18 OS=Homo sapiens OX=9606 GN=PTPN18 PE=1 SV=2" "0.000" "False" "28.201" "15" "4" "6" "4" "460" "50.5" "8.25" "18.50" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26469" "ENSG00000072135" "PTPN18" "B4E1E6; hsa:26469; Q53P42; Q99952" "Downregulation of ERBB2 signaling; Interleukin-37 signaling" "B cell receptor signaling pathway" "3" "0" "0.675" "0.329" "0.467" "0.848" "0.963" "1.247" "0.737" "0.480" "0.691" "163.7" "110.4" "53.8" "76.5" "138.8" "157.5" "204.2" "120.7" "78.6" "113.1" "" "" "" "" "" "" "" "" "" "" "131.5" "79.7" "42.7" "51.3" "96.0" "118.2" "143.0" "88.1" "78.6" "92.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-536665306058471520" "False" "High" "IsMasterProtein" "Q07020" "Large ribosomal subunit protein eL18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "0.000" "False" "28.200" "22" "4" "8" "4" "188" "21.6" "11.72" "30.33" "4" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.896" "1.161" "1.124" "1.105" "1.058" "1.055" "0.879" "0.986" "1.082" "444.5" "398.4" "516.2" "499.6" "491.3" "470.4" "468.9" "390.9" "438.3" "481.1" "" "" "" "" "" "" "" "" "" "" "357.0" "287.4" "410.0" "334.7" "339.8" "352.9" "328.3" "285.5" "438.3" "391.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-867231523467416798" "False" "High" "IsMasterProtein" "Q6K0P9" "Pyrin and HIN domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYHIN1 PE=1 SV=1" "0.000" "False" "28.194" "10" "4" "13" "1" "492" "55.0" "9.80" "33.51" "4" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "149628" "ENSG00000163564" "PYHIN1" "hsa:149628; Q5T3W6; Q6K0P6; Q6K0P7; Q6K0P8; Q6K0P9; Q8WW65" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8134550695814129755" "False" "High" "IsMasterProtein" "P30519" "Heme oxygenase 2 OS=Homo sapiens OX=9606 GN=HMOX2 PE=1 SV=2" "0.000" "False" "28.175" "21" "4" "5" "4" "316" "36.0" "5.41" "17.26" "4" "other metabolic processes;stress response" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf01126" "3163" "ENSG00000103415; ENSG00000277424" "HMOX2" "A8MT35; D3DUD5; hsa:3163; I3L430; O60605; P30519" "RHOA GTPase cycle; Neutrophil degranulation; Cytoprotection by HMOX1; Iron uptake and transport; Heme degradation" "" "5" "0" "0.981" "0.971" "1.030" "0.972" "1.022" "0.964" "1.024" "1.031" "0.913" "298.2" "292.7" "289.6" "307.0" "289.8" "304.8" "287.4" "305.3" "307.3" "272.3" "" "" "" "" "" "" "" "" "" "" "239.5" "211.2" "230.0" "205.7" "200.4" "228.7" "201.2" "222.9" "307.3" "221.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5017693853216972141" "False" "High" "IsMasterProtein" "Q969S3" "Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "0.000" "False" "28.171" "14" "6" "9" "6" "477" "54.2" "6.15" "24.12" "6" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "0.811" "0.859" "1.081" "1.129" "1.226" "1.446" "1.296" "1.165" "1.087" "178.3" "144.6" "153.1" "192.8" "201.4" "218.7" "258.0" "231.2" "207.7" "193.9" "" "" "" "" "" "" "" "" "" "" "143.2" "104.4" "121.6" "129.2" "139.3" "164.1" "180.6" "168.8" "207.7" "157.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8706245126759521959" "False" "High" "IsMasterProtein" "Q9BRP4" "Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2" "0.000" "False" "28.131" "18" "7" "7" "7" "392" "42.2" "6.32" "22.44" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80227" "ENSG00000175575" "PAAF1" "A6NDR5; B4DPB0; B7ZAS9; hsa:80227; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9BRP4; Q9HAB6" "" "" "0" "0" "0.990" "1.020" "1.048" "1.102" "1.094" "0.995" "1.041" "0.999" "1.041" "687.6" "680.5" "701.0" "720.3" "757.9" "752.2" "684.3" "715.6" "686.9" "715.7" "" "" "" "" "" "" "" "" "" "" "552.3" "491.0" "556.8" "482.6" "524.1" "564.4" "479.1" "522.6" "686.9" "582.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4643888973216991338" "False" "High" "IsMasterProtein" "Q9Y4F3" "Meiosis regulator and mRNA stability factor 1 OS=Homo sapiens OX=9606 GN=MARF1 PE=1 SV=6" "0.000" "False" "28.128" "4" "7" "7" "7" "1742" "192.7" "7.87" "22.85" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf01936, Pf11608, Pf12872, Pf19687" "9665" "ENSG00000166783; ENSG00000277140" "MARF1" "A8MSK2; B2RNX2; B4DYY9; B7ZMG1; B7ZMG2; F8VV09; hsa:9665; Q6P1R6; Q8WYR2; Q9Y4F3; Q9Y4J9" "" "" "0" "0" "0.935" "0.959" "1.027" "0.952" "0.903" "0.989" "0.919" "0.962" "1.001" "267.6" "250.1" "256.6" "274.9" "254.8" "241.5" "264.6" "245.9" "257.4" "267.7" "" "" "" "" "" "" "" "" "" "" "214.9" "180.5" "203.8" "184.2" "176.2" "181.2" "185.3" "179.6" "257.4" "217.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7969959000989021007" "False" "High" "IsMasterProtein" "P38935" "DNA-binding protein SMUBP-2 OS=Homo sapiens OX=9606 GN=IGHMBP2 PE=1 SV=3" "0.000" "False" "28.127" "7" "8" "8" "8" "993" "109.1" "8.97" "23.82" "8" "cell organization and biogenesis;RNA metabolism OR transcription" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01424, Pf01428, Pf13086, Pf13087, Pf21138" "3508" "ENSG00000132740" "IGHMBP2" "A0PJD2; hsa:3508; P38935; Q00443; Q14177" "" "" "0" "0" "1.075" "1.043" "1.229" "1.218" "1.061" "1.214" "1.152" "1.186" "1.138" "563.5" "605.5" "587.7" "692.5" "686.3" "597.7" "683.9" "649.3" "668.4" "641.1" "" "" "" "" "" "" "" "" "" "" "452.6" "436.9" "466.8" "464.0" "474.6" "448.4" "478.9" "474.2" "668.4" "521.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3889272514054364250" "False" "High" "IsMasterProtein" "O15541" "E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1" "0.000" "False" "28.111" "17" "5" "7" "5" "343" "38.8" "5.69" "20.60" "5" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00642, Pf13920" "7737" "ENSG00000125352" "RNF113A" "B2RBR7; hsa:7737; O15541" "mRNA Splicing - Major Pathway" "" "1" "0" "1.011" "1.116" "1.111" "1.021" "1.042" "1.036" "1.068" "1.073" "1.007" "531.0" "536.9" "592.5" "589.8" "542.1" "553.3" "549.9" "567.2" "569.5" "534.7" "" "" "" "" "" "" "" "" "" "" "426.5" "387.4" "470.6" "395.2" "374.9" "415.1" "385.0" "414.2" "569.5" "434.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6678202250508335411" "False" "High" "IsMasterProtein" "Q96CS2" "HAUS augmin-like complex subunit 1 OS=Homo sapiens OX=9606 GN=HAUS1 PE=1 SV=1" "0.000" "False" "28.111" "26" "6" "7" "6" "278" "31.8" "5.53" "22.31" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "" "115106" "ENSG00000152240" "HAUS1" "B2RDM7; hsa:115106; Q8N837; Q96CS2" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.055" "1.078" "1.046" "1.124" "1.156" "1.088" "1.140" "1.173" "1.163" "500.9" "528.6" "540.0" "524.2" "563.2" "579.1" "545.2" "571.2" "587.5" "582.7" "" "" "" "" "" "" "" "" "" "" "402.3" "381.4" "428.9" "351.2" "389.5" "434.5" "381.7" "417.1" "587.5" "473.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818907558764607522" "False" "High" "IsMasterProtein" "Q8IWD4" "Coiled-coil domain-containing protein 117 OS=Homo sapiens OX=9606 GN=CCDC117 PE=1 SV=1" "0.000" "False" "28.089" "19" "5" "6" "5" "279" "30.5" "5.07" "26.62" "5" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf15810" "150275" "ENSG00000159873" "CCDC117" "A8K0F1; B7Z2V1; B7Z860; hsa:150275; Q6ICA7; Q8IWD4; Q8N278" "" "" "0" "0" "1.051" "1.024" "0.975" "0.968" "1.072" "0.987" "1.049" "1.024" "1.030" "616.8" "648.1" "631.8" "601.3" "597.3" "661.0" "608.5" "647.0" "631.6" "635.5" "" "" "" "" "" "" "" "" "" "" "495.4" "467.6" "501.9" "402.9" "413.1" "495.9" "426.1" "472.5" "631.6" "516.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5702774175857427246" "False" "High" "IsMasterProtein" "Q02078" "Myocyte-specific enhancer factor 2A OS=Homo sapiens OX=9606 GN=MEF2A PE=1 SV=1" "0.000" "False" "28.086" "9" "4" "6" "2" "507" "54.8" "7.91" "19.61" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4205" "ENSG00000068305" "MEF2A" "B4DFQ7; F6XG23; hsa:4205; O43814; Q02078; Q14223; Q14224; Q59GX4; Q7Z6C9; Q96D14" "Myogenesis; ERK/MAPK targets" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; TGF-beta signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; 2q37 copy number variation syndrome" "13" "0" "1.146" "1.064" "1.110" "0.873" "0.981" "1.035" "0.963" "0.994" "0.947" "57.5" "66.0" "61.2" "63.9" "50.2" "56.4" "59.5" "55.4" "57.2" "54.5" "" "" "" "" "" "" "" "" "" "" "46.2" "47.6" "48.6" "42.8" "34.7" "42.3" "41.7" "40.5" "57.2" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3661455698439909776" "False" "High" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "0.000" "False" "28.073" "15" "4" "5" "4" "307" "34.9" "9.57" "17.38" "4" "signal transduction" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.018" "0.855" "0.963" "0.839" "0.946" "1.012" "0.931" "0.940" "0.961" "233.1" "237.3" "199.2" "224.6" "195.6" "220.4" "235.9" "217.1" "219.0" "224.0" "" "" "" "" "" "" "" "" "" "" "187.2" "171.2" "158.2" "150.5" "135.3" "165.4" "165.2" "158.5" "219.0" "182.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5097662091813912850" "False" "High" "IsMasterProtein" "Q02252" "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Homo sapiens OX=9606 GN=ALDH6A1 PE=1 SV=2" "0.000" "False" "28.069" "13" "7" "7" "7" "535" "57.8" "8.50" "21.30" "7" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf00171" "4329" "ENSG00000119711" "ALDH6A1" "B2R609; B4DFS8; hsa:4329; J3KNU8; Q02252; Q9UKM8" "Branched-chain amino acid catabolism" "" "1" "0" "0.962" "0.961" "0.932" "1.010" "0.942" "0.916" "0.921" "0.933" "0.956" "777.0" "747.4" "746.7" "724.5" "784.7" "731.8" "712.0" "715.3" "724.8" "742.8" "" "" "" "" "" "" "" "" "" "" "624.1" "539.3" "593.1" "485.4" "542.7" "549.0" "498.5" "522.4" "724.8" "604.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631999146533429965" "False" "High" "IsMasterProtein" "Q02878" "Large ribosomal subunit protein eL6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "0.000" "False" "28.054" "24" "8" "11" "8" "288" "32.7" "10.58" "34.99" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.099" "1.280" "1.175" "1.047" "1.089" "1.052" "0.946" "1.066" "1.143" "497.8" "547.1" "637.4" "584.8" "521.2" "542.2" "523.5" "471.1" "530.5" "569.1" "" "" "" "" "" "" "" "" "" "" "399.9" "394.8" "506.3" "391.8" "360.5" "406.8" "366.5" "344.0" "530.5" "462.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2326963864063357056" "False" "High" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "0.000" "False" "28.053" "7" "5" "8" "5" "739" "83.3" "6.70" "22.59" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "4p16.3 copy number variation" "3" "0" "1.213" "1.031" "1.193" "1.146" "1.158" "1.233" "1.207" "1.269" "1.146" "676.0" "820.3" "696.8" "806.8" "774.4" "783.1" "833.8" "816.1" "857.9" "774.7" "" "" "" "" "" "" "" "" "" "" "543.0" "591.9" "553.5" "540.6" "535.6" "587.6" "583.7" "596.0" "857.9" "630.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-986396495116814729" "False" "High" "IsMasterProtein" "Q8IZ69" "tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens OX=9606 GN=TRMT2A PE=1 SV=2" "0.000" "False" "28.043" "11" "7" "7" "7" "625" "68.7" "7.94" "20.15" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf05958" "27037" "ENSG00000099899" "TRMT2A" "D3DX25; hsa:27037; Q32P57; Q8IZ69; Q96ME6; Q9H732" "" "22q11.2 copy number variation syndrome" "1" "0" "1.037" "1.095" "1.150" "1.267" "1.170" "1.165" "1.221" "1.315" "1.145" "192.3" "199.3" "210.6" "221.1" "243.6" "224.9" "223.9" "234.8" "252.8" "220.2" "" "" "" "" "" "" "" "" "" "" "154.4" "143.8" "167.3" "148.2" "168.5" "168.7" "156.8" "171.5" "252.8" "179.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-116543853618974429" "False" "High" "IsMasterProtein" "P20338" "Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3" "0.000" "False" "28.007" "26" "5" "9" "2" "218" "24.4" "6.07" "31.29" "5" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5867" "ENSG00000168118" "RAB4A" "hsa:5867; P20338; Q5T7P7; Q9BQ44" "RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane; TBC/RABGAPs; MET receptor recycling" "VEGFA-VEGFR2 signaling; Insulin signaling; Intracellular trafficking proteins involved in CMT neuropathy; 16p11.2 distal deletion syndrome" "9" "0" "1.051" "0.951" "1.140" "1.091" "1.005" "1.000" "1.027" "1.146" "1.057" "285.8" "300.3" "271.7" "325.9" "311.9" "287.2" "285.9" "293.6" "327.6" "302.0" "" "" "" "" "" "" "" "" "" "" "229.5" "216.7" "215.8" "218.4" "215.7" "215.5" "200.2" "214.4" "327.6" "245.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8892747589052197154" "False" "High" "IsMasterProtein" "Q5W0B1" "ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1" "0.000" "False" "27.979" "9" "6" "7" "6" "726" "81.1" "5.72" "23.34" "6" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13923" "79596" "ENSG00000152193" "OBI1" "B2RN99; hsa:79596; Q5W0B1; Q8TBY2; Q9H0T2; Q9H8M0" "" "" "0" "0" "1.015" "1.009" "1.038" "1.058" "1.025" "0.942" "1.013" "1.023" "1.008" "533.7" "541.6" "538.3" "553.7" "564.8" "547.2" "502.6" "540.7" "546.0" "537.8" "" "" "" "" "" "" "" "" "" "" "428.7" "390.8" "427.6" "371.0" "390.7" "410.5" "351.9" "394.9" "546.0" "437.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1080022240978719765" "False" "High" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "0.000" "False" "27.971" "28" "7" "14" "7" "201" "22.8" "7.02" "36.08" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.946" "1.050" "0.932" "0.911" "0.991" "0.938" "0.927" "0.982" "0.912" "2057.2" "1945.2" "2159.7" "1918.3" "1874.0" "2038.2" "1929.0" "1908.0" "2019.3" "1875.7" "" "" "" "" "" "" "" "" "" "" "1652.3" "1403.6" "1715.5" "1285.2" "1296.1" "1529.3" "1350.6" "1393.4" "2019.3" "1525.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869717489525171844" "False" "High" "IsMasterProtein" "O60306" "RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4" "0.000" "False" "27.943" "9" "10" "11" "10" "1485" "171.2" "6.37" "26.49" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf16399, Pf21143, Pf21144" "9716" "ENSG00000021776" "AQR" "A0JP17; A5YKK3; hsa:9716; O60306; Q2YDX9; Q6IRU8; Q6PIC8" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "5" "0" "0.962" "0.920" "0.911" "1.022" "0.961" "0.988" "0.963" "0.975" "1.049" "460.5" "443.2" "423.5" "419.6" "470.6" "442.5" "455.1" "443.5" "448.9" "483.3" "" "" "" "" "" "" "" "" "" "" "369.9" "319.8" "336.4" "281.1" "325.5" "332.0" "318.6" "323.9" "448.9" "393.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1378614036355870767" "False" "High" "IsMasterProtein" "Q9UIV1" "CCR4-NOT transcription complex subunit 7 OS=Homo sapiens OX=9606 GN=CNOT7 PE=1 SV=3" "0.000" "False" "27.935" "13" "3" "5" "3" "285" "32.7" "4.84" "21.37" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857" "29883" "ENSG00000198791" "CNOT7" "A8MZM5; B3KMP1; B3KN35; D3DSP6; G3V108; hsa:29883; Q7Z530; Q9UIV1" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "1.079" "0.966" "1.003" "0.990" "0.933" "0.899" "0.934" "0.950" "0.998" "610.3" "658.7" "589.7" "611.9" "604.0" "569.6" "548.9" "570.1" "579.8" "609.3" "" "" "" "" "" "" "" "" "" "" "490.2" "475.3" "468.4" "410.0" "417.8" "427.4" "384.3" "416.3" "579.8" "495.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5267554590826270529" "False" "High" "IsMasterProtein" "P62380" "TATA box-binding protein-like 1 OS=Homo sapiens OX=9606 GN=TBPL1 PE=1 SV=1" "0.000" "False" "27.877" "30" "4" "6" "4" "186" "20.9" "9.54" "21.79" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "9519" "ENSG00000028839" "TBPL1" "A8K8F5; hsa:9519; O95753; P62380; Q9BWD5; Q9Z2Z0" "" "" "0" "0" "0.933" "0.994" "0.956" "1.056" "1.095" "1.050" "1.065" "0.932" "1.025" "347.7" "324.5" "345.6" "332.4" "367.1" "380.7" "365.2" "370.3" "324.0" "356.3" "" "" "" "" "" "" "" "" "" "" "279.3" "234.2" "274.5" "222.7" "253.9" "285.7" "255.7" "270.5" "324.0" "289.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654723519218057862" "False" "High" "IsMasterProtein" "Q9BXB5" "Oxysterol-binding protein-related protein 10 OS=Homo sapiens OX=9606 GN=OSBPL10 PE=1 SV=2" "0.000" "False" "27.875" "12" "8" "9" "7" "764" "83.9" "8.31" "28.19" "8" "other metabolic processes;transport" "other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "114884" "ENSG00000144645" "OSBPL10" "B4E212; hsa:114884; Q9BTU5; Q9BXB5" "Acyl chain remodelling of PS" "" "1" "1" "1.033" "0.927" "0.962" "0.875" "0.992" "0.886" "0.887" "0.929" "1.029" "244.5" "252.6" "226.7" "235.2" "213.8" "242.6" "216.7" "216.9" "227.1" "251.6" "" "" "" "" "" "" "" "" "" "" "196.4" "182.3" "180.1" "157.6" "147.9" "182.0" "151.7" "158.4" "227.1" "204.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8964751153975728348" "False" "High" "IsMasterProtein" "Q96RE7" "Nucleus accumbens-associated protein 1 OS=Homo sapiens OX=9606 GN=NACC1 PE=1 SV=1" "0.000" "False" "27.854" "14" "6" "7" "6" "527" "57.2" "5.74" "22.23" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf10523" "112939" "ENSG00000160877" "NACC1" "hsa:112939; Q96RE7" "" "" "0" "0" "1.009" "1.057" "1.100" "0.986" "1.019" "0.964" "1.064" "1.127" "1.113" "431.0" "434.8" "455.6" "474.1" "425.2" "439.4" "415.4" "458.7" "486.0" "479.5" "" "" "" "" "" "" "" "" "" "" "346.2" "313.7" "361.9" "317.6" "294.1" "329.7" "290.8" "335.0" "486.0" "390.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2107690767117566608" "False" "High" "IsMasterProtein" "P04150" "Glucocorticoid receptor OS=Homo sapiens OX=9606 GN=NR3C1 PE=1 SV=1" "0.000" "False" "27.844" "8" "4" "4" "4" "777" "85.6" "6.38" "16.77" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf02155" "2908" "ENSG00000113580" "NR3C1" "A0ZXF9; B0LPG8; D3DQF4; F5ATB7; hsa:2908; P04150; P04151; Q53EP5; Q6N0A4" "Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression; Regulation of NPAS4 gene transcription" "Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling" "21" "0" "1.111" "1.068" "1.096" "0.991" "1.093" "0.999" "0.996" "1.138" "1.112" "204.9" "227.7" "218.8" "224.6" "203.0" "223.9" "204.8" "204.2" "233.2" "227.8" "" "" "" "" "" "" "" "" "" "" "164.6" "164.3" "173.8" "150.5" "140.4" "168.0" "143.4" "149.1" "233.2" "185.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157020147431294409" "False" "High" "IsMasterProtein" "P17028" "Zinc finger protein 24 OS=Homo sapiens OX=9606 GN=ZNF24 PE=1 SV=4" "0.000" "False" "27.835" "18" "7" "8" "7" "368" "42.1" "6.21" "25.32" "7" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7572" "ENSG00000172466" "ZNF24" "hsa:7572; O14754; P17028; Q53YE4; Q6ICR5; Q8IZN4" "" "" "0" "0" "0.990" "0.992" "0.962" "1.047" "1.052" "0.987" "1.051" "1.044" "1.008" "886.0" "877.1" "879.1" "852.2" "927.6" "932.5" "874.8" "931.1" "925.1" "893.1" "" "" "" "" "" "" "" "" "" "" "711.6" "632.9" "698.3" "571.0" "641.5" "699.6" "612.5" "680.0" "925.1" "726.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174498408520760419" "False" "High" "IsMasterProtein" "Q02241" "Kinesin-like protein KIF23 OS=Homo sapiens OX=9606 GN=KIF23 PE=1 SV=3" "0.000" "False" "27.828" "7" "6" "7" "6" "960" "110.0" "8.51" "17.79" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf16540" "9493" "ENSG00000137807" "KIF23" "B4E1K0; hsa:9493; Q02241; Q8WVP0" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Mitotic Telophase/Cytokinesis" "Pleural mesothelioma" "5" "0" "0.994" "1.043" "0.954" "0.843" "0.918" "0.877" "1.009" "1.051" "0.989" "267.4" "265.8" "278.9" "255.1" "225.3" "245.6" "234.6" "269.8" "281.1" "264.4" "" "" "" "" "" "" "" "" "" "" "214.8" "191.8" "221.5" "170.9" "155.8" "184.2" "164.2" "197.0" "281.1" "215.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4782042828393349132" "False" "High" "IsMasterProtein" "P52756" "RNA-binding protein 5 OS=Homo sapiens OX=9606 GN=RBM5 PE=1 SV=2" "0.000" "False" "27.828" "6" "5" "6" "3" "815" "92.1" "6.28" "23.53" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "10181" "ENSG00000003756" "RBM5" "B2RA45; B4DM16; B4DMF9; B4DZ63; hsa:10181; P52756; Q93021; Q9BU14; Q9HDA6; Q9UKY8; Q9UL24" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.001" "1.164" "1.181" "1.065" "1.027" "1.083" "1.061" "1.067" "1.082" "346.9" "347.3" "403.8" "409.8" "369.5" "356.3" "375.7" "368.2" "370.2" "375.2" "" "" "" "" "" "" "" "" "" "" "278.6" "250.6" "320.7" "274.6" "255.6" "267.3" "263.0" "268.9" "370.2" "305.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660198099631122457" "False" "High" "IsMasterProtein" "Q7Z3B3" "KAT8 regulatory NSL complex subunit 1 OS=Homo sapiens OX=9606 GN=KANSL1 PE=1 SV=3" "0.000" "False" "27.817" "6" "6" "7" "6" "1105" "120.9" "8.75" "24.52" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275" "284058" "ENSG00000120071" "KANSL1" "A8K5E4; B3KT49; hsa:284058; I3L4J3; Q6AW85; Q7Z3B3; Q8IYH1; Q9BRH0; Q9NTE7; Q9UFT0; Q9ULF3" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "Pathways affected in adenoid cystic carcinoma" "3" "0" "1.014" "0.953" "1.173" "1.117" "1.091" "1.062" "1.079" "1.130" "1.088" "240.9" "244.4" "229.5" "282.6" "269.0" "262.9" "255.9" "259.9" "272.2" "262.0" "" "" "" "" "" "" "" "" "" "" "193.5" "176.3" "182.3" "189.4" "186.0" "197.2" "179.2" "189.8" "272.2" "213.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8609206004865475892" "False" "High" "IsMasterProtein" "Q96BD8" "Spindle and kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=SKA1 PE=1 SV=1" "0.000" "False" "27.813" "26" "8" "9" "8" "255" "29.5" "7.12" "25.73" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf07160" "220134" "ENSG00000154839; ENSG00000262634" "SKA1" "B2R9Y6; B4E0P4; hsa:220134; Q96BD8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.006" "0.975" "0.992" "0.950" "0.996" "0.978" "1.080" "1.044" "1.030" "604.9" "608.4" "589.8" "600.2" "574.4" "602.5" "591.4" "653.5" "631.3" "623.1" "" "" "" "" "" "" "" "" "" "" "485.8" "439.0" "468.5" "402.2" "397.3" "452.0" "414.1" "477.3" "631.3" "506.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4426217636715391666" "False" "High" "IsMasterProtein" "Q9H9F9" "Actin-related protein 5 OS=Homo sapiens OX=9606 GN=ACTR5 PE=1 SV=2" "0.000" "False" "27.728" "12" "6" "6" "6" "607" "68.3" "5.27" "19.03" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00022" "79913" "ENSG00000101442" "ACTR5" "hsa:79913; Q86WF7; Q8IUY5; Q8N724; Q9BRN0; Q9BVB7; Q9H9F9" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "0.956" "0.838" "1.226" "1.198" "0.928" "0.837" "1.001" "1.061" "1.126" "71.2" "68.0" "59.6" "87.3" "85.3" "66.1" "59.6" "71.2" "75.5" "80.2" "" "" "" "" "" "" "" "" "" "" "57.2" "49.1" "47.4" "58.5" "59.0" "49.6" "41.7" "52.0" "75.5" "65.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2819715853452011200" "False" "High" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "0.000" "False" "27.727" "45" "6" "10" "6" "166" "19.2" "7.34" "34.33" "6" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "mRNA Splicing - Major Pathway" "" "1" "0" "1.129" "1.111" "1.122" "0.996" "1.066" "1.010" "0.949" "0.987" "1.014" "699.6" "789.8" "777.7" "785.0" "696.7" "745.6" "706.5" "663.8" "690.5" "709.8" "" "" "" "" "" "" "" "" "" "" "561.9" "569.9" "617.7" "525.9" "481.9" "559.4" "494.6" "484.8" "690.5" "577.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4255545335258343942" "False" "High" "IsMasterProtein" "Q9Y253" "DNA polymerase eta OS=Homo sapiens OX=9606 GN=POLH PE=1 SV=1" "0.000" "False" "27.714" "9" "5" "6" "5" "713" "78.4" "8.44" "21.02" "5" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00817, Pf11799, Pf18439, Pf21704" "5429" "ENSG00000170734" "POLH" "hsa:5429; Q7L8E3; Q96BC4; Q9BX13; Q9Y253" "HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Translesion Synthesis by POLH" "DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum" "6" "0" "1.019" "1.061" "1.003" "1.050" "1.136" "0.961" "1.011" "0.993" "1.074" "316.9" "323.0" "336.1" "317.8" "332.6" "359.9" "304.5" "320.5" "314.5" "340.5" "" "" "" "" "" "" "" "" "" "" "254.5" "233.0" "267.0" "212.9" "230.0" "270.0" "213.2" "234.1" "314.5" "276.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-750359377190588192" "False" "High" "IsMasterProtein" "O75616" "GTPase Era, mitochondrial OS=Homo sapiens OX=9606 GN=ERAL1 PE=1 SV=2" "0.000" "False" "27.710" "15" "5" "6" "5" "437" "48.3" "8.84" "16.61" "5" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "translation activity;nucleic acid binding activity;other molecular function" "Pf01926" "26284" "ENSG00000132591" "ERAL1" "B3KN21; C9JEC6; hsa:26284; O75616; O75617; Q8WUY4; Q96LE2; Q96TC0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Primary ovarian insufficiency" "4" "0" "1.119" "1.026" "1.141" "1.018" "1.065" "0.981" "1.137" "1.113" "0.974" "128.3" "143.6" "131.7" "146.4" "130.6" "136.7" "125.8" "145.9" "142.7" "125.0" "" "" "" "" "" "" "" "" "" "" "103.0" "103.6" "104.6" "98.1" "90.3" "102.5" "88.1" "106.5" "142.7" "101.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7634397569492690707" "False" "High" "IsMasterProtein" "Q96HY7" "2-oxoadipate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2" "0.000" "False" "27.695" "7" "7" "9" "7" "919" "103.0" "6.93" "30.59" "7" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00676, Pf02779, Pf16870" "55526" "ENSG00000181192" "DHTKD1" "hsa:55526; Q68CU5; Q96HY7; Q9BUM8; Q9HCE2" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "1.067" "1.024" "1.036" "1.054" "1.062" "0.979" "0.989" "1.006" "1.015" "908.3" "968.9" "929.9" "940.9" "957.7" "964.7" "888.9" "898.2" "913.8" "921.9" "" "" "" "" "" "" "" "" "" "" "729.5" "699.1" "738.6" "630.4" "662.3" "723.8" "622.4" "655.9" "913.8" "749.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "968979890096343817" "False" "High" "IsMasterProtein" "P53611" "Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2" "0.000" "False" "27.683" "21" "6" "7" "6" "331" "36.9" "5.03" "18.83" "6" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00432" "5876" "ENSG00000137955" "RABGGTB" "hsa:5876; P53611; Q92697" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "" "2" "0" "0.965" "0.978" "0.922" "1.019" "0.912" "0.837" "0.992" "0.934" "0.952" "521.1" "502.7" "509.8" "480.4" "530.8" "475.0" "435.9" "516.8" "486.7" "496.1" "" "" "" "" "" "" "" "" "" "" "418.5" "362.8" "404.9" "321.9" "367.1" "356.4" "305.2" "377.5" "486.7" "403.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2783720911668015522" "False" "High" "IsMasterProtein" "Q9NWT6" "Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2" "0.000" "False" "27.642" "21" "5" "5" "5" "349" "40.3" "5.57" "19.85" "5" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13621" "55662" "ENSG00000166135" "HIF1AN" "D3DR69; hsa:55662; Q5W147; Q969Q7; Q9NPV5; Q9NWT6" "Cellular response to hypoxia" "MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling" "3" "0" "0.901" "1.021" "0.972" "1.068" "0.964" "0.905" "0.924" "0.962" "0.973" "700.7" "631.4" "715.5" "681.5" "748.4" "675.3" "634.4" "647.4" "673.9" "681.6" "" "" "" "" "" "" "" "" "" "" "562.8" "455.6" "568.3" "456.6" "517.6" "506.7" "444.2" "472.8" "673.9" "554.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6374027858147592096" "False" "High" "IsMasterProtein" "O95613" "Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4" "0.000" "False" "27.640" "3" "9" "10" "9" "3336" "377.8" "5.55" "27.15" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton" "other molecular function" "Pf10495" "5116" "ENSG00000160299" "PCNT" "hsa:5116; O43152; O95613; Q7Z7C9" "Aggrephagy; Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy" "" "10" "0" "0.956" "1.044" "1.049" "1.062" "1.078" "0.935" "0.925" "1.005" "1.051" "122.3" "116.9" "127.7" "128.2" "129.8" "131.8" "114.3" "113.1" "123.0" "128.5" "" "" "" "" "" "" "" "" "" "" "98.2" "84.3" "101.4" "85.9" "89.8" "98.9" "80.1" "82.6" "123.0" "104.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3248682762130005719" "False" "High" "IsMasterProtein" "Q9BQ39" "ATP-dependent RNA helicase DDX50 OS=Homo sapiens OX=9606 GN=DDX50 PE=1 SV=1" "0.000" "False" "27.624" "6" "4" "6" "2" "737" "82.5" "9.17" "24.52" "4" "" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf00270, Pf00271, Pf08152" "79009" "ENSG00000107625" "DDX50" "hsa:79009; Q5VX37; Q8WV76; Q9BQ39; Q9BWI8" "" "" "0" "0" "0.906" "0.860" "0.998" "0.891" "0.922" "0.835" "0.856" "0.763" "0.906" "208.2" "188.6" "179.1" "207.8" "185.5" "192.0" "173.8" "178.1" "158.9" "188.5" "" "" "" "" "" "" "" "" "" "" "167.2" "136.1" "142.2" "139.2" "128.3" "144.0" "121.7" "130.1" "158.9" "153.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "984760743341076196" "False" "High" "IsMasterProtein" "Q9Y547" "Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=IFT25 PE=1 SV=1" "0.000" "False" "27.584" "40" "3" "6" "3" "144" "16.3" "5.03" "26.02" "3" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00754" "51668" "ENSG00000081870" "IFT25" "A6NG57; D3DQ45; hsa:51668; Q9Y547; Q9Y684" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis; Alstrom syndrome" "6" "0" "0.974" "0.991" "0.950" "0.817" "0.843" "0.933" "0.846" "0.884" "0.874" "392.1" "382.0" "388.7" "372.4" "320.3" "330.7" "365.7" "331.7" "346.8" "342.7" "" "" "" "" "" "" "" "" "" "" "315.0" "275.6" "308.8" "249.5" "221.5" "248.1" "256.0" "242.2" "346.8" "278.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5139072581549819915" "False" "High" "IsMasterProtein" "Q8IWV8" "E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens OX=9606 GN=UBR2 PE=1 SV=1" "0.000" "False" "27.572" "4" "8" "8" "8" "1755" "200.4" "6.24" "25.04" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02207, Pf02617, Pf18995" "23304" "ENSG00000024048" "UBR2" "O15057; Q4VXK2; Q5TFH6; Q6P2I2; Q6ZUD0; Q8IWV8" "Antigen processing: Ubiquitination & Proteasome degradation" "Male infertility; Primary ovarian insufficiency" "3" "0" "0.979" "0.918" "0.955" "0.979" "0.960" "0.869" "0.913" "0.930" "0.952" "615.0" "602.3" "564.4" "587.4" "601.8" "590.5" "534.6" "561.2" "572.2" "585.5" "" "" "" "" "" "" "" "" "" "" "494.0" "434.6" "448.4" "393.6" "416.2" "443.1" "374.3" "409.9" "572.2" "476.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-344337871911847900" "False" "High" "IsMasterProtein" "Q86X53" "Glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ERICH1 PE=1 SV=1" "0.000" "False" "27.560" "15" "5" "5" "5" "443" "49.0" "4.78" "14.85" "5" "" "" "" "" "157697" "ENSG00000104714" "ERICH1" "A8K2J9; hsa:157697; Q86X53; Q9P063" "" "" "0" "0" "1.074" "1.117" "1.017" "1.055" "1.039" "0.953" "0.929" "1.060" "1.008" "189.5" "203.6" "211.7" "192.8" "199.8" "196.9" "180.5" "176.0" "200.8" "191.0" "" "" "" "" "" "" "" "" "" "" "152.2" "146.9" "168.1" "129.2" "138.2" "147.7" "126.4" "128.6" "200.8" "155.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6036677964263745223" "False" "High" "IsMasterProtein" "Q8NFH4" "Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1" "0.000" "False" "27.549" "19" "6" "8" "6" "326" "36.7" "5.92" "26.99" "6" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "79023" "ENSG00000075188" "NUP37" "hsa:79023; Q8NFH4; Q9H644" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "1.000" "1.027" "1.004" "1.007" "1.038" "0.905" "0.929" "0.913" "1.004" "845.8" "845.6" "868.5" "848.8" "852.0" "878.3" "765.0" "785.5" "771.9" "848.9" "" "" "" "" "" "" "" "" "" "" "679.3" "610.2" "689.9" "568.7" "589.2" "659.0" "535.6" "573.7" "771.9" "690.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659552786150411994" "False" "High" "IsMasterProtein" "O75127" "Pentatricopeptide repeat-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD1 PE=1 SV=2" "0.000" "False" "27.511" "8" "6" "7" "6" "700" "78.8" "8.59" "26.73" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf01535" "26024" "ENSG00000106246" "PTCD1" "hsa:26024; O75127; Q3ZB78; Q66K60; Q9UDV2" "" "" "0" "0" "1.113" "1.070" "1.076" "1.141" "1.103" "1.107" "1.167" "1.166" "1.086" "713.2" "794.1" "763.0" "767.5" "814.0" "786.9" "789.3" "832.2" "831.5" "774.7" "" "" "" "" "" "" "" "" "" "" "572.8" "573.0" "606.1" "514.2" "563.0" "590.4" "552.7" "607.8" "831.5" "630.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4618404774181820652" "False" "High" "IsMasterProtein" "P57076" "Cilia- and flagella-associated protein 298 OS=Homo sapiens OX=9606 GN=CFAP298 PE=1 SV=1" "0.000" "False" "27.460" "14" "3" "9" "3" "290" "33.2" "7.44" "28.33" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf11069" "56683" "ENSG00000159079" "CFAP298" "hsa:56683; P57076; Q53FH0" "" "Ciliopathies" "1" "0" "1.021" "0.950" "0.926" "0.866" "0.889" "0.813" "0.842" "0.900" "0.887" "564.3" "576.3" "536.2" "522.7" "488.7" "501.8" "458.9" "475.0" "508.0" "500.2" "" "" "" "" "" "" "" "" "" "" "453.2" "415.8" "425.9" "350.2" "338.0" "376.5" "321.3" "346.9" "508.0" "406.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4633912985078584352" "False" "High" "IsMasterProtein" "P07948" "Tyrosine-protein kinase Lyn OS=Homo sapiens OX=9606 GN=LYN PE=1 SV=3" "0.000" "False" "27.456" "19" "9" "11" "6" "512" "58.5" "7.11" "32.98" "9" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "4067" "ENSG00000254087" "LYN" "A0AVQ5; hsa:4067; P07948" "CD209 (DC-SIGN) signaling; FCGR activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Regulation of signaling by CBL; EPHB-mediated forward signaling; GPVI-mediated activation cascade; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Cyclin D associated events in G1; Regulation of KIT signaling; Growth hormone receptor signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Platelet Adhesion to exposed collagen; CD28 co-stimulation; Dectin-2 family; PECAM1 interactions; CTLA4 inhibitory signaling" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; GDNF signaling" "45" "1" "1.018" "0.877" "0.975" "1.052" "0.930" "1.221" "1.087" "1.067" "0.979" "591.8" "602.5" "518.9" "576.9" "622.6" "550.3" "722.4" "643.2" "631.4" "579.3" "" "" "" "" "" "" "" "" "" "" "475.4" "434.7" "412.2" "386.5" "430.6" "412.9" "505.8" "469.7" "631.4" "471.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4655855300014543961" "False" "High" "IsMasterProtein" "Q06330" "Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3" "0.000" "False" "27.455" "15" "6" "9" "6" "500" "55.6" "7.18" "25.54" "6" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09270, Pf09271, Pf20144" "3516" "ENSG00000168214" "RBPJ" "B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Formation of paraxial mesoderm; Somitogenesis; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; Notch signaling pathway" "20" "0" "0.982" "0.991" "1.024" "1.103" "1.005" "0.980" "1.000" "1.027" "0.974" "707.5" "694.9" "701.0" "724.6" "780.3" "711.1" "693.5" "707.9" "726.8" "688.9" "" "" "" "" "" "" "" "" "" "" "568.3" "501.4" "556.8" "485.5" "539.6" "533.5" "485.5" "516.9" "726.8" "560.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-383335111069342987" "False" "High" "IsMasterProtein" "Q6PD74" "Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1" "0.000" "False" "27.438" "14" "3" "4" "3" "315" "34.6" "4.64" "17.39" "3" "transport" "cytosol;nucleus;other cell component" "" "Pf10199" "79719" "ENSG00000103591" "AAGAB" "B4DG44; hsa:79719; Q6FI86; Q6PD74; Q7Z5X9; Q9H0P1; Q9HAK0" "" "" "0" "0" "1.020" "1.036" "1.001" "1.048" "1.058" "1.079" "1.136" "1.045" "1.072" "189.1" "193.0" "196.0" "189.3" "198.3" "200.1" "204.1" "214.9" "197.6" "202.7" "" "" "" "" "" "" "" "" "" "" "151.9" "139.3" "155.6" "126.8" "137.1" "150.2" "142.9" "156.9" "197.6" "164.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4854644692515831998" "False" "High" "IsMasterProtein" "Q86X76" "Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2" "0.000" "False" "27.422" "22" "6" "7" "6" "327" "35.9" "7.74" "25.49" "6" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00795" "4817" "ENSG00000158793" "NIT1" "B1AQP3; D3DVF4; hsa:4817; O76091; Q86X76" "" "" "0" "0" "1.143" "1.057" "1.077" "1.121" "1.076" "1.037" "1.037" "1.062" "1.117" "300.5" "343.7" "317.6" "323.7" "336.8" "323.3" "311.6" "311.8" "319.1" "335.6" "" "" "" "" "" "" "" "" "" "" "241.4" "248.0" "252.3" "216.9" "232.9" "242.6" "218.2" "227.7" "319.1" "272.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059414642460420196" "False" "High" "IsMasterProtein" "P13637" "Sodium/potassium-transporting ATPase subunit alpha-3 OS=Homo sapiens OX=9606 GN=ATP1A3 PE=1 SV=3" "0.000" "False" "27.375" "7" "6" "7" "1" "1013" "111.7" "5.38" "28.23" "6" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "478" "ENSG00000105409" "ATP1A3" "B7Z2T0; B7Z401; F5H6J6; hsa:478; P13637; Q16732; Q16735; Q969K5" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "Sudden infant death syndrome (SIDS) susceptibility pathways" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1411414456407117859" "False" "High" "IsMasterProtein" "Q7Z6K3" "Protein prenyltransferase alpha subunit repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PTAR1 PE=1 SV=2" "0.000" "False" "27.348" "15" "5" "5" "5" "402" "46.4" "6.99" "18.44" "5" "" "other cell component" "other molecular function" "Pf01239" "375743" "ENSG00000188647" "PTAR1" "hsa:375743; Q5T7V5; Q5T7V6; Q7Z6K3" "" "" "0" "0" "1.037" "0.811" "0.978" "0.867" "0.809" "1.033" "1.000" "0.854" "0.970" "79.1" "82.0" "64.2" "77.3" "68.6" "64.0" "81.7" "79.1" "67.6" "76.7" "" "" "" "" "" "" "" "" "" "" "63.5" "59.2" "51.0" "51.8" "47.5" "48.0" "57.2" "57.8" "67.6" "62.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1698483045954744258" "False" "High" "IsMasterProtein" "Q15018" "BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2" "0.000" "False" "27.334" "23" "8" "10" "8" "415" "46.9" "6.21" "16.44" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21125" "23172" "ENSG00000165660" "ABRAXAS2" "B4DKR2; hsa:23172; Q15018; Q96H11" "Metalloprotease DUBs" "" "1" "0" "0.969" "0.941" "0.885" "0.981" "0.982" "1.069" "1.003" "0.983" "0.936" "246.7" "239.1" "232.2" "218.3" "242.0" "242.3" "263.6" "247.5" "242.6" "230.8" "" "" "" "" "" "" "" "" "" "" "198.1" "172.6" "184.4" "146.2" "167.4" "181.8" "184.6" "180.7" "242.6" "187.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6640745081908687038" "False" "High" "IsMasterProtein" "O75521" "Enoyl-CoA delta isomerase 2 OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" "0.000" "False" "27.325" "17" "4" "4" "4" "394" "43.6" "9.00" "16.28" "4" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00378, Pf00887" "10455" "ENSG00000198721" "ECI2" "hsa:10455; O75521; Q5JYK5; Q5JYK7; Q7L124; Q8N0X0; Q9BUE9; Q9H0T9; Q9NQH1; Q9NYH7; Q9UN55" "" "" "0" "0" "0.987" "0.947" "1.063" "0.930" "0.943" "0.973" "0.926" "0.931" "0.989" "363.1" "358.3" "343.8" "386.0" "337.9" "342.3" "353.4" "336.3" "337.9" "359.2" "" "" "" "" "" "" "" "" "" "" "291.6" "258.6" "273.1" "258.6" "233.7" "256.8" "247.4" "245.6" "337.9" "292.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5167676998188788346" "False" "High" "IsMasterProtein" "Q96EV2" "RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3" "0.000" "False" "27.319" "6" "6" "7" "6" "1170" "129.9" "6.93" "23.77" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "155435" "ENSG00000184863" "RBM33" "A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0" "" "" "0" "0" "1.002" "1.174" "1.186" "1.214" "1.006" "1.105" "1.180" "1.113" "1.190" "392.9" "393.6" "461.3" "466.1" "477.0" "395.2" "434.2" "463.5" "437.4" "467.5" "" "" "" "" "" "" "" "" "" "" "315.6" "284.0" "366.4" "312.3" "329.9" "296.5" "304.0" "338.5" "437.4" "380.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010780836197462310" "False" "High" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "0.000" "False" "27.314" "8" "2" "6" "2" "424" "44.4" "8.56" "27.34" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; 10q22q23 copy number variation" "4" "0" "0.883" "1.039" "0.894" "0.977" "1.012" "0.948" "1.031" "1.036" "0.991" "556.8" "491.7" "578.5" "497.7" "544.3" "563.8" "528.0" "573.9" "577.0" "551.8" "" "" "" "" "" "" "" "" "" "" "447.2" "354.8" "459.5" "333.5" "376.4" "423.0" "369.7" "419.1" "577.0" "448.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3951454542439150493" "False" "High" "IsMasterProtein" "Q9HB40" "Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1" "0.000" "False" "27.298" "15" "6" "7" "6" "452" "50.8" "5.81" "19.01" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00450" "59342" "ENSG00000121064" "SCPEP1" "hsa:59342; Q96A94; Q9H3F0; Q9HB40" "" "" "0" "0" "0.947" "0.982" "0.910" "0.930" "0.906" "0.837" "0.925" "0.894" "0.877" "503.6" "476.8" "494.8" "458.1" "468.6" "456.3" "421.7" "465.6" "450.4" "441.5" "" "" "" "" "" "" "" "" "" "" "404.5" "344.1" "393.0" "306.9" "324.1" "342.4" "295.3" "340.0" "450.4" "359.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4607067536077994881" "False" "High" "IsMasterProtein" "Q9Y6H1" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CHCHD2 PE=1 SV=1" "0.000" "False" "27.296" "15" "2" "7" "2" "151" "15.5" "9.22" "29.74" "2" "cell organization and biogenesis;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf06747" "51142" "ENSG00000106153" "CHCHD2" "hsa:51142; Q498C3; Q6NZ50; Q9Y6H1" "Mitochondrial protein degradation; Mitochondrial protein import" "Genetic causes of porto-sinusoidal vascular disease" "3" "0" "0.959" "0.994" "0.950" "0.911" "0.939" "0.990" "1.065" "0.943" "0.935" "1070.0" "1026.3" "1063.8" "1016.1" "974.5" "1005.2" "1059.2" "1139.2" "1008.8" "1000.9" "" "" "" "" "" "" "" "" "" "" "859.4" "740.6" "845.0" "680.8" "674.0" "754.2" "741.6" "832.0" "1008.8" "814.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3124234521907955571" "False" "High" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "0.000" "False" "27.254" "24" "2" "4" "2" "153" "17.2" "8.22" "16.79" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "1.036" "0.827" "1.073" "1.020" "0.866" "1.029" "1.151" "0.888" "0.996" "90.6" "93.9" "75.0" "97.2" "92.4" "78.5" "93.2" "104.3" "80.4" "90.3" "" "" "" "" "" "" "" "" "" "" "72.8" "67.8" "59.5" "65.1" "63.9" "58.9" "65.3" "76.1" "80.4" "73.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894202004243013211" "False" "High" "IsMasterProtein" "O15530" "3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1" "0.000" "False" "27.237" "9" "4" "5" "4" "556" "63.1" "7.36" "21.79" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf14593" "5170" "ENSG00000140992" "PDPK1" "H0Y4Z0; hsa:5170; O15530; Q59EH6; Q6FI20; Q8IV52; Q9BRD5" "Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway" "46" "0" "1.051" "0.949" "1.036" "0.979" "0.982" "0.977" "0.980" "0.903" "0.999" "466.8" "490.9" "442.8" "483.6" "457.2" "458.3" "456.2" "457.7" "421.3" "466.5" "" "" "" "" "" "" "" "" "" "" "375.0" "354.2" "351.7" "324.0" "316.2" "343.8" "319.4" "334.3" "421.3" "379.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246838135834817893" "False" "High" "IsMasterProtein" "O75362" "Zinc finger protein 217 OS=Homo sapiens OX=9606 GN=ZNF217 PE=1 SV=1" "0.000" "False" "27.200" "6" "5" "7" "5" "1048" "115.2" "8.48" "17.12" "5" "other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7764" "ENSG00000171940" "ZNF217" "E1P5Y6; hsa:7764; O75362; Q14DB8" "Estrogen-dependent gene expression" "" "1" "0" "1.063" "1.033" "1.131" "1.096" "1.009" "1.060" "1.059" "1.062" "1.121" "215.1" "228.7" "222.2" "243.3" "235.8" "217.1" "228.1" "227.8" "228.5" "241.1" "" "" "" "" "" "" "" "" "" "" "172.8" "165.0" "176.5" "163.0" "163.1" "162.9" "159.7" "166.3" "228.5" "196.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7426344905124172545" "False" "High" "IsMasterProtein" "Q9BR61" "Acyl-CoA-binding domain-containing protein 6 OS=Homo sapiens OX=9606 GN=ACBD6 PE=1 SV=1" "0.000" "False" "27.188" "21" "5" "6" "5" "282" "31.1" "5.11" "19.12" "5" "" "cytosol" "other molecular function" "Pf00887, Pf12796" "84320" "ENSG00000230124" "ACBD6" "hsa:84320; Q9BR61" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "0.990" "0.905" "0.941" "1.014" "1.047" "0.885" "0.957" "1.056" "0.986" "141.6" "140.2" "128.1" "133.3" "143.5" "148.1" "125.3" "135.4" "149.5" "139.6" "" "" "" "" "" "" "" "" "" "" "113.7" "101.1" "101.8" "89.3" "99.3" "111.1" "87.8" "98.9" "149.5" "113.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765040120545487283" "False" "High" "IsMasterProtein" "Q8IXQ6" "Protein mono-ADP-ribosyltransferase PARP9 OS=Homo sapiens OX=9606 GN=PARP9 PE=1 SV=2" "0.000" "False" "27.186" "9" "7" "7" "7" "854" "96.3" "7.91" "20.00" "7" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01661" "83666" "ENSG00000138496" "PARP9" "A8KA94; B2R8S9; E9PFM7; hsa:83666; Q8IXQ6; Q8TCP3; Q9BZL8; Q9BZL9" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "" "3" "0" "1.008" "0.995" "1.102" "1.009" "0.888" "1.047" "1.007" "0.999" "1.078" "371.0" "373.8" "369.2" "408.6" "374.3" "329.6" "388.5" "373.6" "370.6" "399.9" "" "" "" "" "" "" "" "" "" "" "297.9" "269.7" "293.3" "273.8" "258.8" "247.3" "272.0" "272.8" "370.6" "325.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993927886623036395" "False" "High" "IsMasterProtein" "P31947" "14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1" "0.000" "False" "27.170" "17" "5" "79" "1" "248" "27.8" "4.74" "192.21" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "2810" "ENSG00000175793" "SFN" "hsa:2810; P31947; Q6FH30; Q6FH51; Q96DH0" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest" "miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; p53 transcriptional gene network; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; DNA damage response" "16" "0" "0.813" "0.683" "0.687" "0.855" "0.824" "0.862" "0.966" "0.775" "0.842" "29.3" "23.8" "20.0" "20.1" "25.0" "24.1" "25.2" "28.3" "22.7" "24.7" "" "" "" "" "" "" "" "" "" "" "23.5" "17.2" "15.9" "13.5" "17.3" "18.1" "17.7" "20.7" "22.7" "20.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1008427851520544832" "False" "High" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "0.000" "False" "27.164" "8" "5" "5" "5" "808" "87.1" "9.19" "18.95" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "TBC/RABGAPs" "" "1" "0" "0.954" "0.956" "1.070" "1.021" "0.925" "1.099" "1.125" "1.145" "0.989" "592.0" "564.6" "566.1" "633.7" "604.2" "547.8" "650.7" "666.0" "677.9" "585.5" "" "" "" "" "" "" "" "" "" "" "475.5" "407.4" "449.7" "424.5" "417.9" "411.0" "455.6" "486.4" "677.9" "476.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2935309689569447405" "False" "High" "IsMasterProtein" "Q9BYD6" "Large ribosomal subunit protein uL1m OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2" "0.000" "False" "27.158" "21" "7" "8" "7" "325" "36.9" "8.78" "28.70" "7" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00687" "65008" "ENSG00000169288" "MRPL1" "A6NG03; hsa:65008; Q4W5B8; Q6IAG4; Q96BW3; Q9BYD6; Q9H793; Q9NRL5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.948" "0.972" "0.942" "0.933" "0.983" "0.967" "0.963" "0.983" "0.972" "517.2" "490.4" "502.6" "487.3" "482.7" "508.6" "500.1" "497.9" "508.6" "502.5" "" "" "" "" "" "" "" "" "" "" "415.4" "353.8" "399.2" "326.5" "333.8" "381.6" "350.2" "363.7" "508.6" "408.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5064589920710455811" "False" "High" "IsMasterProtein" "O00635" "E3 ubiquitin-protein ligase TRIM38 OS=Homo sapiens OX=9606 GN=TRIM38 PE=1 SV=1" "0.000" "False" "27.153" "13" "4" "6" "4" "465" "53.4" "7.02" "23.14" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "10475" "ENSG00000112343" "TRIM38" "B2R862; hsa:10475; O00635" "Interferon gamma signaling" "" "1" "0" "1.034" "0.968" "1.013" "1.026" "1.043" "1.067" "0.990" "1.014" "1.048" "368.5" "381.1" "356.7" "373.2" "378.2" "384.3" "393.2" "364.9" "373.5" "386.1" "" "" "" "" "" "" "" "" "" "" "296.0" "275.0" "283.4" "250.0" "261.6" "288.4" "275.3" "266.5" "373.5" "314.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8429981221702182893" "False" "High" "IsMasterProtein" "P20340" "Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3" "0.000" "False" "27.150" "24" "4" "10" "3" "208" "23.6" "5.54" "31.97" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5870" "ENSG00000175582" "RAB6A" "A8K133; B7Z772; F5H668; hsa:5870; P20340; Q1W5D8; Q5U0A8; Q9UBE4" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPI-independent Golgi-to-ER retrograde traffic; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; TBC/RABGAPs" "" "7" "0" "1.012" "1.048" "1.111" "1.279" "1.019" "0.995" "0.983" "1.048" "1.044" "218.2" "220.9" "228.7" "242.3" "279.1" "222.3" "217.1" "214.5" "228.6" "227.7" "" "" "" "" "" "" "" "" "" "" "175.2" "159.4" "181.6" "162.4" "193.0" "166.8" "152.0" "156.7" "228.6" "185.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5432716996293136503" "False" "High" "IsMasterProtein" "P05161" "Ubiquitin-like protein ISG15 OS=Homo sapiens OX=9606 GN=ISG15 PE=1 SV=5" "0.000" "False" "27.149" "48" "6" "9" "6" "165" "17.9" "7.44" "29.57" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00240" "9636" "ENSG00000187608" "ISG15" "hsa:9636; P05161; Q5SVA4; Q7Z2G2; Q96GF0" "RSV-host interactions; PKR-mediated signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "Novel intracellular components of RIG-I-like receptor pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system; Type II interferon signaling" "17" "0" "1.067" "0.952" "1.065" "1.037" "0.952" "0.941" "0.960" "0.921" "0.988" "370.2" "395.0" "352.3" "394.1" "384.1" "352.3" "348.3" "355.2" "341.0" "365.9" "" "" "" "" "" "" "" "" "" "" "297.3" "285.0" "279.8" "264.1" "265.6" "264.3" "243.9" "259.4" "341.0" "297.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090563644210438212" "False" "High" "IsMasterProtein" "Q6V1X1" "Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1" "0.000" "False" "27.148" "5" "5" "7" "4" "898" "103.3" "5.80" "27.08" "5" "protein metabolism;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "54878" "ENSG00000074603" "DPP8" "hsa:54878; Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4" "" "" "0" "0" "1.072" "1.077" "1.007" "0.990" "1.052" "1.001" "0.980" "0.983" "0.964" "419.5" "449.6" "451.8" "422.5" "415.3" "441.3" "419.7" "410.9" "412.2" "404.4" "" "" "" "" "" "" "" "" "" "" "336.9" "324.4" "358.8" "283.0" "287.3" "331.1" "293.9" "300.1" "412.2" "328.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1845643412684317790" "False" "High" "IsMasterProtein" "P49674" "Casein kinase I isoform epsilon OS=Homo sapiens OX=9606 GN=CSNK1E PE=1 SV=1" "0.000" "False" "27.137" "14" "5" "7" "2" "416" "47.3" "9.66" "22.54" "5" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "102800317; 1454" "ENSG00000213923" "CSNK1E" "hsa:102800317; hsa:1454; P49674" "Major pathway of rRNA processing in the nucleolus and cytosol; WNT mediated activation of DVL; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock" "Alzheimer's disease and miRNA effects; Melatonin metabolism and effects; Wnt signaling pathway; Wnt signaling pathway and pluripotency; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease" "20" "0" "1.147" "1.015" "1.056" "1.070" "1.014" "0.983" "1.216" "1.084" "1.025" "123.7" "141.8" "125.5" "130.6" "132.3" "125.3" "121.5" "150.3" "134.0" "126.7" "" "" "" "" "" "" "" "" "" "" "99.3" "102.3" "99.6" "87.5" "91.5" "94.0" "85.1" "109.8" "134.0" "103.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5199956621996248182" "False" "High" "IsMasterProtein" "P18859" "ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1" "0.000" "False" "27.133" "19" "2" "3" "2" "108" "12.6" "9.52" "16.54" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05511" "522" "ENSG00000154723" "ATP5PF" "hsa:522; J3KQ83; P18859" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "5" "0" "0.954" "0.850" "1.048" "0.967" "0.967" "0.858" "0.954" "0.816" "0.890" "162.4" "154.9" "138.0" "170.3" "157.1" "157.0" "139.3" "154.9" "132.6" "144.5" "" "" "" "" "" "" "" "" "" "" "130.4" "111.8" "109.6" "114.1" "108.6" "117.8" "97.5" "113.2" "132.6" "117.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3369137616140023088" "False" "High" "IsMasterProtein" "Q9NZJ9" "Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2" "0.000" "False" "27.129" "22" "4" "9" "1" "180" "20.3" "6.35" "29.21" "4" "other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000173598" "NUDT4" "B7Z916; hsa:11163; Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZJ9; Q9NZK0; Q9NZK1" "Synthesis of pyrophosphates in the cytosol" "" "1" "1" "0.997" "0.965" "1.003" "0.981" "0.917" "0.928" "1.012" "0.877" "1.036" "238.3" "237.5" "230.0" "239.1" "233.8" "218.4" "221.1" "241.2" "209.0" "246.8" "" "" "" "" "" "" "" "" "" "" "191.4" "171.4" "182.7" "160.2" "161.7" "163.9" "154.8" "176.2" "209.0" "200.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740518017781001578" "False" "High" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "0.000" "False" "27.117" "29" "5" "7" "5" "178" "18.9" "7.49" "21.30" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "1.068" "1.085" "1.144" "1.069" "1.122" "1.036" "1.091" "0.978" "1.013" "782.4" "835.4" "848.9" "895.0" "836.0" "877.7" "810.9" "853.9" "765.0" "792.6" "" "" "" "" "" "" "" "" "" "" "628.4" "602.8" "674.3" "599.7" "578.2" "658.6" "567.8" "623.6" "765.0" "644.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5232175681869918932" "False" "High" "IsMasterProtein" "Q14678" "KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KANK1 PE=1 SV=3" "0.000" "False" "27.112" "6" "7" "7" "6" "1352" "147.2" "5.30" "16.06" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00023, Pf12075" "23189" "ENSG00000107104" "KANK1" "A2A2W8; D3DRH3; hsa:23189; Q14678; Q5W0W0; Q8IY65; Q8WX74" "Estrogen-dependent gene expression; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "VEGFA-VEGFR2 signaling" "3" "0" "1.098" "0.986" "1.054" "1.100" "1.005" "1.115" "1.074" "1.115" "1.036" "542.0" "595.2" "534.6" "571.1" "596.0" "544.8" "604.6" "581.9" "604.2" "561.4" "" "" "" "" "" "" "" "" "" "" "435.3" "429.5" "424.6" "382.6" "412.2" "408.8" "423.3" "425.0" "604.2" "456.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5652857945915371988" "False" "High" "IsMasterProtein" "Q9BQ69" "ADP-ribose glycohydrolase MACROD1 OS=Homo sapiens OX=9606 GN=MACROD1 PE=1 SV=2" "0.000" "False" "27.104" "18" "5" "7" "5" "325" "35.5" "9.51" "26.78" "5" "protein metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf01661" "28992" "ENSG00000133315" "MACROD1" "hsa:28992; Q9BQ69; Q9UH96" "" "" "0" "0" "1.074" "1.063" "1.110" "1.124" "1.116" "1.116" "1.056" "1.082" "1.119" "277.9" "298.5" "295.3" "308.4" "312.4" "310.2" "310.1" "293.4" "300.6" "310.9" "" "" "" "" "" "" "" "" "" "" "223.2" "215.4" "234.6" "206.7" "216.0" "232.7" "217.1" "214.3" "300.6" "252.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667568518827666272" "False" "High" "IsMasterProtein" "O94762" "ATP-dependent DNA helicase Q5 OS=Homo sapiens OX=9606 GN=RECQL5 PE=1 SV=2" "0.000" "False" "27.092" "9" "10" "11" "10" "991" "108.8" "8.56" "29.51" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf06959, Pf16124" "9400" "ENSG00000108469" "RECQL5" "hsa:9400; O94762; Q6P4G0; Q9H0B1; Q9P1W7; Q9UNC8" "" "" "0" "0" "1.095" "0.994" "0.947" "0.919" "0.951" "0.994" "0.881" "0.921" "0.900" "218.3" "239.1" "217.1" "206.7" "200.6" "207.6" "217.0" "192.2" "201.2" "196.5" "" "" "" "" "" "" "" "" "" "" "175.4" "172.5" "172.5" "138.5" "138.7" "155.8" "151.9" "140.4" "201.2" "159.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517606527837170781" "False" "High" "IsMasterProtein" "Q9Y5P6" "Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2" "0.000" "False" "27.086" "20" "5" "6" "5" "360" "39.8" "6.61" "20.17" "5" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29925" "ENSG00000173540" "GMPPB" "A8K6N5; hsa:29925; Q9H7U3; Q9Y5P6" "Synthesis of GDP-mannose" "N-glycan biosynthesis" "2" "0" "0.994" "1.023" "1.053" "0.942" "0.923" "0.943" "0.942" "0.928" "0.960" "498.3" "495.2" "509.9" "525.0" "469.3" "459.8" "470.0" "469.3" "462.6" "478.3" "" "" "" "" "" "" "" "" "" "" "400.3" "357.3" "405.0" "351.7" "324.6" "345.0" "329.1" "342.7" "462.6" "388.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3107820624180600590" "False" "High" "IsMasterProtein" "O75879" "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1" "0.000" "False" "27.083" "15" "9" "10" "9" "557" "61.8" "8.63" "32.33" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf02637, Pf02934" "5188" "ENSG00000059691" "GATB" "hsa:5188; O75879; Q4W5M8; Q53GP4; Q9P0S6; Q9Y2B8" "" "" "0" "0" "1.017" "0.997" "1.041" "1.038" "0.989" "0.966" "0.959" "0.993" "1.010" "889.4" "904.3" "887.1" "925.5" "922.9" "879.9" "858.8" "853.3" "883.2" "898.0" "" "" "" "" "" "" "" "" "" "" "714.4" "652.5" "704.6" "620.1" "638.3" "660.2" "601.3" "623.2" "883.2" "730.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7827642572833014462" "False" "High" "IsMasterProtein" "P14649" "Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1" "0.000" "False" "27.065" "18" "4" "13" "2" "208" "22.8" "5.73" "44.58" "4" "other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "140465" "ENSG00000196465" "MYL6B" "hsa:140465; P14649" "Smooth Muscle Contraction" "Ciliary landscape" "2" "0" "0.997" "1.025" "1.018" "0.948" "1.091" "0.984" "1.015" "1.010" "0.978" "591.1" "589.5" "605.7" "602.0" "560.5" "645.1" "581.8" "599.9" "596.9" "578.0" "" "" "" "" "" "" "" "" "" "" "474.8" "425.4" "481.1" "403.4" "387.6" "484.0" "407.4" "438.1" "596.9" "470.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5940813161561783541" "False" "High" "IsMasterProtein" "Q9H078" "Mitochondrial disaggregase OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "0.000" "False" "27.064" "11" "7" "8" "7" "707" "78.7" "9.01" "21.29" "7" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "0.995" "0.948" "1.024" "1.051" "0.980" "1.026" "1.041" "1.000" "1.029" "622.4" "619.5" "590.1" "637.1" "654.2" "609.9" "638.3" "648.2" "622.7" "640.7" "" "" "" "" "" "" "" "" "" "" "499.9" "447.0" "468.7" "426.8" "452.4" "457.6" "446.9" "473.4" "622.7" "521.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238397026184103268" "False" "High" "IsMasterProtein" "Q9ULU4" "MYND-type zinc finger-containing chromatin reader ZMYND8 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2" "0.000" "False" "27.034" "4" "4" "4" "4" "1186" "131.6" "7.20" "18.05" "4" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00628, Pf00855, Pf12064" "23613" "ENSG00000101040" "ZMYND8" "B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; hsa:23613; J3KPU3; Q13517; Q2HXV1; Q2HXV2; Q2HXV3; Q2HXV4; Q2HXV7; Q2HXV8; Q2HXV9; Q2HXW0; Q2HXW1; Q2HXW2; Q4JJ94; Q4JJ95; Q5TH09; Q5TH11; Q6MZM1; Q8WXC5; Q9H1F3; Q9H1F4; Q9H1F5; Q9H1L8; Q9H1L9; Q9H2G5; Q9NYN3; Q9UIX6; Q9ULU4" "" "" "0" "0" "1.006" "1.123" "1.051" "0.985" "1.003" "1.011" "1.100" "1.028" "1.084" "365.7" "367.7" "410.5" "384.4" "360.2" "366.8" "369.8" "402.4" "376.0" "396.4" "" "" "" "" "" "" "" "" "" "" "293.7" "265.3" "326.1" "257.6" "249.1" "275.2" "258.9" "293.9" "376.0" "322.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8481404637455697567" "False" "High" "IsMasterProtein" "Q9C0B1" "Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3" "0.000" "False" "26.997" "17" "8" "10" "8" "505" "58.2" "5.22" "31.09" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12933, Pf12934" "79068" "ENSG00000140718" "FTO" "A2RUH1; B2RNS0; hsa:79068; Q0P676; Q7Z785; Q9C0B1" "Reversal of alkylation damage by DNA dioxygenases" "FTO obesity variant mechanism" "2" "0" "1.189" "1.049" "0.979" "1.214" "1.048" "0.976" "1.129" "1.177" "1.100" "161.5" "192.0" "169.5" "158.1" "196.1" "169.2" "157.6" "182.3" "190.0" "177.6" "" "" "" "" "" "" "" "" "" "" "129.7" "138.5" "134.6" "105.9" "135.6" "126.9" "110.3" "133.2" "190.0" "144.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626223979709161938" "False" "High" "IsMasterProtein" "Q9NXX6" "Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens OX=9606 GN=NSMCE4A PE=1 SV=2" "0.000" "False" "26.992" "29" "8" "9" "8" "385" "44.3" "5.38" "28.17" "8" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf08743, Pf15412" "54780" "ENSG00000107672" "NSMCE4A" "hsa:54780; Q5SQQ5; Q6P673; Q8WY66; Q9BS90; Q9NXX6" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "1.106" "1.037" "0.999" "1.014" "0.959" "0.993" "0.956" "0.988" "1.063" "388.0" "429.0" "402.3" "387.6" "393.4" "372.1" "385.3" "370.8" "383.4" "412.3" "" "" "" "" "" "" "" "" "" "" "311.6" "309.6" "319.5" "259.7" "272.1" "279.2" "269.8" "270.8" "383.4" "335.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-599104977835536313" "False" "High" "IsMasterProtein" "P28799" "Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2" "0.000" "False" "26.990" "10" "5" "6" "5" "593" "63.5" "6.83" "23.13" "5" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00396" "2896" "ENSG00000030582" "GRN" "D3DX55; hsa:2896; P23781; P23782; P23783; P23784; P28799; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0" "Neutrophil degranulation" "IL-18 signaling pathway" "2" "0" "0.963" "0.993" "1.055" "0.988" "1.071" "1.030" "1.044" "1.024" "1.037" "515.5" "496.2" "511.6" "544.1" "509.3" "551.9" "531.1" "538.0" "527.6" "534.6" "" "" "" "" "" "" "" "" "" "" "414.0" "358.0" "406.4" "364.5" "352.2" "414.1" "371.8" "392.9" "527.6" "434.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588374002070682198" "False" "High" "IsMasterProtein" "P63000" "Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens OX=9606 GN=RAC1 PE=1 SV=1" "0.000" "False" "26.977" "33" "7" "14" "2" "192" "21.4" "8.50" "44.10" "7" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5879" "ENSG00000136238" "RAC1" "hsa:5879; O95501; P15154; P63000; Q3Y4D3; Q5JAA8; Q9BTB4" "MAPK6/MAPK4 signaling; RAC1 GTPase cycle; NRAGE signals death through JNK; DCC mediated attractive signaling; Neutrophil degranulation; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; EPHB-mediated forward signaling; Ephrin signaling; EPH-ephrin mediated repulsion of cells; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; Constitutive Signaling by Aberrant PI3K in Cancer; GPVI-mediated activation cascade; Signaling by SCF-KIT; DAP12 signaling; Factors involved in megakaryocyte development and platelet production; RHO GTPases activate CIT; PCP/CE pathway; WNT5:FZD7-mediated leishmania damping; Sema3A PAK dependent Axon repulsion; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signal transduction by L1; RHO GTPases activate PKNs; RHO GTPases activate PAKs; DSCAM interactions; Azathioprine ADME; VEGFR2 mediated vascular permeability; Sema4D mediated inhibition of cell attachment and migration; Inactivation of CDC42 and RAC1; Activation of RAC1; CD28 dependent Vav1 pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction; RHO GTPases Activate NADPH Oxidases; NTRK2 activates RAC1; MET activates RAP1 and RAC1; Activation of RAC1 downstream of NMDARs; Activated NTRK2 signals through CDK5; RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Target of rapamycin signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Cardiac hypertrophic response; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Robo4 and VEGF signaling pathways crosstalk; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Ciliary landscape; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Netrin-UNC5B signaling pathway; Insulin signaling; CAMKK2 pathway; Opioid receptor pathways; Regulation of actin cytoskeleton; GDNF signaling; 2q13 copy number variation syndrome; 2q21.1 copy number variation syndrome; 2q37 copy number variation syndrome; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; TROP2 regulatory signaling; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "113" "0" "1.033" "1.043" "1.051" "0.993" "1.041" "0.980" "1.056" "1.064" "1.053" "172.0" "177.7" "179.4" "180.7" "170.8" "179.0" "168.5" "181.7" "183.0" "181.1" "" "" "" "" "" "" "" "" "" "" "138.1" "128.3" "142.5" "121.1" "118.2" "134.3" "118.0" "132.7" "183.0" "147.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1071096790058741915" "False" "High" "IsMasterProtein" "P46199" "Translation initiation factor IF-2, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF2 PE=1 SV=2" "0.000" "False" "26.966" "9" "7" "8" "7" "727" "81.3" "7.15" "24.77" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf11987" "4528" "ENSG00000085760" "MTIF2" "D6W5D0; hsa:4528; P46199" "Mitochondrial translation initiation" "" "1" "0" "0.909" "0.951" "0.898" "0.955" "0.917" "0.949" "0.939" "0.946" "0.925" "888.2" "807.6" "844.8" "797.5" "848.4" "814.7" "842.6" "834.4" "840.5" "821.6" "" "" "" "" "" "" "" "" "" "" "713.4" "582.7" "671.1" "534.3" "586.7" "611.2" "589.9" "609.4" "840.5" "668.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7123841880797263349" "False" "High" "IsMasterProtein" "P09382" "Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2" "0.000" "False" "26.959" "51" "6" "7" "6" "135" "14.7" "5.50" "22.15" "6" "cell adhesion;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00337" "3956" "ENSG00000100097" "LGALS1" "B2R5E8; hsa:3956; P09382; Q9UDK5" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Immune infiltration in pancreatic cancer" "3" "0" "1.038" "0.943" "0.907" "0.949" "1.045" "0.994" "0.959" "0.996" "1.030" "519.4" "539.1" "489.8" "470.9" "492.9" "542.9" "516.2" "498.0" "517.3" "534.7" "" "" "" "" "" "" "" "" "" "" "417.2" "389.0" "389.1" "315.5" "340.9" "407.3" "361.4" "363.7" "517.3" "434.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569062232649936506" "False" "High" "IsMasterProtein" "Q9NVH2" "Integrator complex subunit 7 OS=Homo sapiens OX=9606 GN=INTS7 PE=1 SV=1" "0.000" "False" "26.941" "9" "7" "7" "7" "962" "106.8" "8.02" "19.36" "7" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "" "25896" "ENSG00000143493" "INTS7" "B4DLZ6; B7WNP6; B7WPB6; hsa:25896; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVH2; Q9NVU5; Q9UFC6; Q9UFM3" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.091" "1.113" "1.080" "1.169" "1.150" "1.277" "1.280" "1.252" "1.122" "602.9" "657.6" "670.8" "651.4" "704.8" "693.0" "770.2" "771.8" "755.0" "676.2" "" "" "" "" "" "" "" "" "" "" "484.2" "474.5" "532.8" "436.4" "487.5" "520.0" "539.2" "563.7" "755.0" "549.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8542796064985296864" "False" "High" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "0.000" "False" "26.939" "9" "4" "4" "4" "492" "52.0" "6.48" "17.30" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "tRNA modification in the mitochondrion" "" "1" "0" "1.046" "1.004" "1.061" "0.973" "0.977" "1.043" "1.071" "1.003" "1.051" "559.2" "585.0" "561.4" "593.4" "544.1" "546.4" "583.2" "598.7" "561.1" "587.7" "" "" "" "" "" "" "" "" "" "" "449.2" "422.1" "445.9" "397.6" "376.3" "410.0" "408.3" "437.3" "561.1" "477.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1575369473679167499" "False" "High" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "0.000" "False" "26.931" "29" "8" "11" "8" "246" "29.1" "9.72" "28.63" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "9" "0" "1.094" "1.057" "1.076" "1.076" "1.110" "0.987" "0.981" "1.012" "1.026" "1258.8" "1377.2" "1330.1" "1354.7" "1354.9" "1397.8" "1241.9" "1235.5" "1273.7" "1291.1" "" "" "" "" "" "" "" "" "" "" "1011.1" "993.7" "1056.5" "907.7" "937.1" "1048.7" "869.5" "902.3" "1273.7" "1050.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801357975470055423" "False" "High" "IsMasterProtein" "O14526" "F-BAR domain only protein 1 OS=Homo sapiens OX=9606 GN=FCHO1 PE=1 SV=2" "0.000" "False" "26.899" "9" "7" "8" "7" "889" "96.8" "6.96" "26.83" "7" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00611, Pf10291" "23149" "ENSG00000130475" "FCHO1" "A6NHE6; A8K5U5; B4E120; hsa:23149; O14526; Q05C93; Q8IW22" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "1.003" "0.933" "0.937" "1.001" "0.897" "0.955" "1.006" "0.985" "0.950" "194.1" "194.6" "181.1" "181.8" "194.2" "174.1" "185.3" "195.2" "191.2" "184.4" "" "" "" "" "" "" "" "" "" "" "155.9" "140.4" "143.8" "121.8" "134.3" "130.6" "129.8" "142.6" "191.2" "150.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8342243932904844919" "False" "High" "IsMasterProtein" "Q13555" "Calcium/calmodulin-dependent protein kinase type II subunit gamma OS=Homo sapiens OX=9606 GN=CAMK2G PE=1 SV=4" "0.000" "False" "26.899" "11" "6" "8" "5" "558" "62.6" "7.83" "24.74" "6" "cell-cell signaling;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08332" "818" "ENSG00000148660" "CAMK2G" "A0A0A0MS52; A0A0A0MT11; hsa:818; O00561; O15378; Q13279; Q13282; Q13555; Q13556; Q5SQZ3; Q5SQZ4; Q5SWX4; Q7KYX5; Q8N4I3; Q8NIA4" "Signaling by BRAF and RAF1 fusions; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway" "31" "0" "1.027" "1.101" "0.879" "1.008" "1.036" "0.937" "0.995" "1.015" "0.989" "568.0" "583.1" "625.1" "499.1" "572.3" "588.3" "532.0" "565.4" "576.4" "561.9" "" "" "" "" "" "" "" "" "" "" "456.2" "420.7" "496.5" "334.4" "395.8" "441.4" "372.5" "412.9" "576.4" "457.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2769790673461720299" "False" "High" "IsMasterProtein" "Q96DF8" "Splicing factor ESS-2 homolog OS=Homo sapiens OX=9606 GN=ESS2 PE=1 SV=1" "0.000" "False" "26.889" "13" "5" "6" "5" "476" "52.5" "7.56" "15.98" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "" "Pf09751" "8220" "ENSG00000100056" "ESS2" "hsa:8220; Q49AH7; Q96DF8; Q9BTZ4" "" "22q11.2 copy number variation syndrome" "1" "0" "1.000" "0.934" "1.030" "0.971" "0.995" "0.969" "1.042" "1.047" "0.999" "477.2" "477.3" "445.8" "491.5" "463.4" "474.6" "462.5" "497.2" "499.7" "476.9" "" "" "" "" "" "" "" "" "" "" "383.3" "344.4" "354.1" "329.3" "320.5" "356.1" "323.8" "363.1" "499.7" "387.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9147063981897791280" "False" "High" "IsMasterProtein" "P04632" "Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1" "0.000" "False" "26.879" "21" "5" "9" "5" "268" "28.3" "5.20" "23.47" "5" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "" "826" "ENSG00000126247" "CAPNS1" "A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0" "Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Integrin-mediated cell adhesion" "4" "0" "1.174" "1.124" "1.258" "1.184" "1.033" "1.184" "1.318" "1.152" "1.192" "207.5" "243.7" "233.3" "261.2" "245.7" "214.5" "245.8" "273.6" "239.1" "247.4" "" "" "" "" "" "" "" "" "" "" "166.7" "175.9" "185.3" "175.0" "169.9" "160.9" "172.1" "199.8" "239.1" "201.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5045228690157758775" "False" "High" "IsMasterProtein" "Q9Y4E6" "WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=WDR7 PE=1 SV=2" "0.000" "False" "26.783" "7" "7" "7" "7" "1490" "163.7" "6.92" "19.07" "7" "other biological processes" "other cell component" "" "Pf00400" "23335" "ENSG00000091157" "WDR7" "A7E2C8; hsa:23335; Q86UX5; Q86VP2; Q96PS7; Q9Y4E6" "" "" "0" "0" "1.024" "0.937" "1.104" "1.046" "0.906" "1.056" "1.074" "0.949" "0.990" "484.1" "495.9" "453.7" "534.4" "506.1" "438.8" "511.2" "520.1" "459.5" "479.5" "" "" "" "" "" "" "" "" "" "" "388.8" "357.8" "360.4" "358.1" "350.0" "329.2" "357.9" "379.8" "459.5" "389.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1884707447535219714" "False" "High" "IsMasterProtein" "Q9BYM8" "RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=RBCK1 PE=1 SV=2" "0.000" "False" "26.749" "13" "6" "6" "6" "510" "57.5" "5.67" "19.68" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13445" "10616" "ENSG00000125826" "RBCK1" "O95623; Q86SL2; Q96BS3; Q9BYM8; Q9BYM9" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "TAR syndrome" "5" "0" "0.958" "0.938" "0.977" "0.983" "0.931" "0.926" "0.961" "0.974" "0.968" "462.1" "442.9" "433.3" "451.6" "454.3" "430.4" "427.9" "444.1" "450.1" "447.4" "" "" "" "" "" "" "" "" "" "" "371.1" "319.5" "344.2" "302.6" "314.2" "322.9" "299.6" "324.3" "450.1" "363.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1498458301552967093" "False" "High" "IsMasterProtein" "P13716" "Delta-aminolevulinic acid dehydratase OS=Homo sapiens OX=9606 GN=ALAD PE=1 SV=1" "0.000" "False" "26.713" "18" "5" "7" "5" "330" "36.3" "6.79" "30.40" "5" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00490" "210" "ENSG00000148218" "ALAD" "A8K375; B2R6F2; hsa:210; P13716; Q16870; Q16871; Q9BVQ9" "Neutrophil degranulation; Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "4" "0" "1.175" "1.107" "1.303" "1.302" "1.236" "1.229" "1.136" "1.200" "1.163" "133.4" "156.7" "147.7" "173.8" "173.6" "164.9" "163.9" "151.5" "160.0" "155.1" "" "" "" "" "" "" "" "" "" "" "107.1" "113.1" "117.3" "116.4" "120.0" "123.7" "114.7" "110.7" "160.0" "126.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602671086497481481" "False" "High" "IsMasterProtein" "O43709" "18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "0.000" "False" "26.686" "19" "4" "7" "4" "281" "31.9" "8.73" "24.34" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "7q11.23 copy number variation syndrome" "3" "0" "1.048" "1.097" "1.007" "1.063" "1.048" "1.007" "1.010" "1.016" "0.986" "664.0" "696.1" "728.0" "668.6" "705.8" "695.9" "668.7" "670.9" "674.4" "654.4" "" "" "" "" "" "" "" "" "" "" "533.3" "502.3" "578.3" "448.0" "488.1" "522.1" "468.2" "490.0" "674.4" "532.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-597243898993742241" "False" "High" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "0.000" "False" "26.675" "30" "3" "22" "3" "107" "11.7" "10.32" "77.06" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "13" "0" "0.983" "1.035" "1.068" "1.046" "1.069" "1.123" "1.092" "1.073" "1.024" "2653.6" "2608.9" "2745.2" "2834.3" "2775.1" "2837.1" "2980.1" "2896.9" "2848.6" "2716.1" "" "" "" "" "" "" "" "" "" "" "2131.4" "1882.5" "2180.6" "1899.0" "1919.3" "2128.6" "2086.5" "2115.6" "2848.6" "2208.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260293505055803748" "False" "High" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "0.000" "False" "26.673" "3" "6" "6" "6" "2229" "242.8" "8.34" "20.31" "6" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "0.931" "0.966" "1.078" "1.063" "0.978" "1.255" "0.873" "1.084" "1.122" "146.7" "136.6" "141.7" "158.2" "155.9" "143.5" "184.1" "128.0" "159.0" "164.6" "" "" "" "" "" "" "" "" "" "" "117.8" "98.6" "112.5" "106.0" "107.9" "107.7" "128.9" "93.5" "159.0" "133.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3163566102457861060" "False" "High" "IsMasterProtein" "Q8IWI9" "MAX gene-associated protein OS=Homo sapiens OX=9606 GN=MGA PE=1 SV=4" "0.000" "False" "26.620" "3" "6" "6" "6" "3065" "336.0" "6.90" "18.53" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00907, Pf16059" "23269" "ENSG00000174197" "MGA" "B9EGR5; E7ENI0; F5H7K2; hsa:23269; Q8IWI9; Q9H8R3; Q9H9N7; Q9UG69; Q9Y4E9" "Transcriptional Regulation by E2F6" "Pathways affected in adenoid cystic carcinoma" "2" "0" "1.063" "1.076" "1.179" "1.077" "1.036" "1.062" "1.078" "1.129" "1.129" "252.1" "267.9" "271.2" "297.2" "271.4" "261.0" "267.7" "271.8" "284.6" "284.5" "" "" "" "" "" "" "" "" "" "" "202.4" "193.3" "215.4" "199.1" "187.7" "195.8" "187.5" "198.5" "284.6" "231.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4713550819086734085" "False" "High" "IsMasterProtein" "Q96AT9" "Ribulose-phosphate 3-epimerase OS=Homo sapiens OX=9606 GN=RPE PE=1 SV=1" "0.000" "False" "26.613" "15" "3" "6" "3" "228" "24.9" "5.58" "24.27" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf00834" "6120" "ENSG00000197713" "RPE" "A8K4S0; B4E016; C9JPQ7; hsa:6120; O43767; Q53TV9; Q8N215; Q96AT9; Q96N34; Q9BSB5" "Pentose phosphate pathway" "Pentose phosphate metabolism; Pentose phosphate pathway in senescent cells" "3" "0" "0.960" "0.943" "0.996" "0.919" "0.995" "0.968" "0.814" "0.912" "0.932" "657.2" "630.8" "619.8" "654.6" "603.7" "653.8" "636.2" "534.8" "599.3" "612.3" "" "" "" "" "" "" "" "" "" "" "527.8" "455.2" "492.3" "438.6" "417.5" "490.5" "445.5" "390.5" "599.3" "498.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449517754761536848" "False" "High" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "0.000" "False" "26.600" "34" "8" "9" "8" "227" "26.5" "8.41" "32.06" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "" "2" "0" "0.978" "0.944" "0.941" "0.964" "0.909" "0.869" "0.956" "0.904" "0.967" "1892.6" "1850.8" "1786.2" "1780.0" "1823.6" "1720.8" "1644.4" "1810.2" "1711.6" "1830.5" "" "" "" "" "" "" "" "" "" "" "1520.1" "1335.5" "1418.8" "1192.6" "1261.2" "1291.1" "1151.3" "1322.0" "1711.6" "1488.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991702239922079005" "False" "High" "IsMasterProtein" "A0A024RBG1" "Diphosphoinositol polyphosphate phosphohydrolase NUDT4B OS=Homo sapiens OX=9606 GN=NUDT4B PE=3 SV=1" "0.000" "False" "26.579" "23" "4" "7" "1" "181" "20.4" "6.35" "25.44" "4" "other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000177144" "NUDT4B" "A0A024RBG1" "" "" "0" "0" "1.025" "1.099" "1.145" "1.116" "1.111" "1.006" "1.018" "1.002" "1.144" "145.1" "148.7" "159.5" "166.1" "161.9" "161.3" "146.1" "147.7" "145.4" "166.1" "" "" "" "" "" "" "" "" "" "" "116.6" "107.3" "126.7" "111.3" "112.0" "121.0" "102.3" "107.9" "145.4" "135.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2083560476411538397" "False" "High" "IsMasterProtein" "O15047" "Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3" "0.000" "False" "26.575" "5" "7" "7" "7" "1707" "185.9" "5.14" "20.88" "7" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00856, Pf11764" "9739" "ENSG00000099381" "SETD1A" "A6NP62; hsa:9739; O15047; Q6PIF3; Q8TAJ6" "Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Histone modifications" "4" "0" "1.011" "0.944" "1.038" "1.038" "1.018" "0.978" "1.039" "0.991" "1.034" "323.4" "327.0" "305.1" "335.6" "335.8" "329.2" "316.2" "336.0" "320.6" "334.5" "" "" "" "" "" "" "" "" "" "" "259.7" "236.0" "242.4" "224.8" "232.2" "247.0" "221.4" "245.4" "320.6" "272.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5418508312129097166" "False" "High" "IsMasterProtein" "P35626" "G protein-coupled receptor kinase 3 OS=Homo sapiens OX=9606 GN=GRK3 PE=1 SV=2" "0.000" "False" "26.574" "6" "3" "6" "1" "688" "79.7" "7.62" "17.70" "3" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "157" "ENSG00000100077" "GRK3" "hsa:157; P35626; Q9UGW9" "G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis" "Corticotropin-releasing hormone signaling pathway; Hedgehog signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7828842707520281021" "False" "High" "IsMasterProtein" "P41223" "Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2" "0.000" "False" "26.524" "41" "7" "7" "7" "144" "17.0" "8.82" "21.19" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01125" "8896" "ENSG00000106245" "BUD31" "A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1" "mRNA Splicing - Major Pathway" "" "1" "0" "1.050" "1.119" "1.229" "1.139" "1.169" "1.104" "1.137" "1.179" "1.194" "496.8" "521.6" "555.9" "610.7" "565.7" "580.8" "548.4" "564.7" "585.7" "593.2" "" "" "" "" "" "" "" "" "" "" "399.1" "376.3" "441.6" "409.2" "391.2" "435.7" "384.0" "412.4" "585.7" "482.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249152470973198342" "False" "High" "IsMasterProtein" "Q9NYZ3" "G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=4" "0.000" "False" "26.500" "12" "7" "7" "7" "739" "78.5" "9.23" "23.80" "7" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15259" "51512" "ENSG00000075218" "GTSE1" "B0QYM3; hsa:51512; Q20WK2; Q53GX5; Q5R3I6; Q6DHX4; Q9BRE0; Q9NYZ3; Q9UGZ9; Q9Y557" "G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint" "" "2" "0" "1.243" "1.386" "1.373" "1.353" "1.315" "1.551" "1.364" "1.577" "1.264" "45.1" "56.1" "62.5" "61.9" "61.1" "59.3" "70.0" "61.6" "71.2" "57.0" "" "" "" "" "" "" "" "" "" "" "36.2" "40.5" "49.7" "41.5" "42.2" "44.5" "49.0" "45.0" "71.2" "46.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629432555354117988" "False" "High" "IsMasterProtein" "P78537" "Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Homo sapiens OX=9606 GN=BLOC1S1 PE=1 SV=2" "0.000" "False" "26.488" "30" "5" "8" "5" "153" "17.3" "9.33" "26.43" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "" "Pf06320" "2647" "ENSG00000135441" "BLOC1S1" "A1L4Q9; hsa:2647; P78537; Q6NZ45" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "Alstrom syndrome" "3" "0" "1.028" "0.964" "0.944" "0.929" "0.926" "1.003" "0.959" "0.956" "0.989" "799.7" "822.0" "770.7" "754.7" "743.2" "740.4" "802.0" "767.3" "764.6" "791.1" "" "" "" "" "" "" "" "" "" "" "642.3" "593.1" "612.2" "505.7" "514.0" "555.5" "561.5" "560.4" "764.6" "643.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585916410181359903" "False" "High" "IsMasterProtein" "Q6IQ49" "Splicing regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1" "0.000" "False" "26.461" "18" "8" "11" "8" "451" "49.7" "6.05" "28.62" "8" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf13019, Pf13297" "163859" "ENSG00000143751" "SDE2" "A8K4P3; hsa:163859; Q5TD36; Q6IQ49; Q6ZS26; Q8NAG7" "mRNA Splicing - Major Pathway" "" "1" "0" "1.083" "1.022" "1.137" "1.046" "1.043" "1.053" "1.025" "0.997" "1.020" "733.2" "794.3" "749.2" "833.3" "766.9" "764.4" "771.7" "751.5" "730.6" "748.1" "" "" "" "" "" "" "" "" "" "" "588.9" "573.1" "595.1" "558.3" "530.4" "573.5" "540.3" "548.8" "730.6" "608.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939061422699868951" "False" "High" "IsMasterProtein" "Q92618" "Zinc finger protein 516 OS=Homo sapiens OX=9606 GN=ZNF516 PE=1 SV=1" "0.000" "False" "26.460" "7" "7" "7" "7" "1163" "124.2" "8.72" "24.40" "7" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "9658" "ENSG00000101493" "ZNF516" "hsa:9658; Q92618" "" "Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects" "2" "0" "1.081" "1.001" "1.273" "1.204" "0.994" "1.189" "1.162" "1.024" "1.068" "417.0" "450.8" "417.3" "530.7" "502.3" "414.4" "496.0" "484.4" "426.9" "445.5" "" "" "" "" "" "" "" "" "" "" "335.0" "325.3" "331.4" "355.6" "347.4" "310.9" "347.3" "353.8" "426.9" "362.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1136276274869286846" "False" "High" "IsMasterProtein" "Q9NVR2" "Integrator complex subunit 10 OS=Homo sapiens OX=9606 GN=INTS10 PE=1 SV=2" "0.000" "False" "26.447" "10" "6" "8" "6" "710" "82.2" "7.44" "18.38" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf21045" "55174" "ENSG00000104613" "INTS10" "hsa:55174; Q6IA93; Q7L538; Q7L8C8; Q9H3W8; Q9NVR2" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "0.955" "1.115" "1.089" "1.340" "1.081" "1.004" "1.200" "1.075" "1.050" "122.4" "116.8" "136.5" "133.2" "163.9" "132.3" "122.8" "146.8" "131.6" "128.5" "" "" "" "" "" "" "" "" "" "" "98.3" "84.3" "108.4" "89.3" "113.4" "99.3" "86.0" "107.2" "131.6" "104.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7473966995224482536" "False" "High" "IsMasterProtein" "Q13233" "Mitogen-activated protein kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP3K1 PE=1 SV=4" "0.000" "False" "26.425" "5" "6" "7" "6" "1512" "164.4" "7.74" "23.85" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf04434, Pf21040" "4214" "ENSG00000095015" "MAP3K1" "hsa:4214; Q13233" "FCERI mediated MAPK activation; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; TRAF6 mediated NF-kB activation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane" "IL-1 signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Oxidative damage response; PDGFR-beta pathway; p38 MAPK signaling pathway; MAPK cascade; EGF/EGFR signaling pathway; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Hepatitis B infection; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "32" "0" "1.030" "1.042" "1.076" "1.016" "1.029" "0.981" "1.028" "1.010" "1.121" "216.2" "222.6" "225.2" "232.6" "219.6" "222.4" "212.1" "222.1" "218.3" "242.4" "" "" "" "" "" "" "" "" "" "" "173.6" "160.6" "178.9" "155.8" "151.9" "166.8" "148.5" "162.2" "218.3" "197.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3194956700439507601" "False" "High" "IsMasterProtein" "Q9UPT5" "Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3" "0.000" "False" "26.410" "9" "6" "6" "6" "735" "83.3" "6.79" "21.35" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03081, Pf20669" "23265" "ENSG00000182473" "EXOC7" "B5MC69; B8XXP2; hsa:23265; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32; Q9UPT5" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Angiopoietin-like protein 8 regulatory pathway; Ciliary landscape" "5" "0" "0.985" "0.972" "1.027" "1.018" "1.007" "0.999" "1.057" "1.080" "0.967" "504.9" "497.1" "490.7" "518.7" "513.8" "508.5" "504.5" "533.4" "545.4" "488.4" "" "" "" "" "" "" "" "" "" "" "405.5" "358.7" "389.7" "347.5" "355.4" "381.5" "353.2" "389.6" "545.4" "397.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2101401554741180333" "False" "High" "IsMasterProtein" "Q8N5M1" "ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1" "0.000" "False" "26.402" "11" "3" "6" "3" "289" "32.8" "7.09" "25.61" "3" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "" "Pf07542" "91647" "ENSG00000171953" "ATPAF2" "A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1" "" "7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "0.960" "1.004" "1.027" "0.892" "0.934" "0.960" "0.948" "1.002" "0.907" "214.1" "205.6" "215.0" "219.8" "190.9" "199.9" "205.6" "203.0" "214.7" "194.3" "" "" "" "" "" "" "" "" "" "" "172.0" "148.4" "170.8" "147.3" "132.1" "150.0" "143.9" "148.3" "214.7" "158.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901270763620924094" "False" "High" "IsMasterProtein" "Q6P1N9" "Deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "0.000" "False" "26.399" "19" "5" "6" "5" "297" "33.6" "6.96" "19.80" "5" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687; ENSG00000291730" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "0.943" "0.932" "0.926" "0.928" "0.877" "0.989" "0.987" "0.834" "0.925" "166.6" "157.1" "155.2" "154.2" "154.5" "146.0" "164.7" "164.3" "139.0" "154.0" "" "" "" "" "" "" "" "" "" "" "133.8" "113.3" "123.3" "103.3" "106.8" "109.6" "115.3" "120.0" "139.0" "125.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128972635678329678" "False" "High" "IsMasterProtein" "Q9BUT1" "Dehydrogenase/reductase SDR family member 6 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "0.000" "False" "26.387" "29" "6" "6" "6" "245" "26.7" "7.65" "23.29" "6" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "Synthesis of Ketone Bodies" "" "1" "0" "1.023" "0.983" "1.057" "1.027" "1.031" "1.060" "1.007" "1.010" "0.977" "457.8" "468.4" "449.8" "483.8" "470.4" "471.8" "485.3" "461.1" "462.4" "447.2" "" "" "" "" "" "" "" "" "" "" "367.7" "338.0" "357.3" "324.1" "325.3" "354.0" "339.8" "336.8" "462.4" "363.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1384123657554198198" "False" "High" "IsMasterProtein" "Q8NHQ9" "ATP-dependent RNA helicase DDX55 OS=Homo sapiens OX=9606 GN=DDX55 PE=1 SV=3" "0.000" "False" "26.381" "11" "5" "6" "5" "600" "68.5" "9.25" "15.74" "5" "" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf13959" "57696" "ENSG00000111364" "DDX55" "hsa:57696; Q658L6; Q8IYH0; Q8NHQ9; Q9HCH7" "" "" "0" "0" "1.040" "1.165" "1.156" "1.079" "1.111" "1.249" "1.110" "1.114" "1.066" "184.0" "191.4" "214.4" "212.8" "198.5" "204.3" "229.8" "204.3" "205.0" "196.1" "" "" "" "" "" "" "" "" "" "" "147.8" "138.1" "170.3" "142.6" "137.3" "153.3" "160.9" "149.2" "205.0" "159.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682819818401791106" "False" "High" "IsMasterProtein" "Q9NZJ0" "Denticleless protein homolog OS=Homo sapiens OX=9606 GN=DTL PE=1 SV=3" "0.000" "False" "26.380" "9" "7" "9" "7" "730" "79.4" "8.87" "26.27" "7" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "51514" "ENSG00000143476" "DTL" "A8K8H8; D3DT98; hsa:51514; Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; Q9NZJ0" "Neddylation; Recognition of DNA damage by PCNA-containing replication complex" "" "2" "0" "1.014" "1.087" "1.011" "1.039" "0.975" "1.663" "1.788" "1.660" "1.232" "464.7" "471.1" "505.4" "470.0" "482.9" "453.0" "772.6" "830.8" "771.6" "572.5" "" "" "" "" "" "" "" "" "" "" "373.3" "339.9" "401.4" "314.9" "333.9" "339.9" "541.0" "606.7" "771.6" "465.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-398928808883879512" "False" "High" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "0.000" "False" "26.352" "42" "4" "7" "4" "99" "11.3" "9.31" "27.31" "4" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "1.019" "0.973" "0.994" "1.013" "1.046" "1.036" "1.121" "1.032" "1.001" "820.7" "836.2" "798.3" "816.0" "831.3" "858.6" "850.6" "920.4" "847.2" "821.9" "" "" "" "" "" "" "" "" "" "" "659.2" "603.4" "634.2" "546.7" "574.9" "644.2" "595.6" "672.2" "847.2" "668.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6462118287367883221" "False" "High" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "0.000" "False" "26.345" "34" "7" "11" "7" "219" "24.3" "6.21" "30.34" "7" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "" "3" "0" "1.042" "1.045" "1.061" "1.065" "1.061" "1.099" "1.089" "1.065" "1.069" "708.9" "738.9" "740.5" "752.2" "754.9" "752.0" "778.8" "771.9" "754.6" "757.6" "" "" "" "" "" "" "" "" "" "" "569.4" "533.1" "588.2" "504.0" "522.1" "564.2" "545.3" "563.7" "754.6" "616.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518477556068487686" "False" "High" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "0.000" "False" "26.345" "33" "4" "15" "4" "118" "12.7" "7.30" "38.78" "4" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "1.091" "1.050" "1.189" "1.040" "1.016" "1.046" "0.941" "0.836" "0.957" "550.5" "600.5" "578.2" "654.8" "572.5" "559.5" "576.1" "518.2" "460.1" "526.9" "" "" "" "" "" "" "" "" "" "" "442.2" "433.3" "459.3" "438.7" "396.0" "419.8" "403.3" "378.4" "460.1" "428.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1208810271641948454" "False" "High" "IsMasterProtein" "Q8NEL9" "Phospholipase DDHD1 OS=Homo sapiens OX=9606 GN=DDHD1 PE=1 SV=2" "0.000" "False" "26.317" "6" "5" "6" "5" "900" "100.4" "5.67" "24.48" "5" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02862" "80821" "ENSG00000100523" "DDHD1" "G5E9D1; hsa:80821; Q8NEL9; Q8WVH3; Q96LL2; Q9C0F8" "Synthesis of PA" "" "1" "0" "0.969" "0.887" "1.020" "0.894" "0.871" "0.821" "0.910" "0.943" "0.930" "371.1" "359.4" "329.3" "378.6" "331.8" "323.2" "304.7" "337.6" "350.0" "344.9" "" "" "" "" "" "" "" "" "" "" "298.1" "259.4" "261.5" "253.7" "229.5" "242.5" "213.4" "246.5" "350.0" "280.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695777178307527150" "False" "High" "IsMasterProtein" "Q9BZL1" "Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1" "0.000" "False" "26.316" "68" "4" "9" "4" "73" "8.5" "8.44" "26.08" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00240" "59286" "ENSG00000198258" "UBL5" "hsa:59286; Q2NL89; Q9BZL1" "mRNA Splicing - Major Pathway" "" "1" "0" "0.981" "1.026" "1.041" "1.121" "1.028" "1.190" "1.081" "0.998" "1.033" "637.2" "625.0" "653.6" "663.0" "714.5" "655.1" "758.3" "688.6" "635.8" "658.2" "" "" "" "" "" "" "" "" "" "" "511.8" "451.0" "519.2" "444.2" "494.2" "491.5" "530.9" "502.9" "635.8" "535.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2659505507426523226" "False" "High" "IsMasterProtein" "P0CAP2" "DNA-directed RNA polymerase II subunit GRINL1A OS=Homo sapiens OX=9606 GN=POLR2M PE=1 SV=1" "0.000" "False" "26.310" "15" "5" "5" "5" "368" "41.7" "6.39" "20.10" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15328" "81488" "ENSG00000255529" "POLR2M" "hsa:81488; P0CAP2; Q6EER8; Q6EES2; Q6EEV3; Q6EF00; Q6EF01; Q6EF02; Q6EF46; Q6EFN8; Q6EM48; Q6K046; Q6K050; Q6K051; Q6ZQZ3; Q8NC58; Q8NCF3; Q96DI5; Q96JB7; Q96NF5; Q9Y3V6" "" "" "0" "0" "1.082" "1.104" "1.096" "1.019" "1.061" "1.113" "1.125" "1.184" "1.093" "403.1" "436.1" "445.1" "441.7" "410.7" "427.8" "448.8" "453.6" "477.2" "440.8" "" "" "" "" "" "" "" "" "" "" "323.8" "314.7" "353.5" "296.0" "284.1" "321.0" "314.2" "331.2" "477.2" "358.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "710012249327667382" "False" "High" "IsMasterProtein" "P48449" "Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1" "0.000" "False" "26.305" "11" "7" "7" "7" "732" "83.3" "6.61" "22.15" "7" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00432" "4047" "ENSG00000160285" "LSS" "B4DJZ9; D3DSN0; E9PEI9; G5E9Q9; P48449; Q8IYL6; Q9UEZ1" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "1.004" "0.936" "1.048" "0.983" "0.904" "1.037" "0.952" "1.029" "0.933" "397.0" "398.5" "371.5" "416.2" "390.4" "359.0" "411.6" "378.1" "408.3" "370.5" "" "" "" "" "" "" "" "" "" "" "318.9" "287.5" "295.1" "278.8" "270.0" "269.4" "288.2" "276.1" "408.3" "301.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652533075202528091" "False" "High" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "0.000" "False" "26.299" "16" "4" "7" "4" "400" "43.4" "5.10" "25.70" "4" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport" "" "2" "0" "0.942" "0.910" "0.993" "0.914" "0.965" "0.977" "0.914" "0.868" "0.889" "329.8" "310.7" "300.0" "327.6" "301.4" "318.3" "322.3" "301.4" "286.2" "293.1" "" "" "" "" "" "" "" "" "" "" "264.9" "224.2" "238.3" "219.5" "208.4" "238.8" "225.7" "220.1" "286.2" "238.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3637812855525000132" "False" "High" "IsMasterProtein" "Q2KHR2" "DNA-binding protein RFX7 OS=Homo sapiens OX=9606 GN=RFX7 PE=1 SV=2" "0.000" "False" "26.292" "5" "6" "6" "6" "1460" "157.3" "6.61" "19.90" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257" "64864" "ENSG00000181827" "RFX7" "hsa:64864; Q2KHR2; Q6ZRR1; Q6ZTY6; Q8N3J0; Q9H7A9; Q9H956" "" "" "0" "0" "0.958" "0.976" "0.948" "0.935" "0.937" "0.936" "0.993" "0.949" "1.008" "294.1" "281.7" "287.1" "278.9" "275.0" "275.6" "275.4" "292.0" "279.2" "296.5" "" "" "" "" "" "" "" "" "" "" "236.2" "203.3" "228.1" "186.9" "190.2" "206.8" "192.8" "213.2" "279.2" "241.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4837224883862522345" "False" "High" "IsMasterProtein" "Q9BYD1" "Large ribosomal subunit protein uL13m OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" "0.000" "False" "26.274" "39" "6" "8" "6" "178" "20.7" "9.16" "27.29" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00572" "28998" "ENSG00000172172" "MRPL13" "B2R4R8; hsa:28998; Q9BYD1; Q9UI04" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.941" "0.948" "1.048" "1.023" "0.959" "0.914" "0.958" "0.893" "0.972" "499.1" "469.7" "473.4" "523.1" "510.4" "478.6" "456.4" "478.3" "445.7" "484.9" "" "" "" "" "" "" "" "" "" "" "400.9" "339.0" "376.0" "350.5" "353.0" "359.1" "319.5" "349.3" "445.7" "394.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1352490875980109709" "False" "High" "IsMasterProtein" "Q5VVQ6" "Ubiquitin thioesterase OTU1 OS=Homo sapiens OX=9606 GN=YOD1 PE=1 SV=1" "0.000" "False" "26.225" "20" "6" "6" "6" "348" "38.3" "6.11" "19.59" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02338, Pf21403" "55432" "ENSG00000180667" "YOD1" "B2RNX3; hsa:55432; Q5VVQ5; Q5VVQ6; Q6ZRS6; Q86T63; Q9P1L8" "Ovarian tumor domain proteases" "" "1" "0" "0.977" "0.956" "0.909" "0.978" "0.955" "0.916" "0.942" "0.960" "0.981" "574.6" "561.5" "549.2" "522.6" "562.2" "548.7" "526.1" "541.1" "551.8" "563.8" "" "" "" "" "" "" "" "" "" "" "461.5" "405.2" "436.2" "350.2" "388.8" "411.7" "368.3" "395.2" "551.8" "458.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1591325911363533533" "False" "High" "IsMasterProtein" "Q8NFV4" "sn-1-specific diacylglycerol lipase ABHD11 OS=Homo sapiens OX=9606 GN=ABHD11 PE=1 SV=2" "0.000" "False" "26.220" "19" "5" "7" "5" "306" "33.7" "9.19" "22.38" "5" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00561" "83451" "ENSG00000106077" "ABHD11" "H7BYM8; hsa:83451; Q6PJU0; Q8N722; Q8N723; Q8NFV2; Q8NFV3; Q8NFV4; Q9HBS8" "" "7q11.23 copy number variation syndrome" "1" "0" "0.936" "0.986" "1.047" "0.999" "0.906" "0.954" "0.968" "0.987" "1.007" "397.0" "371.5" "391.6" "415.8" "396.7" "359.6" "378.7" "384.5" "391.9" "400.0" "" "" "" "" "" "" "" "" "" "" "318.9" "268.1" "311.1" "278.6" "274.4" "269.8" "265.2" "280.8" "391.9" "325.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4942654517427891889" "False" "High" "IsMasterProtein" "Q9H6D7" "HAUS augmin-like complex subunit 4 OS=Homo sapiens OX=9606 GN=HAUS4 PE=1 SV=1" "0.000" "False" "26.216" "19" "6" "6" "6" "363" "42.4" "5.68" "20.34" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14735" "54930" "ENSG00000092036" "HAUS4" "B7WP17; D3DS34; hsa:54930; Q86T15; Q86T16; Q86U43; Q9H6D7; Q9NX59" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.001" "1.029" "0.972" "1.011" "1.085" "1.004" "1.046" "1.009" "1.049" "626.3" "626.8" "644.4" "608.6" "633.2" "679.4" "628.7" "655.2" "632.0" "657.3" "" "" "" "" "" "" "" "" "" "" "503.0" "452.3" "511.9" "407.8" "437.9" "509.7" "440.2" "478.5" "632.0" "534.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288326920404565316" "False" "High" "IsMasterProtein" "O15111" "Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Homo sapiens OX=9606 GN=CHUK PE=1 SV=2" "0.000" "False" "26.214" "11" "7" "7" "6" "745" "84.6" "6.73" "25.45" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "1147" "ENSG00000213341" "CHUK" "hsa:1147; O14666; O15111; Q13132; Q5W0I4; Q92467" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; AKT phosphorylates targets in the cytosol" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "86" "0" "1.001" "0.949" "0.968" "0.957" "1.037" "0.953" "0.979" "0.884" "0.992" "318.3" "318.8" "302.3" "308.3" "304.8" "330.2" "303.5" "311.6" "281.5" "315.7" "" "" "" "" "" "" "" "" "" "" "255.7" "230.0" "240.1" "206.5" "210.8" "247.8" "212.5" "227.5" "281.5" "256.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-325919897552027140" "False" "High" "IsMasterProtein" "Q9NW08" "DNA-directed RNA polymerase III subunit RPC2 OS=Homo sapiens OX=9606 GN=POLR3B PE=1 SV=2" "0.000" "False" "26.194" "7" "9" "10" "9" "1133" "127.7" "8.50" "25.26" "9" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "55703" "ENSG00000013503" "POLR3B" "A8K6H0; B3KV73; F5H1E6; hsa:55703; Q9NW08; Q9NW59" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "1.017" "0.965" "0.982" "1.023" "0.985" "1.017" "1.015" "0.995" "1.019" "789.4" "802.6" "761.9" "775.4" "807.9" "777.7" "802.8" "801.6" "785.6" "804.1" "" "" "" "" "" "" "" "" "" "" "634.0" "579.1" "605.2" "519.5" "558.7" "583.5" "562.1" "585.4" "785.6" "653.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7131720843867798084" "False" "High" "IsMasterProtein" "Q9BT09" "Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1" "0.000" "False" "26.185" "19" "5" "7" "5" "278" "30.7" "5.49" "26.07" "5" "stress response" "ER/Golgi" "signal transduction activity or receptor binding" "Pf11938" "10695" "ENSG00000137161" "CNPY3" "hsa:10695; O15412; Q0P6I2; Q8NF54; Q8WTU8; Q9BT09; Q9P0F2" "Trafficking and processing of endosomal TLR" "" "1" "0" "1.362" "1.118" "1.117" "1.121" "1.149" "1.128" "1.060" "1.148" "1.095" "707.0" "963.2" "790.8" "789.6" "792.5" "812.6" "797.5" "749.5" "811.6" "774.0" "" "" "" "" "" "" "" "" "" "" "567.9" "695.0" "628.1" "529.0" "548.1" "609.7" "558.4" "547.4" "811.6" "629.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8388783144784420231" "False" "High" "IsMasterProtein" "P82930" "Small ribosomal subunit protein mS34 OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" "0.000" "False" "26.162" "34" "6" "6" "6" "218" "25.6" "9.98" "22.92" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf16053" "65993" "ENSG00000074071" "MRPS34" "hsa:65993; P82930; Q9BVI7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.083" "1.049" "1.059" "0.968" "1.016" "0.912" "1.057" "0.942" "1.017" "467.3" "505.9" "490.3" "494.9" "452.1" "474.6" "426.1" "493.9" "440.1" "475.3" "" "" "" "" "" "" "" "" "" "" "375.3" "365.0" "389.5" "331.6" "312.7" "356.1" "298.3" "360.7" "440.1" "386.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5860856138791644160" "False" "High" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "0.000" "False" "26.128" "7" "5" "11" "2" "579" "62.3" "8.79" "37.74" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "0" "1.018" "1.031" "1.091" "0.972" "1.085" "1.096" "1.096" "1.018" "1.032" "336.9" "343.0" "347.4" "367.5" "327.4" "365.6" "369.1" "369.2" "342.9" "347.8" "" "" "" "" "" "" "" "" "" "" "270.6" "247.5" "276.0" "246.2" "226.5" "274.3" "258.4" "269.6" "342.9" "282.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677605172328813102" "False" "High" "IsMasterProtein" "Q6IAA8" "Ragulator complex protein LAMTOR1 OS=Homo sapiens OX=9606 GN=LAMTOR1 PE=1 SV=2" "0.000" "False" "26.039" "23" "2" "5" "2" "161" "17.7" "5.15" "14.71" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15454" "55004" "ENSG00000149357" "LAMTOR1" "hsa:55004; Q6IAA8; Q8WZ09; Q9NWT0" "Regulation of PTEN gene transcription; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Neutrophil degranulation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; Amino acids regulate mTORC1; RHOJ GTPase cycle; mTORC1-mediated signalling; RHOH GTPase cycle" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "17" "0" "1.056" "1.061" "1.074" "1.205" "1.061" "1.222" "1.093" "1.011" "0.976" "111.4" "117.7" "118.2" "119.6" "134.2" "118.1" "136.1" "121.8" "112.6" "108.7" "" "" "" "" "" "" "" "" "" "" "89.5" "84.9" "93.9" "80.2" "92.8" "88.6" "95.3" "88.9" "112.6" "88.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036196760614096612" "False" "High" "IsMasterProtein" "P11802" "Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2" "0.000" "False" "26.015" "18" "6" "8" "5" "303" "33.7" "7.01" "28.35" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "1019" "ENSG00000135446" "CDK4" "B2R9A0; B4DNF9; hsa:1019; O00576; P11802; Q6FG61" "Oxidative Stress Induced Senescence; Transcriptional regulation of white adipocyte differentiation; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; Transcriptional regulation by RUNX2; Meiotic recombination; Transcriptional regulation of granulopoiesis; PTK6 Regulates Cell Cycle; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Bladder cancer; PPAR-alpha pathway; Nuclear receptors meta-pathway; Ovarian infertility; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Sphingolipid metabolism in senescence; DYRK1A involvement regarding cell proliferation in brain development; TROP2 regulatory signaling; JAK-STAT signaling in the regulation of beta cells; DNA damage response" "47" "0" "1.031" "0.975" "1.119" "1.060" "1.087" "1.028" "0.994" "1.009" "1.072" "297.6" "306.7" "290.1" "333.1" "315.6" "323.5" "306.1" "295.8" "300.2" "319.0" "" "" "" "" "" "" "" "" "" "" "239.0" "221.3" "230.4" "223.1" "218.3" "242.7" "214.3" "216.0" "300.2" "259.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6058304427516802646" "False" "High" "IsMasterProtein" "Q7Z6J9" "tRNA-splicing endonuclease subunit Sen54 OS=Homo sapiens OX=9606 GN=TSEN54 PE=1 SV=3" "0.000" "False" "26.005" "12" "6" "7" "6" "526" "58.8" "7.91" "18.76" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf12928" "283989" "ENSG00000182173" "TSEN54" "hsa:283989; Q7Z6J9; Q86WV3; Q86XE4; Q8N9H2" "tRNA processing in the nucleus" "" "1" "0" "1.008" "1.009" "1.003" "0.986" "1.003" "0.955" "1.036" "1.041" "0.999" "864.7" "871.4" "872.5" "867.4" "852.5" "867.6" "826.1" "896.2" "899.9" "864.0" "" "" "" "" "" "" "" "" "" "" "694.5" "628.8" "693.1" "581.2" "589.6" "651.0" "578.4" "654.5" "899.9" "702.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2928934229844812076" "False" "High" "IsMasterProtein" "Q8TCD5" "5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2" "0.000" "False" "25.997" "30" "7" "11" "6" "201" "23.4" "6.64" "29.25" "7" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06941" "30833" "ENSG00000125458" "NT5C" "hsa:30833; Q8TCD5; Q96HS6; Q9NP82" "Purine catabolism; Pyrimidine catabolism" "Pyrimidine metabolism" "3" "0" "1.034" "0.995" "1.078" "1.008" "1.000" "1.003" "0.885" "0.944" "0.944" "353.9" "366.1" "352.2" "381.5" "356.8" "354.0" "355.1" "313.2" "334.0" "334.0" "" "" "" "" "" "" "" "" "" "" "284.3" "264.2" "279.7" "255.6" "246.8" "265.6" "248.6" "228.8" "334.0" "271.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6951101032549152638" "False" "High" "IsMasterProtein" "Q9BYD3" "Large ribosomal subunit protein uL4m OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1" "0.000" "False" "25.995" "9" "2" "3" "2" "311" "34.9" "9.72" "16.24" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00573" "51073" "ENSG00000105364" "MRPL4" "A6NNV7; hsa:51073; Q9BW07; Q9BYD3; Q9H4N2; Q9Y317" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.979" "0.995" "0.998" "1.130" "1.052" "1.015" "1.065" "0.996" "0.934" "187.3" "183.4" "186.2" "186.8" "211.6" "196.9" "190.0" "199.3" "186.4" "175.0" "" "" "" "" "" "" "" "" "" "" "150.4" "132.3" "147.9" "125.2" "146.4" "147.8" "133.0" "145.6" "186.4" "142.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338471368414013319" "False" "High" "IsMasterProtein" "Q96T60" "Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens OX=9606 GN=PNKP PE=1 SV=1" "0.000" "False" "25.975" "12" "6" "7" "6" "521" "57.0" "8.46" "20.70" "6" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf08645, Pf13671, Pf17913" "11284" "ENSG00000039650" "PNKP" "hsa:11284; Q96T60; Q9BUL2; Q9P1V2; Q9UKU8; Q9UNF8; Q9UNI0" "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" "Base excision repair; DNA repair pathways, full network" "3" "0" "0.992" "0.988" "1.025" "0.946" "0.999" "0.896" "0.960" "0.988" "0.987" "726.6" "720.7" "717.8" "745.0" "687.1" "726.2" "651.2" "697.9" "718.0" "717.0" "" "" "" "" "" "" "" "" "" "" "583.6" "520.0" "570.2" "499.1" "475.2" "544.9" "455.9" "509.7" "718.0" "583.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119829718007226858" "False" "High" "IsMasterProtein" "Q9UJX5" "Anaphase-promoting complex subunit 4 OS=Homo sapiens OX=9606 GN=ANAPC4 PE=1 SV=2" "0.000" "False" "25.956" "10" "6" "6" "6" "808" "92.1" "5.53" "19.85" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12894, Pf12896" "29945" "ENSG00000053900" "ANAPC4" "A8K8H1; E9PCR4; hsa:29945; Q6PCC6; Q9NSH6; Q9UJX5" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.020" "1.000" "1.035" "1.066" "0.990" "0.955" "1.055" "1.081" "1.079" "352.4" "359.3" "352.3" "364.6" "375.8" "349.0" "336.4" "371.8" "380.9" "380.1" "" "" "" "" "" "" "" "" "" "" "283.0" "259.3" "279.9" "244.3" "259.9" "261.8" "235.5" "271.5" "380.9" "309.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288572419513908439" "False" "High" "IsMasterProtein" "Q8WXG6" "MAP kinase-activating death domain protein OS=Homo sapiens OX=9606 GN=MADD PE=1 SV=2" "0.000" "False" "25.955" "4" "6" "6" "6" "1647" "183.2" "6.04" "20.74" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf02141, Pf03456" "8567" "ENSG00000110514" "MADD" "A8K8S7; B5MEE5; D3DQR4; hsa:8567; O15065; O15293; Q15732; Q15741; Q8IWD7; Q8WXG3; Q8WXG4; Q8WXG5; Q8WXG6; Q8WZ63" "" "Apoptosis modulation and signaling; Deregulation of Rab and Rab effector genes in bladder cancer; TNF-alpha signaling pathway" "3" "0" "1.020" "0.952" "1.127" "1.038" "1.007" "1.119" "1.157" "1.049" "1.031" "442.6" "451.4" "421.5" "499.0" "459.4" "445.9" "495.4" "511.9" "464.1" "456.5" "" "" "" "" "" "" "" "" "" "" "355.5" "325.7" "334.8" "334.3" "317.7" "334.6" "346.9" "373.9" "464.1" "371.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531116507177860716" "False" "High" "IsMasterProtein" "Q06609" "DNA repair protein RAD51 homolog 1 OS=Homo sapiens OX=9606 GN=RAD51 PE=1 SV=1" "0.000" "False" "25.875" "17" "4" "6" "4" "339" "36.9" "5.60" "18.08" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423, Pf14520" "5888" "ENSG00000051180" "RAD51" "B0FXP0; B2R8T6; hsa:5888; Q06609; Q6FHX9; Q6ZNA8; Q9BV60" "Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; Homologous recombination; ATM signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; Breast cancer pathway; Pancreatic adenocarcinoma pathway; DNA repair pathways, full network; Primary ovarian insufficiency; DNA damage response" "23" "0" "1.021" "0.961" "1.033" "0.997" "1.037" "1.080" "1.185" "1.125" "1.051" "549.0" "560.5" "527.8" "567.0" "547.3" "569.4" "593.0" "650.4" "617.4" "576.8" "" "" "" "" "" "" "" "" "" "" "440.9" "404.4" "419.2" "379.9" "378.5" "427.2" "415.2" "475.0" "617.4" "469.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "558828740565352174" "False" "High" "IsMasterProtein" "Q2VPK5" "Cytoplasmic tRNA 2-thiolation protein 2 OS=Homo sapiens OX=9606 GN=CTU2 PE=1 SV=1" "0.000" "False" "25.870" "11" "5" "6" "5" "515" "56.1" "6.32" "19.69" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf10288" "348180" "ENSG00000174177" "CTU2" "B2RXK0; hsa:348180; Q0P511; Q2VPK5; Q66K78; Q6P4C8; Q86SV4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.026" "0.893" "1.033" "0.968" "0.924" "1.021" "0.966" "0.967" "0.944" "440.8" "452.5" "393.5" "455.2" "426.5" "407.4" "450.2" "425.9" "426.4" "416.3" "" "" "" "" "" "" "" "" "" "" "354.1" "326.5" "312.6" "305.0" "295.0" "305.6" "315.2" "311.1" "426.4" "338.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021851569600186030" "False" "High" "IsMasterProtein" "A2A288" "Probable ribonuclease ZC3H12D OS=Homo sapiens OX=9606 GN=ZC3H12D PE=1 SV=3" "0.000" "False" "25.856" "12" "5" "6" "5" "527" "58.0" "8.68" "20.70" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11977, Pf18039" "340152" "ENSG00000178199" "ZC3H12D" "A1L178; A2A288; B2RXF4; B7WNU7; B9ZZP9; B9ZZQ0; hsa:340152; Q6ZRW2" "" "" "0" "0" "0.961" "1.083" "1.100" "1.195" "1.068" "0.924" "1.002" "1.065" "1.073" "95.3" "91.6" "103.2" "104.8" "114.0" "101.8" "88.1" "95.5" "101.5" "102.3" "" "" "" "" "" "" "" "" "" "" "76.6" "66.1" "82.0" "70.2" "78.8" "76.4" "61.7" "69.8" "101.5" "83.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901873737565675382" "False" "High" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "0.000" "False" "25.838" "15" "5" "5" "5" "349" "38.7" "5.78" "16.82" "5" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "1.021" "1.064" "1.020" "1.124" "1.158" "1.066" "1.084" "1.070" "1.103" "438.7" "448.1" "466.6" "447.3" "493.2" "508.1" "467.8" "475.6" "469.3" "483.7" "" "" "" "" "" "" "" "" "" "" "352.3" "323.3" "370.7" "299.7" "341.1" "381.2" "327.5" "347.4" "469.3" "393.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-329240465840991374" "False" "High" "IsMasterProtein" "Q6GMV3" "Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1" "0.000" "False" "25.834" "25" "3" "8" "3" "140" "15.8" "9.10" "28.87" "3" "" "" "other molecular function" "Pf01981" "391356" "ENSG00000184924" "PTRHD1" "Q6GMV3" "" "" "0" "0" "0.945" "0.870" "0.919" "0.905" "0.945" "0.936" "0.875" "0.881" "0.930" "505.5" "477.8" "439.7" "464.4" "457.3" "477.6" "472.9" "442.3" "445.3" "470.3" "" "" "" "" "" "" "" "" "" "" "406.0" "344.8" "349.3" "311.2" "316.3" "358.3" "331.1" "323.0" "445.3" "382.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477032751293866758" "False" "High" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "0.000" "False" "25.806" "26" "5" "6" "5" "247" "27.9" "7.74" "17.04" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "1.156" "1.102" "1.138" "1.044" "0.957" "0.952" "0.999" "1.026" "1.041" "481.1" "556.2" "530.3" "547.7" "502.4" "460.4" "458.1" "480.4" "493.7" "501.0" "" "" "" "" "" "" "" "" "" "" "386.4" "401.4" "421.3" "366.9" "347.5" "345.4" "320.7" "350.9" "493.7" "407.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752338987200815694" "False" "High" "IsMasterProtein" "Q9NQT4" "Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1" "0.000" "False" "25.790" "21" "3" "4" "3" "235" "25.2" "7.59" "19.25" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "56915" "ENSG00000077348" "EXOSC5" "hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "1.052" "1.013" "1.062" "0.985" "1.015" "1.022" "1.023" "0.955" "0.977" "105.4" "110.9" "106.7" "112.0" "103.8" "107.0" "107.7" "107.8" "100.7" "103.0" "" "" "" "" "" "" "" "" "" "" "84.7" "80.0" "84.8" "75.0" "71.8" "80.3" "75.4" "78.7" "100.7" "83.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335320329939268762" "False" "High" "IsMasterProtein" "Q9UBR2" "Cathepsin Z OS=Homo sapiens OX=9606 GN=CTSZ PE=1 SV=1" "0.000" "False" "25.777" "17" "5" "6" "5" "303" "33.8" "7.11" "20.07" "5" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112" "1522" "ENSG00000101160" "CTSZ" "B2RC40; hsa:1522; O75331; Q9UBR2; Q9UQV5; Q9UQV6" "Neutrophil degranulation; COPII-mediated vesicle transport; Cargo concentration in the ER; Lysosome Vesicle Biogenesis; Metabolism of Angiotensinogen to Angiotensins" "" "5" "0" "0.951" "1.018" "0.891" "0.929" "0.888" "0.879" "0.958" "0.968" "0.919" "785.2" "746.5" "799.7" "699.9" "729.8" "697.6" "689.9" "751.9" "759.7" "721.5" "" "" "" "" "" "" "" "" "" "" "630.7" "538.6" "635.2" "468.9" "504.8" "523.4" "483.0" "549.1" "759.7" "586.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1962544655148758053" "False" "High" "IsMasterProtein" "P35240" "Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1" "0.000" "False" "25.765" "11" "7" "7" "7" "595" "69.6" "6.47" "22.96" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4771" "ENSG00000186575" "NF2" "hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4" "Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs" "Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma" "10" "0" "0.964" "0.972" "0.886" "0.975" "0.979" "1.002" "1.017" "1.050" "1.001" "657.9" "634.2" "639.3" "583.0" "641.2" "644.2" "659.2" "669.3" "691.0" "658.7" "" "" "" "" "" "" "" "" "" "" "528.4" "457.6" "507.8" "390.6" "443.5" "483.3" "461.5" "488.8" "691.0" "535.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3729688095668830132" "False" "High" "IsMasterProtein" "O75419" "Cell division control protein 45 homolog OS=Homo sapiens OX=9606 GN=CDC45 PE=1 SV=1" "0.000" "False" "25.757" "12" "6" "7" "6" "566" "65.5" "5.53" "22.20" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02724" "8318" "ENSG00000093009" "CDC45" "B4DDB4; B4DDU3; E9PDH7; hsa:8318; O60856; O75419; Q20WK8; Q6UW54; Q9UP68" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription" "Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication" "9" "0" "1.081" "1.056" "1.124" "1.012" "1.071" "1.143" "1.286" "1.202" "1.092" "135.7" "146.7" "143.3" "152.5" "137.3" "145.3" "155.1" "174.4" "163.1" "148.1" "" "" "" "" "" "" "" "" "" "" "109.0" "105.9" "113.9" "102.2" "95.0" "109.0" "108.6" "127.4" "163.1" "120.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4336688759083416299" "False" "High" "IsMasterProtein" "Q15813" "Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1" "0.000" "False" "25.744" "13" "7" "7" "6" "527" "59.3" "6.76" "25.22" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf14560" "6905" "ENSG00000284770" "TBCE" "A8K8C2; B7Z3P1; Q15813" "Post-chaperonin tubulin folding pathway" "" "1" "0" "1.037" "0.973" "1.034" "0.979" "0.987" "1.064" "0.981" "1.037" "1.003" "543.0" "563.3" "528.5" "561.3" "531.4" "536.0" "577.5" "532.7" "562.8" "544.8" "" "" "" "" "" "" "" "" "" "" "436.1" "406.5" "419.8" "376.1" "367.5" "402.1" "404.3" "389.0" "562.8" "443.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1391272447933749932" "False" "High" "IsMasterProtein" "Q9UNI6" "Dual specificity protein phosphatase 12 OS=Homo sapiens OX=9606 GN=DUSP12 PE=1 SV=1" "0.000" "False" "25.742" "25" "6" "7" "6" "340" "37.7" "6.84" "18.87" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00782" "11266" "ENSG00000081721" "DUSP12" "hsa:11266; Q5VXA8; Q9UNI6" "" "" "0" "0" "1.250" "1.077" "1.147" "1.196" "1.153" "1.240" "1.010" "1.213" "1.168" "260.8" "325.9" "280.8" "299.0" "311.9" "300.6" "323.4" "263.4" "316.4" "304.6" "" "" "" "" "" "" "" "" "" "" "209.5" "235.2" "223.1" "200.4" "215.7" "225.6" "226.4" "192.4" "316.4" "247.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7482655995969634953" "False" "High" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "0.000" "False" "25.742" "27" "3" "9" "3" "131" "13.8" "9.77" "24.48" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "1.042" "1.100" "1.042" "1.011" "1.067" "1.223" "1.066" "1.067" "0.975" "363.5" "378.6" "399.9" "378.6" "367.3" "387.8" "444.4" "387.3" "387.8" "354.5" "" "" "" "" "" "" "" "" "" "" "291.9" "273.2" "317.7" "253.7" "254.0" "291.0" "311.2" "282.9" "387.8" "288.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145524999594346517" "False" "High" "IsMasterProtein" "O60518" "Ran-binding protein 6 OS=Homo sapiens OX=9606 GN=RANBP6 PE=1 SV=2" "0.000" "False" "25.738" "5" "4" "8" "2" "1105" "124.6" "5.01" "24.21" "4" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf13513, Pf18808, Pf18829" "26953" "ENSG00000137040" "RANBP6" "hsa:26953; O60518; Q5T7X4; Q7Z3V2; Q96E78" "" "" "0" "0" "1.047" "1.107" "1.124" "1.030" "0.933" "1.139" "0.990" "0.968" "1.025" "334.8" "350.7" "370.7" "376.3" "345.0" "312.3" "381.5" "331.5" "324.2" "343.1" "" "" "" "" "" "" "" "" "" "" "268.9" "253.1" "294.5" "252.1" "238.6" "234.3" "267.1" "242.1" "324.2" "279.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4778122268276291111" "False" "High" "IsMasterProtein" "P49406" "Large ribosomal subunit protein bL19m OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" "0.000" "False" "25.735" "17" "6" "8" "6" "292" "33.5" "9.50" "29.17" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01245" "9801" "ENSG00000115364" "MRPL19" "hsa:9801; P49406; Q53TX9; Q96Q52" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Cytoplasmic ribosomal proteins" "4" "0" "0.978" "0.993" "0.954" "0.997" "0.984" "0.919" "0.921" "1.015" "0.950" "1017.3" "995.0" "1010.1" "970.5" "1014.3" "1000.7" "935.2" "936.7" "1032.8" "966.2" "" "" "" "" "" "" "" "" "" "" "817.1" "717.9" "802.4" "650.3" "701.5" "750.8" "654.8" "684.1" "1032.8" "785.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163626551938173047" "False" "High" "IsMasterProtein" "P27987" "Inositol-trisphosphate 3-kinase B OS=Homo sapiens OX=9606 GN=ITPKB PE=1 SV=5" "0.000" "False" "25.735" "10" "7" "8" "7" "946" "102.3" "8.43" "24.28" "7" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "3707" "ENSG00000143772" "ITPKB" "hsa:3707; P27987; Q5VWL9; Q5VWM0; Q96BZ2; Q96JS1; Q9UH47" "Synthesis of IP3 and IP4 in the cytosol" "CCL18 signaling pathway" "2" "0" "1.100" "1.029" "1.031" "1.207" "1.067" "1.058" "1.152" "0.972" "1.078" "293.2" "322.6" "301.6" "302.4" "353.8" "312.7" "310.1" "337.8" "285.0" "316.2" "" "" "" "" "" "" "" "" "" "" "235.5" "232.8" "239.6" "202.6" "244.7" "234.6" "217.1" "246.7" "285.0" "257.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5959854138225624200" "False" "High" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "0.000" "False" "25.726" "4" "6" "6" "6" "1792" "201.4" "9.64" "20.19" "6" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "Antigen processing: Ubiquitination & Proteasome degradation; RHOBTB1 GTPase cycle" "" "2" "0" "1.024" "1.047" "1.001" "1.070" "1.059" "1.012" "1.138" "1.128" "1.031" "224.7" "230.0" "235.2" "225.0" "240.5" "237.9" "227.5" "255.6" "253.5" "231.6" "" "" "" "" "" "" "" "" "" "" "180.5" "166.0" "186.8" "150.7" "166.4" "178.5" "159.3" "186.7" "253.5" "188.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4995035234308884546" "False" "High" "IsMasterProtein" "Q9Y6B6" "Small COPII coat GTPase SAR1B OS=Homo sapiens OX=9606 GN=SAR1B PE=1 SV=1" "0.000" "False" "25.701" "20" "4" "8" "1" "198" "22.4" "6.11" "22.41" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00025" "51128" "ENSG00000152700" "SAR1B" "D3DQA4; hsa:51128; Q567T4; Q9Y6B6" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Chylomicron assembly" "Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism; Enterocyte cholesterol metabolism" "10" "0" "1.019" "1.021" "0.902" "0.914" "0.991" "0.705" "1.029" "0.981" "0.982" "162.1" "165.2" "165.5" "146.1" "148.1" "160.7" "114.3" "166.7" "158.9" "159.1" "" "" "" "" "" "" "" "" "" "" "130.2" "119.2" "131.5" "97.9" "102.4" "120.5" "80.0" "121.8" "158.9" "129.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-567080843799231126" "False" "High" "IsMasterProtein" "Q9NVF7" "F-box only protein 28 OS=Homo sapiens OX=9606 GN=FBXO28 PE=1 SV=1" "0.000" "False" "25.700" "14" "3" "4" "3" "368" "41.1" "9.55" "19.74" "3" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00646" "23219" "ENSG00000143756" "FBXO28" "E9PEM8; hsa:23219; O75070; Q9NVF7" "" "" "0" "0" "1.121" "1.044" "1.267" "1.115" "1.187" "0.985" "0.984" "1.012" "1.102" "133.9" "150.1" "139.8" "169.7" "149.3" "159.0" "131.9" "131.7" "135.6" "147.6" "" "" "" "" "" "" "" "" "" "" "107.5" "108.3" "111.0" "113.7" "103.2" "119.3" "92.4" "96.2" "135.6" "120.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876256361286906855" "False" "High" "IsMasterProtein" "P62269" "Small ribosomal subunit protein uS13 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "0.000" "False" "25.678" "39" "8" "9" "8" "152" "17.7" "10.99" "26.18" "8" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.930" "1.105" "1.166" "1.162" "1.105" "1.148" "1.221" "1.157" "1.128" "521.0" "484.6" "575.8" "607.6" "605.6" "575.9" "598.2" "636.3" "603.0" "587.6" "" "" "" "" "" "" "" "" "" "" "418.5" "349.7" "457.4" "407.1" "418.8" "432.1" "418.8" "464.7" "603.0" "477.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8263646129409186084" "False" "High" "IsMasterProtein" "Q14814" "Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1" "0.000" "False" "25.658" "13" "7" "9" "5" "521" "55.9" "7.88" "25.22" "7" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4209" "ENSG00000116604; ENSG00000291761" "MEF2D" "D3DVC0; hsa:4209; Q14814; Q14815; Q5T9U5; Q5T9U6" "NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "18" "2" "1.072" "1.021" "1.059" "1.072" "1.021" "0.989" "1.008" "0.990" "1.063" "477.8" "512.4" "487.8" "506.1" "512.3" "488.0" "472.4" "481.8" "473.2" "507.9" "" "" "" "" "" "" "" "" "" "" "383.8" "369.7" "387.5" "339.1" "354.3" "366.1" "330.7" "351.8" "473.2" "413.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3251475669442544967" "False" "High" "IsMasterProtein" "Q9P270" "SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2" "0.000" "False" "25.629" "14" "4" "5" "4" "581" "62.5" "9.45" "18.52" "4" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15301" "57606" "ENSG00000109171" "SLAIN2" "A8K4P1; hsa:57606; Q8N5R3; Q9P270" "" "" "0" "0" "1.176" "1.042" "1.200" "1.246" "1.106" "1.140" "1.158" "1.078" "1.218" "209.6" "246.6" "218.3" "251.5" "261.2" "231.9" "238.9" "242.7" "225.9" "255.3" "" "" "" "" "" "" "" "" "" "" "168.4" "178.0" "173.4" "168.5" "180.6" "174.0" "167.3" "177.3" "225.9" "207.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7215456536450440199" "False" "High" "IsMasterProtein" "Q9H0U9" "Testis-specific Y-encoded-like protein 1 OS=Homo sapiens OX=9606 GN=TSPYL1 PE=1 SV=3" "0.000" "False" "25.610" "7" "3" "4" "3" "437" "49.2" "5.45" "18.48" "3" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "7259" "ENSG00000189241" "TSPYL1" "hsa:7259; O75885; Q5TFE6; Q9H0U9" "" "Sudden infant death syndrome (SIDS) susceptibility pathways" "1" "0" "1.039" "0.984" "1.125" "1.057" "1.002" "1.131" "1.134" "1.075" "1.038" "322.1" "334.8" "317.0" "362.5" "340.5" "322.8" "364.4" "365.4" "346.2" "334.3" "" "" "" "" "" "" "" "" "" "" "258.7" "241.5" "251.8" "242.9" "235.5" "242.2" "255.1" "266.9" "346.2" "271.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6512701136026714686" "False" "High" "IsMasterProtein" "O95379" "Tumor necrosis factor alpha-induced protein 8 OS=Homo sapiens OX=9606 GN=TNFAIP8 PE=1 SV=1" "0.000" "False" "25.580" "21" "4" "9" "4" "198" "23.0" "7.93" "30.07" "4" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05527" "25816" "ENSG00000145779" "TNFAIP8" "B3KMH1; B3KMI2; B7Z713; hsa:25816; O95379; Q9P1Q1; Q9UER5; Q9UP47" "PI Metabolism" "" "1" "0" "0.982" "1.011" "0.925" "0.985" "1.009" "0.983" "0.968" "0.966" "0.997" "613.1" "601.8" "619.8" "567.2" "604.1" "618.9" "602.8" "593.8" "592.3" "611.4" "" "" "" "" "" "" "" "" "" "" "492.4" "434.2" "492.3" "380.1" "417.8" "464.3" "422.1" "433.6" "592.3" "497.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6450770185944886404" "False" "High" "IsMasterProtein" "Q504Q3" "PAN2-PAN3 deadenylation complex catalytic subunit PAN2 OS=Homo sapiens OX=9606 GN=PAN2 PE=1 SV=3" "0.000" "False" "25.579" "6" "6" "8" "6" "1202" "135.3" "5.99" "23.36" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929, Pf13423, Pf20770" "9924" "ENSG00000135473" "PAN2" "hsa:9924; O75189; Q504Q3; Q76E12; Q8IVE1" "Deadenylation of mRNA" "Ectoderm differentiation; Ectoderm differentiation" "3" "0" "1.025" "0.952" "1.140" "1.126" "1.154" "0.955" "1.099" "1.024" "0.987" "236.2" "242.1" "224.8" "269.3" "265.9" "272.6" "225.5" "259.7" "241.8" "233.2" "" "" "" "" "" "" "" "" "" "" "189.7" "174.7" "178.6" "180.4" "183.9" "204.5" "157.9" "189.7" "241.8" "189.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5240696879354608925" "False" "High" "IsMasterProtein" "Q8IUF1" "Zinc-regulated GTPase metalloprotein activator 1B OS=Homo sapiens OX=9606 GN=ZNG1B PE=1 SV=1" "0.000" "False" "25.561" "15" "5" "6" "5" "395" "44.0" "4.89" "18.80" "5" "" "nucleus;other cell component" "other molecular function" "Pf02492, Pf07683" "150472" "ENSG00000136682" "ZNG1B" "hsa:150472; Q0VAN3; Q8IUF1" "" "" "0" "0" "0.971" "1.022" "1.134" "1.058" "1.078" "1.066" "1.016" "0.902" "1.022" "347.0" "336.7" "354.6" "393.6" "367.2" "373.9" "369.8" "352.4" "312.9" "354.7" "" "" "" "" "" "" "" "" "" "" "278.7" "243.0" "281.7" "263.7" "254.0" "280.5" "258.9" "257.4" "312.9" "288.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8309198551146026693" "False" "High" "IsMasterProtein" "O15226" "NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2" "0.000" "False" "25.559" "9" "7" "7" "7" "690" "77.6" "8.79" "24.69" "7" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01424, Pf01585" "55922" "ENSG00000186416" "NKRF" "G3V1N1; O15226; Q4VC41; Q9UJ91" "" "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "2" "0" "0.957" "1.016" "0.924" "0.846" "1.025" "0.699" "0.979" "0.986" "0.989" "67.1" "64.2" "68.1" "62.0" "56.8" "68.8" "46.9" "65.7" "66.1" "66.4" "" "" "" "" "" "" "" "" "" "" "53.9" "46.4" "54.1" "41.5" "39.3" "51.6" "32.8" "47.9" "66.1" "54.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295020939105715533" "False" "High" "IsMasterProtein" "Q9NRS6" "Sorting nexin-15 OS=Homo sapiens OX=9606 GN=SNX15 PE=1 SV=1" "0.000" "False" "25.538" "23" "6" "7" "6" "342" "38.3" "5.19" "25.55" "6" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00787, Pf04212" "29907" "ENSG00000110025" "SNX15" "E5KQS6; hsa:29907; Q9NRS5; Q9NRS6" "" "" "0" "0" "0.947" "1.094" "1.071" "0.927" "0.999" "0.947" "0.818" "0.961" "0.948" "67.2" "63.7" "73.5" "72.0" "62.3" "67.1" "63.6" "55.0" "64.6" "63.7" "" "" "" "" "" "" "" "" "" "" "54.0" "45.9" "58.4" "48.2" "43.1" "50.4" "44.5" "40.2" "64.6" "51.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8120916206400470693" "False" "High" "IsMasterProtein" "O96006" "E3 SUMO-protein ligase ZBED1 OS=Homo sapiens OX=9606 GN=ZBED1 PE=1 SV=1" "0.000" "False" "25.523" "9" "5" "6" "5" "694" "78.1" "6.10" "21.41" "5" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892, Pf05699" "9189" "ENSG00000214717; ENSG00000292345" "ZBED1" "hsa:9189; O96006; Q96BY4" "SUMOylation of chromatin organization proteins" "" "1" "0" "1.080" "1.023" "1.083" "1.219" "1.066" "0.985" "1.219" "1.293" "1.180" "107.8" "116.3" "110.2" "116.7" "131.3" "114.8" "106.2" "131.3" "139.4" "127.1" "" "" "" "" "" "" "" "" "" "" "86.6" "83.9" "87.6" "78.2" "90.8" "86.2" "74.3" "95.9" "139.4" "103.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500960934407520232" "False" "High" "IsMasterProtein" "O43716" "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1" "0.000" "False" "25.466" "47" "5" "7" "5" "136" "15.1" "5.05" "24.29" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf02686" "283459" "ENSG00000257218" "GATC" "B3KSU7; hsa:283459; O43716; Q3B824; Q3KNR8" "" "" "0" "0" "1.043" "1.010" "1.077" "1.163" "0.976" "1.032" "1.011" "1.048" "1.101" "290.3" "302.9" "293.2" "312.6" "337.5" "283.4" "299.6" "293.6" "304.1" "319.5" "" "" "" "" "" "" "" "" "" "" "233.2" "218.6" "232.9" "209.5" "233.4" "212.6" "209.8" "214.4" "304.1" "259.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "652466818170242457" "False" "High" "IsMasterProtein" "Q9H993" "Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1" "0.000" "False" "25.451" "10" "5" "10" "5" "441" "51.1" "5.76" "39.95" "5" "other metabolic processes;stress response" "" "other molecular function" "Pf01937" "79624" "ENSG00000146476" "ARMT1" "hsa:79624; Q96FC6; Q9H993; Q9UFY5" "" "" "0" "0" "0.928" "0.991" "0.937" "0.920" "0.924" "0.903" "0.935" "0.874" "0.932" "1596.9" "1481.1" "1581.8" "1497.0" "1469.1" "1476.0" "1441.9" "1492.4" "1396.4" "1488.9" "" "" "" "" "" "" "" "" "" "" "1282.6" "1068.8" "1256.5" "1003.0" "1016.0" "1107.4" "1009.6" "1089.9" "1396.4" "1210.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1844756928667547842" "False" "High" "IsMasterProtein" "Q9NWU1" "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1" "0.000" "False" "25.448" "9" "3" "4" "3" "459" "48.8" "7.66" "14.65" "3" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00109, Pf02801" "54995" "ENSG00000151093" "OXSM" "Q9NWU1" "Mitochondrial protein degradation" "Mitochondrial fatty acid synthesis pathway" "2" "0" "1.057" "0.952" "1.002" "0.977" "1.004" "0.966" "0.877" "0.899" "0.923" "387.5" "409.4" "369.0" "388.4" "378.4" "388.8" "374.5" "339.9" "348.4" "357.6" "" "" "" "" "" "" "" "" "" "" "311.2" "295.4" "293.1" "260.2" "261.7" "291.7" "262.2" "248.3" "348.4" "290.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4776370304497058949" "False" "High" "IsMasterProtein" "Q8IV04" "Carabin OS=Homo sapiens OX=9606 GN=TBC1D10C PE=1 SV=1" "0.000" "False" "25.382" "8" "3" "4" "3" "446" "49.7" "8.76" "14.46" "3" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "374403" "ENSG00000175463" "TBC1D10C" "G3V1D6; hsa:374403; Q8IV04" "Neutrophil degranulation; TBC/RABGAPs" "" "2" "0" "1.117" "0.953" "1.138" "1.087" "1.003" "1.013" "1.051" "1.007" "1.042" "171.7" "191.8" "163.6" "195.4" "186.7" "172.3" "174.0" "180.4" "173.0" "178.9" "" "" "" "" "" "" "" "" "" "" "137.9" "138.4" "130.0" "130.9" "129.1" "129.3" "121.8" "131.8" "173.0" "145.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5248794698895072137" "False" "High" "IsMasterProtein" "Q9NVC6" "Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2" "0.000" "False" "25.357" "11" "7" "8" "7" "651" "72.8" "7.44" "23.32" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10156" "9440" "ENSG00000042429" "MED17" "B3KN07; hsa:9440; Q9HA81; Q9NVC6; Q9UNP7; Q9Y2W0; Q9Y660" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "0.990" "0.958" "0.985" "0.965" "0.984" "0.958" "0.967" "0.947" "0.944" "1300.4" "1287.9" "1246.3" "1280.8" "1255.4" "1279.4" "1245.6" "1257.3" "1231.8" "1227.7" "" "" "" "" "" "" "" "" "" "" "1044.5" "929.3" "990.0" "858.1" "868.2" "959.9" "872.1" "918.2" "1231.8" "998.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1411281452547832793" "False" "High" "IsMasterProtein" "Q9UPT9" "Ubiquitin carboxyl-terminal hydrolase 22 OS=Homo sapiens OX=9606 GN=USP22 PE=1 SV=2" "0.000" "False" "25.347" "12" "6" "7" "6" "525" "59.9" "8.05" "20.20" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00443, Pf02148" "23326" "ENSG00000124422" "USP22" "A0JNS3; hsa:23326; Q2NLE2; Q6MZY4; Q8TBS8; Q96IW5; Q9UPT9" "Ub-specific processing proteases; HATs acetylate histones" "" "2" "0" "1.027" "0.986" "1.029" "1.005" "0.973" "0.942" "0.981" "0.991" "0.994" "388.3" "398.9" "382.9" "399.8" "390.4" "377.8" "366.0" "380.9" "384.8" "385.9" "" "" "" "" "" "" "" "" "" "" "311.9" "287.8" "304.2" "267.8" "270.0" "283.5" "256.3" "278.2" "384.8" "313.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1581896134396951467" "False" "High" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "0.000" "False" "25.315" "18" "3" "6" "3" "195" "19.5" "4.67" "26.68" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "0.974" "0.970" "0.961" "1.051" "1.014" "1.114" "0.977" "1.022" "0.990" "757.8" "737.9" "734.9" "728.5" "796.3" "768.7" "844.0" "740.2" "774.5" "750.4" "" "" "" "" "" "" "" "" "" "" "608.7" "532.5" "583.7" "488.1" "550.8" "576.7" "590.9" "540.6" "774.5" "610.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3071770870623054181" "False" "High" "IsMasterProtein" "Q8N442" "Translation factor GUF1, mitochondrial OS=Homo sapiens OX=9606 GN=GUF1 PE=1 SV=1" "0.000" "False" "25.308" "10" "6" "8" "6" "669" "74.3" "8.59" "23.49" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion" "translation activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf06421" "60558" "ENSG00000151806" "GUF1" "hsa:60558; Q5XKM8; Q8N442; Q9H710; Q9H8U4" "" "" "0" "0" "1.143" "0.933" "0.976" "0.984" "0.980" "0.988" "0.869" "0.980" "1.030" "383.6" "438.4" "357.9" "374.4" "377.6" "375.9" "378.9" "333.5" "375.9" "395.2" "" "" "" "" "" "" "" "" "" "" "308.1" "316.3" "284.3" "250.9" "261.1" "282.0" "265.3" "243.6" "375.9" "321.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8492559823843858039" "False" "High" "IsMasterProtein" "Q6ZW49" "PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2" "0.000" "False" "25.307" "7" "5" "6" "5" "1069" "121.3" "6.70" "22.10" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf00533, Pf12738, Pf16589" "22976" "ENSG00000157212" "PAXIP1" "hsa:22976; O15404; Q6N099; Q6ZW49; Q6ZWH9; Q7Z315; Q86UN0; Q8N4P9; Q96HP2" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nonhomologous End-Joining (NHEJ)" "16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Kleefstra syndrome" "6" "0" "1.104" "1.150" "1.038" "1.018" "1.066" "0.949" "1.020" "1.225" "1.075" "79.8" "88.1" "91.8" "82.8" "81.2" "85.0" "75.7" "81.4" "97.7" "85.8" "" "" "" "" "" "" "" "" "" "" "64.1" "63.6" "72.9" "55.5" "56.2" "63.8" "53.0" "59.4" "97.7" "69.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6559218798370917350" "False" "High" "IsMasterProtein" "Q6ZUT9" "DENN domain-containing protein 5B OS=Homo sapiens OX=9606 GN=DENND5B PE=1 SV=2" "0.000" "False" "25.300" "6" "7" "7" "7" "1274" "144.9" "6.73" "23.85" "7" "other biological processes" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf01477, Pf02141, Pf02759, Pf03455, Pf03456" "160518" "ENSG00000170456" "DENND5B" "B5ME75; hsa:160518; Q59FW8; Q68CZ7; Q6NUJ0; Q6ZUT9; Q7Z3F9; Q8N973; Q8WUC8" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.163" "1.013" "1.174" "1.160" "1.056" "1.077" "1.104" "1.094" "1.086" "549.6" "638.9" "557.0" "645.3" "637.3" "580.6" "592.0" "606.5" "601.4" "596.8" "" "" "" "" "" "" "" "" "" "" "441.4" "461.0" "442.4" "432.3" "440.7" "435.6" "414.5" "442.9" "601.4" "485.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492366251309725518" "False" "High" "IsMasterProtein" "Q9BZ23" "Pantothenate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PANK2 PE=1 SV=3" "0.000" "False" "25.292" "9" "4" "6" "2" "570" "62.6" "9.28" "23.04" "4" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf03630" "80025" "ENSG00000125779" "PANK2" "B1AK33; B2Z3X0; D3DVZ0; hsa:80025; Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9BZ23; Q9HAF2" "Coenzyme A biosynthesis" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "3" "0" "1.231" "1.192" "1.323" "1.154" "1.217" "1.155" "1.051" "1.208" "1.220" "72.0" "88.6" "85.8" "95.2" "83.1" "87.6" "83.1" "75.6" "87.0" "87.8" "" "" "" "" "" "" "" "" "" "" "57.8" "63.9" "68.2" "63.8" "57.5" "65.7" "58.2" "55.2" "87.0" "71.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3244624518097785869" "False" "High" "IsMasterProtein" "Q676U5" "Autophagy-related protein 16-1 OS=Homo sapiens OX=9606 GN=ATG16L1 PE=1 SV=2" "0.000" "False" "25.269" "11" "7" "7" "7" "607" "68.2" "6.64" "24.81" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf08614" "55054" "ENSG00000085978; ENSG00000281089" "ATG16L1" "A3EXK9; A3EXL0; B6ZDH0; hsa:55054; Q676U5; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619" "Macroautophagy" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "8" "0" "1.027" "0.919" "1.068" "1.003" "1.040" "1.004" "0.950" "0.979" "0.990" "693.1" "712.2" "637.0" "740.0" "695.3" "721.0" "695.8" "658.3" "678.6" "686.0" "" "" "" "" "" "" "" "" "" "" "556.7" "513.9" "506.0" "495.8" "480.8" "540.9" "487.2" "480.8" "678.6" "557.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3854455294821174963" "False" "High" "IsMasterProtein" "Q969X6" "U3 small nucleolar RNA-associated protein 4 homolog OS=Homo sapiens OX=9606 GN=UTP4 PE=1 SV=1" "0.000" "False" "25.253" "9" "6" "6" "6" "686" "76.8" "8.85" "20.12" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "84916" "ENSG00000141076; ENSG00000262788" "UTP4" "hsa:84916; Q8NCD9; Q8TF14; Q969X6; Q96SP0; Q96SR9; Q96SZ9; Q96T13; Q9BWK6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.009" "1.089" "1.050" "1.007" "1.005" "0.983" "0.988" "0.981" "1.029" "246.7" "248.8" "268.6" "259.0" "248.3" "247.9" "242.5" "243.7" "242.0" "253.7" "" "" "" "" "" "" "" "" "" "" "198.1" "179.5" "213.3" "173.5" "171.7" "186.0" "169.8" "178.0" "242.0" "206.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2486972886246464504" "False" "High" "IsMasterProtein" "O00221" "NF-kappa-B inhibitor epsilon OS=Homo sapiens OX=9606 GN=NFKBIE PE=1 SV=3" "0.000" "False" "25.249" "15" "5" "6" "5" "500" "52.8" "6.68" "22.74" "5" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00023" "4794" "ENSG00000146232" "NFKBIE" "hsa:4794; O00221; Q5T9V9" "Activation of NF-kappaB in B cells" "TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19" "7" "0" "1.030" "0.983" "1.091" "1.135" "0.973" "1.107" "1.087" "1.051" "1.096" "623.1" "642.0" "612.5" "679.7" "707.3" "606.4" "689.8" "677.1" "655.0" "682.7" "" "" "" "" "" "" "" "" "" "" "500.5" "463.3" "486.6" "455.4" "489.2" "455.0" "482.9" "494.5" "655.0" "555.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4597913287802266182" "False" "High" "IsMasterProtein" "O60921" "Checkpoint protein HUS1 OS=Homo sapiens OX=9606 GN=HUS1 PE=1 SV=1" "0.000" "False" "25.206" "25" "6" "6" "6" "280" "31.7" "6.84" "19.13" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04005" "3364" "ENSG00000136273" "HUS1" "B4DFI9; hsa:3364; O60921" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "ATR signaling" "8" "0" "0.998" "1.103" "1.037" "1.048" "1.036" "0.985" "0.983" "0.965" "1.056" "219.5" "219.1" "242.0" "227.5" "230.0" "227.3" "216.1" "215.8" "211.7" "231.7" "" "" "" "" "" "" "" "" "" "" "176.3" "158.1" "192.2" "152.4" "159.0" "170.5" "151.3" "157.6" "211.7" "188.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6971851119340033318" "False" "High" "IsMasterProtein" "Q712K3" "Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1" "0.000" "False" "25.172" "21" "5" "6" "4" "238" "27.1" "4.42" "20.33" "5" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "54926" "ENSG00000107341" "UBE2R2" "D3DRL5; hsa:54926; Q712K3; Q9NX64" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "" "2" "0" "0.925" "1.013" "0.973" "0.951" "0.998" "0.889" "0.902" "0.984" "0.948" "453.5" "419.3" "459.5" "441.4" "431.1" "452.6" "403.3" "408.9" "446.0" "429.7" "" "" "" "" "" "" "" "" "" "" "364.2" "302.6" "365.0" "295.7" "298.2" "339.6" "282.4" "298.7" "446.0" "349.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660438545085976361" "False" "High" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "0.000" "False" "25.158" "13" "4" "4" "4" "403" "43.8" "5.78" "16.47" "4" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13831" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "0.988" "1.016" "1.108" "0.990" "1.026" "1.110" "1.058" "0.984" "0.999" "448.0" "442.5" "455.1" "496.5" "443.4" "459.9" "497.1" "474.1" "440.7" "447.8" "" "" "" "" "" "" "" "" "" "" "359.9" "319.3" "361.5" "332.6" "306.7" "345.0" "348.1" "346.2" "440.7" "364.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7112262159952005485" "False" "High" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "0.000" "False" "25.148" "12" "4" "7" "4" "356" "38.1" "9.83" "23.99" "4" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "1.098" "1.048" "1.245" "1.251" "1.085" "1.110" "1.155" "1.107" "1.197" "325.1" "357.0" "340.5" "404.7" "406.6" "352.5" "360.8" "375.4" "359.9" "389.0" "" "" "" "" "" "" "" "" "" "" "261.1" "257.6" "270.5" "271.1" "281.2" "264.5" "252.6" "274.1" "359.9" "316.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3742199827484990276" "False" "High" "IsMasterProtein" "P53667" "LIM domain kinase 1 OS=Homo sapiens OX=9606 GN=LIMK1 PE=1 SV=3" "0.000" "False" "25.145" "8" "5" "6" "5" "647" "72.5" "6.98" "19.72" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00412, Pf00595, Pf07714" "3984" "ENSG00000106683" "LIMK1" "B7Z6I8; D3DXF4; D3DXF5; hsa:3984; O15283; P53667; Q15820; Q15821; Q75MU3; Q9Y5Q1" "Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Microtubule cytoskeleton regulation; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "12" "0" "1.054" "1.067" "1.057" "1.047" "1.047" "0.985" "1.036" "1.036" "1.017" "195.5" "206.1" "208.5" "206.6" "204.7" "204.7" "192.6" "202.5" "202.5" "198.8" "" "" "" "" "" "" "" "" "" "" "157.0" "148.7" "165.6" "138.4" "141.6" "153.6" "134.9" "147.9" "202.5" "161.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065211085214910630" "False" "High" "IsMasterProtein" "Q96EL3" "Large ribosomal subunit protein mL53 OS=Homo sapiens OX=9606 GN=MRPL53 PE=1 SV=1" "0.000" "False" "25.137" "49" "4" "5" "4" "112" "12.1" "8.76" "19.28" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10780" "116540" "ENSG00000204822" "MRPL53" "hsa:116540; Q96EL3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.119" "1.008" "1.077" "1.109" "1.138" "1.123" "1.100" "1.052" "1.018" "670.8" "750.7" "676.1" "722.8" "743.8" "763.3" "753.2" "738.2" "705.4" "682.7" "" "" "" "" "" "" "" "" "" "" "538.8" "541.7" "537.0" "484.2" "514.4" "572.7" "527.4" "539.1" "705.4" "555.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2583602978446666213" "False" "High" "IsMasterProtein" "O15514" "DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1" "0.000" "False" "25.130" "56" "5" "6" "5" "142" "16.3" "4.79" "16.88" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf03874" "5433" "ENSG00000144231" "POLR2D" "hsa:5433; O15514; Q52LT4" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism" "42" "0" "1.032" "1.006" "1.135" "1.014" "0.992" "1.146" "1.111" "1.184" "1.109" "245.1" "253.0" "246.6" "278.2" "248.6" "243.2" "280.8" "272.2" "290.2" "271.8" "" "" "" "" "" "" "" "" "" "" "196.8" "182.6" "195.9" "186.4" "171.9" "182.5" "196.6" "198.8" "290.2" "221.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049442156646566229" "False" "High" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "0.000" "False" "25.129" "23" "8" "10" "8" "313" "35.1" "7.69" "30.54" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "1.065" "1.092" "1.011" "1.018" "0.998" "0.946" "1.037" "0.955" "1.023" "686.4" "731.3" "749.3" "694.1" "698.8" "684.8" "649.4" "711.7" "655.5" "701.9" "" "" "" "" "" "" "" "" "" "" "551.3" "527.7" "595.2" "465.1" "483.3" "513.8" "454.7" "519.7" "655.5" "570.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8979611846707191829" "False" "High" "IsMasterProtein" "O76080" "AN1-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=ZFAND5 PE=1 SV=1" "0.000" "False" "25.118" "27" "4" "7" "4" "213" "23.1" "8.51" "19.24" "4" "developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "7763" "ENSG00000107372" "ZFAND5" "A8K484; hsa:7763; O76080" "" "" "0" "0" "1.193" "1.058" "1.063" "1.144" "1.108" "1.183" "1.250" "1.140" "1.143" "397.1" "473.8" "420.1" "422.0" "454.2" "440.1" "469.9" "496.2" "452.7" "453.8" "" "" "" "" "" "" "" "" "" "" "318.9" "341.9" "333.7" "282.8" "314.1" "330.2" "329.0" "362.4" "452.7" "369.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3857525489381916364" "False" "High" "IsMasterProtein" "A8MXV4" "Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1" "0.000" "False" "25.112" "11" "3" "4" "3" "375" "42.2" "7.64" "16.95" "3" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "" "390916" "ENSG00000213965" "NUDT19" "A8MXV4; hsa:390916" "Peroxisomal lipid metabolism; Peroxisomal protein import" "" "2" "0" "1.060" "1.124" "1.151" "1.134" "0.940" "1.083" "0.998" "1.078" "1.016" "50.8" "53.9" "57.1" "58.5" "57.6" "47.8" "55.0" "50.7" "54.8" "51.6" "" "" "" "" "" "" "" "" "" "" "40.8" "38.9" "45.4" "39.2" "39.8" "35.8" "38.5" "37.0" "54.8" "42.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2435727542331039410" "False" "High" "IsMasterProtein" "O00522" "Krev interaction trapped protein 1 OS=Homo sapiens OX=9606 GN=KRIT1 PE=1 SV=2" "0.000" "False" "25.088" "8" "5" "5" "5" "736" "84.3" "8.41" "18.93" "5" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00023, Pf00373, Pf16705" "889" "ENSG00000001631" "KRIT1" "A6NNU0; hsa:889; O00522; O43894; Q506L6; Q6U276; Q75N19; Q9H180; Q9H264; Q9HAX5" "" "" "0" "0" "0.999" "0.935" "1.051" "1.018" "0.970" "0.981" "0.990" "0.968" "0.993" "683.8" "682.9" "639.1" "718.6" "696.4" "663.5" "671.0" "676.9" "661.8" "679.0" "" "" "" "" "" "" "" "" "" "" "549.2" "492.8" "507.6" "481.4" "481.7" "497.8" "469.8" "494.3" "661.8" "552.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8491275537287957660" "False" "High" "IsMasterProtein" "Q8NDD1" "Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1orf131 PE=1 SV=4" "0.000" "False" "25.073" "14" "4" "6" "4" "293" "32.6" "9.88" "22.13" "4" "other biological processes" "nucleus;other cell component" "" "Pf15375" "128061" "ENSG00000143633" "C1orf131" "Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q8NDD1; Q96NM6" "" "" "0" "0" "1.123" "1.169" "1.193" "1.232" "1.095" "1.278" "1.257" "1.224" "1.214" "351.0" "394.0" "410.1" "418.6" "432.5" "384.2" "448.4" "441.2" "429.7" "426.0" "" "" "" "" "" "" "" "" "" "" "281.9" "284.3" "325.8" "280.5" "299.1" "288.3" "314.0" "322.2" "429.7" "346.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548420804533655280" "False" "High" "IsMasterProtein" "O43353" "Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2" "0.000" "False" "25.051" "10" "5" "5" "5" "540" "61.2" "7.09" "19.67" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00619, Pf07714" "8767" "ENSG00000104312" "RIPK2" "B7Z748; hsa:8767; O43353; Q6UWF0" "Downstream TCR signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1-dependent IKK and NF-kappa-B activation ; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor signaling pathway" "13" "0" "1.024" "1.046" "1.085" "1.033" "0.985" "1.022" "1.087" "1.006" "1.002" "822.7" "842.4" "860.2" "893.0" "849.9" "810.4" "841.0" "894.7" "827.7" "824.3" "" "" "" "" "" "" "" "" "" "" "660.8" "607.8" "683.3" "598.3" "587.8" "608.0" "588.8" "653.4" "827.7" "670.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3934808494784224808" "False" "High" "IsMasterProtein" "Q96FJ2" "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" "0.000" "False" "25.036" "57" "4" "10" "2" "89" "10.3" "7.37" "31.09" "4" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01221" "140735" "ENSG00000264364" "DYNLL2" "B2R5B4; hsa:140735; Q96FJ2" "MHC class II antigen presentation; HCMV Early Events; RHO GTPases Activate Formins; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BMF and translocation to mitochondria" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "19" "0" "1.061" "1.122" "1.109" "0.990" "1.105" "1.042" "1.065" "1.069" "1.101" "180.6" "191.6" "202.5" "200.2" "178.7" "199.5" "188.2" "192.3" "193.1" "198.9" "" "" "" "" "" "" "" "" "" "" "145.0" "138.2" "160.9" "134.1" "123.6" "149.7" "131.7" "140.4" "193.1" "161.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7489520263377738348" "False" "High" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "0.000" "False" "25.031" "17" "5" "6" "5" "357" "39.3" "8.10" "21.71" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.003" "1.080" "1.019" "1.057" "1.052" "1.072" "1.040" "1.002" "1.118" "545.7" "547.4" "589.1" "555.8" "576.6" "574.1" "585.2" "567.8" "546.7" "610.2" "" "" "" "" "" "" "" "" "" "" "438.3" "395.0" "468.0" "372.4" "398.8" "430.8" "409.8" "414.7" "546.7" "496.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3081383647301722280" "False" "High" "IsMasterProtein" "Q16540" "Large ribosomal subunit protein uL23m OS=Homo sapiens OX=9606 GN=MRPL23 PE=1 SV=1" "0.000" "False" "25.027" "27" "3" "4" "3" "153" "17.8" "9.69" "17.23" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00276" "6150" "ENSG00000214026; ENSG00000288141" "MRPL23" "A8MT29; hsa:6150; Q16540; Q96Q71" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.970" "1.008" "1.129" "1.171" "1.019" "1.072" "1.125" "1.067" "1.031" "208.7" "202.4" "210.4" "235.5" "244.3" "212.7" "223.8" "234.9" "222.7" "215.2" "" "" "" "" "" "" "" "" "" "" "167.6" "146.0" "167.2" "157.8" "169.0" "159.6" "156.7" "171.5" "222.7" "175.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2767038677570436707" "False" "High" "IsMasterProtein" "P82663" "Small ribosomal subunit protein mS25 OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1" "0.000" "False" "24.988" "36" "5" "5" "5" "173" "20.1" "8.82" "18.43" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "64432" "ENSG00000131368" "MRPS25" "B4DFJ5; B4DQG6; hsa:64432; P82663; Q9H7P5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.932" "0.975" "0.944" "0.899" "0.933" "0.924" "1.014" "0.917" "0.956" "264.6" "246.7" "258.0" "249.7" "237.8" "247.0" "244.5" "268.3" "242.7" "252.9" "" "" "" "" "" "" "" "" "" "" "212.5" "178.0" "204.9" "167.3" "164.5" "185.3" "171.2" "195.9" "242.7" "205.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097092162087690863" "False" "High" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "0.000" "False" "24.959" "7" "6" "9" "6" "1085" "122.3" "6.47" "26.47" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "9" "0" "1.123" "1.076" "1.070" "1.021" "1.007" "0.931" "0.935" "1.022" "1.035" "501.3" "563.1" "539.3" "536.3" "511.9" "504.9" "466.9" "468.9" "512.5" "518.7" "" "" "" "" "" "" "" "" "" "" "402.6" "406.3" "428.4" "359.3" "354.1" "378.8" "326.9" "342.5" "512.5" "421.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-827121188594037217" "False" "High" "IsMasterProtein" "Q6P1R4" "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS1L PE=1 SV=1" "0.000" "False" "24.946" "8" "2" "3" "2" "473" "53.2" "8.29" "13.64" "2" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01207" "64118" "ENSG00000169718" "DUS1L" "A6NHV4; hsa:64118; Q6P1R4; Q96AI3" "" "" "0" "0" "0.991" "0.984" "1.052" "1.083" "0.968" "0.990" "0.970" "1.151" "1.141" "210.5" "208.7" "207.2" "221.6" "228.0" "203.8" "208.4" "204.1" "242.2" "240.3" "" "" "" "" "" "" "" "" "" "" "169.1" "150.6" "164.6" "148.4" "157.7" "152.9" "145.9" "149.1" "242.2" "195.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6090359432096684388" "False" "High" "IsMasterProtein" "Q8NCN5" "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2" "0.000" "False" "24.946" "6" "5" "6" "5" "879" "99.3" "6.35" "22.05" "5" "" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "55066" "ENSG00000090857" "PDPR" "A7E298; A8K8Y7; B3KSE1; Q6AI20; Q6AWC9; Q8NCN5" "Regulation of pyruvate dehydrogenase (PDH) complex" "" "1" "0" "1.018" "0.950" "1.027" "1.160" "0.983" "1.028" "1.023" "1.022" "1.064" "276.8" "281.7" "262.9" "284.2" "321.0" "271.9" "284.5" "283.1" "282.9" "294.5" "" "" "" "" "" "" "" "" "" "" "222.3" "203.3" "208.8" "190.4" "222.0" "204.0" "199.2" "206.7" "282.9" "239.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053740260663860944" "False" "High" "IsMasterProtein" "Q9NZN8" "CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1" "0.000" "False" "24.940" "18" "7" "9" "7" "540" "59.7" "7.66" "27.30" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04153" "4848" "ENSG00000111596" "CNOT2" "hsa:4848; Q9H3E0; Q9NSX5; Q9NWR6; Q9NZN8; Q9P028" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "1.041" "1.003" "1.049" "1.050" "1.008" "1.062" "1.034" "1.009" "1.031" "857.1" "892.0" "859.7" "899.2" "900.1" "864.1" "910.5" "886.3" "864.4" "883.7" "" "" "" "" "" "" "" "" "" "" "688.4" "643.7" "682.9" "602.5" "622.5" "648.3" "637.5" "647.3" "864.4" "718.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3186791909088934819" "False" "High" "IsMasterProtein" "Q96JB2" "Conserved oligomeric Golgi complex subunit 3 OS=Homo sapiens OX=9606 GN=COG3 PE=1 SV=3" "0.000" "False" "24.937" "7" "6" "6" "6" "828" "94.0" "5.57" "22.29" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "" "Pf04136, Pf20671" "83548" "ENSG00000136152" "COG3" "B2RAW5; hsa:83548; Q5VT70; Q8IXX4; Q96JB2; Q9BZ92" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "1.014" "0.943" "1.059" "1.052" "1.021" "0.984" "1.007" "1.021" "1.128" "352.4" "357.2" "332.3" "373.3" "370.7" "359.7" "346.7" "354.9" "359.7" "397.5" "" "" "" "" "" "" "" "" "" "" "283.0" "257.8" "264.0" "250.1" "256.4" "269.9" "242.7" "259.2" "359.7" "323.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406429710445880592" "False" "High" "IsMasterProtein" "Q14511" "Enhancer of filamentation 1 OS=Homo sapiens OX=9606 GN=NEDD9 PE=1 SV=1" "0.000" "False" "24.933" "9" "6" "7" "6" "834" "92.8" "6.70" "20.01" "6" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08824, Pf12026, Pf14604" "4739" "ENSG00000111859" "NEDD9" "A8K9G7; A8MSJ9; G5E9Y9; hsa:4739; Q14511; Q5T9R4; Q5XKI0" "" "TGF-beta signaling pathway; HDAC6 interactions in the central nervous system" "2" "0" "1.023" "0.997" "1.063" "0.974" "1.021" "1.035" "1.019" "1.020" "1.052" "502.1" "513.8" "500.8" "534.0" "489.0" "512.6" "519.5" "511.7" "512.0" "528.2" "" "" "" "" "" "" "" "" "" "" "403.3" "370.7" "397.8" "357.8" "338.2" "384.6" "363.7" "373.7" "512.0" "429.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7283076570857654598" "False" "High" "IsMasterProtein" "Q96F44" "E3 ubiquitin-protein ligase TRIM11 OS=Homo sapiens OX=9606 GN=TRIM11 PE=1 SV=2" "0.000" "False" "24.911" "9" "3" "5" "3" "468" "52.7" "5.69" "18.72" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "81559" "ENSG00000154370" "TRIM11" "A6NKE2; B2RB82; B3KUS3; B4DX88; hsa:81559; Q5VSU1; Q8NCA6; Q96F44; Q9C022" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.150" "1.022" "1.178" "1.019" "0.933" "1.219" "1.203" "1.131" "1.035" "179.9" "206.8" "183.8" "211.9" "183.3" "167.8" "219.2" "216.5" "203.5" "186.2" "" "" "" "" "" "" "" "" "" "" "144.5" "149.2" "146.0" "141.9" "126.8" "125.9" "153.5" "158.1" "203.5" "151.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7748730165992048021" "False" "High" "IsMasterProtein" "Q6UWE0" "E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens OX=9606 GN=LRSAM1 PE=1 SV=1" "0.000" "False" "24.895" "10" "7" "8" "7" "723" "83.5" "5.94" "25.16" "7" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf07647, Pf13855, Pf13920" "90678" "ENSG00000148356" "LRSAM1" "Q5VVV0; Q6UWE0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7" "Antigen processing: Ubiquitination & Proteasome degradation" "Intracellular trafficking proteins involved in CMT neuropathy" "2" "0" "1.033" "0.960" "1.179" "1.070" "0.998" "1.122" "0.993" "1.062" "1.039" "613.1" "633.1" "588.9" "723.1" "655.9" "611.8" "688.2" "608.8" "651.2" "637.1" "" "" "" "" "" "" "" "" "" "" "492.4" "456.9" "467.7" "484.5" "453.6" "459.0" "481.8" "444.6" "651.2" "518.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218003044822153883" "False" "High" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "0.000" "False" "24.867" "38" "6" "6" "6" "172" "19.2" "5.40" "21.14" "6" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "0.941" "0.930" "0.992" "0.961" "1.056" "1.005" "0.928" "0.889" "0.993" "745.2" "701.5" "692.8" "739.2" "716.2" "787.3" "748.7" "691.2" "662.2" "740.4" "" "" "" "" "" "" "" "" "" "" "598.5" "506.2" "550.3" "495.3" "495.3" "590.7" "524.2" "504.8" "662.2" "602.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7953357218888963531" "False" "High" "IsMasterProtein" "Q3KQU3" "MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1" "0.000" "False" "24.858" "8" "7" "13" "7" "841" "92.8" "10.11" "32.77" "7" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf05672" "55700" "ENSG00000116871" "MAP7D1" "D3DPS4; hsa:55700; Q3KQU3; Q7L8J5; Q8N905; Q8TAK0; Q9HBQ2; Q9NW29; Q9ULN3" "" "" "0" "0" "0.709" "0.574" "1.003" "0.393" "0.768" "1.185" "0.593" "0.825" "1.107" "19.8" "14.0" "11.4" "19.9" "7.8" "15.2" "23.5" "11.7" "16.3" "21.9" "" "" "" "" "" "" "" "" "" "" "15.9" "10.1" "9.0" "13.3" "5.4" "11.4" "16.4" "8.6" "16.3" "17.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4943929285707188175" "False" "High" "IsMasterProtein" "O60294" "tRNA wybutosine-synthesizing protein 4 OS=Homo sapiens OX=9606 GN=LCMT2 PE=1 SV=3" "0.000" "False" "24.853" "5" "2" "3" "2" "686" "75.6" "6.73" "15.27" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf04072" "9836" "ENSG00000168806" "LCMT2" "hsa:9836; O60294; Q4JFT6; Q96B55; Q9NR10" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "1.200" "1.514" "1.453" "1.209" "1.016" "1.305" "1.227" "1.084" "1.402" "40.6" "48.7" "61.5" "59.0" "49.1" "41.3" "53.0" "49.8" "44.0" "56.9" "" "" "" "" "" "" "" "" "" "" "32.6" "35.2" "48.8" "39.5" "34.0" "31.0" "37.1" "36.4" "44.0" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482584710342815386" "False" "High" "IsMasterProtein" "Q15773" "Myeloid leukemia factor 2 OS=Homo sapiens OX=9606 GN=MLF2 PE=1 SV=1" "0.000" "False" "24.850" "22" "4" "9" "4" "248" "28.1" "6.90" "25.64" "4" "other biological processes" "nucleus;other cell component" "" "Pf10248" "8079" "ENSG00000089693" "MLF2" "hsa:8079; Q15773" "" "" "0" "0" "0.951" "0.954" "0.977" "0.929" "0.974" "1.054" "1.019" "0.985" "0.982" "400.0" "380.5" "381.8" "391.0" "371.6" "389.6" "421.7" "407.8" "394.1" "392.7" "" "" "" "" "" "" "" "" "" "" "321.3" "274.6" "303.3" "262.0" "257.0" "292.3" "295.3" "297.8" "394.1" "319.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "524672605360435536" "False" "High" "IsMasterProtein" "O95273" "Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2" "0.000" "False" "24.814" "13" "5" "7" "5" "360" "40.2" "4.82" "23.35" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf13324, Pf20936" "23582" "ENSG00000166946" "CCNDBP1" "A8K3Q0; A8K3U2; hsa:23582; O95273; Q6ZQN9; Q7Z519; Q8NBS7; Q8NBY2; Q9NS19; Q9NYH3; Q9UHX9" "" "" "0" "0" "0.980" "0.924" "1.020" "0.972" "0.970" "0.916" "1.047" "1.030" "0.964" "553.8" "542.8" "511.8" "564.8" "538.5" "537.0" "507.2" "579.7" "570.6" "534.0" "" "" "" "" "" "" "" "" "" "" "444.8" "391.7" "406.5" "378.4" "372.4" "402.9" "355.1" "423.3" "570.6" "434.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-10968856719763814" "False" "High" "IsMasterProtein" "P62081" "Small ribosomal subunit protein eS7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "0.000" "False" "24.732" "23" "5" "9" "5" "194" "22.1" "10.10" "24.68" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "0.908" "1.141" "1.111" "1.122" "1.120" "1.157" "1.094" "1.081" "1.029" "706.0" "641.0" "805.5" "784.1" "792.4" "791.0" "817.0" "772.7" "763.1" "726.5" "" "" "" "" "" "" "" "" "" "" "567.1" "462.5" "639.8" "525.3" "548.0" "593.4" "572.0" "564.3" "763.1" "590.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538094465215650253" "False" "High" "IsMasterProtein" "Q8N4J0" "Carnosine N-methyltransferase OS=Homo sapiens OX=9606 GN=CARNMT1 PE=1 SV=1" "0.000" "False" "24.687" "14" "5" "5" "5" "409" "47.2" "6.32" "20.07" "5" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07942" "138199" "ENSG00000156017" "CARNMT1" "hsa:138199; Q7Z383; Q8N4J0; Q8N7C5" "Histidine catabolism" "" "1" "0" "0.993" "0.975" "1.018" "0.999" "0.938" "0.995" "0.925" "0.967" "1.062" "546.7" "543.0" "533.2" "556.5" "545.9" "513.0" "544.1" "505.7" "528.5" "580.8" "" "" "" "" "" "" "" "" "" "" "439.1" "391.8" "423.5" "372.9" "377.5" "384.9" "380.9" "369.3" "528.5" "472.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594360635056461095" "False" "High" "IsMasterProtein" "O75648" "Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens OX=9606 GN=TRMU PE=1 SV=2" "0.000" "False" "24.685" "10" "4" "5" "4" "421" "47.7" "8.03" "19.80" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf03054, Pf20258, Pf20259" "55687" "ENSG00000100416" "TRMU" "A8K3U7; hsa:55687; O75648; Q05C99; Q5W9C8; Q66K31; Q6ICC3; Q9NWC1" "tRNA modification in the mitochondrion" "" "1" "0" "1.152" "1.153" "1.121" "1.032" "1.085" "1.073" "1.095" "1.036" "1.091" "274.4" "316.1" "316.5" "307.6" "283.2" "297.6" "294.5" "300.5" "284.3" "299.2" "" "" "" "" "" "" "" "" "" "" "220.4" "228.1" "251.4" "206.1" "195.9" "223.3" "206.2" "219.5" "284.3" "243.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634668291009869452" "False" "High" "IsMasterProtein" "Q9UNP9" "Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1" "0.000" "False" "24.651" "19" "6" "7" "5" "301" "33.4" "5.60" "19.06" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00160" "10450" "ENSG00000084072" "PPIE" "B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9" "mRNA Splicing - Major Pathway; Neutrophil degranulation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "6" "0" "0.992" "1.044" "1.073" "0.978" "1.096" "1.101" "1.011" "0.991" "1.015" "841.4" "834.2" "878.2" "902.5" "823.2" "922.2" "926.1" "850.3" "834.1" "854.3" "" "" "" "" "" "" "" "" "" "" "675.8" "602.0" "697.6" "604.7" "569.3" "691.9" "648.4" "621.0" "834.1" "694.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5023759696218809409" "False" "High" "IsMasterProtein" "Q7Z434" "Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2" "0.000" "False" "24.633" "10" "3" "4" "3" "540" "56.5" "5.52" "19.84" "3" "stress response;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16739" "57506" "ENSG00000088888" "MAVS" "A8K6X0; B2BD33; B2BD34; F5H6C8; hsa:57506; M1P2Z0; Q2HWT5; Q3I0Y2; Q5T7I6; Q7Z434; Q86VY7; Q9H1H3; Q9H4Y1; Q9H8D3; Q9ULE9" "TRAF6 mediated NF-kB activation; SARS-CoV-1 activates/modulates innate immune responses; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "24" "0" "1.030" "1.005" "1.140" "1.107" "0.981" "1.043" "1.064" "1.107" "1.065" "278.5" "286.7" "279.9" "317.4" "308.3" "273.3" "290.4" "296.2" "308.2" "296.6" "" "" "" "" "" "" "" "" "" "" "223.7" "206.9" "222.3" "212.7" "213.2" "205.0" "203.3" "216.3" "308.2" "241.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844902181037291409" "False" "High" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "0.000" "False" "24.621" "20" "3" "8" "3" "119" "13.3" "11.56" "32.64" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "mRNA processing" "5" "0" "1.015" "1.032" "1.032" "0.985" "0.990" "0.964" "1.025" "0.974" "0.979" "447.9" "454.6" "462.2" "462.4" "441.1" "443.2" "431.6" "458.9" "436.2" "438.4" "" "" "" "" "" "" "" "" "" "" "359.7" "328.0" "367.1" "309.8" "305.1" "332.6" "302.2" "335.1" "436.2" "356.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4146618986531713622" "False" "High" "IsMasterProtein" "P46782" "Small ribosomal subunit protein uS7 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "0.000" "False" "24.601" "29" "6" "16" "6" "204" "22.9" "9.72" "28.94" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.988" "1.109" "1.059" "1.055" "1.108" "1.114" "1.063" "1.149" "1.051" "763.9" "754.5" "847.3" "809.1" "806.2" "846.7" "851.1" "812.1" "877.4" "802.6" "" "" "" "" "" "" "" "" "" "" "613.5" "544.4" "673.1" "542.1" "557.6" "635.3" "595.9" "593.1" "877.4" "652.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5049084120360688973" "False" "High" "IsMasterProtein" "Q6PL24" "Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1" "0.000" "False" "24.584" "12" "4" "11" "4" "325" "35.7" "4.74" "34.10" "4" "" "" "" "Pf13897" "283578" "ENSG00000100580" "TMED8" "B3KTI6; hsa:283578; Q3MJB0; Q6PL24; Q9P1V9" "" "" "0" "0" "1.018" "0.997" "0.986" "0.950" "1.031" "0.942" "0.937" "0.979" "0.960" "652.2" "664.0" "650.3" "643.3" "619.5" "672.5" "614.1" "611.1" "638.2" "626.3" "" "" "" "" "" "" "" "" "" "" "523.8" "479.1" "516.5" "431.0" "428.4" "504.6" "430.0" "446.3" "638.2" "509.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6108723454848240584" "False" "High" "IsMasterProtein" "Q7L7X3" "Serine/threonine-protein kinase TAO1 OS=Homo sapiens OX=9606 GN=TAOK1 PE=1 SV=1" "0.000" "False" "24.584" "6" "6" "8" "4" "1001" "116.0" "7.65" "23.07" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "57551" "ENSG00000160551" "TAOK1" "A2RUT8; B7ZLV6; hsa:57551; Q7L7X3; Q96L75; Q9H2K7; Q9H7S5; Q9P2I6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation; MAPK signaling pathway" "8" "0" "1.167" "0.940" "1.179" "0.968" "1.097" "1.112" "0.776" "0.994" "0.849" "36.2" "42.3" "34.1" "42.7" "35.1" "39.7" "40.3" "28.1" "36.0" "30.8" "" "" "" "" "" "" "" "" "" "" "29.1" "30.5" "27.1" "28.6" "24.3" "29.8" "28.2" "20.5" "36.0" "25.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316205606070741097" "False" "High" "IsMasterProtein" "Q5JTD0" "Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1" "0.000" "False" "24.565" "12" "6" "7" "6" "557" "61.8" "5.97" "19.35" "6" "cell organization and biogenesis" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf15453" "93643" "ENSG00000137221" "TJAP1" "hsa:93643; Q05BH9; Q5JTD0; Q5JTD1; Q5JWW1; Q68DB2; Q6P2P3; Q9H7V7" "" "" "0" "0" "1.107" "1.148" "1.141" "1.028" "1.049" "1.137" "1.013" "1.091" "1.026" "111.7" "123.6" "128.2" "127.4" "114.8" "117.1" "127.0" "113.1" "121.8" "114.6" "" "" "" "" "" "" "" "" "" "" "89.7" "89.2" "101.8" "85.4" "79.4" "87.9" "88.9" "82.6" "121.8" "93.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "431909028806853544" "False" "High" "IsMasterProtein" "Q9H082" "Ras-related protein Rab-33B OS=Homo sapiens OX=9606 GN=RAB33B PE=1 SV=1" "0.000" "False" "24.524" "17" "4" "8" "1" "229" "25.7" "7.18" "30.55" "4" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "83452" "ENSG00000172007" "RAB33B" "B2R987; hsa:83452; Q4W5B0; Q9H082" "TBC/RABGAPs; RAB geranylgeranylation; Intra-Golgi traffic" "" "3" "2" "1.041" "1.055" "1.011" "1.000" "1.058" "1.053" "0.970" "1.014" "1.069" "553.7" "576.5" "583.9" "560.1" "553.8" "585.8" "582.8" "537.2" "561.5" "592.2" "" "" "" "" "" "" "" "" "" "" "444.7" "416.0" "463.8" "375.2" "383.0" "439.5" "408.1" "392.3" "561.5" "481.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4889317708786741676" "False" "High" "IsMasterProtein" "Q96AT1" "Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2" "0.000" "False" "24.508" "43" "6" "7" "6" "154" "17.5" "6.11" "26.15" "6" "" "" "" "Pf15377" "57456" "ENSG00000163807; ENSG00000281665" "KIAA1143" "A8K0I4; hsa:57456; Q96AT1; Q96HJ8; Q9ULS7" "" "" "0" "0" "1.049" "0.959" "1.054" "1.020" "1.085" "0.941" "1.008" "0.927" "0.975" "403.6" "423.5" "387.1" "425.5" "411.6" "437.8" "379.9" "407.0" "374.1" "393.4" "" "" "" "" "" "" "" "" "" "" "324.2" "305.6" "307.5" "285.1" "284.7" "328.5" "266.0" "297.2" "374.1" "320.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273003467290879098" "False" "High" "IsMasterProtein" "Q9UNE7" "E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2" "0.000" "False" "24.507" "20" "6" "7" "6" "303" "34.8" "5.87" "20.35" "6" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf04564, Pf12895, Pf18391" "10273" "ENSG00000103266" "STUB1" "A2IDB9; O60526; Q969U2; Q9HBT1; Q9UNE7" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Regulation of TNFR1 signaling; Downregulation of TGF-beta receptor signaling" "Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "11" "0" "1.017" "0.953" "0.985" "1.013" "1.076" "1.044" "0.946" "1.049" "1.056" "361.8" "368.0" "344.8" "356.5" "366.6" "389.2" "377.6" "342.1" "379.7" "382.1" "" "" "" "" "" "" "" "" "" "" "290.6" "265.5" "273.9" "238.8" "253.5" "292.0" "264.4" "249.9" "379.7" "310.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3080210265663367666" "False" "High" "IsMasterProtein" "Q8IY37" "Probable ATP-dependent RNA helicase DHX37 OS=Homo sapiens OX=9606 GN=DHX37 PE=1 SV=1" "0.000" "False" "24.493" "5" "4" "4" "4" "1157" "129.5" "8.10" "15.85" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "57647" "ENSG00000150990" "DHX37" "hsa:57647; Q8IY37; Q9BUI7; Q9P211" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.998" "1.138" "1.189" "1.229" "1.212" "1.235" "1.118" "1.263" "1.251" "164.4" "164.1" "187.2" "195.5" "202.1" "199.3" "203.2" "183.8" "207.7" "205.7" "" "" "" "" "" "" "" "" "" "" "132.1" "118.4" "148.7" "131.0" "139.7" "149.5" "142.2" "134.2" "207.7" "167.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837878793854205649" "False" "High" "IsMasterProtein" "Q9BVL2" "Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1" "0.000" "False" "24.442" "13" "6" "7" "6" "599" "60.9" "9.33" "21.47" "6" "transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf15967" "9818" "ENSG00000139496" "NUP58" "A6NI12; B4DZJ1; hsa:9818; O43160; Q5JRG2; Q5JRG5; Q9BVL2" "" "" "0" "0" "1.020" "0.985" "1.093" "1.146" "0.989" "1.106" "1.093" "1.066" "0.962" "233.8" "238.4" "230.2" "255.5" "268.0" "231.3" "258.7" "255.6" "249.3" "225.0" "" "" "" "" "" "" "" "" "" "" "187.8" "172.1" "182.9" "171.2" "185.3" "173.5" "181.1" "186.7" "249.3" "182.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049018417817342026" "False" "High" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "0.000" "False" "24.383" "20" "7" "7" "7" "229" "25.2" "4.64" "24.57" "7" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation" "11" "0" "0.938" "0.952" "1.099" "1.055" "1.117" "1.115" "1.001" "1.048" "0.973" "595.3" "558.2" "566.9" "654.5" "628.0" "664.8" "663.5" "595.9" "623.8" "579.4" "" "" "" "" "" "" "" "" "" "" "478.2" "402.8" "450.3" "438.5" "434.3" "498.8" "464.6" "435.2" "623.8" "471.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8259676648144024034" "False" "High" "IsMasterProtein" "Q6NT76" "Homeobox-containing protein 1 OS=Homo sapiens OX=9606 GN=HMBOX1 PE=1 SV=1" "0.000" "False" "24.372" "10" "3" "5" "3" "420" "47.2" "6.06" "20.52" "3" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf04814" "79618" "ENSG00000147421" "HMBOX1" "A4K385; A8K3R8; B4DHY5; D3DSU0; hsa:79618; Q3Y6P1; Q6NT76; Q96GS5; Q9H701" "" "miR-222 in exercise-induced cardiac growth" "1" "0" "0.994" "0.934" "1.002" "1.050" "1.040" "1.077" "1.078" "1.052" "1.099" "180.0" "179.0" "168.1" "180.4" "189.0" "187.2" "193.8" "194.1" "189.3" "197.9" "" "" "" "" "" "" "" "" "" "" "144.6" "129.1" "133.5" "120.8" "130.7" "140.5" "135.7" "141.7" "189.3" "160.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3529380218292263569" "False" "High" "IsMasterProtein" "P05423" "DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2" "0.000" "False" "24.370" "13" "5" "6" "5" "398" "44.4" "6.98" "19.60" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05132" "661" "ENSG00000168495" "POLR3D" "hsa:661; P05423; Q6FI28; Q9BPV7; Q9BPZ1; Q9BXB3" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "1.022" "0.967" "0.973" "0.938" "0.912" "0.896" "0.972" "0.937" "0.919" "542.2" "553.9" "524.5" "527.6" "508.6" "494.6" "486.0" "527.2" "507.9" "498.4" "" "" "" "" "" "" "" "" "" "" "435.5" "399.7" "416.6" "353.5" "351.7" "371.1" "340.3" "385.0" "507.9" "405.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933649257231024003" "False" "High" "IsMasterProtein" "P16930" "Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2" "0.000" "False" "24.341" "11" "4" "5" "4" "419" "46.3" "6.95" "19.01" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01557, Pf09298" "2184" "ENSG00000103876" "FAH" "B2R9X1; D3DW95; hsa:2184; P16930; Q53XA7" "Tyrosine catabolism" "Amino acid metabolism" "2" "0" "1.029" "1.194" "1.129" "0.926" "1.042" "0.895" "0.767" "0.917" "0.922" "252.2" "259.4" "301.2" "284.7" "233.5" "262.8" "225.6" "193.4" "231.2" "232.5" "" "" "" "" "" "" "" "" "" "" "202.5" "187.1" "239.3" "190.7" "161.5" "197.1" "157.9" "141.2" "231.2" "189.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3626479859969264661" "False" "High" "IsMasterProtein" "Q96QG7" "Myotubularin-related protein 9 OS=Homo sapiens OX=9606 GN=MTMR9 PE=1 SV=1" "0.000" "False" "24.331" "12" "6" "7" "6" "549" "63.4" "6.39" "20.37" "6" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf06602, Pf21098" "66036" "ENSG00000104643; ENSG00000285032" "MTMR9" "B7Z291; hsa:66036; Q52LU3; Q8WW11; Q96QG6; Q96QG7; Q9NX50" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "8p23.1 copy number variation syndrome" "4" "0" "1.067" "1.016" "1.091" "1.025" "0.940" "1.046" "1.046" "1.019" "1.039" "278.6" "297.2" "283.1" "303.9" "285.6" "261.9" "291.4" "291.4" "284.0" "289.6" "" "" "" "" "" "" "" "" "" "" "223.8" "214.4" "224.9" "203.6" "197.5" "196.5" "204.0" "212.8" "284.0" "235.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "244400377751924858" "False" "High" "IsMasterProtein" "Q9HCE0" "Ectopic P granules protein 5 homolog OS=Homo sapiens OX=9606 GN=EPG5 PE=1 SV=2" "0.000" "False" "24.284" "2" "5" "6" "5" "2579" "292.3" "6.43" "22.33" "5" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other cytoplasmic organelle;other cell component" "" "" "57724" "ENSG00000152223" "EPG5" "A2BDF3; hsa:57724; Q9H8C8; Q9HCE0" "" "" "0" "0" "1.072" "1.045" "1.063" "1.021" "0.981" "0.888" "1.038" "1.016" "1.113" "334.5" "358.6" "349.6" "355.6" "341.4" "328.3" "297.1" "347.1" "339.9" "372.3" "" "" "" "" "" "" "" "" "" "" "268.7" "258.7" "277.7" "238.3" "236.1" "246.3" "208.0" "253.5" "339.9" "302.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7182522188647620429" "False" "High" "IsMasterProtein" "Q8N3L3" "Beta-taxilin OS=Homo sapiens OX=9606 GN=TXLNB PE=1 SV=3" "0.000" "False" "24.275" "11" "6" "7" "6" "684" "76.5" "4.93" "22.58" "6" "" "other cell component" "other molecular function" "Pf09728" "167838" "ENSG00000164440" "TXLNB" "hsa:167838; Q5HYH7; Q5VTF3; Q76L25; Q86T52; Q8N3L3; Q8N3S2" "" "" "0" "0" "1.261" "0.967" "1.162" "1.075" "1.090" "0.975" "0.959" "1.024" "1.135" "156.4" "197.2" "151.2" "181.7" "168.1" "170.4" "152.5" "149.9" "160.2" "177.5" "" "" "" "" "" "" "" "" "" "" "125.6" "142.3" "120.1" "121.7" "116.3" "127.9" "106.8" "109.5" "160.2" "144.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9132635867397603913" "False" "High" "IsMasterProtein" "Q53T59" "HCLS1-binding protein 3 OS=Homo sapiens OX=9606 GN=HS1BP3 PE=1 SV=1" "0.000" "False" "24.261" "9" "3" "4" "3" "392" "42.8" "5.01" "18.31" "3" "other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00787" "64342" "ENSG00000118960" "HS1BP3" "B2RAW2; D6W529; hsa:64342; Q53T59; Q86VC2; Q8N367" "" "" "0" "0" "1.061" "1.005" "1.089" "1.187" "0.984" "1.060" "1.031" "1.040" "1.103" "200.4" "212.7" "201.4" "218.2" "238.0" "197.1" "212.5" "206.6" "208.5" "221.0" "" "" "" "" "" "" "" "" "" "" "161.0" "153.4" "160.0" "146.2" "164.6" "147.9" "148.8" "150.9" "208.5" "179.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2880199082589634412" "False" "High" "IsMasterProtein" "P30281" "G1/S-specific cyclin-D3 OS=Homo sapiens OX=9606 GN=CCND3 PE=1 SV=2" "0.000" "False" "24.255" "13" "4" "5" "4" "292" "32.5" "7.06" "18.52" "4" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf02984" "896" "ENSG00000112576" "CCND3" "B2RD63; B3KQ22; E9PAS4; E9PB36; hsa:896; P30281; Q5T8J0; Q6FG62; Q96F49" "Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Retinoblastoma gene in cancer; Focal adhesion; Overview of nanoparticle effects; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Measles virus infection; Pleural mesothelioma; JAK-STAT signaling in the regulation of beta cells; DNA damage response; DNA damage response (only ATM dependent)" "24" "0" "1.025" "0.956" "0.995" "1.061" "0.957" "1.248" "1.284" "1.294" "1.118" "512.0" "524.9" "489.5" "509.3" "543.3" "490.1" "639.2" "657.4" "662.5" "572.4" "" "" "" "" "" "" "" "" "" "" "411.3" "378.8" "388.8" "341.2" "375.7" "367.7" "447.5" "480.1" "662.5" "465.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194436757358923865" "False" "High" "IsMasterProtein" "Q5W0V3" "FHF complex subunit HOOK interacting protein 2A OS=Homo sapiens OX=9606 GN=FHIP2A PE=1 SV=1" "0.000" "False" "24.241" "8" "5" "5" "5" "765" "86.5" "5.29" "14.53" "5" "" "" "" "Pf10257, Pf19311, Pf19314" "57700" "ENSG00000151553" "FHIP2A" "Q5H9P7; Q5W0V2; Q5W0V3; Q8IY76; Q9HCH2" "" "" "0" "0" "1.034" "1.047" "1.097" "1.057" "1.042" "1.038" "1.032" "1.091" "1.034" "465.7" "481.7" "487.7" "511.1" "492.0" "485.3" "483.5" "480.4" "508.1" "481.6" "" "" "" "" "" "" "" "" "" "" "374.0" "347.6" "387.4" "342.4" "340.3" "364.1" "338.6" "350.8" "508.1" "391.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2837359330570591993" "False" "High" "IsMasterProtein" "Q15022" "Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3" "0.000" "False" "24.228" "6" "4" "4" "4" "739" "83.0" "8.81" "19.10" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf09733" "23512" "ENSG00000178691" "SUZ12" "hsa:23512; Q15022; Q96BD9" "HCMV Early Events; SUMOylation of chromatin organization proteins; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines" "Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; NF1 copy number variation syndrome" "15" "0" "1.039" "1.066" "1.014" "0.959" "0.958" "1.117" "1.066" "1.126" "1.011" "568.4" "590.7" "605.8" "576.2" "544.9" "544.7" "634.9" "605.6" "640.0" "574.4" "" "" "" "" "" "" "" "" "" "" "456.5" "426.2" "481.2" "386.1" "376.9" "408.7" "444.6" "442.3" "640.0" "467.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "408480103546989940" "False" "High" "IsMasterProtein" "Q9Y4C1" "Lysine-specific demethylase 3A OS=Homo sapiens OX=9606 GN=KDM3A PE=1 SV=4" "0.000" "False" "24.182" "6" "8" "10" "6" "1321" "147.2" "8.07" "23.69" "8" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "55818" "ENSG00000115548" "KDM3A" "D6W5M3; hsa:55818; Q53S72; Q68D47; Q68UT9; Q6N050; Q8IY08; Q9Y4C1" "HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression" "5" "0" "0.962" "0.839" "1.117" "1.060" "0.824" "0.875" "1.007" "0.906" "1.005" "117.3" "112.8" "98.4" "130.9" "124.3" "96.7" "102.6" "118.0" "106.2" "117.8" "" "" "" "" "" "" "" "" "" "" "94.2" "81.4" "78.2" "87.7" "85.9" "72.5" "71.9" "86.2" "106.2" "95.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3508649530452010436" "False" "High" "IsMasterProtein" "P00167" "Cytochrome b5 OS=Homo sapiens OX=9606 GN=CYB5A PE=1 SV=2" "0.000" "False" "24.149" "32" "3" "3" "3" "134" "15.3" "4.96" "16.28" "3" "transport" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00173" "1528" "ENSG00000166347" "CYB5A" "A8MV91; F8WEU4; hsa:1528; P00167; Q6IB14" "Vitamin C (ascorbate) metabolism" "Oxidation by cytochrome P450" "2" "0" "1.023" "1.028" "1.017" "1.130" "1.076" "1.094" "1.162" "1.149" "1.095" "482.8" "493.7" "496.2" "490.9" "545.6" "519.4" "528.3" "560.9" "554.5" "528.6" "" "" "" "" "" "" "" "" "" "" "387.8" "356.3" "394.1" "328.9" "377.4" "389.7" "369.9" "409.6" "554.5" "429.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407060077554528043" "False" "High" "IsMasterProtein" "Q5T3I0" "G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2" "0.000" "False" "24.116" "17" "7" "9" "7" "446" "50.4" "9.63" "26.24" "7" "" "nucleus" "" "Pf01585" "" "ENSG00000292251" "GPATCH4" "Q5T3I0; Q5T3I1; Q6ZUE7; Q8IWG8; Q9NXH4" "" "" "0" "0" "1.063" "1.168" "1.231" "1.212" "1.119" "1.292" "1.339" "1.253" "1.227" "125.8" "133.8" "146.9" "154.9" "152.5" "140.8" "162.6" "168.5" "157.6" "154.4" "" "" "" "" "" "" "" "" "" "" "101.1" "96.5" "116.7" "103.8" "105.5" "105.6" "113.8" "123.0" "157.6" "125.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "120688063892906197" "False" "High" "IsMasterProtein" "Q6P4R8" "Nuclear factor related to kappa-B-binding protein OS=Homo sapiens OX=9606 GN=NFRKB PE=1 SV=2" "0.000" "False" "24.097" "6" "6" "6" "6" "1299" "138.9" "9.25" "15.16" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf14465" "4798" "ENSG00000170322" "NFRKB" "hsa:4798; Q12869; Q15312; Q6P4R8; Q9H048" "DNA Damage Recognition in GG-NER; UCH proteinases" "Overview of nanoparticle effects" "3" "0" "1.048" "0.947" "0.929" "0.999" "1.056" "0.915" "1.035" "1.085" "1.027" "153.7" "161.1" "145.5" "142.7" "153.6" "162.3" "140.7" "159.1" "166.8" "157.8" "" "" "" "" "" "" "" "" "" "" "123.4" "116.3" "115.6" "95.6" "106.2" "121.7" "98.5" "116.2" "166.8" "128.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036187621347807091" "False" "High" "IsMasterProtein" "P23469" "Receptor-type tyrosine-protein phosphatase epsilon OS=Homo sapiens OX=9606 GN=PTPRE PE=1 SV=1" "0.000" "False" "24.081" "7" "4" "5" "4" "700" "80.6" "7.02" "16.99" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00102" "5791" "ENSG00000132334" "PTPRE" "hsa:5791; P23469; Q13345; Q5VWH3; Q5VWH4; Q96KQ6" "" "" "0" "0" "1.091" "1.010" "1.071" "1.003" "0.996" "0.998" "1.024" "0.909" "1.010" "227.6" "248.3" "229.8" "243.6" "228.2" "226.6" "227.2" "233.0" "206.7" "229.9" "" "" "" "" "" "" "" "" "" "" "182.8" "179.2" "182.6" "163.2" "157.8" "170.0" "159.1" "170.1" "206.7" "187.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764282473727919069" "False" "High" "IsMasterProtein" "Q96K17" "Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1" "0.000" "False" "24.059" "27" "5" "7" "3" "158" "17.3" "6.35" "24.97" "5" "" "" "" "Pf01849" "91408" "ENSG00000134717" "BTF3L4" "B3KNJ1; D3DQ32; G3V1C6; hsa:91408; Q96K17" "" "" "0" "0" "0.981" "0.945" "0.916" "0.884" "0.979" "0.883" "0.888" "0.829" "0.944" "282.4" "277.1" "266.8" "258.6" "249.7" "276.4" "249.3" "250.8" "234.2" "266.6" "" "" "" "" "" "" "" "" "" "" "226.8" "200.0" "211.9" "173.2" "172.7" "207.4" "174.5" "183.1" "234.2" "216.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-989694424414112882" "False" "High" "IsMasterProtein" "Q6P2P2" "Protein arginine N-methyltransferase 9 OS=Homo sapiens OX=9606 GN=PRMT9 PE=1 SV=1" "0.000" "False" "24.049" "8" "6" "6" "6" "845" "94.4" "5.25" "21.72" "6" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf06325" "90826" "ENSG00000164169" "PRMT9" "A8KA39; B3KU92; hsa:90826; Q6P2P2; Q6ZR58; Q8N383; Q9BT55; Q9NT98" "" "" "0" "0" "0.974" "1.053" "1.028" "1.024" "0.983" "0.927" "0.980" "0.997" "1.073" "410.0" "399.5" "431.8" "421.5" "420.1" "403.2" "380.3" "402.0" "408.6" "440.1" "" "" "" "" "" "" "" "" "" "" "329.3" "288.3" "343.0" "282.4" "290.5" "302.5" "266.3" "293.5" "408.6" "357.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531201272546720497" "False" "High" "IsMasterProtein" "P14854" "Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2" "0.000" "False" "24.046" "52" "4" "7" "4" "86" "10.2" "7.05" "24.94" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02297" "1340" "ENSG00000126267" "COX6B1" "B2R5C9; hsa:1340; P14854; Q6IBL4" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "7" "0" "1.013" "0.977" "0.984" "1.054" "1.050" "1.038" "1.111" "1.006" "1.035" "310.0" "314.0" "302.7" "304.9" "326.8" "325.5" "321.6" "344.5" "311.8" "320.8" "" "" "" "" "" "" "" "" "" "" "249.0" "226.6" "240.5" "204.3" "226.0" "244.2" "225.2" "251.6" "311.8" "260.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1246779234316334068" "False" "High" "IsMasterProtein" "P49773" "Adenosine 5'-monophosphoramidase HINT1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "0.000" "False" "24.038" "51" "4" "8" "4" "126" "13.8" "6.95" "36.84" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "0.994" "0.973" "0.938" "1.021" "0.986" "1.084" "1.062" "0.930" "0.960" "648.9" "644.8" "631.2" "608.4" "662.4" "639.6" "703.7" "689.3" "603.3" "623.0" "" "" "" "" "" "" "" "" "" "" "521.2" "465.2" "501.4" "407.6" "458.1" "479.9" "492.7" "503.4" "603.3" "506.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3162421235115001887" "False" "High" "IsMasterProtein" "L0R819" "ASNSD1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=ASDURF PE=1 SV=1" "0.000" "False" "24.027" "42" "4" "6" "4" "96" "11.2" "8.88" "19.10" "4" "other biological processes" "other cell component" "" "" "" "ENSG00000286053" "ASDURF" "L0R819" "" "" "0" "0" "1.036" "1.002" "1.043" "1.047" "1.087" "1.048" "1.141" "1.035" "1.046" "592.5" "613.6" "593.8" "617.9" "620.5" "644.0" "621.1" "676.0" "613.3" "619.6" "" "" "" "" "" "" "" "" "" "" "475.9" "442.8" "471.7" "414.0" "429.1" "483.2" "434.9" "493.7" "613.3" "503.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8095866348413873216" "False" "High" "IsMasterProtein" "Q8WUB8" "PHD finger protein 10 OS=Homo sapiens OX=9606 GN=PHF10 PE=1 SV=3" "0.000" "False" "24.016" "16" "6" "6" "6" "498" "56.0" "6.62" "17.59" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628" "55274" "ENSG00000130024" "PHF10" "hsa:55274; Q2YDA3; Q53HG8; Q8WUB8; Q9BXD2; Q9NV26" "" "" "0" "0" "1.099" "1.107" "0.962" "1.002" "1.068" "1.017" "1.091" "0.977" "1.229" "382.1" "420.0" "423.0" "367.7" "382.8" "408.0" "388.6" "416.8" "373.4" "469.6" "" "" "" "" "" "" "" "" "" "" "306.9" "303.0" "336.0" "246.4" "264.8" "306.1" "272.1" "304.4" "373.4" "381.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2331175161516182807" "False" "High" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "0.000" "False" "24.008" "11" "5" "5" "5" "418" "45.4" "7.99" "19.26" "5" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "1.126" "1.048" "1.007" "1.038" "1.057" "1.003" "1.103" "1.126" "1.128" "392.0" "441.5" "410.6" "394.8" "406.7" "414.4" "393.1" "432.5" "441.2" "442.2" "" "" "" "" "" "" "" "" "" "" "314.8" "318.6" "326.2" "264.5" "281.3" "310.9" "275.2" "315.9" "441.2" "359.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5475559016249233817" "False" "High" "IsMasterProtein" "Q9NVT9" "Armadillo repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=ARMC1 PE=1 SV=1" "0.000" "False" "24.004" "19" "5" "5" "5" "282" "31.3" "5.74" "19.10" "5" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00514" "55156" "ENSG00000104442" "ARMC1" "B4E2W7; hsa:55156; Q9H018; Q9H820; Q9NVT9" "" "" "0" "0" "0.982" "1.072" "1.051" "1.007" "0.935" "0.997" "0.955" "0.951" "0.960" "657.3" "645.4" "704.5" "690.7" "662.2" "614.7" "655.6" "627.4" "625.4" "630.8" "" "" "" "" "" "" "" "" "" "" "527.9" "465.7" "559.6" "462.8" "458.0" "461.2" "459.0" "458.2" "625.4" "513.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6959452537761872804" "False" "High" "IsMasterProtein" "Q8TB45" "DEP domain-containing mTOR-interacting protein OS=Homo sapiens OX=9606 GN=DEPTOR PE=1 SV=2" "0.000" "False" "23.974" "18" "6" "7" "6" "409" "46.3" "8.07" "19.94" "6" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00610" "64798" "ENSG00000155792" "DEPTOR" "B2RCL9; B4DN97; E7EV87; hsa:64798; Q8TB45; Q96EQ1; Q9H0R7; Q9H894; Q9HA07" "" "Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Clear cell renal cell carcinoma pathways; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; ADHD and autism (ASD) linked metabolic pathways and SNP" "10" "0" "1.067" "0.999" "1.145" "1.130" "1.054" "0.957" "0.923" "1.047" "1.184" "224.5" "239.4" "224.3" "256.9" "253.7" "236.5" "214.9" "207.2" "234.9" "265.8" "" "" "" "" "" "" "" "" "" "" "180.3" "172.8" "178.2" "172.1" "175.5" "177.5" "150.5" "151.3" "234.9" "216.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4440624783436864340" "False" "High" "IsMasterProtein" "P01911" "HLA class II histocompatibility antigen, DRB1 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" "0.000" "False" "23.957" "22" "6" "10" "4" "266" "29.9" "7.74" "29.68" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00969, Pf07654" "3123" "ENSG00000196126" "HLA-DRB1" "A0MWF2; A0N0W1; A2ICT1; A2TGX3; A4F5N0; A4ZXA5; A4ZXA6; A4ZY86; A5H000; A5HKN8; A7DZP9; A7LA26; A7UHG2; A7X5B1; A7X5B7; A7X5E0; A7X5E6; A7X5H8; A7X5J4; A7X5K7; A8K098; A8YQE9; A9JPG0; B0BK85; B0LUZ6; B0UYW1; B1GWE7; B2CR03; B2LVF9; B2NJ29; B2ZCY1; B3VTP8; B3VTQ3; B5A8Y2; B5A8Y3; B5B8U0; B5B9V5; B5B9V6; B5LZ25; B5QSK8; B6VCX2; B6VEL9; B7UDB2; B9VRA4; B9X248; C0LAB5; hsa:3123; O02876; O02930; O19585; O19717; O19718; O19739; O19788; O46699; O46793; O46872; O62869; O62889; O77969; O78047; O78210; O98212; P01911; P01912; P01914; P04229; P13758; P13759; P13760; P13761; P20039; P79545; Q06662; Q0PGR5; Q0PQ39; Q14280; Q14QT2; Q155F7; Q19AF2; Q19K86; Q1AP33; Q1G0Z9; Q1JRP3; Q1KLJ6; Q27PR6; Q27PR7; Q29673; Q29720; Q29722; Q29734; Q29770; Q29771; Q29772; Q29790; Q29792; Q29800; Q29806; Q29833; Q29874; Q29875; Q29886; Q29968; Q29974; Q29975; Q2A120; Q2HZE5; Q2L9H4; Q2LE76; Q2MF40; Q2MJA6; Q2MZ92; Q2VQU1; Q2YHQ2; Q30006; Q30108; Q30112; Q30115; Q30116; Q30117; Q30120; Q30134; Q30142; Q30145; Q30149; Q30159; Q30166; Q30167; Q30200; Q307W5; Q31636; Q32MY7; Q3HUP9; Q3KTM1; Q3LA84; Q3LA87; Q3LA88; Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3LA93; Q3LA94; Q3LA95; Q3LA96; Q3LA97; Q3LA98; Q3LA99; Q3LAA0; Q3LAA1; Q3LAA2; Q3MQ60; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7; Q53IG1; Q56FN9; Q56FP1; Q56FP2; Q56FP3; Q58F52; Q5BM92; Q5EER6; Q5K3W2; Q5NDB9; Q5U9W6; Q5UBA2; Q5UT58; Q5W3L4; Q5Y7A7; Q5Y7B0; Q5Y7B9; Q5Y7E9; Q5Y7G0; Q683P7; Q6REE2; Q6T865; Q6U387; Q701T1; Q70GL2; Q70Q85; Q768U2; Q768U4; Q7M2H4; Q7YNY9; Q7YP03; Q7YP04; Q7YQ26; Q7YQA3; Q7YQA5; Q860D8; Q860D9; Q860E5; Q860H8; Q860S0; Q860Z3; Q861G6; Q861H0; Q861H4; Q861H5; Q861H7; Q861H8; Q8HWQ6; Q8MH59; Q8MH60; Q8WLU3; Q8WMA0; Q95348; Q95383; Q95389; Q95461; Q95HK1; Q95HL0; Q95HL1; Q95IE3; Q95IG2; Q95IT6; Q96HZ9; Q9BCL7; Q9BCP0; Q9BCP1; Q9BCP2; Q9BCP5; Q9BD21; Q9BD33; Q9BD40; Q9GIK5; Q9GIL5; Q9GIL6; Q9GIP3; Q9GIX8; Q9GIX9; Q9GIY0; Q9GIY1; Q9GIY2; Q9GIY3; Q9GIY4; Q9GJ25; Q9GJ56; Q9GJ57; Q9GJ58; Q9GJ60; Q9GJF8; Q9GJF9; Q9GJG0; Q9MXZ0; Q9MXZ5; Q9MY13; Q9MY45; Q9MY56; Q9MYF5; Q9TPB6; Q9TPW1; Q9TPW3; Q9TPW9; Q9TPX4; Q9TQ37; Q9TQ91; Q9TQE0; Q9UBY1; Q9UIM9; Q9UIN0; Q9XRX1; Q9XRY4; Q9XRY5; Q9Y453; Q9Y4H7" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; Primary ovarian insufficiency" "17" "0" "0.908" "0.985" "0.926" "1.036" "1.063" "1.130" "0.961" "1.026" "1.057" "367.9" "334.2" "362.2" "340.6" "381.2" "391.1" "415.7" "353.5" "377.5" "389.0" "" "" "" "" "" "" "" "" "" "" "295.5" "241.1" "287.7" "228.2" "263.7" "293.4" "291.1" "258.2" "377.5" "316.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543040224215837261" "False" "High" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "0.000" "False" "23.950" "32" "7" "9" "7" "203" "23.8" "9.26" "28.78" "7" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "1.054" "1.137" "1.167" "1.131" "1.132" "1.236" "1.128" "1.147" "1.130" "664.2" "699.8" "755.1" "775.1" "751.0" "751.9" "820.8" "749.3" "761.6" "750.7" "" "" "" "" "" "" "" "" "" "" "533.4" "504.9" "599.8" "519.3" "519.4" "564.1" "574.7" "547.2" "761.6" "610.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3954168667574221268" "False" "High" "IsMasterProtein" "Q9H1J1" "Regulator of nonsense transcripts 3A OS=Homo sapiens OX=9606 GN=UPF3A PE=1 SV=1" "0.000" "False" "23.940" "11" "5" "7" "5" "476" "54.7" "9.03" "18.97" "5" "transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65110" "ENSG00000169062" "UPF3A" "A2A366; hsa:65110; Q5T8C3; Q5T8C9; Q7Z6N3; Q86YK1; Q9BZI8; Q9H1J1" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "2" "0" "0.883" "0.933" "0.958" "0.879" "0.991" "1.031" "0.856" "0.895" "0.918" "267.8" "236.6" "249.8" "256.5" "235.4" "265.3" "276.1" "229.2" "239.7" "245.8" "" "" "" "" "" "" "" "" "" "" "215.1" "170.7" "198.4" "171.9" "162.8" "199.1" "193.3" "167.4" "239.7" "199.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4056526521297064515" "False" "High" "IsMasterProtein" "Q14690" "Protein RRP5 homolog OS=Homo sapiens OX=9606 GN=PDCD11 PE=1 SV=3" "0.000" "False" "23.938" "4" "6" "7" "6" "1871" "208.6" "8.87" "18.75" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00575, Pf05843" "22984" "ENSG00000148843" "PDCD11" "hsa:22984; Q14690; Q2TA92; Q5W093; Q6P2J3; Q86VQ8; Q9H4P1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.066" "1.302" "1.300" "1.227" "1.366" "1.288" "1.200" "1.093" "1.254" "176.9" "188.5" "230.3" "230.0" "217.0" "241.7" "227.9" "212.3" "193.4" "221.8" "" "" "" "" "" "" "" "" "" "" "142.1" "136.0" "182.9" "154.1" "150.1" "181.3" "159.6" "155.0" "193.4" "180.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8117558468974038429" "False" "High" "IsMasterProtein" "Q96Q11" "CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2" "0.000" "False" "23.936" "12" "6" "10" "6" "434" "50.1" "8.10" "31.09" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01743, Pf12627" "51095" "ENSG00000072756" "TRNT1" "A8K2Z6; B7WP13; C9JKA2; hsa:51095; Q8ND57; Q96Q11; Q9BS97; Q9Y362" "tRNA processing in the nucleus; tRNA processing in the mitochondrion" "" "2" "0" "0.963" "1.000" "1.004" "0.974" "1.042" "1.224" "0.899" "0.886" "0.941" "1236.9" "1191.0" "1236.4" "1242.1" "1205.2" "1289.3" "1514.1" "1111.9" "1095.7" "1163.8" "" "" "" "" "" "" "" "" "" "" "993.5" "859.4" "982.1" "832.2" "833.5" "967.4" "1060.1" "812.0" "1095.7" "946.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7745810489150015985" "False" "High" "IsMasterProtein" "O95292" "Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3" "0.000" "False" "23.933" "17" "4" "8" "3" "243" "27.2" "7.30" "29.33" "4" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9217" "ENSG00000124164" "VAPB" "A2A2F2; hsa:9217; O95292; O95293; Q9P0H0" "Sphingolipid de novo biosynthesis; RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle" "Ciliary landscape" "7" "1" "1.005" "0.899" "0.947" "0.896" "0.956" "0.970" "1.020" "1.016" "0.930" "596.5" "599.2" "536.2" "564.7" "534.5" "570.2" "578.4" "608.7" "606.3" "554.9" "" "" "" "" "" "" "" "" "" "" "479.1" "432.4" "425.9" "378.3" "369.6" "427.8" "405.0" "444.5" "606.3" "451.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6133561671554163995" "False" "High" "IsMasterProtein" "P43378" "Tyrosine-protein phosphatase non-receptor type 9 OS=Homo sapiens OX=9606 GN=PTPN9 PE=1 SV=1" "0.000" "False" "23.914" "13" "8" "8" "8" "593" "68.0" "8.02" "25.02" "8" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00102, Pf00650" "5780" "ENSG00000169410" "PTPN9" "hsa:5780; P43378; Q53XR9" "Interleukin-37 signaling" "VEGFA-VEGFR2 signaling" "2" "0" "0.969" "0.981" "0.947" "0.997" "1.003" "0.993" "1.005" "0.974" "0.904" "625.4" "605.8" "613.4" "592.1" "623.5" "627.0" "620.9" "628.4" "609.0" "565.0" "" "" "" "" "" "" "" "" "" "" "502.3" "437.1" "487.2" "396.7" "431.2" "470.4" "434.7" "458.9" "609.0" "459.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5875198809388005970" "False" "High" "IsMasterProtein" "Q9H3H3" "UPF0696 protein C11orf68 OS=Homo sapiens OX=9606 GN=C11orf68 PE=1 SV=3" "0.000" "False" "23.910" "19" "5" "5" "5" "292" "31.4" "6.32" "19.95" "5" "" "" "" "Pf08939" "83638" "ENSG00000175573" "C11orf68" "hsa:83638; J3KQG9; Q9BT13; Q9H3H3" "" "" "0" "0" "1.012" "0.984" "1.103" "1.111" "1.088" "1.095" "1.104" "1.041" "1.109" "299.3" "302.8" "294.5" "330.2" "332.4" "325.6" "327.8" "330.4" "311.4" "331.9" "" "" "" "" "" "" "" "" "" "" "240.4" "218.5" "233.9" "221.2" "229.9" "244.3" "229.5" "241.3" "311.4" "269.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2919844003918088189" "False" "High" "IsMasterProtein" "Q9P215" "Pogo transposable element with KRAB domain OS=Homo sapiens OX=9606 GN=POGK PE=1 SV=2" "0.000" "False" "23.842" "10" "5" "6" "5" "609" "69.4" "5.14" "15.12" "5" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf01352, Pf03184, Pf03221, Pf09607" "57645" "ENSG00000143157" "POGK" "hsa:57645; Q5TIJ1; Q8TE07; Q9P215" "" "" "0" "0" "0.991" "1.030" "0.945" "1.026" "1.029" "0.925" "1.016" "1.054" "1.062" "515.4" "510.8" "530.9" "487.1" "528.9" "530.2" "476.9" "523.7" "543.0" "547.1" "" "" "" "" "" "" "" "" "" "" "414.0" "368.5" "421.7" "326.4" "365.8" "397.8" "333.9" "382.4" "543.0" "445.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8244788051015200479" "False" "High" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "0.000" "False" "23.837" "29" "6" "15" "5" "177" "19.2" "8.07" "33.36" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "" "2" "0" "0.969" "0.914" "0.942" "1.036" "0.983" "1.030" "0.967" "0.874" "0.941" "1192.0" "1154.5" "1090.0" "1122.7" "1235.0" "1171.9" "1228.3" "1152.8" "1041.6" "1121.5" "" "" "" "" "" "" "" "" "" "" "957.4" "833.0" "865.8" "752.2" "854.1" "879.3" "860.0" "841.9" "1041.6" "912.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657158777638447925" "False" "High" "IsMasterProtein" "P20273" "B-cell receptor CD22 OS=Homo sapiens OX=9606 GN=CD22 PE=1 SV=2" "0.000" "False" "23.825" "6" "4" "4" "4" "847" "95.3" "6.65" "16.76" "4" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08205, Pf13895, Pf13927" "933" "ENSG00000012124" "CD22" "F5GYU4; F5H7U3; hsa:933; O95699; O95701; O95702; O95703; P20273; Q01665; Q32M46; Q92872; Q92873; Q9UQA6; Q9UQA7; Q9UQA8; Q9UQA9; Q9UQB0; Q9Y2A6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "5" "0" "0.977" "0.938" "0.988" "1.058" "1.116" "1.053" "0.901" "1.061" "1.033" "325.9" "318.3" "305.8" "321.9" "344.8" "363.6" "343.1" "293.8" "345.7" "336.8" "" "" "" "" "" "" "" "" "" "" "261.8" "229.7" "242.9" "215.7" "238.5" "272.8" "240.2" "214.5" "345.7" "273.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7689745804882425318" "False" "High" "IsMasterProtein" "Q6XQN6" "Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2" "0.000" "False" "23.732" "9" "4" "5" "4" "538" "57.5" "5.68" "19.64" "4" "other metabolic processes;stress response" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf17767, Pf17956" "93100" "ENSG00000147813; ENSG00000278488" "NAPRT" "A7BFI3; hsa:93100; Q6PJL1; Q6XQN4; Q6XQN5; Q6XQN6; Q8N5E8; Q9BRG0" "Neutrophil degranulation; Nicotinamide salvaging" "NAD+ biosynthetic pathways" "3" "0" "1.019" "1.028" "1.090" "1.049" "1.026" "1.064" "0.930" "1.087" "1.025" "563.8" "574.6" "579.8" "614.7" "591.6" "578.4" "600.2" "524.2" "612.6" "577.7" "" "" "" "" "" "" "" "" "" "" "452.9" "414.6" "460.6" "411.8" "409.1" "433.9" "420.2" "382.8" "612.6" "469.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1761615694951134021" "False" "High" "IsMasterProtein" "P62888" "Large ribosomal subunit protein eL30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "0.000" "False" "23.706" "39" "4" "7" "4" "115" "12.8" "9.63" "18.50" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Selenium metabolism and selenoproteins; Cytoplasmic ribosomal proteins" "15" "0" "1.062" "1.082" "1.092" "1.057" "0.937" "1.142" "0.970" "1.025" "1.089" "337.0" "358.1" "364.7" "368.1" "356.2" "315.8" "384.8" "326.8" "345.5" "366.9" "" "" "" "" "" "" "" "" "" "" "270.7" "258.4" "289.7" "246.6" "246.4" "236.9" "269.4" "238.7" "345.5" "298.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6220946712320524294" "False" "High" "IsMasterProtein" "Q7L5D6" "Golgi to ER traffic protein 4 homolog OS=Homo sapiens OX=9606 GN=GET4 PE=1 SV=1" "0.000" "False" "23.677" "21" "7" "8" "7" "327" "36.5" "5.41" "22.87" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04190" "51608" "ENSG00000239857" "GET4" "A4D2Q1; B3KNC7; hsa:51608; Q7L5D6; Q9UFC9; Q9Y309" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "1.029" "0.949" "0.904" "0.953" "0.909" "0.826" "0.973" "0.953" "0.928" "320.6" "330.0" "304.2" "289.8" "305.7" "291.4" "264.9" "312.0" "305.4" "297.4" "" "" "" "" "" "" "" "" "" "" "257.5" "238.2" "241.7" "194.2" "211.4" "218.6" "185.5" "227.8" "305.4" "241.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8764284085983728716" "False" "High" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0.000" "False" "23.675" "2" "4" "4" "4" "2426" "263.7" "5.64" "17.06" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "1.146" "1.025" "1.101" "1.157" "1.091" "1.077" "1.237" "1.253" "1.141" "438.8" "502.9" "450.0" "483.0" "507.5" "479.0" "472.8" "542.7" "550.0" "500.8" "" "" "" "" "" "" "" "" "" "" "352.5" "362.8" "357.5" "323.6" "351.0" "359.4" "331.1" "396.4" "550.0" "407.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3992202401745413050" "False" "High" "IsMasterProtein" "O75044" "SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3" "0.000" "False" "23.642" "6" "5" "5" "5" "1071" "120.8" "6.70" "14.74" "5" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00611, Pf00620" "23380" "ENSG00000266028" "SRGAP2" "A2RUF3; hsa:23380; O75044" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate Formins; RAC3 GTPase cycle; RHOF GTPase cycle; RHOU GTPase cycle; Inactivation of CDC42 and RAC1" "" "8" "0" "1.360" "1.151" "1.363" "1.129" "1.116" "1.225" "0.985" "1.173" "1.016" "71.8" "97.7" "82.6" "97.9" "81.1" "80.2" "87.9" "70.7" "84.2" "73.0" "" "" "" "" "" "" "" "" "" "" "57.7" "70.5" "65.7" "65.6" "56.1" "60.1" "61.6" "51.7" "84.2" "59.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213729863308039280" "False" "High" "IsMasterProtein" "Q14331" "Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1" "0.000" "False" "23.625" "25" "6" "7" "6" "258" "29.2" "9.01" "22.62" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf06229" "2483" "ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630" "FRG1" "A8K775; hsa:2483; Q14331" "" "" "0" "0" "0.959" "0.980" "1.019" "0.966" "0.981" "0.975" "0.890" "0.962" "0.948" "930.0" "891.9" "911.3" "947.9" "898.7" "912.0" "906.8" "827.9" "894.3" "881.3" "" "" "" "" "" "" "" "" "" "" "747.0" "643.6" "723.9" "635.1" "621.6" "684.3" "634.9" "604.6" "894.3" "716.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196663768808374141" "False" "High" "IsMasterProtein" "Q9UBP6" "tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens OX=9606 GN=METTL1 PE=1 SV=1" "0.000" "False" "23.571" "16" "3" "5" "3" "276" "31.5" "7.64" "16.14" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02390" "4234" "ENSG00000037897" "METTL1" "B2RBX1; H7BXF2; hsa:4234; Q14105; Q53FS9; Q9UBP6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.040" "1.130" "1.052" "1.118" "1.142" "0.981" "1.122" "1.086" "0.984" "186.8" "194.3" "211.2" "196.5" "208.9" "213.4" "183.3" "209.6" "202.9" "183.8" "" "" "" "" "" "" "" "" "" "" "150.0" "140.2" "167.7" "131.7" "144.5" "160.1" "128.3" "153.0" "202.9" "149.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3621833610637206208" "False" "High" "IsMasterProtein" "Q92623" "Tetratricopeptide repeat protein 9A OS=Homo sapiens OX=9606 GN=TTC9 PE=1 SV=3" "0.000" "False" "23.567" "14" "3" "4" "3" "222" "24.4" "8.98" "16.12" "3" "developmental processes" "" "" "" "23508" "ENSG00000133985" "TTC9" "hsa:23508; Q86WT2; Q92623" "" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "1" "0" "1.015" "0.987" "0.946" "0.914" "1.027" "0.977" "0.928" "0.963" "1.007" "358.8" "364.1" "354.0" "339.4" "328.0" "368.6" "350.6" "332.8" "345.4" "361.2" "" "" "" "" "" "" "" "" "" "" "288.1" "262.7" "281.2" "227.4" "226.8" "276.6" "245.5" "243.0" "345.4" "293.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951655110054191757" "False" "High" "IsMasterProtein" "Q5VW32" "BRO1 domain-containing protein BROX OS=Homo sapiens OX=9606 GN=BROX PE=1 SV=1" "0.000" "False" "23.566" "15" "5" "7" "5" "411" "46.4" "7.65" "26.93" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;nucleus" "" "Pf03097" "148362" "ENSG00000162819" "BROX" "B7Z9G5; hsa:148362; Q5VW32; Q96MG1" "" "" "0" "0" "0.976" "1.018" "0.980" "0.988" "0.935" "0.934" "0.898" "0.906" "0.959" "774.1" "755.5" "788.3" "758.5" "764.8" "723.9" "723.3" "695.5" "701.6" "742.5" "" "" "" "" "" "" "" "" "" "" "621.8" "545.1" "626.2" "508.2" "529.0" "543.1" "506.4" "507.9" "701.6" "603.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6221912277285666984" "False" "High" "IsMasterProtein" "Q5TC12" "ATP synthase mitochondrial F1 complex assembly factor 1 OS=Homo sapiens OX=9606 GN=ATPAF1 PE=1 SV=1" "0.000" "False" "23.519" "17" "4" "5" "4" "328" "36.4" "7.96" "19.66" "4" "cell organization and biogenesis" "mitochondrion" "" "Pf06644" "64756" "ENSG00000123472" "ATPAF1" "B1AQW7; B7Z7D6; B7Z7I6; hsa:64756; Q5TC12; Q9H6E3" "" "7q11.23 copy number variation syndrome" "1" "0" "1.003" "0.868" "1.074" "1.109" "1.090" "0.975" "1.095" "1.004" "1.033" "226.2" "226.8" "196.4" "243.0" "250.8" "246.6" "220.7" "247.7" "227.1" "233.8" "" "" "" "" "" "" "" "" "" "" "181.7" "163.7" "156.0" "162.8" "173.5" "185.0" "154.5" "180.9" "227.1" "190.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428754804967895147" "False" "High" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "0.000" "False" "23.503" "23" "4" "6" "3" "172" "19.5" "6.34" "21.83" "4" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "0.929" "1.023" "0.929" "0.925" "0.949" "0.924" "0.977" "0.947" "0.896" "330.4" "307.0" "338.0" "307.1" "305.7" "313.6" "305.5" "322.8" "313.0" "296.0" "" "" "" "" "" "" "" "" "" "" "265.4" "221.5" "268.5" "205.8" "211.4" "235.3" "213.9" "235.7" "313.0" "240.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841037560780449706" "False" "High" "IsMasterProtein" "O43663" "Protein regulator of cytokinesis 1 OS=Homo sapiens OX=9606 GN=PRC1 PE=1 SV=2" "0.000" "False" "23.492" "13" "8" "8" "7" "620" "71.6" "6.68" "24.39" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03999" "9055" "ENSG00000198901" "PRC1" "A6NC44; B4DLR1; H9KV59; hsa:9055; O43663; Q9BSB6" "RHO GTPases activate CIT" "" "1" "0" "0.986" "1.005" "0.978" "0.983" "1.055" "1.126" "1.248" "1.231" "1.066" "657.1" "647.6" "660.5" "642.8" "646.2" "693.3" "739.9" "819.8" "808.8" "700.8" "" "" "" "" "" "" "" "" "" "" "527.8" "467.3" "524.7" "430.6" "446.9" "520.2" "518.0" "598.7" "808.8" "569.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2630091394541072843" "False" "High" "IsMasterProtein" "Q9P2Y5" "UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1" "0.000" "False" "23.484" "9" "7" "10" "7" "699" "78.1" "8.29" "26.50" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf10186" "7405" "ENSG00000198382" "UVRAG" "B3KTC1; hsa:7405; O00392; Q9P2Y5" "Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; SARS-CoV-2 modulates autophagy" "Nanoparticle triggered autophagic cell death; Autophagy" "6" "0" "0.893" "0.916" "0.961" "0.843" "0.866" "0.815" "0.875" "0.889" "0.873" "541.1" "483.1" "495.9" "519.9" "456.0" "468.5" "441.1" "473.7" "480.9" "472.6" "" "" "" "" "" "" "" "" "" "" "434.6" "348.6" "393.9" "348.3" "315.4" "351.5" "308.9" "346.0" "480.9" "384.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1639956808395934598" "False" "High" "IsMasterProtein" "Q9UKT4" "F-box only protein 5 OS=Homo sapiens OX=9606 GN=FBXO5 PE=1 SV=1" "0.000" "False" "23.479" "13" "5" "7" "5" "447" "50.1" "8.92" "23.92" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00646" "26271" "ENSG00000112029" "FBXO5" "B3KNX5; hsa:26271; Q5TF47; Q8WV29; Q9UGC8; Q9UKT4" "SCF-beta-TrCP mediated degradation of Emi1; G1/S-Specific Transcription; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "" "5" "0" "0.963" "0.886" "0.946" "0.898" "0.918" "1.268" "1.338" "1.394" "1.046" "422.8" "407.1" "374.7" "400.1" "379.9" "388.3" "536.2" "565.8" "589.2" "442.1" "" "" "" "" "" "" "" "" "" "" "339.6" "293.7" "297.6" "268.1" "262.7" "291.3" "375.4" "413.2" "589.2" "359.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6159664741780628895" "False" "High" "IsMasterProtein" "Q9P2K3" "REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2" "0.000" "False" "23.474" "10" "5" "7" "3" "495" "55.5" "8.27" "22.88" "5" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "55758" "ENSG00000117625" "RCOR3" "B3KYA2; B4DYY7; hsa:55758; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83; Q9P2K3" "" "" "0" "0" "0.852" "0.672" "0.709" "0.819" "0.793" "0.849" "0.784" "0.756" "0.795" "154.2" "131.4" "103.6" "109.3" "126.3" "122.3" "131.0" "120.9" "116.6" "122.7" "" "" "" "" "" "" "" "" "" "" "123.9" "94.8" "82.3" "73.2" "87.3" "91.8" "91.7" "88.3" "116.6" "99.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9193624318579361527" "False" "High" "IsMasterProtein" "Q9UGI8" "Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1" "0.000" "False" "23.465" "19" "6" "6" "6" "421" "48.0" "7.68" "18.71" "6" "other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412, Pf06297" "26136" "ENSG00000135269" "TES" "A4D0U6; hsa:26136; Q9GZQ1; Q9HAJ9; Q9UGI8" "" "" "0" "0" "0.979" "1.023" "1.079" "1.043" "0.992" "1.082" "0.940" "1.023" "1.054" "175.6" "172.0" "179.6" "189.4" "183.1" "174.2" "190.1" "165.1" "179.7" "185.1" "" "" "" "" "" "" "" "" "" "" "141.0" "124.1" "142.7" "126.9" "126.6" "130.7" "133.1" "120.6" "179.7" "150.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5653084663226725114" "False" "High" "IsMasterProtein" "Q96JJ3" "Engulfment and cell motility protein 2 OS=Homo sapiens OX=9606 GN=ELMO2 PE=1 SV=2" "0.000" "False" "23.429" "8" "7" "10" "2" "720" "82.6" "5.90" "26.26" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf04727, Pf11841, Pf16457" "63916" "ENSG00000062598" "ELMO2" "E1P5T3; hsa:63916; Q5JVZ6; Q7Z5G9; Q96CJ2; Q96JJ3; Q96ME5; Q96PA9; Q9H938; Q9H9L5; Q9HAH0; Q9NQQ6" "RHOG GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7384087443166083849" "False" "High" "IsMasterProtein" "O14562" "Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens OX=9606 GN=UBFD1 PE=1 SV=2" "0.000" "False" "23.425" "7" "2" "4" "2" "309" "33.4" "5.77" "15.92" "2" "" "" "" "Pf00240" "56061" "ENSG00000103353" "UBFD1" "A8MW58; D3DWF2; hsa:56061; O14562" "" "" "0" "0" "0.967" "0.966" "1.028" "0.929" "0.971" "0.965" "0.966" "0.958" "0.906" "436.6" "422.2" "421.7" "449.0" "405.5" "423.9" "421.3" "421.8" "418.3" "395.8" "" "" "" "" "" "" "" "" "" "" "350.7" "304.7" "335.0" "300.8" "280.4" "318.0" "295.0" "308.1" "418.3" "321.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141064915599705120" "False" "High" "IsMasterProtein" "Q9P000" "COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2" "0.000" "False" "23.413" "18" "4" "5" "4" "198" "21.8" "5.88" "19.01" "4" "transport;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf07258, Pf20923" "29099" "ENSG00000110442" "COMMD9" "E9PAN2; hsa:29099; Q96FI2; Q9H0R0; Q9P000" "Neddylation; Neutrophil degranulation" "" "2" "0" "1.136" "1.018" "1.143" "1.108" "1.022" "1.054" "1.010" "1.008" "1.002" "332.0" "377.2" "338.1" "379.6" "367.9" "339.4" "349.9" "335.3" "334.6" "332.8" "" "" "" "" "" "" "" "" "" "" "266.6" "272.2" "268.6" "254.3" "254.4" "254.7" "245.0" "244.8" "334.6" "270.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8481325661535348808" "False" "High" "IsMasterProtein" "P46019" "Phosphorylase b kinase regulatory subunit alpha, liver isoform OS=Homo sapiens OX=9606 GN=PHKA2 PE=1 SV=1" "0.000" "False" "23.408" "5" "5" "6" "5" "1235" "138.3" "6.44" "20.22" "5" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00723, Pf19292" "5256" "ENSG00000044446" "PHKA2" "A8K1T1; hsa:5256; P46019; Q6LAJ5; Q7Z6W0; Q96CR3; Q9UDA1" "Glycogen breakdown (glycogenolysis)" "Type II diabetes mellitus; Glycogen synthesis and degradation" "3" "0" "1.372" "1.150" "1.184" "1.174" "1.287" "1.282" "1.230" "1.199" "1.300" "52.8" "72.5" "60.8" "62.6" "62.0" "68.0" "67.7" "65.0" "63.3" "68.7" "" "" "" "" "" "" "" "" "" "" "42.4" "52.3" "48.3" "41.9" "42.9" "51.0" "47.4" "47.5" "63.3" "55.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153257875265109999" "False" "High" "IsMasterProtein" "Q9NYJ1" "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2" "0.000" "False" "23.400" "37" "3" "5" "3" "87" "10.1" "6.04" "22.61" "3" "cell organization and biogenesis" "mitochondrion" "" "Pf06747" "51287" "ENSG00000181924" "COA4" "B2RAA0; hsa:51287; Q69YU4; Q9NYJ1" "Mitochondrial protein import" "" "1" "0" "1.036" "1.020" "1.083" "0.990" "1.104" "1.027" "1.114" "1.030" "1.008" "584.8" "605.9" "596.7" "633.6" "578.9" "645.7" "600.7" "651.5" "602.4" "589.4" "" "" "" "" "" "" "" "" "" "" "469.7" "437.2" "474.0" "424.5" "400.3" "484.5" "420.6" "475.8" "602.4" "479.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711038865420362592" "False" "High" "IsMasterProtein" "Q9BRV8" "Suppressor of IKBKE 1 OS=Homo sapiens OX=9606 GN=SIKE1 PE=1 SV=1" "0.000" "False" "23.394" "31" "4" "4" "4" "207" "23.7" "5.21" "18.59" "4" "" "cytosol" "other molecular function" "Pf05769" "80143" "ENSG00000052723" "SIKE1" "hsa:80143; Q5TEZ7; Q5TEZ9; Q68DZ4; Q9BRV8; Q9H778" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation" "Novel intracellular components of RIG-I-like receptor pathway" "5" "0" "0.970" "0.915" "1.057" "1.071" "1.002" "1.077" "1.094" "1.066" "1.028" "215.4" "208.9" "197.1" "227.6" "230.7" "215.8" "231.8" "235.6" "229.5" "221.4" "" "" "" "" "" "" "" "" "" "" "173.0" "150.8" "156.6" "152.5" "159.5" "161.9" "162.3" "172.1" "229.5" "180.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4219070174713908542" "False" "High" "IsMasterProtein" "P04049" "RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1" "0.000" "False" "23.368" "7" "5" "6" "2" "648" "73.0" "9.20" "18.22" "5" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf02196" "5894" "ENSG00000132155" "RAF1" "B0LPH8; B2R5N3; hsa:5894; P04049; Q15278; Q9UC20" "Rap1 signalling; Stimuli-sensing channels; Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; CD209 (DC-SIGN) signaling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Negative feedback regulation of MAPK pathway" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; Fragile X syndrome; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; 7q11.23 distal copy number variation; 15q25 copy number variation; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "104" "0" "0.969" "0.956" "1.139" "0.939" "0.847" "0.997" "0.952" "0.963" "0.962" "95.2" "92.2" "91.0" "108.4" "89.4" "80.6" "94.9" "90.6" "91.7" "91.6" "" "" "" "" "" "" "" "" "" "" "76.5" "66.5" "72.3" "72.7" "61.8" "60.5" "66.4" "66.2" "91.7" "74.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850217669682801799" "False" "High" "IsMasterProtein" "Q9NZD8" "Maspardin OS=Homo sapiens OX=9606 GN=SPG21 PE=1 SV=1" "0.000" "False" "23.343" "18" "5" "6" "5" "308" "34.9" "6.28" "20.01" "5" "signal transduction" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf00561" "51324" "ENSG00000090487" "SPG21" "B4DW44; Q6ZMB6; Q9NZD8" "" "" "0" "0" "0.917" "0.983" "0.996" "0.935" "0.992" "0.963" "0.997" "0.945" "0.973" "506.5" "464.6" "497.8" "504.7" "473.8" "502.2" "487.8" "505.1" "478.8" "492.7" "" "" "" "" "" "" "" "" "" "" "406.8" "335.2" "395.4" "338.1" "327.7" "376.8" "341.5" "368.9" "478.8" "400.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7226470696601852520" "False" "High" "IsMasterProtein" "Q9H0A8" "COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1" "0.000" "False" "23.339" "23" "5" "7" "5" "199" "21.8" "7.31" "19.18" "5" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf07258, Pf21672" "54939" "ENSG00000140365" "COMMD4" "B2RBN4; H3BUL2; hsa:54939; Q7L637; Q9H0A8; Q9NX43" "Neddylation" "" "1" "0" "1.100" "1.010" "1.051" "0.976" "1.192" "0.986" "1.032" "1.022" "1.025" "459.5" "505.2" "464.1" "482.8" "448.2" "547.5" "453.2" "474.2" "469.7" "471.1" "" "" "" "" "" "" "" "" "" "" "369.0" "364.5" "368.6" "323.5" "310.0" "410.8" "317.3" "346.3" "469.7" "383.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7763347901800507563" "False" "High" "IsMasterProtein" "Q9HB19" "Pleckstrin homology domain-containing family A member 2 OS=Homo sapiens OX=9606 GN=PLEKHA2 PE=1 SV=3" "0.000" "False" "23.324" "10" "4" "6" "4" "425" "47.2" "8.66" "21.97" "4" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00169" "59339" "ENSG00000169499" "PLEKHA2" "A8K727; hsa:59339; Q9HB19" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "0.987" "0.915" "0.963" "1.014" "0.967" "0.988" "1.051" "1.049" "1.027" "515.5" "508.9" "471.7" "496.6" "522.6" "498.4" "509.2" "541.9" "540.9" "529.6" "" "" "" "" "" "" "" "" "" "" "414.1" "367.2" "374.7" "332.7" "361.4" "374.0" "356.5" "395.8" "540.9" "430.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4009101809611603487" "False" "High" "IsMasterProtein" "Q9NUW8" "Tyrosyl-DNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=TDP1 PE=1 SV=2" "0.000" "False" "23.308" "5" "3" "4" "3" "608" "68.4" "7.65" "17.47" "3" "DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06087" "55775" "ENSG00000042088" "TDP1" "hsa:55775; Q2HXX4; Q86TV8; Q96BK7; Q9NUW8; Q9NZM7; Q9NZM8" "Nonhomologous End-Joining (NHEJ)" "" "1" "0" "1.064" "1.034" "1.032" "0.979" "1.152" "0.950" "0.947" "0.935" "0.990" "546.0" "580.7" "564.7" "563.5" "534.7" "629.1" "518.6" "517.2" "510.6" "540.7" "" "" "" "" "" "" "" "" "" "" "438.5" "419.0" "448.6" "377.6" "369.8" "472.0" "363.1" "377.7" "510.6" "439.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630318732500359632" "False" "High" "IsMasterProtein" "P62280" "Small ribosomal subunit protein uS17 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "0.000" "False" "23.246" "30" "6" "8" "6" "158" "18.4" "10.30" "26.42" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "SARS-CoV-2 modulates host translation machinery; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "21" "0" "1.013" "1.208" "1.034" "1.085" "1.068" "1.071" "1.173" "1.103" "1.086" "934.0" "946.4" "1128.4" "966.0" "1013.4" "997.8" "1000.5" "1095.5" "1030.6" "1013.9" "" "" "" "" "" "" "" "" "" "" "750.2" "682.9" "896.4" "647.2" "700.9" "748.6" "700.5" "800.0" "1030.6" "824.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1584990058854155939" "False" "High" "IsMasterProtein" "Q9NPI6" "mRNA-decapping enzyme 1A OS=Homo sapiens OX=9606 GN=DCP1A PE=1 SV=3" "0.000" "False" "23.229" "14" "6" "7" "6" "582" "63.2" "6.25" "17.74" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "55802" "ENSG00000272886" "DCP1A" "B4DHN9; hsa:55802; Q9NPI6; U3KQM8" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; mRNA decay by 5' to 3' exoribonuclease; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "TGF-beta signaling pathway" "5" "0" "0.962" "0.958" "1.028" "1.040" "0.971" "1.066" "1.063" "0.980" "0.956" "539.0" "518.4" "516.5" "554.2" "560.6" "523.2" "574.7" "573.2" "528.4" "515.0" "" "" "" "" "" "" "" "" "" "" "432.9" "374.0" "410.3" "371.3" "387.7" "392.5" "402.4" "418.6" "528.4" "418.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1227162241055397784" "False" "High" "IsMasterProtein" "Q9H0W8" "Nonsense-mediated mRNA decay factor SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1" "0.000" "False" "23.224" "10" "4" "7" "4" "520" "57.6" "7.01" "16.87" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "" "56006" "ENSG00000105771" "SMG9" "hsa:56006; O60429; Q9H0W8; Q9H9A9" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "0.926" "0.951" "0.988" "1.114" "1.029" "1.086" "1.045" "0.977" "1.034" "365.4" "338.4" "347.6" "361.2" "407.2" "375.9" "397.0" "381.8" "357.0" "378.0" "" "" "" "" "" "" "" "" "" "" "293.5" "244.2" "276.1" "242.0" "281.6" "282.0" "277.9" "278.8" "357.0" "307.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2093622572460603588" "False" "High" "IsMasterProtein" "Q8NBF6" "Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1" "0.000" "False" "23.217" "9" "6" "7" "6" "648" "71.9" "6.21" "20.25" "6" "other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf09794" "23080" "ENSG00000105778" "AVL9" "hsa:23080; Q8NBF6; Q92573" "" "" "0" "0" "0.916" "0.974" "1.133" "0.987" "1.006" "1.000" "0.998" "1.024" "0.986" "520.9" "477.1" "507.2" "590.0" "513.9" "524.0" "520.7" "519.7" "533.3" "513.8" "" "" "" "" "" "" "" "" "" "" "418.4" "344.3" "402.9" "395.3" "355.4" "393.1" "364.6" "379.5" "533.3" "417.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-218313334757402260" "False" "High" "IsMasterProtein" "A6NFI3" "Zinc finger protein 316 OS=Homo sapiens OX=9606 GN=ZNF316 PE=1 SV=1" "0.000" "False" "23.215" "4" "4" "5" "4" "1004" "108.4" "5.31" "17.64" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "100131017" "ENSG00000205903" "ZNF316" "A6NFI3" "" "" "0" "0" "1.105" "1.106" "1.126" "1.062" "1.032" "1.048" "1.085" "1.110" "1.101" "421.1" "465.2" "465.8" "474.1" "447.2" "434.4" "441.5" "456.9" "467.5" "463.5" "" "" "" "" "" "" "" "" "" "" "338.2" "335.7" "370.0" "317.6" "309.3" "325.9" "309.1" "333.6" "467.5" "376.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5403362594162546688" "False" "High" "IsMasterProtein" "Q15007" "Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2" "0.000" "False" "23.187" "16" "5" "7" "5" "396" "44.2" "5.19" "18.63" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf17098" "9589" "ENSG00000146457" "WTAP" "hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2" "Processing of Capped Intron-Containing Pre-mRNA" "" "1" "0" "0.981" "1.015" "1.039" "0.975" "1.036" "1.043" "1.003" "0.987" "0.998" "549.4" "538.9" "557.5" "570.9" "535.9" "569.3" "573.2" "550.8" "542.2" "548.3" "" "" "" "" "" "" "" "" "" "" "441.3" "388.8" "442.9" "382.5" "370.6" "427.1" "401.3" "402.2" "542.2" "445.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3735327687387277491" "False" "High" "IsMasterProtein" "Q16254" "Transcription factor E2F4 OS=Homo sapiens OX=9606 GN=E2F4 PE=1 SV=2" "0.000" "False" "23.173" "16" "7" "7" "5" "413" "43.9" "4.75" "22.73" "7" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1874" "ENSG00000205250" "E2F4" "A6NGR8; B5BU56; hsa:1874; Q12991; Q15328; Q16254" "G1/S-Specific Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; Alstrom syndrome" "14" "1" "0.976" "0.973" "1.053" "0.965" "0.979" "0.940" "0.855" "0.965" "0.991" "669.4" "653.3" "651.0" "704.8" "645.8" "655.3" "629.4" "572.3" "646.2" "663.6" "" "" "" "" "" "" "" "" "" "" "537.7" "471.4" "517.1" "472.2" "446.7" "491.6" "440.7" "417.9" "646.2" "539.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3433213539616798007" "False" "High" "IsMasterProtein" "Q9P2W9" "Syntaxin-18 OS=Homo sapiens OX=9606 GN=STX18 PE=1 SV=1" "0.000" "False" "23.141" "11" "3" "4" "3" "335" "38.7" "5.49" "15.34" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10496" "53407" "ENSG00000168818" "STX18" "hsa:53407; Q596L3; Q5TZP5; Q9P2W9" "COPI-dependent Golgi-to-ER retrograde traffic" "" "1" "0" "0.991" "0.948" "0.970" "0.974" "0.925" "0.983" "1.010" "1.031" "0.922" "417.4" "413.6" "395.7" "404.9" "406.6" "386.3" "410.1" "421.4" "430.4" "384.8" "" "" "" "" "" "" "" "" "" "" "335.2" "298.5" "314.3" "271.3" "281.2" "289.8" "287.1" "307.7" "430.4" "312.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6896293366325971592" "False" "High" "IsMasterProtein" "Q8WWK9" "Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1" "0.000" "False" "23.127" "10" "8" "9" "8" "683" "76.9" "9.41" "27.74" "8" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "" "Pf15297" "26586" "ENSG00000136108" "CKAP2" "A2BDE0; A5YM58; B4DR35; E9PD90; hsa:26586; Q3KRA5; Q5VXB4; Q8IWV5; Q8IWV6; Q8WWK9; Q96FH9; Q9H012; Q9H0D0; Q9H988; Q9HC49; Q9NVG4" "" "" "0" "0" "1.022" "1.038" "1.120" "1.142" "1.093" "1.297" "1.344" "1.234" "1.158" "1044.6" "1067.5" "1084.2" "1170.0" "1192.7" "1141.9" "1354.8" "1404.3" "1289.4" "1210.0" "" "" "" "" "" "" "" "" "" "" "839.0" "770.3" "861.3" "783.9" "824.9" "856.7" "948.6" "1025.6" "1289.4" "984.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1711766393091945325" "False" "High" "IsMasterProtein" "Q6DKK2" "Tetratricopeptide repeat protein 19, mitochondrial OS=Homo sapiens OX=9606 GN=TTC19 PE=1 SV=4" "0.000" "False" "23.091" "15" "6" "6" "6" "380" "42.4" "5.77" "21.85" "6" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;cytoskeleton;mitochondrion;other cell component" "" "Pf13374, Pf13424" "54902" "ENSG00000011295" "TTC19" "A8MZ52; B3KP62; B4DN65; hsa:54902; Q2M248; Q6DKK2; Q7L3U8; Q9H6G3; Q9NXB2" "" "Mitochondrial complex III assembly" "1" "0" "0.949" "1.008" "1.008" "1.115" "1.054" "0.952" "0.969" "0.977" "1.021" "265.0" "251.4" "267.0" "267.2" "295.6" "279.4" "252.2" "256.7" "259.0" "270.6" "" "" "" "" "" "" "" "" "" "" "212.8" "181.4" "212.1" "179.0" "204.4" "209.6" "176.6" "187.4" "259.0" "220.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2304396321486536577" "False" "High" "IsMasterProtein" "Q8IXQ4" "GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1" "0.000" "False" "23.086" "13" "4" "5" "4" "340" "38.1" "5.41" "16.24" "4" "" "" "" "Pf12572" "55425" "ENSG00000133114" "GPALPP1" "A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6" "" "" "0" "0" "1.085" "1.092" "0.990" "0.970" "1.042" "0.927" "1.047" "0.982" "1.033" "434.5" "471.5" "474.3" "430.2" "421.5" "452.8" "402.7" "454.9" "426.5" "448.8" "" "" "" "" "" "" "" "" "" "" "349.0" "340.2" "376.8" "288.3" "291.5" "339.7" "282.0" "332.2" "426.5" "365.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-843135532772952093" "False" "High" "IsMasterProtein" "Q8TD55" "Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1" "0.000" "False" "23.085" "10" "5" "5" "5" "490" "53.3" "5.43" "15.48" "5" "other biological processes" "non-structural extracellular;other cell component" "" "Pf00169" "80301" "ENSG00000241839" "PLEKHO2" "hsa:80301; Q7L4H4; Q8TD55; Q8WYS8" "Neutrophil degranulation" "" "1" "0" "0.935" "0.978" "0.915" "0.925" "0.944" "0.970" "0.897" "1.108" "1.051" "338.6" "316.7" "331.3" "309.7" "313.2" "319.6" "328.5" "303.6" "375.2" "355.9" "" "" "" "" "" "" "" "" "" "" "271.9" "228.5" "263.1" "207.5" "216.6" "239.8" "230.0" "221.8" "375.2" "289.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1286800557191181783" "False" "High" "IsMasterProtein" "Q14686" "Nuclear receptor coactivator 6 OS=Homo sapiens OX=9606 GN=NCOA6 PE=1 SV=3" "0.000" "False" "23.033" "4" "6" "7" "6" "2063" "219.0" "9.36" "23.93" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13820" "23054" "ENSG00000198646" "NCOA6" "A6NLF1; B2RMN5; E1P5P7; hsa:23054; Q14686; Q9NTZ9; Q9UH74; Q9UK86" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Formation of WDR5-containing histone-modifying complexes; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Kleefstra syndrome" "15" "0" "0.986" "1.013" "1.070" "1.051" "1.017" "1.012" "1.104" "1.085" "1.041" "348.8" "344.0" "353.2" "373.4" "366.6" "354.9" "353.0" "385.1" "378.3" "363.2" "" "" "" "" "" "" "" "" "" "" "280.2" "248.2" "280.6" "250.1" "253.5" "266.2" "247.2" "281.2" "378.3" "295.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5324652532582305658" "False" "High" "IsMasterProtein" "P53779" "Mitogen-activated protein kinase 10 OS=Homo sapiens OX=9606 GN=MAPK10 PE=1 SV=2" "0.000" "False" "23.017" "15" "6" "7" "6" "464" "52.6" "6.79" "18.29" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5602" "ENSG00000109339" "MAPK10" "A6NFS3; A6NG28; B3KQ94; hsa:5602; P53779; Q15707; Q49AP1" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Focal adhesion; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Wnt signaling pathway and pluripotency; Oxidative stress response; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; G13 signaling pathway; 5q35 copy number variation; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "36" "0" "0.951" "0.938" "0.845" "1.041" "1.131" "0.877" "0.897" "0.927" "0.993" "151.2" "143.8" "141.8" "127.7" "157.4" "171.1" "132.7" "135.7" "140.2" "150.1" "" "" "" "" "" "" "" "" "" "" "121.5" "103.7" "112.6" "85.6" "108.8" "128.4" "92.9" "99.1" "140.2" "122.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441805136985848157" "False" "High" "IsMasterProtein" "Q8TB52" "F-box only protein 30 OS=Homo sapiens OX=9606 GN=FBXO30 PE=1 SV=3" "0.000" "False" "23.000" "7" "4" "7" "4" "745" "82.3" "5.40" "20.85" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf15965, Pf15966" "84085" "ENSG00000118496" "FBXO30" "hsa:84085; Q8TB52; Q9BXZ7" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.994" "0.946" "1.139" "1.149" "0.885" "1.014" "1.172" "0.943" "0.949" "106.4" "105.8" "100.7" "121.2" "122.3" "94.2" "108.0" "124.7" "100.4" "101.0" "" "" "" "" "" "" "" "" "" "" "85.5" "76.3" "80.0" "81.2" "84.6" "70.7" "75.6" "91.1" "100.4" "82.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3771039295331557619" "False" "High" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "0.000" "False" "22.975" "16" "6" "7" "6" "445" "50.4" "8.27" "21.57" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "Lipid metabolism pathway" "3" "0" "1.027" "0.896" "0.960" "1.103" "0.954" "1.022" "1.024" "1.007" "1.022" "191.9" "197.0" "171.9" "184.2" "211.6" "183.0" "196.0" "196.6" "193.3" "196.0" "" "" "" "" "" "" "" "" "" "" "154.1" "142.1" "136.5" "123.4" "146.3" "137.3" "137.2" "143.6" "193.3" "159.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3086265819139452668" "False" "High" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "0.000" "False" "22.955" "11" "4" "5" "4" "563" "61.2" "6.48" "19.02" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "XBP1(S) activates chaperone genes" "VEGFA-VEGFR2 signaling" "2" "0" "1.101" "1.004" "1.054" "1.073" "0.976" "1.009" "0.948" "0.925" "0.937" "81.6" "89.9" "82.0" "86.0" "87.5" "79.7" "82.3" "77.4" "75.5" "76.5" "" "" "" "" "" "" "" "" "" "" "65.6" "64.8" "65.1" "57.6" "60.5" "59.8" "57.7" "56.5" "75.5" "62.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486365272632798294" "False" "High" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "0.000" "False" "22.891" "53" "4" "11" "4" "75" "8.7" "5.45" "31.23" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Regulation of actin cytoskeleton" "8" "0" "1.096" "0.998" "0.995" "0.943" "1.085" "1.038" "1.059" "0.940" "1.032" "805.6" "883.1" "804.2" "801.8" "759.7" "873.9" "836.4" "853.2" "757.0" "831.7" "" "" "" "" "" "" "" "" "" "" "647.0" "637.2" "638.8" "537.2" "525.4" "655.7" "585.6" "623.1" "757.0" "676.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1812209145391096347" "False" "High" "IsMasterProtein" "P07919" "Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2" "0.000" "False" "22.827" "65" "4" "6" "4" "91" "10.7" "4.44" "24.11" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02320" "7388" "ENSG00000173660" "UQCRH" "B2R4V9; D3DQ18; hsa:7388; P07919; Q5TDF6; Q6LDB8; Q9BQ91" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "1.013" "0.986" "0.952" "0.960" "1.070" "1.034" "0.943" "1.040" "1.050" "643.2" "651.6" "634.0" "612.3" "617.6" "688.3" "665.2" "606.6" "669.1" "675.7" "" "" "" "" "" "" "" "" "" "" "516.6" "470.1" "503.6" "410.2" "427.2" "516.4" "465.7" "443.0" "669.1" "549.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4405181458594490981" "False" "High" "IsMasterProtein" "Q9NYL2" "Mitogen-activated protein kinase kinase kinase 20 OS=Homo sapiens OX=9606 GN=MAP3K20 PE=1 SV=3" "0.000" "False" "22.798" "6" "4" "5" "4" "800" "91.1" "7.87" "15.01" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00536, Pf07714" "51776" "ENSG00000091436" "MAP3K20" "B3KPG2; hsa:51776; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; Q9NYL2" "" "MAPK signaling pathway" "1" "0" "1.681" "1.105" "1.267" "1.185" "1.232" "1.024" "0.977" "1.146" "1.084" "343.9" "578.3" "380.1" "435.7" "407.4" "423.7" "352.2" "335.9" "394.2" "373.0" "" "" "" "" "" "" "" "" "" "" "276.3" "417.2" "302.0" "291.9" "281.8" "317.9" "246.6" "245.3" "394.2" "303.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985839782283071822" "False" "High" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "0.000" "False" "22.787" "8" "4" "5" "4" "480" "54.4" "6.61" "19.62" "4" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "Neutrophil degranulation; MHC class II antigen presentation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "Ciliary landscape" "6" "0" "0.995" "1.014" "0.885" "0.917" "1.090" "0.948" "0.997" "0.997" "0.949" "705.7" "702.0" "715.5" "624.7" "646.9" "769.0" "669.2" "703.5" "703.9" "669.5" "" "" "" "" "" "" "" "" "" "" "566.8" "506.6" "568.3" "418.5" "447.4" "577.0" "468.6" "513.7" "703.9" "544.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3161881869701219173" "False" "High" "IsMasterProtein" "O43715" "TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1" "0.000" "False" "22.720" "39" "4" "5" "4" "76" "8.8" "5.48" "17.56" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05254" "51499" "ENSG00000170855" "TRIAP1" "B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "5q35 copy number variation" "3" "0" "1.167" "1.042" "1.036" "0.980" "1.099" "0.989" "1.084" "1.025" "1.070" "632.9" "738.8" "659.5" "655.8" "620.4" "695.7" "625.9" "686.0" "648.6" "677.4" "" "" "" "" "" "" "" "" "" "" "508.4" "533.1" "523.9" "439.4" "429.1" "522.0" "438.2" "501.0" "648.6" "550.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1282007746480283530" "False" "High" "IsMasterProtein" "Q9BRJ7" "Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1" "0.000" "False" "22.660" "19" "4" "8" "4" "211" "23.3" "8.91" "30.71" "4" "other biological processes" "nucleus" "nucleic acid binding activity" "" "84309" "ENSG00000168101" "NUDT16L1" "Q8NAI2; Q9BRJ7" "" "" "0" "0" "0.947" "1.028" "0.892" "0.987" "1.036" "1.003" "0.945" "0.970" "0.886" "220.8" "209.2" "227.0" "197.0" "218.0" "228.8" "221.5" "208.7" "214.2" "195.6" "" "" "" "" "" "" "" "" "" "" "177.4" "151.0" "180.3" "132.0" "150.8" "171.6" "155.1" "152.4" "214.2" "159.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3119089922168410835" "False" "High" "IsMasterProtein" "P10606" "Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2" "0.000" "False" "22.656" "29" "4" "6" "4" "129" "13.7" "8.81" "17.78" "4" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01215" "1329" "ENSG00000135940; ENSG00000291596" "COX5B" "hsa:1329; P10606; Q53YB7; Q96J18; Q99610" "Mitochondrial protein degradation; Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "8" "0" "1.062" "0.981" "1.007" "1.098" "1.094" "1.009" "1.047" "1.006" "0.998" "407.3" "432.5" "399.6" "410.1" "447.1" "445.4" "410.9" "426.4" "409.6" "406.4" "" "" "" "" "" "" "" "" "" "" "327.1" "312.1" "317.4" "274.8" "309.2" "334.2" "287.7" "311.4" "409.6" "330.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477039985153313933" "False" "High" "IsMasterProtein" "O94952" "F-box only protein 21 OS=Homo sapiens OX=9606 GN=FBXO21 PE=1 SV=2" "0.000" "False" "22.646" "8" "5" "6" "5" "628" "72.2" "6.09" "22.35" "5" "protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf08755, Pf13369" "23014" "ENSG00000135108" "FBXO21" "B3KMF0; hsa:23014; O94952; Q5BJG0; Q9H087" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "0.985" "1.022" "1.141" "0.831" "1.034" "0.864" "0.856" "0.947" "0.991" "293.1" "288.7" "299.6" "334.4" "243.7" "303.2" "253.3" "250.9" "277.5" "290.4" "" "" "" "" "" "" "" "" "" "" "235.4" "208.3" "238.0" "224.0" "168.6" "227.5" "177.3" "183.2" "277.5" "236.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888778230352659976" "False" "High" "IsMasterProtein" "O14908" "PDZ domain-containing protein GIPC1 OS=Homo sapiens OX=9606 GN=GIPC1 PE=1 SV=2" "0.000" "False" "22.642" "17" "4" "4" "4" "333" "36.0" "6.28" "18.95" "4" "cell-cell signaling;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00595" "10755" "ENSG00000123159" "GIPC1" "A8K4I3; A8MZG3; hsa:10755; O14908; Q9BTC9" "FGFR1b ligand binding and activation; FGFR1c ligand binding and activation" "VEGFA-VEGFR2 signaling" "3" "0" "0.959" "0.972" "1.053" "1.115" "0.988" "0.948" "1.056" "0.984" "1.029" "227.0" "217.6" "220.6" "238.9" "253.0" "224.3" "215.2" "239.7" "223.4" "233.5" "" "" "" "" "" "" "" "" "" "" "182.3" "157.0" "175.3" "160.1" "175.0" "168.3" "150.7" "175.1" "223.4" "189.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1016656761563188351" "False" "High" "IsMasterProtein" "O15127" "Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2" "0.000" "False" "22.601" "16" "4" "5" "4" "329" "36.6" "6.10" "18.85" "4" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04144" "10066" "ENSG00000140497" "SCAMP2" "B2RDF0; hsa:10066; O15127; Q9BQE8" "" "Serotonin transporter activity; Monoamine transport" "2" "0" "0.924" "0.875" "1.016" "1.134" "1.197" "1.101" "1.211" "1.036" "1.010" "117.9" "108.9" "103.3" "119.8" "133.7" "141.2" "129.9" "142.9" "122.2" "119.1" "" "" "" "" "" "" "" "" "" "" "94.7" "78.6" "82.0" "80.3" "92.5" "105.9" "90.9" "104.3" "122.2" "96.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8009088926221679389" "False" "High" "IsMasterProtein" "P40616" "ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1" "0.000" "False" "22.552" "19" "4" "5" "4" "181" "20.4" "5.72" "16.56" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00025" "400" "ENSG00000120805" "ARL1" "B4DWW1; hsa:400; P40616; P80417; Q53XB1" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.284" "1.181" "1.354" "1.240" "1.291" "1.148" "1.081" "1.265" "1.166" "117.9" "151.3" "139.3" "159.6" "146.2" "152.2" "135.3" "127.4" "149.2" "137.4" "" "" "" "" "" "" "" "" "" "" "94.7" "109.2" "110.6" "106.9" "101.1" "114.2" "94.7" "93.0" "149.2" "111.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5145837311521029190" "False" "High" "IsMasterProtein" "Q8N183" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Homo sapiens OX=9606 GN=NDUFAF2 PE=1 SV=1" "0.000" "False" "22.544" "28" "4" "5" "4" "169" "19.8" "8.97" "17.03" "4" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf05071" "91942" "ENSG00000164182" "NDUFAF2" "A8K5I1; hsa:91942; Q8N183" "Complex I biogenesis" "SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "2" "0" "1.027" "0.949" "0.926" "0.936" "0.964" "0.983" "0.998" "1.019" "0.942" "542.2" "556.6" "514.8" "501.9" "507.3" "522.8" "533.0" "540.9" "552.3" "510.8" "" "" "" "" "" "" "" "" "" "" "435.5" "401.6" "408.9" "336.3" "350.9" "392.3" "373.2" "395.0" "552.3" "415.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9028171991778450679" "False" "High" "IsMasterProtein" "P27540" "Aryl hydrocarbon receptor nuclear translocator OS=Homo sapiens OX=9606 GN=ARNT PE=1 SV=1" "0.000" "False" "22.539" "6" "3" "4" "3" "789" "86.6" "6.54" "13.47" "3" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf14598" "405" "ENSG00000143437" "ARNT" "B2R9H1; C4AMA1; F8WAP6; hsa:405; P27540; Q59ED4; Q5QP39; Q8NDC7" "PPARA activates gene expression; NPAS4 regulates expression of target genes; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor" "Angiogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; 6q16 copy number variation" "16" "0" "1.126" "1.053" "1.124" "1.173" "1.046" "1.083" "1.055" "1.054" "1.035" "259.3" "291.9" "273.0" "291.4" "304.2" "271.3" "281.0" "273.6" "273.5" "268.5" "" "" "" "" "" "" "" "" "" "" "208.3" "210.6" "216.8" "195.2" "210.4" "203.6" "196.7" "199.8" "273.5" "218.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022881073250375863" "False" "High" "IsMasterProtein" "P16455" "Methylated-DNA--protein-cysteine methyltransferase OS=Homo sapiens OX=9606 GN=MGMT PE=1 SV=1" "0.000" "False" "22.527" "18" "3" "7" "3" "207" "21.6" "8.10" "21.69" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01035, Pf02870" "4255" "ENSG00000170430" "MGMT" "P16455; Q5VY78" "MGMT-mediated DNA damage reversal" "Direct reversal repair; DNA repair pathways, full network; p53 transcriptional gene network" "4" "0" "0.921" "1.047" "0.839" "0.952" "1.136" "0.960" "0.872" "0.833" "0.976" "78.5" "72.3" "82.2" "65.9" "74.8" "89.2" "75.4" "68.5" "65.4" "76.6" "" "" "" "" "" "" "" "" "" "" "63.1" "52.2" "65.3" "44.1" "51.7" "66.9" "52.8" "50.0" "65.4" "62.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3452513591771994158" "False" "High" "IsMasterProtein" "Q6ICG6" "Uncharacterized protein KIAA0930 OS=Homo sapiens OX=9606 GN=KIAA0930 PE=1 SV=1" "0.000" "False" "22.482" "20" "6" "6" "6" "404" "45.8" "7.94" "18.59" "6" "" "" "" "Pf09741" "23313" "ENSG00000100364" "KIAA0930" "B0QY17; B0QY19; B3KT48; hsa:23313; Q6ICG6; Q6ZVE5; Q7Z6K9; Q8IZ76; Q9Y2E2" "" "" "0" "0" "1.001" "0.949" "1.124" "1.055" "1.035" "1.056" "1.043" "1.032" "1.001" "375.0" "375.5" "356.0" "421.4" "395.6" "388.2" "396.1" "391.2" "387.0" "375.5" "" "" "" "" "" "" "" "" "" "" "301.2" "271.0" "282.8" "282.3" "273.6" "291.2" "277.4" "285.7" "387.0" "305.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3798154804985713391" "False" "High" "IsMasterProtein" "P41229" "Lysine-specific demethylase 5C OS=Homo sapiens OX=9606 GN=KDM5C PE=1 SV=2" "0.000" "False" "22.476" "4" "6" "7" "6" "1560" "175.6" "5.58" "23.59" "6" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf01388, Pf02373, Pf02375, Pf02928, Pf08429, Pf21323" "8242" "ENSG00000126012" "KDM5C" "B0QZ44; B4E3I2; F5H3T1; hsa:8242; P41229; Q5JUX3; Q5JUX4; Q5JUX5; Q7Z5S5" "HDMs demethylate histones" "Clear cell renal cell carcinoma pathways" "2" "0" "1.006" "0.953" "0.914" "0.990" "0.977" "0.862" "0.974" "0.917" "0.976" "582.9" "586.4" "555.3" "532.7" "577.2" "569.5" "502.5" "567.8" "534.7" "569.1" "" "" "" "" "" "" "" "" "" "" "468.2" "423.1" "441.1" "356.9" "399.2" "427.3" "351.8" "414.7" "534.7" "462.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588161142439279914" "False" "High" "IsMasterProtein" "Q96RG2" "PAS domain-containing serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=PASK PE=1 SV=3" "0.000" "False" "22.465" "3" "3" "3" "3" "1323" "142.8" "4.86" "13.65" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13426" "23178" "ENSG00000115687" "PASK" "G5E9F1; hsa:23178; Q05BE4; Q68DY3; Q6GSJ5; Q86XH6; Q96RG2; Q99763; Q9UFR7" "" "2q37 copy number variation syndrome" "1" "0" "1.138" "1.249" "1.609" "1.302" "1.302" "1.243" "1.091" "1.371" "1.345" "31.9" "36.3" "39.8" "51.3" "41.5" "41.5" "39.6" "34.8" "43.7" "42.9" "" "" "" "" "" "" "" "" "" "" "25.6" "26.2" "31.6" "34.4" "28.7" "31.2" "27.8" "25.4" "43.7" "34.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6296603921804072395" "False" "High" "IsMasterProtein" "Q9NSV4" "Protein diaphanous homolog 3 OS=Homo sapiens OX=9606 GN=DIAPH3 PE=1 SV=4" "0.000" "False" "22.433" "5" "8" "8" "8" "1193" "136.8" "7.03" "22.87" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "81624" "ENSG00000139734" "DIAPH3" "A2A3B8; A2A3B9; A2A3C0; hsa:81624; Q18P99; Q18PA0; Q18PA1; Q2KPB6; Q3ZK23; Q5JTP8; Q5T2S7; Q5XKF6; Q6MZF0; Q6NUP0; Q86VS4; Q8NAV4; Q9NSV4" "RHO GTPases Activate Formins; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "Regulation of actin cytoskeleton" "14" "0" "1.054" "0.993" "1.062" "1.072" "1.022" "1.009" "1.176" "1.184" "1.037" "506.0" "533.4" "502.5" "537.5" "542.2" "517.1" "510.6" "595.0" "599.2" "524.5" "" "" "" "" "" "" "" "" "" "" "406.4" "384.9" "399.2" "360.1" "375.0" "388.0" "357.5" "434.5" "599.2" "426.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "342990274906048664" "False" "High" "IsMasterProtein" "P48730" "Casein kinase I isoform delta OS=Homo sapiens OX=9606 GN=CSNK1D PE=1 SV=2" "0.000" "False" "22.428" "14" "5" "7" "2" "415" "47.3" "9.74" "21.90" "5" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1453" "ENSG00000141551" "CSNK1D" "A2I2P2; hsa:1453; P48730; Q96KZ6; Q9BTN5" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Major pathway of rRNA processing in the nucleolus and cytosol; Circadian Clock; COPII-mediated vesicle transport" "Melatonin metabolism and effects; Wnt signaling pathway; Hedgehog signaling pathway" "13" "2" "0.977" "1.014" "1.009" "1.014" "1.008" "1.036" "1.043" "0.922" "0.985" "391.8" "382.6" "397.4" "395.2" "397.4" "394.9" "406.0" "408.6" "361.2" "385.9" "" "" "" "" "" "" "" "" "" "" "314.7" "276.1" "315.7" "264.8" "274.9" "296.3" "284.3" "298.4" "361.2" "313.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1756895692335459560" "False" "High" "IsMasterProtein" "O95865" "Putative hydrolase DDAH2 OS=Homo sapiens OX=9606 GN=DDAH2 PE=1 SV=1" "0.000" "False" "22.422" "19" "4" "4" "4" "285" "29.6" "6.01" "14.93" "4" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "" "23564" "ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076" "DDAH2" "A2BEZ7; hsa:23564; O95865" "" "Nitric oxide metabolism in cystic fibrosis" "1" "0" "1.005" "0.953" "1.055" "0.991" "0.985" "0.913" "0.957" "1.072" "1.000" "195.3" "196.4" "186.1" "206.0" "193.5" "192.5" "178.3" "186.8" "209.3" "195.3" "" "" "" "" "" "" "" "" "" "" "156.9" "141.7" "147.8" "138.0" "133.8" "144.4" "124.8" "136.4" "209.3" "158.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-375580382225270930" "False" "High" "IsMasterProtein" "Q96LI5" "CCR4-NOT transcription complex subunit 6-like OS=Homo sapiens OX=9606 GN=CNOT6L PE=1 SV=2" "0.000" "False" "22.421" "7" "3" "5" "3" "555" "63.0" "6.74" "15.06" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03372, Pf13855" "246175" "ENSG00000138767" "CNOT6L" "hsa:246175; Q96LI5; Q9UF92" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "Ciliary landscape" "4" "0" "0.997" "0.975" "1.050" "1.064" "1.067" "1.046" "1.106" "1.060" "1.145" "450.4" "449.1" "439.2" "472.8" "479.2" "480.4" "470.9" "498.1" "477.4" "515.7" "" "" "" "" "" "" "" "" "" "" "361.7" "324.0" "348.8" "316.7" "331.4" "360.4" "329.7" "363.8" "477.4" "419.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036533815918111608" "False" "High" "IsMasterProtein" "Q9NP72" "Ras-related protein Rab-18 OS=Homo sapiens OX=9606 GN=RAB18 PE=1 SV=1" "0.000" "False" "22.364" "28" "5" "5" "5" "206" "23.0" "5.24" "14.89" "5" "cell organization and biogenesis;transport;developmental processes;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "22931" "ENSG00000099246" "RAB18" "B3KMC7; B7Z333; D3DRW1; hsa:22931; Q53FX8; Q56UN9; Q6FIH1; Q9NP72" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "" "4" "0" "0.900" "0.963" "0.894" "0.879" "0.952" "0.886" "0.872" "0.926" "0.977" "601.4" "541.3" "579.4" "537.4" "528.4" "572.8" "533.0" "524.7" "557.0" "587.6" "" "" "" "" "" "" "" "" "" "" "483.0" "390.6" "460.2" "360.0" "365.5" "429.8" "373.2" "383.2" "557.0" "477.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607454407969117171" "False" "High" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "0.000" "False" "22.364" "17" "4" "4" "4" "376" "40.1" "5.27" "17.38" "4" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "Protein hydroxylation" "" "1" "0" "1.032" "1.048" "1.138" "1.126" "1.007" "1.088" "0.960" "0.983" "1.005" "365.7" "377.4" "383.4" "416.2" "411.7" "368.3" "398.0" "351.2" "359.4" "367.5" "" "" "" "" "" "" "" "" "" "" "293.7" "272.3" "304.6" "278.9" "284.7" "276.4" "278.7" "256.5" "359.4" "298.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-567970208974842497" "False" "High" "IsMasterProtein" "P51530" "DNA replication ATP-dependent helicase/nuclease DNA2 OS=Homo sapiens OX=9606 GN=DNA2 PE=1 SV=3" "0.000" "False" "22.355" "7" "8" "10" "6" "1060" "120.3" "7.74" "27.07" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08696, Pf12705, Pf13086, Pf13087, Pf21123" "1763" "ENSG00000138346" "DNA2" "hsa:1763; P51530; Q2NKM1; Q5TC49; Q5TC50; Q6P455; Q6PI80; Q7Z6H9; Q8N346" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "" "16" "0" "1.538" "0.821" "1.296" "1.149" "0.727" "1.379" "1.142" "1.041" "0.955" "28.6" "43.9" "23.5" "37.0" "32.8" "20.8" "39.4" "32.6" "29.7" "27.3" "" "" "" "" "" "" "" "" "" "" "22.9" "31.7" "18.6" "24.8" "22.7" "15.6" "27.6" "23.8" "29.7" "22.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657870357206849576" "False" "High" "IsMasterProtein" "Q9Y2Y0" "ADP-ribosylation factor-like protein 2-binding protein OS=Homo sapiens OX=9606 GN=ARL2BP PE=1 SV=1" "0.000" "False" "22.348" "22" "3" "4" "3" "163" "18.8" "4.35" "11.33" "3" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11527" "23568" "ENSG00000102931" "ARL2BP" "B3KQJ5; hsa:23568; Q504R0; Q9Y2Y0" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" "Ciliopathies" "2" "0" "0.863" "0.845" "0.841" "0.803" "0.930" "0.874" "0.882" "0.814" "0.906" "260.5" "224.9" "220.0" "219.1" "209.2" "242.3" "227.8" "229.7" "212.0" "236.0" "" "" "" "" "" "" "" "" "" "" "209.2" "162.3" "174.8" "146.8" "144.7" "181.8" "159.5" "167.7" "212.0" "191.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8852376921802983428" "False" "High" "IsMasterProtein" "Q9UN19" "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide OS=Homo sapiens OX=9606 GN=DAPP1 PE=1 SV=1" "0.000" "False" "22.334" "24" "5" "7" "5" "280" "32.2" "7.80" "15.72" "5" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00017, Pf00169" "27071" "ENSG00000070190" "DAPP1" "hsa:27071; Q8TCK5; Q9UHF2; Q9UN19" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway" "2" "0" "1.006" "1.205" "1.048" "1.121" "1.092" "1.142" "1.289" "1.227" "1.114" "311.5" "313.3" "375.5" "326.4" "349.3" "340.2" "355.8" "401.6" "382.2" "347.2" "" "" "" "" "" "" "" "" "" "" "250.2" "226.1" "298.3" "218.7" "241.6" "255.3" "249.1" "293.3" "382.2" "282.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7819708601940239359" "False" "High" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "0.000" "False" "22.333" "12" "4" "5" "4" "323" "37.6" "7.15" "17.57" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "39" "0" "1.009" "0.929" "0.994" "0.977" "0.958" "0.958" "0.893" "0.952" "0.980" "363.9" "367.0" "338.0" "361.9" "355.7" "348.7" "348.6" "325.1" "346.6" "356.5" "" "" "" "" "" "" "" "" "" "" "292.3" "264.8" "268.5" "242.5" "246.0" "261.6" "244.1" "237.4" "346.6" "289.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3553931004733427798" "False" "High" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "0.000" "False" "22.328" "24" "3" "18" "3" "86" "9.7" "4.67" "46.39" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "snRNP Assembly; mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.062" "1.062" "1.123" "1.091" "1.054" "1.055" "1.094" "1.012" "1.060" "609.6" "647.4" "647.6" "684.3" "664.9" "642.3" "643.1" "667.0" "617.1" "645.9" "" "" "" "" "" "" "" "" "" "" "489.6" "467.1" "514.4" "458.5" "459.8" "481.9" "450.3" "487.1" "617.1" "525.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8377264718886898276" "False" "High" "IsMasterProtein" "Q9Y2K7" "Lysine-specific demethylase 2A OS=Homo sapiens OX=9606 GN=KDM2A PE=1 SV=3" "0.000" "False" "22.308" "3" "3" "5" "3" "1162" "132.7" "7.58" "18.87" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00646, Pf02008, Pf16866, Pf17811" "22992" "ENSG00000173120" "KDM2A" "D4QA03; E9PIL6; hsa:22992; I3VM55; Q49A21; Q4G0M3; Q69YY8; Q9BVH5; Q9H7H5; Q9UK66; Q9Y2K7" "HDMs demethylate histones" "" "1" "0" "1.011" "1.001" "1.051" "1.149" "1.108" "1.251" "1.081" "1.053" "1.109" "371.1" "375.1" "371.5" "390.1" "426.5" "411.1" "464.2" "401.0" "390.6" "411.4" "" "" "" "" "" "" "" "" "" "" "298.1" "270.6" "295.1" "261.4" "295.0" "308.5" "325.0" "292.8" "390.6" "334.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8367261200096812552" "False" "High" "IsMasterProtein" "O15091" "Mitochondrial ribonuclease P catalytic subunit OS=Homo sapiens OX=9606 GN=PRORP PE=1 SV=2" "0.000" "False" "22.295" "10" "5" "5" "5" "583" "67.3" "8.78" "19.28" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf16953" "9692" "ENSG00000100890" "PRORP" "B4DXD9; B4E0S8; B4E211; C4AM93; D3DS99; D3DSA1; hsa:9692; O15091; Q86SZ4; Q86YB5; Q8N5L5" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "" "3" "0" "1.040" "1.031" "1.034" "0.995" "1.020" "1.005" "1.076" "1.041" "1.028" "628.7" "653.8" "648.2" "650.1" "625.7" "641.3" "631.5" "676.7" "654.6" "646.0" "" "" "" "" "" "" "" "" "" "" "505.0" "471.7" "514.9" "435.6" "432.8" "481.1" "442.2" "494.2" "654.6" "525.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964659957025433859" "False" "High" "IsMasterProtein" "Q9H2H8" "Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1" "0.000" "False" "22.294" "35" "5" "10" "5" "161" "18.1" "6.79" "29.29" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160" "53938" "ENSG00000240344" "PPIL3" "hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8" "mRNA Splicing - Major Pathway" "" "1" "0" "0.921" "0.947" "0.987" "0.910" "0.970" "0.938" "0.897" "0.928" "0.966" "1004.4" "924.8" "951.2" "991.7" "914.4" "974.2" "941.9" "900.9" "932.1" "970.2" "" "" "" "" "" "" "" "" "" "" "806.7" "667.3" "755.6" "664.4" "632.4" "730.9" "659.5" "657.9" "932.1" "789.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1234088544826657040" "False" "High" "IsMasterProtein" "Q9H871" "E3 ubiquitin-protein transferase RMND5A OS=Homo sapiens OX=9606 GN=RMND5A PE=1 SV=1" "0.000" "False" "22.289" "11" "4" "5" "4" "391" "44.0" "6.06" "15.87" "4" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10607, Pf13445" "64795" "ENSG00000153561" "RMND5A" "D6W5M6; hsa:64795; Q6NTF0; Q9H6W5; Q9H871; Q9H9H2" "" "Ciliary landscape" "1" "0" "1.112" "1.116" "0.998" "0.969" "1.043" "0.971" "0.938" "1.065" "1.090" "122.5" "136.3" "136.8" "122.3" "118.7" "127.8" "119.0" "114.9" "130.5" "133.6" "" "" "" "" "" "" "" "" "" "" "98.4" "98.3" "108.6" "81.9" "82.1" "95.9" "83.3" "83.9" "130.5" "108.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8214160649428381093" "False" "High" "IsMasterProtein" "P22415" "Upstream stimulatory factor 1 OS=Homo sapiens OX=9606 GN=USF1 PE=1 SV=1" "0.000" "False" "22.282" "14" "4" "6" "3" "310" "33.5" "5.54" "19.49" "4" "stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7391" "ENSG00000158773" "USF1" "B2RBZ4; hsa:7391; P22415; Q5SY46; Q7Z5Y1" "Estrogen-dependent gene expression" "7q11.23 copy number variation syndrome; Familial hyperlipidemia type 2" "3" "0" "1.020" "0.979" "0.984" "0.927" "0.973" "0.938" "0.897" "0.939" "0.914" "325.4" "331.8" "318.4" "320.4" "301.6" "316.5" "305.1" "291.7" "305.6" "297.3" "" "" "" "" "" "" "" "" "" "" "261.4" "239.4" "252.9" "214.6" "208.6" "237.5" "213.6" "213.1" "305.6" "241.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "584714024089658403" "False" "High" "IsMasterProtein" "Q5XPI4" "E3 ubiquitin-protein ligase RNF123 OS=Homo sapiens OX=9606 GN=RNF123 PE=1 SV=1" "0.000" "False" "22.279" "4" "6" "7" "5" "1314" "148.4" "6.74" "20.16" "6" "protein metabolism;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf13920" "63891" "ENSG00000164068" "RNF123" "A1L4Q3; A6NLS5; hsa:63891; Q5I022; Q5XPI4; Q6PFW4; Q71RH0; Q8IW18; Q9H0M8; Q9H5L8; Q9H9T2" "Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "1.019" "1.000" "1.028" "0.974" "1.002" "0.959" "0.983" "0.963" "0.995" "563.2" "574.0" "563.2" "578.8" "548.7" "564.1" "540.3" "553.9" "542.3" "560.4" "" "" "" "" "" "" "" "" "" "" "452.4" "414.2" "447.4" "387.8" "379.5" "423.3" "378.3" "404.5" "542.3" "455.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491250249564736583" "False" "High" "IsMasterProtein" "P49902" "Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1" "0.000" "False" "22.276" "11" "6" "9" "6" "561" "64.9" "6.14" "31.31" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf05761" "22978" "ENSG00000076685" "NT5C2" "B7Z382; D3DR91; hsa:22978; P49902; Q5JUV5" "Purine catabolism; Ribavirin ADME; Abacavir metabolism" "" "3" "0" "0.958" "1.047" "0.942" "0.969" "1.013" "0.946" "0.975" "0.987" "0.993" "891.2" "854.0" "932.9" "840.0" "863.5" "902.5" "842.7" "869.1" "879.4" "884.6" "" "" "" "" "" "" "" "" "" "" "715.8" "616.2" "741.0" "562.8" "597.2" "677.2" "590.0" "634.7" "879.4" "719.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3372054881013806202" "False" "High" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "0.000" "False" "22.269" "18" "3" "5" "3" "263" "28.3" "8.38" "17.09" "3" "transport" "other membranes" "" "Pf07933" "55707" "ENSG00000157191; ENSG00000291380" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "0.888" "0.996" "0.897" "1.107" "0.782" "0.961" "1.000" "0.977" "0.989" "80.6" "71.5" "80.3" "72.3" "89.2" "63.0" "77.4" "80.6" "78.7" "79.7" "" "" "" "" "" "" "" "" "" "" "64.7" "51.6" "63.8" "48.4" "61.7" "47.3" "54.2" "58.9" "78.7" "64.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3294406842495901290" "False" "High" "IsMasterProtein" "Q8NHM5" "Lysine-specific demethylase 2B OS=Homo sapiens OX=9606 GN=KDM2B PE=1 SV=1" "0.000" "False" "22.253" "5" "7" "7" "7" "1336" "152.5" "8.56" "17.74" "7" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02008, Pf12937, Pf13621, Pf16866, Pf17811" "84678" "ENSG00000089094" "KDM2B" "A8MRS1; hsa:84678; Q1RLM7; Q8NCI2; Q8NHM5; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75" "HDMs demethylate histones" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "2" "0" "1.046" "1.004" "1.027" "1.049" "1.036" "0.972" "0.987" "1.103" "1.047" "371.4" "388.5" "373.1" "381.3" "389.6" "384.8" "361.1" "366.7" "409.7" "388.8" "" "" "" "" "" "" "" "" "" "" "298.3" "280.4" "296.4" "255.5" "269.5" "288.7" "252.8" "267.8" "409.7" "316.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227008394942671266" "False" "High" "IsMasterProtein" "Q9BUQ8" "Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3" "0.000" "False" "22.248" "6" "5" "8" "5" "820" "95.5" "9.55" "23.43" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "9416" "ENSG00000174243" "DDX23" "B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "0.966" "1.299" "1.119" "0.990" "1.017" "1.066" "1.273" "1.022" "1.072" "121.3" "117.2" "157.6" "135.7" "120.1" "123.4" "129.3" "154.5" "124.0" "130.1" "" "" "" "" "" "" "" "" "" "" "97.4" "84.6" "125.2" "90.9" "83.1" "92.6" "90.6" "112.8" "124.0" "105.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2891424664368030590" "False" "High" "IsMasterProtein" "Q8N6T3" "ADP-ribosylation factor GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARFGAP1 PE=1 SV=2" "0.000" "False" "22.245" "13" "4" "5" "4" "406" "44.6" "5.66" "14.01" "4" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "55738" "ENSG00000101199" "ARFGAP1" "B7Z3U0; B7Z8H8; B7ZBI3; E1P5I9; E7EV62; hsa:55738; Q6PK71; Q8N6T3; Q96KC4; Q96T02; Q9NSU3; Q9NVF6; Q9UIL0" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Clathrin-mediated endocytosis; XBP1(S) activates chaperone genes" "IL-18 signaling pathway" "5" "0" "1.040" "1.039" "1.170" "0.992" "1.059" "0.941" "1.171" "1.140" "0.971" "107.2" "111.4" "111.3" "125.4" "106.3" "113.6" "100.9" "125.5" "122.2" "104.1" "" "" "" "" "" "" "" "" "" "" "86.1" "80.4" "88.4" "84.0" "73.5" "85.2" "70.7" "91.7" "122.2" "84.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387602003086690885" "False" "High" "IsMasterProtein" "Q9BVC5" "Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1" "0.000" "False" "22.207" "25" "5" "5" "5" "232" "25.8" "9.74" "18.76" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf15323" "79074" "ENSG00000135974" "C2orf49" "B3KXN3; B4E2G9; hsa:79074; Q9BVC5" "tRNA processing in the nucleus" "" "1" "0" "1.010" "0.991" "0.989" "0.930" "0.928" "0.911" "0.885" "0.922" "0.957" "677.5" "684.3" "671.3" "670.2" "630.2" "628.4" "617.0" "599.6" "624.4" "648.0" "" "" "" "" "" "" "" "" "" "" "544.1" "493.8" "533.2" "449.0" "435.9" "471.5" "432.0" "437.9" "624.4" "527.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172063933685251467" "False" "High" "IsMasterProtein" "Q9BTA9" "WW domain-containing adapter protein with coiled-coil OS=Homo sapiens OX=9606 GN=WAC PE=1 SV=3" "0.000" "False" "22.200" "8" "5" "5" "5" "647" "70.7" "9.45" "15.97" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00397" "51322" "ENSG00000095787" "WAC" "A8K2A9; C9JBT9; D3DRW5; D3DRW6; D3DRW7; hsa:51322; Q53EN9; Q5JU75; Q5JU77; Q5VXK0; Q5VXK2; Q8TCK1; Q96DP3; Q96FW6; Q96JI3; Q9BTA9" "E3 ubiquitin ligases ubiquitinate target proteins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4321447803487511562" "False" "High" "IsMasterProtein" "Q8NEZ2" "Vacuolar protein sorting-associated protein 37A OS=Homo sapiens OX=9606 GN=VPS37A PE=1 SV=1" "0.000" "False" "22.130" "15" "4" "5" "4" "397" "44.3" "5.57" "21.36" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf07200" "137492" "ENSG00000155975" "VPS37A" "hsa:137492; Q336D5; Q6NW27; Q8N3D7; Q8NEZ2; Q8TBL7; Q96DL9" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "7q11.23 copy number variation syndrome" "6" "0" "0.888" "1.012" "0.987" "1.025" "0.997" "0.966" "1.006" "1.163" "1.058" "150.4" "133.6" "152.3" "148.4" "154.2" "150.0" "145.2" "151.4" "174.9" "159.2" "" "" "" "" "" "" "" "" "" "" "120.8" "96.4" "121.0" "99.4" "106.6" "112.5" "101.7" "110.5" "174.9" "129.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822360151641721881" "False" "High" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "0.000" "False" "22.115" "12" "5" "5" "5" "518" "58.2" "8.13" "18.46" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Mitochondrial tRNA aminoacylation" "Selenium metabolism and selenoproteins" "2" "0" "1.067" "1.009" "1.158" "1.074" "1.021" "1.122" "1.097" "1.074" "1.109" "268.8" "286.7" "271.2" "311.2" "288.6" "274.3" "301.6" "294.9" "288.7" "298.2" "" "" "" "" "" "" "" "" "" "" "215.9" "206.9" "215.4" "208.5" "199.6" "205.8" "211.2" "215.4" "288.7" "242.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643109724268830478" "False" "High" "IsMasterProtein" "Q8WUH1" "Protein Churchill OS=Homo sapiens OX=9606 GN=CHURC1 PE=1 SV=3" "0.000" "False" "22.092" "25" "2" "5" "2" "112" "12.9" "4.84" "16.27" "2" "signal transduction;other biological processes" "" "other molecular function" "Pf06573" "91612" "ENSG00000258289" "CHURC1" "A0A0C4DGJ7; B3KQ81; G3V1X3; G3V214; hsa:91612; Q8WUH1; Q9H3K7" "" "" "0" "0" "0.962" "0.891" "0.891" "0.899" "1.015" "0.902" "1.008" "1.015" "0.878" "450.1" "432.9" "401.1" "401.1" "404.5" "456.9" "406.2" "453.6" "456.9" "395.3" "" "" "" "" "" "" "" "" "" "" "361.5" "312.4" "318.6" "268.7" "279.8" "342.8" "284.4" "331.2" "456.9" "321.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7874915043186486884" "False" "High" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "0.000" "False" "22.064" "23" "3" "7" "3" "102" "11.5" "4.16" "15.01" "3" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "" "IL-18 signaling pathway" "1" "0" "1.076" "1.011" "1.012" "0.938" "1.001" "0.865" "0.969" "0.940" "0.921" "879.4" "946.0" "889.1" "889.6" "824.8" "880.2" "761.1" "852.2" "826.8" "810.1" "" "" "" "" "" "" "" "" "" "" "706.4" "682.6" "706.3" "596.0" "570.5" "660.4" "532.9" "622.4" "826.8" "658.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1360420814074918380" "False" "High" "IsMasterProtein" "Q5T653" "Large ribosomal subunit protein uL2m OS=Homo sapiens OX=9606 GN=MRPL2 PE=1 SV=2" "0.000" "False" "22.046" "16" "4" "4" "4" "305" "33.3" "11.30" "16.14" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00181, Pf03947" "51069" "ENSG00000112651" "MRPL2" "B2RC56; hsa:51069; Q5T653; Q8WUL1; Q96Q56; Q9Y311" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.063" "0.977" "0.992" "1.075" "1.072" "0.957" "0.942" "1.028" "0.984" "400.8" "426.2" "391.7" "397.4" "430.9" "429.6" "383.4" "377.4" "412.1" "394.4" "" "" "" "" "" "" "" "" "" "" "321.9" "307.5" "311.1" "266.3" "298.0" "322.3" "268.5" "275.6" "412.1" "320.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564377166653415060" "False" "High" "IsMasterProtein" "Q5JS54" "Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2" "0.000" "False" "22.032" "35" "3" "5" "3" "123" "13.8" "6.52" "13.27" "3" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf16093" "389362" "ENSG00000180822" "PSMG4" "C9J2F8; F8WBZ2; hsa:389362; Q5JS53; Q5JS54; Q5JS56" "" "" "0" "0" "0.935" "0.844" "0.923" "0.918" "0.865" "0.787" "0.848" "0.833" "0.895" "342.0" "319.7" "288.5" "315.6" "313.9" "296.0" "269.3" "290.1" "284.9" "306.0" "" "" "" "" "" "" "" "" "" "" "274.7" "230.7" "229.2" "211.4" "217.1" "222.1" "188.6" "211.9" "284.9" "248.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699838257049576232" "False" "High" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "0.000" "False" "22.009" "7" "7" "8" "7" "876" "98.4" "9.32" "19.20" "7" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "0" "1.048" "0.958" "1.010" "1.053" "0.954" "1.072" "1.049" "1.101" "0.978" "486.1" "509.3" "465.8" "491.2" "512.0" "463.9" "521.0" "509.7" "535.2" "475.4" "" "" "" "" "" "" "" "" "" "" "390.4" "367.5" "370.0" "329.1" "354.1" "348.1" "364.8" "372.2" "535.2" "386.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966117974293097362" "False" "High" "IsMasterProtein" "Q9UHL4" "Dipeptidyl peptidase 2 OS=Homo sapiens OX=9606 GN=DPP7 PE=1 SV=3" "0.000" "False" "21.977" "13" "6" "9" "6" "492" "54.3" "6.32" "25.52" "6" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "29952" "ENSG00000176978" "DPP7" "A8K7U7; hsa:29952; Q5VSF1; Q969X4; Q9UHL4" "Neutrophil degranulation" "" "1" "0" "0.962" "0.931" "0.925" "1.098" "1.048" "0.969" "0.967" "1.030" "1.064" "179.9" "173.1" "167.5" "166.4" "197.5" "188.6" "174.3" "173.9" "185.4" "191.5" "" "" "" "" "" "" "" "" "" "" "144.5" "124.9" "133.0" "111.5" "136.6" "141.5" "122.0" "127.0" "185.4" "155.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8795922102085507366" "False" "High" "IsMasterProtein" "Q9ULM3" "YEATS domain-containing protein 2 OS=Homo sapiens OX=9606 GN=YEATS2 PE=1 SV=2" "0.000" "False" "21.975" "4" "6" "6" "5" "1422" "150.7" "8.98" "18.39" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03366" "55689" "ENSG00000163872" "YEATS2" "A7E2B9; D3DNS9; hsa:55689; Q641P6; Q9NW96; Q9ULM3" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "1.228" "1.118" "1.086" "1.388" "1.294" "1.082" "0.970" "1.180" "1.342" "18.0" "22.1" "20.1" "19.5" "25.0" "23.3" "19.5" "17.4" "21.2" "24.1" "" "" "" "" "" "" "" "" "" "" "14.5" "15.9" "16.0" "13.1" "17.3" "17.5" "13.6" "12.7" "21.2" "19.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "309622094588707554" "False" "High" "IsMasterProtein" "Q9UHK0" "FMR1-interacting protein NUFIP1 OS=Homo sapiens OX=9606 GN=NUFIP1 PE=1 SV=2" "0.000" "False" "21.951" "12" "5" "5" "5" "495" "56.3" "9.13" "19.23" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10453" "26747" "ENSG00000083635" "NUFIP1" "hsa:26747; Q8WVM5; Q96SG1; Q9UHK0" "" "" "0" "0" "0.939" "1.047" "1.052" "1.027" "1.006" "1.079" "1.096" "0.981" "0.990" "375.2" "352.2" "392.7" "394.6" "385.3" "377.6" "404.8" "411.2" "368.1" "371.4" "" "" "" "" "" "" "" "" "" "" "301.4" "254.1" "312.0" "264.4" "266.5" "283.3" "283.4" "300.3" "368.1" "302.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825408205880823904" "False" "High" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "0.000" "False" "21.951" "15" "6" "6" "6" "433" "48.3" "7.47" "20.89" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Nuclear events stimulated by ALK signaling in cancer; Phosphorylation of Emi1" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; IL-19 signaling pathway; DNA damage response" "33" "0" "1.021" "0.959" "0.992" "0.985" "0.926" "0.875" "0.971" "0.965" "0.939" "900.5" "919.4" "863.2" "893.2" "886.7" "834.0" "787.9" "874.3" "869.0" "845.8" "" "" "" "" "" "" "" "" "" "" "723.3" "663.4" "685.6" "598.4" "613.3" "625.7" "551.6" "638.5" "869.0" "687.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2608297445267441955" "False" "High" "IsMasterProtein" "Q96QR8" "Transcriptional regulator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "0.000" "False" "21.949" "15" "5" "7" "5" "312" "33.2" "5.43" "20.84" "5" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "0" "0.967" "1.015" "1.019" "0.968" "1.034" "0.982" "0.976" "0.967" "1.014" "985.7" "953.6" "1000.0" "1004.4" "954.4" "1018.9" "967.8" "962.1" "953.1" "999.3" "" "" "" "" "" "" "" "" "" "" "791.7" "688.1" "794.4" "672.9" "660.1" "764.5" "677.6" "702.6" "953.1" "812.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5802259196988862678" "False" "High" "IsMasterProtein" "Q9NUY8" "TBC1 domain family member 23 OS=Homo sapiens OX=9606 GN=TBC1D23 PE=1 SV=3" "0.000" "False" "21.932" "4" "2" "3" "2" "699" "78.3" "5.41" "14.59" "2" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cell component" "" "Pf00566, Pf00581, Pf19430" "55773" "ENSG00000036054" "TBC1D23" "B9A6M5; hsa:55773; Q8TCN8; Q8WUB7; Q96D90; Q9NUY8; Q9NV75" "" "" "0" "0" "0.966" "0.984" "1.052" "1.009" "1.020" "0.986" "0.953" "1.008" "0.922" "150.0" "145.0" "147.5" "157.9" "151.3" "153.0" "147.9" "143.0" "151.2" "138.3" "" "" "" "" "" "" "" "" "" "" "120.5" "104.6" "117.2" "105.8" "104.7" "114.8" "103.5" "104.4" "151.2" "112.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4393204020125526762" "False" "High" "IsMasterProtein" "O75164" "Lysine-specific demethylase 4A OS=Homo sapiens OX=9606 GN=KDM4A PE=1 SV=2" "0.000" "False" "21.926" "5" "5" "5" "5" "1064" "120.6" "5.85" "14.99" "5" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "9682" "ENSG00000066135" "KDM4A" "hsa:9682; O75164; Q5VVB1" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "" "3" "0" "1.099" "1.008" "1.098" "1.031" "1.084" "0.916" "1.066" "0.963" "1.025" "225.3" "247.6" "227.1" "247.4" "232.3" "244.2" "206.4" "240.3" "217.0" "231.0" "" "" "" "" "" "" "" "" "" "" "181.0" "178.7" "180.4" "165.8" "160.7" "183.2" "144.5" "175.5" "217.0" "187.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1655251497259487415" "False" "High" "IsMasterProtein" "Q9BV38" "WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2" "0.000" "False" "21.908" "9" "4" "5" "4" "432" "47.4" "6.70" "17.04" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf14077" "57418" "ENSG00000065268" "WDR18" "hsa:57418; O60390; Q9BV38; Q9BWR2" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.985" "1.014" "1.028" "1.061" "1.044" "1.073" "1.028" "1.018" "0.981" "411.6" "405.5" "417.6" "423.1" "436.8" "429.7" "441.9" "423.2" "419.0" "403.8" "" "" "" "" "" "" "" "" "" "" "330.6" "292.6" "331.7" "283.5" "302.1" "322.4" "309.4" "309.1" "419.0" "328.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6046703873344704710" "False" "High" "IsMasterProtein" "Q9H1D9" "DNA-directed RNA polymerase III subunit RPC6 OS=Homo sapiens OX=9606 GN=POLR3F PE=1 SV=1" "0.000" "False" "21.906" "13" "4" "6" "4" "316" "35.7" "6.11" "17.84" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05158" "10621" "ENSG00000132664" "POLR3F" "A8K4C7; hsa:10621; O15319; Q9H1D9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "10" "0" "0.940" "0.833" "0.979" "0.942" "0.817" "0.950" "0.942" "0.856" "0.981" "288.8" "271.4" "240.6" "282.8" "272.1" "235.8" "274.3" "271.9" "247.3" "283.4" "" "" "" "" "" "" "" "" "" "" "231.9" "195.9" "191.1" "189.4" "188.2" "176.9" "192.1" "198.6" "247.3" "230.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413974576400389324" "False" "High" "IsMasterProtein" "Q9NQT5" "Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3" "0.000" "False" "21.898" "22" "5" "7" "5" "275" "29.6" "8.10" "21.82" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf15985, Pf21261, Pf21262" "51010" "ENSG00000107371" "EXOSC3" "A8K0K6; hsa:51010; Q5QP85; Q9NQT5; Q9Y3A8" "ATF4 activates genes in response to endoplasmic reticulum stress; mRNA decay by 3' to 5' exoribonuclease; Major pathway of rRNA processing in the nucleolus and cytosol; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "" "6" "0" "1.054" "1.065" "1.085" "1.030" "1.028" "1.063" "1.044" "1.022" "1.005" "632.9" "667.2" "674.2" "686.7" "652.0" "650.4" "672.9" "660.9" "647.1" "636.4" "" "" "" "" "" "" "" "" "" "" "508.3" "481.4" "535.5" "460.1" "450.9" "488.0" "471.1" "482.6" "647.1" "517.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8311576936421810338" "False" "High" "IsMasterProtein" "Q6ZN28" "Metastasis-associated in colon cancer protein 1 OS=Homo sapiens OX=9606 GN=MACC1 PE=1 SV=2" "0.000" "False" "21.889" "5" "4" "6" "4" "852" "96.6" "6.90" "18.76" "4" "signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding" "" "346389" "ENSG00000183742" "MACC1" "A8MUS5; B2RNR9; hsa:346389; Q6ZN28; Q6ZQN8; Q7Z5A5" "" "" "0" "0" "1.042" "1.052" "1.100" "1.159" "0.958" "1.092" "1.081" "0.980" "1.048" "452.2" "471.4" "475.9" "497.2" "524.1" "433.3" "493.8" "488.8" "443.2" "473.9" "" "" "" "" "" "" "" "" "" "" "363.2" "340.1" "378.0" "333.2" "362.4" "325.1" "345.8" "357.0" "443.2" "385.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6899043111177724007" "False" "High" "IsMasterProtein" "Q15208" "Serine/threonine-protein kinase 38 OS=Homo sapiens OX=9606 GN=STK38 PE=1 SV=1" "0.000" "False" "21.864" "10" "4" "5" "3" "465" "54.2" "7.15" "17.21" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "11329" "ENSG00000112079" "STK38" "hsa:11329; Q15208; Q503A1" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "Interactome of polycomb repressive complex 2 (PRC2)" "3" "0" "1.039" "0.965" "1.051" "1.120" "0.938" "1.049" "1.137" "0.986" "0.921" "337.7" "350.8" "325.8" "354.8" "378.2" "316.8" "354.1" "383.8" "332.8" "310.9" "" "" "" "" "" "" "" "" "" "" "271.2" "253.1" "258.8" "237.7" "261.6" "237.7" "247.9" "280.3" "332.8" "252.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6764322891151840328" "False" "High" "IsMasterProtein" "P19484" "Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3" "0.000" "False" "21.839" "14" "7" "10" "7" "476" "52.8" "6.29" "26.30" "7" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7942" "ENSG00000112561" "TFEB" "hsa:7942; P19484; Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8" "" "PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Type 2 papillary renal cell carcinoma; Autophagy in pancreatic ductal adenocarcinoma" "3" "0" "1.025" "0.940" "0.985" "0.981" "0.988" "0.964" "0.968" "1.019" "0.984" "660.7" "677.3" "621.0" "651.0" "647.8" "652.6" "637.1" "639.6" "673.0" "650.3" "" "" "" "" "" "" "" "" "" "" "530.7" "488.7" "493.3" "436.1" "448.0" "489.7" "446.1" "467.1" "673.0" "528.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8837747805973553035" "False" "High" "IsMasterProtein" "Q12778" "Forkhead box protein O1 OS=Homo sapiens OX=9606 GN=FOXO1 PE=1 SV=2" "0.000" "False" "21.831" "10" "6" "8" "6" "655" "69.6" "6.77" "17.45" "6" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16675, Pf16676" "2308" "ENSG00000150907" "FOXO1" "hsa:2308; O43523; Q12778; Q5VYC7; Q6NSK6" "Constitutive Signaling by AKT1 E17K in Cancer; MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; AKT-mediated inactivation of FOXO1A" "Androgen receptor signaling pathway; Energy metabolism; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Adipogenesis; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Copper homeostasis; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; NAD metabolism, sirtuins and aging; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; White fat cell differentiation; Somatroph axis (GH) and its relationship to dietary restriction and aging; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Kynurenine pathway and links to cell senescence; FOXA2 pathway; Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Warburg effect modulated by deubiquitinating enzymes and their substrates; Extrafollicular and follicular B cell activation by SARS-CoV-2; Primary ovarian insufficiency; Rubinstein-Taybi syndrome 1; ErbB signaling pathway" "52" "0" "0.912" "0.869" "0.949" "0.867" "0.820" "0.862" "0.903" "0.797" "0.810" "413.4" "377.0" "359.2" "392.2" "358.4" "339.1" "356.5" "373.1" "329.3" "334.9" "" "" "" "" "" "" "" "" "" "" "332.0" "272.0" "285.3" "262.8" "247.9" "254.5" "249.6" "272.5" "329.3" "272.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4323505555585634337" "False" "High" "IsMasterProtein" "Q9UKS7" "Zinc finger protein Helios OS=Homo sapiens OX=9606 GN=IKZF2 PE=1 SV=2" "0.000" "False" "21.826" "9" "4" "4" "2" "526" "59.5" "6.77" "16.16" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "22807" "ENSG00000030419" "IKZF2" "hsa:22807; Q53YJ5; Q6PQC5; Q6PQC6; Q6PQC7; Q6PQC8; Q6PQD0; Q6PQD1; Q8N6S1; Q9UKS7" "" "" "0" "0" "1.224" "1.463" "1.543" "1.071" "0.784" "1.132" "0.795" "0.908" "1.354" "12.4" "15.2" "18.2" "19.2" "13.3" "9.8" "14.1" "9.9" "11.3" "16.8" "" "" "" "" "" "" "" "" "" "" "10.0" "11.0" "14.5" "12.9" "9.2" "7.3" "9.9" "7.2" "11.3" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4117070045163199408" "False" "High" "IsMasterProtein" "Q6NUQ1" "RAD50-interacting protein 1 OS=Homo sapiens OX=9606 GN=RINT1 PE=1 SV=1" "0.000" "False" "21.819" "7" "5" "5" "5" "792" "90.6" "5.45" "16.60" "5" "cell cycle OR cell proliferation;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf04437" "60561" "ENSG00000135249" "RINT1" "hsa:60561; Q6NUQ1; Q75MG9; Q75MH0; Q96IW8; Q9H229; Q9HAD9" "COPI-dependent Golgi-to-ER retrograde traffic" "" "1" "0" "1.078" "0.943" "0.882" "0.877" "0.887" "0.938" "0.984" "0.965" "0.953" "253.8" "273.6" "239.4" "223.8" "222.7" "225.0" "238.0" "249.9" "245.0" "241.9" "" "" "" "" "" "" "" "" "" "" "203.9" "197.4" "190.2" "149.9" "154.0" "168.8" "166.7" "182.5" "245.0" "196.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657566489845177469" "False" "High" "IsMasterProtein" "Q969K3" "E3 ubiquitin-protein ligase RNF34 OS=Homo sapiens OX=9606 GN=RNF34 PE=1 SV=1" "0.000" "False" "21.809" "15" "4" "4" "4" "372" "41.6" "4.96" "13.65" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13920, Pf21272" "80196" "ENSG00000170633" "RNF34" "B7Z933; hsa:80196; Q8NG47; Q969K3; Q9H6W8" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TP53 Degradation" "" "2" "0" "1.213" "1.264" "1.272" "1.011" "1.043" "0.979" "1.294" "1.110" "1.031" "54.5" "66.1" "68.9" "69.3" "55.1" "56.8" "53.3" "70.6" "60.5" "56.2" "" "" "" "" "" "" "" "" "" "" "43.8" "47.7" "54.7" "46.4" "38.1" "42.6" "37.3" "51.5" "60.5" "45.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697554350722155722" "False" "High" "IsMasterProtein" "Q96B45" "BLOC-1-related complex subunit 7 OS=Homo sapiens OX=9606 GN=BORCS7 PE=1 SV=2" "0.000" "False" "21.800" "28" "2" "3" "2" "106" "11.7" "6.79" "13.58" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf16088" "119032" "ENSG00000166275" "BORCS7" "B2R488; B3KUW4; C9K0X3; hsa:119032; Q96B45" "" "" "0" "0" "0.940" "0.953" "1.033" "0.815" "0.860" "0.983" "0.894" "0.856" "0.998" "166.9" "157.0" "159.1" "172.5" "136.0" "143.6" "164.1" "149.2" "142.9" "166.6" "" "" "" "" "" "" "" "" "" "" "134.1" "113.3" "126.4" "115.6" "94.0" "107.7" "114.9" "109.0" "142.9" "135.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7506213950327089282" "False" "High" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "0.000" "False" "21.797" "14" "6" "8" "6" "465" "52.8" "6.70" "24.57" "6" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "Protein hydroxylation; HDMs demethylate histones" "" "2" "0" "1.005" "0.946" "0.976" "0.913" "1.018" "0.830" "0.847" "0.864" "0.906" "610.3" "613.4" "577.1" "595.7" "557.3" "621.0" "506.5" "517.0" "527.5" "553.2" "" "" "" "" "" "" "" "" "" "" "490.2" "442.6" "458.4" "399.1" "385.5" "465.9" "354.6" "377.6" "527.5" "449.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120565565592818035" "False" "High" "IsMasterProtein" "P23443" "Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2" "0.000" "False" "21.794" "10" "5" "7" "5" "525" "59.1" "6.65" "29.89" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6198" "ENSG00000108443" "RPS6KB1" "B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1; hsa:6198; P23443; Q7Z721" "mTORC1-mediated signalling" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Kit receptor signaling pathway; IL6 signaling pathway; BDNF-TrkB signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway" "42" "0" "0.939" "1.004" "1.028" "1.041" "0.910" "0.923" "0.951" "0.969" "0.979" "559.9" "525.9" "562.4" "575.6" "583.0" "509.6" "516.6" "532.6" "542.4" "548.2" "" "" "" "" "" "" "" "" "" "" "449.7" "379.4" "446.7" "385.7" "403.2" "382.3" "361.7" "388.9" "542.4" "445.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4223527727478599420" "False" "High" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "0.000" "False" "21.788" "6" "4" "4" "4" "816" "91.3" "6.25" "14.35" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf21245" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "Synthesis of PIPs at the Golgi membrane" "" "1" "0" "1.088" "1.013" "1.103" "1.026" "0.957" "1.062" "0.929" "1.011" "0.891" "185.8" "202.1" "188.2" "205.0" "190.6" "177.7" "197.2" "172.5" "187.7" "165.5" "" "" "" "" "" "" "" "" "" "" "149.2" "145.8" "149.5" "137.3" "131.8" "133.3" "138.1" "126.0" "187.7" "134.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "986054919885634239" "False" "High" "IsMasterProtein" "Q9NQY0" "Bridging integrator 3 OS=Homo sapiens OX=9606 GN=BIN3 PE=1 SV=1" "0.000" "False" "21.786" "25" "6" "9" "6" "253" "29.6" "7.47" "26.19" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf03114" "55909" "ENSG00000147439" "BIN3" "hsa:55909; Q9BVG2; Q9NQY0; Q9NVY9" "" "" "0" "0" "0.912" "0.838" "0.930" "0.948" "1.036" "0.908" "1.092" "0.887" "0.925" "411.8" "375.5" "344.9" "382.8" "390.3" "426.5" "374.1" "449.8" "365.4" "381.1" "" "" "" "" "" "" "" "" "" "" "330.8" "271.0" "274.0" "256.5" "269.9" "320.0" "261.9" "328.5" "365.4" "309.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909232235632679983" "False" "High" "IsMasterProtein" "Q13418" "Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2" "0.000" "False" "21.783" "17" "8" "10" "8" "452" "51.4" "8.07" "23.97" "8" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf07714, Pf12796" "3611" "ENSG00000166333" "ILK" "B7Z1I0; B7Z418; D3DQU0; hsa:3611; P57043; Q13418; Q68DZ3" "Localization of the PINCH-ILK-PARVIN complex to focal adhesions" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system; 2q37 copy number variation syndrome" "13" "0" "1.034" "0.997" "1.078" "1.074" "1.003" "1.049" "1.103" "1.122" "1.137" "757.6" "783.6" "755.1" "816.8" "813.9" "760.1" "794.4" "835.6" "849.8" "861.0" "" "" "" "" "" "" "" "" "" "" "608.5" "565.4" "599.8" "547.3" "562.9" "570.3" "556.2" "610.2" "849.8" "700.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3970443704612931563" "False" "High" "IsMasterProtein" "P36578" "Large ribosomal subunit protein uL4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5" "0.000" "False" "21.774" "11" "5" "7" "5" "427" "47.7" "11.06" "18.43" "5" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00573, Pf14374" "6124" "ENSG00000174444" "RPL4" "A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.097" "1.234" "1.168" "1.009" "1.016" "1.117" "0.978" "1.017" "1.058" "515.1" "564.8" "635.6" "601.4" "519.6" "523.4" "575.3" "503.6" "523.8" "545.0" "" "" "" "" "" "" "" "" "" "" "413.7" "407.6" "504.9" "402.9" "359.4" "392.7" "402.8" "367.8" "523.8" "443.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3289616204838975461" "False" "High" "IsMasterProtein" "P62851" "Small ribosomal subunit protein eS25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "0.000" "False" "21.762" "37" "5" "9" "5" "125" "13.7" "10.11" "29.83" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.984" "1.186" "1.106" "1.169" "1.104" "1.548" "1.145" "1.051" "1.103" "612.4" "602.5" "726.5" "677.3" "715.8" "676.1" "948.1" "700.9" "643.8" "675.6" "" "" "" "" "" "" "" "" "" "" "491.9" "434.7" "577.1" "453.8" "495.0" "507.3" "663.8" "511.9" "643.8" "549.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1523166315396082647" "False" "High" "IsMasterProtein" "P27815" "3',5'-cyclic-AMP phosphodiesterase 4A OS=Homo sapiens OX=9606 GN=PDE4A PE=1 SV=3" "0.000" "False" "21.758" "5" "3" "3" "3" "886" "98.1" "5.21" "10.56" "3" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00233, Pf18100" "5141" "ENSG00000065989" "PDE4A" "hsa:5141; O75522; O76092; P27815; Q16255; Q16691; Q5DM53; Q6PMT2; Q8IVA7; Q8WUQ3; Q9H3H2" "G alpha (s) signalling events; DARPP-32 events" "G protein signaling pathways; Phosphodiesterases in neuronal function; Sildenafil treatment" "5" "0" "1.032" "0.973" "0.997" "0.995" "0.992" "0.976" "0.937" "1.018" "1.054" "97.0" "100.1" "94.3" "96.7" "96.5" "96.2" "94.6" "90.8" "98.7" "102.2" "" "" "" "" "" "" "" "" "" "" "77.9" "72.2" "74.9" "64.8" "66.7" "72.2" "66.3" "66.3" "98.7" "83.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8392578490847645683" "False" "High" "IsMasterProtein" "Q9NR33" "DNA polymerase epsilon subunit 4 OS=Homo sapiens OX=9606 GN=POLE4 PE=1 SV=2" "0.000" "False" "21.746" "26" "2" "4" "2" "117" "12.2" "4.92" "14.75" "2" "DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "56655" "ENSG00000115350" "POLE4" "Q53TR2; Q9NR33" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "16" "0" "1.060" "1.065" "1.054" "1.047" "0.991" "1.065" "1.055" "0.977" "1.035" "304.7" "323.1" "324.4" "321.2" "319.1" "301.9" "324.4" "321.4" "297.7" "315.3" "" "" "" "" "" "" "" "" "" "" "244.7" "233.2" "257.7" "215.2" "220.7" "226.5" "227.1" "234.7" "297.7" "256.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869941848494998165" "False" "High" "IsMasterProtein" "O75170" "Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP6R2 PE=1 SV=2" "0.000" "False" "21.742" "7" "6" "6" "5" "966" "104.9" "4.87" "17.02" "6" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04499" "9701" "ENSG00000100239" "PPP6R2" "A6PVG3; B7Z7T3; hsa:9701; O75170; Q5U5P3; Q7Z2L2; Q7Z5G5; Q7Z731; Q9UGB9" "" "" "0" "0" "1.013" "1.086" "1.097" "1.033" "1.092" "0.998" "1.020" "1.030" "1.024" "361.6" "366.5" "392.8" "396.6" "373.7" "394.8" "361.1" "368.9" "372.7" "370.4" "" "" "" "" "" "" "" "" "" "" "290.5" "264.5" "312.1" "265.7" "258.4" "296.2" "252.8" "269.4" "372.7" "301.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643527966773386320" "False" "High" "IsMasterProtein" "Q8IWZ8" "SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2" "0.000" "False" "21.740" "9" "4" "4" "4" "645" "72.4" "7.61" "16.46" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "57794" "ENSG00000105705" "SUGP1" "hsa:57794; O60378; Q6P3X9; Q8IWZ8; Q8TCQ4; Q8WWT4; Q8WWT5; Q9NTG3" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.928" "0.962" "1.144" "1.051" "0.941" "0.992" "1.029" "1.052" "1.014" "243.9" "226.4" "234.7" "278.9" "256.4" "229.6" "241.9" "251.0" "256.5" "247.2" "" "" "" "" "" "" "" "" "" "" "195.9" "163.4" "186.4" "186.9" "177.3" "172.2" "169.4" "183.3" "256.5" "201.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2150748430854839914" "False" "High" "IsMasterProtein" "Q96JC1" "Vam6/Vps39-like protein OS=Homo sapiens OX=9606 GN=VPS39 PE=1 SV=2" "0.000" "False" "21.700" "8" "5" "6" "5" "886" "101.7" "6.99" "18.31" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00780, Pf10366, Pf10367" "23339" "ENSG00000166887" "VPS39" "hsa:23339; O94869; Q71SQ6; Q7Z3V3; Q96B93; Q96JC1; Q96RM0" "SARS-CoV-2 modulates autophagy" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "4" "0" "1.131" "1.018" "1.056" "1.116" "1.119" "1.002" "1.028" "0.983" "1.038" "284.1" "321.3" "289.1" "300.1" "317.0" "318.0" "284.5" "292.0" "279.3" "295.0" "" "" "" "" "" "" "" "" "" "" "228.2" "231.9" "229.6" "201.0" "219.3" "238.6" "199.2" "213.3" "279.3" "239.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-531095149826683174" "False" "High" "IsMasterProtein" "Q86WX3" "Active regulator of SIRT1 OS=Homo sapiens OX=9606 GN=RPS19BP1 PE=1 SV=1" "0.000" "False" "21.694" "28" "3" "3" "3" "136" "15.4" "10.74" "14.85" "3" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15684" "91582" "ENSG00000187051" "RPS19BP1" "B0QY96; hsa:91582; Q5JZA1; Q86WX3" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "1.248" "1.053" "1.137" "1.191" "1.056" "1.046" "1.133" "1.202" "1.128" "125.4" "156.5" "132.1" "142.6" "149.3" "132.5" "131.2" "142.1" "150.8" "141.5" "" "" "" "" "" "" "" "" "" "" "100.7" "113.0" "104.9" "95.5" "103.3" "99.4" "91.9" "103.8" "150.8" "115.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7211345083341158849" "False" "High" "IsMasterProtein" "Q15382" "GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1" "0.000" "False" "21.678" "31" "6" "8" "6" "184" "20.5" "5.92" "25.53" "6" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "6009" "ENSG00000106615" "RHEB" "B3KWN6; D3DX13; hsa:6009; Q15382; Q53Y56; Q99444" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Polycystic kidney disease pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway" "26" "0" "1.016" "0.967" "0.972" "0.986" "1.024" "0.980" "1.008" "0.972" "0.937" "1315.1" "1336.5" "1272.1" "1278.4" "1296.6" "1347.0" "1288.6" "1326.1" "1278.2" "1232.6" "" "" "" "" "" "" "" "" "" "" "1056.3" "964.4" "1010.4" "856.5" "896.7" "1010.7" "902.2" "968.4" "1278.2" "1002.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5062141414675458558" "False" "High" "IsMasterProtein" "Q9P0L0" "Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3" "0.000" "False" "21.653" "10" "2" "6" "1" "249" "27.9" "8.62" "23.84" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9218" "ENSG00000101558" "VAPA" "A6NDZ0; D3DUI3; hsa:9218; O75453; Q5U0E7; Q9P0L0; Q9UBZ2" "Neutrophil degranulation; Sphingolipid de novo biosynthesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "Exercise-induced circadian regulation; Cholesterol metabolism" "5" "0" "0.908" "0.919" "0.977" "0.913" "1.053" "0.963" "1.073" "1.062" "0.964" "149.3" "135.5" "137.3" "145.9" "136.4" "157.2" "143.9" "160.2" "158.6" "143.9" "" "" "" "" "" "" "" "" "" "" "119.9" "97.8" "109.1" "97.8" "94.3" "118.0" "100.7" "117.0" "158.6" "117.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7472508916157269106" "False" "High" "IsMasterProtein" "Q9H9P8" "L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3" "0.000" "False" "21.652" "11" "5" "8" "5" "463" "50.3" "8.15" "28.27" "5" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01266" "79944" "ENSG00000087299" "L2HGDH" "hsa:79944; Q9BRR1; Q9H9P8" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "Cerebral organic acidurias, including diseases" "2" "0" "1.125" "1.028" "1.029" "0.964" "0.966" "0.952" "1.021" "1.011" "1.000" "854.0" "960.4" "878.2" "878.7" "823.6" "824.6" "812.6" "871.8" "863.5" "853.7" "" "" "" "" "" "" "" "" "" "" "685.9" "693.0" "697.6" "588.7" "569.6" "618.7" "569.0" "636.7" "863.5" "694.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4160171774517724011" "False" "High" "IsMasterProtein" "P51452" "Dual specificity protein phosphatase 3 OS=Homo sapiens OX=9606 GN=DUSP3 PE=1 SV=1" "0.000" "False" "21.606" "21" "3" "4" "3" "185" "20.5" "7.80" "12.77" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00782" "1845" "ENSG00000108861" "DUSP3" "D3DX45; hsa:1845; P51452; Q5U0J1; Q8IYJ9" "ERKs are inactivated" "MAPK signaling pathway; Fragile X syndrome" "3" "0" "1.029" "0.909" "0.945" "0.998" "1.068" "1.127" "0.968" "0.944" "1.030" "239.8" "246.7" "218.0" "226.6" "239.3" "256.0" "270.1" "232.1" "226.5" "246.9" "" "" "" "" "" "" "" "" "" "" "192.6" "178.0" "173.2" "151.8" "165.5" "192.1" "189.1" "169.5" "226.5" "200.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "598569642609282214" "False" "High" "IsMasterProtein" "Q9BRS2" "Serine/threonine-protein kinase RIO1 OS=Homo sapiens OX=9606 GN=RIOK1 PE=1 SV=2" "0.000" "False" "21.589" "11" "5" "6" "5" "568" "65.5" "6.19" "14.20" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163" "83732" "ENSG00000124784" "RIOK1" "B2RB28; Q8NDC8; Q96NV9; Q9BRS2" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.995" "0.988" "1.080" "0.975" "0.956" "0.914" "1.023" "1.000" "1.036" "275.9" "274.4" "272.7" "298.0" "268.9" "263.8" "252.1" "282.4" "276.0" "285.7" "" "" "" "" "" "" "" "" "" "" "221.6" "198.0" "216.6" "199.6" "186.0" "197.9" "176.5" "206.2" "276.0" "232.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984641138409737976" "False" "High" "IsMasterProtein" "Q9BXK5" "Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1" "0.000" "False" "21.549" "14" "4" "5" "4" "485" "52.7" "4.44" "12.93" "4" "other biological processes" "other membranes;mitochondrion;nucleus" "enzyme regulator activity" "Pf00452" "23786" "ENSG00000099968" "BCL2L13" "B3KPE7; hsa:23786; Q96B37; Q96IB7; Q9BXK5; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3" "" "Regulation of apoptosis by parathyroid hormone-related protein; TAR syndrome" "2" "0" "0.837" "0.931" "1.012" "0.848" "0.930" "1.045" "0.908" "0.897" "0.872" "97.9" "82.0" "91.2" "99.1" "83.0" "91.1" "102.3" "88.9" "87.8" "85.3" "" "" "" "" "" "" "" "" "" "" "78.6" "59.1" "72.4" "66.4" "57.4" "68.3" "71.6" "64.9" "87.8" "69.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5364611794781451874" "False" "High" "IsMasterProtein" "P08575" "Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3" "0.000" "False" "21.548" "4" "5" "5" "5" "1306" "147.4" "6.15" "16.70" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00041, Pf00102, Pf12453, Pf12567" "5788" "ENSG00000081237; ENSG00000262418" "PTPRC" "A0A0A0MT22; A8K7W6; hsa:5788; P08575; Q16614; Q9H0Y6; X6R433" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Other semaphorin interactions" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulatory circuits of the STAT3 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; EPO receptor signaling; Interferon type I signaling pathways" "9" "0" "0.930" "0.927" "1.040" "0.965" "1.041" "0.897" "0.896" "0.951" "1.010" "177.5" "165.0" "164.5" "184.5" "171.3" "184.8" "159.3" "159.1" "168.9" "179.3" "" "" "" "" "" "" "" "" "" "" "142.6" "119.1" "130.7" "123.6" "118.5" "138.7" "111.5" "116.2" "168.9" "145.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6689030380433317187" "False" "High" "IsMasterProtein" "Q01543" "Friend leukemia integration 1 transcription factor OS=Homo sapiens OX=9606 GN=FLI1 PE=1 SV=1" "0.000" "False" "21.544" "13" "4" "4" "4" "452" "51.0" "7.06" "14.78" "4" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "2313" "ENSG00000151702" "FLI1" "B2R8H2; B4DFV4; B4DTC6; G3V183; hsa:2313; Q01543; Q14319; Q92480; Q9UE07" "Transcriptional regulation of granulopoiesis" "Hematopoietic stem cell differentiation" "2" "0" "0.972" "1.015" "0.965" "0.976" "0.933" "0.857" "0.877" "0.913" "0.972" "629.5" "612.1" "638.8" "607.4" "614.2" "587.5" "539.2" "552.2" "574.6" "612.0" "" "" "" "" "" "" "" "" "" "" "505.6" "441.7" "507.5" "407.0" "424.8" "440.8" "377.5" "403.3" "574.6" "497.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1124967282390941354" "False" "High" "IsMasterProtein" "Q9HB90" "Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1" "0.000" "False" "21.536" "13" "5" "5" "5" "399" "44.2" "5.10" "17.51" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "64121" "ENSG00000116954" "RRAGC" "hsa:64121; Q9H202; Q9H8Q8; Q9HB90" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "Target of rapamycin signaling; Orexin receptor pathway; 2q37 copy number variation syndrome" "10" "0" "1.017" "1.010" "0.947" "1.053" "1.079" "1.031" "1.060" "1.046" "1.027" "325.3" "330.8" "328.7" "308.2" "342.4" "350.9" "335.5" "345.0" "340.2" "334.0" "" "" "" "" "" "" "" "" "" "" "261.3" "238.7" "261.1" "206.5" "236.8" "263.3" "234.9" "251.9" "340.2" "271.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5593923735961542225" "False" "High" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "0.000" "False" "21.511" "36" "6" "10" "6" "176" "20.7" "6.34" "28.99" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "" "2" "0" "1.088" "0.993" "1.050" "1.018" "1.018" "0.938" "0.901" "0.973" "0.968" "270.6" "294.2" "268.7" "284.1" "275.4" "275.4" "253.7" "243.7" "263.2" "261.9" "" "" "" "" "" "" "" "" "" "" "217.3" "212.3" "213.5" "190.3" "190.5" "206.6" "177.7" "177.9" "263.2" "213.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1610110799858015964" "False" "High" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "0.000" "False" "21.504" "21" "4" "6" "4" "150" "16.8" "6.79" "21.32" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase" "9" "0" "1.066" "1.057" "1.104" "0.992" "1.047" "1.067" "1.104" "1.144" "1.087" "619.0" "659.6" "654.0" "683.5" "614.0" "648.2" "660.5" "683.1" "708.2" "672.7" "" "" "" "" "" "" "" "" "" "" "497.2" "476.0" "519.5" "457.9" "424.7" "486.4" "462.4" "498.8" "708.2" "547.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3846544257037738653" "False" "High" "IsMasterProtein" "Q96RT7" "Gamma-tubulin complex component 6 OS=Homo sapiens OX=9606 GN=TUBGCP6 PE=1 SV=3" "0.000" "False" "21.481" "3" "4" "4" "4" "1819" "200.4" "6.32" "12.39" "4" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf04130, Pf17681, Pf19340" "85378" "ENSG00000128159" "TUBGCP6" "hsa:85378; Q5JZ80; Q6PJ40; Q86YE9; Q96RT7; Q9BY91; Q9UGX3; Q9UGX4" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "1.146" "1.078" "1.134" "1.077" "1.208" "1.116" "1.065" "1.097" "1.139" "219.2" "251.2" "236.3" "248.7" "236.0" "264.9" "244.7" "233.4" "240.6" "249.8" "" "" "" "" "" "" "" "" "" "" "176.1" "181.2" "187.7" "166.6" "163.3" "198.7" "171.4" "170.5" "240.6" "203.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4348390061636338319" "False" "High" "IsMasterProtein" "Q9HAW4" "Claspin OS=Homo sapiens OX=9606 GN=CLSPN PE=1 SV=3" "0.000" "False" "21.442" "3" "3" "3" "3" "1339" "151.0" "4.82" "12.59" "3" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "63967" "ENSG00000092853" "CLSPN" "A6NFL4; hsa:63967; Q1RMC6; Q2KHM3; Q5VYG0; Q6P6H5; Q8IWI1; Q9HAW4" "Activation of ATR in response to replication stress; Ub-specific processing proteases; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins" "" "4" "0" "1.044" "0.959" "1.111" "0.931" "0.930" "1.216" "1.210" "1.095" "1.006" "192.9" "201.3" "185.0" "214.3" "179.6" "179.4" "234.6" "233.4" "211.2" "194.0" "" "" "" "" "" "" "" "" "" "" "154.9" "145.2" "146.9" "143.6" "124.2" "134.6" "164.2" "170.4" "211.2" "157.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3115833996025844865" "False" "High" "IsMasterProtein" "P19447" "General transcription and DNA repair factor IIH helicase/translocase subunit XPB OS=Homo sapiens OX=9606 GN=ERCC3 PE=1 SV=1" "0.000" "False" "21.434" "6" "3" "3" "3" "782" "89.2" "7.23" "11.63" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04851, Pf13625, Pf16203" "2071" "ENSG00000163161" "ERCC3" "hsa:2071; P19447; Q53QM0" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "33" "0" "0.819" "0.559" "1.345" "0.975" "0.911" "1.021" "1.106" "0.762" "1.111" "33.6" "27.6" "18.8" "45.2" "32.8" "30.6" "34.4" "37.2" "25.6" "37.4" "" "" "" "" "" "" "" "" "" "" "27.0" "19.9" "14.9" "30.3" "22.7" "23.0" "24.1" "27.2" "25.6" "30.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9168897576622990740" "False" "High" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "0.000" "False" "21.426" "31" "7" "9" "7" "180" "20.3" "4.96" "23.53" "7" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "" "2" "0" "1.019" "0.947" "1.013" "0.960" "0.998" "0.914" "0.963" "0.930" "0.974" "956.8" "975.4" "906.4" "969.1" "918.1" "954.8" "874.5" "921.7" "889.9" "932.0" "" "" "" "" "" "" "" "" "" "" "768.5" "703.8" "719.9" "649.3" "635.0" "716.3" "612.3" "673.1" "889.9" "757.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8973056022317677667" "False" "High" "IsMasterProtein" "Q9BVS4" "Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2" "0.000" "False" "21.420" "9" "4" "4" "4" "552" "63.2" "5.94" "10.40" "4" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163, Pf09202" "55781" "ENSG00000058729" "RIOK2" "D6RDI3; hsa:55781; Q9BVS4; Q9NUT0" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.953" "0.965" "1.082" "1.021" "1.019" "1.187" "1.150" "1.093" "1.075" "559.8" "533.4" "540.1" "605.4" "571.6" "570.5" "664.5" "643.6" "611.6" "601.8" "" "" "" "" "" "" "" "" "" "" "449.6" "384.9" "429.0" "405.6" "395.3" "428.0" "465.3" "470.0" "611.6" "489.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6469801124856573436" "False" "High" "IsMasterProtein" "P36404" "ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4" "0.000" "False" "21.407" "17" "3" "5" "3" "184" "20.9" "6.34" "18.06" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00025" "402" "ENSG00000213465" "ARL2" "G3V184; hsa:402; P36404; Q9BUK8" "Post-chaperonin tubulin folding pathway; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; RAS processing" "Joubert syndrome" "4" "0" "1.054" "1.019" "1.082" "1.050" "0.952" "0.954" "0.971" "0.938" "0.998" "358.8" "378.0" "365.6" "388.3" "376.7" "341.6" "342.3" "348.5" "336.7" "358.0" "" "" "" "" "" "" "" "" "" "" "288.2" "272.8" "290.4" "260.2" "260.5" "256.3" "239.6" "254.5" "336.7" "291.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2936218477733222076" "False" "High" "IsMasterProtein" "Q8N6T7" "NAD-dependent protein deacylase sirtuin-6 OS=Homo sapiens OX=9606 GN=SIRT6 PE=1 SV=2" "0.000" "False" "21.392" "13" "4" "6" "4" "355" "39.1" "9.19" "19.38" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "51548" "ENSG00000077463" "SIRT6" "B2RCD0; hsa:51548; O75291; Q6IAF5; Q6PK99; Q8N6T7; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1" "Pre-NOTCH Transcription and Translation; Processing of DNA double-strand break ends" "SREBF and miR33 in cholesterol and lipid homeostasis; NAD+ metabolism; NAD+ biosynthetic pathways; Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 10q11.21q11.23 copy number variation syndrome" "9" "0" "0.972" "0.952" "0.960" "1.014" "0.923" "0.940" "1.037" "0.878" "0.955" "209.7" "203.8" "199.6" "201.3" "212.6" "193.5" "197.1" "217.5" "184.0" "200.2" "" "" "" "" "" "" "" "" "" "" "168.4" "147.1" "158.5" "134.9" "147.0" "145.2" "138.0" "158.8" "184.0" "162.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833705581656825044" "False" "High" "IsMasterProtein" "Q96RT1" "Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2" "0.000" "False" "21.342" "3" "5" "5" "5" "1412" "158.2" "5.50" "18.01" "5" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00595, Pf13855" "55914" "ENSG00000112851" "ERBIN" "A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8; hsa:55914; Q1RMD0; Q86W38; Q96RT1; Q9NR18; Q9NW48; Q9ULJ5" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "Nucleotide-binding oligomerization domain (NOD) pathway; Nod-like receptor (NLR) signaling pathway; Pathways affected in adenoid cystic carcinoma" "26" "0" "1.030" "0.812" "0.910" "0.933" "1.005" "0.935" "0.991" "1.039" "0.971" "231.1" "238.0" "187.7" "210.3" "215.6" "232.2" "216.2" "229.0" "240.1" "224.3" "" "" "" "" "" "" "" "" "" "" "185.6" "171.8" "149.1" "140.9" "149.1" "174.2" "151.4" "167.3" "240.1" "182.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5817906340983341960" "False" "High" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "0.000" "False" "21.310" "29" "3" "12" "1" "95" "10.9" "5.50" "42.01" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "Formation of Incision Complex in GG-NER; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "TAR syndrome" "15" "0" "0.885" "0.914" "0.925" "1.047" "1.011" "0.985" "1.128" "0.950" "0.926" "249.9" "221.3" "228.4" "231.0" "261.7" "252.6" "246.0" "281.8" "237.5" "231.3" "" "" "" "" "" "" "" "" "" "" "200.7" "159.7" "181.4" "154.8" "181.0" "189.5" "172.3" "205.8" "237.5" "188.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4664258247594329003" "False" "High" "IsMasterProtein" "Q9H9B1" "Histone-lysine N-methyltransferase EHMT1 OS=Homo sapiens OX=9606 GN=EHMT1 PE=1 SV=4" "0.000" "False" "21.307" "6" "5" "5" "5" "1298" "141.4" "5.76" "16.29" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf05033, Pf12796, Pf21533" "79813" "ENSG00000181090" "EHMT1" "B1AQ58; B1AQ59; hsa:79813; Q86X08; Q8TCN7; Q96F53; Q96JF1; Q96KH4; Q9H9B1" "Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by E2F6; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines" "Histone modifications; MTHFR deficiency; Kleefstra syndrome" "8" "0" "1.248" "1.106" "1.246" "1.111" "1.126" "1.189" "1.369" "1.064" "1.017" "63.0" "78.6" "69.6" "78.5" "70.0" "70.9" "74.9" "86.2" "67.0" "64.0" "" "" "" "" "" "" "" "" "" "" "50.6" "56.7" "55.3" "52.6" "48.4" "53.2" "52.4" "63.0" "67.0" "52.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201911436176215" "False" "High" "IsMasterProtein" "Q13952" "Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3" "0.000" "False" "21.299" "9" "4" "5" "4" "458" "50.3" "6.10" "14.79" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "4802" "ENSG00000066136" "NFYC" "B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "" "5" "0" "0.915" "0.900" "1.030" "0.993" "0.906" "0.888" "0.873" "0.881" "0.979" "416.0" "380.7" "374.3" "428.6" "413.1" "377.1" "369.5" "363.1" "366.3" "407.3" "" "" "" "" "" "" "" "" "" "" "334.1" "274.7" "297.3" "287.2" "285.7" "282.9" "258.7" "265.2" "366.3" "331.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012550924560015135" "False" "High" "IsMasterProtein" "O43805" "Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2" "0.000" "False" "21.273" "35" "5" "6" "5" "119" "13.6" "5.38" "21.42" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "8636" "ENSG00000176101" "SSNA1" "hsa:8636; O43805; Q5VSG0; Q6FG70; Q9BVW8" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Ciliary landscape" "8" "0" "1.003" "0.909" "1.005" "1.021" "1.040" "1.046" "1.021" "0.875" "0.982" "1148.9" "1152.4" "1044.8" "1155.0" "1172.9" "1194.6" "1202.0" "1173.1" "1004.7" "1127.8" "" "" "" "" "" "" "" "" "" "" "922.8" "831.5" "829.9" "773.9" "811.2" "896.3" "841.6" "856.8" "1004.7" "917.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4950317330528062097" "False" "High" "IsMasterProtein" "Q92466" "DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1" "0.000" "False" "21.268" "10" "4" "4" "4" "427" "47.8" "9.47" "14.79" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "1643" "ENSG00000134574" "DDB2" "B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466" "Ub-specific processing proteases; TP53 Regulates Transcription of DNA Repair Genes; Dual Incision in GG-NER; Neddylation; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1040458896990308382" "False" "High" "IsMasterProtein" "Q9Y5J7" "Mitochondrial import inner membrane translocase subunit Tim9 OS=Homo sapiens OX=9606 GN=TIMM9 PE=1 SV=1" "0.000" "False" "21.260" "38" "3" "5" "3" "89" "10.4" "7.21" "17.80" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26520" "ENSG00000100575" "TIMM9" "B2R584; hsa:26520; Q9Y5J7" "Mitochondrial protein import; Mitochondrial protein degradation" "" "2" "0" "1.044" "1.087" "1.008" "1.039" "1.054" "0.962" "0.909" "0.967" "1.067" "237.3" "247.7" "258.0" "239.3" "246.4" "250.1" "228.2" "215.7" "229.4" "253.2" "" "" "" "" "" "" "" "" "" "" "190.6" "178.7" "205.0" "160.3" "170.4" "187.6" "159.8" "157.5" "229.4" "205.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5620405547330282270" "False" "High" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "0.000" "False" "21.241" "13" "9" "11" "8" "671" "74.3" "7.49" "28.34" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "0.979" "1.012" "0.993" "1.041" "0.843" "1.110" "1.083" "1.284" "1.024" "419.7" "410.9" "424.8" "416.7" "437.0" "353.8" "465.8" "454.5" "538.9" "429.7" "" "" "" "" "" "" "" "" "" "" "337.1" "296.5" "337.4" "279.2" "302.2" "265.4" "326.1" "331.9" "538.9" "349.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8657126207816692356" "False" "High" "IsMasterProtein" "O43422" "52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens OX=9606 GN=THAP12 PE=1 SV=2" "0.000" "False" "21.209" "9" "6" "6" "6" "761" "87.6" "5.86" "16.03" "6" "signal transduction;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf05485, Pf05699, Pf14291" "5612" "ENSG00000137492" "THAP12" "A8K728; hsa:5612; O43422; Q17RY9; Q8WTW1; Q9Y3Z4" "" "" "0" "0" "0.950" "0.939" "0.984" "0.908" "0.952" "0.891" "0.951" "1.019" "1.002" "347.0" "329.8" "325.9" "341.4" "315.2" "330.4" "309.2" "329.9" "353.7" "347.8" "" "" "" "" "" "" "" "" "" "" "278.7" "238.0" "258.9" "228.7" "218.0" "247.9" "216.5" "240.9" "353.7" "282.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7205134673462845767" "False" "High" "IsMasterProtein" "Q86Y91" "Kinesin-like protein KIF18B OS=Homo sapiens OX=9606 GN=KIF18B PE=1 SV=4" "0.000" "False" "21.185" "8" "6" "7" "5" "852" "93.0" "8.62" "16.44" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "146909" "ENSG00000186185" "KIF18B" "A0A0C4DGP2; A0A0C4DGP5; A6NJI2; B7ZM49; B9EGM8; D5L6I1; hsa:146909; Q86Y91" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "" "2" "1" "1.060" "1.093" "1.115" "1.115" "1.014" "1.221" "1.210" "1.082" "1.125" "366.5" "388.5" "400.6" "408.5" "408.5" "371.7" "447.5" "443.5" "396.7" "412.4" "" "" "" "" "" "" "" "" "" "" "294.4" "280.3" "318.2" "273.7" "282.5" "278.9" "313.3" "323.9" "396.7" "335.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-77584884133553683" "False" "High" "IsMasterProtein" "Q9UMY4" "Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12 PE=1 SV=4" "0.000" "False" "21.178" "37" "6" "6" "5" "162" "18.9" "8.44" "18.28" "6" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29934" "ENSG00000147164" "SNX12" "F8W8K5; hsa:29934; Q8WUG9; Q9UMY4" "" "" "0" "0" "1.090" "1.071" "1.037" "1.093" "1.022" "0.948" "0.992" "1.013" "1.062" "406.5" "443.1" "435.4" "421.4" "444.2" "415.3" "385.3" "403.3" "411.7" "431.7" "" "" "" "" "" "" "" "" "" "" "326.5" "319.7" "345.9" "282.3" "307.2" "311.6" "269.8" "294.5" "411.7" "351.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4890653308716064100" "False" "High" "IsMasterProtein" "Q9H981" "Actin-related protein 8 OS=Homo sapiens OX=9606 GN=ACTR8 PE=1 SV=2" "0.000" "False" "21.160" "9" "6" "9" "6" "624" "70.4" "7.78" "30.29" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf00022" "93973" "ENSG00000113812" "ACTR8" "B3KSW7; hsa:93973; Q8N566; Q9H663; Q9H981" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "1.012" "0.976" "0.972" "0.956" "1.025" "0.952" "0.970" "0.990" "1.020" "1208.8" "1223.1" "1179.5" "1175.4" "1156.2" "1239.1" "1151.1" "1172.8" "1196.9" "1233.5" "" "" "" "" "" "" "" "" "" "" "970.9" "882.5" "936.9" "787.5" "799.6" "929.7" "806.0" "856.5" "1196.9" "1003.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3739343134974919134" "False" "High" "IsMasterProtein" "Q92804" "TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1" "0.000" "False" "21.136" "6" "3" "11" "1" "592" "61.8" "8.02" "38.20" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8148" "ENSG00000270647; ENSG00000276833" "TAF15" "B2R837; hsa:8148; Q86X94; Q92751; Q92804" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "17q12 copy number variation syndrome" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "High" "Not Found" "Not Found" "Not Found" "1" "" "3341461915485741514" "False" "High" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "0.000" "False" "21.134" "8" "4" "5" "4" "420" "47.0" "8.73" "16.12" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "rRNA modification in the mitochondrion" "" "1" "0" "1.054" "0.902" "1.105" "1.091" "1.154" "1.208" "1.126" "1.075" "0.935" "70.1" "73.9" "63.2" "77.5" "76.5" "80.9" "84.7" "79.0" "75.3" "65.6" "" "" "" "" "" "" "" "" "" "" "56.3" "53.3" "50.2" "51.9" "52.9" "60.7" "59.3" "57.7" "75.3" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4255183124898333384" "False" "High" "IsMasterProtein" "Q9Y6G5" "COMM domain-containing protein 10 OS=Homo sapiens OX=9606 GN=COMMD10 PE=1 SV=1" "0.000" "False" "21.096" "33" "5" "6" "5" "202" "23.0" "6.54" "17.04" "5" "" "nucleus;other cell component" "" "Pf07258, Pf21672" "51397" "ENSG00000145781" "COMMD10" "D3DT07; hsa:51397; Q9P077; Q9Y6G5" "Neddylation" "" "1" "0" "1.121" "1.242" "1.069" "0.910" "1.021" "1.104" "1.102" "0.922" "1.079" "52.1" "58.4" "64.7" "55.7" "47.5" "53.2" "57.5" "57.4" "48.1" "56.2" "" "" "" "" "" "" "" "" "" "" "41.9" "42.2" "51.4" "37.3" "32.8" "39.9" "40.3" "41.9" "48.1" "45.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028441251658952013" "False" "High" "IsMasterProtein" "Q9H7L9" "Sin3 histone deacetylase corepressor complex component SDS3 OS=Homo sapiens OX=9606 GN=SUDS3 PE=1 SV=2" "0.000" "False" "21.094" "11" "4" "6" "4" "328" "38.1" "5.66" "15.07" "4" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08598" "64426" "ENSG00000111707" "SUDS3" "hsa:64426; Q4KMQ5; Q8N6H0; Q9H7L9; Q9H8D2" "NoRC negatively regulates rRNA expression; Potential therapeutics for SARS; Ub-specific processing proteases; HDACs deacetylate histones" "" "4" "0" "1.029" "1.065" "1.091" "1.045" "1.063" "1.059" "1.105" "1.060" "1.187" "312.8" "321.8" "333.2" "341.4" "327.0" "332.4" "331.4" "345.5" "331.6" "371.3" "" "" "" "" "" "" "" "" "" "" "251.2" "232.2" "264.7" "228.7" "226.1" "249.4" "232.0" "252.3" "331.6" "302.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2715683272122769400" "False" "High" "IsMasterProtein" "Q14197" "Large ribosomal subunit protein mL62 OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" "0.000" "False" "21.082" "23" "5" "5" "5" "206" "23.6" "10.07" "16.10" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00472" "3396" "ENSG00000167862" "MRPL58" "B2RAD1; hsa:3396; Q14197; Q53HM7; Q53Y11" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.028" "0.999" "0.964" "1.018" "1.073" "1.022" "0.980" "0.980" "1.008" "474.8" "488.2" "474.1" "457.7" "483.5" "509.6" "485.4" "465.2" "465.2" "478.6" "" "" "" "" "" "" "" "" "" "" "381.3" "352.2" "376.6" "306.7" "334.4" "382.4" "339.9" "339.8" "465.2" "389.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634316393020217319" "False" "High" "IsMasterProtein" "Q5VZE5" "N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1" "0.000" "False" "21.081" "9" "7" "9" "7" "725" "83.6" "7.05" "18.76" "7" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04112" "60560" "ENSG00000135040" "NAA35" "hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.990" "0.895" "0.945" "0.960" "0.928" "0.922" "0.998" "0.920" "0.973" "576.3" "570.5" "515.8" "544.5" "553.5" "534.8" "531.3" "575.4" "530.4" "560.8" "" "" "" "" "" "" "" "" "" "" "462.9" "411.6" "409.7" "364.8" "382.8" "401.3" "372.0" "420.2" "530.4" "456.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7605379253823960098" "False" "High" "IsMasterProtein" "Q96Q83" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 OS=Homo sapiens OX=9606 GN=ALKBH3 PE=1 SV=1" "0.000" "False" "21.080" "16" "4" "4" "4" "286" "33.4" "8.40" "14.76" "4" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf13532" "221120" "ENSG00000166199" "ALKBH3" "A6NDJ1; Q3SYI0; Q6NX57; Q96BU8; Q96Q83" "ALKBH3 mediated reversal of alkylation damage" "Direct reversal repair; 11p11.2 copy number variation syndrome" "3" "0" "1.192" "1.227" "1.080" "1.166" "1.259" "1.018" "1.042" "1.110" "1.236" "187.6" "223.5" "230.2" "202.5" "218.7" "236.1" "191.0" "195.5" "208.2" "231.8" "" "" "" "" "" "" "" "" "" "" "150.7" "161.3" "182.8" "135.7" "151.2" "177.2" "133.7" "142.8" "208.2" "188.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1130505086342919631" "False" "High" "IsMasterProtein" "Q99704" "Docking protein 1 OS=Homo sapiens OX=9606 GN=DOK1 PE=1 SV=1" "0.000" "False" "21.060" "11" "3" "4" "3" "481" "52.4" "6.47" "19.83" "3" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00169, Pf02174" "1796" "ENSG00000115325" "DOK1" "hsa:1796; O43204; Q53TY2; Q99704; Q9UHG6" "RET signaling; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1" "Kit receptor signaling pathway; VEGFA-VEGFR2 signaling; GDNF signaling" "5" "0" "1.046" "1.034" "1.158" "1.115" "1.218" "1.299" "1.252" "1.163" "1.205" "215.2" "225.2" "222.4" "249.2" "239.9" "262.0" "279.6" "269.3" "250.2" "259.3" "" "" "" "" "" "" "" "" "" "" "172.8" "162.5" "176.7" "167.0" "165.9" "196.6" "195.8" "196.7" "250.2" "210.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588774124192242024" "False" "High" "IsMasterProtein" "P54132" "RecQ-like DNA helicase BLM OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1" "0.000" "False" "21.046" "5" "7" "8" "6" "1417" "158.9" "7.49" "21.92" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382, Pf16124, Pf16202, Pf16204" "641" "ENSG00000197299" "BLM" "hsa:641; P54132; Q52M96" "Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Processive synthesis on the C-strand of the telomere" "Primary ovarian insufficiency" "18" "0" "1.114" "1.010" "1.038" "0.931" "1.078" "1.250" "1.223" "1.300" "1.087" "300.6" "334.7" "303.7" "312.1" "279.9" "323.9" "375.7" "367.7" "390.9" "326.6" "" "" "" "" "" "" "" "" "" "" "241.4" "241.5" "241.2" "209.1" "193.6" "243.0" "263.0" "268.6" "390.9" "265.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6553224162090552303" "False" "High" "IsMasterProtein" "Q9Y3A3" "MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1" "0.000" "False" "21.045" "20" "4" "5" "4" "225" "26.0" "5.78" "18.54" "4" "" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03637" "25843" "ENSG00000115540" "MOB4" "B4DML0; hsa:25843; Q53SE0; Q7Z4Y6; Q9H2P3; Q9H5J1; Q9Y3A3; Q9Y4T8" "" "" "0" "0" "1.053" "0.976" "1.050" "1.030" "1.007" "1.016" "1.020" "1.027" "1.032" "680.0" "715.8" "663.7" "714.4" "700.4" "685.1" "691.1" "693.6" "698.3" "701.7" "" "" "" "" "" "" "" "" "" "" "546.2" "516.5" "527.2" "478.6" "484.4" "514.0" "483.9" "506.5" "698.3" "570.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6663996802989080831" "False" "High" "IsMasterProtein" "Q15119" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial OS=Homo sapiens OX=9606 GN=PDK2 PE=1 SV=2" "0.000" "False" "21.040" "7" "3" "4" "3" "407" "46.1" "6.61" "14.84" "3" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5164" "ENSG00000005882" "PDK2" "A8K3A7; B3KNW0; hsa:5164; Q15119; Q6P515; Q9BS05" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "" "2" "0" "0.772" "0.719" "0.795" "0.757" "0.786" "0.784" "0.791" "0.751" "0.819" "455.3" "351.5" "327.3" "362.1" "344.8" "358.0" "356.9" "360.1" "341.9" "373.1" "" "" "" "" "" "" "" "" "" "" "365.7" "253.6" "260.0" "242.6" "238.4" "268.6" "249.9" "263.0" "341.9" "303.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5616510837335031809" "False" "High" "IsMasterProtein" "P15586" "N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3" "0.000" "False" "21.038" "7" "4" "6" "4" "552" "62.0" "8.31" "18.29" "4" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "2799" "ENSG00000135677" "GNS" "B4DYH8; hsa:2799; P15586; Q53F05" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Keratan sulfate degradation; MPS IIID - Sanfilippo syndrome D" "Glycosaminoglycan degradation" "5" "0" "1.026" "1.072" "1.037" "1.088" "0.995" "0.945" "0.889" "1.113" "0.971" "205.3" "210.7" "220.1" "212.9" "223.4" "204.2" "194.0" "182.5" "228.5" "199.3" "" "" "" "" "" "" "" "" "" "" "164.9" "152.1" "174.9" "142.6" "154.5" "153.2" "135.8" "133.3" "228.5" "162.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6161986969394420318" "False" "High" "IsMasterProtein" "O95081" "Arf-GAP domain and FG repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=AGFG2 PE=1 SV=2" "0.000" "False" "21.025" "10" "4" "4" "4" "481" "48.9" "9.11" "13.51" "4" "" "other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "3268" "ENSG00000106351" "AGFG2" "hsa:3268; O75429; O95081; Q96AB9; Q96GL4" "" "" "0" "0" "1.101" "1.145" "1.339" "1.141" "1.149" "1.067" "1.079" "1.216" "1.046" "129.7" "142.8" "148.5" "173.6" "148.0" "149.0" "138.3" "140.0" "157.7" "135.6" "" "" "" "" "" "" "" "" "" "" "104.2" "103.1" "118.0" "116.3" "102.4" "111.8" "96.9" "102.2" "157.7" "110.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3011217780081752783" "False" "High" "IsMasterProtein" "O43164" "E3 ubiquitin-protein ligase Praja-2 OS=Homo sapiens OX=9606 GN=PJA2 PE=1 SV=4" "0.000" "False" "21.024" "7" "3" "4" "3" "708" "78.2" "4.39" "16.01" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf13639" "9867" "ENSG00000198961" "PJA2" "A8K6U4; D3DSZ5; O43164; Q68D49; Q8N1G5" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.094" "0.947" "0.976" "1.083" "1.115" "1.012" "1.064" "1.147" "1.212" "101.5" "111.0" "96.1" "99.0" "109.9" "113.2" "102.7" "108.0" "116.4" "123.0" "" "" "" "" "" "" "" "" "" "" "81.5" "80.1" "76.3" "66.3" "76.0" "84.9" "71.9" "78.9" "116.4" "100.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107333921582106986" "False" "High" "IsMasterProtein" "Q9UPR3" "Nonsense-mediated mRNA decay factor SMG5 OS=Homo sapiens OX=9606 GN=SMG5 PE=1 SV=3" "0.000" "False" "21.018" "5" "4" "4" "4" "1016" "113.9" "5.91" "15.91" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23381" "ENSG00000198952" "SMG5" "D3DVB7; hsa:23381; Q5QJE7; Q659C7; Q8IXC0; Q8IY09; Q96IJ7; Q9UPR3" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "1.074" "1.016" "1.026" "0.978" "1.002" "0.997" "0.945" "0.996" "1.071" "375.4" "403.1" "381.3" "385.2" "367.1" "376.0" "374.2" "354.8" "373.7" "402.1" "" "" "" "" "" "" "" "" "" "" "301.5" "290.9" "302.9" "258.1" "253.9" "282.1" "262.0" "259.1" "373.7" "327.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4422070484711978078" "False" "High" "IsMasterProtein" "O95684" "Centrosomal protein 43 OS=Homo sapiens OX=9606 GN=CEP43 PE=1 SV=1" "0.000" "False" "21.011" "8" "3" "4" "3" "399" "43.0" "4.81" "16.30" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09398" "11116" "ENSG00000213066" "CEP43" "A8K1D1; B2R705; hsa:11116; O95684; Q49AI0; Q5R3F6; Q96EW1" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "11" "0" "0.917" "1.042" "1.080" "0.963" "1.196" "1.117" "1.155" "1.072" "1.083" "138.0" "126.5" "143.8" "149.1" "132.8" "165.0" "154.1" "159.4" "147.9" "149.5" "" "" "" "" "" "" "" "" "" "" "110.8" "91.3" "114.2" "99.9" "91.9" "123.8" "107.9" "116.4" "147.9" "121.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3645624783218300571" "False" "High" "IsMasterProtein" "Q96CG3" "TRAF-interacting protein with FHA domain-containing protein A OS=Homo sapiens OX=9606 GN=TIFA PE=1 SV=1" "0.000" "False" "20.993" "24" "5" "8" "5" "184" "21.4" "5.11" "24.72" "5" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00498" "92610" "ENSG00000145365" "TIFA" "hsa:92610; Q96CG3" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "4" "0" "0.983" "1.057" "0.877" "1.027" "0.972" "0.813" "0.880" "0.878" "0.893" "767.0" "754.3" "810.8" "672.7" "787.4" "745.6" "623.2" "674.8" "673.4" "685.0" "" "" "" "" "" "" "" "" "" "" "616.0" "544.3" "644.0" "450.7" "544.6" "559.4" "436.4" "492.8" "673.4" "557.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5628427782035597939" "False" "High" "IsMasterProtein" "P20336" "Ras-related protein Rab-3A OS=Homo sapiens OX=9606 GN=RAB3A PE=1 SV=1" "0.000" "False" "20.976" "16" "3" "8" "2" "220" "25.0" "5.03" "28.47" "3" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5864" "ENSG00000105649" "RAB3A" "A8K0J4; hsa:5864; P20336; Q9NYE1" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Sensory processing of sound by inner hair cells of the cochlea; Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy" "13" "0" "1.094" "1.033" "1.088" "1.116" "1.106" "1.046" "1.023" "1.145" "1.021" "239.0" "261.5" "246.9" "260.0" "266.7" "264.3" "250.0" "244.4" "273.6" "244.0" "" "" "" "" "" "" "" "" "" "" "191.9" "188.7" "196.1" "174.2" "184.4" "198.3" "175.1" "178.5" "273.6" "198.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6953685933096655099" "False" "High" "IsMasterProtein" "Q8N465" "D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3" "0.000" "False" "20.971" "12" "6" "7" "6" "521" "56.4" "7.99" "22.73" "6" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01565, Pf02913" "728294" "ENSG00000180902" "D2HGDH" "B4E3L6; E7ENP2; hsa:728294; Q6IQ24; Q8N465; Q8N5Q8" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2q37 copy number variation syndrome" "2" "0" "1.006" "0.977" "0.954" "1.001" "1.095" "0.974" "1.018" "0.988" "0.993" "459.7" "462.6" "449.1" "438.8" "460.2" "503.3" "447.9" "467.8" "454.0" "456.6" "" "" "" "" "" "" "" "" "" "" "369.3" "333.8" "356.7" "294.0" "318.3" "377.7" "313.6" "341.6" "454.0" "371.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630345377865006626" "False" "High" "IsMasterProtein" "Q9NVS9" "Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1" "0.000" "False" "20.938" "19" "4" "6" "4" "261" "30.0" "7.06" "21.69" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01243, Pf10590" "55163" "ENSG00000108439" "PNPO" "B4E0V0; B4E152; B4E1D7; D3DTT9; hsa:55163; Q9NVS9" "Vitamin B6 activation to pyridoxal phosphate" "Selenium micronutrient network; Vitamin B6-dependent and responsive disorders" "3" "0" "1.020" "0.832" "1.037" "1.009" "0.956" "1.102" "0.959" "0.773" "1.039" "184.3" "188.0" "153.3" "191.1" "185.9" "176.2" "203.0" "176.7" "142.5" "191.5" "" "" "" "" "" "" "" "" "" "" "148.0" "135.6" "121.7" "128.0" "128.6" "132.2" "142.1" "129.0" "142.5" "155.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3392290766648390097" "False" "High" "IsMasterProtein" "Q9UPP1" "Histone lysine demethylase PHF8 OS=Homo sapiens OX=9606 GN=PHF8 PE=1 SV=3" "0.000" "False" "20.919" "5" "5" "7" "5" "1060" "117.8" "8.72" "21.80" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf00628, Pf02373, Pf17811" "23133" "ENSG00000172943" "PHF8" "B3KMV4; B7Z911; hsa:23133; Q5H9U5; Q5JPR9; Q5JPS0; Q5JPS2; Q5JPS3; Q5VUJ4; Q7Z6D4; Q9HAH2; Q9UPP1" "HDMs demethylate histones" "Ectoderm differentiation" "2" "0" "1.167" "1.111" "1.048" "1.153" "0.986" "1.172" "1.141" "1.059" "1.087" "348.1" "406.4" "386.7" "364.7" "401.2" "343.3" "407.8" "397.3" "368.4" "378.5" "" "" "" "" "" "" "" "" "" "" "279.6" "293.2" "307.2" "244.4" "277.5" "257.5" "285.6" "290.1" "368.4" "307.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4788954663334132438" "False" "High" "IsMasterProtein" "Q9NWX6" "Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2" "0.000" "False" "20.892" "13" "4" "7" "4" "298" "34.8" "8.00" "24.83" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04446, Pf14413" "54974" "ENSG00000113272" "THG1L" "D3DQJ5; hsa:54974; Q53G12; Q7L5R3; Q9H0S2; Q9NWX6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.959" "1.023" "0.937" "0.953" "1.030" "0.894" "0.966" "0.974" "0.979" "1317.6" "1263.7" "1348.3" "1234.7" "1255.2" "1357.5" "1178.5" "1272.7" "1284.0" "1290.6" "" "" "" "" "" "" "" "" "" "" "1058.3" "911.8" "1071.0" "827.3" "868.1" "1018.5" "825.1" "929.5" "1284.0" "1049.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "908398624639479548" "False" "High" "IsMasterProtein" "P62913" "Large ribosomal subunit protein uL5 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "0.000" "False" "20.892" "17" "3" "6" "3" "178" "20.2" "9.60" "24.15" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "MET in type 1 papillary renal cell carcinoma; Cytoplasmic ribosomal proteins" "15" "0" "0.911" "1.363" "0.863" "1.095" "1.030" "1.034" "0.923" "0.961" "1.016" "161.5" "147.2" "220.2" "139.3" "176.9" "166.4" "167.1" "149.0" "155.2" "164.0" "" "" "" "" "" "" "" "" "" "" "129.7" "106.2" "174.9" "93.4" "122.3" "124.8" "117.0" "108.8" "155.2" "133.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811509789942253503" "False" "High" "IsMasterProtein" "Q7Z6M1" "Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1" "0.000" "False" "20.889" "18" "6" "8" "6" "372" "40.5" "6.25" "25.26" "6" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01344, Pf07646, Pf13415" "10244" "ENSG00000136933" "RABEPK" "A8K403; hsa:10244; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q7Z6M1; Q86Y76; Q9BWB1" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.940" "0.951" "1.070" "1.056" "1.019" "1.065" "0.995" "0.893" "1.100" "272.8" "256.3" "259.3" "291.8" "287.9" "278.0" "290.4" "271.5" "243.6" "299.9" "" "" "" "" "" "" "" "" "" "" "219.1" "184.9" "206.0" "195.5" "199.1" "208.6" "203.4" "198.3" "243.6" "243.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4761760755167772661" "False" "High" "IsMasterProtein" "Q9GZR2" "RNA exonuclease 4 OS=Homo sapiens OX=9606 GN=REXO4 PE=1 SV=2" "0.000" "False" "20.848" "14" "5" "5" "5" "422" "46.6" "9.77" "20.15" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00929" "57109" "ENSG00000148300; ENSG00000280706" "REXO4" "B2RAT2; hsa:57109; Q5T8S4; Q5T8S5; Q5T8S6; Q9GZR2; Q9GZW3" "" "" "0" "0" "0.948" "1.024" "0.891" "0.954" "0.951" "0.797" "0.901" "0.908" "0.942" "641.1" "607.7" "656.4" "571.5" "611.4" "609.6" "511.0" "577.5" "582.2" "604.1" "" "" "" "" "" "" "" "" "" "" "515.0" "438.5" "521.4" "382.9" "422.8" "457.4" "357.8" "421.7" "582.2" "491.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "680199301258843894" "False" "High" "IsMasterProtein" "O95229" "ZW10 interactor OS=Homo sapiens OX=9606 GN=ZWINT PE=1 SV=2" "0.000" "False" "20.836" "20" "5" "7" "5" "277" "31.3" "5.15" "19.02" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15556" "11130" "ENSG00000122952" "ZWINT" "A6NNV6; hsa:11130; O95229; Q0D2I3; Q9BWD0" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.061" "0.882" "1.118" "1.010" "0.987" "1.350" "1.240" "1.264" "1.077" "367.1" "389.5" "323.7" "410.2" "370.8" "362.5" "495.7" "455.3" "464.1" "395.5" "" "" "" "" "" "" "" "" "" "" "294.8" "281.0" "257.1" "274.8" "256.4" "271.9" "347.0" "332.5" "464.1" "321.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2810950685469585295" "False" "High" "IsMasterProtein" "Q2TBE0" "CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4" "0.000" "False" "20.817" "5" "5" "6" "5" "894" "103.7" "8.65" "22.21" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf04676, Pf04677" "143884" "ENSG00000152404" "CWF19L2" "A4FU66; A4FU67; A4FU68; A8KAD6; hsa:143884; Q2TBE0; Q6PHW1; Q96MI1" "mRNA Splicing - Major Pathway" "" "1" "0" "1.034" "1.039" "1.082" "1.048" "1.073" "1.053" "1.143" "1.084" "1.046" "592.1" "612.5" "615.0" "640.5" "620.3" "635.1" "623.3" "676.7" "641.9" "619.6" "" "" "" "" "" "" "" "" "" "" "475.6" "442.0" "488.5" "429.1" "429.0" "476.5" "436.4" "494.2" "641.9" "503.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246140782840633700" "False" "High" "IsMasterProtein" "Q96B01" "RAD51-associated protein 1 OS=Homo sapiens OX=9606 GN=RAD51AP1 PE=1 SV=1" "0.000" "False" "20.813" "22" "8" "8" "8" "352" "38.4" "9.11" "22.29" "8" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15696" "10635" "ENSG00000111247" "RAD51AP1" "A8K7D3; hsa:10635; O43403; Q7Z779; Q96B01" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "" "8" "0" "1.034" "0.983" "1.038" "0.947" "0.978" "1.015" "1.097" "1.014" "0.956" "261.8" "270.6" "257.3" "271.6" "247.9" "256.0" "265.7" "287.1" "265.4" "250.1" "" "" "" "" "" "" "" "" "" "" "210.3" "195.2" "204.4" "182.0" "171.4" "192.1" "186.0" "209.7" "265.4" "203.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8771434071682940528" "False" "High" "IsMasterProtein" "O95294" "RasGAP-activating-like protein 1 OS=Homo sapiens OX=9606 GN=RASAL1 PE=1 SV=3" "0.000" "False" "20.772" "5" "4" "4" "4" "804" "90.0" "6.51" "15.07" "4" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "8437" "ENSG00000111344" "RASAL1" "B7ZKM4; C9JFK5; F8VQX1; hsa:8437; O95294; Q52M03; Q59H24; Q96CC7" "Regulation of RAS by GAPs" "Ras signaling" "2" "0" "1.024" "1.002" "1.089" "0.977" "0.968" "1.066" "0.991" "1.047" "0.972" "483.6" "495.3" "484.5" "526.6" "472.4" "468.2" "515.4" "479.5" "506.2" "470.3" "" "" "" "" "" "" "" "" "" "" "388.4" "357.4" "384.9" "352.8" "326.7" "351.3" "360.9" "350.2" "506.2" "382.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5327705833801287144" "False" "High" "IsMasterProtein" "Q96EP0" "E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens OX=9606 GN=RNF31 PE=1 SV=1" "0.000" "False" "20.766" "4" "4" "4" "4" "1072" "119.6" "6.57" "10.36" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01485, Pf09409, Pf16678, Pf18091, Pf18486" "55072" "ENSG00000092098; ENSG00000285152" "RNF31" "A0A962; Q86VI2; Q8TEI0; Q96EP0; Q96GB4; Q96NF1; Q9H5F1; Q9NWD2" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "" "3" "0" "0.682" "0.673" "0.940" "0.743" "0.522" "0.630" "0.618" "0.721" "0.850" "19.5" "13.3" "13.1" "18.4" "14.5" "10.2" "12.3" "12.1" "14.1" "16.6" "" "" "" "" "" "" "" "" "" "" "15.7" "9.6" "10.4" "12.3" "10.0" "7.7" "8.6" "8.8" "14.1" "13.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8831328934271129534" "False" "High" "IsMasterProtein" "Q92733" "Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1" "0.000" "False" "20.743" "14" "5" "7" "5" "491" "52.4" "5.10" "24.35" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf10253" "5546" "ENSG00000143294" "PRCC" "A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733" "mRNA Splicing - Major Pathway" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; IL-18 signaling pathway" "4" "0" "1.000" "1.050" "1.041" "0.965" "0.967" "0.992" "0.969" "0.992" "1.028" "638.6" "638.8" "670.3" "664.5" "616.5" "617.4" "633.2" "618.7" "633.2" "656.2" "" "" "" "" "" "" "" "" "" "" "512.9" "460.9" "532.5" "445.2" "426.4" "463.2" "443.3" "451.9" "633.2" "533.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3728877322360888626" "False" "High" "IsMasterProtein" "P62854" "Small ribosomal subunit protein eS26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3" "0.000" "False" "20.733" "21" "2" "5" "2" "115" "13.0" "11.00" "19.24" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01283" "6231" "ENSG00000197728" "RPS26" "hsa:6231; P02383; P62854; P70394; Q06722; Q3MHD8; Q6IRY4" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.028" "1.083" "1.012" "1.083" "1.010" "1.017" "1.033" "1.068" "1.072" "464.0" "477.0" "502.4" "469.7" "502.7" "468.6" "471.7" "479.3" "495.6" "497.3" "" "" "" "" "" "" "" "" "" "" "372.7" "344.2" "399.1" "314.7" "347.7" "351.6" "330.3" "350.0" "495.6" "404.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779447610884953183" "False" "High" "IsMasterProtein" "Q9NPD8" "Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens OX=9606 GN=UBE2T PE=1 SV=1" "0.000" "False" "20.727" "29" "6" "9" "6" "197" "22.5" "7.99" "25.82" "6" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00179" "29089" "ENSG00000077152" "UBE2T" "hsa:29089; Q2TU36; Q9NPD8" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Fanconi Anemia Pathway" "Gastric cancer network 2" "3" "0" "1.044" "1.087" "0.998" "0.968" "0.986" "1.053" "1.109" "1.052" "0.998" "846.0" "883.1" "919.6" "844.1" "818.9" "834.4" "891.0" "938.5" "889.7" "844.4" "" "" "" "" "" "" "" "" "" "" "679.5" "637.2" "730.5" "565.5" "566.3" "626.0" "623.8" "685.4" "889.7" "686.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3822770652306198826" "False" "High" "IsMasterProtein" "Q6PI47" "BTB/POZ domain-containing protein KCTD18 OS=Homo sapiens OX=9606 GN=KCTD18 PE=1 SV=2" "0.000" "False" "20.715" "10" "3" "3" "3" "426" "46.7" "9.10" "11.94" "3" "cell organization and biogenesis" "" "" "Pf02214, Pf19321" "130535" "ENSG00000155729" "KCTD18" "hsa:130535; Q53T21; Q6NW26; Q6PCD8; Q6PI47; Q8N9B7; Q96N73" "" "" "0" "0" "0.811" "0.929" "0.957" "0.935" "0.928" "1.064" "0.930" "0.902" "0.974" "159.4" "129.2" "148.1" "152.6" "148.9" "147.8" "169.6" "148.2" "143.7" "155.3" "" "" "" "" "" "" "" "" "" "" "128.0" "93.2" "117.6" "102.2" "103.0" "110.9" "118.7" "108.2" "143.7" "126.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6246281522193444266" "False" "High" "IsMasterProtein" "O60573" "Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1" "0.000" "False" "20.675" "18" "3" "5" "3" "245" "28.3" "8.88" "17.83" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "9470" "ENSG00000135930" "EIF4E2" "B8ZZJ9; hsa:9470; O60573; O75349" "ISG15 antiviral mechanism" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance" "4" "0" "0.920" "1.017" "0.858" "0.772" "0.946" "0.735" "1.036" "0.944" "0.889" "251.5" "231.3" "255.8" "215.7" "194.2" "237.8" "184.9" "260.4" "237.3" "223.5" "" "" "" "" "" "" "" "" "" "" "202.0" "166.9" "203.2" "144.5" "134.3" "178.4" "129.5" "190.2" "237.3" "181.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505612402410571852" "False" "High" "IsMasterProtein" "P17900" "Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4" "0.000" "False" "20.670" "23" "5" "9" "5" "193" "20.8" "5.31" "28.44" "5" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf02221" "2760" "ENSG00000196743" "GM2A" "B2R699; D3DQH6; hsa:2760; P17900; Q14426; Q14428; Q6LBL5" "Neutrophil degranulation; Glycosphingolipid catabolism" "Degradation pathway of sphingolipids, including diseases" "3" "0" "1.000" "1.022" "0.973" "1.031" "1.034" "0.994" "1.039" "1.019" "1.024" "1192.5" "1192.0" "1218.9" "1160.1" "1229.5" "1233.4" "1185.9" "1238.6" "1214.9" "1221.2" "" "" "" "" "" "" "" "" "" "" "957.8" "860.1" "968.2" "777.3" "850.3" "925.4" "830.3" "904.5" "1214.9" "993.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2025748717046247647" "False" "High" "IsMasterProtein" "Q8IV63" "Serine/threonine-protein kinase VRK3 OS=Homo sapiens OX=9606 GN=VRK3 PE=1 SV=2" "0.000" "False" "20.666" "11" "5" "5" "5" "474" "52.8" "9.04" "16.58" "5" "signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13240" "51231" "ENSG00000105053" "VRK3" "A6NEG5; A8KA53; hsa:51231; Q502Y2; Q8IV63; Q9P2V8" "ERKs are inactivated" "" "1" "0" "1.041" "1.069" "1.130" "1.139" "1.080" "1.068" "0.992" "1.051" "1.099" "399.9" "416.4" "427.5" "451.8" "455.4" "431.8" "427.0" "396.7" "420.4" "439.6" "" "" "" "" "" "" "" "" "" "" "321.2" "300.4" "339.6" "302.7" "315.0" "324.0" "298.9" "289.7" "420.4" "357.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9059271771169400119" "False" "High" "IsMasterProtein" "Q9UBK9" "Protein UXT OS=Homo sapiens OX=9606 GN=UXT PE=1 SV=1" "0.000" "False" "20.659" "25" "4" "5" "4" "157" "18.2" "7.59" "18.25" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "8409" "ENSG00000126756" "UXT" "A0A0C4DFR8; B2R561; hsa:8409; Q5JZG3; Q9UBK9; Q9Y6E5" "Transcriptional Regulation by E2F6" "" "1" "0" "0.940" "1.048" "0.908" "0.758" "1.008" "0.822" "0.856" "0.908" "0.865" "265.8" "249.8" "278.6" "241.3" "201.6" "267.9" "218.6" "227.5" "241.4" "230.0" "" "" "" "" "" "" "" "" "" "" "213.5" "180.2" "221.3" "161.7" "139.4" "201.0" "153.0" "166.1" "241.4" "187.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7638543548033193713" "False" "High" "IsMasterProtein" "Q00765" "Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3" "0.000" "False" "20.653" "19" "4" "6" "4" "189" "21.5" "8.10" "17.60" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf03134" "7905" "ENSG00000129625" "REEP5" "B7Z681; D3DT04; hsa:7905; Q00765; Q04198; Q5QGT0; Q9BWH9" "" "" "0" "0" "0.945" "0.910" "0.861" "0.804" "0.833" "0.722" "0.778" "0.813" "0.862" "646.0" "610.6" "588.0" "556.0" "519.7" "538.1" "466.4" "502.5" "524.9" "556.7" "" "" "" "" "" "" "" "" "" "" "518.9" "440.6" "467.1" "372.5" "359.4" "403.7" "326.5" "366.9" "524.9" "452.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3045251361027418727" "False" "High" "IsMasterProtein" "O43237" "Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1" "0.000" "False" "20.652" "13" "5" "5" "5" "492" "54.1" "6.38" "15.82" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "1783" "ENSG00000135720" "DYNC1LI2" "A8K6V1; B4DZP4; hsa:1783; O43237; Q8TAT3" "Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "14" "0" "0.980" "0.901" "0.959" "0.967" "0.940" "1.049" "0.988" "0.921" "0.914" "103.4" "101.3" "93.2" "99.2" "100.0" "97.2" "108.5" "102.2" "95.2" "94.5" "" "" "" "" "" "" "" "" "" "" "83.1" "73.1" "74.0" "66.5" "69.1" "72.9" "76.0" "74.6" "95.2" "76.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1355108408195266018" "False" "High" "IsMasterProtein" "Q6NZ67" "Mitotic-spindle organizing protein 2B OS=Homo sapiens OX=9606 GN=MZT2B PE=1 SV=1" "0.000" "False" "20.647" "23" "2" "3" "1" "158" "16.2" "10.15" "15.98" "2" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "80097" "ENSG00000152082; ENSG00000292119" "MZT2B" "hsa:80097; Q6NZ67; Q96CG4" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "" "2" "1" "1.134" "1.039" "1.158" "1.067" "1.030" "1.103" "1.012" "1.112" "1.122" "234.5" "265.8" "243.5" "271.4" "250.2" "241.5" "258.7" "237.3" "260.7" "263.1" "" "" "" "" "" "" "" "" "" "" "188.3" "191.8" "193.4" "181.9" "173.1" "181.2" "181.1" "173.3" "260.7" "213.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686593457953999194" "False" "High" "IsMasterProtein" "P45985" "Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1" "0.000" "False" "20.641" "14" "4" "6" "4" "399" "44.3" "8.07" "16.66" "4" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6416" "ENSG00000065559" "MAP2K4" "B2R7N7; B3KYB2; D3DTS5; hsa:6416; P45985; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; PDGF pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "35" "0" "0.922" "0.914" "1.007" "0.976" "0.926" "0.873" "0.908" "0.882" "0.981" "233.1" "214.9" "213.1" "234.7" "227.5" "215.8" "203.4" "211.6" "205.7" "228.7" "" "" "" "" "" "" "" "" "" "" "187.3" "155.1" "169.3" "157.2" "157.4" "161.9" "142.4" "154.6" "205.7" "185.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892501601992705752" "False" "High" "IsMasterProtein" "Q5K651" "Sterile alpha motif domain-containing protein 9 OS=Homo sapiens OX=9606 GN=SAMD9 PE=1 SV=1" "0.000" "False" "20.641" "4" "5" "5" "5" "1589" "184.2" "7.83" "18.02" "5" "cell organization and biogenesis;stress response;transport" "cytosol;other cell component" "" "Pf00536" "54809" "ENSG00000205413" "SAMD9" "A2RU68; hsa:54809; Q5K649; Q5K651; Q6P080; Q75N21; Q8IVG6; Q9NXS8" "" "" "0" "0" "1.090" "1.017" "1.225" "1.129" "1.171" "1.066" "1.057" "1.157" "1.077" "361.7" "394.1" "367.9" "443.2" "408.3" "423.5" "385.6" "382.3" "418.3" "389.5" "" "" "" "" "" "" "" "" "" "" "290.5" "284.3" "292.2" "297.0" "282.4" "317.8" "270.0" "279.2" "418.3" "316.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6665456693960719485" "False" "High" "IsMasterProtein" "Q86V88" "Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1" "0.000" "False" "20.640" "27" "4" "7" "4" "176" "20.1" "6.39" "17.99" "4" "" "" "other molecular function" "Pf12689" "145553" "ENSG00000213920; ENSG00000285200" "MDP1" "hsa:145553; Q86V88; Q86Y84; Q8NAD9" "" "" "0" "0" "1.117" "1.044" "1.083" "1.077" "1.115" "1.070" "1.073" "1.062" "1.132" "404.6" "451.9" "422.2" "438.4" "435.6" "450.9" "432.8" "434.3" "429.6" "457.9" "" "" "" "" "" "" "" "" "" "" "324.9" "326.1" "335.4" "293.7" "301.3" "338.3" "303.0" "317.2" "429.6" "372.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1347928425928225454" "False" "High" "IsMasterProtein" "O60925" "Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2" "0.000" "False" "20.639" "47" "5" "7" "5" "122" "14.2" "6.81" "21.67" "5" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "5201" "ENSG00000113068" "PFDN1" "B2RD02; hsa:5201; O60925; Q53F95; Q96EX6" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.081" "1.064" "1.062" "0.971" "1.030" "1.051" "1.024" "1.013" "0.971" "954.8" "1032.1" "1015.7" "1013.8" "927.2" "983.5" "1003.5" "978.0" "967.3" "927.5" "" "" "" "" "" "" "" "" "" "" "766.9" "744.7" "806.8" "679.3" "641.3" "737.9" "702.6" "714.2" "967.3" "754.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8151909637929937359" "False" "High" "IsMasterProtein" "Q14554" "Protein disulfide-isomerase A5 OS=Homo sapiens OX=9606 GN=PDIA5 PE=1 SV=1" "0.000" "False" "20.637" "9" "5" "5" "5" "519" "59.6" "7.91" "16.53" "5" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00085" "10954" "ENSG00000065485" "PDIA5" "D3DN95; hsa:10954; Q14554; Q9BV43" "XBP1(S) activates chaperone genes" "" "1" "0" "0.937" "0.908" "0.870" "0.986" "0.922" "0.892" "0.904" "1.042" "0.928" "179.4" "168.0" "163.0" "156.1" "176.8" "165.5" "160.1" "162.1" "187.0" "166.5" "" "" "" "" "" "" "" "" "" "" "144.1" "121.3" "129.5" "104.6" "122.3" "124.2" "112.1" "118.4" "187.0" "135.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5887664116474982474" "False" "High" "IsMasterProtein" "Q9H6E4" "Coiled-coil domain-containing protein 134 OS=Homo sapiens OX=9606 GN=CCDC134 PE=1 SV=1" "0.000" "False" "20.626" "23" "4" "4" "4" "229" "26.5" "8.85" "16.35" "4" "developmental processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf15002" "79879" "ENSG00000100147" "CCDC134" "hsa:79879; Q9H6E4" "" "" "0" "0" "1.017" "0.942" "0.928" "0.961" "1.072" "0.973" "1.106" "1.119" "0.983" "363.6" "369.6" "342.5" "337.5" "349.5" "389.9" "353.7" "402.3" "407.0" "357.3" "" "" "" "" "" "" "" "" "" "" "292.1" "266.7" "272.0" "226.2" "241.7" "292.5" "247.7" "293.8" "407.0" "290.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8890451219668255439" "False" "High" "IsMasterProtein" "Q9NZC9" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1" "0.000" "False" "20.582" "8" "6" "6" "6" "954" "105.9" "9.06" "15.00" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07443" "50485" "ENSG00000138375" "SMARCAL1" "A6NEH0; hsa:50485; Q53R00; Q96AY1; Q9NXQ5; Q9NZC9; Q9UFH3; Q9UI93" "" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "2" "0" "1.076" "1.038" "1.158" "1.106" "1.340" "1.028" "1.021" "1.215" "1.111" "495.7" "533.4" "514.6" "574.0" "548.0" "664.1" "509.7" "506.0" "602.4" "550.6" "" "" "" "" "" "" "" "" "" "" "398.2" "384.9" "408.8" "384.6" "379.0" "498.2" "356.9" "369.5" "602.4" "447.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2247702318764912013" "False" "High" "IsMasterProtein" "Q8NI22" "Multiple coagulation factor deficiency protein 2 OS=Homo sapiens OX=9606 GN=MCFD2 PE=1 SV=1" "0.000" "False" "20.573" "25" "2" "3" "2" "146" "16.4" "4.63" "11.60" "2" "transport" "other membranes;ER/Golgi" "other molecular function" "Pf13499" "90411" "ENSG00000180398" "MCFD2" "A8K7W2; D6W5A9; E9PD95; hsa:90411; Q53SS3; Q68D61; Q8N3M5; Q8NI22" "COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "" "3" "0" "0.992" "1.100" "1.268" "1.070" "1.331" "1.298" "1.255" "1.111" "1.212" "95.0" "94.2" "104.5" "120.5" "101.6" "126.4" "123.3" "119.3" "105.5" "115.1" "" "" "" "" "" "" "" "" "" "" "76.3" "68.0" "83.0" "80.7" "70.3" "94.8" "86.3" "87.1" "105.5" "93.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8778470671322458913" "False" "High" "IsMasterProtein" "Q71UI9" "Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3" "0.000" "False" "20.570" "31" "4" "9" "2" "128" "13.5" "10.58" "29.62" "4" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "94239" "ENSG00000105968" "H2AZ2" "A6NFA8; A6NKY0; A6NN01; A8MQC5; hsa:94239; Q59GV8; Q6PK98; Q71UI9" "Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "35" "0" "0.947" "0.987" "1.007" "0.897" "0.941" "1.023" "1.083" "0.996" "1.002" "875.9" "829.4" "865.0" "882.1" "785.6" "824.6" "895.8" "948.8" "872.7" "877.5" "" "" "" "" "" "" "" "" "" "" "703.5" "598.5" "687.1" "591.0" "543.3" "618.7" "627.2" "692.9" "872.7" "713.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3197858597980699967" "False" "High" "IsMasterProtein" "Q9HA64" "Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2" "0.000" "False" "20.563" "20" "5" "7" "5" "309" "34.4" "7.33" "13.48" "5" "protein metabolism;other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf03881" "79672" "ENSG00000141560" "FN3KRP" "hsa:79672; Q969F4; Q9H0U7; Q9HA64" "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" "" "1" "0" "1.130" "1.042" "1.032" "1.180" "1.165" "1.253" "1.247" "1.145" "1.062" "174.0" "196.6" "181.4" "179.7" "205.4" "202.7" "218.0" "217.0" "199.3" "184.9" "" "" "" "" "" "" "" "" "" "" "139.8" "141.9" "144.1" "120.4" "142.0" "152.1" "152.6" "158.5" "199.3" "150.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4646306898255403066" "False" "High" "IsMasterProtein" "Q96FF9" "Sororin OS=Homo sapiens OX=9606 GN=CDCA5 PE=1 SV=1" "0.000" "False" "20.552" "14" "4" "5" "4" "252" "27.6" "9.61" "17.51" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09666" "113130" "ENSG00000146670" "CDCA5" "A8K625; hsa:113130; Q96FF9" "Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Establishment of Sister Chromatid Cohesion" "" "3" "0" "1.066" "1.051" "0.957" "0.978" "0.960" "1.162" "1.351" "1.285" "1.171" "304.6" "324.7" "320.0" "291.4" "298.0" "292.4" "354.0" "411.4" "391.5" "356.6" "" "" "" "" "" "" "" "" "" "" "244.7" "234.3" "254.2" "195.3" "206.1" "219.4" "247.9" "300.4" "391.5" "290.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794810011178551467" "False" "High" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "0.000" "False" "20.532" "34" "5" "9" "5" "118" "13.7" "8.79" "25.81" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Osteoclast signaling; Proximal tubule transport" "7" "0" "1.092" "1.094" "1.001" "0.860" "1.005" "0.933" "0.962" "0.994" "0.937" "984.8" "1075.9" "1077.0" "985.5" "846.8" "989.9" "919.1" "947.2" "979.3" "922.3" "" "" "" "" "" "" "" "" "" "" "791.0" "776.3" "855.5" "660.3" "585.7" "742.7" "643.5" "691.8" "979.3" "750.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823041984393634953" "False" "High" "IsMasterProtein" "P25774" "Cathepsin S OS=Homo sapiens OX=9606 GN=CTSS PE=1 SV=3" "0.000" "False" "20.499" "14" "4" "5" "4" "331" "37.5" "8.34" "18.10" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1520" "ENSG00000163131" "CTSS" "B4DWC9; D3DV05; hsa:1520; P25774; Q5T5I0; Q6FHS5; Q9BUG3" "Neutrophil degranulation; MHC class II antigen presentation; Degradation of the extracellular matrix; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "" "6" "0" "1.010" "1.052" "0.985" "0.939" "1.012" "0.873" "0.928" "0.959" "0.965" "589.4" "595.6" "620.0" "580.6" "553.8" "596.6" "514.7" "546.9" "565.4" "569.0" "" "" "" "" "" "" "" "" "" "" "473.4" "429.8" "492.5" "389.0" "383.0" "447.6" "360.4" "399.4" "565.4" "462.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1075701088619798442" "False" "High" "IsMasterProtein" "Q96BZ8" "Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=2" "0.000" "False" "20.487" "21" "6" "7" "6" "264" "30.5" "9.80" "22.36" "6" "" "nucleus" "" "Pf10197" "79165" "ENSG00000105617; ENSG00000275935; ENSG00000276628; ENSG00000276774; ENSG00000276959; ENSG00000277457; ENSG00000277808; ENSG00000278257; ENSG00000278426; ENSG00000278516" "LENG1" "hsa:79165; Q96BZ8; Q9HCU7" "mRNA Splicing - Major Pathway" "" "1" "0" "1.047" "1.023" "1.146" "1.096" "1.071" "0.995" "1.012" "1.005" "1.014" "708.7" "742.3" "725.2" "812.4" "776.7" "759.2" "705.3" "717.5" "712.5" "718.9" "" "" "" "" "" "" "" "" "" "" "569.2" "535.6" "576.0" "544.3" "537.2" "569.6" "493.8" "524.0" "712.5" "584.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2485392268921902957" "False" "High" "IsMasterProtein" "Q6ZN54" "Differentially expressed in FDCP 8 homolog OS=Homo sapiens OX=9606 GN=DEF8 PE=1 SV=2" "0.000" "False" "20.473" "10" "4" "5" "4" "512" "58.7" "6.52" "16.12" "4" "other biological processes" "" "other molecular function" "Pf00130, Pf13901" "54849" "ENSG00000140995" "DEF8" "B3KT65; B4DK62; B4E0S9; B7Z3H6; H3BUG7; hsa:54849; Q6ZN54; Q8N8N3; Q9NXL0" "" "" "0" "0" "1.019" "0.918" "1.007" "1.025" "0.964" "1.067" "0.925" "0.929" "0.915" "274.4" "279.6" "251.9" "276.3" "281.2" "264.5" "292.8" "253.7" "254.8" "251.1" "" "" "" "" "" "" "" "" "" "" "220.4" "201.8" "200.1" "185.1" "194.4" "198.5" "205.0" "185.3" "254.8" "204.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5741463921085592561" "False" "High" "IsMasterProtein" "O75962" "Triple functional domain protein OS=Homo sapiens OX=9606 GN=TRIO PE=1 SV=2" "0.000" "False" "20.447" "1" "4" "4" "4" "3097" "346.7" "6.37" "15.80" "4" "cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00018, Pf00069, Pf00169, Pf00435, Pf00621, Pf07679, Pf13716, Pf16609" "7204" "ENSG00000038382" "TRIO" "D3DTD1; hsa:7204; O75962; Q13458; Q59EQ7; Q6PJC9; Q6ZN05; Q8IWK8" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling" "Microtubule cytoskeleton regulation; Neural crest cell migration during development; Neural crest cell migration in cancer; GNAQ pathways in port-wine stain" "15" "0" "0.934" "0.954" "1.122" "1.080" "0.979" "1.046" "0.950" "0.911" "0.924" "133.8" "125.0" "127.7" "150.2" "144.5" "130.9" "140.0" "127.1" "121.9" "123.6" "" "" "" "" "" "" "" "" "" "" "107.5" "90.2" "101.4" "100.6" "99.9" "98.2" "98.0" "92.8" "121.9" "100.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-939904416920954895" "False" "High" "IsMasterProtein" "O95271" "Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=2" "0.000" "False" "20.446" "4" "5" "7" "5" "1327" "142.0" "7.05" "22.85" "5" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00023, Pf00644, Pf07647, Pf13637, Pf13857" "8658" "ENSG00000173273; ENSG00000285372" "TNKS" "hsa:8658; O95271; O95272; Q4G0F2; Q59FX0" "Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN" "NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds; 8p23.1 copy number variation syndrome" "8" "0" "1.012" "1.004" "0.920" "1.019" "0.969" "1.033" "0.911" "0.892" "1.023" "85.4" "86.5" "85.8" "78.6" "87.1" "82.7" "88.2" "77.8" "76.2" "87.4" "" "" "" "" "" "" "" "" "" "" "68.6" "62.4" "68.1" "52.6" "60.2" "62.1" "61.8" "56.8" "76.2" "71.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302627442796740728" "False" "High" "IsMasterProtein" "Q15771" "Ras-related protein Rab-30 OS=Homo sapiens OX=9606 GN=RAB30 PE=1 SV=2" "0.000" "False" "20.441" "18" "3" "6" "2" "203" "23.0" "4.97" "23.15" "3" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "27314" "ENSG00000137502" "RAB30" "hsa:27314; Q15771; Q6FGK1; Q6MZH2; Q96CI8" "Intra-Golgi traffic; RAB geranylgeranylation" "" "2" "0" "0.831" "0.890" "1.013" "0.923" "0.801" "0.967" "0.894" "0.761" "1.072" "21.1" "17.6" "18.8" "21.4" "19.5" "16.9" "20.4" "18.9" "16.1" "22.6" "" "" "" "" "" "" "" "" "" "" "17.0" "12.7" "14.9" "14.3" "13.5" "12.7" "14.3" "13.8" "16.1" "18.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849242953917426165" "False" "High" "IsMasterProtein" "Q9HCD5" "Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2" "0.000" "False" "20.434" "11" "6" "6" "6" "579" "65.5" "9.60" "16.49" "6" "signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "" "57727" "ENSG00000124160" "NCOA5" "B2RTV9; E1P5R0; Q6HA99; Q9H1F2; Q9H2T2; Q9H4Y9; Q9HCD5" "" "" "0" "0" "0.938" "0.934" "1.000" "1.084" "1.015" "1.169" "1.049" "1.035" "0.999" "409.0" "383.7" "382.2" "409.2" "443.4" "415.2" "478.3" "429.0" "423.2" "408.5" "" "" "" "" "" "" "" "" "" "" "328.5" "276.9" "303.6" "274.2" "306.7" "311.5" "334.9" "313.3" "423.2" "332.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108263305464485910" "False" "High" "IsMasterProtein" "O95644" "Nuclear factor of activated T-cells, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=NFATC1 PE=1 SV=3" "0.000" "False" "20.409" "5" "5" "5" "4" "943" "101.2" "6.99" "15.57" "5" "stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4772" "ENSG00000131196" "NFATC1" "B5B2M4; B5B2M5; B5B2M6; B5B2M7; B5B2M8; B5B2M9; B5B2N1; hsa:4772; O95644; Q12865; Q15793; Q2M1S3" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "Heart development; RANKL/RANK signaling pathway; Ectoderm differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Wnt signaling; Vitamin D in inflammatory diseases; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; Th17 cell differentiation pathway; DYRK1A involvement regarding cell proliferation in brain development; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; IL-26 signaling pathways; T-cell receptor signaling pathway" "20" "0" "0.915" "1.065" "1.069" "1.015" "1.052" "0.952" "1.010" "1.044" "1.052" "191.8" "175.6" "204.4" "205.1" "194.8" "201.7" "182.7" "193.7" "200.3" "201.8" "" "" "" "" "" "" "" "" "" "" "154.1" "126.7" "162.3" "137.4" "134.7" "151.4" "127.9" "141.4" "200.3" "164.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-443661170883717287" "False" "High" "IsMasterProtein" "Q9NQ92" "Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3" "0.000" "False" "20.404" "22" "3" "4" "3" "184" "20.1" "4.18" "13.71" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf15340" "55352" "ENSG00000172301" "COPRS" "A6NP14; E1P656; hsa:55352; Q96EF5; Q96P75; Q9NQ92" "RMTs methylate histone arginines" "NF1 copy number variation syndrome" "2" "0" "1.158" "1.065" "1.074" "0.965" "1.042" "0.951" "1.072" "1.173" "1.062" "228.1" "264.2" "242.9" "244.9" "220.1" "237.7" "217.0" "244.4" "267.6" "242.3" "" "" "" "" "" "" "" "" "" "" "183.2" "190.6" "192.9" "164.1" "152.2" "178.3" "151.9" "178.5" "267.6" "197.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957461368778197343" "False" "High" "IsMasterProtein" "Q96I51" "RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=3" "0.000" "False" "20.395" "11" "3" "4" "3" "464" "49.9" "8.29" "13.96" "3" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415, Pf13540" "81554" "ENSG00000274523" "RCC1L" "D3DXK0; F5GX55; F5H6C7; hsa:81554; Q548B1; Q8IW88; Q8N572; Q96I51; Q9H0G7" "" "" "0" "0" "1.261" "1.064" "1.108" "1.170" "1.121" "1.090" "0.954" "0.971" "1.040" "132.9" "167.6" "141.4" "147.2" "155.5" "148.9" "144.8" "126.8" "129.0" "138.2" "" "" "" "" "" "" "" "" "" "" "106.7" "120.9" "112.3" "98.6" "107.5" "111.7" "101.4" "92.6" "129.0" "112.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3995888645862527253" "False" "High" "IsMasterProtein" "A4D1E9" "GTP-binding protein 10 OS=Homo sapiens OX=9606 GN=GTPBP10 PE=1 SV=1" "0.000" "False" "20.392" "13" "4" "4" "4" "387" "42.9" "9.03" "11.43" "4" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01018, Pf01926" "85865" "ENSG00000105793" "GTPBP10" "A4D1E9; B4DFY6; hsa:85865; Q3B7A6; Q5H9V2; Q8IXG8; Q8N982; Q8WU16; Q9BSP1; Q9Y6T6" "" "" "0" "0" "0.939" "0.904" "1.150" "1.039" "1.057" "0.933" "1.087" "1.031" "0.954" "244.9" "229.9" "221.4" "281.6" "254.5" "258.8" "228.5" "266.3" "252.5" "233.6" "" "" "" "" "" "" "" "" "" "" "196.7" "165.9" "175.8" "188.7" "176.0" "194.2" "160.0" "194.5" "252.5" "190.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2602489287625283403" "False" "High" "IsMasterProtein" "P62330" "ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2" "0.000" "False" "20.387" "22" "2" "2" "2" "175" "20.1" "8.95" "12.84" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00025" "382" "ENSG00000165527" "ARF6" "hsa:382; P26438; P62330; Q6FGZ2" "Clathrin-mediated endocytosis; TBC/RABGAPs; MET receptor recycling" "VEGFA-VEGFR2 signaling; Ras signaling; EGF/EGFR signaling pathway; IL-18 signaling pathway; Insulin signaling; CCL18 signaling pathway; 2q13 copy number variation syndrome" "10" "0" "0.972" "1.086" "0.932" "0.994" "1.013" "1.029" "1.061" "1.062" "0.943" "168.1" "163.5" "182.6" "156.6" "167.2" "170.4" "172.9" "178.3" "178.6" "158.5" "" "" "" "" "" "" "" "" "" "" "135.0" "118.0" "145.1" "104.9" "115.6" "127.8" "121.1" "130.2" "178.6" "128.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2326437507521645462" "False" "High" "IsMasterProtein" "Q9P2W1" "Homologous-pairing protein 2 homolog OS=Homo sapiens OX=9606 GN=PSMC3IP PE=1 SV=1" "0.000" "False" "20.386" "19" "3" "4" "3" "217" "24.9" "7.81" "16.18" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07106, Pf18517" "29893" "ENSG00000131470" "PSMC3IP" "C5ILB7; hsa:29893; Q14458; Q8WXG2; Q96HA2; Q9P2W1" "Meiotic recombination" "Androgen receptor signaling pathway; Primary ovarian insufficiency" "3" "0" "0.930" "1.102" "1.149" "1.062" "1.123" "1.099" "1.247" "1.175" "1.145" "106.0" "98.6" "116.9" "121.8" "112.6" "119.1" "116.5" "132.2" "124.6" "121.4" "" "" "" "" "" "" "" "" "" "" "85.2" "71.2" "92.9" "81.6" "77.9" "89.3" "81.6" "96.6" "124.6" "98.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6950244637905263726" "False" "High" "IsMasterProtein" "Q9Y3B4" "Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1" "0.000" "False" "20.383" "39" "4" "8" "4" "125" "14.6" "9.38" "24.55" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00076" "51639" "ENSG00000115128" "SF3B6" "hsa:51639; Q53TM1; Q9Y3B4" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "0.981" "1.067" "0.929" "0.872" "0.948" "0.872" "0.943" "1.026" "1.012" "496.3" "487.1" "529.8" "461.1" "432.6" "470.5" "432.7" "468.1" "509.1" "502.4" "" "" "" "" "" "" "" "" "" "" "398.7" "351.5" "420.9" "308.9" "299.2" "353.0" "302.9" "341.8" "509.1" "408.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480687027944615342" "False" "High" "IsMasterProtein" "Q8NHG8" "E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1" "0.000" "False" "20.374" "17" "3" "3" "3" "242" "24.1" "7.09" "11.97" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13639" "223082" "ENSG00000180233" "ZNRF2" "Q8NHG8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.034" "1.031" "1.000" "1.059" "0.963" "1.056" "1.024" "0.954" "1.060" "133.1" "137.7" "137.3" "133.2" "141.0" "128.2" "140.6" "136.3" "127.1" "141.1" "" "" "" "" "" "" "" "" "" "" "106.9" "99.3" "109.0" "89.2" "97.5" "96.2" "98.4" "99.6" "127.1" "114.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8357851412820186252" "False" "High" "IsMasterProtein" "O60675" "Transcription factor MafK OS=Homo sapiens OX=9606 GN=MAFK PE=1 SV=1" "0.000" "False" "20.362" "37" "5" "7" "2" "156" "17.5" "10.10" "18.97" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03131" "7975" "ENSG00000198517" "MAFK" "A4D214; hsa:7975; O60675" "Heme signaling; Factors involved in megakaryocyte development and platelet production; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression" "Quercetin and Nf-kB / AP-1 induced apoptosis; Ethanol metabolism production of ROS by CYP2E1" "13" "0" "0.895" "0.743" "1.015" "0.775" "0.758" "1.015" "0.847" "0.898" "1.104" "30.4" "27.2" "22.6" "30.9" "23.6" "23.1" "30.9" "25.8" "27.3" "33.6" "" "" "" "" "" "" "" "" "" "" "24.4" "19.6" "18.0" "20.7" "16.3" "17.3" "21.6" "18.8" "27.3" "27.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5096502141000675032" "False" "High" "IsMasterProtein" "Q8TBB5" "Kelch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KLHDC4 PE=1 SV=1" "0.000" "False" "20.337" "9" "3" "3" "3" "520" "57.9" "5.72" "11.41" "3" "" "" "" "Pf13415, Pf13418" "54758" "ENSG00000104731" "KLHDC4" "D3DUN3; D3DUN4; D3DUN5; hsa:54758; Q8TBB5; Q96F29; Q9BVN3" "" "" "0" "0" "1.157" "1.045" "1.114" "1.031" "1.031" "1.006" "0.869" "1.027" "1.100" "238.8" "276.4" "249.4" "266.0" "246.1" "246.2" "240.2" "207.5" "245.3" "262.6" "" "" "" "" "" "" "" "" "" "" "191.8" "199.4" "198.1" "178.2" "170.2" "184.7" "168.2" "151.5" "245.3" "213.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518403686067478951" "False" "High" "IsMasterProtein" "O95149" "Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1" "0.000" "False" "20.331" "16" "5" "9" "5" "360" "41.1" "6.64" "27.47" "5" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11538" "10073" "ENSG00000169371" "SNUPN" "A6NE34; A8K0B0; D3DW76; hsa:10073; O95149" "snRNP Assembly" "" "1" "0" "1.018" "1.005" "0.927" "0.870" "0.966" "0.822" "0.886" "0.853" "0.957" "1281.9" "1305.6" "1288.5" "1188.6" "1115.8" "1238.4" "1054.3" "1135.7" "1093.6" "1226.5" "" "" "" "" "" "" "" "" "" "" "1029.6" "942.1" "1023.5" "796.4" "771.7" "929.1" "738.2" "829.4" "1093.6" "997.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877552904475964910" "False" "High" "IsMasterProtein" "Q9NX63" "MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1" "0.000" "False" "20.317" "22" "5" "5" "5" "227" "26.1" "8.28" "16.21" "5" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf05300" "54927" "ENSG00000106554" "CHCHD3" "hsa:54927; Q9NX63" "Cristae formation; Mitochondrial protein import" "" "2" "0" "1.064" "0.902" "1.141" "1.084" "0.983" "1.129" "1.018" "1.100" "1.052" "149.1" "158.6" "134.5" "170.1" "161.6" "146.5" "168.4" "151.7" "164.0" "156.9" "" "" "" "" "" "" "" "" "" "" "119.7" "114.5" "106.9" "114.0" "111.8" "109.9" "117.9" "110.8" "164.0" "127.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842001087563209976" "False" "High" "IsMasterProtein" "Q9NVN8" "Guanine nucleotide-binding protein-like 3-like protein OS=Homo sapiens OX=9606 GN=GNL3L PE=1 SV=1" "0.000" "False" "20.309" "10" "4" "4" "4" "582" "65.5" "8.44" "11.79" "4" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf01926" "54552" "ENSG00000130119" "GNL3L" "hsa:54552; Q9NVN8" "" "" "0" "0" "0.913" "0.956" "1.188" "0.954" "0.963" "0.874" "0.775" "0.830" "1.115" "65.9" "60.1" "63.0" "78.3" "62.9" "63.4" "57.6" "51.1" "54.7" "73.5" "" "" "" "" "" "" "" "" "" "" "52.9" "43.4" "50.0" "52.4" "43.5" "47.6" "40.3" "37.3" "54.7" "59.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5970441865792546005" "False" "High" "IsMasterProtein" "P04920" "Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4" "0.000" "False" "20.307" "6" "6" "6" "6" "1241" "136.9" "6.29" "17.80" "6" "transport;developmental processes;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00955, Pf07565" "6522" "ENSG00000164889" "SLC4A2" "B2R6T0; B4DIT0; D3DX05; F8W682; hsa:6522; P04920; Q45EY5; Q969L3" "Bicarbonate transporters" "Proximal tubule transport" "2" "0" "1.016" "1.028" "1.191" "0.963" "1.053" "1.177" "1.151" "1.223" "1.086" "247.8" "251.8" "254.7" "295.2" "238.5" "260.8" "291.6" "285.2" "303.0" "269.0" "" "" "" "" "" "" "" "" "" "" "199.0" "181.7" "202.3" "197.8" "165.0" "195.7" "204.2" "208.3" "303.0" "218.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6138498598484703965" "False" "High" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "0.000" "False" "20.273" "26" "8" "13" "6" "207" "22.0" "9.38" "36.81" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "2" "0" "0.987" "1.011" "0.955" "0.935" "0.989" "0.915" "0.954" "0.996" "0.988" "1423.0" "1404.8" "1437.9" "1359.6" "1329.8" "1407.0" "1302.4" "1357.6" "1417.5" "1406.4" "" "" "" "" "" "" "" "" "" "" "1142.9" "1013.7" "1142.2" "910.9" "919.7" "1055.7" "911.9" "991.4" "1417.5" "1143.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8122664404387137367" "False" "High" "IsMasterProtein" "Q96JP5" "E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1" "0.000" "False" "20.273" "9" "4" "4" "4" "570" "63.4" "7.36" "15.79" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00096" "80829" "ENSG00000186660" "ZFP91" "A6NHC4; A8MSG7; Q86V47; Q96JP4; Q96JP5; Q96QA3" "" "" "0" "0" "1.006" "1.123" "1.005" "1.098" "1.060" "1.029" "1.123" "1.055" "1.004" "301.8" "303.6" "339.0" "303.2" "331.5" "320.0" "310.6" "339.0" "318.3" "302.9" "" "" "" "" "" "" "" "" "" "" "242.4" "219.0" "269.3" "203.2" "229.3" "240.1" "217.5" "247.6" "318.3" "246.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8785162228829611300" "False" "High" "IsMasterProtein" "Q38SD2" "Leucine-rich repeat serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=LRRK1 PE=1 SV=3" "0.000" "False" "20.230" "3" "6" "6" "6" "2015" "225.2" "6.68" "15.38" "6" "other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00069, Pf00560, Pf08477, Pf16095" "79705" "ENSG00000154237" "LRRK1" "Q38SD2; Q6NVH5; Q6NYC0; Q6ZNL9; Q6ZNM9; Q96JN5; Q9H5S3" "" "" "0" "0" "0.915" "0.949" "0.890" "1.002" "1.101" "0.738" "0.793" "0.967" "1.019" "181.3" "165.8" "172.0" "161.4" "181.6" "199.7" "133.8" "143.7" "175.4" "184.7" "" "" "" "" "" "" "" "" "" "" "145.6" "119.7" "136.6" "108.1" "125.6" "149.8" "93.7" "105.0" "175.4" "150.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256135523585103311" "False" "High" "IsMasterProtein" "Q86XL3" "Ankyrin repeat and LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKLE2 PE=1 SV=4" "0.000" "False" "20.194" "6" "6" "6" "6" "938" "104.1" "7.09" "15.98" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00023, Pf01693, Pf03020" "23141" "ENSG00000176915" "ANKLE2" "A8KAG3; B3KN97; B3KSF8; hsa:23141; O75176; Q6P6A5; Q86XL3; Q8TAZ9; Q96DH4" "RAC2 GTPase cycle; RHOG GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation" "" "3" "0" "1.137" "0.951" "0.985" "1.111" "0.876" "1.004" "0.936" "0.921" "1.015" "302.9" "344.3" "288.1" "298.3" "336.5" "265.2" "304.1" "283.4" "278.9" "307.4" "" "" "" "" "" "" "" "" "" "" "243.3" "248.4" "228.8" "199.9" "232.7" "199.0" "212.9" "206.9" "278.9" "250.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-255680334974208161" "False" "High" "IsMasterProtein" "Q9Y4K4" "Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=3" "0.000" "False" "20.170" "7" "4" "5" "4" "846" "95.0" "7.72" "15.61" "4" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00069, Pf00780" "11183" "ENSG00000012983" "MAP4K5" "A0A804HIS2; hsa:11183" "" "Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Insulin signaling" "3" "0" "1.071" "1.030" "1.082" "1.039" "1.092" "1.111" "1.055" "1.084" "1.045" "409.7" "439.0" "422.0" "443.3" "425.7" "447.2" "455.1" "432.4" "444.1" "427.9" "" "" "" "" "" "" "" "" "" "" "329.1" "316.8" "335.2" "297.0" "294.4" "335.6" "318.7" "315.8" "444.1" "348.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2427980612750648457" "False" "High" "IsMasterProtein" "P21359" "Neurofibromin OS=Homo sapiens OX=9606 GN=NF1 PE=1 SV=2" "0.000" "False" "20.168" "2" "6" "7" "6" "2839" "319.2" "7.39" "19.74" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf13716" "4763" "ENSG00000196712" "NF1" "hsa:4763; O00662; P21359; Q14284; Q14930; Q14931; Q9UMK3" "Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants" "Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance; NF1 copy number variation syndrome" "14" "0" "0.980" "0.938" "0.981" "1.053" "1.052" "0.969" "1.005" "1.028" "1.037" "671.1" "657.8" "629.2" "658.1" "706.6" "706.1" "650.2" "674.7" "689.6" "695.7" "" "" "" "" "" "" "" "" "" "" "539.1" "474.7" "499.8" "440.9" "488.7" "529.8" "455.2" "492.7" "689.6" "565.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3306595998206250770" "False" "High" "IsMasterProtein" "P62753" "Small ribosomal subunit protein eS6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "0.000" "False" "20.160" "19" "4" "6" "4" "249" "28.7" "10.84" "16.21" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1 modulates host translation machinery" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "49" "0" "1.085" "1.143" "1.164" "1.173" "1.048" "1.451" "1.091" "1.219" "1.271" "63.2" "68.6" "72.3" "73.6" "74.2" "66.3" "91.8" "69.0" "77.1" "80.4" "" "" "" "" "" "" "" "" "" "" "50.8" "49.5" "57.4" "49.3" "51.3" "49.7" "64.2" "50.4" "77.1" "65.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1641780535886565556" "False" "High" "IsMasterProtein" "Q7L1T6" "Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1" "0.000" "False" "20.157" "13" "6" "7" "6" "521" "59.4" "7.72" "20.68" "6" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00173, Pf00175, Pf00970, Pf04969" "51167" "ENSG00000065615" "CYB5R4" "B1AEM2; hsa:51167; Q5TGI9; Q7L1T6; Q9NUE4; Q9UHI9" "Erythrocytes take up carbon dioxide and release oxygen" "Oxidation by cytochrome P450" "2" "0" "1.029" "0.978" "0.984" "1.038" "0.973" "1.027" "0.960" "0.989" "1.013" "638.8" "657.2" "625.0" "628.6" "663.2" "621.4" "656.2" "613.6" "631.9" "647.2" "" "" "" "" "" "" "" "" "" "" "513.1" "474.2" "496.4" "421.2" "458.7" "466.2" "459.5" "448.1" "631.9" "526.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2210481861453836415" "False" "High" "IsMasterProtein" "Q9BVM2" "Protein DPCD OS=Homo sapiens OX=9606 GN=DPCD PE=1 SV=2" "0.000" "False" "20.155" "19" "4" "5" "4" "203" "23.2" "9.03" "16.69" "4" "transport;developmental processes;other biological processes" "non-structural extracellular" "" "Pf14913" "25911" "ENSG00000166171" "DPCD" "A8K289; hsa:25911; Q6QNL3; Q8N5R1; Q9BVM2; Q9UFY6" "" "" "0" "0" "1.055" "0.957" "1.014" "0.979" "0.916" "0.918" "0.961" "0.941" "0.939" "555.4" "585.8" "531.8" "563.1" "543.7" "509.0" "509.7" "534.0" "522.6" "521.5" "" "" "" "" "" "" "" "" "" "" "446.1" "422.7" "422.4" "377.3" "376.0" "381.9" "356.9" "390.0" "522.6" "424.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901597498303011274" "False" "High" "IsMasterProtein" "P14621" "Acylphosphatase-2 OS=Homo sapiens OX=9606 GN=ACYP2 PE=1 SV=2" "0.000" "False" "20.142" "29" "3" "5" "3" "99" "11.1" "9.50" "16.69" "3" "other metabolic processes" "" "other molecular function" "Pf00708" "98" "ENSG00000170634" "ACYP2" "hsa:98; P14621" "" "" "0" "0" "0.944" "0.956" "1.023" "0.957" "0.967" "0.950" "0.917" "0.983" "1.005" "369.6" "348.8" "353.5" "378.0" "353.9" "357.4" "351.3" "339.0" "363.3" "371.5" "" "" "" "" "" "" "" "" "" "" "296.9" "251.7" "280.8" "253.2" "244.8" "268.2" "246.0" "247.6" "363.3" "302.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-822484129541956869" "False" "High" "IsMasterProtein" "Q14149" "MORC family CW-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=MORC3 PE=1 SV=3" "0.000" "False" "20.138" "6" "6" "6" "5" "939" "107.0" "5.60" "19.31" "6" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07496, Pf13589, Pf17942" "23515" "ENSG00000159256" "MORC3" "A8KA92; hsa:23515; Q14149; Q9UEZ2" "" "Interactome of polycomb repressive complex 2 (PRC2)" "1" "0" "1.003" "0.929" "0.964" "0.964" "0.990" "1.018" "0.915" "0.925" "1.064" "468.0" "469.6" "434.7" "451.2" "451.1" "463.3" "476.3" "428.0" "433.0" "498.2" "" "" "" "" "" "" "" "" "" "" "375.9" "338.9" "345.3" "302.3" "312.0" "347.6" "333.5" "312.6" "433.0" "405.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6698557715673705148" "False" "High" "IsMasterProtein" "Q6P3W7" "SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1" "0.000" "False" "20.137" "5" "4" "4" "4" "929" "103.6" "8.22" "13.87" "4" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "55681" "ENSG00000136021" "SCYL2" "A8KAB5; hsa:55681; Q6P3W7; Q96EF4; Q96ST4; Q9H7V5; Q9NVH3; Q9P2I7" "" "" "0" "0" "1.022" "0.908" "1.050" "0.990" "1.003" "0.950" "1.068" "1.095" "1.068" "592.3" "605.1" "538.1" "621.6" "586.2" "594.0" "562.5" "632.7" "648.4" "632.5" "" "" "" "" "" "" "" "" "" "" "475.7" "436.7" "427.4" "416.5" "405.4" "445.6" "393.8" "462.1" "648.4" "514.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4154792399073788951" "False" "High" "IsMasterProtein" "Q13541" "Eukaryotic translation initiation factor 4E-binding protein 1 OS=Homo sapiens OX=9606 GN=EIF4EBP1 PE=1 SV=3" "0.000" "False" "20.135" "32" "2" "6" "2" "118" "12.6" "5.48" "18.78" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05456" "1978" "ENSG00000187840" "EIF4EBP1" "B2R502; D3DSW8; hsa:1978; Q13541; Q6IBN3" "mTORC1-mediated signalling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" "Translation factors; AMP-activated protein kinase signaling; Target of rapamycin signaling; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; RAC1/PAK1/p38/MMP2 pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Hypertrophy model; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway" "32" "0" "1.009" "1.010" "1.082" "1.084" "1.109" "0.975" "1.042" "1.047" "1.097" "396.7" "400.3" "400.6" "429.2" "430.1" "440.1" "386.6" "413.4" "415.5" "435.2" "" "" "" "" "" "" "" "" "" "" "318.6" "288.8" "318.2" "287.5" "297.5" "330.2" "270.7" "301.9" "415.5" "353.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848338417616042821" "False" "High" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "0.000" "False" "20.133" "23" "5" "7" "5" "261" "28.0" "8.05" "21.48" "5" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "" "2" "0" "1.073" "0.997" "1.144" "1.079" "1.044" "1.043" "1.043" "1.059" "1.017" "393.2" "421.9" "391.9" "449.9" "424.3" "410.7" "410.0" "410.0" "416.5" "400.0" "" "" "" "" "" "" "" "" "" "" "315.8" "304.5" "311.3" "301.5" "293.5" "308.1" "287.1" "299.4" "416.5" "325.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8485687817967320227" "False" "High" "IsMasterProtein" "Q96ES7" "SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1" "0.000" "False" "20.107" "11" "3" "3" "3" "293" "33.2" "8.10" "13.63" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07039" "112869" "ENSG00000176476" "SGF29" "hsa:112869; Q96ES7; Q96MF5" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "1.000" "0.999" "0.969" "0.985" "0.996" "0.901" "0.974" "0.940" "0.989" "546.5" "546.4" "546.0" "529.8" "538.3" "544.4" "492.5" "532.5" "513.5" "540.6" "" "" "" "" "" "" "" "" "" "" "439.0" "394.3" "433.7" "355.0" "372.3" "408.5" "344.8" "388.9" "513.5" "439.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311185762453524816" "False" "High" "IsMasterProtein" "O95905" "Protein ecdysoneless homolog OS=Homo sapiens OX=9606 GN=ECD PE=1 SV=1" "0.000" "False" "20.095" "7" "5" "6" "5" "644" "72.7" "4.87" "14.52" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07093" "11319" "ENSG00000122882" "ECD" "C9JX46; E9PAW8; hsa:11319; O95905" "" "" "0" "0" "1.001" "0.945" "1.048" "0.938" "1.022" "1.004" "1.057" "0.996" "1.016" "367.5" "367.8" "347.2" "385.1" "344.6" "375.6" "369.0" "388.4" "366.1" "373.4" "" "" "" "" "" "" "" "" "" "" "295.2" "265.4" "275.8" "258.0" "238.3" "281.8" "258.4" "283.6" "366.1" "303.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6008736440558391918" "False" "High" "IsMasterProtein" "O75157" "TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3" "0.000" "False" "20.080" "6" "5" "9" "3" "780" "79.2" "5.02" "22.39" "5" "stress response;other biological processes" "" "" "Pf01166" "9819" "ENSG00000196428" "TSC22D2" "D3DNI5; hsa:9819; O75157; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8" "" "" "0" "0" "1.004" "1.043" "1.054" "0.893" "0.926" "0.990" "0.976" "0.994" "0.983" "361.2" "362.6" "376.6" "380.6" "322.8" "334.3" "357.8" "352.5" "359.0" "355.0" "" "" "" "" "" "" "" "" "" "" "290.2" "261.6" "299.2" "255.0" "223.2" "250.8" "250.5" "257.4" "359.0" "288.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6685402705848511390" "False" "High" "IsMasterProtein" "Q92820" "Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2" "0.000" "False" "20.079" "13" "4" "5" "4" "318" "35.9" "7.11" "17.78" "4" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00117, Pf07722" "8836" "ENSG00000137563" "GGH" "hsa:8836; Q92820" "Neutrophil degranulation" "Fluoropyrimidine activity" "2" "0" "1.055" "1.074" "1.014" "1.044" "1.083" "1.029" "1.066" "1.045" "1.062" "515.8" "544.4" "554.0" "523.0" "538.7" "558.4" "531.0" "549.8" "539.0" "547.6" "" "" "" "" "" "" "" "" "" "" "414.3" "392.8" "440.1" "350.4" "372.6" "419.0" "371.8" "401.5" "539.0" "445.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4340156669496060526" "False" "High" "IsMasterProtein" "Q9Y3C6" "Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1" "0.000" "False" "20.072" "40" "6" "10" "6" "166" "18.2" "7.99" "21.81" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "other molecular function" "Pf00160" "51645" "ENSG00000137168" "PPIL1" "hsa:51645; O15001; Q5TDC9; Q9Y3C6" "mRNA Splicing - Major Pathway" "" "1" "0" "0.996" "0.909" "0.985" "1.027" "0.917" "1.030" "1.016" "0.967" "0.999" "752.7" "749.4" "684.0" "741.8" "772.8" "690.5" "775.3" "764.5" "728.0" "752.0" "" "" "" "" "" "" "" "" "" "" "604.6" "540.7" "543.3" "497.0" "534.4" "518.1" "542.9" "558.3" "728.0" "611.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3937524236337839102" "False" "High" "IsMasterProtein" "P32121" "Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2" "0.000" "False" "20.054" "13" "5" "5" "5" "409" "46.1" "7.69" "13.95" "5" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00339, Pf02752" "409" "ENSG00000141480" "ARRB2" "B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688; hsa:409; P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6" "G alpha (s) signalling events; Ub-specific processing proteases; Activation of SMO; Activated NOTCH1 Transmits Signal to the Nucleus; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Corticotropin-releasing hormone signaling pathway; Complement system; Myometrial relaxation and contraction pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells" "27" "0" "0.925" "0.940" "0.954" "1.008" "0.957" "0.926" "0.897" "0.867" "0.898" "366.1" "338.7" "344.1" "349.3" "369.0" "350.3" "339.0" "328.6" "317.5" "328.6" "" "" "" "" "" "" "" "" "" "" "294.1" "244.4" "273.3" "234.1" "255.2" "262.8" "237.4" "240.0" "317.5" "267.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8834965082719872925" "False" "High" "IsMasterProtein" "Q96EQ0" "Small glutamine-rich tetratricopeptide repeat-containing protein beta OS=Homo sapiens OX=9606 GN=SGTB PE=1 SV=1" "0.000" "False" "20.049" "13" "4" "7" "4" "304" "33.4" "4.92" "20.65" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytosol" "other molecular function" "Pf00515, Pf13414, Pf16546" "54557" "ENSG00000197860" "SGTB" "hsa:54557; Q96EQ0" "" "" "0" "0" "0.958" "1.058" "0.971" "0.942" "1.035" "0.949" "1.009" "1.058" "1.078" "583.2" "558.7" "616.8" "566.4" "549.3" "603.6" "553.8" "588.7" "617.3" "628.9" "" "" "" "" "" "" "" "" "" "" "468.4" "403.2" "490.0" "379.5" "379.9" "452.9" "387.7" "429.9" "617.3" "511.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342560622817440014" "False" "High" "IsMasterProtein" "Q96PU8" "KH domain-containing RNA-binding protein QKI OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1" "0.000" "False" "20.032" "14" "4" "6" "4" "341" "37.6" "8.56" "18.44" "4" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16544, Pf16551" "9444" "ENSG00000112531" "QKI" "hsa:9444; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q96PU8; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1" "Signaling by BRAF and RAF1 fusions" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "3" "0" "0.983" "0.954" "0.931" "0.965" "0.977" "0.957" "0.999" "1.011" "0.925" "608.5" "598.0" "580.8" "566.7" "587.5" "594.8" "582.1" "608.1" "615.2" "562.6" "" "" "" "" "" "" "" "" "" "" "488.8" "431.5" "461.3" "379.7" "406.3" "446.2" "407.6" "444.1" "615.2" "457.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7560300285237323007" "False" "High" "IsMasterProtein" "Q12980" "GATOR1 complex protein NPRL3 OS=Homo sapiens OX=9606 GN=NPRL3 PE=1 SV=1" "0.000" "False" "20.012" "12" "5" "5" "5" "569" "63.6" "6.98" "13.91" "5" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf03666" "8131" "ENSG00000103148" "NPRL3" "D3DU40; hsa:8131; Q12980; Q1W6H0; Q4TT56; Q92469" "Amino acids regulate mTORC1" "22q11.2 copy number variation syndrome" "2" "0" "0.977" "0.974" "1.124" "1.080" "1.057" "1.039" "0.942" "0.964" "1.259" "107.4" "104.9" "104.6" "120.8" "116.0" "113.6" "111.6" "101.2" "103.6" "135.3" "" "" "" "" "" "" "" "" "" "" "86.3" "75.7" "83.1" "80.9" "80.2" "85.2" "78.1" "73.9" "103.6" "110.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3838187860165332500" "False" "High" "IsMasterProtein" "P52564" "Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1" "0.000" "False" "19.971" "14" "5" "7" "1" "334" "37.5" "7.39" "20.84" "5" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5608" "ENSG00000108984" "MAP2K6" "hsa:5608; P52564" "Oxidative Stress Induced Senescence; Interleukin-1 signaling; PKR-mediated signaling; Myogenesis; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; PI5P Regulates TP53 Acetylation" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "41" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7333138879338488080" "False" "High" "IsMasterProtein" "Q9GZM8" "Nuclear distribution protein nudE-like 1 OS=Homo sapiens OX=9606 GN=NDEL1 PE=1 SV=1" "0.000" "False" "19.938" "11" "3" "4" "2" "345" "38.4" "5.24" "17.09" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "81565" "ENSG00000166579" "NDEL1" "B3KP93; D3DTS0; hsa:81565; J3QT32; Q86T80; Q8TAR7; Q9GZM8; Q9UH50" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "8" "0" "0.964" "0.927" "1.054" "0.953" "0.997" "1.019" "0.959" "0.987" "1.056" "296.7" "286.0" "275.0" "312.8" "282.9" "295.9" "302.3" "284.5" "292.8" "313.2" "" "" "" "" "" "" "" "" "" "" "238.3" "206.4" "218.5" "209.6" "195.6" "222.0" "211.6" "207.8" "292.8" "254.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3091495107374211726" "False" "High" "IsMasterProtein" "Q9H501" "ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1" "0.000" "False" "19.929" "5" "3" "3" "3" "851" "98.7" "5.11" "12.44" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf08159" "51575" "ENSG00000089048" "ESF1" "hsa:51575; Q86X92; Q9H501; Q9H9Q5; Q9HA35; Q9NX93; Q9P1S6" "" "" "0" "0" "1.010" "1.002" "0.942" "0.971" "1.005" "0.990" "1.052" "1.056" "1.056" "308.1" "311.2" "308.8" "290.3" "299.1" "309.7" "305.1" "324.1" "325.3" "325.3" "" "" "" "" "" "" "" "" "" "" "247.5" "224.5" "245.3" "194.5" "206.8" "232.4" "213.6" "236.7" "325.3" "264.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479844659917987073" "False" "High" "IsMasterProtein" "Q9NQ48" "Leucine zipper transcription factor-like protein 1 OS=Homo sapiens OX=9606 GN=LZTFL1 PE=1 SV=1" "0.000" "False" "19.915" "11" "3" "4" "3" "299" "34.6" "5.36" "10.30" "3" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15294" "54585" "ENSG00000163818" "LZTFL1" "B3KSI9; B4E0K7; hsa:54585; Q8TC61; Q9NQ48; Q9NQ56" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "5" "0" "1.046" "0.982" "1.023" "1.078" "1.006" "0.888" "0.868" "0.964" "0.988" "234.6" "245.3" "230.5" "240.0" "252.9" "236.0" "208.3" "203.8" "226.2" "231.8" "" "" "" "" "" "" "" "" "" "" "188.5" "177.0" "183.1" "160.8" "174.9" "177.1" "145.8" "148.8" "226.2" "188.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190260410723795831" "False" "High" "IsMasterProtein" "Q14257" "Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1" "0.000" "False" "19.914" "18" "4" "4" "4" "317" "36.9" "4.40" "13.24" "4" "" "ER/Golgi;nucleus" "other molecular function" "Pf13202, Pf13499" "5955" "ENSG00000117906" "RCN2" "A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8" "" "" "0" "0" "1.060" "0.831" "0.957" "0.922" "0.941" "0.989" "1.012" "0.950" "0.969" "205.7" "218.1" "170.9" "196.9" "189.6" "193.5" "203.5" "208.2" "195.3" "199.3" "" "" "" "" "" "" "" "" "" "" "165.2" "157.4" "135.7" "131.9" "131.1" "145.2" "142.5" "152.1" "195.3" "162.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311027039317612116" "False" "High" "IsMasterProtein" "Q9Y3B8" "Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3" "0.000" "False" "19.913" "22" "4" "5" "4" "237" "26.8" "6.87" "19.21" "4" "DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "25996" "ENSG00000076043" "REXO2" "B2R532; hsa:25996; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; Q9Y3B8" "Mitochondrial RNA degradation" "" "1" "0" "0.953" "0.988" "0.967" "0.996" "0.917" "0.929" "0.925" "0.942" "0.952" "975.2" "929.1" "963.4" "943.1" "971.2" "894.5" "906.1" "901.7" "918.2" "928.5" "" "" "" "" "" "" "" "" "" "" "783.3" "670.4" "765.3" "631.8" "671.7" "671.1" "634.4" "658.5" "918.2" "755.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5043456387620106594" "False" "High" "IsMasterProtein" "Q86US8" "Telomerase-binding protein EST1A OS=Homo sapiens OX=9606 GN=SMG6 PE=1 SV=2" "0.000" "False" "19.905" "5" "6" "6" "6" "1419" "160.4" "7.05" "16.82" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23293" "ENSG00000070366" "SMG6" "B7Z874; hsa:23293; O94837; Q86US8; Q86VH6; Q9UF60" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "1.044" "0.944" "1.188" "1.085" "1.035" "1.141" "1.054" "1.091" "1.063" "230.9" "241.2" "218.0" "274.4" "250.5" "238.9" "263.6" "243.4" "251.8" "245.4" "" "" "" "" "" "" "" "" "" "" "185.5" "174.0" "173.2" "183.9" "173.3" "179.3" "184.5" "177.8" "251.8" "199.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4400189645946568146" "False" "High" "IsMasterProtein" "O00488" "Zinc finger protein 593 OS=Homo sapiens OX=9606 GN=ZNF593 PE=1 SV=2" "0.000" "False" "19.880" "31" "3" "4" "3" "134" "15.2" "9.82" "14.82" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12171" "51042" "ENSG00000142684" "ZNF593" "B2R4S0; hsa:51042; O00488; Q5T2H7" "" "" "0" "0" "1.243" "1.046" "1.292" "1.281" "1.194" "1.345" "1.217" "1.189" "1.347" "121.8" "151.4" "127.3" "157.3" "155.9" "145.4" "163.8" "148.1" "144.7" "164.0" "" "" "" "" "" "" "" "" "" "" "97.8" "109.2" "101.1" "105.4" "107.9" "109.1" "114.7" "108.2" "144.7" "133.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2749057131699299074" "False" "High" "IsMasterProtein" "Q9BSY4" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 OS=Homo sapiens OX=9606 GN=CHCHD5 PE=1 SV=1" "0.000" "False" "19.875" "44" "4" "6" "4" "110" "12.4" "6.73" "13.31" "4" "other metabolic processes" "mitochondrion" "" "Pf06747, Pf16860" "84269" "ENSG00000125611" "CHCHD5" "hsa:84269; Q585T4; Q8N8C4; Q9BSY4" "Mitochondrial protein import" "2q13 copy number variation syndrome" "2" "0" "0.978" "0.883" "1.008" "0.998" "0.978" "1.182" "0.784" "0.928" "0.933" "91.3" "89.2" "80.6" "92.0" "91.1" "89.3" "107.9" "71.5" "84.7" "85.2" "" "" "" "" "" "" "" "" "" "" "73.3" "64.4" "64.0" "61.6" "63.0" "67.0" "75.6" "52.2" "84.7" "69.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3918971924664803467" "False" "High" "IsMasterProtein" "Q14088" "Ras-related protein Rab-33A OS=Homo sapiens OX=9606 GN=RAB33A PE=1 SV=2" "0.000" "False" "19.864" "20" "4" "5" "2" "237" "26.6" "7.88" "19.44" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00071" "9363" "ENSG00000134594" "RAB33A" "hsa:9363; Q14088; Q5JUZ6; Q92465" "RAB geranylgeranylation; TBC/RABGAPs" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832676921386861974" "False" "High" "IsMasterProtein" "Q8WW33" "Gametocyte-specific factor 1 OS=Homo sapiens OX=9606 GN=GTSF1 PE=1 SV=2" "0.000" "False" "19.847" "29" "5" "6" "5" "167" "19.3" "6.51" "17.38" "5" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05253" "121355" "ENSG00000170627" "GTSF1" "B3KQ60; hsa:121355; Q0VGM4; Q8N778; Q8WW33" "" "" "0" "0" "0.999" "1.104" "1.074" "1.039" "1.077" "0.897" "1.123" "0.942" "0.979" "258.5" "258.3" "285.5" "277.7" "268.5" "278.4" "231.9" "290.3" "243.6" "253.1" "" "" "" "" "" "" "" "" "" "" "207.6" "186.4" "226.8" "186.1" "185.7" "208.9" "162.4" "212.0" "243.6" "205.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "433749903708797592" "False" "High" "IsMasterProtein" "Q8NB46" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens OX=9606 GN=ANKRD52 PE=1 SV=3" "0.000" "False" "19.839" "5" "5" "5" "5" "1076" "115.0" "6.48" "14.26" "5" "" "" "" "Pf00023, Pf12796" "283373" "ENSG00000139645" "ANKRD52" "A6NE79; B1Q2K2; hsa:283373; Q8NB46" "" "" "0" "0" "1.246" "1.277" "1.210" "1.102" "1.013" "0.998" "1.326" "1.087" "1.086" "124.5" "155.2" "158.9" "150.7" "137.2" "126.1" "124.3" "165.0" "135.4" "135.1" "" "" "" "" "" "" "" "" "" "" "100.0" "112.0" "126.2" "100.9" "94.9" "94.6" "87.0" "120.5" "135.4" "109.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244987817245821138" "False" "High" "IsMasterProtein" "Q14004" "Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2" "0.000" "False" "19.833" "3" "5" "7" "3" "1512" "164.8" "9.69" "21.79" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8621" "ENSG00000065883" "CDK13" "hsa:8621; Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4" "Neutrophil degranulation; TP53 Regulates Transcription of DNA Repair Genes" "" "2" "0" "0.915" "0.881" "0.724" "0.850" "0.897" "0.730" "0.969" "0.828" "0.878" "143.4" "131.3" "126.3" "103.8" "121.9" "128.7" "104.7" "139.0" "118.7" "125.9" "" "" "" "" "" "" "" "" "" "" "115.2" "94.7" "100.3" "69.6" "84.3" "96.5" "73.3" "101.5" "118.7" "102.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677934760849169098" "False" "High" "IsMasterProtein" "Q8IVH4" "Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1" "0.000" "False" "19.832" "11" "4" "4" "4" "418" "46.5" "9.29" "15.22" "4" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03308" "166785" "ENSG00000151611" "MMAA" "B3KX40; hsa:166785; Q495G7; Q8IVH4" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "" "4" "0" "0.956" "0.998" "1.165" "0.979" "1.061" "0.839" "0.933" "0.977" "1.082" "137.8" "131.7" "137.6" "160.5" "134.8" "146.2" "115.6" "128.5" "134.6" "149.0" "" "" "" "" "" "" "" "" "" "" "110.7" "95.0" "109.3" "107.5" "93.2" "109.7" "81.0" "93.9" "134.6" "121.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "727638957837399757" "False" "High" "IsMasterProtein" "O15014" "Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2" "0.000" "False" "19.829" "5" "6" "7" "6" "1411" "151.1" "8.03" "23.46" "6" "other biological processes" "nucleus" "other molecular function" "" "23060" "ENSG00000180357" "ZNF609" "hsa:23060; O15014; Q0D2I2" "" "" "0" "0" "0.923" "1.005" "1.033" "1.015" "1.077" "0.953" "1.018" "1.043" "1.052" "770.1" "710.9" "774.3" "795.3" "781.7" "829.4" "734.1" "783.9" "803.6" "810.2" "" "" "" "" "" "" "" "" "" "" "618.6" "512.9" "615.1" "532.9" "540.6" "622.3" "514.0" "572.5" "803.6" "658.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5337337969812089768" "False" "High" "IsMasterProtein" "P29374" "AT-rich interactive domain-containing protein 4A OS=Homo sapiens OX=9606 GN=ARID4A PE=1 SV=3" "0.000" "False" "19.796" "4" "5" "6" "5" "1257" "142.7" "5.10" "14.26" "5" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf01388, Pf08169, Pf11717" "5926" "ENSG00000032219" "ARID4A" "hsa:5926; P29374; Q15991; Q15992; Q15993" "Potential therapeutics for SARS; HDACs deacetylate histones" "" "2" "0" "0.991" "1.038" "1.069" "0.985" "1.015" "0.998" "1.122" "1.141" "1.044" "388.4" "385.1" "403.1" "415.3" "382.6" "394.4" "387.6" "435.7" "443.2" "405.4" "" "" "" "" "" "" "" "" "" "" "312.0" "277.9" "320.2" "278.3" "264.6" "295.9" "271.4" "318.2" "443.2" "329.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765720071674471585" "False" "High" "IsMasterProtein" "Q15633" "RISC-loading complex subunit TARBP2 OS=Homo sapiens OX=9606 GN=TARBP2 PE=1 SV=3" "0.000" "False" "19.758" "17" "5" "5" "5" "366" "39.0" "6.54" "16.75" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "6895" "ENSG00000139546" "TARBP2" "hsa:6895; Q12878; Q15633; Q8WY32; Q8WY33; Q9BRY2" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6079513439335487390" "False" "High" "IsMasterProtein" "Q9UGV2" "Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2" "0.000" "False" "19.758" "15" "4" "5" "4" "375" "41.4" "5.31" "14.05" "4" "signal transduction;other biological processes" "other cell component" "" "Pf03096" "57446" "ENSG00000101079" "NDRG3" "A2A2S8; E1P5U7; E1P5U8; hsa:57446; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7; Q9H411; Q9H8J6; Q9UGV2" "" "" "0" "0" "1.113" "1.060" "1.267" "1.100" "0.962" "1.165" "1.160" "1.025" "1.100" "234.0" "260.4" "248.2" "296.5" "257.4" "225.2" "272.6" "271.6" "239.9" "257.5" "" "" "" "" "" "" "" "" "" "" "188.0" "187.9" "197.1" "198.6" "178.0" "169.0" "190.9" "198.3" "239.9" "209.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3867715510256549408" "False" "High" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "0.000" "False" "19.747" "9" "6" "6" "4" "651" "70.8" "8.51" "21.01" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "10" "0" "0.961" "1.011" "1.077" "1.060" "1.010" "1.080" "1.037" "0.993" "1.012" "442.5" "425.4" "447.5" "476.5" "469.0" "447.1" "478.0" "459.0" "439.4" "447.7" "" "" "" "" "" "" "" "" "" "" "355.4" "307.0" "355.4" "319.3" "324.3" "335.5" "334.7" "335.2" "439.4" "364.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1614464300928510251" "False" "High" "IsMasterProtein" "P55854" "Small ubiquitin-related modifier 3 OS=Homo sapiens OX=9606 GN=SUMO3 PE=1 SV=2" "0.000" "False" "19.737" "26" "3" "9" "1" "103" "11.6" "5.49" "36.24" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11976" "6612" "ENSG00000184900" "SUMO3" "B2R5X4; B4DUW4; hsa:6612; P55854; Q53HI9; Q6FGD4; Q9BWR4" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "Exercise-induced circadian regulation" "12" "1" "0.999" "1.018" "1.018" "0.997" "0.962" "1.088" "1.054" "1.010" "0.980" "846.1" "845.2" "860.9" "860.9" "843.6" "814.2" "920.2" "891.9" "854.9" "829.2" "" "" "" "" "" "" "" "" "" "" "679.6" "609.8" "683.8" "576.8" "583.4" "610.9" "644.3" "651.4" "854.9" "674.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1753362023353680935" "False" "High" "IsMasterProtein" "Q8WY91" "Peroxynitrite isomerase THAP4 OS=Homo sapiens OX=9606 GN=THAP4 PE=1 SV=2" "0.000" "False" "19.727" "9" "3" "3" "3" "577" "62.9" "9.28" "11.45" "3" "other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05485, Pf08768" "51078" "ENSG00000176946" "THAP4" "hsa:51078; Q53NU7; Q6GRN0; Q6IPJ3; Q8WY91; Q9NW26; Q9Y325" "" "2q37 copy number variation syndrome" "1" "0" "1.389" "1.007" "1.460" "1.455" "1.424" "1.405" "1.202" "1.636" "1.625" "40.3" "56.0" "40.6" "58.9" "58.7" "57.4" "56.7" "48.5" "66.0" "65.6" "" "" "" "" "" "" "" "" "" "" "32.4" "40.4" "32.3" "39.5" "40.6" "43.1" "39.7" "35.4" "66.0" "53.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3564822305630524625" "False" "High" "IsMasterProtein" "Q96M27" "Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1" "0.000" "False" "19.709" "11" "5" "7" "5" "445" "46.7" "5.83" "21.18" "5" "" "ER/Golgi;other cell component" "other molecular function" "Pf01931" "133619" "ENSG00000164244" "PRRC1" "hsa:133619; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3; Q96M27" "" "" "0" "0" "1.002" "0.951" "1.046" "0.950" "0.981" "0.966" "0.981" "0.886" "1.033" "635.6" "637.2" "604.3" "664.8" "603.7" "623.7" "614.0" "623.8" "563.3" "656.8" "" "" "" "" "" "" "" "" "" "" "510.5" "459.8" "480.1" "445.4" "417.5" "468.0" "429.9" "455.6" "563.3" "534.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3125530162626484972" "False" "High" "IsMasterProtein" "Q9Y2L9" "Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LRCH1 PE=1 SV=3" "0.000" "False" "19.691" "8" "5" "5" "5" "728" "80.8" "5.94" "17.34" "5" "other biological processes" "other cell component" "" "Pf00307, Pf13855" "23143" "ENSG00000136141" "LRCH1" "B7ZLL5; F8W6F0; hsa:23143; Q17R43; Q2KHR1; Q5TBU9; Q7Z5F6; Q7Z5F7; Q9Y2L9" "" "" "0" "0" "0.992" "0.913" "1.064" "1.019" "1.026" "1.030" "0.893" "0.955" "0.935" "311.3" "308.9" "284.2" "331.2" "317.2" "319.4" "320.7" "278.0" "297.2" "290.9" "" "" "" "" "" "" "" "" "" "" "250.0" "222.9" "225.7" "221.9" "219.3" "239.6" "224.6" "203.0" "297.2" "236.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4867234808288682170" "False" "High" "IsMasterProtein" "Q8N1F8" "Serine/threonine-protein kinase 11-interacting protein OS=Homo sapiens OX=9606 GN=STK11IP PE=1 SV=4" "0.000" "False" "19.675" "5" "4" "5" "4" "1088" "120.2" "5.36" "16.68" "4" "other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15904" "114790" "ENSG00000144589" "STK11IP" "C9JQV3; hsa:114790; Q8N1F8; Q8NAW9; Q8WXE4; Q96CN3; Q96PY9" "Neutrophil degranulation" "" "1" "0" "1.076" "1.016" "1.208" "1.036" "0.979" "1.079" "0.912" "1.012" "1.170" "127.3" "137.0" "129.3" "153.8" "131.9" "124.7" "137.4" "116.2" "128.9" "149.0" "" "" "" "" "" "" "" "" "" "" "102.3" "98.8" "102.7" "103.0" "91.2" "93.5" "96.2" "84.8" "128.9" "121.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6155932716542002822" "False" "High" "IsMasterProtein" "P06239" "Tyrosine-protein kinase Lck OS=Homo sapiens OX=9606 GN=LCK PE=1 SV=6" "0.000" "False" "19.664" "12" "5" "10" "3" "509" "58.0" "5.36" "33.66" "5" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "3932" "ENSG00000182866" "LCK" "D3DPP8; hsa:3932; P06239; P07100; Q12850; Q13152; Q5TDH8; Q5TDH9; Q7RTZ3; Q96DW4; Q9NYT8" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; DAP12 signaling; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; RHOH GTPase cycle; CD28 dependent Vav1 pathway; Nef Mediated CD4 Down-regulation; Interleukin-2 signaling; Nef and signal transduction; PECAM1 interactions; CTLA4 inhibitory signaling; FLT3 signaling through SRC family kinases" "Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Inflammatory response pathway; Cancer immunotherapy by PD-1 blockade; IL-18 signaling pathway; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; TAR syndrome; Interferon type I signaling pathways; Notch signaling pathway; T-cell receptor signaling pathway" "40" "0" "1.029" "1.064" "1.155" "1.121" "1.113" "1.271" "1.024" "0.986" "1.126" "145.2" "149.4" "154.5" "167.8" "162.8" "161.7" "184.5" "148.7" "143.2" "163.5" "" "" "" "" "" "" "" "" "" "" "116.6" "107.8" "122.7" "112.4" "112.6" "121.3" "129.2" "108.6" "143.2" "133.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7993967056221403717" "False" "High" "IsMasterProtein" "Q9BU02" "Thiamine-triphosphatase OS=Homo sapiens OX=9606 GN=THTPA PE=1 SV=3" "0.000" "False" "19.649" "20" "4" "4" "4" "230" "25.6" "4.82" "14.37" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01928" "79178" "ENSG00000259431" "THTPA" "D3DS50; G3V4J3; hsa:79178; Q9BU02" "Vitamin B1 (thiamin) metabolism" "" "1" "0" "0.964" "0.898" "1.009" "1.049" "0.936" "0.917" "0.922" "0.937" "1.028" "232.6" "224.3" "208.9" "234.8" "244.0" "217.8" "213.3" "214.4" "218.0" "239.0" "" "" "" "" "" "" "" "" "" "" "186.8" "161.8" "165.9" "157.3" "168.7" "163.4" "149.3" "156.6" "218.0" "194.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1553540605597619179" "False" "High" "IsMasterProtein" "P51965" "Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1" "0.000" "False" "19.644" "19" "3" "4" "1" "193" "21.4" "8.53" "13.87" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7324" "ENSG00000170142" "UBE2E1" "B2RBX4; C9J8K2; hsa:7324; K4DI90; P51965" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome" "23" "0" "0.956" "0.856" "0.771" "0.655" "0.932" "0.782" "0.714" "1.002" "0.856" "137.2" "131.1" "117.4" "105.7" "89.9" "127.9" "107.3" "97.9" "137.4" "117.5" "" "" "" "" "" "" "" "" "" "" "110.2" "94.6" "93.2" "70.8" "62.2" "96.0" "75.1" "71.5" "137.4" "95.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4814601069630724909" "False" "High" "IsMasterProtein" "Q15906" "Vacuolar protein sorting-associated protein 72 homolog OS=Homo sapiens OX=9606 GN=VPS72 PE=1 SV=1" "0.000" "False" "19.620" "12" "4" "5" "4" "364" "40.6" "6.48" "14.67" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05764, Pf08265" "6944" "ENSG00000163159" "VPS72" "A6NLK9; A6PW55; hsa:6944; Q15906; Q53GJ2; Q5U0R4" "HATs acetylate histones" "" "1" "0" "1.008" "0.979" "0.950" "0.924" "0.933" "0.911" "1.030" "0.963" "0.890" "448.8" "452.2" "439.2" "426.2" "414.5" "418.8" "409.0" "462.2" "432.1" "399.2" "" "" "" "" "" "" "" "" "" "" "360.5" "326.3" "348.9" "285.6" "286.7" "314.2" "286.4" "337.5" "432.1" "324.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213215215106064220" "False" "High" "IsMasterProtein" "Q8WZ82" "Esterase OVCA2 OS=Homo sapiens OX=9606 GN=OVCA2 PE=1 SV=1" "0.000" "False" "19.613" "16" "3" "4" "3" "227" "24.4" "6.89" "14.58" "3" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf03959" "124641" "ENSG00000262664" "OVCA2" "hsa:124641; Q86XN3; Q8IW87; Q8WZ82; Q9UCX9" "" "" "0" "0" "0.968" "0.903" "0.941" "1.021" "0.930" "1.036" "0.994" "0.956" "0.983" "259.7" "251.3" "234.5" "244.3" "265.1" "241.4" "269.0" "258.2" "248.2" "255.3" "" "" "" "" "" "" "" "" "" "" "208.6" "181.3" "186.3" "163.7" "183.4" "181.2" "188.3" "188.5" "248.2" "207.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3357604607996684691" "False" "High" "IsMasterProtein" "Q9NX58" "Cell growth-regulating nucleolar protein OS=Homo sapiens OX=9606 GN=LYAR PE=1 SV=3" "0.000" "False" "19.592" "11" "3" "4" "3" "379" "43.6" "9.57" "11.79" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08790, Pf17848" "55646" "ENSG00000145220" "LYAR" "D3DVS4; hsa:55646; Q6FI78; Q9NX58; Q9NYS1" "" "" "0" "0" "0.951" "1.046" "1.298" "1.159" "0.997" "1.292" "0.988" "1.147" "1.094" "174.6" "166.0" "182.6" "226.7" "202.4" "174.2" "225.6" "172.6" "200.4" "191.0" "" "" "" "" "" "" "" "" "" "" "140.2" "119.8" "145.0" "151.9" "140.0" "130.7" "157.9" "126.0" "200.4" "155.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377000983824553191" "False" "High" "IsMasterProtein" "Q8N5N7" "Large ribosomal subunit protein mL50 OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "0.000" "False" "19.560" "35" "4" "4" "4" "158" "18.3" "7.88" "17.65" "4" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.058" "1.063" "1.096" "1.093" "1.094" "1.100" "1.033" "1.034" "1.012" "246.2" "260.5" "261.8" "269.9" "269.2" "269.4" "270.9" "254.4" "254.7" "249.1" "" "" "" "" "" "" "" "" "" "" "197.8" "188.0" "208.0" "180.8" "186.2" "202.1" "189.7" "185.8" "254.7" "202.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4935758421494429625" "False" "High" "IsMasterProtein" "P54277" "PMS1 protein homolog 1 OS=Homo sapiens OX=9606 GN=PMS1 PE=1 SV=1" "0.000" "False" "19.557" "6" "7" "7" "7" "932" "105.8" "6.67" "18.38" "7" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01119, Pf02518" "5378" "ENSG00000064933" "PMS1" "D3DPI1; hsa:5378; P54277; Q4VAL4; Q5FBZ3; Q5FBZ6; Q5FBZ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695950193153579401" "False" "High" "IsMasterProtein" "Q6VEQ5" "WAS protein family homolog 2 OS=Homo sapiens OX=9606 GN=WASH2P PE=2 SV=2" "0.000" "False" "19.555" "16" "7" "7" "3" "465" "50.3" "5.71" "19.97" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH2P" "Q6VEQ5" "" "" "0" "2" "0.976" "0.958" "0.946" "1.015" "0.950" "0.883" "0.930" "0.908" "1.001" "603.3" "588.8" "578.0" "570.8" "612.5" "572.9" "532.8" "561.3" "547.8" "604.0" "" "" "" "" "" "" "" "" "" "" "484.6" "424.8" "459.1" "382.5" "423.6" "429.9" "373.0" "409.9" "547.8" "491.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316200197019601200" "False" "High" "IsMasterProtein" "Q9Y3I1" "F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1" "0.000" "False" "19.551" "9" "4" "4" "4" "522" "58.5" "6.55" "14.64" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00646, Pf11566" "25793" "ENSG00000100225" "FBXO7" "B4DNB3; B4DWX5; hsa:25793; Q5TGC4; Q5TI86; Q96HM6; Q9UF21; Q9UKT2; Q9Y3I1" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.096" "1.073" "1.007" "1.101" "1.151" "1.041" "1.256" "1.113" "1.044" "543.0" "595.2" "582.6" "546.6" "597.7" "624.9" "565.5" "681.8" "604.2" "567.0" "" "" "" "" "" "" "" "" "" "" "436.2" "429.4" "462.8" "366.2" "413.4" "468.9" "395.9" "497.9" "604.2" "461.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696690186535498755" "False" "High" "IsMasterProtein" "Q9NPJ3" "Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1" "0.000" "False" "19.545" "18" "2" "3" "2" "140" "15.0" "9.14" "13.95" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf03061" "55856" "ENSG00000112304" "ACOT13" "F5H2L4; hsa:55856; O95549; Q9NPJ3" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "1.003" "1.033" "0.987" "1.043" "1.009" "0.952" "0.943" "0.928" "0.931" "541.5" "543.2" "559.3" "534.6" "564.8" "546.4" "515.4" "510.4" "502.5" "504.2" "" "" "" "" "" "" "" "" "" "" "434.9" "392.0" "444.3" "358.2" "390.6" "410.0" "360.9" "372.7" "502.5" "410.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2438255133986472284" "False" "High" "IsMasterProtein" "Q9H8H0" "Nucleolar protein 11 OS=Homo sapiens OX=9606 GN=NOL11 PE=1 SV=1" "0.000" "False" "19.539" "7" "5" "5" "5" "719" "81.1" "6.07" "18.21" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf08168, Pf20998" "25926" "ENSG00000130935" "NOL11" "B7Z5V9; hsa:25926; Q7L5S1; Q9H8H0; Q9UG18" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.999" "1.018" "1.053" "0.982" "0.987" "0.970" "0.983" "1.007" "0.987" "797.3" "796.7" "811.9" "839.9" "782.9" "787.2" "773.3" "783.4" "802.6" "787.0" "" "" "" "" "" "" "" "" "" "" "640.4" "574.9" "644.9" "562.7" "541.5" "590.6" "541.4" "572.1" "802.6" "640.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338672527715775280" "False" "High" "IsMasterProtein" "Q8IWL3" "Iron-sulfur cluster co-chaperone protein HscB OS=Homo sapiens OX=9606 GN=HSCB PE=1 SV=3" "0.000" "False" "19.527" "23" "5" "5" "5" "235" "27.4" "7.69" "17.96" "5" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf07743, Pf18256" "150274" "ENSG00000100209" "HSCB" "hsa:150274; Q8IWL3; Q9BWS7" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "3" "0" "0.942" "1.006" "0.894" "0.963" "0.955" "0.925" "0.919" "0.964" "0.964" "617.1" "581.4" "620.9" "552.0" "594.1" "589.4" "571.0" "566.9" "594.8" "594.7" "" "" "" "" "" "" "" "" "" "" "495.6" "419.5" "493.2" "369.8" "410.9" "442.3" "399.8" "414.0" "594.8" "483.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723466212240730486" "False" "High" "IsMasterProtein" "Q13574" "Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=4" "0.000" "False" "19.514" "4" "3" "4" "3" "928" "103.9" "8.05" "13.35" "3" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00023, Pf00130, Pf00609, Pf00781" "8525" "ENSG00000149091" "DGKZ" "B7Z2M9; B7Z6M3; E9PPW4; F6UCU9; G3V0F6; hsa:8525; J3KNJ6; O00542; Q13574; Q6ZVG7; Q8IVW9" "Effects of PIP2 hydrolysis" "Myometrial relaxation and contraction pathways; Leptin-insulin signaling overlap; Glycerolipids and glycerophospholipids; Modulators of TCR signaling and T cell activation" "5" "0" "0.994" "0.957" "0.972" "1.143" "0.933" "1.002" "1.012" "0.937" "1.095" "206.4" "205.0" "197.6" "200.6" "235.9" "192.5" "206.8" "208.8" "193.4" "226.0" "" "" "" "" "" "" "" "" "" "" "165.7" "147.9" "156.9" "134.4" "163.1" "144.4" "144.8" "152.5" "193.4" "183.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7125243051286610373" "False" "High" "IsMasterProtein" "Q96SN8" "CDK5 regulatory subunit-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK5RAP2 PE=1 SV=5" "0.000" "False" "19.507" "3" "5" "6" "5" "1893" "214.9" "5.58" "18.78" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07989" "55755" "ENSG00000136861" "CDK5RAP2" "hsa:55755; Q5JV18; Q7Z3L4; Q7Z3U1; Q7Z7I6; Q96SN8; Q9BSW0; Q9H6J6; Q9HCD9; Q9NV90; Q9UIW9" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8571260626068012330" "False" "High" "IsMasterProtein" "Q9NXK8" "F-box/LRR-repeat protein 12 OS=Homo sapiens OX=9606 GN=FBXL12 PE=1 SV=1" "0.000" "False" "19.507" "19" "4" "6" "4" "326" "37.0" "8.79" "13.46" "4" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937" "54850" "ENSG00000127452" "FBXL12" "B3KSJ8; hsa:54850; Q9H5K4; Q9NXK8" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.134" "1.144" "1.022" "0.955" "1.000" "0.917" "1.105" "0.950" "1.222" "94.4" "107.1" "108.0" "96.5" "90.2" "94.5" "86.6" "104.3" "89.7" "115.4" "" "" "" "" "" "" "" "" "" "" "75.8" "77.3" "85.8" "64.7" "62.3" "70.9" "60.6" "76.2" "89.7" "93.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4261642457935236614" "False" "High" "IsMasterProtein" "Q9NS73" "MAP3K12-binding inhibitory protein 1 OS=Homo sapiens OX=9606 GN=MBIP PE=1 SV=2" "0.000" "False" "19.488" "12" "4" "4" "4" "344" "39.3" "7.24" "14.87" "4" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "" "51562" "ENSG00000151332" "MBIP" "hsa:51562; Q86TZ2; Q96AS5; Q9BS93; Q9NS73; Q9NZE1" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "1.019" "0.944" "0.951" "0.974" "1.040" "0.997" "0.993" "1.111" "0.946" "474.4" "483.6" "447.7" "451.1" "461.9" "493.3" "473.2" "471.1" "527.2" "448.8" "" "" "" "" "" "" "" "" "" "" "381.1" "348.9" "355.6" "302.2" "319.5" "370.1" "331.3" "344.0" "527.2" "365.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387955691257056682" "False" "High" "IsMasterProtein" "O43318" "Mitogen-activated protein kinase kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP3K7 PE=1 SV=1" "0.000" "False" "19.484" "9" "6" "8" "6" "606" "67.2" "7.11" "16.44" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "6885" "ENSG00000135341" "MAP3K7" "B2RE27; E1P523; hsa:6885; O43317; O43318; O43319; Q5TDN2; Q5TDN3; Q5TDT7; Q9NTR3; Q9NZ70" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNA role in immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "50" "0" "0.999" "0.974" "0.979" "0.918" "1.003" "1.036" "1.025" "0.985" "0.983" "649.7" "649.3" "633.1" "635.8" "596.4" "651.9" "672.9" "665.9" "640.1" "638.9" "" "" "" "" "" "" "" "" "" "" "521.9" "468.5" "502.9" "426.0" "412.5" "489.1" "471.2" "486.3" "640.1" "519.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6809936595777039335" "False" "High" "IsMasterProtein" "Q69YN4" "Protein virilizer homolog OS=Homo sapiens OX=9606 GN=VIRMA PE=1 SV=2" "0.000" "False" "19.466" "3" "5" "5" "5" "1812" "201.9" "5.01" "16.36" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15912" "25962" "ENSG00000164944" "VIRMA" "hsa:25962; Q2M1N0; Q69YN4; Q6AHX9; Q6NT78; Q7Z6C7; Q8IXH4; Q9BTH4; Q9H9C9; Q9NWR3; Q9P2B8; Q9UFW1" "" "" "0" "0" "0.911" "1.054" "1.013" "0.990" "1.003" "1.012" "1.000" "1.047" "1.016" "385.0" "350.8" "405.8" "389.8" "381.1" "386.1" "389.7" "384.9" "403.3" "391.0" "" "" "" "" "" "" "" "" "" "" "309.2" "253.1" "322.4" "261.2" "263.6" "289.7" "272.9" "281.1" "403.3" "318.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7544877575899964257" "False" "High" "IsMasterProtein" "Q96C57" "Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2" "0.000" "False" "19.441" "18" "3" "4" "3" "262" "28.2" "9.42" "14.65" "3" "cell-cell signaling;signal transduction;other biological processes" "nucleus" "" "" "64897" "ENSG00000157895" "CUSTOS" "Q53HF0; Q96C57; Q9H9Z7" "" "" "0" "0" "0.959" "0.987" "0.896" "0.961" "0.955" "0.943" "0.963" "0.857" "0.928" "271.4" "260.3" "267.7" "243.2" "260.8" "259.1" "255.9" "261.2" "232.5" "251.8" "" "" "" "" "" "" "" "" "" "" "218.0" "187.8" "212.7" "163.0" "180.4" "194.4" "179.1" "190.8" "232.5" "204.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5758316461638693187" "False" "High" "IsMasterProtein" "Q05519" "Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1" "0.000" "False" "19.432" "10" "3" "5" "3" "484" "53.5" "10.52" "15.80" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00076" "9295" "ENSG00000116754" "SRSF11" "hsa:9295; Q05519; Q5T758; Q8IWE6" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "5" "0" "1.038" "1.198" "0.960" "0.938" "1.023" "0.991" "1.045" "1.052" "1.089" "174.5" "181.2" "209.1" "167.6" "163.6" "178.4" "172.9" "182.3" "183.7" "190.0" "" "" "" "" "" "" "" "" "" "" "140.2" "130.7" "166.1" "112.3" "113.2" "133.9" "121.1" "133.2" "183.7" "154.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7798556211851200264" "False" "High" "IsMasterProtein" "Q96AX1" "Vacuolar protein sorting-associated protein 33A OS=Homo sapiens OX=9606 GN=VPS33A PE=1 SV=1" "0.000" "False" "19.430" "10" "6" "7" "6" "596" "67.6" "6.96" "18.81" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00995" "65082" "ENSG00000139719" "VPS33A" "Q547V4; Q96AX1; Q9H5Q0" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Network map of SARS-CoV-2 signaling pathway" "4" "0" "0.920" "0.899" "1.069" "0.881" "0.775" "0.959" "0.842" "0.993" "0.846" "242.6" "223.2" "218.2" "259.4" "213.7" "188.0" "232.5" "204.4" "240.8" "205.3" "" "" "" "" "" "" "" "" "" "" "194.8" "161.0" "173.3" "173.8" "147.8" "141.1" "162.8" "149.2" "240.8" "166.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293840026169595064" "False" "High" "IsMasterProtein" "Q6ZVK8" "8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens OX=9606 GN=NUDT18 PE=1 SV=3" "0.000" "False" "19.415" "17" "4" "5" "4" "323" "35.5" "6.23" "17.69" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf00293" "79873" "ENSG00000275074" "NUDT18" "hsa:79873; Q6ZVK8; Q8IZ75; Q9H687" "" "" "0" "0" "0.996" "0.893" "1.328" "1.053" "0.910" "1.263" "1.012" "0.973" "1.042" "517.6" "515.4" "462.1" "687.6" "545.2" "471.0" "653.8" "524.0" "503.6" "539.6" "" "" "" "" "" "" "" "" "" "" "415.7" "371.9" "367.1" "460.7" "377.1" "353.4" "457.7" "382.7" "503.6" "438.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2492385812914646204" "False" "High" "IsMasterProtein" "O14730" "Serine/threonine-protein kinase RIO3 OS=Homo sapiens OX=9606 GN=RIOK3 PE=1 SV=2" "0.000" "False" "19.399" "11" "6" "6" "6" "519" "59.1" "5.76" "20.48" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01163" "8780" "ENSG00000101782" "RIOK3" "O14730; Q8IXN9" "Major pathway of rRNA processing in the nucleolus and cytosol" "Hematopoietic stem cell differentiation" "2" "0" "0.937" "0.942" "0.904" "0.893" "0.920" "0.856" "0.993" "0.941" "0.950" "762.2" "714.3" "718.3" "688.7" "680.3" "701.5" "652.4" "757.2" "717.5" "724.1" "" "" "" "" "" "" "" "" "" "" "612.2" "515.5" "570.6" "461.4" "470.5" "526.3" "456.8" "553.0" "717.5" "588.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5878749091954707236" "False" "High" "IsMasterProtein" "Q9NXA8" "NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT5 PE=1 SV=2" "0.000" "False" "19.396" "15" "3" "3" "3" "310" "33.9" "8.47" "12.67" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf02146" "23408" "ENSG00000124523" "SIRT5" "B4DFM4; B4DYJ5; F5H5Z9; hsa:23408; Q5T294; Q5T295; Q9NXA8; Q9Y6E6" "Transcriptional activation of mitochondrial biogenesis" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "4" "0" "1.143" "1.154" "1.181" "1.136" "1.226" "1.095" "1.073" "1.149" "1.123" "213.7" "244.1" "246.5" "252.4" "242.7" "261.9" "233.9" "229.2" "245.4" "239.9" "" "" "" "" "" "" "" "" "" "" "171.6" "176.2" "195.8" "169.1" "167.8" "196.5" "163.8" "167.4" "245.4" "195.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8897927759308668761" "False" "High" "IsMasterProtein" "Q3KQV9" "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens OX=9606 GN=UAP1L1 PE=1 SV=2" "0.000" "False" "19.355" "9" "4" "4" "3" "507" "57.0" "6.32" "15.28" "4" "other metabolic processes" "" "other molecular function" "Pf01704" "91373" "ENSG00000197355" "UAP1L1" "A2AMJ8; hsa:91373; Q3KQV9; Q5SPZ2; Q69YQ3; Q6ZR38" "" "" "0" "0" "1.036" "1.013" "1.066" "0.984" "0.985" "1.040" "1.011" "1.068" "1.084" "216.3" "224.0" "219.0" "230.5" "212.7" "213.1" "224.9" "218.7" "230.9" "234.4" "" "" "" "" "" "" "" "" "" "" "173.7" "161.6" "174.0" "154.4" "147.1" "159.9" "157.5" "159.7" "230.9" "190.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5055182102876441761" "False" "High" "IsMasterProtein" "Q9BRT9" "DNA replication complex GINS protein SLD5 OS=Homo sapiens OX=9606 GN=GINS4 PE=1 SV=1" "0.000" "False" "19.350" "20" "4" "8" "4" "223" "26.0" "4.98" "23.71" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf05916, Pf16922" "84296" "ENSG00000147536" "GINS4" "B2R8H5; D3DSY0; hsa:84296; Q8N648; Q9BRT9" "Unwinding of DNA" "" "1" "0" "1.042" "1.022" "1.004" "1.019" "1.028" "1.045" "1.058" "1.130" "1.018" "612.5" "638.4" "626.1" "615.2" "624.4" "629.4" "640.2" "647.9" "692.2" "623.2" "" "" "" "" "" "" "" "" "" "" "491.9" "460.6" "497.3" "412.2" "431.8" "472.2" "448.2" "473.2" "692.2" "506.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706468280429092974" "False" "High" "IsMasterProtein" "Q9Y3S2" "Zinc finger protein 330 OS=Homo sapiens OX=9606 GN=ZNF330 PE=1 SV=1" "0.000" "False" "19.346" "16" "4" "5" "4" "320" "36.2" "6.16" "15.45" "4" "" "nucleus;other cell component" "other molecular function" "Pf06524" "27309" "ENSG00000109445" "ZNF330" "B2RDA3; hsa:27309; Q9Y3S2" "" "" "0" "0" "1.110" "1.009" "0.963" "0.939" "0.990" "0.952" "0.907" "0.963" "0.978" "285.5" "316.9" "288.0" "274.8" "268.1" "282.7" "271.7" "259.1" "274.9" "279.0" "" "" "" "" "" "" "" "" "" "" "229.3" "228.7" "228.8" "184.1" "185.4" "212.1" "190.2" "189.2" "274.9" "226.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3106381619938843905" "False" "High" "IsMasterProtein" "Q5TA31" "E3 ubiquitin-protein ligase RNF187 OS=Homo sapiens OX=9606 GN=RNF187 PE=1 SV=2" "0.000" "False" "19.339" "19" "4" "6" "4" "235" "26.2" "5.95" "15.90" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15227" "149603" "ENSG00000168159; ENSG00000285426" "RNF187" "A6NL57; hsa:149603; Q5TA31; Q6P2J7; Q6PJR0" "" "" "0" "0" "1.043" "1.047" "0.933" "1.038" "0.986" "0.979" "1.121" "0.909" "0.990" "321.2" "335.1" "336.4" "299.7" "333.5" "316.8" "314.4" "360.1" "292.0" "317.9" "" "" "" "" "" "" "" "" "" "" "258.0" "241.8" "267.3" "200.8" "230.6" "237.7" "220.1" "263.0" "292.0" "258.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485362868972298733" "False" "High" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "0.000" "False" "19.332" "43" "4" "19" "4" "115" "12.5" "7.88" "45.48" "4" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Adipogenesis; Spinal cord injury; HDAC6 interactions in the central nervous system" "6" "0" "1.020" "1.039" "1.084" "1.070" "1.046" "1.099" "1.016" "0.940" "0.981" "464.4" "473.8" "482.4" "503.4" "496.7" "485.6" "510.2" "471.7" "436.7" "455.6" "" "" "" "" "" "" "" "" "" "" "373.0" "341.9" "383.2" "337.3" "343.5" "364.4" "357.2" "344.5" "436.7" "370.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369433181564394735" "False" "High" "IsMasterProtein" "P08708" "Small ribosomal subunit protein eS17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "0.000" "False" "19.316" "49" "4" "4" "4" "135" "15.5" "9.85" "14.64" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.008" "1.163" "1.004" "1.266" "1.253" "1.315" "1.396" "1.216" "1.108" "276.6" "278.8" "321.6" "277.7" "350.2" "346.5" "363.6" "386.2" "336.3" "306.6" "" "" "" "" "" "" "" "" "" "" "222.1" "201.1" "255.4" "186.1" "242.2" "260.0" "254.6" "282.0" "336.3" "249.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4572306403840384650" "False" "High" "IsMasterProtein" "O75208" "Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1" "0.000" "False" "19.308" "17" "4" "4" "4" "318" "35.5" "5.94" "12.60" "4" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08511, Pf21392" "57017" "ENSG00000088682" "COQ9" "A8K3L2; hsa:57017; O75208; Q7L5V7; Q7Z5T6; Q8NBL4; Q9NTJ2; Q9P056" "Ubiquinol biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "938742805709954505" "False" "High" "IsMasterProtein" "Q9H3F6" "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1" "0.000" "False" "19.280" "20" "6" "6" "6" "313" "35.4" "6.34" "18.94" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02214" "83892" "ENSG00000110906" "KCTD10" "hsa:83892; Q53HN2; Q59FV1; Q6PL47; Q96SU0; Q9H3F6" "" "" "0" "0" "1.015" "0.961" "0.998" "0.956" "0.994" "1.014" "1.017" "0.969" "0.938" "350.0" "355.2" "336.3" "349.4" "334.7" "348.0" "354.8" "356.0" "339.1" "328.2" "" "" "" "" "" "" "" "" "" "" "281.1" "256.3" "267.1" "234.1" "231.5" "261.1" "248.4" "260.0" "339.1" "266.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472695818303021401" "False" "High" "IsMasterProtein" "P22087" "rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2" "0.000" "False" "19.267" "11" "3" "5" "3" "321" "33.8" "10.18" "17.67" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01269" "2091" "ENSG00000105202; ENSG00000280548" "FBL" "B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "Rubinstein-Taybi syndrome 1" "3" "0" "1.173" "1.321" "1.085" "1.191" "1.140" "0.914" "1.231" "1.217" "1.177" "314.7" "369.3" "415.6" "341.4" "375.0" "358.8" "287.7" "387.4" "383.2" "370.3" "" "" "" "" "" "" "" "" "" "" "252.8" "266.5" "330.1" "228.7" "259.3" "269.2" "201.4" "282.9" "383.2" "301.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157641750499335080" "False" "High" "IsMasterProtein" "Q9C0C7" "Activating molecule in BECN1-regulated autophagy protein 1 OS=Homo sapiens OX=9606 GN=AMBRA1 PE=1 SV=2" "0.000" "False" "19.244" "4" "4" "4" "4" "1298" "142.4" "7.18" "12.87" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "55626" "ENSG00000110497" "AMBRA1" "A6XN33; D3DQP8; G3V193; hsa:55626; Q86XD6; Q9C0C7; Q9H8Z0; Q9NXE7" "Macroautophagy" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism" "6" "0" "1.015" "0.980" "1.111" "0.977" "0.933" "1.097" "1.055" "1.036" "1.081" "350.7" "355.9" "343.6" "389.6" "342.7" "327.1" "384.6" "370.2" "363.3" "379.0" "" "" "" "" "" "" "" "" "" "" "281.7" "256.8" "273.0" "261.0" "237.0" "245.4" "269.3" "270.4" "363.3" "308.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5575516958920561508" "False" "High" "IsMasterProtein" "Q9H1Y0" "Autophagy protein 5 OS=Homo sapiens OX=9606 GN=ATG5 PE=1 SV=2" "0.000" "False" "19.231" "14" "3" "4" "3" "275" "32.4" "5.77" "13.85" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04106, Pf20637, Pf20638" "9474" "ENSG00000057663" "ATG5" "hsa:9474; O60875; Q5JVR2; Q68DI4; Q9H1Y0; Q9H2B8; Q9HCZ7" "Negative regulators of DDX58/IFIH1 signaling; Macroautophagy; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "Nanoparticle triggered autophagic cell death; Novel intracellular components of RIG-I-like receptor pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Cytosolic DNA-sensing pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "13" "0" "0.957" "0.885" "0.868" "0.924" "0.971" "0.904" "0.900" "0.950" "0.900" "589.5" "564.1" "521.7" "511.6" "544.9" "572.2" "533.0" "530.6" "559.9" "530.6" "" "" "" "" "" "" "" "" "" "" "473.5" "407.0" "414.4" "342.8" "376.9" "429.3" "373.1" "387.5" "559.9" "431.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7765133988428364561" "False" "High" "IsMasterProtein" "Q58WW2" "DDB1- and CUL4-associated factor 6 OS=Homo sapiens OX=9606 GN=DCAF6 PE=1 SV=1" "0.000" "False" "19.216" "6" "4" "5" "4" "860" "96.2" "5.27" "16.62" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55827" "ENSG00000143164" "DCAF6" "A2A295; B4DNB8; hsa:55827; Q58WW2; Q7L8I0; Q8IXH3; Q8TB19" "Neddylation" "" "1" "0" "0.955" "0.861" "0.930" "0.925" "0.935" "0.932" "0.850" "0.970" "0.921" "531.2" "507.1" "457.2" "494.1" "491.3" "496.9" "494.9" "451.4" "515.1" "489.2" "" "" "" "" "" "" "" "" "" "" "426.7" "365.9" "363.2" "331.0" "339.8" "372.8" "346.5" "329.7" "515.1" "397.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516150800733119915" "False" "High" "IsMasterProtein" "P55011" "Solute carrier family 12 member 2 OS=Homo sapiens OX=9606 GN=SLC12A2 PE=1 SV=1" "0.000" "False" "19.214" "4" "3" "3" "3" "1212" "131.4" "6.40" "11.98" "3" "cell-cell signaling;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00324, Pf03522, Pf08403" "6558" "ENSG00000064651" "SLC12A2" "hsa:6558; P55011; Q8N713; Q8WWH7" "Cation-coupled Chloride cotransporters" "Polycystic kidney disease pathway" "2" "0" "0.804" "0.777" "0.858" "0.892" "0.793" "1.125" "0.991" "0.942" "1.010" "177.5" "142.7" "137.9" "152.2" "158.3" "140.7" "199.7" "176.0" "167.2" "179.2" "" "" "" "" "" "" "" "" "" "" "142.6" "103.0" "109.5" "102.0" "109.5" "105.6" "139.8" "128.5" "167.2" "145.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4174205388023222362" "False" "High" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "0.000" "False" "19.213" "12" "3" "5" "3" "258" "28.8" "6.65" "20.71" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "0" "1.023" "0.981" "1.000" "1.053" "0.995" "0.983" "0.997" "1.036" "1.024" "771.6" "789.4" "756.8" "771.2" "812.3" "767.6" "758.2" "769.1" "799.6" "789.7" "" "" "" "" "" "" "" "" "" "" "619.7" "569.6" "601.1" "516.7" "561.8" "575.9" "530.9" "561.7" "799.6" "642.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753763641550930270" "False" "High" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "0.000" "False" "19.208" "16" "4" "4" "4" "372" "42.0" "5.31" "13.17" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "17q12 copy number variation syndrome" "6" "0" "1.033" "1.029" "1.038" "0.944" "1.071" "1.072" "1.018" "1.019" "1.096" "285.7" "295.1" "293.9" "296.4" "269.7" "306.0" "306.3" "290.9" "291.1" "313.1" "" "" "" "" "" "" "" "" "" "" "229.5" "213.0" "233.4" "198.6" "186.5" "229.6" "214.5" "212.4" "291.1" "254.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5046480723636324863" "False" "High" "IsMasterProtein" "Q9Y314" "Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1" "0.000" "False" "19.186" "10" "3" "5" "3" "301" "33.2" "8.82" "19.56" "3" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15906" "51070" "ENSG00000142546" "NOSIP" "Q96FD2; Q9Y314" "NOSIP mediated eNOS trafficking" "" "1" "0" "1.025" "1.050" "0.937" "1.009" "1.036" "0.994" "1.160" "1.117" "1.053" "498.4" "510.7" "523.3" "467.2" "503.0" "516.4" "495.5" "578.3" "556.6" "524.9" "" "" "" "" "" "" "" "" "" "" "400.3" "368.5" "415.7" "313.0" "347.9" "387.4" "346.9" "422.3" "556.6" "426.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532821643516687408" "False" "High" "IsMasterProtein" "Q6P158" "Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2" "0.000" "False" "19.171" "4" "5" "5" "4" "1386" "155.5" "7.71" "14.12" "5" "" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf05773, Pf07717, Pf18044, Pf21010" "90957" "ENSG00000163214" "DHX57" "A2RRC7; hsa:90957; Q53SI4; Q6P158; Q6P9G1; Q7Z6H3; Q8NG17; Q96M33" "" "" "0" "0" "1.037" "1.127" "1.131" "1.229" "1.122" "1.213" "1.229" "1.171" "1.222" "203.2" "210.6" "229.0" "229.9" "249.7" "228.0" "246.4" "249.7" "238.1" "248.3" "" "" "" "" "" "" "" "" "" "" "163.2" "152.0" "181.9" "154.0" "172.7" "171.1" "172.5" "182.3" "238.1" "201.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1754940364025586367" "False" "High" "IsMasterProtein" "Q9Y6R0" "Numb-like protein OS=Homo sapiens OX=9606 GN=NUMBL PE=1 SV=1" "0.000" "False" "19.149" "8" "4" "5" "2" "609" "64.9" "8.85" "19.85" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "" "Pf00640, Pf06311" "9253" "ENSG00000105245" "NUMBL" "hsa:9253; Q7Z4J9; Q9Y6R0" "" "Notch signaling; Neurogenesis regulation in the olfactory epithelium; Notch signaling pathway" "3" "0" "0.901" "0.812" "0.982" "0.952" "0.965" "0.831" "1.053" "1.048" "1.179" "42.4" "38.2" "34.4" "41.7" "40.4" "40.9" "35.2" "44.7" "44.4" "50.0" "" "" "" "" "" "" "" "" "" "" "34.1" "27.6" "27.4" "27.9" "27.9" "30.7" "24.7" "32.6" "44.4" "40.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4536078631798452952" "False" "High" "IsMasterProtein" "Q6P582" "Mitotic-spindle organizing protein 2A OS=Homo sapiens OX=9606 GN=MZT2A PE=1 SV=2" "0.000" "False" "19.134" "23" "2" "2" "1" "158" "16.2" "9.64" "10.14" "2" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "653784" "ENSG00000173272" "MZT2A" "hsa:653784; Q3SWV8; Q6P582; Q8WVB2" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2q21.1 copy number variation syndrome" "3" "0" "1.232" "1.003" "1.084" "1.099" "1.042" "1.261" "0.868" "0.980" "0.721" "27.4" "33.8" "27.5" "29.7" "30.1" "28.5" "34.5" "23.8" "26.8" "19.7" "" "" "" "" "" "" "" "" "" "" "22.0" "24.4" "21.8" "19.9" "20.8" "21.4" "24.2" "17.4" "26.8" "16.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4850932002920581345" "False" "High" "IsMasterProtein" "Q96GX5" "Serine/threonine-protein kinase greatwall OS=Homo sapiens OX=9606 GN=MASTL PE=1 SV=1" "0.000" "False" "19.130" "5" "4" "5" "3" "879" "97.3" "5.99" "18.26" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "84930" "ENSG00000120539" "MASTL" "hsa:84930; Q5T8D5; Q5T8D7; Q8NCD6; Q96GX5; Q96SJ5" "MASTL Facilitates Mitotic Progression" "" "1" "0" "0.999" "0.984" "0.937" "0.973" "1.073" "0.926" "1.155" "1.217" "0.983" "271.5" "271.2" "267.3" "254.4" "264.3" "291.4" "251.6" "313.6" "330.6" "266.8" "" "" "" "" "" "" "" "" "" "" "218.1" "195.7" "212.3" "170.4" "182.8" "218.6" "176.1" "229.0" "330.6" "217.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "745274347307830124" "False" "High" "IsMasterProtein" "Q9BX70" "BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=BTBD2 PE=1 SV=1" "0.000" "False" "19.113" "8" "4" "4" "3" "525" "55.9" "5.90" "14.46" "4" "developmental processes" "cytosol;other cell component" "" "Pf00651, Pf07707, Pf08005" "55643" "ENSG00000133243" "BTBD2" "hsa:55643; O60418; O75248; Q4VBZ1; Q6IAC5; Q7Z5W0; Q96SX8; Q9BX70; Q9NPS1; Q9NX81" "" "" "0" "0" "1.136" "1.023" "1.091" "1.081" "1.125" "1.039" "1.079" "1.161" "1.167" "115.9" "131.6" "118.5" "126.4" "125.3" "130.4" "120.4" "125.0" "134.6" "135.2" "" "" "" "" "" "" "" "" "" "" "93.1" "95.0" "94.1" "84.7" "86.6" "97.8" "84.3" "91.3" "134.6" "110.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4736314326613788604" "False" "High" "IsMasterProtein" "P62277" "Small ribosomal subunit protein uS15 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2" "0.000" "False" "19.103" "42" "6" "9" "6" "151" "17.2" "10.54" "21.41" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00312, Pf08069" "6207" "ENSG00000110700" "RPS13" "B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Selenocysteine synthesis; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.965" "1.035" "1.088" "1.051" "1.041" "0.982" "0.932" "1.070" "0.948" "492.7" "475.4" "509.9" "536.2" "518.0" "512.9" "483.6" "459.1" "527.1" "466.9" "" "" "" "" "" "" "" "" "" "" "395.7" "343.1" "405.0" "359.3" "358.3" "384.8" "338.6" "335.3" "527.1" "379.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1141422113329583141" "False" "High" "IsMasterProtein" "Q04446" "1,4-alpha-glucan-branching enzyme OS=Homo sapiens OX=9606 GN=GBE1 PE=1 SV=3" "0.000" "False" "19.100" "7" "5" "7" "5" "702" "80.4" "6.32" "22.59" "5" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00128, Pf02806, Pf02922" "2632" "ENSG00000114480" "GBE1" "B3KWV3; hsa:2632; Q04446; Q96EN0" "Glycogen synthesis; Glycogen storage disease type IV (GBE1)" "Glycogen synthesis and degradation; Disorders of galactose metabolism" "4" "0" "0.893" "0.929" "0.918" "0.943" "0.989" "0.975" "0.893" "0.918" "0.955" "726.1" "648.7" "674.3" "666.4" "684.9" "718.4" "708.2" "648.1" "666.4" "693.5" "" "" "" "" "" "" "" "" "" "" "583.2" "468.1" "535.6" "446.5" "473.7" "539.0" "495.8" "473.3" "666.4" "564.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835472215069796756" "False" "High" "IsMasterProtein" "Q9Y692" "Glucocorticoid modulatory element-binding protein 1 OS=Homo sapiens OX=9606 GN=GMEB1 PE=1 SV=2" "0.000" "False" "19.099" "10" "5" "5" "5" "573" "62.6" "4.83" "16.10" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01342" "10691" "ENSG00000162419" "GMEB1" "B1AT48; hsa:10691; Q9NWH1; Q9UKD0; Q9Y692" "" "2q37 copy number variation syndrome" "1" "0" "0.947" "0.791" "0.942" "0.744" "0.903" "0.844" "0.869" "0.812" "0.730" "50.2" "47.6" "39.7" "47.3" "37.4" "45.4" "42.4" "43.6" "40.8" "36.7" "" "" "" "" "" "" "" "" "" "" "40.3" "34.3" "31.5" "31.7" "25.9" "34.0" "29.7" "31.9" "40.8" "29.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1681183959761710458" "False" "High" "IsMasterProtein" "Q96G28" "Cilia- and flagella-associated protein 36 OS=Homo sapiens OX=9606 GN=CFAP36 PE=1 SV=2" "0.000" "False" "19.097" "16" "4" "5" "4" "342" "39.4" "4.97" "18.24" "4" "" "cytoskeleton;nucleus;other cell component" "" "Pf11527" "112942" "ENSG00000163001" "CFAP36" "hsa:112942; Q53SF0; Q53ST9; Q6UY34; Q96G28" "" "" "0" "0" "0.861" "0.983" "0.957" "0.906" "1.007" "0.994" "0.942" "0.971" "1.013" "425.6" "366.3" "418.4" "407.1" "385.7" "428.7" "423.1" "400.7" "413.0" "431.2" "" "" "" "" "" "" "" "" "" "" "341.8" "264.3" "332.4" "272.8" "266.7" "321.7" "296.2" "292.7" "413.0" "350.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3972038562420252503" "False" "High" "IsMasterProtein" "P61254" "Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "0.000" "False" "19.071" "34" "7" "8" "7" "145" "17.2" "10.55" "24.85" "7" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.875" "0.999" "0.985" "1.018" "1.022" "1.148" "1.003" "1.042" "1.004" "1011.7" "885.0" "1010.2" "996.7" "1029.8" "1033.6" "1161.9" "1015.0" "1054.5" "1015.6" "" "" "" "" "" "" "" "" "" "" "812.6" "638.6" "802.4" "667.8" "712.2" "775.5" "813.5" "741.2" "1054.5" "826.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5375440904508103637" "False" "High" "IsMasterProtein" "Q6ZSJ8" "Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=1 SV=2" "0.000" "False" "19.069" "23" "2" "4" "2" "110" "11.5" "6.73" "12.31" "2" "" "" "" "Pf15855" "127687" "ENSG00000197982" "C1orf122" "A2RQF4; E9PQ13; hsa:127687; Q56A71; Q6ZSJ8" "" "" "0" "0" "1.018" "1.010" "0.976" "1.055" "0.867" "0.867" "0.958" "0.904" "0.995" "252.0" "256.4" "254.5" "246.0" "265.9" "218.6" "218.5" "241.3" "227.8" "250.6" "" "" "" "" "" "" "" "" "" "" "202.4" "185.0" "202.1" "164.8" "183.9" "164.0" "153.0" "176.3" "227.8" "203.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587567595163417034" "False" "High" "IsMasterProtein" "Q9UIQ6" "Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3" "0.000" "False" "19.060" "6" "4" "5" "4" "1025" "117.3" "5.73" "12.59" "4" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "4012" "ENSG00000113441" "LNPEP" "hsa:4012; O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ6; Q9UIQ7" "Antigen processing: Ubiquitination & Proteasome degradation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Endosomal/Vacuolar pathway" "" "3" "0" "1.058" "1.014" "1.063" "1.110" "0.985" "1.123" "1.061" "1.032" "1.068" "501.9" "531.1" "508.7" "533.4" "557.3" "494.7" "563.5" "532.4" "517.8" "536.2" "" "" "" "" "" "" "" "" "" "" "403.2" "383.2" "404.1" "357.4" "385.5" "371.1" "394.5" "388.8" "517.8" "436.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-313217822058437387" "False" "High" "IsMasterProtein" "P55789" "FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens OX=9606 GN=GFER PE=1 SV=2" "0.000" "False" "19.051" "24" "3" "6" "3" "205" "23.4" "7.62" "18.11" "3" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf04777" "2671" "ENSG00000127554; ENSG00000291944" "GFER" "hsa:2671; P55789; Q53YM6; Q8TAH6; Q9H290; Q9UK40" "Mitochondrial protein import" "" "1" "0" "1.060" "1.053" "1.097" "1.079" "0.962" "1.126" "0.958" "1.027" "0.937" "130.0" "137.8" "136.9" "142.6" "140.2" "125.1" "146.4" "124.5" "133.5" "121.8" "" "" "" "" "" "" "" "" "" "" "104.4" "99.4" "108.7" "95.5" "97.0" "93.8" "102.5" "91.0" "133.5" "99.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122244859069195901" "False" "High" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "0.000" "False" "19.038" "16" "5" "10" "5" "304" "34.7" "8.53" "23.48" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "1.024" "0.944" "1.132" "1.133" "1.084" "1.013" "1.014" "0.963" "1.028" "226.0" "231.4" "213.4" "255.8" "256.1" "244.9" "228.9" "229.2" "217.6" "232.4" "" "" "" "" "" "" "" "" "" "" "181.5" "167.0" "169.5" "171.4" "177.1" "183.8" "160.2" "167.4" "217.6" "189.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4717651617297181896" "False" "High" "IsMasterProtein" "Q9UIC8" "Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2" "0.000" "False" "18.992" "14" "5" "7" "5" "334" "38.4" "6.04" "18.69" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04072" "51451" "ENSG00000205629" "LCMT1" "A6NL89; A8K770; hsa:51451; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9UIC8; Q9Y378" "Cyclin A/B1/B2 associated events during G2/M transition" "" "1" "0" "1.038" "1.009" "1.064" "1.032" "0.982" "0.971" "1.028" "1.015" "1.051" "677.5" "702.9" "683.3" "720.5" "699.4" "665.4" "658.0" "696.1" "687.6" "711.7" "" "" "" "" "" "" "" "" "" "" "544.1" "507.2" "542.8" "482.7" "483.7" "499.2" "460.7" "508.4" "687.6" "578.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6002449157154954042" "False" "High" "IsMasterProtein" "O60346" "PH domain leucine-rich repeat-containing protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PHLPP1 PE=1 SV=3" "0.000" "False" "18.951" "3" "4" "4" "4" "1717" "184.6" "6.28" "12.49" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00169, Pf00481, Pf00560, Pf13516, Pf13855" "23239" "ENSG00000081913" "PHLPP1" "A1A4F5; hsa:23239; O60346; Q641Q7; Q6P4C4; Q6PJI6; Q86TN6; Q96FK2; Q9NUY1" "Negative regulation of the PI3K/AKT network" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "3" "0" "0.944" "0.909" "0.992" "0.944" "0.980" "1.025" "0.917" "0.958" "0.927" "165.1" "156.0" "150.1" "163.8" "155.8" "161.8" "169.2" "151.5" "158.3" "153.1" "" "" "" "" "" "" "" "" "" "" "132.6" "112.5" "119.2" "109.7" "107.8" "121.4" "118.5" "110.6" "158.3" "124.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821659264702231707" "False" "High" "IsMasterProtein" "P13284" "Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens OX=9606 GN=IFI30 PE=1 SV=3" "0.000" "False" "18.951" "18" "3" "12" "3" "250" "27.9" "4.88" "22.78" "3" "other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03227" "10437" "ENSG00000216490" "IFI30" "hsa:10437; P13284; Q76MF9; Q8NEI4; Q8WU77; Q9UL08" "MHC class II antigen presentation; Interferon gamma signaling" "" "2" "0" "1.072" "1.061" "1.310" "1.234" "1.246" "1.406" "1.096" "1.118" "1.177" "236.5" "253.5" "251.0" "309.8" "291.8" "294.7" "332.5" "259.2" "264.4" "278.4" "" "" "" "" "" "" "" "" "" "" "190.0" "183.0" "199.4" "207.6" "201.8" "221.1" "232.8" "189.3" "264.4" "226.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043642977461230788" "False" "High" "IsMasterProtein" "Q92575" "UBX domain-containing protein 4 OS=Homo sapiens OX=9606 GN=UBXN4 PE=1 SV=2" "0.000" "False" "18.934" "5" "3" "4" "3" "508" "56.7" "6.38" "16.04" "3" "stress response" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf00789" "23190" "ENSG00000144224" "UBXN4" "A8K9W4; hsa:23190; Q4ZG56; Q8IYM5; Q92575" "" "" "0" "0" "0.946" "0.926" "0.911" "0.857" "0.967" "0.941" "0.937" "0.976" "0.916" "751.4" "711.0" "695.8" "684.6" "643.6" "726.4" "707.1" "704.1" "733.2" "688.4" "" "" "" "" "" "" "" "" "" "" "603.5" "513.1" "552.7" "458.7" "445.1" "545.0" "495.1" "514.2" "733.2" "559.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5997632050867013674" "False" "High" "IsMasterProtein" "Q9UGR2" "Zinc finger CCCH domain-containing protein 7B OS=Homo sapiens OX=9606 GN=ZC3H7B PE=1 SV=2" "0.000" "False" "18.925" "5" "5" "6" "5" "977" "109.8" "7.25" "18.35" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf13181" "23264" "ENSG00000100403" "ZC3H7B" "A7YY88; B2RCA4; hsa:23264; Q5TFX9; Q8TBT9; Q9H8B6; Q9UGQ9; Q9UGR0; Q9UGR1; Q9UGR2; Q9UK03; Q9UPW9" "" "" "0" "0" "0.964" "1.013" "1.022" "1.035" "1.083" "0.976" "1.056" "1.059" "1.068" "236.3" "227.8" "239.5" "241.5" "244.5" "255.9" "230.7" "249.5" "250.3" "252.4" "" "" "" "" "" "" "" "" "" "" "189.8" "164.4" "190.2" "161.8" "169.1" "192.0" "161.5" "182.2" "250.3" "205.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7187364612041296451" "False" "High" "IsMasterProtein" "Q96Q05" "Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2" "0.000" "False" "18.920" "3" "3" "4" "3" "1148" "128.4" "6.62" "15.28" "3" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf08626" "83696" "ENSG00000167632" "TRAPPC9" "hsa:83696; Q4VTT3; Q658K7; Q6P149; Q6ZQT3; Q7L5C4; Q86Y21; Q96Q05; Q96SL2; Q9BQA2" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "0.956" "0.943" "1.030" "0.980" "0.970" "0.963" "0.978" "0.940" "1.017" "556.8" "532.3" "525.0" "573.4" "545.8" "540.4" "536.3" "544.5" "523.4" "566.5" "" "" "" "" "" "" "" "" "" "" "447.2" "384.1" "417.0" "384.2" "377.5" "405.4" "375.5" "397.7" "523.4" "460.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1056370544189754053" "False" "High" "IsMasterProtein" "P28065" "Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2" "0.000" "False" "18.901" "23" "5" "8" "5" "219" "23.3" "5.03" "22.91" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5698" "ENSG00000239836; ENSG00000240065; ENSG00000240118; ENSG00000240508; ENSG00000242711; ENSG00000243067; ENSG00000243594; ENSG00000243958" "PSMB9" "B0V0T1; hsa:5698; P28065; Q16523; Q5JNW4" "Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Type II interferon signaling" "61" "0" "0.873" "0.909" "0.929" "0.975" "0.880" "0.963" "0.871" "0.896" "0.948" "851.0" "742.9" "773.4" "791.0" "830.0" "749.1" "819.4" "741.4" "762.3" "807.0" "" "" "" "" "" "" "" "" "" "" "683.5" "536.1" "614.3" "530.0" "574.1" "562.0" "573.7" "541.4" "762.3" "656.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561031833154832659" "False" "High" "IsMasterProtein" "O15379" "Histone deacetylase 3 OS=Homo sapiens OX=9606 GN=HDAC3 PE=1 SV=2" "0.000" "False" "18.877" "11" "5" "6" "4" "428" "48.8" "5.16" "17.90" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "8841" "ENSG00000171720" "HDAC3" "D3DQE1; hsa:8841; O15379; O43268; Q9UEI5; Q9UEV0" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "31" "0" "1.208" "1.250" "1.109" "1.218" "1.381" "1.252" "1.382" "1.277" "1.306" "70.3" "84.9" "87.8" "77.9" "85.6" "97.0" "88.0" "97.1" "89.7" "91.7" "" "" "" "" "" "" "" "" "" "" "56.4" "61.2" "69.7" "52.2" "59.2" "72.8" "61.6" "70.9" "89.7" "74.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8588470506095453677" "False" "High" "IsMasterProtein" "P21912" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" "0.000" "False" "18.873" "20" "6" "6" "6" "280" "31.6" "8.76" "21.88" "6" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf13085, Pf13534" "6390" "ENSG00000117118" "SDHB" "B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.949" "0.975" "1.030" "1.121" "1.072" "1.109" "0.972" "0.986" "1.046" "504.0" "478.5" "491.1" "519.0" "565.0" "540.4" "558.7" "489.9" "496.9" "527.0" "" "" "" "" "" "" "" "" "" "" "404.8" "345.3" "390.1" "347.8" "390.8" "405.5" "391.2" "357.8" "496.9" "428.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1882529908578060163" "False" "High" "IsMasterProtein" "Q9HAS0" "Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2" "0.000" "False" "18.838" "12" "5" "7" "5" "396" "44.6" "5.03" "20.60" "5" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf15053" "64149" "ENSG00000108666" "C17orf75" "hsa:64149; Q7Z2H4; Q9HAS0" "" "" "0" "0" "1.066" "1.048" "1.089" "1.071" "1.069" "1.017" "1.010" "1.110" "1.078" "358.9" "382.4" "376.0" "390.8" "384.5" "383.7" "365.0" "362.6" "398.3" "386.9" "" "" "" "" "" "" "" "" "" "" "288.3" "276.0" "298.7" "261.8" "265.9" "287.9" "255.5" "264.8" "398.3" "314.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7460825629413537855" "False" "High" "IsMasterProtein" "Q9BV40" "Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1" "0.000" "False" "18.832" "39" "4" "8" "4" "100" "11.4" "7.34" "25.69" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "8673" "ENSG00000118640" "VAMP8" "hsa:8673; O60625; Q53SP9; Q6IB09; Q9BV40" "Neutrophil degranulation; ER-Phagosome pathway; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "8" "0" "0.991" "0.951" "1.033" "1.102" "1.012" "1.079" "0.977" "1.018" "1.013" "882.2" "873.9" "838.6" "911.6" "972.4" "893.1" "951.8" "861.9" "898.5" "893.6" "" "" "" "" "" "" "" "" "" "" "708.6" "630.6" "666.1" "610.7" "672.5" "670.1" "666.4" "629.5" "898.5" "726.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8660233523405071508" "False" "High" "IsMasterProtein" "A0FGR8" "Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1" "0.000" "False" "18.816" "6" "4" "4" "4" "921" "102.3" "9.26" "12.64" "4" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00168, Pf17047" "57488" "ENSG00000117868" "ESYT2" "A0FGR8; A4D229; hsa:57488; Q69YJ2; Q6UKI4; Q6ZTU0; Q6ZVU1; Q9BQS0; Q9NW47; Q9ULJ2" "Glycosphingolipid transport" "" "1" "0" "1.066" "0.890" "0.965" "1.058" "1.018" "1.102" "0.969" "1.079" "0.976" "204.5" "217.9" "182.0" "197.4" "216.3" "208.2" "225.3" "198.2" "220.6" "199.6" "" "" "" "" "" "" "" "" "" "" "164.2" "157.2" "144.6" "132.2" "149.6" "156.2" "157.8" "144.8" "220.6" "162.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658645955564383119" "False" "High" "IsMasterProtein" "Q86Y82" "Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1" "0.000" "False" "18.815" "11" "2" "3" "2" "276" "31.6" "5.59" "11.31" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "23673" "ENSG00000117758" "STX12" "B1AJQ7; hsa:23673; O95564; Q86Y82" "" "" "0" "0" "1.166" "0.998" "1.090" "1.076" "1.017" "1.125" "0.938" "1.092" "1.017" "94.6" "110.3" "94.4" "103.1" "101.8" "96.2" "106.4" "88.7" "103.3" "96.3" "" "" "" "" "" "" "" "" "" "" "76.0" "79.6" "75.0" "69.1" "70.4" "72.2" "74.5" "64.8" "103.3" "78.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3337700356256422645" "False" "High" "IsMasterProtein" "Q86XR2" "Protein Niban 3 OS=Homo sapiens OX=9606 GN=NIBAN3 PE=1 SV=2" "0.000" "False" "18.782" "6" "4" "4" "4" "697" "77.4" "8.63" "15.98" "4" "" "" "" "" "199786" "ENSG00000167483" "NIBAN3" "B4DNU3; B4DVN7; hsa:199786; Q7Z6H6; Q86XR2; Q86XR3; Q86XR4; Q8TEQ3" "" "" "0" "0" "1.055" "0.983" "1.083" "1.088" "0.911" "0.974" "0.963" "1.038" "1.013" "428.0" "451.6" "420.6" "463.5" "465.7" "389.7" "416.9" "412.1" "444.2" "433.6" "" "" "" "" "" "" "" "" "" "" "343.7" "325.9" "334.1" "310.5" "322.1" "292.4" "291.9" "300.9" "444.2" "352.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2414902147837832753" "False" "High" "IsMasterProtein" "Q969R5" "Lethal(3)malignant brain tumor-like protein 2 OS=Homo sapiens OX=9606 GN=L3MBTL2 PE=1 SV=1" "0.000" "False" "18.780" "5" "3" "3" "3" "705" "79.1" "6.84" "12.44" "3" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf02820, Pf21319" "83746" "ENSG00000100395" "L3MBTL2" "hsa:83746; Q8TEN1; Q969R5; Q96SC4; Q9BQI2; Q9UGS4" "SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6" "" "2" "0" "1.029" "0.978" "0.880" "0.960" "1.022" "1.000" "1.057" "1.096" "1.013" "113.0" "116.3" "110.4" "99.4" "108.4" "115.5" "112.9" "119.4" "123.9" "114.5" "" "" "" "" "" "" "" "" "" "" "90.7" "83.9" "87.7" "66.6" "75.0" "86.7" "79.1" "87.2" "123.9" "93.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220085271204376127" "False" "High" "IsMasterProtein" "O95983" "Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1" "0.000" "False" "18.779" "23" "6" "6" "5" "291" "32.8" "5.34" "17.05" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "53615" "ENSG00000071655" "MBD3" "A8K4B7; D6W5Z2; hsa:53615; O95983; Q6PIL9; Q6PJZ9; Q86XF4" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in progeria" "7" "0" "1.007" "1.071" "1.210" "1.015" "0.966" "1.132" "1.128" "1.083" "1.175" "99.7" "100.4" "106.8" "120.7" "101.2" "96.3" "112.8" "112.4" "107.9" "117.1" "" "" "" "" "" "" "" "" "" "" "80.1" "72.4" "84.8" "80.8" "70.0" "72.3" "79.0" "82.1" "107.9" "95.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7917759671781486439" "False" "High" "IsMasterProtein" "Q13627" "Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2" "0.000" "False" "18.775" "5" "4" "5" "4" "763" "85.5" "8.75" "15.20" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1859" "ENSG00000157540" "DYRK1A" "hsa:1859; O60769; Q13627; Q92582; Q92810; Q9UNM5" "G0 and Early G1" "T cell receptor and co-stimulatory signaling; DYRK1A involvement regarding cell proliferation in brain development" "3" "0" "0.937" "0.967" "1.020" "0.962" "0.976" "0.902" "0.951" "0.989" "0.934" "596.8" "559.4" "577.0" "608.9" "573.9" "582.7" "538.1" "567.8" "590.4" "557.1" "" "" "" "" "" "" "" "" "" "" "479.3" "403.7" "458.4" "407.9" "396.9" "437.2" "376.8" "414.6" "590.4" "453.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248535501308075701" "False" "High" "IsMasterProtein" "P62879" "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Homo sapiens OX=9606 GN=GNB2 PE=1 SV=3" "0.000" "False" "18.771" "9" "3" "4" "3" "340" "37.3" "6.00" "15.62" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "2783" "ENSG00000172354" "GNB2" "B3KPU1; hsa:2783; P11016; P54312; P62879" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "36" "0" "0.942" "0.925" "0.923" "0.996" "0.997" "1.259" "0.998" "1.073" "0.952" "605.6" "570.5" "560.4" "558.9" "603.1" "603.5" "762.7" "604.4" "650.0" "576.2" "" "" "" "" "" "" "" "" "" "" "486.4" "411.7" "445.2" "374.5" "417.1" "452.8" "534.0" "441.4" "650.0" "468.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4679234799158284053" "False" "High" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "0.000" "False" "18.763" "20" "5" "7" "5" "285" "33.3" "5.86" "21.69" "5" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "0.953" "0.953" "1.087" "0.888" "1.065" "1.121" "1.058" "1.066" "1.017" "635.1" "605.0" "605.3" "690.4" "564.0" "676.1" "711.6" "671.7" "677.2" "645.8" "" "" "" "" "" "" "" "" "" "" "510.1" "436.6" "480.8" "462.6" "390.1" "507.3" "498.2" "490.5" "677.2" "525.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6390113821571435192" "False" "High" "IsMasterProtein" "Q9Y2H1" "Serine/threonine-protein kinase 38-like OS=Homo sapiens OX=9606 GN=STK38L PE=1 SV=3" "0.000" "False" "18.747" "10" "4" "5" "3" "464" "54.0" "6.81" "19.93" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00433" "23012" "ENSG00000211455" "STK38L" "A8K4U0; B4E3J8; hsa:23012; Q8TBX7; Q9Y2H1" "" "Hippo-YAP signaling; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "3" "0" "0.892" "0.903" "0.996" "0.963" "0.724" "0.904" "0.739" "0.718" "0.868" "59.7" "53.3" "54.0" "59.5" "57.5" "43.3" "54.0" "44.1" "42.9" "51.8" "" "" "" "" "" "" "" "" "" "" "48.0" "38.4" "42.9" "39.9" "39.8" "32.5" "37.8" "32.2" "42.9" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1034652218568526066" "False" "High" "IsMasterProtein" "Q66GS9" "Centrosomal protein of 135 kDa OS=Homo sapiens OX=9606 GN=CEP135 PE=1 SV=2" "0.000" "False" "18.725" "6" "7" "7" "6" "1140" "133.4" "6.21" "17.04" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "9662" "ENSG00000174799" "CEP135" "B2RMY0; hsa:9662; O75130; Q58F25; Q66GS9; Q9H8H7" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7491273576453503015" "False" "High" "IsMasterProtein" "Q9BYN0" "Sulfiredoxin-1 OS=Homo sapiens OX=9606 GN=SRXN1 PE=1 SV=2" "0.000" "False" "18.725" "28" "4" "4" "4" "137" "14.3" "8.19" "14.01" "4" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "" "140809" "ENSG00000271303" "SRXN1" "B2R543; hsa:140809; Q8NDM3; Q96AK6; Q9BYN0" "NFE2L2 regulating anti-oxidant/detoxification enzymes" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "4" "0" "1.003" "0.968" "1.004" "0.966" "1.078" "1.168" "1.098" "1.126" "1.057" "187.1" "187.6" "181.1" "187.8" "180.7" "201.7" "218.4" "205.5" "210.7" "197.8" "" "" "" "" "" "" "" "" "" "" "150.3" "135.3" "143.8" "125.9" "124.9" "151.3" "152.9" "150.1" "210.7" "160.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1811232654349558643" "False" "High" "IsMasterProtein" "P18846" "Cyclic AMP-dependent transcription factor ATF-1 OS=Homo sapiens OX=9606 GN=ATF1 PE=1 SV=2" "0.000" "False" "18.720" "18" "4" "8" "2" "271" "29.2" "8.37" "25.35" "4" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "466" "ENSG00000123268" "ATF1" "B4DRF9; hsa:466; P18846; P25168; Q9H4A8" "NGF-stimulated transcription; CREB phosphorylation" "Integrated cancer pathway; Androgen receptor network in prostate cancer; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; GDNF signaling; Serotonin receptor 4/6/7 and NR3C signaling" "9" "0" "0.867" "0.776" "1.016" "0.879" "1.055" "0.986" "1.089" "0.843" "0.832" "40.5" "35.1" "31.4" "41.1" "35.6" "42.7" "39.9" "44.1" "34.1" "33.7" "" "" "" "" "" "" "" "" "" "" "32.5" "25.3" "24.9" "27.6" "24.6" "32.0" "27.9" "32.2" "34.1" "27.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1890779364620067180" "False" "High" "IsMasterProtein" "Q96CD2" "Phosphopantothenoylcysteine decarboxylase OS=Homo sapiens OX=9606 GN=PPCDC PE=1 SV=2" "0.000" "False" "18.708" "23" "4" "5" "4" "204" "22.4" "6.10" "14.88" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02441" "60490" "ENSG00000138621" "PPCDC" "hsa:60490; Q96CD2; Q96SX0; Q9HC17" "Coenzyme A biosynthesis" "" "1" "0" "1.022" "1.028" "1.079" "1.009" "1.018" "1.108" "0.983" "0.940" "1.014" "326.7" "334.0" "335.8" "352.3" "329.8" "332.6" "361.9" "321.3" "307.2" "331.2" "" "" "" "" "" "" "" "" "" "" "262.4" "241.0" "266.7" "236.1" "228.1" "249.5" "253.4" "234.6" "307.2" "269.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4937271554403891889" "False" "High" "IsMasterProtein" "P16150" "Leukosialin OS=Homo sapiens OX=9606 GN=SPN PE=1 SV=1" "0.000" "False" "18.696" "14" "4" "4" "4" "400" "40.3" "5.10" "16.99" "4" "cell adhesion;cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "" "6693" "ENSG00000197471" "SPN" "A8K9B1; hsa:6693; P16150" "Basigin interactions" "16p11.2 proximal deletion syndrome" "3" "0" "0.944" "0.921" "1.115" "1.074" "1.034" "1.261" "1.058" "1.150" "1.073" "403.7" "381.2" "371.6" "450.2" "433.7" "417.6" "509.2" "427.1" "464.3" "433.1" "" "" "" "" "" "" "" "" "" "" "324.2" "275.1" "295.2" "301.6" "299.9" "313.3" "356.5" "311.9" "464.3" "352.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8204162643568548731" "False" "High" "IsMasterProtein" "Q9HD47" "Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1" "0.000" "False" "18.686" "30" "4" "4" "4" "186" "20.4" "4.94" "15.00" "4" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04603" "29098" "ENSG00000108961" "RANGRF" "D3DTR6; hsa:29098; Q68DI3; Q9BR68; Q9HD47; Q9HD48; Q9NRU9; Q9P001; Q9P0P2" "Phase 0 - rapid depolarisation" "" "1" "0" "1.068" "1.066" "1.054" "1.143" "1.133" "1.063" "0.995" "1.027" "1.164" "172.2" "184.0" "183.5" "181.6" "196.8" "195.0" "183.1" "171.3" "176.9" "200.5" "" "" "" "" "" "" "" "" "" "" "138.3" "132.8" "145.8" "121.7" "136.1" "146.3" "128.2" "125.1" "176.9" "163.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4971008711368622204" "False" "High" "IsMasterProtein" "Q9BVW5" "TIMELESS-interacting protein OS=Homo sapiens OX=9606 GN=TIPIN PE=1 SV=2" "0.000" "False" "18.651" "16" "5" "5" "5" "301" "34.5" "4.82" "18.93" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07962" "54962" "ENSG00000075131" "TIPIN" "B2CW64; hsa:54962; Q9BVW5; Q9NWZ6" "Processing of DNA double-strand break ends" "" "1" "0" "0.955" "0.912" "1.034" "0.910" "0.989" "1.111" "0.916" "1.036" "1.047" "218.7" "208.8" "199.5" "226.1" "199.0" "216.3" "243.1" "200.3" "226.5" "229.1" "" "" "" "" "" "" "" "" "" "" "175.7" "150.7" "158.4" "151.5" "137.6" "162.3" "170.2" "146.3" "226.5" "186.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3567158229513091577" "False" "High" "IsMasterProtein" "Q8NDX1" "PH and SEC7 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PSD4 PE=1 SV=2" "0.000" "False" "18.636" "6" "5" "5" "5" "1056" "116.2" "5.48" "15.49" "5" "other biological processes" "plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf01369, Pf15410" "23550" "ENSG00000125637" "PSD4" "A6NEG7; A8K1Y0; hsa:23550; O95621; Q4ZG34; Q6GPH8; Q8IYP4; Q8NDX1" "" "2q13 copy number variation syndrome" "1" "0" "1.226" "0.910" "1.356" "0.862" "0.820" "1.120" "0.797" "1.221" "1.400" "12.6" "15.5" "11.5" "17.1" "10.9" "10.3" "14.1" "10.0" "15.4" "17.7" "" "" "" "" "" "" "" "" "" "" "10.1" "11.2" "9.1" "11.5" "7.5" "7.8" "9.9" "7.3" "15.4" "14.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335740267375587213" "False" "High" "IsMasterProtein" "P09132" "Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3" "0.000" "False" "18.615" "20" "2" "2" "2" "144" "16.1" "9.85" "10.95" "2" "cell organization and biogenesis;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01922" "6728" "ENSG00000153037" "SRP19" "B2R4E9; D6RCQ5; hsa:6728; P09132; Q05D77; Q96FG6" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "0.950" "1.047" "1.207" "1.140" "1.028" "1.066" "1.073" "1.087" "1.119" "280.1" "266.1" "293.3" "338.1" "319.4" "288.1" "298.7" "300.5" "304.4" "313.5" "" "" "" "" "" "" "" "" "" "" "225.0" "192.0" "233.0" "226.5" "220.9" "216.1" "209.1" "219.5" "304.4" "255.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8032789585989089755" "False" "High" "IsMasterProtein" "Q9BYV9" "Transcription regulator protein BACH2 OS=Homo sapiens OX=9606 GN=BACH2 PE=1 SV=1" "0.000" "False" "18.613" "7" "6" "6" "6" "841" "92.5" "5.10" "16.12" "6" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "60468" "ENSG00000112182" "BACH2" "E1P518; hsa:60468; Q59H70; Q5T793; Q9BYV9; Q9NTS5" "" "Extrafollicular and follicular B cell activation by SARS-CoV-2" "1" "0" "1.048" "1.017" "1.137" "1.097" "1.036" "1.011" "1.045" "1.037" "1.064" "445.4" "466.9" "453.1" "506.3" "488.7" "461.6" "450.3" "465.4" "461.8" "473.9" "" "" "" "" "" "" "" "" "" "" "357.7" "336.9" "359.9" "339.2" "338.0" "346.3" "315.3" "339.9" "461.8" "385.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2665398799840712854" "False" "High" "IsMasterProtein" "Q5VWJ9" "Sorting nexin-30 OS=Homo sapiens OX=9606 GN=SNX30 PE=1 SV=1" "0.000" "False" "18.546" "9" "4" "4" "4" "437" "49.6" "5.35" "15.66" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf03114" "401548" "ENSG00000148158" "SNX30" "hsa:401548; Q5VWJ9" "" "" "0" "0" "0.987" "0.946" "0.981" "0.974" "0.986" "0.963" "0.953" "0.996" "1.029" "431.1" "425.7" "407.8" "423.0" "419.7" "424.9" "415.4" "410.6" "429.3" "443.8" "" "" "" "" "" "" "" "" "" "" "346.3" "307.2" "323.9" "283.4" "290.3" "318.8" "290.8" "299.9" "429.3" "360.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-60388765585118576" "False" "High" "IsMasterProtein" "Q9H875" "PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1" "0.000" "False" "18.545" "22" "4" "8" "4" "184" "21.0" "9.79" "24.89" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06658" "79706" "ENSG00000128563" "PRKRIP1" "B4DGM2; hsa:79706; Q8NDM6; Q96CF8; Q9H875" "mRNA Splicing - Major Pathway" "" "1" "0" "1.117" "1.148" "1.064" "1.026" "1.087" "1.109" "1.041" "1.027" "1.026" "548.0" "612.2" "629.2" "582.9" "562.5" "595.4" "607.6" "570.3" "562.6" "562.1" "" "" "" "" "" "" "" "" "" "" "440.1" "441.7" "499.8" "390.5" "389.0" "446.7" "425.4" "416.5" "562.6" "457.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1831448905794715132" "False" "High" "IsMasterProtein" "P84098" "Large ribosomal subunit protein eL19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1" "0.000" "False" "18.543" "21" "4" "5" "4" "196" "23.5" "11.47" "15.79" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01280" "6143" "ENSG00000108298" "RPL19" "B2R4K2; P14118; P22908; P84098; Q502Y6; Q7Z6E4" "Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.026" "1.109" "1.097" "0.945" "1.117" "1.144" "1.057" "1.018" "1.197" "279.4" "286.7" "309.9" "306.6" "264.1" "312.0" "319.5" "295.4" "284.6" "334.6" "" "" "" "" "" "" "" "" "" "" "224.4" "206.9" "246.2" "205.4" "182.6" "234.1" "223.7" "215.7" "284.6" "272.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8049844811418031107" "False" "High" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "0.000" "False" "18.540" "10" "2" "3" "2" "220" "25.4" "10.07" "12.42" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "tRNA processing in the nucleus" "" "1" "0" "0.869" "1.106" "1.029" "1.036" "0.948" "1.227" "1.079" "1.038" "0.905" "64.7" "56.2" "71.5" "66.6" "67.0" "61.4" "79.3" "69.8" "67.1" "58.6" "" "" "" "" "" "" "" "" "" "" "52.0" "40.6" "56.8" "44.6" "46.3" "46.0" "55.6" "51.0" "67.1" "47.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773428691670053213" "False" "High" "IsMasterProtein" "P62834" "Ras-related protein Rap-1A OS=Homo sapiens OX=9606 GN=RAP1A PE=1 SV=1" "0.000" "False" "18.538" "29" "5" "6" "1" "184" "21.0" "6.67" "19.18" "5" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5906" "ENSG00000116473" "RAP1A" "hsa:5906; P10113; P62834" "Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; DNA repair pathways, full network; GDNF signaling; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141936988023863748" "False" "High" "IsMasterProtein" "Q9NP61" "ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1" "0.000" "False" "18.533" "7" "3" "3" "3" "516" "56.9" "7.36" "12.37" "3" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "26286" "ENSG00000242247" "ARFGAP3" "E9PB03; hsa:26286; Q9BSC6; Q9H9J0; Q9NP61; Q9NT10; Q9NUP5; Q9Y4V3; Q9Y4V4" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; RHOG GTPase cycle" "Ciliary landscape" "5" "0" "0.993" "0.953" "0.960" "1.036" "1.017" "0.890" "0.940" "1.047" "0.986" "305.4" "303.4" "291.1" "293.3" "316.4" "310.5" "271.9" "287.1" "319.7" "301.1" "" "" "" "" "" "" "" "" "" "" "245.3" "218.9" "231.2" "196.5" "218.9" "233.0" "190.4" "209.7" "319.7" "244.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911938199932515837" "False" "High" "IsMasterProtein" "Q9NZQ3" "NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1" "0.000" "False" "18.527" "7" "5" "5" "5" "722" "78.9" "6.38" "14.84" "5" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00018, Pf09431" "51517" "ENSG00000213672" "NCKIPSD" "B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "" "3" "0" "1.021" "0.914" "1.048" "1.013" "1.000" "1.050" "1.035" "1.017" "1.023" "341.6" "348.7" "312.2" "357.9" "345.9" "341.7" "358.7" "353.4" "347.3" "349.5" "" "" "" "" "" "" "" "" "" "" "274.4" "251.6" "248.0" "239.8" "239.2" "256.4" "251.2" "258.1" "347.3" "284.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5410140500926118897" "False" "High" "IsMasterProtein" "Q96PU4" "E3 ubiquitin-protein ligase UHRF2 OS=Homo sapiens OX=9606 GN=UHRF2 PE=1 SV=1" "0.000" "False" "18.524" "8" "6" "6" "5" "802" "89.9" "8.21" "17.46" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "115426" "ENSG00000147854" "UHRF2" "hsa:115426; Q5VYR1; Q5VYR3; Q659C8; Q8TAG7; Q96PU4" "SUMOylation of transcription cofactors" "" "1" "0" "0.924" "0.979" "1.010" "0.985" "1.022" "0.930" "0.930" "0.935" "1.028" "412.6" "381.2" "404.1" "416.9" "406.5" "421.7" "384.0" "383.9" "385.7" "424.3" "" "" "" "" "" "" "" "" "" "" "331.4" "275.1" "321.0" "279.3" "281.2" "316.4" "268.8" "280.3" "385.7" "345.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6538585977691412019" "False" "High" "IsMasterProtein" "Q9BYB4" "Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2" "0.000" "False" "18.487" "12" "3" "4" "3" "327" "35.6" "7.97" "14.08" "3" "" "" "" "Pf00400" "54584" "ENSG00000185838" "GNB1L" "hsa:54584; Q9BYB4; Q9H2S2; Q9H4M4" "" "22q11.2 copy number variation syndrome" "1" "0" "1.098" "1.082" "1.116" "1.040" "1.091" "0.957" "1.058" "1.206" "1.072" "197.7" "217.2" "213.9" "220.6" "205.7" "215.7" "189.3" "209.2" "238.5" "211.9" "" "" "" "" "" "" "" "" "" "" "158.8" "156.7" "169.9" "147.8" "142.3" "161.9" "132.5" "152.8" "238.5" "172.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3279265676386753137" "False" "High" "IsMasterProtein" "Q9BXB4" "Oxysterol-binding protein-related protein 11 OS=Homo sapiens OX=9606 GN=OSBPL11 PE=1 SV=2" "0.000" "False" "18.480" "8" "6" "6" "5" "747" "83.6" "7.06" "18.54" "6" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114885" "ENSG00000144909" "OSBPL11" "A8K9I7; hsa:114885; Q9BXB4" "RHOH GTPase cycle" "" "1" "0" "0.996" "0.985" "1.126" "0.989" "1.011" "1.076" "0.997" "1.036" "1.019" "394.7" "393.0" "388.9" "444.5" "390.4" "399.1" "424.7" "393.6" "409.0" "402.3" "" "" "" "" "" "" "" "" "" "" "317.0" "283.6" "308.9" "297.8" "270.0" "299.4" "297.4" "287.5" "409.0" "327.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1137572445612648044" "False" "High" "IsMasterProtein" "Q7Z4L5" "Tetratricopeptide repeat protein 21B OS=Homo sapiens OX=9606 GN=TTC21B PE=1 SV=2" "0.000" "False" "18.461" "3" "3" "4" "3" "1316" "150.8" "6.96" "13.40" "3" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13176, Pf13181, Pf14559" "79809" "ENSG00000123607" "TTC21B" "A8MUZ3; Q3LIE4; Q53T84; Q6P4A1; Q6PIF5; Q7Z4L5; Q8NCN3; Q96MA4; Q9HAK8" "Intraflagellar transport; Hedgehog 'off' state" "Nephrotic syndrome; Ciliopathies; Bardet-Biedl syndrome" "5" "0" "1.086" "0.937" "1.246" "1.054" "1.037" "1.246" "1.317" "1.141" "1.116" "94.8" "103.0" "88.9" "118.2" "99.9" "98.3" "118.2" "124.9" "108.2" "105.9" "" "" "" "" "" "" "" "" "" "" "76.2" "74.3" "70.6" "79.2" "69.1" "73.8" "82.7" "91.2" "108.2" "86.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2332005078854859868" "False" "High" "IsMasterProtein" "Q9BWT6" "Meiotic nuclear division protein 1 homolog OS=Homo sapiens OX=9606 GN=MND1 PE=1 SV=1" "0.000" "False" "18.458" "22" "5" "5" "5" "205" "23.7" "8.19" "15.96" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism" "nucleus" "nucleic acid binding activity" "Pf03962, Pf18517" "84057" "ENSG00000121211" "MND1" "B2R5F9; hsa:84057; Q9BWT6" "Meiotic recombination" "Primary ovarian insufficiency" "2" "0" "1.106" "1.087" "1.061" "1.108" "1.117" "1.087" "1.111" "1.186" "1.127" "291.9" "322.9" "317.2" "309.8" "323.4" "326.1" "317.3" "324.3" "346.0" "328.9" "" "" "" "" "" "" "" "" "" "" "234.4" "233.0" "251.9" "207.6" "223.7" "244.6" "222.2" "236.8" "346.0" "267.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6736379060781022662" "False" "High" "IsMasterProtein" "P21399" "Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3" "0.000" "False" "18.449" "7" "4" "4" "4" "889" "98.3" "6.68" "14.24" "4" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "48" "ENSG00000122729" "ACO1" "D3DRK7; hsa:48; P21399; Q14652; Q5VZA7" "Iron uptake and transport" "Iron metabolism in placenta; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)" "3" "0" "0.988" "0.949" "1.052" "1.063" "0.906" "1.078" "0.880" "0.947" "0.976" "176.5" "174.3" "167.5" "185.6" "187.6" "160.0" "190.3" "155.3" "167.1" "172.2" "" "" "" "" "" "" "" "" "" "" "141.7" "125.8" "133.0" "124.4" "129.7" "120.0" "133.3" "113.4" "167.1" "140.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-577333653668623519" "False" "High" "IsMasterProtein" "Q9HAD4" "WD repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=WDR41 PE=1 SV=3" "0.000" "False" "18.437" "12" "5" "5" "5" "459" "51.7" "5.44" "16.22" "5" "other metabolic processes;other biological processes" "other cell component" "" "Pf00400" "55255" "ENSG00000164253" "WDR41" "B4DT55; hsa:55255; Q7Z792; Q8IWG3; Q8IXA9; Q8NDA7; Q9HAD4; Q9NV62" "" "" "0" "0" "1.069" "1.088" "1.096" "1.007" "1.008" "0.853" "0.944" "0.984" "1.036" "317.7" "339.6" "345.7" "348.1" "320.0" "320.3" "271.0" "300.0" "312.8" "329.1" "" "" "" "" "" "" "" "" "" "" "255.2" "245.0" "274.6" "233.2" "221.3" "240.3" "189.8" "219.1" "312.8" "267.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9101384525569952634" "False" "High" "IsMasterProtein" "Q9BZF1" "Oxysterol-binding protein-related protein 8 OS=Homo sapiens OX=9606 GN=OSBPL8 PE=1 SV=3" "0.000" "False" "18.421" "6" "5" "7" "5" "889" "101.1" "6.96" "22.32" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114882" "ENSG00000091039" "OSBPL8" "A8K1T2; E9PE66; E9PE68; hsa:114882; Q52LQ3; Q68D75; Q8WXP8; Q9BZF1; Q9P277" "Acyl chain remodelling of PS" "" "1" "0" "0.989" "0.937" "0.987" "1.011" "0.989" "1.002" "1.092" "1.140" "1.018" "616.9" "610.2" "578.0" "609.0" "623.6" "610.4" "618.0" "673.7" "703.5" "628.3" "" "" "" "" "" "" "" "" "" "" "495.5" "440.3" "459.1" "408.0" "431.3" "458.0" "432.7" "492.0" "703.5" "510.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703387660850171759" "False" "High" "IsMasterProtein" "O95900" "Pseudouridylate synthase TRUB2, mitochondrial OS=Homo sapiens OX=9606 GN=TRUB2 PE=1 SV=1" "0.000" "False" "18.419" "10" "3" "3" "3" "331" "36.7" "8.98" "12.92" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01509" "26995" "ENSG00000167112" "TRUB2" "B7Z7G5; hsa:26995; O95900" "" "" "0" "0" "1.069" "1.181" "1.191" "1.201" "1.112" "1.169" "1.089" "1.110" "1.093" "214.3" "229.0" "252.9" "255.3" "257.3" "238.3" "250.4" "233.4" "237.8" "234.2" "" "" "" "" "" "" "" "" "" "" "172.1" "165.2" "200.9" "171.0" "178.0" "178.8" "175.3" "170.4" "237.8" "190.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5442712666023189626" "False" "High" "IsMasterProtein" "O43251" "RNA binding protein fox-1 homolog 2 OS=Homo sapiens OX=9606 GN=RBFOX2 PE=1 SV=3" "0.000" "False" "18.418" "11" "2" "2" "2" "390" "41.3" "7.27" "10.49" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12414" "23543" "ENSG00000100320; ENSG00000277564" "RBFOX2" "A4F5G8; A8K5Z5; B0QYY8; B0QYY9; hsa:23543; O43251; Q0PRL5; Q0VH35; Q5TF71; Q6IC09; Q8TD00; Q8WYB1; Q96DZ6; Q96NL7; Q9UGW4; Q9UH33" "FGFR2 alternative splicing" "Mammalian disorder of sexual development" "2" "0" "1.132" "1.063" "1.092" "1.184" "0.967" "0.978" "0.992" "0.959" "0.948" "128.3" "145.3" "136.5" "140.2" "151.9" "124.1" "125.5" "127.3" "123.0" "121.7" "" "" "" "" "" "" "" "" "" "" "103.1" "104.8" "108.4" "93.9" "105.1" "93.1" "87.9" "93.0" "123.0" "98.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2806673757180566722" "False" "High" "IsMasterProtein" "P54709" "Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1" "0.000" "False" "18.413" "10" "2" "3" "2" "279" "31.5" "8.35" "11.63" "2" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00287" "483" "ENSG00000069849" "ATP1B3" "B7Z1N7; hsa:483; P54709" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases; Basigin interactions" "Calcium regulation in cardiac cells" "5" "0" "1.292" "1.148" "1.040" "1.347" "1.429" "1.501" "1.036" "1.210" "1.293" "43.5" "56.3" "50.0" "45.3" "58.6" "62.2" "65.3" "45.1" "52.7" "56.3" "" "" "" "" "" "" "" "" "" "" "35.0" "40.6" "39.7" "30.3" "40.6" "46.7" "45.7" "32.9" "52.7" "45.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2750317325017084074" "False" "High" "IsMasterProtein" "Q12962" "Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1" "0.000" "False" "18.410" "24" "3" "5" "3" "218" "21.7" "6.57" "18.27" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03540" "6881" "ENSG00000166337" "TAF10" "hsa:6881; O00703; Q12962; Q13175; Q6FH13" "HATs acetylate histones; Ub-specific processing proteases; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "" "11" "0" "1.285" "1.114" "1.165" "1.036" "1.057" "0.951" "1.107" "1.048" "0.989" "297.5" "382.4" "331.3" "346.6" "308.3" "314.3" "282.9" "329.3" "311.8" "294.3" "" "" "" "" "" "" "" "" "" "" "238.9" "275.9" "263.1" "232.2" "213.2" "235.8" "198.1" "240.5" "311.8" "239.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3039666916282587145" "False" "High" "IsMasterProtein" "Q562E7" "WD repeat-containing protein 81 OS=Homo sapiens OX=9606 GN=WDR81 PE=1 SV=2" "0.000" "False" "18.354" "2" "4" "5" "4" "1941" "211.6" "5.58" "14.98" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00400, Pf02138" "124997" "ENSG00000167716; ENSG00000276021" "WDR81" "B3KW16; B3KXU1; B7Z579; E9PHG7; hsa:124997; Q24JP6; Q562E7; Q8N277; Q8N3F3; Q8TEL1" "CDC42 GTPase cycle" "" "1" "0" "1.197" "1.087" "1.130" "1.165" "1.124" "1.098" "1.191" "1.182" "1.196" "232.4" "278.2" "252.6" "262.7" "270.7" "261.2" "255.2" "276.8" "274.9" "278.1" "" "" "" "" "" "" "" "" "" "" "186.7" "200.8" "200.6" "176.0" "187.2" "196.0" "178.7" "202.2" "274.9" "226.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1368746537246451603" "False" "High" "IsMasterProtein" "Q9Y2I8" "WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2" "0.000" "False" "18.348" "9" "5" "6" "5" "494" "54.6" "7.23" "15.42" "5" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "22884" "ENSG00000047056" "WDR37" "A8K976; D3DRQ7; hsa:22884; Q5SW03; Q8WVG2; Q9NTJ6; Q9Y2I8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2665594491149638353" "False" "High" "IsMasterProtein" "P12931" "Proto-oncogene tyrosine-protein kinase Src OS=Homo sapiens OX=9606 GN=SRC PE=1 SV=3" "0.000" "False" "18.327" "8" "5" "6" "2" "536" "59.8" "7.42" "21.47" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "6714" "ENSG00000197122; ENSG00000291971" "SRC" "E1P5V4; hsa:6714; P12931; Q76P87; Q86VB9; Q9H5A8" "G alpha (i) signalling events; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; PIP3 activates AKT signaling; Signaling by BRAF and RAF1 fusions; Regulation of RUNX3 expression and activity; RHOU GTPase cycle; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DCC mediated attractive signaling; Downstream signal transduction; Signaling by ERBB2; Nuclear signaling by ERBB4; RAF activation; GAB1 signalosome; MET activates PTK2 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; RUNX2 regulates osteoblast differentiation; Long-term potentiation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of commissural axon pathfinding by SLIT and ROBO; Netrin mediated repulsion signals; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Activated NTRK2 signals through FYN; Downregulation of ERBB4 signaling; Regulation of RUNX1 Expression and Activity; Activated NTRK3 signals through PI3K" "Androgen receptor signaling pathway; Angiogenesis; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Aryl hydrocarbon receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Robo4 and VEGF signaling pathways crosstalk; Fibrin complement receptor 3 signaling pathway; MET in type 1 papillary renal cell carcinoma; Acute viral myocarditis; NRF2-ARE regulation; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway" "90" "1" "1.042" "0.952" "1.099" "1.086" "1.056" "1.057" "1.145" "1.153" "1.044" "327.6" "341.3" "311.9" "360.2" "355.9" "345.9" "346.4" "375.1" "377.6" "341.9" "" "" "" "" "" "" "" "" "" "" "263.1" "246.3" "247.8" "241.3" "246.2" "259.5" "242.5" "274.0" "377.6" "278.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378421800270237029" "False" "High" "IsMasterProtein" "Q5TZA2" "Rootletin OS=Homo sapiens OX=9606 GN=CROCC PE=1 SV=2" "0.000" "False" "18.299" "2" "5" "10" "4" "2017" "228.3" "5.49" "24.95" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf15035" "9696" "ENSG00000058453" "CROCC" "hsa:9696; Q2VHY3; Q5TZA2; Q66GT7; Q7Z2L4; Q7Z5D7" "" "" "0" "0" "1.008" "0.928" "1.163" "1.075" "0.910" "1.093" "0.995" "0.905" "0.997" "108.8" "109.7" "100.9" "126.5" "117.0" "99.0" "118.9" "108.2" "98.4" "108.5" "" "" "" "" "" "" "" "" "" "" "87.4" "79.1" "80.2" "84.7" "80.9" "74.3" "83.2" "79.1" "98.4" "88.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291509197618805102" "False" "High" "IsMasterProtein" "Cont_Q3SZ57" "Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1" "0.000" "True" "18.295" "8" "6" "7" "5" "610" "68.5" "6.29" "20.93" "6" "other metabolic processes;developmental processes;signal transduction" "non-structural extracellular;other cell component" "other molecular function" "Pf00273" "506011" "ENSBIXG00000005150; ENSBTAG00000017131" "AFP" "A0A4W2DDK5; bta:506011; Q3SZ57" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "0.950" "0.734" "1.091" "0.751" "0.993" "1.348" "0.851" "0.855" "0.958" "309.2" "293.7" "226.9" "337.4" "232.1" "307.1" "416.8" "263.2" "264.3" "296.2" "" "" "" "" "" "" "" "" "" "" "248.4" "211.9" "180.2" "226.1" "160.5" "230.4" "291.8" "192.2" "264.3" "240.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1838412941252019118" "False" "High" "IsMasterProtein" "Q9Y530" "ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2" "0.000" "False" "18.290" "16" "2" "5" "2" "152" "17.0" "8.31" "18.99" "2" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf01661" "221443" "ENSG00000124596" "OARD1" "A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530" "" "" "0" "0" "1.044" "1.009" "1.025" "1.163" "1.003" "1.026" "1.076" "0.934" "1.075" "261.5" "272.9" "263.8" "268.0" "304.2" "262.2" "268.3" "281.4" "244.2" "281.1" "" "" "" "" "" "" "" "" "" "" "210.0" "196.9" "209.6" "179.5" "210.4" "196.7" "187.9" "205.5" "244.2" "228.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-32150545336103988" "False" "High" "IsMasterProtein" "Q14687" "Genetic suppressor element 1 OS=Homo sapiens OX=9606 GN=GSE1 PE=1 SV=3" "0.000" "False" "18.283" "4" "4" "4" "4" "1217" "136.1" "7.74" "15.52" "4" "" "" "" "Pf12540" "23199" "ENSG00000131149" "GSE1" "D3DUM4; hsa:23199; Q14687; Q8IY61; Q96GA4; Q9BW09" "" "" "0" "0" "0.879" "0.893" "1.100" "0.956" "0.940" "0.978" "1.042" "0.858" "0.889" "277.8" "244.1" "248.2" "305.7" "265.5" "261.0" "271.7" "289.5" "238.3" "247.0" "" "" "" "" "" "" "" "" "" "" "223.1" "176.1" "197.1" "204.8" "183.6" "195.9" "190.3" "211.5" "238.3" "200.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493401864324206702" "False" "High" "IsMasterProtein" "Q53S33" "BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1" "0.000" "False" "18.280" "33" "3" "5" "3" "107" "12.1" "9.64" "19.03" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf01722" "388962" "ENSG00000163170" "BOLA3" "G3XAB0; hsa:388962; Q53S33" "" "" "0" "0" "0.977" "1.013" "0.922" "0.897" "1.019" "0.826" "0.908" "0.979" "0.993" "397.0" "387.7" "402.1" "366.2" "356.2" "404.5" "327.8" "360.7" "388.6" "394.2" "" "" "" "" "" "" "" "" "" "" "318.9" "279.8" "319.4" "245.4" "246.3" "303.5" "229.5" "263.4" "388.6" "320.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1014508030414011044" "False" "High" "IsMasterProtein" "P62899" "Large ribosomal subunit protein eL31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "0.000" "False" "18.275" "30" "4" "6" "4" "125" "14.5" "10.54" "20.13" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.020" "1.106" "1.130" "1.144" "1.163" "1.245" "1.056" "1.211" "1.225" "397.7" "405.8" "440.0" "449.6" "455.2" "462.5" "495.3" "420.0" "481.7" "487.2" "" "" "" "" "" "" "" "" "" "" "319.5" "292.8" "349.5" "301.2" "314.8" "347.0" "346.8" "306.7" "481.7" "396.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4461868117343589472" "False" "High" "IsMasterProtein" "Q66K14" "TBC1 domain family member 9B OS=Homo sapiens OX=9606 GN=TBC1D9B PE=1 SV=3" "0.000" "False" "18.272" "4" "4" "5" "4" "1250" "140.4" "5.25" "15.73" "4" "" "other membranes" "enzyme regulator activity;other molecular function" "Pf00566, Pf02893" "23061" "ENSG00000197226; ENSG00000284400" "TBC1D9B" "D3DWQ5; D3DWQ6; hsa:23061; O75163; Q53EY0; Q66K14; Q6MZI2; Q96H49" "" "" "0" "0" "0.949" "0.963" "1.113" "1.032" "1.050" "0.945" "1.043" "1.047" "1.057" "264.5" "251.0" "254.8" "294.4" "273.1" "277.6" "250.0" "275.9" "277.1" "279.5" "" "" "" "" "" "" "" "" "" "" "212.4" "181.1" "202.4" "197.3" "188.9" "208.3" "175.0" "201.5" "277.1" "227.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1704471211926066966" "False" "High" "IsMasterProtein" "Q8TEM1" "Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3" "0.000" "False" "18.264" "2" "3" "4" "3" "1887" "205.0" "6.81" "16.03" "3" "transport" "other membranes;ER/Golgi;nucleus" "" "Pf02368" "23225" "ENSG00000132182" "NUP210" "A6NN56; hsa:23225; O94980; Q6NXG6; Q8NBJ1; Q8TEM1; Q9H6C8; Q9UFP3" "Nuclear Pore Complex (NPC) Disassembly; ISG15 antiviral mechanism; Regulation of HSF1-mediated heat shock response; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; HCMV Late Events; SUMOylation of RNA binding proteins; HCMV Early Events; Transcriptional regulation by small RNAs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "0.966" "1.015" "0.911" "1.002" "1.094" "0.932" "1.022" "1.082" "1.095" "141.2" "136.3" "143.3" "128.6" "141.4" "154.5" "131.6" "144.2" "152.7" "154.5" "" "" "" "" "" "" "" "" "" "" "113.4" "98.4" "113.9" "86.1" "97.8" "115.9" "92.1" "105.3" "152.7" "125.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441376780111574138" "False" "High" "IsMasterProtein" "Q96BS2" "Calcineurin B homologous protein 3 OS=Homo sapiens OX=9606 GN=TESC PE=1 SV=3" "0.000" "False" "18.219" "21" "4" "6" "4" "214" "24.7" "4.93" "19.72" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13405" "54997" "ENSG00000088992" "TESC" "F5H1Y5; hsa:54997; Q96BS2; Q9NWT9" "" "" "0" "0" "0.919" "0.912" "1.121" "1.100" "0.930" "1.057" "0.972" "1.073" "1.110" "153.6" "141.2" "140.1" "172.2" "169.0" "142.8" "162.3" "149.3" "164.8" "170.5" "" "" "" "" "" "" "" "" "" "" "123.4" "101.9" "111.3" "115.4" "116.9" "107.1" "113.6" "109.1" "164.8" "138.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7247108035044904633" "False" "High" "IsMasterProtein" "P62244" "Small ribosomal subunit protein uS8 OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "0.000" "False" "18.217" "36" "5" "6" "5" "130" "14.8" "10.13" "17.65" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.034" "1.372" "1.255" "1.195" "1.200" "1.165" "1.071" "1.187" "1.150" "457.5" "472.8" "627.7" "574.3" "546.8" "548.8" "532.9" "490.1" "542.8" "526.1" "" "" "" "" "" "" "" "" "" "" "367.4" "341.2" "498.6" "384.7" "378.2" "411.7" "373.1" "357.9" "542.8" "427.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494127544242029271" "False" "High" "IsMasterProtein" "P62249" "Small ribosomal subunit protein uS9 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "0.000" "False" "18.210" "34" "6" "10" "6" "146" "16.4" "10.21" "31.81" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; SARS-CoV-1 modulates host translation machinery; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "19" "0" "0.939" "1.236" "1.067" "1.056" "1.168" "1.140" "1.194" "1.109" "1.140" "677.1" "636.1" "836.6" "722.3" "715.2" "790.7" "771.8" "808.6" "751.2" "772.0" "" "" "" "" "" "" "" "" "" "" "543.8" "459.0" "664.6" "483.9" "494.7" "593.3" "540.4" "590.5" "751.2" "627.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5775237487534858758" "False" "High" "IsMasterProtein" "P62750" "Large ribosomal subunit protein uL23 OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "0.000" "False" "18.209" "25" "4" "10" "4" "156" "17.7" "10.45" "21.69" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.893" "1.043" "1.010" "0.967" "0.990" "1.031" "1.089" "1.041" "1.013" "859.7" "767.7" "896.6" "868.1" "831.3" "851.4" "886.4" "935.9" "895.1" "870.6" "" "" "" "" "" "" "" "" "" "" "690.5" "553.9" "712.2" "581.7" "574.9" "638.8" "620.6" "683.5" "895.1" "708.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1297378894876740813" "False" "High" "IsMasterProtein" "Q16854" "Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2" "0.000" "False" "18.181" "14" "4" "6" "4" "277" "32.0" "8.66" "22.25" "4" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01712" "1716" "ENSG00000114956" "DGUOK" "hsa:1716; P78532; Q16759; Q16854; Q4ZG09; Q7L1W9; Q96BC1" "Purine salvage" "Genetic causes of porto-sinusoidal vascular disease" "2" "0" "0.957" "0.992" "0.936" "0.954" "0.932" "0.908" "0.852" "0.913" "0.873" "788.4" "754.5" "782.4" "738.2" "751.7" "734.4" "716.2" "672.0" "720.0" "688.4" "" "" "" "" "" "" "" "" "" "" "633.2" "544.4" "621.5" "494.6" "519.9" "551.0" "501.4" "490.8" "720.0" "559.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1944436007343456073" "False" "High" "IsMasterProtein" "Q9H7B4" "Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens OX=9606 GN=SMYD3 PE=1 SV=4" "0.000" "False" "18.109" "14" "5" "8" "5" "428" "49.1" "7.25" "21.01" "5" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01753" "64754" "ENSG00000185420" "SMYD3" "A8K0P0; B1AN38; hsa:64754; Q86TL8; Q8N5Z6; Q96AI5; Q9H7B4" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "1.041" "1.031" "1.146" "1.074" "1.056" "1.039" "1.012" "0.996" "1.088" "634.0" "659.8" "653.8" "726.3" "680.6" "669.4" "658.6" "641.7" "631.2" "689.6" "" "" "" "" "" "" "" "" "" "" "509.2" "476.1" "519.4" "486.6" "470.7" "502.2" "461.1" "468.6" "631.2" "560.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3788247885213699411" "False" "High" "IsMasterProtein" "P04233" "HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3" "0.000" "False" "18.102" "7" "2" "3" "2" "296" "33.5" "8.44" "12.83" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf08831, Pf09307" "972" "ENSG00000019582" "CD74" "A8K7R1; B4DNE8; D3DQG3; D3DQG4; hsa:972; P04233; Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6" "MHC class II antigen presentation; Cell surface interactions at the vascular wall" "Macrophage markers" "3" "0" "1.285" "1.130" "1.307" "1.479" "1.272" "1.491" "1.452" "1.400" "1.273" "65.9" "84.7" "74.5" "86.1" "97.4" "83.8" "98.2" "95.7" "92.3" "83.9" "" "" "" "" "" "" "" "" "" "" "52.9" "61.1" "59.2" "57.7" "67.4" "62.9" "68.8" "69.9" "92.3" "68.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6961915596553006747" "False" "High" "IsMasterProtein" "Q9Y6J0" "Calcineurin-binding protein cabin-1 OS=Homo sapiens OX=9606 GN=CABIN1 PE=1 SV=1" "0.000" "False" "18.102" "3" "4" "4" "4" "2220" "246.2" "6.02" "13.33" "4" "cell organization and biogenesis;signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf09047" "23523" "ENSG00000099991" "CABIN1" "G5E9F3; hsa:23523; Q6PHY0; Q9Y460; Q9Y6J0" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Calcium mediated T-cell apoptosis involved in inclusion body myositis" "2" "0" "1.027" "1.126" "1.084" "1.099" "1.090" "1.160" "1.176" "1.125" "1.232" "276.6" "284.0" "311.4" "299.9" "304.1" "301.6" "321.0" "325.2" "311.2" "340.8" "" "" "" "" "" "" "" "" "" "" "222.2" "204.9" "247.3" "201.0" "210.3" "226.3" "224.7" "237.5" "311.2" "277.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3451849306749892991" "False" "High" "IsMasterProtein" "P49459" "Ubiquitin-conjugating enzyme E2 A OS=Homo sapiens OX=9606 GN=UBE2A PE=1 SV=2" "0.000" "False" "18.083" "24" "2" "2" "1" "152" "17.3" "5.15" "10.47" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7319" "ENSG00000077721" "UBE2A" "A6NFE9; A6NGR2; A6NMF5; B2R7R9; D3DWI1; hsa:7319; P49459; Q4TTG1; Q96FX4" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "" "3" "1" "0.893" "0.932" "0.837" "0.847" "0.990" "0.979" "0.872" "1.103" "1.007" "154.3" "137.8" "143.9" "129.3" "130.7" "152.8" "151.1" "134.6" "170.2" "155.4" "" "" "" "" "" "" "" "" "" "" "124.0" "99.4" "114.3" "86.6" "90.4" "114.7" "105.8" "98.3" "170.2" "126.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155528844813379728" "False" "High" "IsMasterProtein" "Q68CZ2" "Tensin-3 OS=Homo sapiens OX=9606 GN=TNS3 PE=1 SV=2" "0.000" "False" "18.082" "3" "5" "5" "5" "1445" "155.2" "6.81" "14.96" "5" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00017, Pf08416, Pf10409" "64759" "ENSG00000136205" "TNS3" "B2RNV1; hsa:64759; Q68CZ2; Q6IPQ2; Q8IZW7; Q8NAD0; Q96PE0; Q96S48" "MET interacts with TNS proteins" "" "1" "0" "1.234" "1.024" "1.097" "1.132" "1.189" "1.088" "1.189" "1.151" "1.131" "108.5" "133.8" "111.1" "119.0" "122.8" "128.9" "118.1" "129.0" "124.8" "122.7" "" "" "" "" "" "" "" "" "" "" "87.1" "96.6" "88.2" "79.8" "84.9" "96.7" "82.7" "94.2" "124.8" "99.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412599355076663570" "False" "High" "IsMasterProtein" "Q8WV92" "MIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MITD1 PE=1 SV=1" "0.000" "False" "18.082" "17" "3" "4" "3" "249" "29.3" "8.00" "14.50" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04212, Pf16565" "129531" "ENSG00000158411" "MITD1" "hsa:129531; Q69YV0; Q8WV92" "" "TAR syndrome" "1" "0" "1.187" "1.161" "1.195" "1.112" "1.104" "1.095" "1.033" "1.083" "1.206" "196.3" "233.1" "227.9" "234.5" "218.4" "216.7" "214.9" "202.8" "212.6" "236.8" "" "" "" "" "" "" "" "" "" "" "157.7" "168.2" "181.0" "157.1" "151.0" "162.6" "150.5" "148.1" "212.6" "192.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3386437626543326564" "False" "High" "IsMasterProtein" "Q9BWE0" "DNA-binding protein REPIN1 OS=Homo sapiens OX=9606 GN=REPIN1 PE=1 SV=1" "0.000" "False" "18.060" "11" "5" "7" "5" "567" "63.5" "9.98" "21.54" "5" "DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "29803" "ENSG00000214022" "REPIN1" "C9J3L7; D3DWZ1; hsa:29803; Q7LE03; Q9BUZ6; Q9BWE0; Q9NZH2; Q9UMP5" "" "" "0" "0" "0.887" "1.001" "1.260" "0.945" "1.199" "1.159" "1.062" "1.094" "1.092" "67.0" "59.4" "67.0" "84.4" "63.3" "80.3" "77.6" "71.1" "73.2" "73.2" "" "" "" "" "" "" "" "" "" "" "53.8" "42.9" "53.2" "56.5" "43.8" "60.3" "54.3" "51.9" "73.2" "59.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7850572796846009162" "False" "High" "IsMasterProtein" "P52435" "DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1" "0.000" "False" "18.037" "24" "3" "4" "3" "117" "13.3" "5.86" "14.34" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "5439" "ENSG00000005075" "POLR2J" "A5D6V8; hsa:5439; O43375; P52435" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.060" "1.113" "0.950" "0.995" "1.100" "0.968" "1.042" "1.018" "1.065" "570.2" "604.3" "634.5" "541.5" "567.6" "627.2" "551.8" "593.9" "580.3" "607.1" "" "" "" "" "" "" "" "" "" "" "458.0" "436.1" "504.0" "362.8" "392.6" "470.6" "386.4" "433.7" "580.3" "493.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4156627100779081460" "False" "High" "IsMasterProtein" "Q02446" "Transcription factor Sp4 OS=Homo sapiens OX=9606 GN=SP4 PE=1 SV=2" "0.000" "False" "18.027" "7" "2" "2" "2" "784" "81.9" "7.05" "10.07" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6671" "ENSG00000105866" "SP4" "hsa:6671; O60402; Q02446; Q32M52" "" "" "0" "0" "1.083" "1.118" "1.436" "1.388" "1.053" "1.620" "1.161" "1.191" "1.260" "12.7" "13.8" "14.2" "18.2" "17.6" "13.4" "20.6" "14.7" "15.1" "16.0" "" "" "" "" "" "" "" "" "" "" "10.2" "9.9" "11.3" "12.2" "12.2" "10.0" "14.4" "10.8" "15.1" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "592112739915171791" "False" "High" "IsMasterProtein" "Q8NCG7" "Diacylglycerol lipase-beta OS=Homo sapiens OX=9606 GN=DAGLB PE=1 SV=2" "0.000" "False" "18.003" "7" "4" "6" "4" "672" "73.7" "6.55" "16.91" "4" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf01764" "221955" "ENSG00000164535" "DAGLB" "A4D2P3; B3KV90; B4DQU0; hsa:221955; Q6PIX3; Q8N2N2; Q8N9S1; Q8NCG7; Q8TED3; Q8WXE6" "Arachidonate production from DAG" "Cannabinoid receptor signaling; ADHD and autism (ASD) linked metabolic pathways and SNP" "3" "0" "0.979" "1.083" "0.984" "0.976" "1.025" "0.995" "0.923" "1.049" "1.051" "249.3" "244.2" "269.9" "245.2" "243.2" "255.5" "248.0" "230.0" "261.6" "262.1" "" "" "" "" "" "" "" "" "" "" "200.2" "176.2" "214.4" "164.3" "168.2" "191.7" "173.6" "168.0" "261.6" "213.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968943538571685199" "False" "High" "IsMasterProtein" "Q96GC5" "Large ribosomal subunit protein mL48 OS=Homo sapiens OX=9606 GN=MRPL48 PE=1 SV=2" "0.000" "False" "17.987" "16" "3" "5" "3" "212" "23.9" "8.98" "19.03" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "51642" "ENSG00000175581" "MRPL48" "B4DN34; hsa:51642; Q49AK7; Q4U2Q4; Q96GC5; Q9P091; Q9Y5J0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.975" "0.908" "0.984" "0.995" "1.039" "1.025" "0.987" "0.990" "1.030" "229.7" "224.0" "208.6" "226.0" "228.5" "238.7" "235.5" "226.6" "227.3" "236.6" "" "" "" "" "" "" "" "" "" "" "184.5" "161.6" "165.7" "151.4" "158.0" "179.1" "164.9" "165.5" "227.3" "192.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969170579020640520" "False" "High" "IsMasterProtein" "A6NKF1" "SAC3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAC3D1 PE=1 SV=2" "0.000" "False" "17.981" "11" "3" "3" "3" "404" "43.5" "8.69" "12.71" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf03399" "" "" "SAC3D1" "A6NKF1; A8MX08; Q99773" "" "" "0" "0" "1.123" "1.181" "1.228" "0.964" "1.120" "1.229" "1.086" "1.064" "1.241" "92.1" "103.4" "108.7" "113.1" "88.7" "103.1" "113.2" "100.0" "98.0" "114.3" "" "" "" "" "" "" "" "" "" "" "74.0" "74.6" "86.4" "75.8" "61.4" "77.4" "79.3" "73.0" "98.0" "93.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3047103662304523242" "False" "High" "IsMasterProtein" "Q9ULD9" "Zinc finger protein 608 OS=Homo sapiens OX=9606 GN=ZNF608 PE=1 SV=4" "0.000" "False" "17.978" "3" "4" "4" "4" "1512" "162.1" "8.79" "12.26" "4" "other biological processes" "nucleus" "other molecular function" "" "57507" "ENSG00000168916" "ZNF608" "A7E2W9; hsa:57507; Q3SYM6; Q68D12; Q8IY05; Q9ULD9; Q9Y5A1" "" "" "0" "0" "0.929" "1.072" "1.170" "0.978" "1.050" "0.862" "0.966" "0.958" "1.114" "87.1" "80.9" "93.4" "101.9" "85.1" "91.4" "75.1" "84.1" "83.4" "97.0" "" "" "" "" "" "" "" "" "" "" "70.0" "58.4" "74.2" "68.3" "58.9" "68.6" "52.6" "61.4" "83.4" "78.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447255440292633936" "False" "High" "IsMasterProtein" "Q92625" "Ankyrin repeat and SAM domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ANKS1A PE=1 SV=4" "0.000" "False" "17.932" "5" "4" "4" "4" "1134" "123.0" "6.38" "14.60" "4" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00023, Pf00536, Pf00640" "23294" "ENSG00000064999" "ANKS1A" "A2RUC1; B4DQW8; hsa:23294; Q5JYI9; Q5SYR2; Q86WQ7; Q92625" "" "" "0" "0" "0.998" "1.051" "1.085" "0.964" "0.948" "1.020" "0.993" "0.959" "0.979" "181.1" "180.8" "190.3" "196.6" "174.7" "171.8" "184.7" "179.9" "173.7" "177.4" "" "" "" "" "" "" "" "" "" "" "145.5" "130.5" "151.2" "131.7" "120.8" "128.9" "129.4" "131.4" "173.7" "144.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-626678755710490294" "False" "High" "IsMasterProtein" "O14593" "DNA-binding protein RFXANK OS=Homo sapiens OX=9606 GN=RFXANK PE=1 SV=2" "0.000" "False" "17.922" "21" "4" "4" "4" "260" "28.1" "4.55" "13.89" "4" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023" "8625" "ENSG00000064490" "RFXANK" "hsa:8625; O14593; O95839; Q24JQ1; Q6FGA8" "" "" "0" "0" "1.179" "1.084" "1.467" "1.178" "1.141" "1.287" "0.950" "1.121" "1.152" "82.0" "96.7" "88.9" "120.3" "96.6" "93.6" "105.6" "77.9" "91.9" "94.5" "" "" "" "" "" "" "" "" "" "" "65.9" "69.8" "70.6" "80.6" "66.8" "70.2" "73.9" "56.9" "91.9" "76.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7801299591553380074" "False" "High" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "0.000" "False" "17.909" "17" "3" "8" "3" "156" "18.0" "8.21" "23.90" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing; 3q29 copy number variation syndrome" "29" "0" "0.984" "0.973" "0.936" "1.047" "1.050" "1.006" "1.005" "1.004" "0.972" "932.5" "917.8" "907.6" "873.0" "976.1" "979.1" "938.5" "937.2" "936.5" "906.4" "" "" "" "" "" "" "" "" "" "" "749.0" "662.3" "720.9" "584.9" "675.1" "734.6" "657.1" "684.4" "936.5" "737.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-615574855873468037" "False" "High" "IsMasterProtein" "O75928" "E3 SUMO-protein ligase PIAS2 OS=Homo sapiens OX=9606 GN=PIAS2 PE=1 SV=3" "0.000" "False" "17.904" "7" "4" "4" "3" "621" "68.2" "7.52" "13.68" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02891, Pf14324" "9063" "ENSG00000078043" "PIAS2" "O75927; O75928; Q96BT5; Q96KE3" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "Androgen receptor signaling pathway; TGF-beta signaling pathway" "3" "1" "1.064" "0.956" "1.142" "1.092" "1.011" "1.000" "0.995" "1.011" "1.024" "326.1" "347.0" "311.9" "372.5" "356.1" "329.6" "326.3" "324.5" "329.7" "333.9" "" "" "" "" "" "" "" "" "" "" "261.9" "250.4" "247.7" "249.5" "246.3" "247.3" "228.4" "237.0" "329.7" "271.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8192519440703409270" "False" "High" "IsMasterProtein" "Q8NB37" "Glutamine amidotransferase-like class 1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATD1 PE=1 SV=1" "0.000" "False" "17.898" "19" "3" "4" "3" "220" "23.3" "6.61" "16.53" "3" "other metabolic processes" "other cell component" "other molecular function" "" "347862" "ENSG00000177225" "GATD1" "B7ZKW5; hsa:347862; Q2NL76; Q6ZQY0; Q8NAE0; Q8NB37" "" "" "0" "0" "1.101" "1.250" "1.326" "1.393" "1.045" "1.322" "1.712" "1.026" "1.162" "27.7" "30.4" "34.6" "36.7" "38.5" "28.9" "36.6" "47.3" "28.4" "32.1" "" "" "" "" "" "" "" "" "" "" "22.2" "22.0" "27.5" "24.6" "26.6" "21.7" "25.6" "34.6" "28.4" "26.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842107794335973179" "False" "High" "IsMasterProtein" "P15336" "Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens OX=9606 GN=ATF2 PE=1 SV=4" "0.000" "False" "17.873" "10" "6" "7" "2" "505" "54.5" "7.88" "23.17" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "1386" "ENSG00000115966" "ATF2" "A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5; hsa:1386; P15336; Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; Q96JT8" "NGF-stimulated transcription; Heme signaling; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; HATs acetylate histones; Activation of the AP-1 family of transcription factors; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Energy metabolism; IL-1 signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Myometrial relaxation and contraction pathways; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; DNA IR-double strand breaks and cellular response via ATM; Ethanol effects on histone modifications; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; 10q11.21q11.23 copy number variation syndrome; T-cell receptor signaling pathway" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357414389544456501" "False" "High" "IsMasterProtein" "P55212" "Caspase-6 OS=Homo sapiens OX=9606 GN=CASP6 PE=1 SV=2" "0.000" "False" "17.836" "17" "5" "5" "4" "293" "33.3" "6.93" "16.36" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656" "839" "ENSG00000138794" "CASP6" "hsa:839; P55212; Q9BQE7" "TP53 Regulates Transcription of Caspase Activators and Caspases; Caspase-mediated cleavage of cytoskeletal proteins; Breakdown of the nuclear lamina" "Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Acute viral myocarditis" "10" "0" "1.042" "1.000" "0.960" "1.023" "1.060" "1.107" "1.041" "1.244" "1.009" "192.9" "201.0" "192.9" "185.2" "197.4" "204.4" "213.5" "200.8" "239.9" "194.7" "" "" "" "" "" "" "" "" "" "" "154.9" "145.0" "153.2" "124.1" "136.5" "153.4" "149.5" "146.6" "239.9" "158.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4471823552801457794" "False" "High" "IsMasterProtein" "Q9GZN1" "Actin-related protein 6 OS=Homo sapiens OX=9606 GN=ACTR6 PE=1 SV=1" "0.000" "False" "17.814" "15" "4" "4" "4" "396" "45.8" "5.03" "13.35" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00022" "64431" "ENSG00000075089" "ACTR6" "B3KW37; B4DLG9; hsa:64431; Q53GH2; Q9BY39; Q9GZN1; Q9H8H6" "" "" "0" "0" "1.120" "1.005" "1.101" "1.093" "1.020" "1.061" "1.092" "1.031" "1.110" "86.2" "96.5" "86.6" "94.9" "94.2" "87.9" "91.5" "94.1" "88.9" "95.7" "" "" "" "" "" "" "" "" "" "" "69.2" "69.6" "68.8" "63.5" "65.2" "66.0" "64.0" "68.7" "88.9" "77.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5140965250815444674" "False" "High" "IsMasterProtein" "Q9ULJ6" "Zinc finger MIZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZMIZ1 PE=1 SV=3" "0.000" "False" "17.804" "4" "4" "4" "2" "1067" "115.4" "7.46" "16.42" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02891, Pf18028" "57178" "ENSG00000108175" "ZMIZ1" "hsa:57178; Q5JSH9; Q7Z7E6; Q9ULJ6" "" "Androgen receptor signaling pathway" "1" "1" "1.011" "0.955" "1.046" "1.119" "0.977" "1.041" "1.138" "1.040" "1.001" "487.3" "492.7" "465.4" "510.0" "545.1" "475.9" "507.2" "554.8" "506.8" "487.6" "" "" "" "" "" "" "" "" "" "" "391.4" "355.6" "369.7" "341.7" "377.0" "357.1" "355.1" "405.2" "506.8" "396.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4398789072412591486" "False" "High" "IsMasterProtein" "Q14249" "Endonuclease G, mitochondrial OS=Homo sapiens OX=9606 GN=ENDOG PE=1 SV=4" "0.000" "False" "17.796" "12" "3" "4" "3" "297" "32.6" "9.50" "12.62" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01223" "2021" "ENSG00000167136" "ENDOG" "hsa:2021; Q14249; Q5T281; Q9BSP2" "" "Nanomaterial induced apoptosis; Acute viral myocarditis" "2" "0" "1.028" "0.999" "1.204" "0.975" "1.156" "0.996" "1.150" "0.936" "0.897" "28.2" "29.0" "28.2" "33.9" "27.5" "32.6" "28.1" "32.4" "26.4" "25.3" "" "" "" "" "" "" "" "" "" "" "22.6" "20.9" "22.4" "22.7" "19.0" "24.4" "19.7" "23.7" "26.4" "20.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728784246141405942" "False" "High" "IsMasterProtein" "P09543" "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" "0.000" "False" "17.792" "12" "5" "6" "5" "421" "47.5" "9.07" "19.63" "5" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf05881, Pf13671" "1267" "ENSG00000173786" "CNP" "hsa:1267; P09543" "" "Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Cell lineage map for neuronal differentiation" "5" "0" "1.038" "0.939" "1.012" "1.023" "1.029" "1.195" "1.059" "1.126" "1.162" "425.3" "441.6" "399.3" "430.6" "435.0" "437.5" "508.3" "450.5" "478.9" "494.0" "" "" "" "" "" "" "" "" "" "" "341.6" "318.6" "317.2" "288.5" "300.9" "328.3" "355.9" "329.0" "478.9" "401.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5021864284547303722" "False" "High" "IsMasterProtein" "Q96GD4" "Aurora kinase B OS=Homo sapiens OX=9606 GN=AURKB PE=1 SV=3" "0.000" "False" "17.782" "16" "5" "5" "4" "344" "39.3" "9.29" "14.64" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9212" "ENSG00000178999" "AURKB" "B4DNM4; C7G533; C7G534; C7G535; D3DTR4; hsa:9212; J9JID1; O14630; O60446; O95083; Q96DV5; Q96GD4; Q9UQ46" "Regulation of TP53 Activity through Phosphorylation; RHO GTPases Activate Formins; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of MECP2 expression and activity" "Microtubule cytoskeleton regulation; ATM signaling in development and disease" "12" "0" "1.210" "1.171" "1.159" "1.232" "1.226" "1.256" "1.212" "1.114" "1.238" "237.3" "287.1" "277.8" "275.0" "292.3" "290.9" "298.0" "287.7" "264.3" "293.7" "" "" "" "" "" "" "" "" "" "" "190.6" "207.1" "220.6" "184.3" "202.1" "218.3" "208.7" "210.1" "264.3" "238.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7708170732071910709" "False" "High" "IsMasterProtein" "O96013" "Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1" "0.000" "False" "17.754" "8" "5" "6" "5" "591" "64.0" "9.73" "18.07" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00786" "10298" "ENSG00000130669" "PAK4" "B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8" "RHOG GTPase cycle; RAC2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle" "Integrin-mediated cell adhesion; Focal adhesion; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway" "25" "0" "1.076" "1.133" "1.332" "1.052" "1.142" "1.087" "0.993" "1.182" "1.189" "91.2" "98.1" "103.3" "121.4" "95.9" "104.1" "99.1" "90.5" "107.7" "108.4" "" "" "" "" "" "" "" "" "" "" "73.2" "70.8" "82.1" "81.4" "66.3" "78.1" "69.4" "66.1" "107.7" "88.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7909778503156322818" "False" "High" "IsMasterProtein" "Q96J02" "E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2" "0.000" "False" "17.719" "7" "5" "6" "5" "903" "102.7" "6.30" "20.62" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf00397, Pf00632" "83737" "ENSG00000078747" "ITCH" "A6NEW4; B4E234; E1P5P3; F5H217; hsa:83737; O43584; Q5QP37; Q5TEL0; Q96F66; Q96J02; Q9BY75; Q9H451; Q9H4U5" "Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Regulation of necroptotic cell death; NOD1/2 Signaling Pathway; Activated NOTCH1 Transmits Signal to the Nucleus; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Downregulation of ERBB4 signaling" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; 10q11.21q11.23 copy number variation syndrome; Notch signaling pathway" "16" "0" "1.004" "0.830" "1.018" "1.051" "0.934" "0.908" "1.086" "0.958" "1.107" "128.1" "128.7" "106.4" "130.5" "134.7" "119.6" "116.3" "139.2" "122.7" "141.9" "" "" "" "" "" "" "" "" "" "" "102.9" "92.8" "84.5" "87.4" "93.1" "89.8" "81.4" "101.7" "122.7" "115.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8981469479003528624" "False" "High" "IsMasterProtein" "Q9BZE1" "Large ribosomal subunit protein mL37 OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "0.000" "False" "17.718" "12" "5" "5" "5" "423" "48.1" "8.59" "15.83" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.825" "0.975" "1.010" "0.879" "0.971" "0.910" "0.962" "0.945" "0.923" "174.7" "144.0" "170.3" "176.4" "153.5" "169.6" "158.9" "168.1" "165.0" "161.2" "" "" "" "" "" "" "" "" "" "" "140.3" "103.9" "135.3" "118.2" "106.2" "127.2" "111.3" "122.8" "165.0" "131.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691038781667592311" "False" "High" "IsMasterProtein" "O94864" "STAGA complex 65 subunit gamma OS=Homo sapiens OX=9606 GN=SUPT7L PE=1 SV=1" "0.000" "False" "17.713" "13" "5" "5" "5" "414" "46.2" "5.12" "16.07" "5" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07524" "9913" "ENSG00000119760" "SUPT7L" "B4E3W3; hsa:9913; O94864; Q6IB21; Q9H2T6" "HATs acetylate histones" "" "1" "0" "0.951" "1.024" "1.058" "0.976" "1.080" "0.977" "0.972" "1.043" "1.005" "481.6" "457.9" "493.3" "509.7" "470.0" "520.0" "470.4" "468.0" "502.3" "483.8" "" "" "" "" "" "" "" "" "" "" "386.8" "330.4" "391.9" "341.5" "325.0" "390.1" "329.4" "341.7" "502.3" "393.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8715917564772373095" "False" "High" "IsMasterProtein" "Q9C0B7" "Transport and Golgi organization protein 6 homolog OS=Homo sapiens OX=9606 GN=TANGO6 PE=1 SV=2" "0.000" "False" "17.695" "6" "6" "7" "6" "1094" "120.7" "6.11" "18.20" "6" "transport" "other membranes" "" "Pf10304, Pf10363" "79613" "ENSG00000103047" "TANGO6" "hsa:79613; Q569F9; Q9C0B7; Q9H9K1" "" "" "0" "0" "1.357" "1.088" "1.072" "1.175" "1.298" "1.208" "1.063" "1.251" "1.045" "84.8" "115.1" "92.2" "90.9" "99.6" "110.1" "102.4" "90.2" "106.0" "88.6" "" "" "" "" "" "" "" "" "" "" "68.1" "83.0" "73.3" "60.9" "68.9" "82.6" "71.7" "65.9" "106.0" "72.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7040769112947432832" "False" "High" "IsMasterProtein" "Q96EY1" "DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2" "0.000" "False" "17.664" "10" "4" "7" "4" "480" "52.5" "9.26" "18.90" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00226, Pf00684, Pf01556" "9093" "ENSG00000103423; ENSG00000276726" "DNAJA3" "B2RAJ5; B4DI33; E7ES32; hsa:9093; O75472; Q8WUJ6; Q8WXJ3; Q96D76; Q96EY1; Q96IV1; Q9NYH8" "" "" "0" "0" "1.058" "1.031" "1.094" "1.095" "1.015" "1.066" "1.058" "1.038" "1.118" "396.9" "419.9" "409.2" "434.1" "434.6" "402.7" "423.1" "419.9" "411.8" "443.8" "" "" "" "" "" "" "" "" "" "" "318.8" "303.0" "325.0" "290.8" "300.6" "302.1" "296.3" "306.6" "411.8" "360.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4493911830020970266" "False" "High" "IsMasterProtein" "Q9BQE9" "B-cell CLL/lymphoma 7 protein family member B OS=Homo sapiens OX=9606 GN=BCL7B PE=1 SV=1" "0.000" "False" "17.637" "28" "4" "4" "2" "202" "22.2" "4.75" "11.86" "4" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf04714" "9275" "ENSG00000106635" "BCL7B" "A8K226; C9JWD3; D3DXF0; hsa:9275; O43769; Q13845; Q6ZW75; Q9BQE9" "" "7q11.23 copy number variation syndrome" "1" "0" "0.613" "0.807" "1.366" "0.735" "0.941" "0.521" "0.693" "0.932" "0.800" "18.4" "11.3" "14.8" "25.1" "13.5" "17.3" "9.6" "12.8" "17.2" "14.7" "" "" "" "" "" "" "" "" "" "" "14.8" "8.1" "11.8" "16.8" "9.3" "13.0" "6.7" "9.3" "17.2" "12.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575582902092764945" "False" "High" "IsMasterProtein" "Q9NQA3" "WAS protein family homolog 6 OS=Homo sapiens OX=9606 GN=WASH6P PE=1 SV=3" "0.000" "False" "17.633" "13" "5" "5" "1" "447" "48.0" "5.67" "17.36" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH6P" "A6NGF1; Q8N305; Q9NQA3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "High" "1" "" "-7768622532908684431" "False" "High" "IsMasterProtein" "P26842" "CD27 antigen OS=Homo sapiens OX=9606 GN=CD27 PE=1 SV=2" "0.000" "False" "17.618" "14" "3" "3" "3" "260" "29.1" "7.64" "13.09" "3" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf00020" "939" "ENSG00000139193" "CD27" "B2RDZ0; hsa:939; P26842" "TNFs bind their physiological receptors" "" "1" "0" "1.042" "0.916" "0.896" "1.113" "1.082" "1.129" "1.009" "1.188" "1.112" "183.0" "190.7" "167.6" "163.9" "203.6" "197.9" "206.6" "184.5" "217.4" "203.4" "" "" "" "" "" "" "" "" "" "" "147.0" "137.6" "133.2" "109.8" "140.8" "148.5" "144.6" "134.8" "217.4" "165.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4229859227879041997" "False" "High" "IsMasterProtein" "P16278" "Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2" "0.000" "False" "17.610" "4" "2" "3" "2" "677" "76.0" "6.57" "10.91" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01301, Pf21317, Pf21467" "2720" "ENSG00000170266" "GLB1" "B2R7H8; B7Z6B0; hsa:2720; P16278; P16279" "Neutrophil degranulation; HS-GAG degradation; Sialic acid metabolism; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective NEU1 causes sialidosis; MPS IV - Morquio syndrome B" "Ectoderm differentiation; Degradation pathway of sphingolipids, including diseases; Ciliary landscape; Glycosaminoglycan degradation; Sphingolipid metabolism in senescence" "12" "0" "1.071" "0.905" "1.005" "0.979" "0.991" "0.925" "1.017" "0.976" "0.934" "202.0" "216.3" "182.8" "202.9" "197.8" "200.1" "186.8" "205.4" "197.1" "188.7" "" "" "" "" "" "" "" "" "" "" "162.2" "156.1" "145.2" "136.0" "136.8" "150.2" "130.8" "150.0" "197.1" "153.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5713044218766232811" "False" "High" "IsMasterProtein" "Q9NXR7" "BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2" "0.000" "False" "17.598" "11" "4" "5" "4" "383" "43.5" "5.81" "17.58" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06113" "9577" "ENSG00000158019" "BABAM2" "A8K4X1; D6W562; D6W563; hsa:9577; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; Q9NXR7" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "1.012" "1.048" "1.092" "1.078" "1.050" "1.067" "1.059" "1.066" "1.023" "560.9" "567.7" "587.9" "612.3" "604.8" "589.2" "598.6" "594.0" "598.2" "573.8" "" "" "" "" "" "" "" "" "" "" "450.5" "409.7" "467.0" "410.2" "418.3" "442.1" "419.1" "433.8" "598.2" "466.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7927368921331951811" "False" "High" "IsMasterProtein" "Cont_O46375" "Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1" "0.000" "True" "17.597" "22" "3" "6" "3" "147" "15.7" "6.30" "19.20" "3" "other metabolic processes;signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00576" "102267525; 104980319; 109577967; 280948" "ENSBGRG00000022634; ENSBIXG00000008920; ENSBIXG00005017301; ENSBTAG00000010991" "TTR" "A0A4W2BU20; A0A6B0QTW8; A0A6P3GKP7; A0A6P5DX06; A0A8B9YDR1; bbis:104980319; biu:109577967; bom:102267525; bta:280948; O46375; Q3SZ91" "Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "" "3" "0" "0.962" "0.799" "0.976" "0.821" "0.916" "1.485" "0.915" "0.891" "0.988" "231.9" "223.1" "185.3" "226.3" "190.4" "212.4" "344.3" "212.1" "206.5" "229.1" "" "" "" "" "" "" "" "" "" "" "186.2" "161.0" "147.2" "151.6" "131.7" "159.4" "241.1" "154.9" "206.5" "186.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5057287332675180047" "False" "High" "IsMasterProtein" "P25963" "NF-kappa-B inhibitor alpha OS=Homo sapiens OX=9606 GN=NFKBIA PE=1 SV=1" "0.000" "False" "17.586" "15" "4" "5" "4" "317" "35.6" "4.68" "18.26" "4" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00023" "4792" "ENSG00000100906" "NFKBIA" "B2R8L6; hsa:4792; P25963" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; SARS-CoV-1 activates/modulates innate immune responses; SUMOylation of immune response proteins" "Nucleotide-binding oligomerization domain (NOD) pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; NO/cGMP/PKG mediated neuroprotection; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Burn wound healing; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Th17 cell differentiation pathway; GDNF signaling; 2q37 copy number variation syndrome; Comprehensive IL-17A signaling; IL-26 signaling pathways; Affected pathways in Duchenne muscular dystrophy; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "63" "0" "0.931" "0.879" "0.941" "0.980" "0.971" "0.957" "0.924" "1.015" "1.010" "375.5" "349.6" "330.0" "353.4" "367.9" "364.8" "359.2" "347.0" "381.2" "379.0" "" "" "" "" "" "" "" "" "" "" "301.6" "252.3" "262.1" "236.8" "254.4" "273.7" "251.5" "253.4" "381.2" "308.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3247337186477247949" "False" "High" "IsMasterProtein" "Q9UQR1" "Zinc finger protein 148 OS=Homo sapiens OX=9606 GN=ZNF148 PE=1 SV=2" "0.000" "False" "17.582" "9" "6" "6" "6" "794" "88.9" "6.48" "20.40" "6" "stress response;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7707" "ENSG00000163848" "ZNF148" "D3DN27; O00389; O43591; Q58EY5; Q6PJ98; Q9UQR1" "" "" "0" "0" "0.889" "0.953" "0.940" "0.996" "0.982" "1.035" "1.058" "1.010" "0.957" "256.9" "228.4" "244.8" "241.5" "255.9" "252.4" "265.8" "271.6" "259.4" "245.9" "" "" "" "" "" "" "" "" "" "" "206.3" "164.8" "194.5" "161.8" "177.0" "189.3" "186.1" "198.4" "259.4" "200.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8597337933688242360" "False" "High" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3B PE=1 SV=2" "0.000" "False" "17.578" "26" "4" "15" "2" "136" "15.3" "11.27" "51.66" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Chromatin modifications during the maternal to zygotic transition (MZT); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Amyloid fiber formation; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; Meiotic recombination; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation" "36" "2" "0.958" "1.007" "1.098" "0.977" "0.988" "1.147" "1.066" "1.083" "1.068" "1118.9" "1072.1" "1126.3" "1228.6" "1093.1" "1105.9" "1283.1" "1192.4" "1211.8" "1194.9" "" "" "" "" "" "" "" "" "" "" "898.7" "773.6" "894.7" "823.2" "756.0" "829.7" "898.3" "870.8" "1211.8" "971.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1676018771169478995" "False" "High" "IsMasterProtein" "O60293" "Zinc finger C3H1 domain-containing protein OS=Homo sapiens OX=9606 GN=ZFC3H1 PE=1 SV=3" "0.000" "False" "17.559" "2" "4" "5" "4" "1989" "226.2" "8.13" "9.42" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10650" "196441" "ENSG00000133858" "ZFC3H1" "hsa:196441; O60293; Q6GMU1; Q6P2S9; Q6ZV36; Q96BE7" "" "" "0" "0" "1.048" "1.000" "1.080" "1.081" "1.073" "1.085" "1.002" "1.043" "1.021" "511.4" "535.9" "511.5" "552.3" "552.7" "548.9" "554.6" "512.2" "533.2" "522.2" "" "" "" "" "" "" "" "" "" "" "410.7" "386.7" "406.3" "370.0" "382.3" "411.8" "388.3" "374.1" "533.2" "424.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119048535094086908" "False" "High" "IsMasterProtein" "P82912" "Small ribosomal subunit protein uS11m OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" "0.000" "False" "17.545" "16" "2" "2" "2" "194" "20.6" "10.81" "8.94" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00411" "64963" "ENSG00000181991" "MRPS11" "B2RD52; hsa:64963; P82912; Q969D7; Q96GI3; Q9BYC3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.056" "1.086" "1.033" "0.767" "1.128" "1.109" "1.120" "1.048" "0.984" "46.3" "48.9" "50.3" "47.8" "35.5" "52.2" "51.4" "51.9" "48.5" "45.6" "" "" "" "" "" "" "" "" "" "" "37.2" "35.3" "39.9" "32.0" "24.6" "39.2" "36.0" "37.9" "48.5" "37.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6137891794897938593" "False" "High" "IsMasterProtein" "Q8NEF9" "Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1" "0.000" "False" "17.541" "15" "7" "10" "7" "429" "48.6" "9.58" "20.85" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09073" "153443" "ENSG00000151304" "SRFBP1" "hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2" "" "" "0" "0" "1.045" "1.002" "1.047" "0.990" "1.003" "1.013" "1.047" "0.974" "0.999" "518.3" "541.8" "519.4" "542.9" "513.3" "519.6" "525.2" "542.5" "505.0" "517.8" "" "" "" "" "" "" "" "" "" "" "416.3" "391.0" "412.5" "363.8" "355.0" "389.9" "367.7" "396.2" "505.0" "421.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6226740505465900925" "False" "High" "IsMasterProtein" "Q08170" "Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2" "0.000" "False" "17.540" "10" "5" "5" "4" "494" "56.6" "11.52" "13.25" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6429" "ENSG00000116350" "SRSF4" "hsa:6429; Q08170; Q5VXP1; Q9BUA4; Q9UEB5" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "1" "0.878" "0.886" "0.979" "1.024" "1.166" "1.133" "1.065" "1.066" "1.092" "155.7" "136.7" "137.9" "152.4" "159.4" "181.5" "176.4" "165.8" "165.9" "170.0" "" "" "" "" "" "" "" "" "" "" "125.0" "98.7" "109.5" "102.1" "110.2" "136.2" "123.5" "121.1" "165.9" "138.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7880695163940437874" "False" "High" "IsMasterProtein" "Q9Y580" "RNA-binding protein 7 OS=Homo sapiens OX=9606 GN=RBM7 PE=1 SV=1" "0.000" "False" "17.518" "15" "5" "8" "5" "266" "30.5" "9.57" "21.91" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "10179" "ENSG00000076053" "RBM7" "B2R6K8; hsa:10179; Q9NUT4; Q9Y580" "mRNA Splicing - Major Pathway" "" "1" "0" "0.949" "0.997" "0.912" "0.914" "0.927" "0.881" "0.958" "0.871" "0.895" "455.6" "432.3" "454.1" "415.5" "416.5" "422.3" "401.4" "436.6" "396.7" "408.0" "" "" "" "" "" "" "" "" "" "" "366.0" "312.0" "360.7" "278.4" "288.1" "316.8" "281.1" "318.8" "396.7" "331.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6666677363642983444" "False" "High" "IsMasterProtein" "O75182" "Paired amphipathic helix protein Sin3b OS=Homo sapiens OX=9606 GN=SIN3B PE=1 SV=2" "0.000" "False" "17.503" "3" "4" "4" "4" "1162" "133.0" "6.93" "12.46" "4" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf02671, Pf08295, Pf16879" "23309" "ENSG00000127511" "SIN3B" "hsa:23309; O75182; Q2NL91; Q68GC2; Q6P4B8; Q8TB34; Q9BSC8" "NoRC negatively regulates rRNA expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "" "2" "0" "1.005" "0.885" "1.047" "0.996" "0.907" "1.027" "1.055" "0.966" "1.016" "258.9" "260.1" "229.1" "271.2" "257.8" "234.7" "265.8" "273.1" "250.1" "263.0" "" "" "" "" "" "" "" "" "" "" "208.0" "187.7" "182.0" "181.7" "178.3" "176.1" "186.1" "199.4" "250.1" "213.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229408047793123568" "False" "High" "IsMasterProtein" "O75155" "Cullin-associated NEDD8-dissociated protein 2 OS=Homo sapiens OX=9606 GN=CAND2 PE=1 SV=3" "0.000" "False" "17.501" "4" "6" "7" "3" "1236" "135.2" "5.68" "16.86" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08623" "23066" "ENSG00000144712" "CAND2" "B9EGM9; E9KL24; hsa:23066; O75155" "" "" "0" "0" "1.269" "1.077" "1.294" "0.987" "1.111" "0.981" "1.119" "1.318" "1.270" "66.9" "85.0" "72.1" "86.6" "66.0" "74.4" "65.7" "74.9" "88.3" "85.0" "" "" "" "" "" "" "" "" "" "" "53.8" "61.3" "57.2" "58.0" "45.7" "55.8" "46.0" "54.7" "88.3" "69.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2809797377402095157" "False" "High" "IsMasterProtein" "P42785" "Lysosomal Pro-X carboxypeptidase OS=Homo sapiens OX=9606 GN=PRCP PE=1 SV=1" "0.000" "False" "17.498" "10" "4" "4" "4" "496" "55.8" "7.21" "12.71" "4" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "5547" "ENSG00000137509" "PRCP" "A8MU24; B2R7B7; B3KRK5; B5BU34; hsa:5547; P42785" "Neutrophil degranulation; Intrinsic Pathway of Fibrin Clot Formation" "" "2" "0" "1.020" "0.917" "1.037" "1.126" "1.064" "1.130" "1.006" "1.020" "0.992" "300.3" "306.3" "275.4" "311.4" "338.1" "319.4" "339.2" "302.0" "306.2" "297.9" "" "" "" "" "" "" "" "" "" "" "241.2" "221.0" "218.8" "208.6" "233.8" "239.6" "237.5" "220.5" "306.2" "242.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8109670193418590883" "False" "High" "IsMasterProtein" "O14641" "Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1" "0.000" "False" "17.493" "6" "4" "4" "3" "736" "78.9" "6.02" "13.43" "4" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1856" "ENSG00000004975" "DVL2" "D3DTN3; hsa:1856; O14641; Q53XM0" "RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "29" "1" "1.166" "1.121" "1.273" "1.079" "1.129" "1.215" "1.299" "1.219" "1.075" "182.7" "212.9" "204.7" "232.5" "197.1" "206.3" "222.0" "237.3" "222.7" "196.4" "" "" "" "" "" "" "" "" "" "" "146.7" "153.7" "162.6" "155.8" "136.3" "154.8" "155.5" "173.3" "222.7" "159.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5357467251583528977" "False" "High" "IsMasterProtein" "Q49AR2" "UPF0489 protein C5orf22 OS=Homo sapiens OX=9606 GN=C5orf22 PE=1 SV=2" "0.000" "False" "17.491" "12" "3" "3" "3" "442" "49.9" "4.78" "8.91" "3" "" "" "" "Pf12640" "55322" "ENSG00000082213" "C5orf22" "hsa:55322; Q49AR2; Q8ND28; Q8WU61; Q9NUR1" "" "" "0" "0" "1.297" "1.258" "1.003" "0.993" "1.316" "1.088" "0.955" "1.089" "1.050" "31.6" "41.0" "39.8" "31.7" "31.4" "41.6" "34.4" "30.2" "34.4" "33.2" "" "" "" "" "" "" "" "" "" "" "25.4" "29.6" "31.6" "21.2" "21.7" "31.2" "24.1" "22.0" "34.4" "27.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6666030451106529783" "False" "High" "IsMasterProtein" "Q9NRY2" "SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1" "0.000" "False" "17.469" "21" "2" "3" "2" "104" "11.4" "9.25" "11.53" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf15925" "58493" "ENSG00000148153" "INIP" "hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090" "" "" "0" "0" "1.112" "0.993" "1.575" "1.017" "0.859" "1.377" "1.027" "0.896" "1.077" "264.0" "293.5" "262.3" "415.8" "268.5" "226.7" "363.5" "271.1" "236.6" "284.4" "" "" "" "" "" "" "" "" "" "" "212.1" "211.8" "208.3" "278.6" "185.7" "170.1" "254.5" "198.0" "236.6" "231.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3213067895580761470" "False" "High" "IsMasterProtein" "Q96CU9" "FAD-dependent oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FOXRED1 PE=1 SV=2" "0.000" "False" "17.463" "13" "4" "4" "4" "486" "53.8" "7.78" "13.51" "4" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01266" "55572" "ENSG00000110074" "FOXRED1" "B3KN84; B4DHU2; hsa:55572; Q71MG0; Q96CU9; Q9BU39; Q9UKY9" "" "" "0" "0" "1.147" "0.964" "1.081" "1.037" "1.009" "1.042" "1.030" "1.152" "1.104" "383.5" "439.9" "369.6" "414.6" "397.7" "387.1" "399.8" "394.8" "441.7" "423.4" "" "" "" "" "" "" "" "" "" "" "308.0" "317.4" "293.6" "277.8" "275.1" "290.4" "279.9" "288.3" "441.7" "344.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7498907094133803237" "False" "High" "IsMasterProtein" "A4D1P6" "WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2" "0.000" "False" "17.452" "5" "4" "4" "4" "747" "83.3" "6.58" "14.50" "4" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00400, Pf12894" "29062" "ENSG00000105875" "WDR91" "A4D1P6; A6NK54; C9JMI4; hsa:29062; Q6FI65; Q6MZQ1; Q6P4I1; Q96AE5; Q96G63; Q9H062; Q9H9B6; Q9NVG7; Q9NZY6" "CDC42 GTPase cycle" "" "1" "0" "0.993" "0.944" "0.949" "1.059" "1.026" "1.091" "1.033" "1.078" "1.066" "402.4" "399.7" "380.0" "382.0" "426.0" "413.0" "439.0" "415.7" "433.9" "428.8" "" "" "" "" "" "" "" "" "" "" "323.2" "288.4" "301.9" "256.0" "294.6" "309.9" "307.4" "303.6" "433.9" "348.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4299442073717893558" "False" "High" "IsMasterProtein" "Q9Y6A4" "Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1" "0.000" "False" "17.445" "19" "4" "5" "4" "193" "22.8" "9.76" "16.00" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf05018" "29105" "ENSG00000070761" "CFAP20" "hsa:29105; Q9Y6A4" "" "" "0" "0" "0.890" "1.274" "0.801" "0.974" "1.164" "0.815" "1.024" "1.113" "0.937" "91.2" "81.2" "116.1" "73.0" "88.7" "106.1" "74.3" "93.4" "101.4" "85.4" "" "" "" "" "" "" "" "" "" "" "73.2" "58.6" "92.2" "48.9" "61.4" "79.6" "52.0" "68.2" "101.4" "69.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1113653796691851863" "False" "High" "IsMasterProtein" "Q86X83" "COMM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=COMMD2 PE=1 SV=2" "0.000" "False" "17.432" "32" "5" "5" "5" "199" "22.7" "6.73" "13.34" "5" "" "other cell component" "" "Pf07258" "51122" "ENSG00000114744" "COMMD2" "hsa:51122; Q561V4; Q86X83; Q9H3L5; Q9Y5V1" "Neddylation" "" "1" "0" "0.987" "0.910" "0.982" "1.041" "1.083" "0.926" "0.886" "0.952" "0.962" "262.0" "258.5" "238.4" "257.4" "272.7" "283.9" "242.6" "232.2" "249.4" "252.0" "" "" "" "" "" "" "" "" "" "" "210.4" "186.5" "189.4" "172.4" "188.6" "213.0" "169.9" "169.6" "249.4" "204.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527749598789379160" "False" "High" "IsMasterProtein" "O75570" "Peptide chain release factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1 PE=1 SV=2" "0.000" "False" "17.430" "8" "3" "3" "3" "445" "52.3" "8.50" "12.17" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf00472, Pf03462" "9617" "ENSG00000120662" "MTRF1" "B4DG01; hsa:9617; O75570; Q5T6Y5; Q8IUQ6" "" "" "0" "0" "0.955" "0.973" "0.973" "1.009" "1.074" "0.913" "0.980" "1.014" "1.076" "225.0" "214.8" "218.8" "218.8" "227.1" "241.6" "205.3" "220.5" "228.1" "242.2" "" "" "" "" "" "" "" "" "" "" "180.7" "155.0" "173.8" "146.6" "157.1" "181.3" "143.8" "161.1" "228.1" "197.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3157784244312675539" "False" "High" "IsMasterProtein" "Q9UKD2" "mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2" "0.000" "False" "17.425" "21" "5" "8" "5" "239" "27.5" "8.29" "23.16" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00466, Pf17777" "51154" "ENSG00000053372" "MRTO4" "B3KNB3; hsa:51154; Q5TG55; Q96SS6; Q9BPV9; Q9UKD2" "" "" "0" "0" "1.096" "1.202" "1.160" "1.252" "1.234" "1.248" "1.251" "1.171" "1.206" "480.8" "527.0" "577.7" "557.7" "602.1" "593.1" "600.2" "601.3" "562.8" "579.7" "" "" "" "" "" "" "" "" "" "" "386.1" "380.3" "458.9" "373.6" "416.4" "445.0" "420.2" "439.1" "562.8" "471.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656538987652310722" "False" "High" "IsMasterProtein" "Q86X29" "Lipolysis-stimulated lipoprotein receptor OS=Homo sapiens OX=9606 GN=LSR PE=1 SV=4" "0.000" "False" "17.401" "7" "4" "5" "4" "649" "71.4" "7.97" "14.77" "4" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "" "Pf05624" "51599" "ENSG00000105699" "LSR" "A6NDW3; B4DKL4; E9PHD4; hsa:51599; O00112; O00426; Q6ZT80; Q86X29; Q8NBM0; Q9BT33; Q9UQL3" "LDL clearance; VLDL clearance" "" "2" "0" "1.043" "0.899" "1.068" "0.977" "1.079" "1.113" "1.069" "1.115" "1.090" "348.4" "363.4" "313.2" "372.0" "340.5" "375.9" "387.7" "372.4" "388.4" "379.9" "" "" "" "" "" "" "" "" "" "" "279.8" "262.2" "248.8" "249.2" "235.5" "282.1" "271.4" "271.9" "388.4" "308.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6384522747761550778" "False" "High" "IsMasterProtein" "Q9NUP7" "tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens OX=9606 GN=TRMT13 PE=1 SV=2" "0.000" "False" "17.393" "12" "5" "5" "5" "481" "54.2" "8.09" "16.66" "5" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf05206, Pf05253, Pf11722" "54482" "ENSG00000122435" "TRMT13" "hsa:54482; Q5VVL0; Q9NUP7; Q9NW65" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.051" "1.063" "0.948" "0.998" "1.093" "0.943" "1.024" "1.103" "1.023" "437.3" "459.7" "464.8" "414.5" "436.3" "477.7" "412.1" "447.7" "482.4" "447.5" "" "" "" "" "" "" "" "" "" "" "351.2" "331.7" "369.2" "277.7" "301.8" "358.4" "288.6" "326.9" "482.4" "363.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7841713393868884800" "False" "High" "IsMasterProtein" "Q9BSL1" "Ubiquitin-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBAC1 PE=1 SV=1" "0.000" "False" "17.390" "14" "6" "6" "6" "405" "45.3" "4.92" "12.65" "6" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00627" "10422" "ENSG00000130560" "UBAC1" "hsa:10422; O75500; Q9BSL1; Q9UMW7" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.110" "1.030" "1.061" "1.165" "1.098" "1.278" "1.213" "1.132" "1.082" "176.1" "195.4" "181.3" "186.9" "205.1" "193.4" "224.9" "213.5" "199.3" "190.4" "" "" "" "" "" "" "" "" "" "" "141.4" "141.0" "144.0" "125.2" "141.9" "145.1" "157.5" "155.9" "199.3" "154.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3330412660782960382" "False" "High" "IsMasterProtein" "Q16594" "Transcription initiation factor TFIID subunit 9 OS=Homo sapiens OX=9606 GN=TAF9 PE=1 SV=1" "0.000" "False" "17.358" "10" "3" "5" "3" "264" "29.0" "8.66" "16.42" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02291" "6880" "ENSG00000273841; ENSG00000276463" "TAF9" "D3DWA3; hsa:6880; Q16594; Q5U0D1; Q9BTS1" "HATs acetylate histones; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "12" "0" "1.031" "0.956" "1.106" "1.067" "0.949" "1.110" "0.959" "0.955" "1.129" "498.4" "514.0" "476.7" "551.2" "531.9" "472.9" "553.4" "478.0" "475.8" "562.9" "" "" "" "" "" "" "" "" "" "" "400.3" "370.9" "378.6" "369.3" "367.9" "354.8" "387.4" "349.1" "475.8" "457.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7404612744659791932" "False" "High" "IsMasterProtein" "Q01658" "Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1" "0.000" "False" "17.354" "20" "4" "7" "4" "176" "19.4" "4.75" "22.50" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "1810" "ENSG00000117505" "DR1" "hsa:1810; Q01658" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "1.108" "1.033" "1.096" "1.067" "0.985" "1.129" "1.040" "1.061" "1.039" "694.3" "769.1" "717.4" "761.0" "741.1" "683.6" "784.1" "722.0" "736.4" "721.3" "" "" "" "" "" "" "" "" "" "" "557.7" "555.0" "569.8" "509.9" "512.6" "512.9" "549.0" "527.3" "736.4" "586.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5476878865190536687" "False" "High" "IsMasterProtein" "Q14693" "Phosphatidate phosphatase LPIN1 OS=Homo sapiens OX=9606 GN=LPIN1 PE=1 SV=2" "0.000" "False" "17.335" "6" "4" "4" "4" "890" "98.6" "6.58" "14.21" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf04571, Pf08235, Pf16876" "23175" "ENSG00000134324" "LPIN1" "A8MU38; B4DET9; B4DGS4; B4DGZ6; B5MC18; B7Z858; D6W506; E7ESE7; F5GY24; hsa:23175; Q14693; Q53T25" "Triglyceride biosynthesis; Depolymerization of the Nuclear Lamina; Synthesis of PC; Synthesis of PE" "Sterol regulatory element-binding proteins (SREBP) signaling; Adipogenesis; Transcription factor regulation in adipogenesis; Congenital generalized lipodystrophy" "8" "0" "0.742" "0.480" "0.550" "0.842" "1.067" "0.594" "0.851" "0.636" "0.859" "136.6" "101.4" "65.5" "75.1" "115.0" "145.7" "81.1" "116.3" "86.8" "117.2" "" "" "" "" "" "" "" "" "" "" "109.7" "73.1" "52.0" "50.3" "79.6" "109.3" "56.8" "84.9" "86.8" "95.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8813199514956100081" "False" "High" "IsMasterProtein" "O94822" "E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6" "0.000" "False" "17.327" "4" "6" "6" "6" "1766" "200.4" "6.25" "15.94" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "" "26046" "ENSG00000198862; ENSG00000291534" "LTN1" "A6NL41; A7E2D0; B2RTS0; C9J7U3; J3KPL4; O94822; Q05C47; Q9H8M4; Q9NUY5; Q9P0E9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.075" "1.020" "1.087" "1.046" "1.141" "1.104" "1.055" "1.084" "1.025" "663.4" "713.0" "676.7" "720.9" "694.1" "756.9" "732.1" "699.7" "718.9" "680.2" "" "" "" "" "" "" "" "" "" "" "532.8" "514.5" "537.5" "483.0" "480.1" "567.9" "512.6" "511.0" "718.9" "553.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492167490634941437" "False" "High" "IsMasterProtein" "P49914" "5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2" "0.000" "False" "17.325" "28" "5" "10" "5" "203" "23.2" "7.88" "20.32" "5" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01812" "10588" "ENSG00000136371" "MTHFS" "H3BQ75; hsa:10588; P49914" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Disorders of folate metabolism and transport" "4" "0" "0.987" "1.005" "0.909" "0.974" "0.960" "0.924" "0.964" "1.011" "0.995" "624.1" "615.7" "627.4" "567.4" "607.9" "599.3" "576.9" "601.7" "631.0" "621.2" "" "" "" "" "" "" "" "" "" "" "501.3" "444.3" "498.4" "380.1" "420.4" "449.6" "403.9" "439.4" "631.0" "505.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "208143562843118343" "False" "High" "IsMasterProtein" "Q8NFH5" "Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1" "0.000" "False" "17.306" "20" "5" "5" "5" "326" "34.8" "9.09" "14.29" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05172" "129401" "ENSG00000163002" "NUP35" "B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1" "HCMV Late Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "0.992" "0.976" "1.149" "1.084" "1.032" "0.987" "1.091" "1.070" "0.999" "245.5" "243.6" "239.6" "282.1" "266.1" "253.3" "242.3" "268.0" "262.6" "245.3" "" "" "" "" "" "" "" "" "" "" "197.2" "175.8" "190.3" "189.0" "184.0" "190.1" "169.6" "195.7" "262.6" "199.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8751597953454221886" "False" "High" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "0.000" "False" "17.296" "19" "6" "16" "6" "248" "27.1" "4.51" "46.95" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "MHC class II antigen presentation; Recycling pathway of L1; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "17" "0" "0.986" "1.019" "1.084" "1.050" "1.091" "1.162" "1.061" "1.032" "1.011" "1644.7" "1622.1" "1676.1" "1782.1" "1727.4" "1795.1" "1910.4" "1745.2" "1696.7" "1662.5" "" "" "" "" "" "" "" "" "" "" "1321.0" "1170.4" "1331.4" "1194.0" "1194.7" "1346.9" "1337.5" "1274.6" "1696.7" "1352.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917272071926626278" "False" "High" "IsMasterProtein" "Q99797" "Mitochondrial intermediate peptidase OS=Homo sapiens OX=9606 GN=MIPEP PE=1 SV=2" "0.000" "False" "17.287" "6" "5" "6" "5" "713" "80.6" "7.05" "18.65" "5" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01432" "4285" "ENSG00000027001" "MIPEP" "hsa:4285; Q5JV15; Q5T9Q9; Q96G65; Q99797" "" "13q12.12 copy number variation" "1" "0" "0.952" "0.874" "1.000" "0.933" "0.897" "0.891" "0.946" "0.966" "0.981" "107.6" "102.5" "94.1" "107.6" "100.4" "96.6" "95.9" "101.8" "104.0" "105.6" "" "" "" "" "" "" "" "" "" "" "86.5" "74.0" "74.7" "72.1" "69.5" "72.5" "67.2" "74.4" "104.0" "85.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2036393970743301611" "False" "High" "IsMasterProtein" "Q8N9M5" "Transmembrane protein 102 OS=Homo sapiens OX=9606 GN=TMEM102 PE=1 SV=1" "0.000" "False" "17.249" "8" "3" "3" "3" "508" "54.1" "5.91" "11.91" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "" "" "284114" "ENSG00000181284; ENSG00000284228" "TMEM102" "D3DTP8; hsa:284114; Q8N9M5" "" "" "0" "0" "0.980" "1.045" "1.167" "1.197" "0.999" "1.234" "1.128" "1.194" "1.122" "255.5" "250.4" "267.1" "298.2" "305.9" "255.4" "315.2" "288.2" "305.1" "286.6" "" "" "" "" "" "" "" "" "" "" "205.2" "180.7" "212.2" "199.8" "211.6" "191.6" "220.7" "210.5" "305.1" "233.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-618905356124197811" "False" "High" "IsMasterProtein" "Q9NQZ5" "StAR-related lipid transfer protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=STARD7 PE=1 SV=2" "0.000" "False" "17.235" "12" "4" "4" "4" "370" "43.1" "8.95" "10.83" "4" "" "other membranes;mitochondrion" "other molecular function" "Pf01852" "56910" "ENSG00000084090" "STARD7" "D3DXG9; hsa:56910; Q53T44; Q6GU43; Q969M6; Q9NQZ5" "Mitochondrial protein degradation; Synthesis of PC" "2q11.2 copy number variation syndrome" "3" "0" "1.017" "0.969" "1.032" "0.946" "0.926" "1.039" "1.016" "0.999" "1.001" "509.8" "518.4" "493.9" "526.0" "482.2" "471.9" "529.6" "517.8" "509.4" "510.3" "" "" "" "" "" "" "" "" "" "" "409.5" "374.1" "392.3" "352.4" "333.5" "354.1" "370.8" "378.2" "509.4" "415.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400072782813286453" "False" "High" "IsMasterProtein" "P62424" "Large ribosomal subunit protein eL8 OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2" "0.000" "False" "17.228" "17" "4" "5" "4" "266" "30.0" "10.61" "17.86" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6130" "ENSG00000148303; ENSG00000280858" "RPL7A" "hsa:6130; P11518; P62424; Q5T8U4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.000" "1.050" "1.133" "1.053" "1.079" "1.134" "0.945" "1.151" "1.013" "417.8" "417.8" "438.8" "473.2" "439.9" "450.7" "473.7" "394.7" "480.7" "423.2" "" "" "" "" "" "" "" "" "" "" "335.6" "301.5" "348.5" "317.1" "304.3" "338.2" "331.6" "288.2" "480.7" "344.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6979715234218397145" "False" "High" "IsMasterProtein" "Q9BVC3" "Sister chromatid cohesion protein DCC1 OS=Homo sapiens OX=9606 GN=DSCC1 PE=1 SV=2" "0.000" "False" "17.221" "11" "4" "4" "4" "393" "44.8" "5.17" "12.77" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09724" "79075" "ENSG00000136982" "DSCC1" "hsa:79075; Q969N5; Q9BVC3" "Polymerase switching on the C-strand of the telomere" "Gastric cancer network 2" "2" "0" "1.160" "1.002" "1.085" "1.093" "1.018" "1.124" "1.146" "1.134" "1.051" "294.5" "341.6" "295.1" "319.5" "321.9" "299.7" "330.9" "337.5" "333.9" "309.5" "" "" "" "" "" "" "" "" "" "" "236.5" "246.5" "234.4" "214.0" "222.7" "224.9" "231.7" "246.5" "333.9" "251.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974291959383986730" "False" "High" "IsMasterProtein" "Q9UL33" "Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1" "0.000" "False" "17.207" "22" "3" "8" "3" "140" "16.1" "6.77" "27.02" "3" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04628" "51693" "ENSG00000167515" "TRAPPC2L" "B2R4M9; hsa:51693; Q6ZTA7; Q9NZZ4; Q9UL33" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.077" "1.055" "1.011" "1.040" "1.043" "0.955" "0.988" "1.068" "0.969" "486.6" "524.2" "513.6" "491.8" "506.2" "507.4" "464.8" "480.6" "519.6" "471.6" "" "" "" "" "" "" "" "" "" "" "390.8" "378.3" "407.9" "329.5" "350.1" "380.7" "325.5" "351.0" "519.6" "383.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711793945183504944" "False" "High" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "0.000" "False" "17.203" "17" "2" "4" "2" "173" "18.9" "4.88" "14.25" "2" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905; ENSG00000291958" "GCSH" "hsa:2653; P23434; Q9H1E9" "Glycine degradation" "" "2" "0" "1.096" "1.063" "0.947" "0.918" "1.134" "1.033" "0.997" "1.273" "1.183" "331.6" "363.3" "352.4" "313.9" "304.4" "376.1" "342.6" "330.8" "422.3" "392.2" "" "" "" "" "" "" "" "" "" "" "266.4" "262.2" "279.9" "210.3" "210.6" "282.2" "239.9" "241.6" "422.3" "319.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9128432651374987381" "False" "High" "IsMasterProtein" "Q9NNW5" "tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1" "0.000" "False" "17.195" "4" "4" "5" "4" "1121" "121.6" "6.87" "17.79" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00400" "11180" "ENSG00000178252" "WDR6" "B4DHK2; hsa:11180; Q3MIT1; Q9NNW5; Q9UF63" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3778187452605941811" "False" "High" "IsMasterProtein" "Q9NZ52" "ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1" "0.000" "False" "17.169" "6" "4" "6" "4" "723" "78.3" "5.58" "17.13" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23163" "ENSG00000125447" "GGA3" "B7Z7E2; B7Z7M9; hsa:23163; J3KRN0; Q15017; Q6IS16; Q9NZ52; Q9UJY3" "Amyloid fiber formation; TBC/RABGAPs; MET receptor recycling" "" "3" "0" "1.087" "0.990" "1.084" "0.972" "0.967" "1.070" "0.969" "0.993" "1.044" "411.9" "447.9" "407.7" "446.6" "400.3" "398.2" "440.9" "399.3" "409.2" "430.0" "" "" "" "" "" "" "" "" "" "" "330.8" "323.2" "323.9" "299.2" "276.8" "298.8" "308.7" "291.6" "409.2" "349.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-359770206824869393" "False" "High" "IsMasterProtein" "P50747" "Biotin--protein ligase OS=Homo sapiens OX=9606 GN=HLCS PE=1 SV=1" "0.000" "False" "17.164" "11" "6" "6" "6" "726" "80.7" "5.62" "17.06" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02237, Pf03099" "3141" "ENSG00000159267" "HLCS" "B2RAH1; D3DSG6; hsa:3141; P50747; Q99451" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "" "2" "0" "0.989" "1.022" "1.101" "1.077" "1.081" "1.036" "1.028" "0.984" "1.078" "179.4" "177.4" "183.4" "197.6" "193.2" "194.0" "186.0" "184.5" "176.6" "193.4" "" "" "" "" "" "" "" "" "" "" "144.1" "128.0" "145.7" "132.4" "133.6" "145.6" "130.2" "134.7" "176.6" "157.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7931435872977733703" "False" "High" "IsMasterProtein" "P05556" "Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1 PE=1 SV=2" "0.000" "False" "17.163" "5" "4" "4" "4" "798" "88.4" "5.39" "14.28" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00362, Pf07965, Pf07974, Pf08725, Pf17205, Pf18372" "3688" "ENSG00000150093" "ITGB1" "A8K6N2; D3DRX9; D3DRY3; D3DRY4; D3DRY5; hsa:3688; P05556; P78466; P78467; Q13089; Q13090; Q13091; Q13212; Q14622; Q14647; Q29RW2; Q7Z3V1; Q8WUM6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Potential therapeutics for SARS; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases Activate Formins; HCMV Early Events; RAC2 GTPase cycle; RAC3 GTPase cycle; Integrin cell surface interactions; ECM proteoglycans; GPER1 signaling; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; Signal transduction by L1; Syndecan interactions; Other semaphorin interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions; Formation of the ureteric bud; Platelet Adhesion to exposed collagen; Molecules associated with elastic fibres; TGF-beta receptor signaling activates SMADs; Fibronectin matrix formation; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; MET interacts with TNS proteins" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Cells and molecules involved in local acute inflammatory response ; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Small cell lung cancer; Gastrin signaling pathway; Genes controlling nephrogenesis; Development of ureteric collection system; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; 11p11.2 copy number variation syndrome ; Macrophage-stimulating protein (MSP) signaling network map; TAR syndrome; Cell lineage map for neuronal differentiation" "58" "0" "0.991" "0.956" "0.969" "1.029" "0.994" "0.996" "0.986" "1.137" "0.980" "146.3" "144.9" "139.8" "141.7" "150.6" "145.4" "145.7" "144.3" "166.3" "143.3" "" "" "" "" "" "" "" "" "" "" "117.5" "104.6" "111.1" "94.9" "104.1" "109.1" "102.0" "105.4" "166.3" "116.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1616595542625436951" "False" "High" "IsMasterProtein" "Q96LR5" "Ubiquitin-conjugating enzyme E2 E2 OS=Homo sapiens OX=9606 GN=UBE2E2 PE=1 SV=1" "0.000" "False" "17.158" "22" "4" "4" "2" "201" "22.2" "7.71" "13.51" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00179" "7325" "ENSG00000182247" "UBE2E2" "hsa:7325; Q96LR5" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "2" "0.975" "1.013" "1.044" "0.998" "0.972" "1.033" "0.941" "1.019" "1.031" "340.8" "332.3" "345.2" "355.8" "340.1" "331.1" "352.0" "320.6" "347.3" "351.5" "" "" "" "" "" "" "" "" "" "" "273.8" "239.8" "274.2" "238.4" "235.2" "248.4" "246.5" "234.1" "347.3" "285.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714801153834532541" "False" "High" "IsMasterProtein" "O14733" "Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2" "0.000" "False" "17.129" "13" "5" "6" "5" "419" "47.5" "9.16" "19.92" "5" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5609" "ENSG00000076984" "MAP2K7" "B2R9S5; D6W659; hsa:5609; O14648; O14733; O14816; O60452; O60453; Q1PG43; Q8IY10" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "28" "0" "1.087" "1.005" "1.106" "1.012" "0.942" "0.991" "0.965" "0.966" "1.023" "683.5" "743.0" "686.7" "756.0" "691.9" "644.1" "677.4" "659.2" "660.3" "699.1" "" "" "" "" "" "" "" "" "" "" "549.0" "536.1" "545.5" "506.5" "478.5" "483.2" "474.3" "481.4" "660.3" "568.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6043463436452304537" "False" "High" "IsMasterProtein" "Q5SSJ5" "Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1" "0.000" "False" "17.120" "8" "5" "6" "5" "553" "61.2" "9.67" "17.61" "5" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "50809" "ENSG00000127483" "HP1BP3" "A6NI71; A8K5D7; B3KMZ8; B4E210; hsa:50809; Q05BI0; Q5SSJ5; Q5SSJ6; Q5SWC6; Q6PIM9; Q8NDF0; Q9UHY0" "" "" "0" "0" "1.045" "1.037" "1.130" "1.018" "0.982" "0.975" "1.156" "1.080" "1.011" "568.1" "593.4" "588.9" "642.1" "578.5" "558.1" "553.7" "656.6" "613.6" "574.3" "" "" "" "" "" "" "" "" "" "" "456.3" "428.2" "467.8" "430.2" "400.1" "418.7" "387.7" "479.5" "613.6" "467.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6273876737902892662" "False" "High" "IsMasterProtein" "P83876" "Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1" "0.000" "False" "17.105" "13" "2" "5" "2" "142" "16.8" "5.85" "16.60" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf02966" "10907" "ENSG00000141759" "TXNL4A" "B2RC18; hsa:10907; O14834; P83876" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.049" "1.062" "1.075" "1.106" "1.048" "1.079" "1.060" "1.034" "1.044" "409.0" "429.2" "434.2" "439.5" "452.1" "428.7" "441.2" "433.7" "423.0" "427.0" "" "" "" "" "" "" "" "" "" "" "328.5" "309.7" "344.9" "294.4" "312.7" "321.6" "308.9" "316.7" "423.0" "347.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4536625609042411990" "False" "High" "IsMasterProtein" "Q16656" "Nuclear respiratory factor 1 OS=Homo sapiens OX=9606 GN=NRF1 PE=1 SV=1" "0.000" "False" "17.100" "8" "3" "4" "3" "503" "53.5" "5.05" "14.67" "3" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf10491" "4899" "ENSG00000106459" "NRF1" "A8K4C6; B4DDV6; hsa:4899; Q15305; Q16656; Q96AN2" "PPARA activates gene expression; Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; Interactions between LOXL4 and oxidative stress pathway; Mitochondrial gene expression; Sildenafil treatment" "6" "0" "1.027" "0.943" "0.923" "0.881" "0.976" "0.858" "0.800" "0.811" "0.928" "350.2" "359.8" "330.2" "323.4" "308.4" "341.9" "300.5" "280.4" "284.1" "324.9" "" "" "" "" "" "" "" "" "" "" "281.3" "259.6" "262.3" "216.7" "213.3" "256.5" "210.4" "204.8" "284.1" "264.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2811678325838740313" "False" "High" "IsMasterProtein" "Q9NXW9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1" "0.000" "False" "17.092" "12" "3" "5" "3" "302" "33.8" "6.67" "13.52" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "54784" "ENSG00000160993" "ALKBH4" "hsa:54784; Q53H92; Q9H6A4; Q9NXW9" "" "" "0" "0" "1.139" "1.051" "1.183" "0.877" "0.968" "0.805" "0.757" "0.916" "1.082" "138.4" "157.7" "145.5" "163.8" "121.4" "134.0" "111.4" "104.8" "126.9" "149.7" "" "" "" "" "" "" "" "" "" "" "111.2" "113.8" "115.6" "109.8" "83.9" "100.6" "78.0" "76.5" "126.9" "121.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1613875613327361847" "False" "High" "IsMasterProtein" "Q96G25" "Mediator of RNA polymerase II transcription subunit 8 OS=Homo sapiens OX=9606 GN=MED8 PE=1 SV=2" "0.000" "False" "17.091" "23" "5" "5" "5" "268" "29.1" "7.44" "14.06" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10232" "112950" "ENSG00000159479" "MED8" "A9IZ91; A9IZ92; hsa:112950; Q5JUY8; Q96FQ4; Q96G25" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.067" "1.022" "1.063" "0.967" "1.097" "1.011" "0.988" "1.037" "1.110" "366.5" "391.2" "374.7" "389.4" "354.5" "402.2" "370.6" "362.1" "379.9" "407.0" "" "" "" "" "" "" "" "" "" "" "294.4" "282.3" "297.6" "260.9" "245.2" "301.8" "259.5" "264.4" "379.9" "331.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3474294696230131597" "False" "High" "IsMasterProtein" "Q86WN1" "F-BAR and double SH3 domains protein 1 OS=Homo sapiens OX=9606 GN=FCHSD1 PE=1 SV=1" "0.000" "False" "17.075" "5" "3" "4" "3" "690" "76.9" "5.34" "11.35" "3" "cell-cell signaling;cell organization and biogenesis" "cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00611, Pf14604" "89848" "ENSG00000197948" "FCHSD1" "hsa:89848; Q6UX75; Q86WN1; Q86Y77; Q9NXX8" "" "" "0" "0" "0.941" "0.927" "1.023" "1.016" "0.970" "0.992" "1.042" "1.044" "0.937" "271.7" "255.7" "252.0" "277.9" "275.9" "263.6" "269.6" "283.2" "283.6" "254.7" "" "" "" "" "" "" "" "" "" "" "218.2" "184.5" "200.2" "186.2" "190.8" "197.8" "188.8" "206.8" "283.6" "207.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5416177737731563011" "False" "High" "IsMasterProtein" "Q14457" "Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2" "0.000" "False" "17.059" "10" "5" "5" "5" "450" "51.9" "4.89" "18.07" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04111, Pf15285, Pf17675" "8678" "ENSG00000126581" "BECN1" "B2R6N7; hsa:8678; O75595; Q14457; Q9UNA8" "Macroautophagy; RSV-host interactions; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Ub-specific processing proteases; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "18" "0" "1.136" "1.105" "1.117" "1.083" "1.057" "1.041" "1.040" "1.207" "1.052" "399.3" "453.6" "441.2" "446.1" "432.2" "422.0" "415.6" "415.3" "481.8" "420.1" "" "" "" "" "" "" "" "" "" "" "320.7" "327.3" "350.5" "298.9" "298.9" "316.6" "291.0" "303.3" "481.8" "341.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8670958433918101160" "False" "High" "IsMasterProtein" "P26373" "Large ribosomal subunit protein eL13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "0.000" "False" "17.049" "14" "3" "4" "3" "211" "24.2" "11.65" "14.45" "3" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.940" "1.110" "1.082" "0.981" "0.973" "1.153" "0.925" "1.027" "0.991" "474.4" "446.0" "526.7" "513.2" "465.3" "461.6" "547.0" "438.7" "487.4" "470.4" "" "" "" "" "" "" "" "" "" "" "381.1" "321.8" "418.4" "343.8" "321.8" "346.3" "383.0" "320.4" "487.4" "382.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2393292125676734128" "False" "High" "IsMasterProtein" "Q8IWY9" "Codanin-1 OS=Homo sapiens OX=9606 GN=CDAN1 PE=1 SV=4" "0.000" "False" "17.041" "4" "4" "4" "4" "1227" "134.0" "6.77" "12.68" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15296" "146059" "ENSG00000140326" "CDAN1" "hsa:146059; Q6NYD0; Q7Z7L5; Q8IWY9; Q969N3" "" "" "0" "0" "1.245" "1.016" "1.179" "1.069" "1.103" "1.005" "1.058" "1.222" "1.056" "175.0" "217.8" "177.8" "206.4" "187.1" "193.1" "175.9" "185.1" "213.9" "184.8" "" "" "" "" "" "" "" "" "" "" "140.6" "157.2" "141.3" "138.3" "129.4" "144.9" "123.1" "135.2" "213.9" "150.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1340431599886036183" "False" "High" "IsMasterProtein" "O60783" "Small ribosomal subunit protein uS14m OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1" "0.000" "False" "17.029" "19" "2" "4" "2" "128" "15.1" "11.41" "11.39" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00253" "63931" "ENSG00000120333" "MRPS14" "hsa:63931; O60783; Q5R358" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.051" "1.049" "1.211" "1.028" "0.840" "1.141" "1.221" "0.998" "1.040" "215.5" "226.6" "226.0" "261.0" "221.5" "181.1" "245.8" "263.0" "215.0" "224.1" "" "" "" "" "" "" "" "" "" "" "173.1" "163.5" "179.5" "174.9" "153.2" "135.8" "172.1" "192.1" "215.0" "182.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573185288358324905" "False" "High" "IsMasterProtein" "P21953" "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2" "0.000" "False" "17.008" "8" "3" "4" "3" "392" "43.1" "6.29" "15.21" "3" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02779, Pf02780" "594" "ENSG00000083123" "BCKDHB" "hsa:594; P21953; Q5T2J3; Q9BQL0" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "Primary ovarian insufficiency" "3" "0" "0.923" "0.935" "0.997" "0.982" "0.944" "0.924" "0.859" "0.833" "0.963" "582.6" "537.6" "544.7" "580.9" "571.9" "550.1" "538.3" "500.5" "485.3" "561.1" "" "" "" "" "" "" "" "" "" "" "468.0" "387.9" "432.7" "389.2" "395.5" "412.7" "376.9" "365.5" "485.3" "456.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7727085808198553563" "False" "High" "IsMasterProtein" "P30291" "Wee1-like protein kinase OS=Homo sapiens OX=9606 GN=WEE1 PE=1 SV=2" "0.000" "False" "17.003" "8" "4" "4" "4" "646" "71.6" "6.77" "12.62" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7465" "ENSG00000166483" "WEE1" "B3KVE1; D3DQV0; hsa:7465; P30291" "Factors involved in megakaryocyte development and platelet production; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control" "11" "0" "0.975" "1.051" "1.075" "1.095" "1.036" "1.168" "1.256" "1.181" "1.008" "177.4" "173.1" "186.5" "190.7" "194.3" "183.8" "207.3" "222.8" "209.5" "178.8" "" "" "" "" "" "" "" "" "" "" "142.5" "124.9" "148.1" "127.8" "134.4" "137.9" "145.1" "162.7" "209.5" "145.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279905099390366435" "False" "High" "IsMasterProtein" "Q6FIF0" "AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2" "0.000" "False" "17.002" "14" "3" "6" "3" "208" "22.5" "7.20" "17.22" "3" "cell organization and biogenesis;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "54469" "ENSG00000086666" "ZFAND6" "D3DW92; D3DW94; hsa:54469; O95792; Q6FIF0; Q9BQF7; Q9GZY3" "Peroxisomal protein import" "" "1" "0" "0.986" "1.026" "1.000" "1.046" "1.134" "1.107" "1.112" "1.021" "1.060" "607.0" "598.4" "622.7" "607.3" "635.2" "688.1" "671.9" "674.9" "619.9" "643.7" "" "" "" "" "" "" "" "" "" "" "487.5" "431.8" "494.6" "406.9" "439.3" "516.3" "470.5" "492.8" "619.9" "523.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2492705213444431370" "False" "High" "IsMasterProtein" "Q8TE04" "Pantothenate kinase 1 OS=Homo sapiens OX=9606 GN=PANK1 PE=1 SV=2" "0.000" "False" "16.994" "8" "5" "5" "2" "598" "64.3" "7.56" "13.82" "5" "other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf03630" "53354" "ENSG00000152782" "PANK1" "A6NIP0; hsa:53354; Q7RTX6; Q7Z495; Q8TBQ8; Q8TE04" "Coenzyme A biosynthesis" "" "1" "0" "0.878" "0.988" "0.881" "0.970" "1.021" "0.950" "1.062" "0.985" "1.027" "362.9" "318.7" "358.4" "319.8" "351.9" "370.4" "344.8" "385.3" "357.6" "372.7" "" "" "" "" "" "" "" "" "" "" "291.5" "229.9" "284.7" "214.3" "243.4" "277.9" "241.4" "281.4" "357.6" "303.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4865445723935678396" "False" "High" "IsMasterProtein" "Q13309" "S-phase kinase-associated protein 2 OS=Homo sapiens OX=9606 GN=SKP2 PE=1 SV=2" "0.000" "False" "16.987" "8" "3" "3" "3" "424" "47.7" "7.11" "11.88" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12937" "6502" "ENSG00000145604" "SKP2" "A8K5E0; B4DJT4; hsa:6502; Q13309; Q8TDZ0; Q8TDZ1; Q9BV69" "Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Regulation of BACH1 activity" "Cell cycle; Retinoblastoma gene in cancer; Imatinib and chronic myeloid leukemia" "13" "0" "0.975" "0.944" "0.837" "0.978" "0.918" "1.249" "1.202" "1.141" "1.077" "148.6" "144.9" "140.3" "124.4" "145.3" "136.3" "185.6" "178.6" "169.5" "160.1" "" "" "" "" "" "" "" "" "" "" "119.3" "104.6" "111.5" "83.3" "100.5" "102.3" "129.9" "130.4" "169.5" "130.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5356528915824417311" "False" "High" "IsMasterProtein" "Q7RTS9" "Dymeclin OS=Homo sapiens OX=9606 GN=DYM PE=1 SV=1" "0.000" "False" "16.975" "7" "5" "5" "5" "669" "75.9" "5.86" "16.26" "5" "cell organization and biogenesis;developmental processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf09742" "54808" "ENSG00000141627" "DYM" "A8K5I8; B2RCF9; B4DKI7; hsa:54808; Q3ZTS8; Q6P2P5; Q7RTS9; Q8N2M0; Q9BVE9; Q9NPU7" "" "" "0" "0" "1.180" "1.028" "1.134" "1.146" "1.090" "0.860" "1.148" "1.019" "1.189" "212.9" "251.3" "218.8" "241.5" "244.0" "232.2" "183.1" "244.5" "217.1" "253.1" "" "" "" "" "" "" "" "" "" "" "171.0" "181.3" "173.8" "161.8" "168.8" "174.2" "128.2" "178.5" "217.1" "205.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8922027540744871533" "False" "High" "IsMasterProtein" "Q9UHQ1" "Nuclear prelamin A recognition factor OS=Homo sapiens OX=9606 GN=NARF PE=1 SV=1" "0.000" "False" "16.962" "9" "4" "4" "3" "456" "51.1" "7.08" "15.55" "4" "" "cytoskeleton;nucleus" "other molecular function" "Pf02256, Pf02906" "26502" "ENSG00000141562" "NARF" "A6NCJ3; B3KPX2; hsa:26502; K4DI98; Q96AY9; Q9BWC6; Q9UHQ1" "" "Iron-sulfur cluster biogenesis" "1" "0" "0.951" "1.160" "1.140" "0.959" "0.945" "0.940" "0.859" "1.040" "0.972" "58.6" "55.8" "68.0" "66.8" "56.2" "55.4" "55.1" "50.4" "60.9" "57.0" "" "" "" "" "" "" "" "" "" "" "47.1" "40.2" "54.0" "44.8" "38.9" "41.6" "38.6" "36.8" "60.9" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2898803308841595735" "False" "High" "IsMasterProtein" "O00182" "Galectin-9 OS=Homo sapiens OX=9606 GN=LGALS9 PE=1 SV=2" "0.000" "False" "16.953" "14" "4" "5" "4" "355" "39.5" "9.17" "16.23" "4" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00337" "3965" "ENSG00000168961" "LGALS9" "A7VJG6; F8W9W4; hsa:3965; O00182; O14532; O75028; Q3B8N1; Q53FQ0; Q8WYQ7; Q9NQ58" "Interleukin-2 family signaling" "Vitamin D receptor pathway; Pleural mesothelioma; Immune infiltration in pancreatic cancer" "4" "0" "0.993" "0.901" "1.108" "1.111" "0.995" "1.152" "1.140" "1.072" "0.992" "207.9" "206.4" "187.2" "230.3" "230.9" "206.9" "239.4" "237.1" "222.8" "206.2" "" "" "" "" "" "" "" "" "" "" "167.0" "148.9" "148.7" "154.3" "159.7" "155.3" "167.6" "173.1" "222.8" "167.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3487009987400899106" "False" "High" "IsMasterProtein" "P13051" "Uracil-DNA glycosylase OS=Homo sapiens OX=9606 GN=UNG PE=1 SV=2" "0.000" "False" "16.948" "16" "4" "4" "4" "313" "34.6" "9.32" "14.66" "4" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;nucleus" "translation activity;nucleic acid binding activity;other molecular function" "Pf03167" "7374" "ENSG00000076248" "UNG" "A8K5M6; B2R8Y1; hsa:7374; O00637; O00719; P13051; Q93028" "Chromatin modifications during the maternal to zygotic transition (MZT)" "Base excision repair; DNA repair pathways, full network" "3" "0" "0.962" "0.942" "1.095" "1.099" "0.869" "1.358" "1.268" "1.319" "1.234" "78.0" "75.0" "73.5" "85.4" "85.7" "67.7" "105.9" "98.9" "102.9" "96.2" "" "" "" "" "" "" "" "" "" "" "62.6" "54.1" "58.4" "57.2" "59.3" "50.8" "74.1" "72.2" "102.9" "78.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6810289511595074622" "False" "High" "IsMasterProtein" "Q15758" "Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2" "0.000" "False" "16.926" "6" "3" "4" "3" "541" "56.6" "5.48" "14.80" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00375" "6510" "ENSG00000105281" "SLC1A5" "A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01; hsa:6510; O95720; Q15758; Q96RL9; Q9BWQ3; Q9UNP2" "RHOQ GTPase cycle; RHOH GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Amino acid transport across the plasma membrane" "TYROBP causal network in microglia; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Metabolic reprogramming in colon cancer; Ferroptosis; Amino acid metabolism in triple-negative breast cancer cells" "11" "0" "0.941" "0.791" "1.033" "1.140" "1.201" "1.591" "1.008" "1.239" "1.183" "129.4" "121.8" "102.4" "133.6" "147.5" "155.4" "205.8" "130.5" "160.2" "153.0" "" "" "" "" "" "" "" "" "" "" "103.9" "87.9" "81.3" "89.5" "102.0" "116.6" "144.1" "95.3" "160.2" "124.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3577939540596101206" "False" "High" "IsMasterProtein" "Q96HD9" "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) OS=Homo sapiens OX=9606 GN=ACY3 PE=1 SV=1" "0.000" "False" "16.924" "17" "4" "4" "4" "319" "35.2" "5.90" "12.83" "4" "" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf04952" "91703" "ENSG00000132744" "ACY3" "hsa:91703; Q96HD9" "Aflatoxin activation and detoxification" "" "1" "0" "0.869" "0.839" "0.948" "0.846" "1.030" "0.735" "1.030" "0.937" "0.975" "123.6" "107.5" "103.7" "117.2" "104.6" "127.4" "90.9" "127.3" "115.9" "120.5" "" "" "" "" "" "" "" "" "" "" "99.3" "77.5" "82.4" "78.5" "72.3" "95.6" "63.6" "93.0" "115.9" "98.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3764290193644051117" "False" "High" "IsMasterProtein" "Q8WU10" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYROXD1 PE=1 SV=1" "0.000" "False" "16.914" "10" "4" "5" "4" "500" "55.8" "5.85" "14.86" "4" "stress response" "cytoskeleton;nucleus" "other molecular function" "Pf07992, Pf18267" "79912" "ENSG00000121350" "PYROXD1" "A6NKI6; B3KWN8; hsa:79912; Q8WU10; Q9H6P1" "" "" "0" "0" "1.179" "1.029" "1.307" "1.100" "1.110" "1.048" "1.086" "1.039" "1.205" "202.3" "238.6" "208.2" "264.5" "222.6" "224.5" "212.1" "219.8" "210.2" "243.7" "" "" "" "" "" "" "" "" "" "" "162.5" "172.1" "165.4" "177.2" "153.9" "168.5" "148.5" "160.5" "210.2" "198.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480523710602738279" "False" "High" "IsMasterProtein" "Q9BPZ3" "Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1" "0.000" "False" "16.910" "27" "3" "5" "3" "127" "15.0" "4.12" "17.46" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "51247" "ENSG00000120727" "PAIP2" "B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8" "" "" "0" "0" "0.938" "0.955" "1.084" "0.980" "1.116" "1.096" "1.020" "1.090" "1.045" "516.1" "484.2" "492.9" "559.2" "505.9" "576.1" "565.4" "526.2" "562.4" "539.2" "" "" "" "" "" "" "" "" "" "" "414.5" "349.4" "391.5" "374.7" "349.9" "432.2" "395.9" "384.3" "562.4" "438.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "784332711560809760" "False" "High" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "0.000" "False" "16.853" "52" "4" "10" "4" "90" "10.3" "6.29" "26.90" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "Mitochondrial protein degradation; Mitochondrial protein import" "" "2" "0" "1.087" "1.084" "1.196" "1.098" "1.145" "1.142" "1.004" "0.973" "1.132" "372.2" "404.5" "403.5" "445.1" "408.5" "426.4" "425.0" "373.7" "362.3" "421.3" "" "" "" "" "" "" "" "" "" "" "299.0" "291.9" "320.5" "298.2" "282.5" "319.9" "297.6" "272.9" "362.3" "342.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1176830711489117496" "False" "High" "IsMasterProtein" "Q7L1V2" "Vacuolar fusion protein MON1 homolog B OS=Homo sapiens OX=9606 GN=MON1B PE=1 SV=1" "0.000" "False" "16.829" "7" "3" "4" "3" "547" "59.2" "6.29" "12.16" "3" "transport;other biological processes" "other cytoplasmic organelle;other cell component" "" "Pf19036, Pf19037, Pf19038" "22879" "ENSG00000103111" "MON1B" "B4DDZ0; hsa:22879; O94949; Q7L1V2" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.059" "1.017" "1.215" "1.092" "0.903" "1.080" "1.105" "1.108" "1.133" "227.1" "240.4" "230.8" "275.9" "247.9" "205.0" "245.2" "250.8" "251.6" "257.2" "" "" "" "" "" "" "" "" "" "" "182.4" "173.5" "183.4" "184.8" "171.5" "153.8" "171.7" "183.2" "251.6" "209.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196363809325094679" "False" "High" "IsMasterProtein" "Q9HCU8" "DNA polymerase delta subunit 4 OS=Homo sapiens OX=9606 GN=POLD4 PE=1 SV=1" "0.000" "False" "16.819" "23" "2" "2" "2" "107" "12.4" "6.77" "9.20" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf04081" "57804" "ENSG00000175482" "POLD4" "F5H506; hsa:57804; Q9HCU8" "Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "25" "0" "1.123" "0.971" "1.143" "1.047" "1.144" "0.684" "0.622" "0.621" "0.990" "263.0" "295.3" "255.3" "300.5" "275.3" "300.8" "179.8" "163.6" "163.3" "260.3" "" "" "" "" "" "" "" "" "" "" "211.2" "213.1" "202.8" "201.3" "190.4" "225.7" "125.9" "119.5" "163.3" "211.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8714366505281620526" "False" "High" "IsMasterProtein" "Q7L5Y9" "E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1" "0.000" "False" "16.816" "12" "5" "6" "5" "396" "45.3" "8.69" "19.94" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10607" "10296" "ENSG00000090316" "MAEA" "hsa:10296; O95285; Q5JB54; Q6ZRD6; Q7L5Y9; Q9BQ11; Q9H9V6; Q9H9Z4; Q9NW84" "" "Ciliary landscape" "1" "0" "1.033" "0.976" "0.991" "1.035" "0.989" "0.923" "1.004" "1.023" "1.047" "491.8" "508.3" "480.3" "487.3" "509.1" "486.4" "453.9" "493.7" "503.3" "514.8" "" "" "" "" "" "" "" "" "" "" "395.0" "366.7" "381.5" "326.5" "352.1" "364.9" "317.8" "360.5" "503.3" "418.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1508959840554036408" "False" "High" "IsMasterProtein" "Q969V6" "Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1" "0.000" "False" "16.816" "5" "4" "5" "3" "931" "98.9" "5.86" "15.85" "4" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02037, Pf02755" "57591" "ENSG00000196588" "MRTFA" "hsa:57591; Q8TCL1; Q969V6; Q96SC5; Q96SC6; Q9P2B0" "RHO GTPases Activate Formins; SUMOylation of transcription cofactors" "" "2" "0" "1.154" "0.990" "1.079" "1.090" "1.094" "1.001" "1.025" "1.100" "1.022" "422.2" "487.3" "417.8" "455.6" "460.2" "461.8" "422.8" "432.7" "464.5" "431.7" "" "" "" "" "" "" "" "" "" "" "339.1" "351.6" "331.9" "305.2" "318.3" "346.5" "296.0" "316.0" "464.5" "351.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4026716302863274085" "False" "High" "IsMasterProtein" "Q5T5X7" "BEN domain-containing protein 3 OS=Homo sapiens OX=9606 GN=BEND3 PE=1 SV=1" "0.000" "False" "16.813" "5" "4" "4" "4" "828" "94.4" "5.43" "12.18" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10523" "57673" "ENSG00000178409" "BEND3" "A2RRH2; hsa:57673; Q5T5X7; Q9HCL9" "" "" "0" "0" "1.120" "1.142" "1.232" "1.207" "1.032" "0.879" "1.156" "0.977" "1.136" "46.1" "51.6" "52.6" "56.8" "55.7" "47.6" "40.5" "53.3" "45.0" "52.4" "" "" "" "" "" "" "" "" "" "" "37.0" "37.3" "41.8" "38.1" "38.5" "35.7" "28.4" "38.9" "45.0" "42.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4671672968224421805" "False" "High" "IsMasterProtein" "Q9NVK5" "FGFR1 oncogene partner 2 OS=Homo sapiens OX=9606 GN=FGFR1OP2 PE=1 SV=1" "0.000" "False" "16.812" "13" "3" "4" "3" "253" "29.4" "6.00" "14.10" "3" "stress response" "cytosol" "other molecular function" "Pf05769" "26127" "ENSG00000111790" "FGFR1OP2" "hsa:26127; Q6R955; Q8N5L7; Q9NVK5; Q9P034; Q9UFK8" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "2" "0" "1.115" "1.192" "1.118" "1.139" "1.306" "1.188" "1.174" "1.230" "1.283" "154.8" "172.6" "184.5" "173.0" "176.4" "202.2" "183.9" "181.7" "190.4" "198.6" "" "" "" "" "" "" "" "" "" "" "124.3" "124.5" "146.5" "115.9" "122.0" "151.7" "128.8" "132.7" "190.4" "161.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580559568770530829" "False" "High" "IsMasterProtein" "Q14135" "Transcription cofactor vestigial-like protein 4 OS=Homo sapiens OX=9606 GN=VGLL4 PE=1 SV=4" "0.000" "False" "16.799" "12" "3" "3" "3" "290" "30.9" "8.22" "9.91" "3" "other biological processes" "nucleus" "other molecular function" "Pf15245" "9686" "ENSG00000144560" "VGLL4" "B4DTS7; hsa:9686; J3KN68; Q14135; Q7L5V0; Q9BQ78" "" "Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "2" "0" "0.949" "0.916" "1.129" "1.163" "1.077" "1.112" "0.939" "0.954" "0.913" "116.1" "110.3" "106.4" "131.1" "135.1" "125.1" "129.2" "109.1" "110.8" "106.0" "" "" "" "" "" "" "" "" "" "" "93.3" "79.6" "84.5" "87.8" "93.4" "93.9" "90.5" "79.7" "110.8" "86.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8654405548002230634" "False" "High" "IsMasterProtein" "Q49B96" "Cytochrome c oxidase assembly protein COX19 OS=Homo sapiens OX=9606 GN=COX19 PE=1 SV=1" "0.000" "False" "16.798" "34" "3" "4" "3" "90" "10.4" "8.72" "14.11" "3" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf06747" "90639" "ENSG00000240230" "COX19" "A4FTX0; hsa:90639; Q49B96" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Mitochondrial protein import" "Mitochondrial complex IV assembly" "5" "0" "1.063" "1.069" "1.180" "1.231" "1.151" "1.181" "1.257" "1.138" "1.168" "420.7" "447.2" "449.6" "496.5" "517.9" "484.2" "496.7" "528.6" "478.5" "491.4" "" "" "" "" "" "" "" "" "" "" "337.9" "322.7" "357.1" "332.6" "358.2" "363.3" "347.8" "386.0" "478.5" "399.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "126204850056993689" "False" "High" "IsMasterProtein" "Q9NPB8" "Glycerophosphocholine phosphodiesterase GPCPD1 OS=Homo sapiens OX=9606 GN=GPCPD1 PE=1 SV=2" "0.000" "False" "16.797" "6" "4" "4" "4" "672" "76.0" "5.53" "13.39" "4" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00686, Pf03009" "56261" "ENSG00000125772" "GPCPD1" "D3DW06; hsa:56261; Q9BQL8; Q9NPB8; Q9NUX0" "Hydrolysis of LPC; Hydrolysis of LPE" "" "2" "0" "0.964" "0.979" "1.004" "0.889" "0.942" "0.843" "0.885" "0.937" "1.015" "541.3" "521.9" "529.7" "543.2" "481.5" "509.8" "456.5" "479.2" "507.1" "549.3" "" "" "" "" "" "" "" "" "" "" "434.8" "376.6" "420.8" "364.0" "333.0" "382.5" "319.6" "349.9" "507.1" "446.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6091940501454683011" "False" "High" "IsMasterProtein" "Q9UNX4" "WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=WDR3 PE=1 SV=1" "0.000" "False" "16.793" "4" "4" "5" "4" "943" "106.0" "6.64" "14.02" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf04003, Pf12894" "10885" "ENSG00000065183" "WDR3" "hsa:10885; Q9UNX4" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.978" "1.084" "1.034" "1.003" "1.054" "0.971" "0.906" "0.873" "0.965" "211.9" "207.3" "229.7" "219.1" "212.5" "223.4" "205.8" "191.9" "185.0" "204.6" "" "" "" "" "" "" "" "" "" "" "170.2" "149.6" "182.5" "146.8" "147.0" "167.6" "144.1" "140.2" "185.0" "166.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549685978582378632" "False" "High" "IsMasterProtein" "Q9Y399" "Small ribosomal subunit protein uS2m OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "0.000" "False" "16.788" "19" "6" "7" "6" "296" "33.2" "9.26" "18.83" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "4" "0" "1.072" "1.066" "1.047" "0.940" "0.949" "0.857" "0.939" "0.922" "0.955" "723.1" "775.4" "771.0" "757.0" "679.4" "686.5" "619.5" "679.1" "666.8" "690.3" "" "" "" "" "" "" "" "" "" "" "580.8" "559.5" "612.4" "507.2" "469.9" "515.1" "433.8" "495.9" "666.8" "561.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939925399894006679" "False" "High" "IsMasterProtein" "Q9NWU2" "Glucose-induced degradation protein 8 homolog OS=Homo sapiens OX=9606 GN=GID8 PE=1 SV=1" "0.000" "False" "16.786" "18" "4" "7" "4" "228" "26.7" "4.97" "24.37" "4" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08513, Pf10607" "54994" "ENSG00000101193" "GID8" "E1P5I3; hsa:54994; Q8N5M5; Q9NWU2" "" "Ciliary landscape" "1" "0" "1.010" "0.970" "1.098" "1.064" "1.063" "1.192" "1.090" "1.178" "1.103" "325.9" "329.3" "316.0" "357.8" "346.8" "346.5" "388.5" "355.2" "383.9" "359.6" "" "" "" "" "" "" "" "" "" "" "261.7" "237.6" "251.0" "239.7" "239.8" "260.0" "272.0" "259.4" "383.9" "292.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8583026759934693939" "False" "High" "IsMasterProtein" "Q9P1Z2" "Calcium-binding and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CALCOCO1 PE=1 SV=2" "0.000" "False" "16.770" "5" "3" "3" "3" "691" "77.3" "4.82" "10.86" "3" "cell-cell signaling;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07888, Pf17751, Pf18112" "57658" "ENSG00000012822" "CALCOCO1" "B3KVA8; hsa:57658; Q6FI59; Q71RC3; Q86WF8; Q96JU3; Q9H090; Q9P1Z2" "" "" "0" "0" "1.072" "0.944" "1.009" "0.910" "0.895" "0.938" "0.949" "0.955" "0.950" "204.7" "219.5" "193.2" "206.5" "186.2" "183.2" "192.1" "194.2" "195.6" "194.4" "" "" "" "" "" "" "" "" "" "" "164.4" "158.4" "153.5" "138.4" "128.8" "137.4" "134.5" "141.8" "195.6" "158.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-737330374784277396" "False" "High" "IsMasterProtein" "Q6ZV73" "FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens OX=9606 GN=FGD6 PE=1 SV=2" "0.000" "False" "16.742" "3" "5" "5" "5" "1430" "160.7" "7.03" "14.23" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "55785" "ENSG00000180263" "FGD6" "hsa:55785; Q6ZR53; Q6ZV73; Q7Z2Z7; Q96D44; Q9NUR8; Q9P2I5" "" "" "0" "0" "0.987" "1.053" "1.011" "1.000" "1.014" "0.970" "1.014" "1.048" "0.993" "312.1" "308.0" "328.7" "315.5" "312.0" "316.5" "302.8" "316.5" "327.0" "310.0" "" "" "" "" "" "" "" "" "" "" "250.6" "222.3" "261.1" "211.4" "215.7" "237.5" "212.0" "231.2" "327.0" "252.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3718082725162177882" "False" "High" "IsMasterProtein" "O95822" "Malonyl-CoA decarboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=MLYCD PE=1 SV=3" "0.000" "False" "16.737" "7" "3" "3" "3" "493" "55.0" "8.95" "11.58" "3" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05292, Pf17408" "23417" "ENSG00000103150" "MLYCD" "hsa:23417; O95822; Q9UNU5; Q9Y3F2" "" "" "0" "0" "1.006" "0.996" "1.087" "1.075" "1.030" "0.957" "0.977" "0.952" "0.977" "310.8" "312.6" "309.4" "337.8" "334.1" "320.0" "297.5" "303.7" "295.8" "303.5" "" "" "" "" "" "" "" "" "" "" "249.6" "225.6" "245.8" "226.3" "231.1" "240.1" "208.3" "221.8" "295.8" "246.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7929132600900675326" "False" "High" "IsMasterProtein" "Q53GL7" "Protein mono-ADP-ribosyltransferase PARP10 OS=Homo sapiens OX=9606 GN=PARP10 PE=1 SV=2" "0.000" "False" "16.709" "3" "2" "2" "2" "1025" "109.9" "4.97" "11.05" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00644" "84875" "ENSG00000178685" "PARP10" "hsa:84875; Q53GL7; Q8N2I0; Q8WV05; Q96CH7; Q96K72" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "" "3" "0" "1.115" "1.232" "1.264" "1.170" "1.035" "1.156" "1.074" "1.102" "1.160" "112.2" "125.1" "138.2" "141.8" "131.2" "116.1" "129.7" "120.5" "123.7" "130.2" "" "" "" "" "" "" "" "" "" "" "90.1" "90.3" "109.8" "95.0" "90.8" "87.1" "90.8" "88.0" "123.7" "105.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658757101665122516" "False" "High" "IsMasterProtein" "Q9ULP9" "TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2" "0.000" "False" "16.701" "12" "7" "8" "7" "559" "62.9" "7.36" "17.73" "7" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00566, Pf07534" "57465" "ENSG00000162065" "TBC1D24" "A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9" "TBC/RABGAPs" "" "1" "0" "1.169" "1.050" "1.126" "1.123" "1.081" "1.086" "1.084" "1.102" "1.226" "284.4" "332.4" "298.5" "320.3" "319.4" "307.3" "308.8" "308.3" "313.6" "348.8" "" "" "" "" "" "" "" "" "" "" "228.5" "239.8" "237.1" "214.6" "220.9" "230.6" "216.2" "225.1" "313.6" "283.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1054037842820128470" "False" "High" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "0.000" "False" "16.698" "15" "2" "2" "2" "252" "25.4" "9.88" "11.45" "2" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "0.921" "1.069" "1.053" "1.040" "0.915" "1.028" "1.123" "1.069" "1.156" "114.1" "105.1" "122.0" "120.1" "118.7" "104.4" "117.2" "128.1" "122.0" "131.9" "" "" "" "" "" "" "" "" "" "" "91.6" "75.8" "96.9" "80.5" "82.1" "78.3" "82.1" "93.5" "122.0" "107.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5150422290065042412" "False" "High" "IsMasterProtein" "Q9BXL5" "Hemogen OS=Homo sapiens OX=9606 GN=HEMGN PE=1 SV=1" "0.000" "False" "16.689" "10" "5" "5" "5" "484" "55.3" "4.87" "16.11" "5" "other biological processes" "nucleus" "" "" "55363" "ENSG00000136929" "HEMGN" "hsa:55363; Q6XAR3; Q86XY5; Q9BXL5; Q9NPC0" "" "" "0" "0" "1.085" "1.057" "1.152" "1.077" "1.109" "1.126" "1.042" "0.978" "1.000" "262.1" "284.4" "277.0" "302.0" "282.4" "290.5" "295.1" "273.0" "256.4" "262.1" "" "" "" "" "" "" "" "" "" "" "210.5" "205.2" "220.1" "202.3" "195.3" "218.0" "206.6" "199.4" "256.4" "213.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2383613337026514959" "False" "High" "IsMasterProtein" "Q93052" "Lipoma-preferred partner OS=Homo sapiens OX=9606 GN=LPP PE=1 SV=1" "0.000" "False" "16.687" "6" "3" "10" "3" "612" "65.7" "7.37" "28.83" "3" "cell adhesion" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "4026" "ENSG00000145012" "LPP" "A1L4L6; D3DNV6; hsa:4026; Q8NFX5; Q93052" "" "MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement" "1" "0" "1.003" "0.944" "1.127" "1.231" "0.940" "1.179" "1.301" "1.047" "1.126" "298.1" "298.9" "281.3" "336.0" "367.1" "280.2" "351.4" "387.7" "312.2" "335.8" "" "" "" "" "" "" "" "" "" "" "239.4" "215.7" "223.4" "225.1" "253.9" "210.2" "246.0" "283.1" "312.2" "273.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6209481463683659801" "False" "High" "IsMasterProtein" "Q71F23" "Centromere protein U OS=Homo sapiens OX=9606 GN=CENPU PE=1 SV=1" "0.000" "False" "16.660" "6" "2" "2" "2" "418" "47.5" "9.13" "12.50" "2" "cell cycle OR cell proliferation;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf13097" "79682" "ENSG00000151725" "CENPU" "A2RRD9; hsa:79682; Q09GN2; Q32Q71; Q71F23; Q9H5G1" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "1.042" "0.999" "1.227" "1.321" "1.101" "1.334" "1.507" "1.333" "1.301" "86.3" "89.9" "86.1" "105.8" "113.9" "95.0" "115.1" "130.0" "115.0" "112.2" "" "" "" "" "" "" "" "" "" "" "69.3" "64.8" "68.4" "70.9" "78.8" "71.3" "80.6" "94.9" "115.0" "91.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5151232376153751801" "False" "High" "IsMasterProtein" "Q9UIM3" "FK506-binding protein-like OS=Homo sapiens OX=9606 GN=FKBPL PE=1 SV=1" "0.000" "False" "16.660" "12" "4" "5" "4" "349" "38.2" "5.50" "13.63" "4" "other biological processes" "non-structural extracellular;cytosol" "" "Pf00515" "63943" "ENSG00000204315; ENSG00000223666; ENSG00000224200; ENSG00000230907" "FKBPL" "A8K5V3; B0UYX8; hsa:63943; Q9H5G3; Q9UIM3" "The role of GTSE1 in G2/M progression after G2 checkpoint" "" "1" "0" "1.067" "1.025" "1.148" "1.073" "0.962" "1.090" "1.098" "1.000" "1.054" "361.8" "385.9" "371.0" "415.3" "388.1" "348.2" "394.5" "397.2" "361.9" "381.1" "" "" "" "" "" "" "" "" "" "" "290.6" "278.5" "294.7" "278.2" "268.4" "261.2" "276.2" "290.1" "361.9" "310.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740912979344048922" "False" "High" "IsMasterProtein" "Q99871" "HAUS augmin-like complex subunit 7 OS=Homo sapiens OX=9606 GN=HAUS7 PE=1 SV=4" "0.000" "False" "16.659" "12" "3" "3" "3" "358" "39.8" "4.75" "12.33" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "" "55559" "ENSG00000213397" "HAUS7" "B4DUH6; D3DWT9; Q96HS8; Q99871; Q9NP54; Q9UFH9" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "0.971" "1.005" "1.007" "1.083" "0.964" "0.977" "1.013" "1.116" "1.078" "166.3" "161.4" "167.2" "167.5" "180.2" "160.3" "162.5" "168.4" "185.5" "179.3" "" "" "" "" "" "" "" "" "" "" "133.6" "116.5" "132.8" "112.2" "124.6" "120.3" "113.8" "123.0" "185.5" "145.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967906594537230573" "False" "High" "IsMasterProtein" "Q9NUG6" "p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2" "0.000" "False" "16.643" "16" "2" "4" "2" "133" "15.5" "6.06" "14.73" "2" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "81572" "ENSG00000088356" "PDRG1" "B2R511; hsa:81572; Q96GP3; Q9BUW8; Q9NUG6" "" "" "0" "0" "1.062" "1.213" "1.094" "0.920" "1.048" "0.997" "0.997" "1.052" "1.013" "211.7" "224.9" "256.7" "231.6" "194.7" "221.8" "211.0" "211.1" "222.7" "214.4" "" "" "" "" "" "" "" "" "" "" "170.0" "162.3" "203.9" "155.2" "134.7" "166.4" "147.8" "154.2" "222.7" "174.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7553626301853439744" "False" "High" "IsMasterProtein" "P63146" "Ubiquitin-conjugating enzyme E2 B OS=Homo sapiens OX=9606 GN=UBE2B PE=1 SV=1" "0.000" "False" "16.639" "24" "2" "2" "1" "152" "17.3" "5.01" "11.29" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00179" "7320" "ENSG00000119048" "UBE2B" "B2R503; D3DQA2; hsa:7320; P23567; P63146; Q4PJ15; Q9D0J6" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Recognition of DNA damage by PCNA-containing replication complex" "Proteasome degradation; Male infertility" "6" "0" "0.923" "0.871" "0.934" "0.937" "1.055" "0.969" "0.931" "1.063" "0.998" "211.9" "195.6" "184.4" "197.8" "198.4" "223.6" "205.3" "197.2" "225.1" "211.5" "" "" "" "" "" "" "" "" "" "" "170.2" "141.2" "146.5" "132.5" "137.2" "167.8" "143.7" "144.0" "225.1" "172.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2714329419910624829" "False" "High" "IsMasterProtein" "P47985" "Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2" "0.000" "False" "16.619" "19" "5" "5" "5" "274" "29.6" "8.32" "15.73" "5" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "7386" "ENSG00000169021" "UQCRFS1" "A8K519; hsa:7386; P47985; Q6NVX5; Q9UPH2" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; Iron metabolism disorders; Arsenic metabolism and reactive oxygen species generation" "6" "0" "1.034" "0.919" "0.988" "0.962" "1.018" "0.820" "0.862" "0.913" "0.941" "508.5" "525.5" "467.1" "502.5" "489.2" "517.8" "417.1" "438.1" "464.4" "478.4" "" "" "" "" "" "" "" "" "" "" "408.4" "379.2" "371.0" "336.7" "338.3" "388.5" "292.0" "319.9" "464.4" "389.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198167910452048535" "False" "High" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=3" "0.000" "False" "16.613" "7" "5" "5" "5" "633" "69.5" "6.28" "13.99" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01834" "7515" "ENSG00000073050" "XRCC1" "hsa:7515; P18887; Q6IBS4; Q9HCB1" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "0.971" "1.007" "0.958" "0.945" "0.983" "0.944" "0.969" "0.978" "0.972" "791.3" "768.1" "796.5" "758.4" "747.5" "777.8" "746.6" "766.7" "773.7" "769.2" "" "" "" "" "" "" "" "" "" "" "635.6" "554.2" "632.7" "508.1" "517.0" "583.6" "522.7" "559.9" "773.7" "625.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846678346596657924" "False" "High" "IsMasterProtein" "Q7L775" "EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1" "0.000" "False" "16.610" "9" "5" "6" "5" "607" "70.3" "6.11" "20.41" "5" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf18658" "9852" "ENSG00000178567" "EPM2AIP1" "hsa:9852; O94866; Q7L775; Q9H3L3" "" "" "0" "0" "0.939" "0.968" "0.946" "0.927" "0.917" "0.921" "0.926" "0.969" "0.937" "1190.7" "1118.5" "1152.2" "1126.1" "1103.4" "1092.0" "1096.3" "1102.9" "1154.4" "1116.2" "" "" "" "" "" "" "" "" "" "" "956.4" "807.1" "915.2" "754.5" "763.1" "819.3" "767.6" "805.5" "1154.4" "907.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4487628495145980375" "False" "High" "IsMasterProtein" "Q13425" "Beta-2-syntrophin OS=Homo sapiens OX=9606 GN=SNTB2 PE=1 SV=1" "0.000" "False" "16.608" "11" "5" "6" "5" "540" "57.9" "8.82" "14.40" "5" "" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00595, Pf18012" "6645" "ENSG00000168807" "SNTB2" "hsa:6645; Q13425; Q9BY09" "" "" "0" "0" "0.925" "1.082" "0.954" "0.856" "0.905" "0.923" "0.961" "0.959" "0.937" "150.7" "139.3" "163.1" "143.8" "129.0" "136.3" "139.1" "144.9" "144.6" "141.2" "" "" "" "" "" "" "" "" "" "" "121.0" "100.5" "129.5" "96.4" "89.2" "102.3" "97.4" "105.8" "144.6" "114.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8194850060938304098" "False" "High" "IsMasterProtein" "Q8N5I9" "NOP protein chaperone 1 OS=Homo sapiens OX=9606 GN=NOPCHAP1 PE=1 SV=2" "0.000" "False" "16.608" "24" "4" "6" "4" "185" "20.1" "5.22" "16.30" "4" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf15370" "121053" "ENSG00000151131" "NOPCHAP1" "Q8N5I9" "" "" "0" "0" "1.015" "0.978" "1.095" "0.897" "0.933" "0.958" "0.994" "0.943" "0.933" "334.3" "339.3" "327.0" "366.2" "300.1" "311.8" "320.3" "332.2" "315.3" "312.0" "" "" "" "" "" "" "" "" "" "" "268.5" "244.8" "259.8" "245.4" "207.5" "234.0" "224.3" "242.6" "315.3" "253.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7515824926889841061" "False" "High" "IsMasterProtein" "Q8TDM0" "Breast carcinoma-amplified sequence 4 OS=Homo sapiens OX=9606 GN=BCAS4 PE=1 SV=1" "0.000" "False" "16.607" "11" "2" "4" "2" "211" "22.7" "5.86" "13.54" "2" "" "other cell component" "" "" "55653" "ENSG00000124243" "BCAS4" "hsa:55653; Q5TD52; Q5TD53; Q5TD54; Q5U5K7; Q5XKE8; Q8IXI7; Q8NEZ6; Q8TDL9; Q8TDM0; Q9NX13; Q9Y511" "" "" "0" "0" "0.923" "0.819" "0.951" "0.861" "0.877" "0.908" "0.839" "0.793" "0.943" "171.3" "158.2" "140.3" "162.8" "147.6" "150.2" "155.6" "143.8" "135.9" "161.5" "" "" "" "" "" "" "" "" "" "" "137.6" "114.1" "111.5" "109.1" "102.1" "112.7" "108.9" "105.0" "135.9" "131.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6853827814974880096" "False" "High" "IsMasterProtein" "P52747" "Zinc finger protein 143 OS=Homo sapiens OX=9606 GN=ZNF143 PE=1 SV=2" "0.000" "False" "16.603" "10" "6" "6" "6" "638" "68.9" "6.05" "19.64" "6" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7702" "ENSG00000166478" "ZNF143" "A8K518; B4DLY5; E7ER34; hsa:7702; O75559; P52747; Q8WUK9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "IL-18 signaling pathway" "4" "0" "1.012" "1.074" "1.012" "1.024" "1.092" "0.914" "1.007" "1.041" "1.059" "459.8" "465.2" "493.6" "465.3" "470.6" "502.2" "420.4" "463.1" "478.6" "486.8" "" "" "" "" "" "" "" "" "" "" "369.3" "335.7" "392.1" "311.7" "325.5" "376.8" "294.3" "338.2" "478.6" "395.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5652063056633213151" "False" "High" "IsMasterProtein" "Q9Y4C4" "Malignant fibrous histiocytoma-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MFHAS1 PE=1 SV=2" "0.000" "False" "16.597" "5" "5" "6" "5" "1052" "116.9" "7.88" "15.42" "5" "stress response;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13855" "9258" "ENSG00000147324" "MFHAS1" "hsa:9258; Q96CI0; Q9Y4C4" "" "8p23.1 copy number variation syndrome" "1" "0" "0.748" "0.600" "0.708" "0.643" "0.724" "0.718" "0.621" "0.640" "0.755" "239.7" "179.3" "143.9" "169.6" "154.2" "173.6" "172.1" "148.9" "153.4" "181.0" "" "" "" "" "" "" "" "" "" "" "192.5" "129.4" "114.3" "113.7" "106.6" "130.2" "120.5" "108.7" "153.4" "147.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1759740052719989179" "False" "High" "IsMasterProtein" "O14561" "Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3" "0.000" "False" "16.583" "19" "3" "13" "3" "156" "17.4" "4.93" "40.21" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "translation activity;other molecular function" "Pf00550" "4706" "ENSG00000004779" "NDUFAB1" "B2R4M1; O14561; Q9UNV1" "Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "1.032" "0.996" "0.942" "0.959" "1.002" "0.973" "1.089" "1.056" "1.041" "614.3" "633.8" "611.9" "578.5" "589.3" "615.5" "597.9" "669.1" "648.6" "639.7" "" "" "" "" "" "" "" "" "" "" "493.4" "457.3" "486.1" "387.6" "407.6" "461.8" "418.7" "488.7" "648.6" "520.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9176436912319366181" "False" "High" "IsMasterProtein" "Q9Y5Q9" "General transcription factor 3C polypeptide 3 OS=Homo sapiens OX=9606 GN=GTF3C3 PE=1 SV=1" "0.000" "False" "16.561" "4" "3" "3" "3" "886" "101.2" "5.07" "12.30" "3" "RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13181" "9330" "ENSG00000119041" "GTF3C3" "hsa:9330; Q4ZG48; Q86XJ8; Q8WX84; Q96B44; Q9H5I8; Q9NT97; Q9Y5Q9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "0.963" "1.034" "0.992" "0.937" "1.000" "0.924" "1.011" "0.990" "1.047" "230.3" "221.8" "238.2" "228.4" "215.8" "230.2" "212.7" "232.9" "228.0" "241.1" "" "" "" "" "" "" "" "" "" "" "185.0" "160.1" "189.2" "153.0" "149.2" "172.7" "148.9" "170.1" "228.0" "196.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8443546389451323737" "False" "High" "IsMasterProtein" "Q96HJ9" "Protein FMC1 homolog OS=Homo sapiens OX=9606 GN=FMC1 PE=1 SV=2" "0.000" "False" "16.523" "11" "1" "2" "1" "113" "12.7" "10.07" "9.39" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "" "Pf13233" "100996928; 154791" "ENSG00000164898" "FMC1" "B7Z4Q3; hsa:100996928; hsa:154791; Q75M90; Q96HJ9; Q9P0B3" "" "" "0" "0" "1.051" "1.104" "0.956" "1.013" "1.057" "0.955" "1.015" "1.026" "0.968" "215.0" "226.0" "237.3" "205.6" "217.8" "227.3" "205.3" "218.3" "220.6" "208.1" "" "" "" "" "" "" "" "" "" "" "172.7" "163.1" "188.5" "137.8" "150.7" "170.6" "143.8" "159.4" "220.6" "169.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187719389386559931" "False" "High" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "0.000" "False" "16.510" "24" "3" "6" "3" "147" "15.9" "8.21" "24.51" "3" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "0.970" "1.034" "0.966" "0.867" "0.997" "0.893" "0.904" "0.974" "0.910" "703.4" "682.5" "727.0" "679.5" "610.0" "701.6" "628.1" "635.8" "684.9" "640.4" "" "" "" "" "" "" "" "" "" "" "564.9" "492.5" "577.5" "455.3" "421.9" "526.4" "439.8" "464.3" "684.9" "520.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4123477520333659496" "False" "High" "IsMasterProtein" "Q7Z4G4" "tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1" "0.000" "False" "16.483" "7" "3" "4" "3" "463" "53.4" "7.78" "13.04" "3" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01170" "60487" "ENSG00000066651" "TRMT11" "E1P570; hsa:60487; Q5JY11; Q6PGQ5; Q7Z4G4; Q9HC13" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.007" "0.983" "0.865" "0.932" "1.104" "0.940" "1.039" "1.026" "0.993" "370.6" "373.1" "364.4" "320.7" "345.2" "409.2" "348.3" "385.1" "380.2" "368.0" "" "" "" "" "" "" "" "" "" "" "297.6" "269.2" "289.5" "214.9" "238.8" "307.0" "243.9" "281.2" "380.2" "299.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337830748365545884" "False" "High" "IsMasterProtein" "Q53FT3" "Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2" "0.000" "False" "16.481" "18" "3" "4" "3" "197" "21.6" "5.45" "12.41" "3" "cell organization and biogenesis;stress response;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf05603, Pf21057" "51501" "ENSG00000149196" "HIKESHI" "hsa:51501; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.936" "0.993" "0.839" "0.998" "1.016" "1.012" "1.020" "0.989" "1.054" "356.5" "333.6" "354.1" "299.0" "355.6" "362.3" "360.7" "363.5" "352.4" "375.9" "" "" "" "" "" "" "" "" "" "" "286.3" "240.7" "281.3" "200.3" "245.9" "271.8" "252.5" "265.4" "352.4" "305.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2630059452900541435" "False" "High" "IsMasterProtein" "P21675" "Transcription initiation factor TFIID subunit 1 OS=Homo sapiens OX=9606 GN=TAF1 PE=1 SV=3" "0.000" "False" "16.475" "3" "6" "6" "6" "1893" "214.6" "5.06" "19.57" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf09247, Pf12157, Pf15288" "6872" "ENSG00000147133" "TAF1" "A5CVC8; A5CVC9; A5CVD0; A5CVD1; B1Q2X3; hsa:6872; P21675; Q59FZ3; Q6IUZ1; Q70Q86; Q70Q87; Q70T00; Q70T01; Q70T02; Q70T03" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "MECP2 and associated Rett syndrome" "10" "0" "1.035" "1.055" "1.021" "1.099" "1.005" "1.001" "1.119" "1.118" "1.103" "518.1" "536.1" "546.5" "528.8" "569.3" "520.5" "518.9" "579.8" "579.4" "571.3" "" "" "" "" "" "" "" "" "" "" "416.2" "386.8" "434.1" "354.3" "393.7" "390.5" "363.3" "423.5" "579.4" "464.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751278663907923034" "False" "High" "IsMasterProtein" "Q9UFG5" "UPF0449 protein C19orf25 OS=Homo sapiens OX=9606 GN=C19orf25 PE=1 SV=2" "0.000" "False" "16.470" "35" "4" "6" "4" "118" "12.9" "5.07" "19.20" "4" "" "" "" "Pf15136" "148223" "ENSG00000119559" "C19orf25" "B3KQN6; hsa:148223; Q8N9R7; Q8WV94; Q9UFG5" "" "" "0" "0" "1.018" "1.115" "1.124" "1.005" "1.057" "1.027" "0.923" "1.077" "1.065" "63.8" "64.9" "71.1" "71.7" "64.1" "67.4" "65.5" "58.9" "68.7" "67.9" "" "" "" "" "" "" "" "" "" "" "51.2" "46.9" "56.5" "48.0" "44.3" "50.6" "45.8" "43.0" "68.7" "55.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580197304848334652" "False" "High" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "0.000" "False" "16.466" "8" "5" "6" "5" "603" "69.9" "8.18" "19.26" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "0.963" "0.914" "1.105" "0.973" "0.965" "1.004" "0.981" "1.003" "0.963" "123.7" "119.1" "113.1" "136.7" "120.3" "119.4" "124.2" "121.4" "124.1" "119.2" "" "" "" "" "" "" "" "" "" "" "99.4" "86.0" "89.8" "91.6" "83.2" "89.6" "87.0" "88.6" "124.1" "96.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292844797767435028" "False" "High" "IsMasterProtein" "Q9H074" "Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1" "0.000" "False" "16.462" "6" "3" "5" "3" "479" "53.5" "4.81" "14.56" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854, Pf07145" "10605" "ENSG00000172239" "PAIP1" "A6NKV8; hsa:10605; O60455; Q96B61; Q9BS63; Q9H074" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors" "4" "0" "1.012" "1.066" "1.113" "1.030" "1.092" "1.020" "0.990" "1.029" "1.018" "497.3" "503.1" "530.0" "553.8" "512.4" "543.3" "507.0" "492.1" "512.0" "506.3" "" "" "" "" "" "" "" "" "" "" "399.4" "363.0" "421.0" "371.0" "354.3" "407.6" "355.0" "359.4" "512.0" "411.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3736107449275984803" "False" "High" "IsMasterProtein" "Q96M96" "FYVE, RhoGEF and PH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=FGD4 PE=1 SV=2" "0.000" "False" "16.457" "7" "5" "5" "5" "766" "86.6" "6.13" "17.53" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00621, Pf01363" "121512" "ENSG00000139132" "FGD4" "hsa:121512; Q6ULS2; Q8TCP6; Q96M96" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Intracellular trafficking proteins involved in CMT neuropathy" "6" "0" "0.894" "0.940" "0.972" "0.916" "0.921" "0.892" "0.968" "0.900" "0.946" "220.8" "197.3" "207.5" "214.6" "202.2" "203.4" "196.9" "213.8" "198.7" "208.9" "" "" "" "" "" "" "" "" "" "" "177.3" "142.4" "164.9" "143.8" "139.8" "152.6" "137.9" "156.1" "198.7" "169.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377279648093334159" "False" "High" "IsMasterProtein" "Q9UEE5" "Serine/threonine-protein kinase 17A OS=Homo sapiens OX=9606 GN=STK17A PE=1 SV=2" "0.000" "False" "16.451" "7" "3" "4" "3" "414" "46.5" "5.15" "14.50" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus" "kinase activity;other molecular function" "Pf00069" "9263" "ENSG00000164543" "STK17A" "A4D1V6; hsa:9263; Q8IVC8; Q9UEE5" "" "" "0" "0" "1.006" "0.993" "1.071" "0.971" "0.892" "0.929" "0.902" "0.919" "0.971" "440.1" "442.8" "437.1" "471.2" "427.6" "392.5" "408.9" "396.9" "404.7" "427.2" "" "" "" "" "" "" "" "" "" "" "353.5" "319.5" "347.2" "315.7" "295.7" "294.5" "286.3" "289.9" "404.7" "347.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076794450194740666" "False" "High" "IsMasterProtein" "Q5JWR5" "Protein dopey-1 OS=Homo sapiens OX=9606 GN=DOP1A PE=1 SV=1" "0.000" "False" "16.431" "2" "3" "3" "3" "2465" "277.2" "6.29" "12.20" "3" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "" "Pf04118" "23033" "ENSG00000083097" "DOP1A" "hsa:23033; Q5JWR5; Q86XV1; Q9H5J5; Q9NSL4; Q9UPN5; Q9Y414" "" "" "0" "0" "1.095" "0.992" "1.171" "1.019" "1.078" "1.095" "1.117" "1.014" "1.123" "117.3" "128.4" "116.4" "137.4" "119.5" "126.5" "128.5" "131.1" "118.9" "131.8" "" "" "" "" "" "" "" "" "" "" "94.2" "92.7" "92.4" "92.0" "82.7" "94.9" "90.0" "95.7" "118.9" "107.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1379432049065423837" "False" "High" "IsMasterProtein" "O75143" "Autophagy-related protein 13 OS=Homo sapiens OX=9606 GN=ATG13 PE=1 SV=1" "0.000" "False" "16.423" "13" "5" "5" "5" "517" "56.5" "5.12" "13.25" "5" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf10033" "9776" "ENSG00000175224" "ATG13" "B4DFI4; D3DQQ1; D3DQQ2; E9PQZ8; hsa:9776; O75143; Q53EN6; Q9BRL3; Q9H8B0" "Macroautophagy" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "12" "0" "1.026" "0.860" "1.127" "1.176" "1.049" "0.993" "1.194" "1.022" "1.075" "117.6" "120.7" "101.2" "132.6" "138.3" "123.3" "116.7" "140.3" "120.1" "126.4" "" "" "" "" "" "" "" "" "" "" "94.4" "87.1" "80.4" "88.8" "95.6" "92.5" "81.7" "102.5" "120.1" "102.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5788074156748143009" "False" "High" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "0.000" "False" "16.413" "12" "5" "6" "5" "420" "46.3" "7.21" "18.36" "5" "other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "Synthesis of GDP-mannose" "N-glycan biosynthesis" "2" "0" "1.013" "1.018" "1.018" "0.988" "0.985" "0.961" "1.008" "0.951" "0.992" "517.6" "524.2" "527.1" "527.1" "511.2" "509.6" "497.2" "521.9" "492.5" "513.3" "" "" "" "" "" "" "" "" "" "" "415.7" "378.3" "418.7" "353.1" "353.5" "382.4" "348.1" "381.1" "492.5" "417.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9211506236520866705" "False" "High" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "0.000" "False" "16.413" "14" "5" "8" "5" "339" "37.8" "4.97" "23.81" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "Cytosolic iron-sulfur cluster assembly" "2q11.2 copy number variation syndrome" "2" "0" "0.997" "0.990" "0.977" "1.056" "1.085" "1.019" "0.937" "1.010" "1.006" "425.8" "424.7" "421.5" "416.2" "449.9" "462.1" "433.7" "399.1" "430.3" "428.5" "" "" "" "" "" "" "" "" "" "" "342.0" "306.5" "334.8" "278.8" "311.1" "346.7" "303.7" "291.5" "430.3" "348.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1353658345851562217" "False" "High" "IsMasterProtein" "Q9BR76" "Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1" "0.000" "False" "16.396" "11" "6" "9" "6" "489" "54.2" "5.88" "24.40" "6" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "57175" "ENSG00000172725" "CORO1B" "B2RD45; hsa:57175; Q9BR76" "" "" "0" "0" "1.022" "0.983" "1.058" "1.078" "1.027" "1.075" "1.044" "1.042" "1.052" "946.6" "967.1" "930.6" "1001.5" "1020.0" "972.2" "1017.9" "987.9" "986.7" "996.3" "" "" "" "" "" "" "" "" "" "" "760.3" "697.8" "739.2" "671.0" "705.5" "729.4" "712.7" "721.5" "986.7" "810.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4878144000314540155" "False" "High" "IsMasterProtein" "Q9NWU5" "Large ribosomal subunit protein uL22m OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1" "0.000" "False" "16.360" "19" "4" "7" "4" "206" "23.6" "9.94" "19.53" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00237" "29093" "ENSG00000082515" "MRPL22" "A6NGJ8; hsa:29093; Q5H9Q1; Q96Q51; Q9NWU5; Q9P006" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.037" "0.997" "1.064" "0.985" "1.015" "1.024" "1.072" "1.051" "1.002" "706.8" "732.9" "704.5" "752.3" "696.3" "717.1" "723.9" "757.3" "742.8" "708.5" "" "" "" "" "" "" "" "" "" "" "567.7" "528.9" "559.6" "504.0" "481.6" "538.0" "506.8" "553.1" "742.8" "576.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9066609543119611752" "False" "High" "IsMasterProtein" "Q12851" "Mitogen-activated protein kinase kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP4K2 PE=1 SV=2" "0.000" "False" "16.358" "4" "3" "3" "3" "820" "91.5" "6.34" "11.96" "3" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "5871" "ENSG00000168067" "MAP4K2" "hsa:5871; Q12851; Q86VU3" "" "TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "7" "0" "1.275" "1.010" "1.458" "1.060" "1.175" "0.986" "1.106" "1.060" "1.126" "76.6" "97.7" "77.4" "111.7" "81.2" "90.0" "75.6" "84.7" "81.2" "86.2" "" "" "" "" "" "" "" "" "" "" "61.5" "70.5" "61.5" "74.8" "56.2" "67.5" "52.9" "61.9" "81.2" "70.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5837225809424381126" "False" "High" "IsMasterProtein" "P51826" "AF4/FMR2 family member 3 OS=Homo sapiens OX=9606 GN=AFF3 PE=1 SV=3" "0.000" "False" "16.345" "3" "4" "5" "3" "1226" "133.4" "8.10" "15.34" "4" "developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05110, Pf18875, Pf18876" "3899" "ENSG00000144218" "AFF3" "B7ZM46; B9EGL9; D3DVI6; P51826; Q53RD6; Q53S47; Q53SI6; Q53TB9; Q59F27; Q8IWJ5" "" "" "0" "0" "0.944" "0.948" "0.966" "1.115" "0.989" "1.012" "1.083" "0.838" "1.024" "63.4" "59.9" "60.1" "61.2" "70.7" "62.7" "64.2" "68.7" "53.1" "64.9" "" "" "" "" "" "" "" "" "" "" "50.9" "43.2" "47.7" "41.0" "48.9" "47.1" "44.9" "50.1" "53.1" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753103137801597372" "False" "High" "IsMasterProtein" "Q99618" "Cell division cycle-associated protein 3 OS=Homo sapiens OX=9606 GN=CDCA3 PE=1 SV=1" "0.000" "False" "16.344" "18" "4" "4" "4" "268" "29.0" "6.43" "12.92" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "" "83461" "ENSG00000111665" "CDCA3" "A8K5V6; D3DUS6; hsa:83461; Q99618" "" "" "0" "0" "1.021" "0.979" "1.103" "1.031" "0.977" "1.105" "1.029" "1.030" "1.060" "224.3" "229.1" "219.5" "247.5" "231.2" "219.1" "248.0" "230.9" "231.1" "237.7" "" "" "" "" "" "" "" "" "" "" "180.2" "165.3" "174.4" "165.8" "159.9" "164.4" "173.6" "168.6" "231.1" "193.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174147483962909046" "False" "High" "IsMasterProtein" "Q9NRX1" "RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1" "0.000" "False" "16.339" "25" "6" "6" "5" "252" "27.9" "9.73" "15.22" "6" "other biological processes" "cytosol;nucleus;other cell component" "" "" "56902" "ENSG00000115946" "PNO1" "A8K6Q0; hsa:56902; Q53G13; Q8WVB8; Q9NRX1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "1" "0.941" "1.046" "1.100" "1.146" "1.194" "1.171" "1.107" "1.095" "1.078" "322.7" "303.6" "337.5" "355.0" "369.7" "385.1" "377.9" "357.1" "353.4" "347.9" "" "" "" "" "" "" "" "" "" "" "259.2" "219.1" "268.1" "237.9" "255.7" "289.0" "264.6" "260.8" "353.4" "282.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558659697255910600" "False" "High" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=1 SV=2" "0.000" "False" "16.328" "11" "5" "6" "5" "370" "41.5" "8.18" "18.85" "5" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "0.931" "0.949" "0.925" "0.962" "0.948" "1.042" "0.931" "0.894" "0.908" "1007.1" "938.1" "955.6" "931.8" "969.0" "955.1" "1049.2" "937.5" "900.2" "914.0" "" "" "" "" "" "" "" "" "" "" "808.9" "676.9" "759.0" "624.3" "670.2" "716.6" "734.6" "684.6" "900.2" "743.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2572043715436263453" "False" "High" "IsMasterProtein" "Q9H3R5" "Centromere protein H OS=Homo sapiens OX=9606 GN=CENPH PE=1 SV=1" "0.000" "False" "16.305" "16" "4" "6" "4" "247" "28.5" "5.29" "20.83" "4" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "other molecular function" "Pf05837" "64946" "ENSG00000153044" "CENPH" "A8K3Y1; hsa:64946; Q9H3R5" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "0.992" "0.970" "1.037" "1.001" "1.017" "1.060" "1.026" "1.046" "1.077" "459.2" "455.4" "445.2" "476.0" "459.7" "466.9" "486.9" "471.1" "480.1" "494.5" "" "" "" "" "" "" "" "" "" "" "368.8" "328.6" "353.6" "318.9" "317.9" "350.3" "340.9" "344.0" "480.1" "402.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3242855938982215798" "False" "High" "IsMasterProtein" "Q9BQP7" "Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1" "0.000" "False" "16.302" "10" "3" "3" "3" "344" "39.4" "7.68" "11.61" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf12705" "92667" "ENSG00000125871" "MGME1" "B2RDG5; D3DW29; hsa:92667; Q96SW3; Q9BQP7" "" "Primary ovarian insufficiency" "1" "0" "1.058" "1.009" "0.984" "0.972" "1.041" "0.845" "0.954" "1.009" "1.051" "440.4" "465.9" "444.3" "433.4" "428.0" "458.6" "372.0" "419.9" "444.5" "462.7" "" "" "" "" "" "" "" "" "" "" "353.7" "336.2" "352.9" "290.4" "296.0" "344.0" "260.4" "306.7" "444.5" "376.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8504689738561094897" "False" "High" "IsMasterProtein" "O43303" "Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens OX=9606 GN=CCP110 PE=1 SV=3" "0.000" "False" "16.289" "5" "4" "5" "3" "1012" "113.4" "8.65" "17.84" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf16025" "9738" "ENSG00000103540" "CCP110" "B7WP23; hsa:9738; O43303; O43335; Q68DV9; Q8NE13" "Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle" "Joubert syndrome" "10" "0" "1.124" "1.130" "0.935" "1.126" "1.081" "1.286" "1.256" "1.156" "1.121" "115.2" "129.5" "130.3" "107.7" "129.8" "124.5" "148.2" "144.7" "133.2" "129.2" "" "" "" "" "" "" "" "" "" "" "92.6" "93.4" "103.5" "72.2" "89.7" "93.4" "103.8" "105.7" "133.2" "105.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6627286514823912553" "False" "High" "IsMasterProtein" "Q8TEA1" "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 OS=Homo sapiens OX=9606 GN=NSUN6 PE=1 SV=1" "0.000" "False" "16.288" "6" "2" "5" "2" "469" "51.7" "7.96" "18.70" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "221078" "ENSG00000241058" "NSUN6" "B0YJ54; hsa:221078; Q8TEA1" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.091" "1.068" "1.034" "1.046" "1.078" "1.042" "0.974" "0.987" "1.006" "311.6" "340.0" "332.7" "322.1" "326.0" "336.0" "324.7" "303.6" "307.7" "313.5" "" "" "" "" "" "" "" "" "" "" "250.3" "245.3" "264.3" "215.8" "225.5" "252.1" "227.3" "221.7" "307.7" "254.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1698124095596496194" "False" "High" "IsMasterProtein" "Q14147" "Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens OX=9606 GN=DHX34 PE=1 SV=2" "0.000" "False" "16.235" "4" "4" "5" "4" "1143" "128.0" "7.56" "11.67" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9704" "ENSG00000134815" "DHX34" "B4DMY8; hsa:9704; Q14147" "" "" "0" "0" "1.091" "1.102" "1.171" "1.171" "1.177" "1.190" "1.100" "1.134" "1.100" "304.3" "332.1" "335.2" "356.3" "356.2" "358.2" "362.1" "334.8" "344.9" "334.6" "" "" "" "" "" "" "" "" "" "" "244.4" "239.6" "266.3" "238.8" "246.4" "268.7" "253.5" "244.5" "344.9" "272.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731116703421718606" "False" "High" "IsMasterProtein" "Q53H80" "Akirin-2 OS=Homo sapiens OX=9606 GN=AKIRIN2 PE=1 SV=2" "0.000" "False" "16.228" "20" "4" "5" "4" "203" "22.5" "8.73" "13.75" "4" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "" "55122" "ENSG00000135334" "AKIRIN2" "hsa:55122; Q53H80; Q9BQB1" "" "" "0" "0" "1.063" "1.002" "1.091" "1.076" "1.074" "0.902" "0.915" "0.910" "1.118" "372.7" "396.0" "373.6" "406.8" "400.9" "400.4" "336.2" "341.2" "339.2" "416.6" "" "" "" "" "" "" "" "" "" "" "299.3" "285.7" "296.8" "272.5" "277.3" "300.4" "235.4" "249.1" "339.2" "338.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485093718878693272" "False" "High" "IsMasterProtein" "P09917" "Polyunsaturated fatty acid 5-lipoxygenase OS=Homo sapiens OX=9606 GN=ALOX5 PE=1 SV=2" "0.000" "False" "16.225" "7" "4" "4" "4" "674" "77.9" "5.77" "12.41" "4" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00305, Pf01477" "240" "ENSG00000012779; ENSG00000275565" "ALOX5" "B7ZLS0; E5FPY5; E5FPY7; E5FPY8; hsa:240; P09917; Q5JQ14" "Neutrophil degranulation; Interleukin-4 and Interleukin-13 signaling; Interleukin-18 signaling; Synthesis of 5-eicosatetraenoic acids; Synthesis of Leukotrienes (LT) and Eoxins (EX); Synthesis of Lipoxins (LX); Biosynthesis of D-series resolvins; Biosynthesis of maresins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins; Biosynthesis of DPAn-3-derived protectins and resolvins; Biosynthesis of DPAn-3-derived maresins; Biosynthesis of DPAn-3-derived 13-series resolvins; Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives" "Selenium micronutrient network; Vitamin D receptor pathway; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; ALA oxylipin metabolism; Linoleic acid oxylipin metabolism; Lipid metabolism in senescent cells; Urotensin-II-mediated signaling pathway; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "26" "0" "0.830" "0.845" "1.260" "0.771" "1.137" "1.283" "1.154" "0.867" "1.088" "35.3" "29.3" "29.8" "44.5" "27.2" "40.1" "45.3" "40.7" "30.6" "38.4" "" "" "" "" "" "" "" "" "" "" "28.3" "21.1" "23.7" "29.8" "18.8" "30.1" "31.7" "29.7" "30.6" "31.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-390863097898701106" "False" "High" "IsMasterProtein" "Q14657" "EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2" "0.000" "False" "16.225" "32" "3" "3" "3" "143" "14.8" "8.63" "9.55" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09341" "8270" "ENSG00000196976" "LAGE3" "hsa:8270; Q14657; Q5HY39; Q8IZ78" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.873" "0.930" "1.078" "1.075" "1.119" "0.969" "1.173" "1.041" "1.186" "65.9" "57.5" "61.3" "71.0" "70.8" "73.7" "63.9" "77.3" "68.6" "78.1" "" "" "" "" "" "" "" "" "" "" "52.9" "41.5" "48.7" "47.6" "49.0" "55.3" "44.7" "56.5" "68.6" "63.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2424139350801194209" "False" "High" "IsMasterProtein" "Q9NRG0" "Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1" "0.000" "False" "16.220" "20" "2" "4" "2" "131" "14.7" "5.10" "15.95" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54108" "ENSG00000104472" "CHRAC1" "hsa:54108; Q9NRG0" "" "Acute viral myocarditis" "1" "0" "1.233" "1.161" "1.104" "0.992" "0.980" "1.094" "0.995" "1.147" "1.157" "258.9" "319.1" "300.7" "285.8" "256.8" "253.8" "283.3" "257.6" "297.0" "299.5" "" "" "" "" "" "" "" "" "" "" "208.0" "230.3" "238.8" "191.5" "177.6" "190.5" "198.3" "188.1" "297.0" "243.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2760060553440129895" "False" "High" "IsMasterProtein" "Q8NDB2" "B-cell scaffold protein with ankyrin repeats OS=Homo sapiens OX=9606 GN=BANK1 PE=1 SV=3" "0.000" "False" "16.213" "5" "3" "3" "3" "785" "89.2" "5.40" "8.83" "3" "signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "55024" "ENSG00000153064" "BANK1" "A8K7W8; B0F3S2; hsa:55024; Q8N5K8; Q8NB56; Q8NDB2; Q8WYN5; Q9NWP2" "" "" "0" "0" "1.035" "0.865" "1.066" "1.019" "0.834" "0.902" "1.041" "0.956" "0.929" "106.1" "109.8" "91.7" "113.0" "108.1" "88.5" "95.7" "110.4" "101.4" "98.6" "" "" "" "" "" "" "" "" "" "" "85.2" "79.2" "72.9" "75.7" "74.8" "66.4" "67.0" "80.6" "101.4" "80.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575198767162097907" "False" "High" "IsMasterProtein" "Q9BXV9" "EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2" "0.000" "False" "16.211" "50" "3" "6" "3" "100" "10.9" "4.27" "24.41" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15387" "84520" "ENSG00000170270; ENSG00000275619" "GON7" "Q0D2N1; Q0P6C4; Q3B7W5; Q9BXV9" "" "" "0" "0" "1.007" "1.145" "1.107" "1.119" "1.054" "1.122" "1.171" "1.004" "1.090" "256.2" "258.1" "293.4" "283.6" "286.8" "270.1" "287.6" "300.0" "257.3" "279.4" "" "" "" "" "" "" "" "" "" "" "205.8" "186.3" "233.1" "190.0" "198.4" "202.7" "201.4" "219.1" "257.3" "227.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219092479354345629" "False" "High" "IsMasterProtein" "O94855" "Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2" "0.000" "False" "16.201" "5" "6" "6" "5" "1032" "112.9" "7.25" "17.95" "6" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9871" "ENSG00000150961" "SEC24D" "hsa:9871; O94855; Q8IYI7" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "1.007" "1.045" "1.030" "0.958" "1.002" "0.959" "0.979" "0.950" "0.992" "595.3" "599.5" "622.2" "613.1" "570.3" "596.2" "571.0" "583.1" "565.6" "590.6" "" "" "" "" "" "" "" "" "" "" "478.2" "432.6" "494.2" "410.8" "394.4" "447.3" "399.8" "425.8" "565.6" "480.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2189358421583622075" "False" "High" "IsMasterProtein" "Q8TCY9" "Up-regulator of cell proliferation OS=Homo sapiens OX=9606 GN=URGCP PE=1 SV=2" "0.000" "False" "16.182" "5" "4" "4" "4" "931" "104.9" "6.42" "12.13" "4" "cell cycle OR cell proliferation" "cytosol;nucleus" "other molecular function" "" "55665" "ENSG00000106608" "URGCP" "E9PFF6; hsa:55665; Q658M4; Q68DH6; Q6MZZ5; Q8TCY9; Q8WV98; Q9NWR7; Q9P221" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2447610796588384838" "False" "High" "IsMasterProtein" "Q96SZ5" "2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2" "0.000" "False" "16.181" "17" "4" "4" "4" "270" "29.7" "6.04" "11.78" "4" "stress response" "cytosol" "other molecular function" "Pf07847" "84890" "ENSG00000181915" "ADO" "B1AL29; hsa:84890; Q96SZ5" "Degradation of cysteine and homocysteine" "" "1" "0" "0.980" "0.900" "1.003" "0.988" "1.119" "1.035" "0.968" "0.989" "1.031" "156.3" "153.3" "140.8" "156.8" "154.4" "174.9" "161.8" "151.2" "154.7" "161.2" "" "" "" "" "" "" "" "" "" "" "125.6" "110.6" "111.8" "105.0" "106.8" "131.2" "113.3" "110.5" "154.7" "131.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277181117143708744" "False" "High" "IsMasterProtein" "P60866" "Small ribosomal subunit protein uS10 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "0.000" "False" "16.148" "33" "4" "9" "4" "119" "13.4" "9.94" "23.00" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.909" "1.110" "1.040" "1.110" "1.024" "1.042" "0.969" "0.981" "1.013" "487.2" "442.6" "540.8" "506.8" "540.7" "498.7" "507.8" "472.3" "478.1" "493.6" "" "" "" "" "" "" "" "" "" "" "391.3" "319.4" "429.6" "339.5" "374.0" "374.2" "355.5" "344.9" "478.1" "401.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7220611050320335909" "False" "High" "IsMasterProtein" "Q8TDH9" "Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Homo sapiens OX=9606 GN=BLOC1S5 PE=1 SV=1" "0.000" "False" "16.136" "21" "4" "4" "4" "187" "21.6" "7.59" "15.53" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "ER/Golgi;other cell component" "" "Pf14942" "63915" "ENSG00000188428" "BLOC1S5" "B4DVM2; hsa:63915; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q8TDH9; Q9NU16" "" "" "0" "0" "1.068" "1.077" "1.136" "1.064" "1.099" "1.032" "1.029" "1.057" "1.059" "608.4" "649.8" "655.5" "690.9" "647.3" "668.8" "627.8" "626.2" "643.0" "644.5" "" "" "" "" "" "" "" "" "" "" "488.6" "468.9" "520.6" "462.9" "447.7" "501.8" "439.6" "457.3" "643.0" "524.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741910088829308609" "False" "High" "IsMasterProtein" "Q9NP66" "High mobility group protein 20A OS=Homo sapiens OX=9606 GN=HMG20A PE=1 SV=1" "0.000" "False" "16.120" "11" "3" "3" "3" "347" "40.1" "6.49" "13.59" "3" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505" "10363" "ENSG00000140382" "HMG20A" "A6NHY3; D3DW78; hsa:10363; Q53G31; Q9NP66; Q9NSF6" "" "" "0" "0" "1.068" "0.904" "0.934" "1.020" "0.925" "0.968" "1.011" "0.909" "0.936" "78.6" "83.9" "71.0" "73.4" "80.2" "72.7" "76.1" "79.4" "71.4" "73.6" "" "" "" "" "" "" "" "" "" "" "63.1" "60.6" "56.4" "49.2" "55.4" "54.5" "53.3" "58.0" "71.4" "59.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7950271419257628424" "False" "High" "IsMasterProtein" "P30049" "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" "0.000" "False" "16.096" "14" "2" "3" "2" "168" "17.5" "5.49" "13.10" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf02823, Pf21335" "513" "ENSG00000099624" "ATP5F1D" "D6W5Y3; hsa:513; P30049; Q6FG90" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "1.001" "0.993" "0.988" "1.102" "0.992" "1.137" "1.043" "0.998" "0.964" "566.9" "567.6" "563.0" "560.3" "624.5" "562.5" "644.6" "591.0" "565.5" "546.2" "" "" "" "" "" "" "" "" "" "" "455.3" "409.5" "447.2" "375.4" "431.9" "422.0" "451.3" "431.6" "565.5" "444.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721497203732723661" "False" "High" "IsMasterProtein" "P01591" "Immunoglobulin J chain OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=4" "0.000" "False" "16.090" "21" "3" "6" "3" "159" "18.1" "5.24" "17.67" "3" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf15097" "3512" "ENSG00000132465" "JCHAIN" "hsa:3512; P01591" "Cell surface interactions at the vascular wall; Scavenging of heme from plasma" "" "2" "0" "1.015" "0.975" "1.095" "1.017" "0.989" "1.042" "1.114" "1.032" "0.984" "520.3" "528.2" "507.4" "569.9" "529.3" "514.8" "542.2" "579.4" "536.8" "512.0" "" "" "" "" "" "" "" "" "" "" "417.9" "381.2" "403.1" "381.9" "366.0" "386.3" "379.6" "423.1" "536.8" "416.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3946386613732823747" "False" "High" "IsMasterProtein" "Q8WXD5" "Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1" "0.000" "False" "16.087" "28" "4" "5" "4" "167" "18.8" "5.12" "17.32" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06372, Pf20417" "79833" "ENSG00000152147" "GEMIN6" "B2RDP8; hsa:79833; Q53SI5; Q8WVB4; Q8WXD5; Q9H5G6" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "" "2" "0" "1.051" "1.082" "1.113" "1.095" "1.134" "1.052" "1.123" "1.063" "1.153" "223.6" "235.0" "241.9" "249.0" "244.9" "253.7" "235.3" "251.1" "237.7" "257.8" "" "" "" "" "" "" "" "" "" "" "179.6" "169.6" "192.1" "166.8" "169.4" "190.3" "164.8" "183.4" "237.7" "209.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2670793063602377093" "False" "High" "IsMasterProtein" "Q8TBZ6" "tRNA methyltransferase 10 homolog A OS=Homo sapiens OX=9606 GN=TRMT10A PE=1 SV=1" "0.000" "False" "16.076" "13" "4" "6" "4" "339" "39.7" "7.65" "11.15" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01746" "93587" "ENSG00000145331" "TRMT10A" "B2R8X7; hsa:93587; Q8TBZ6; Q9Y2T9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.956" "0.962" "0.940" "0.990" "0.982" "0.938" "0.947" "1.068" "0.968" "302.8" "289.5" "291.3" "284.5" "299.7" "297.2" "284.1" "286.7" "323.3" "293.1" "" "" "" "" "" "" "" "" "" "" "243.2" "208.9" "231.4" "190.6" "207.3" "223.0" "198.9" "209.4" "323.3" "238.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2956258532807354033" "False" "High" "IsMasterProtein" "O00459" "Phosphatidylinositol 3-kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PIK3R2 PE=1 SV=2" "0.000" "False" "16.075" "5" "4" "5" "2" "728" "81.5" "6.43" "14.77" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5296" "ENSG00000105647" "PIK3R2" "hsa:5296; O00459; Q5EAT5; Q9UPH9" "Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "113" "0" "1.022" "1.050" "0.889" "1.019" "1.051" "0.877" "0.962" "0.960" "1.060" "272.7" "278.7" "286.4" "242.4" "277.9" "286.5" "239.2" "262.3" "261.9" "289.0" "" "" "" "" "" "" "" "" "" "" "219.0" "201.1" "227.5" "162.4" "192.2" "215.0" "167.5" "191.6" "261.9" "235.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6163739139500016116" "False" "High" "IsMasterProtein" "Q9BSQ5" "Cerebral cavernous malformations 2 protein OS=Homo sapiens OX=9606 GN=CCM2 PE=1 SV=1" "0.000" "False" "16.059" "9" "3" "3" "3" "444" "48.8" "5.54" "11.85" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion;other cell component" "" "Pf16545" "83605" "ENSG00000136280" "CCM2" "A4D2L4; B3KUV0; D3DVL4; E9PDJ3; F5H0E1; F5H551; hsa:83605; Q71RE5; Q8TAT4; Q9BSQ5" "" "" "0" "0" "0.986" "1.005" "1.007" "0.968" "0.994" "0.953" "1.010" "1.067" "1.020" "372.6" "367.3" "374.3" "375.2" "360.9" "370.3" "355.2" "376.5" "397.5" "380.1" "" "" "" "" "" "" "" "" "" "" "299.3" "265.0" "297.3" "251.4" "249.6" "277.8" "248.7" "275.0" "397.5" "309.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8819543894453362776" "False" "High" "IsMasterProtein" "Q96DA2" "Ras-related protein Rab-39B OS=Homo sapiens OX=9606 GN=RAB39B PE=1 SV=1" "0.000" "False" "16.034" "16" "3" "7" "2" "213" "24.6" "7.83" "23.94" "3" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "116442" "ENSG00000155961" "RAB39B" "hsa:116442; Q5JT79; Q8NEX3; Q96DA2" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "" "2" "0" "1.033" "1.162" "1.259" "1.175" "1.142" "1.366" "1.126" "1.071" "1.174" "28.0" "29.0" "32.6" "35.3" "33.0" "32.0" "38.3" "31.6" "30.0" "32.9" "" "" "" "" "" "" "" "" "" "" "22.5" "20.9" "25.9" "23.7" "22.8" "24.0" "26.8" "23.1" "30.0" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5958960994699696402" "False" "High" "IsMasterProtein" "Q99081" "Transcription factor 12 OS=Homo sapiens OX=9606 GN=TCF12 PE=1 SV=1" "0.000" "False" "16.030" "9" "4" "4" "4" "682" "72.9" "7.02" "9.64" "4" "other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6938" "ENSG00000140262" "TCF12" "B4E1W1; hsa:6938; Q7Z3D9; Q86TC1; Q86VM2; Q99081" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; NGF-stimulated transcription; Myogenesis" "" "3" "0" "1.291" "1.476" "1.538" "1.818" "1.563" "1.466" "1.447" "1.124" "1.473" "15.9" "20.5" "23.4" "24.4" "28.9" "24.8" "23.3" "23.0" "17.9" "23.4" "" "" "" "" "" "" "" "" "" "" "12.8" "14.8" "18.6" "16.4" "20.0" "18.6" "16.3" "16.8" "17.9" "19.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9082551203190853772" "False" "High" "IsMasterProtein" "Q16777" "Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=H2AC20 PE=1 SV=4" "0.000" "False" "16.010" "33" "4" "9" "1" "129" "14.0" "10.90" "25.17" "4" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "8338" "ENSG00000184260" "H2AC20" "hsa:8338; Q16777; Q6DRA7; Q8IUE5" "Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ub-specific processing proteases; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Metalloprotease DUBs; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "" "42" "0" "0.859" "0.993" "1.267" "1.060" "0.907" "1.089" "0.833" "0.894" "0.934" "135.7" "116.5" "134.8" "172.0" "143.9" "123.1" "147.8" "113.0" "121.3" "126.7" "" "" "" "" "" "" "" "" "" "" "109.0" "84.1" "107.1" "115.2" "99.5" "92.4" "103.4" "82.6" "121.3" "103.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1908933075179858623" "False" "High" "IsMasterProtein" "Cont_A2I7N3" "Serpin A3-7 OS=Bos taurus OX=9913 GN=SERPINA3-7 PE=3 SV=1" "0.000" "True" "16.006" "10" "4" "5" "3" "417" "46.9" "6.34" "15.69" "4" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "" "" "SERPINA3-7" "A2I7N3" "" "" "0" "0" "1.661" "0.851" "1.329" "1.067" "1.345" "1.417" "0.918" "1.080" "1.041" "250.2" "415.7" "213.0" "332.7" "267.1" "336.6" "354.6" "229.8" "270.2" "260.6" "" "" "" "" "" "" "" "" "" "" "201.0" "299.9" "169.2" "222.9" "184.8" "252.5" "248.3" "167.8" "270.2" "211.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8365125981762301712" "False" "High" "IsMasterProtein" "P52739" "Zinc finger protein 131 OS=Homo sapiens OX=9606 GN=ZNF131 PE=1 SV=2" "0.000" "False" "15.986" "7" "3" "4" "3" "623" "71.4" "5.19" "14.18" "3" "other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00651, Pf12874" "7690" "ENSG00000172262" "ZNF131" "B4DRL3; hsa:7690; P52739; Q6PIF0" "SUMOylation of transcription cofactors" "" "1" "0" "0.998" "0.941" "0.937" "0.956" "1.067" "1.039" "1.012" "1.048" "1.022" "236.7" "236.2" "222.8" "221.7" "226.3" "252.5" "245.9" "239.5" "248.1" "241.8" "" "" "" "" "" "" "" "" "" "" "190.1" "170.5" "177.0" "148.6" "156.5" "189.4" "172.1" "174.9" "248.1" "196.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7682312476163043373" "False" "High" "IsMasterProtein" "P82914" "Small ribosomal subunit protein uS15m OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1" "0.000" "False" "15.976" "21" "6" "7" "6" "257" "29.8" "10.48" "20.83" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00312" "64960" "ENSG00000116898" "MRPS15" "B2RD82; hsa:64960; P82914; Q9H2K1" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.021" "0.999" "0.992" "0.916" "0.964" "0.916" "1.030" "1.016" "0.998" "802.3" "818.9" "801.4" "795.9" "735.0" "773.8" "735.2" "826.1" "814.8" "800.8" "" "" "" "" "" "" "" "" "" "" "644.4" "590.9" "636.6" "533.2" "508.3" "580.5" "514.7" "603.3" "814.8" "651.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5200197799913832465" "False" "High" "IsMasterProtein" "C9J798" "Ras GTPase-activating protein 4B OS=Homo sapiens OX=9606 GN=RASA4B PE=1 SV=2" "0.000" "False" "15.960" "7" "5" "5" "5" "803" "90.4" "7.74" "12.48" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "" "ENSG00000170667" "RASA4B" "C9J798" "" "Ras signaling" "1" "0" "0.898" "1.033" "0.808" "0.887" "1.109" "1.052" "1.017" "1.095" "1.063" "67.1" "60.2" "69.3" "54.2" "59.5" "74.4" "70.5" "68.2" "73.5" "71.3" "" "" "" "" "" "" "" "" "" "" "53.9" "43.4" "55.1" "36.3" "41.2" "55.8" "49.4" "49.8" "73.5" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4664768508757263066" "False" "High" "IsMasterProtein" "Q15527" "Surfeit locus protein 2 OS=Homo sapiens OX=9606 GN=SURF2 PE=1 SV=4" "0.000" "False" "15.938" "12" "2" "3" "2" "256" "29.6" "9.22" "7.94" "2" "" "plasma membrane;other membranes;nucleus" "" "Pf05477" "6835" "ENSG00000148291; ENSG00000281024" "SURF2" "hsa:6835; Q15527; Q6IBP9; Q96CD1" "" "" "0" "0" "1.113" "0.918" "0.958" "1.049" "1.191" "1.137" "1.143" "0.959" "1.132" "121.0" "134.6" "111.0" "115.9" "126.9" "144.1" "137.5" "138.2" "116.0" "136.9" "" "" "" "" "" "" "" "" "" "" "97.1" "97.1" "88.2" "77.6" "87.8" "108.1" "96.3" "101.0" "116.0" "111.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5123694492544734526" "False" "High" "IsMasterProtein" "Q99417" "c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3" "0.000" "False" "15.913" "20" "3" "6" "3" "103" "12.0" "5.91" "20.67" "3" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "" "26292" "ENSG00000214114" "MYCBP" "B2R4N0; hsa:26292; Q5TA64; Q96HE2; Q99417" "" "Pathways affected in adenoid cystic carcinoma" "1" "0" "1.127" "1.044" "1.018" "0.975" "1.041" "0.925" "0.967" "0.965" "0.974" "991.9" "1117.6" "1035.9" "1009.3" "967.1" "1032.5" "917.2" "958.7" "956.9" "966.4" "" "" "" "" "" "" "" "" "" "" "796.7" "806.5" "822.9" "676.2" "668.9" "774.7" "642.2" "700.1" "956.9" "785.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3879752315455634749" "False" "High" "IsMasterProtein" "O43822" "Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1" "0.000" "False" "15.904" "14" "3" "3" "3" "256" "28.3" "7.34" "10.30" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "" "" "755" "ENSG00000160226" "CFAP410" "A8MPS9; O14993; O43822; Q8N5X6; Q99837; Q99838" "" "Ciliopathies; Bardet-Biedl syndrome" "2" "0" "0.945" "0.942" "0.884" "0.994" "1.006" "1.022" "1.021" "1.023" "0.959" "184.9" "174.7" "174.3" "163.4" "183.8" "186.1" "188.9" "188.7" "189.1" "177.3" "" "" "" "" "" "" "" "" "" "" "148.5" "126.1" "138.4" "109.5" "127.1" "139.6" "132.3" "137.8" "189.1" "144.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2135832377467312061" "False" "High" "IsMasterProtein" "Q9UHC7" "E3 ubiquitin-protein ligase makorin-1 OS=Homo sapiens OX=9606 GN=MKRN1 PE=1 SV=3" "0.000" "False" "15.891" "10" "3" "3" "3" "482" "53.3" "5.14" "10.12" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00097, Pf14608, Pf15815, Pf18044" "23608" "ENSG00000133606" "MKRN1" "A4D1T7; B3KXB4; Q256Y7; Q59G11; Q6GSF1; Q9H0G0; Q9UEZ7; Q9UHC7; Q9UHW2" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; AKT phosphorylates targets in the cytosol" "" "3" "0" "1.179" "1.078" "1.108" "0.991" "1.139" "1.128" "0.917" "1.216" "1.056" "105.6" "124.5" "113.8" "117.0" "104.7" "120.3" "119.1" "96.8" "128.4" "111.5" "" "" "" "" "" "" "" "" "" "" "84.8" "89.8" "90.4" "78.4" "72.4" "90.3" "83.4" "70.7" "128.4" "90.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3981645766527825606" "False" "High" "IsMasterProtein" "Q9HC98" "Serine/threonine-protein kinase Nek6 OS=Homo sapiens OX=9606 GN=NEK6 PE=1 SV=2" "0.000" "False" "15.881" "13" "4" "4" "4" "313" "35.7" "8.03" "11.77" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "10783" "ENSG00000119408" "NEK6" "B7Z2D9; hsa:10783; Q5TBG3; Q5TBG9; Q6FG86; Q6IAR3; Q96E83; Q9HC98; Q9ULX2" "Nuclear Pore Complex (NPC) Disassembly; EML4 and NUDC in mitotic spindle formation; Activation of NIMA Kinases NEK9, NEK6, NEK7" "" "3" "0" "1.098" "1.060" "0.935" "0.924" "1.020" "0.873" "0.873" "0.941" "0.996" "412.5" "452.9" "437.2" "385.6" "381.1" "420.9" "360.0" "360.1" "388.3" "411.0" "" "" "" "" "" "" "" "" "" "" "331.3" "326.8" "347.3" "258.3" "263.6" "315.8" "252.1" "263.0" "388.3" "334.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699158399968223668" "False" "High" "IsMasterProtein" "Q15311" "RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3" "0.000" "False" "15.835" "8" "6" "7" "6" "655" "76.0" "5.88" "17.55" "6" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus" "transporter activity;enzyme regulator activity;other molecular function" "Pf00620, Pf20924" "10928" "ENSG00000017797" "RALBP1" "D3DUI0; hsa:10928; Q15311" "RAC1 GTPase cycle; CDC42 GTPase cycle" "RalA downstream regulated genes; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "6" "0" "1.037" "0.993" "1.030" "1.000" "0.979" "0.988" "0.891" "1.062" "0.963" "808.4" "838.5" "802.4" "832.5" "808.6" "791.1" "798.7" "720.0" "858.7" "778.5" "" "" "" "" "" "" "" "" "" "" "649.3" "605.0" "637.4" "557.8" "559.2" "593.6" "559.2" "525.8" "858.7" "633.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8173179408617438185" "False" "High" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "0.000" "False" "15.825" "9" "3" "3" "3" "405" "44.5" "6.70" "13.07" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "12" "0" "0.985" "1.185" "0.833" "0.929" "1.029" "1.026" "1.254" "1.143" "1.102" "63.9" "62.9" "75.7" "53.2" "59.4" "65.7" "65.6" "80.1" "73.1" "70.4" "" "" "" "" "" "" "" "" "" "" "51.3" "45.4" "60.2" "35.7" "41.1" "49.3" "45.9" "58.5" "73.1" "57.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6707241685728679125" "False" "High" "IsMasterProtein" "Q9NY93" "Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens OX=9606 GN=DDX56 PE=1 SV=1" "0.000" "False" "15.806" "6" "3" "3" "3" "547" "61.6" "9.26" "10.67" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54606" "ENSG00000136271" "DDX56" "A4D2K9; C9JV95; hsa:54606; Q6IAE2; Q9H9I8; Q9NY93" "" "" "0" "0" "1.204" "1.173" "1.269" "1.279" "1.045" "1.101" "1.124" "1.188" "1.169" "220.3" "265.1" "258.3" "279.6" "281.7" "230.1" "242.5" "247.5" "261.8" "257.5" "" "" "" "" "" "" "" "" "" "" "176.9" "191.3" "205.2" "187.4" "194.8" "172.6" "169.8" "180.8" "261.8" "209.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "247879969936268411" "False" "High" "IsMasterProtein" "O94992" "Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1" "0.000" "False" "15.781" "13" "5" "6" "4" "359" "40.6" "4.89" "15.91" "5" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "10614" "ENSG00000186834" "HEXIM1" "B2R8Y5; hsa:10614; O94992" "" "Initiation of transcription and translation elongation at the HIV-1 LTR" "1" "1" "0.994" "0.908" "1.151" "1.040" "0.988" "1.064" "1.026" "1.056" "1.100" "223.0" "221.7" "202.5" "256.7" "231.8" "220.4" "237.2" "228.9" "235.6" "245.3" "" "" "" "" "" "" "" "" "" "" "179.1" "160.0" "160.8" "172.0" "160.3" "165.4" "166.1" "167.2" "235.6" "199.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7251340200107887376" "False" "High" "IsMasterProtein" "Q6P9B9" "Integrator complex subunit 5 OS=Homo sapiens OX=9606 GN=INTS5 PE=1 SV=1" "0.000" "False" "15.780" "5" "5" "5" "5" "1019" "107.9" "7.05" "15.98" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "" "Pf14837, Pf14838" "80789" "ENSG00000185085" "INTS5" "hsa:80789; Q6P9B9; Q8N6W5; Q9C0G5" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.062" "0.995" "1.018" "0.961" "1.039" "1.031" "0.973" "0.963" "1.054" "422.1" "448.2" "419.9" "429.8" "405.7" "438.6" "435.3" "410.7" "406.6" "444.9" "" "" "" "" "" "" "" "" "" "" "339.0" "323.4" "333.5" "288.0" "280.6" "329.1" "304.8" "299.9" "406.6" "361.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308881138529098641" "False" "High" "IsMasterProtein" "Q9Y244" "Proteasome maturation protein OS=Homo sapiens OX=9606 GN=POMP PE=1 SV=1" "0.000" "False" "15.768" "35" "4" "5" "4" "141" "15.8" "5.11" "20.09" "4" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf05348" "51371" "ENSG00000132963" "POMP" "A5HKJ2; D6MXU3; hsa:51371; Q9HB69; Q9Y244" "" "" "0" "0" "0.942" "0.712" "0.824" "0.913" "0.846" "0.843" "0.869" "0.866" "0.835" "45.5" "42.9" "32.4" "37.5" "41.6" "38.5" "38.4" "39.6" "39.4" "38.0" "" "" "" "" "" "" "" "" "" "" "36.6" "30.9" "25.7" "25.1" "28.8" "28.9" "26.9" "28.9" "39.4" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "844941694654797990" "False" "High" "IsMasterProtein" "P14923" "Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3" "0.000" "False" "15.749" "8" "4" "5" "4" "745" "81.7" "6.14" "13.98" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00514" "3728" "ENSG00000173801" "JUP" "hsa:3728; P14923; Q15093; Q15151; Q7L3S5; Q86W21; Q9BWC4; Q9HCX9" "Neutrophil degranulation; Formation of the cornified envelope; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions; RHOH GTPase cycle" "Arrhythmogenic right ventricular cardiomyopathy; Corticotropin-releasing hormone signaling pathway; Ectoderm differentiation; Ectoderm differentiation; Epithelial to mesenchymal transition in colorectal cancer; Opioid receptor pathways; Acute myeloid leukemia" "22" "0" "0.623" "0.271" "0.354" "0.447" "0.536" "1.146" "0.495" "0.526" "0.671" "291.9" "181.8" "79.1" "103.2" "130.5" "156.6" "334.4" "144.6" "153.7" "195.9" "" "" "" "" "" "" "" "" "" "" "234.4" "131.2" "62.8" "69.2" "90.3" "117.5" "234.1" "105.6" "153.7" "159.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3469585503029869905" "False" "High" "IsMasterProtein" "Q96PU5" "E3 ubiquitin-protein ligase NEDD4-like OS=Homo sapiens OX=9606 GN=NEDD4L PE=1 SV=2" "0.000" "False" "15.741" "5" "5" "5" "5" "975" "111.9" "5.82" "14.97" "5" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf00397, Pf00632" "23327" "ENSG00000049759" "NEDD4L" "hsa:23327; O43165; Q3LSM7; Q7Z5F1; Q7Z5F2; Q7Z5N3; Q8N5A7; Q8WUU9; Q96PU5; Q9BW58; Q9H2W4; Q9NT88" "Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Stimuli-sensing channels; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "TGF-beta signaling pathway" "6" "0" "1.005" "0.995" "1.014" "0.897" "0.960" "0.947" "0.897" "1.005" "0.988" "546.2" "548.7" "543.6" "554.1" "489.8" "524.4" "517.1" "490.1" "548.9" "539.6" "" "" "" "" "" "" "" "" "" "" "438.7" "395.9" "431.8" "371.2" "338.7" "393.5" "362.1" "357.9" "548.9" "438.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8350052096889729945" "False" "High" "IsMasterProtein" "O95670" "V-type proton ATPase subunit G 2 OS=Homo sapiens OX=9606 GN=ATP6V1G2 PE=1 SV=1" "0.000" "False" "15.708" "32" "3" "3" "3" "118" "13.6" "10.26" "9.14" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "534" "ENSG00000206445; ENSG00000213760; ENSG00000226850; ENSG00000227587; ENSG00000230900; ENSG00000234668; ENSG00000234920" "ATP6V1G2" "B5MEF0; hsa:534; O95670; Q2L6F8; Q5HYU8; Q5RJ63" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "" "5" "0" "0.977" "0.842" "1.234" "1.220" "0.943" "1.107" "1.078" "1.022" "1.077" "102.3" "99.9" "86.1" "126.3" "124.9" "96.5" "113.3" "110.3" "104.6" "110.2" "" "" "" "" "" "" "" "" "" "" "82.2" "72.1" "68.4" "84.6" "86.4" "72.4" "79.3" "80.5" "104.6" "89.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "916743004623214960" "False" "High" "IsMasterProtein" "P62266" "Small ribosomal subunit protein uS12 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "0.000" "False" "15.699" "14" "3" "3" "3" "143" "15.8" "10.49" "12.57" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK4 (GCN2) to amino acid deficiency; Protein hydroxylation; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "1.068" "1.172" "1.175" "1.117" "1.102" "1.205" "1.138" "1.203" "1.101" "323.7" "345.8" "379.5" "380.4" "361.6" "356.7" "390.3" "368.3" "389.5" "356.6" "" "" "" "" "" "" "" "" "" "" "260.0" "249.5" "301.5" "254.8" "250.1" "267.7" "273.2" "269.0" "389.5" "290.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250154090209623680" "False" "High" "IsMasterProtein" "Q9H2W6" "Large ribosomal subunit protein mL46 OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "0.000" "False" "15.669" "18" "5" "7" "5" "279" "31.7" "7.05" "23.45" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.949" "0.937" "0.975" "0.897" "0.941" "0.925" "0.879" "0.881" "0.940" "494.0" "468.7" "462.8" "481.6" "443.3" "464.8" "457.2" "434.1" "435.5" "464.4" "" "" "" "" "" "" "" "" "" "" "396.8" "338.2" "367.6" "322.6" "306.6" "348.7" "320.1" "317.0" "435.5" "377.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "846923677132301137" "False" "High" "IsMasterProtein" "Q9UBS8" "E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens OX=9606 GN=RNF14 PE=1 SV=1" "0.000" "False" "15.667" "9" "4" "4" "4" "474" "53.8" "4.75" "15.02" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01485, Pf05773" "9604" "ENSG00000013561" "RNF14" "A0AV26; A6NMR2; A8MTW5; B3KN72; B7ZLV2; D3DQE4; hsa:9604; O94793; Q6IBV0; Q9UBS8" "Antigen processing: Ubiquitination & Proteasome degradation" "Androgen receptor signaling pathway" "2" "0" "1.005" "0.999" "0.873" "0.995" "1.015" "0.920" "0.995" "0.974" "0.888" "247.0" "248.3" "246.7" "215.6" "245.6" "250.8" "227.2" "245.6" "240.6" "219.3" "" "" "" "" "" "" "" "" "" "" "198.4" "179.1" "196.0" "144.5" "169.9" "188.2" "159.1" "179.4" "240.6" "178.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2639971144615305775" "False" "High" "IsMasterProtein" "Q9Y592" "Centrosomal protein of 83 kDa OS=Homo sapiens OX=9606 GN=CEP83 PE=1 SV=3" "0.000" "False" "15.656" "9" "6" "6" "6" "701" "82.9" "6.20" "11.47" "6" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "" "51134" "ENSG00000173588" "CEP83" "A4FVB1; hsa:51134; Q08AP1; Q9Y592" "Anchoring of the basal body to the plasma membrane" "Genes related to primary cilium development (based on CRISPR); Ciliopathies" "3" "0" "1.109" "0.989" "1.203" "1.148" "0.985" "1.185" "1.138" "1.045" "1.066" "250.3" "277.7" "247.5" "301.0" "287.3" "246.7" "296.6" "284.8" "261.4" "266.7" "" "" "" "" "" "" "" "" "" "" "201.0" "200.4" "196.6" "201.7" "198.7" "185.1" "207.7" "208.0" "261.4" "216.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2771631356277906494" "False" "High" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "0.000" "False" "15.645" "6" "2" "4" "2" "507" "55.0" "7.72" "10.55" "2" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Basigin interactions; Tryptophan catabolism; Amino acid transport across the plasma membrane" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "7" "0" "1.007" "1.162" "0.835" "1.133" "1.630" "1.248" "1.230" "1.100" "0.928" "25.1" "25.3" "29.2" "21.0" "28.5" "41.0" "31.4" "30.9" "27.6" "23.3" "" "" "" "" "" "" "" "" "" "" "20.2" "18.3" "23.2" "14.1" "19.7" "30.7" "22.0" "22.6" "27.6" "19.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-932703795777546839" "False" "High" "IsMasterProtein" "Q96BJ3" "Axin interactor, dorsalization-associated protein OS=Homo sapiens OX=9606 GN=AIDA PE=1 SV=1" "0.000" "False" "15.609" "15" "4" "5" "4" "306" "35.0" "6.55" "12.83" "4" "developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf08910, Pf14186" "64853" "ENSG00000186063" "AIDA" "A8K1F0; hsa:64853; Q49A81; Q5JRA4; Q658P1; Q96BJ3; Q9H9E8" "" "" "0" "0" "0.947" "0.935" "1.064" "0.914" "0.982" "1.021" "0.981" "1.011" "0.974" "199.5" "188.9" "186.6" "212.4" "182.3" "195.9" "203.7" "195.7" "201.7" "194.4" "" "" "" "" "" "" "" "" "" "" "160.3" "136.3" "148.2" "142.3" "126.1" "147.0" "142.6" "142.9" "201.7" "158.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-631503824976752333" "False" "High" "IsMasterProtein" "Q9BYD2" "Large ribosomal subunit protein bL9m OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2" "0.000" "False" "15.596" "16" "4" "5" "4" "267" "30.2" "10.08" "18.55" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01281" "65005" "ENSG00000143436" "MRPL9" "B2RD99; hsa:65005; Q5SZR2; Q9BSW8; Q9BYD2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.036" "0.942" "1.090" "1.006" "0.922" "1.000" "0.960" "0.920" "0.990" "434.1" "449.5" "408.8" "473.1" "436.9" "400.3" "433.9" "416.5" "399.5" "429.8" "" "" "" "" "" "" "" "" "" "" "348.7" "324.4" "324.7" "317.0" "302.2" "300.3" "303.8" "304.2" "399.5" "349.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8205136122998856932" "False" "High" "IsMasterProtein" "P60981" "Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3" "0.000" "False" "15.591" "16" "2" "3" "2" "165" "18.5" "7.85" "9.14" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00241" "11034" "ENSG00000125868" "DSTN" "B2R6N2; B4DYA6; hsa:11034; P18282; P60981; Q5W166; Q6IAW2" "" "Androgen receptor signaling pathway" "1" "0" "1.064" "1.079" "1.030" "1.113" "1.052" "0.887" "1.042" "0.964" "1.003" "274.4" "292.0" "296.1" "282.5" "305.4" "288.7" "243.4" "285.8" "264.6" "275.3" "" "" "" "" "" "" "" "" "" "" "220.4" "210.7" "235.2" "189.3" "211.2" "216.6" "170.4" "208.7" "264.6" "223.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "577500699946211837" "False" "High" "IsMasterProtein" "Q8NFQ8" "Torsin-1A-interacting protein 2 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1" "0.000" "False" "15.587" "6" "2" "2" "2" "470" "51.2" "4.96" "9.64" "2" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf05609, Pf20443" "163590" "ENSG00000169905" "TOR1AIP2" "hsa:163590; Q8NFQ8" "" "" "0" "0" "0.964" "0.980" "1.044" "1.066" "1.208" "1.088" "1.067" "1.168" "1.036" "198.4" "191.2" "194.4" "207.2" "211.5" "239.6" "215.8" "211.6" "231.7" "205.6" "" "" "" "" "" "" "" "" "" "" "159.3" "137.9" "154.4" "138.8" "146.3" "179.8" "151.1" "154.5" "231.7" "167.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062207759292809652" "False" "High" "IsMasterProtein" "Q13191" "E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens OX=9606 GN=CBLB PE=1 SV=2" "0.000" "False" "15.553" "3" "2" "2" "1" "982" "109.4" "7.88" "8.98" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02262, Pf02761, Pf02762" "868" "ENSG00000114423" "CBLB" "A8K9S7; B7WNM4; Q13191; Q13192; Q13193; Q3LIC0; Q63Z43; Q8IVC5" "Antigen processing: Ubiquitination & Proteasome degradation" "Angiopoietin-like protein 8 regulatory pathway; Fibrin complement receptor 3 signaling pathway; EGF/EGFR signaling pathway; Measles virus infection; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor signaling pathway" "9" "0" "1.312" "1.267" "1.283" "0.946" "0.886" "1.352" "1.233" "0.974" "1.143" "27.0" "35.4" "34.2" "34.6" "25.5" "23.9" "36.5" "33.3" "26.3" "30.8" "" "" "" "" "" "" "" "" "" "" "21.7" "25.5" "27.2" "23.2" "17.6" "17.9" "25.5" "24.3" "26.3" "25.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5673730343044781282" "False" "High" "IsMasterProtein" "Q96HS1" "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" "0.000" "False" "15.543" "9" "4" "7" "4" "289" "32.0" "8.68" "19.74" "4" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;other molecular function" "Pf00300" "192111" "ENSG00000247077" "PGAM5" "A9LN06; C9IZY7; hsa:192111; Q96HS1; Q96JB0" "" "NRF2-ARE regulation" "1" "0" "0.933" "0.970" "1.205" "1.138" "1.129" "1.032" "0.836" "1.059" "0.965" "118.1" "110.2" "114.6" "142.4" "134.4" "133.4" "121.9" "98.8" "125.1" "114.0" "" "" "" "" "" "" "" "" "" "" "94.9" "79.5" "91.0" "95.4" "93.0" "100.1" "85.4" "72.2" "125.1" "92.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6090154179084716209" "False" "High" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "0.000" "False" "15.521" "14" "5" "5" "5" "454" "50.1" "8.25" "16.23" "5" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "1.011" "1.032" "1.045" "0.920" "0.964" "0.965" "0.929" "1.097" "1.181" "97.8" "98.8" "100.9" "102.1" "90.0" "94.3" "94.4" "90.9" "107.2" "115.4" "" "" "" "" "" "" "" "" "" "" "78.5" "71.3" "80.1" "68.4" "62.2" "70.7" "66.1" "66.3" "107.2" "93.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7603913648578901731" "False" "High" "IsMasterProtein" "Q5VWZ2" "Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3" "0.000" "False" "15.516" "22" "5" "8" "5" "237" "26.3" "7.84" "25.00" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02230" "127018" "ENSG00000143353" "LYPLAL1" "A8K677; hsa:127018; Q5VWZ2; Q5VWZ3; Q7Z4A3; Q96AV0" "" "" "0" "0" "1.092" "1.065" "1.034" "1.084" "1.032" "1.037" "1.032" "0.976" "1.071" "583.7" "637.2" "621.7" "603.6" "632.6" "602.1" "605.6" "602.3" "569.6" "625.4" "" "" "" "" "" "" "" "" "" "" "468.8" "459.8" "493.8" "404.4" "437.5" "451.7" "424.0" "439.9" "569.6" "508.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5927147573331767092" "False" "High" "IsMasterProtein" "Q9P0U3" "Sentrin-specific protease 1 OS=Homo sapiens OX=9606 GN=SENP1 PE=1 SV=2" "0.000" "False" "15.485" "6" "3" "4" "3" "644" "73.4" "8.47" "12.87" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf02902" "29843" "ENSG00000079387" "SENP1" "A8K7P5; hsa:29843; Q86XC8; Q9P0U3" "SUMO is proteolytically processed; RHOF GTPase cycle" "" "2" "0" "1.123" "1.095" "1.025" "1.156" "1.095" "1.076" "1.147" "1.249" "1.041" "88.4" "99.2" "96.8" "90.6" "102.2" "96.7" "95.1" "101.4" "110.4" "92.0" "" "" "" "" "" "" "" "" "" "" "71.0" "71.6" "76.9" "60.7" "70.7" "72.6" "66.6" "74.0" "110.4" "74.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-123895126992999128" "False" "High" "IsMasterProtein" "Q96BR5" "Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2" "0.000" "False" "15.464" "17" "4" "4" "4" "231" "25.7" "6.02" "13.77" "4" "" "mitochondrion;nucleus" "" "Pf08238" "65260" "ENSG00000162377" "COA7" "hsa:65260; Q0P6I7; Q96BR5; Q9H9Z9" "" "" "0" "0" "1.197" "1.092" "1.199" "1.080" "1.110" "1.109" "1.102" "1.051" "1.074" "204.2" "244.5" "223.0" "244.8" "220.5" "226.6" "226.5" "225.0" "214.6" "219.3" "" "" "" "" "" "" "" "" "" "" "164.0" "176.4" "177.2" "164.0" "152.5" "170.0" "158.6" "164.3" "214.6" "178.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694143023947037177" "False" "High" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "0.000" "False" "15.458" "16" "7" "8" "7" "445" "48.1" "7.12" "14.36" "7" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "Selenium metabolism and selenoproteins; 2q37 copy number variation syndrome" "3" "0" "1.058" "0.982" "1.075" "1.079" "1.005" "1.019" "1.051" "0.986" "1.102" "270.0" "285.5" "265.2" "290.3" "291.4" "271.4" "275.0" "283.8" "266.3" "297.4" "" "" "" "" "" "" "" "" "" "" "216.8" "206.0" "210.7" "194.5" "201.5" "203.6" "192.6" "207.3" "266.3" "241.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6888861531159930886" "False" "High" "IsMasterProtein" "Q9H832" "Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2" "0.000" "False" "15.435" "11" "3" "3" "3" "354" "38.2" "5.62" "13.96" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00179" "65264" "ENSG00000159202" "UBE2Z" "A6N8M6; A6NC60; hsa:65264; Q7L354; Q8TCM4; Q9H832; Q9H893" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "" "2" "0" "1.010" "1.112" "0.982" "1.327" "1.149" "1.028" "1.061" "1.209" "1.193" "79.0" "79.8" "87.8" "77.6" "104.8" "90.8" "81.2" "83.8" "95.5" "94.2" "" "" "" "" "" "" "" "" "" "" "63.4" "57.6" "69.7" "52.0" "72.5" "68.1" "56.8" "61.2" "95.5" "76.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652692427915398655" "False" "High" "IsMasterProtein" "Q9H0H5" "Rac GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RACGAP1 PE=1 SV=1" "0.000" "False" "15.435" "9" "7" "9" "7" "632" "71.0" "8.88" "23.24" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00130, Pf00620" "29127" "ENSG00000161800" "RACGAP1" "hsa:29127; Q6PJ26; Q9H0H5; Q9NWN2; Q9P250; Q9P2W2" "RHOC GTPase cycle; RHOA GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; RHOB GTPase cycle" "S1P receptor signal transduction; Wnt signaling pathway and pluripotency" "13" "0" "1.045" "0.937" "0.995" "1.011" "1.007" "1.068" "1.162" "1.146" "1.187" "287.2" "300.1" "269.0" "285.8" "290.5" "289.3" "306.7" "333.9" "329.2" "340.8" "" "" "" "" "" "" "" "" "" "" "230.7" "216.5" "213.7" "191.5" "200.9" "217.1" "214.7" "243.8" "329.2" "277.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5438538710980627953" "False" "High" "IsMasterProtein" "Q9H2C0" "Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1" "0.000" "False" "15.415" "8" "4" "5" "4" "597" "67.6" "5.85" "13.24" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "" "Pf00651, Pf01344, Pf07707" "8139" "ENSG00000261609" "GAN" "hsa:8139; Q9H2C0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.826" "0.881" "0.923" "0.979" "1.086" "1.065" "1.053" "1.122" "1.022" "78.5" "64.8" "69.2" "72.4" "76.8" "85.3" "83.6" "82.7" "88.1" "80.2" "" "" "" "" "" "" "" "" "" "" "63.0" "46.8" "54.9" "48.5" "53.1" "64.0" "58.5" "60.4" "88.1" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8273844760254515053" "False" "High" "IsMasterProtein" "Q96QE3" "ATPase family AAA domain-containing protein 5 OS=Homo sapiens OX=9606 GN=ATAD5 PE=1 SV=4" "0.000" "False" "15.412" "3" "5" "5" "5" "1844" "207.4" "9.19" "14.33" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004" "79915" "ENSG00000176208" "ATAD5" "hsa:79915; Q05DH0; Q69YR6; Q96QE3; Q9H9I1" "" "NF1 copy number variation syndrome" "1" "0" "1.037" "1.161" "1.083" "1.002" "1.260" "1.194" "1.112" "1.249" "1.052" "124.6" "129.3" "144.6" "134.9" "124.8" "157.0" "148.8" "138.6" "155.6" "131.1" "" "" "" "" "" "" "" "" "" "" "100.1" "93.3" "114.9" "90.4" "86.3" "117.8" "104.2" "101.2" "155.6" "106.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1443587214663370681" "False" "High" "IsMasterProtein" "Q9UKD1" "Glucocorticoid modulatory element-binding protein 2 OS=Homo sapiens OX=9606 GN=GMEB2 PE=1 SV=1" "0.000" "False" "15.407" "10" "4" "4" "4" "530" "56.4" "5.60" "10.76" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01342" "26205" "ENSG00000101216" "GMEB2" "E1P5J3; hsa:26205; Q5TDS0; Q9H431; Q9H4X7; Q9H4X8; Q9UF78; Q9UKD1; Q9ULF1" "" "" "0" "0" "0.972" "0.879" "0.877" "0.955" "0.856" "0.817" "0.941" "0.919" "0.986" "327.0" "317.9" "287.3" "286.7" "312.3" "279.9" "267.2" "307.7" "300.6" "322.5" "" "" "" "" "" "" "" "" "" "" "262.6" "229.4" "228.2" "192.1" "216.0" "210.0" "187.1" "224.7" "300.6" "262.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2746729675254705765" "False" "High" "IsMasterProtein" "Q6ZN18" "Zinc finger protein AEBP2 OS=Homo sapiens OX=9606 GN=AEBP2 PE=1 SV=2" "0.000" "False" "15.381" "8" "3" "3" "3" "517" "54.4" "5.21" "10.12" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "121536" "ENSG00000139154" "AEBP2" "hsa:121536; Q59FS5; Q6ZN18; Q6ZN62; Q96BG3" "PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "Histone modifications; Mesodermal commitment pathway; Interactome of polycomb repressive complex 2 (PRC2)" "5" "0" "1.070" "1.072" "1.103" "1.010" "1.065" "1.057" "1.114" "0.982" "1.091" "148.1" "158.5" "158.8" "163.4" "149.7" "157.7" "156.6" "165.0" "145.4" "161.5" "" "" "" "" "" "" "" "" "" "" "119.0" "114.3" "126.1" "109.5" "103.5" "118.3" "109.7" "120.5" "145.4" "131.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3037731205086659877" "False" "High" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "0.000" "False" "15.381" "17" "2" "5" "2" "159" "17.4" "9.67" "16.63" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "mRNA Splicing - Major Pathway" "" "1" "0" "0.930" "1.015" "0.913" "0.993" "0.923" "1.009" "0.955" "0.913" "0.962" "874.6" "813.3" "887.7" "799.0" "868.6" "807.4" "882.4" "835.7" "798.9" "841.2" "" "" "" "" "" "" "" "" "" "" "702.5" "586.9" "705.1" "535.3" "600.8" "605.8" "617.8" "610.3" "798.9" "684.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "967030651674579734" "False" "High" "IsMasterProtein" "Q9NV88" "Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2" "0.000" "False" "15.380" "10" "6" "6" "6" "658" "73.8" "6.33" "17.74" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10996, Pf16661, Pf21382" "55756" "ENSG00000104299" "INTS9" "B7Z560; B7Z6M5; hsa:55756; O00224; Q8TB16; Q9NV88" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "0.949" "1.010" "1.041" "1.091" "1.036" "1.103" "1.169" "1.127" "1.082" "638.3" "605.9" "644.9" "664.3" "696.7" "661.6" "704.2" "746.3" "719.1" "690.9" "" "" "" "" "" "" "" "" "" "" "512.7" "437.2" "512.3" "445.1" "481.8" "496.4" "493.0" "545.0" "719.1" "561.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973916192928746401" "False" "High" "IsMasterProtein" "Q8N6N7" "Acyl-CoA-binding domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ACBD7 PE=1 SV=1" "0.000" "False" "15.365" "26" "2" "3" "2" "88" "9.8" "6.71" "12.91" "2" "other metabolic processes" "" "other molecular function" "Pf00887" "414149" "ENSG00000176244" "ACBD7" "A6NCI2; B3KTG8; hsa:414149; Q8N6N7" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515623990102163669" "False" "High" "IsMasterProtein" "P51161" "Gastrotropin OS=Homo sapiens OX=9606 GN=FABP6 PE=1 SV=2" "0.000" "False" "15.362" "38" "4" "6" "4" "128" "14.4" "6.80" "16.16" "4" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf14651" "2172" "ENSG00000170231" "FABP6" "hsa:2172; P51161; Q07DR7; Q8TBI3; Q9UGI7" "Triglyceride catabolism; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "PPAR signaling pathway; Fatty acid transporters" "5" "0" "0.875" "1.075" "0.793" "0.867" "0.981" "0.764" "0.783" "0.986" "0.952" "88.5" "77.5" "95.2" "70.2" "76.8" "86.8" "67.6" "69.3" "87.3" "84.3" "" "" "" "" "" "" "" "" "" "" "71.1" "55.9" "75.6" "47.1" "53.1" "65.1" "47.4" "50.6" "87.3" "68.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2713677220638239159" "False" "High" "IsMasterProtein" "Q7L099" "Protein RUFY3 OS=Homo sapiens OX=9606 GN=RUFY3 PE=1 SV=1" "0.000" "False" "15.361" "7" "3" "3" "3" "469" "52.9" "5.49" "10.52" "3" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cell component" "" "Pf02759" "22902" "ENSG00000018189" "RUFY3" "B3KM25; B4DYW7; D9N163; hsa:22902; O94948; Q7L099; Q9UI00" "" "" "0" "0" "0.895" "0.967" "1.030" "1.115" "1.022" "0.812" "0.909" "1.033" "0.802" "63.1" "56.5" "61.0" "65.0" "70.4" "64.5" "51.2" "57.3" "65.2" "50.6" "" "" "" "" "" "" "" "" "" "" "50.7" "40.8" "48.5" "43.6" "48.7" "48.4" "35.9" "41.9" "65.2" "41.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2014146262064774288" "False" "High" "IsMasterProtein" "P09001" "Large ribosomal subunit protein uL3m OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "0.000" "False" "15.348" "16" "5" "6" "5" "348" "38.6" "9.48" "15.93" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.113" "1.123" "1.142" "1.040" "1.158" "1.035" "1.049" "1.084" "1.096" "306.1" "340.7" "343.9" "349.6" "318.3" "354.4" "316.8" "321.1" "331.9" "335.7" "" "" "" "" "" "" "" "" "" "" "245.9" "245.9" "273.1" "234.2" "220.2" "265.9" "221.8" "234.5" "331.9" "273.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1701299476432316153" "False" "High" "IsMasterProtein" "Q9BU61" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1" "0.000" "False" "15.242" "25" "4" "5" "4" "184" "20.3" "8.22" "13.04" "4" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf04430" "25915" "ENSG00000178057" "NDUFAF3" "hsa:25915; Q9BU61" "Complex I biogenesis" "" "1" "0" "0.987" "0.940" "1.021" "1.006" "0.850" "0.853" "1.001" "0.904" "0.911" "323.3" "319.2" "303.9" "330.1" "325.3" "274.8" "275.9" "323.7" "292.3" "294.4" "" "" "" "" "" "" "" "" "" "" "259.6" "230.3" "241.4" "221.2" "225.0" "206.2" "193.2" "236.4" "292.3" "239.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "456544607600152383" "False" "High" "IsMasterProtein" "Q9UJY5" "ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1" "0.000" "False" "15.238" "7" "6" "6" "6" "639" "70.3" "5.29" "18.53" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "26088" "ENSG00000100083" "GGA1" "A8K3D3; B0QYR7; hsa:26088; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; Q9UJY5" "TBC/RABGAPs; Amyloid fiber formation" "" "2" "0" "0.999" "0.934" "1.004" "0.943" "0.931" "0.863" "0.942" "0.987" "0.907" "559.0" "558.6" "522.3" "561.0" "526.9" "520.2" "482.4" "526.7" "551.6" "507.1" "" "" "" "" "" "" "" "" "" "" "449.0" "403.1" "414.9" "375.8" "364.4" "390.3" "337.8" "384.6" "551.6" "412.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493859873244139752" "False" "High" "IsMasterProtein" "Q86U86" "Protein polybromo-1 OS=Homo sapiens OX=9606 GN=PBRM1 PE=1 SV=1" "0.000" "False" "15.215" "3" "5" "5" "5" "1689" "192.8" "6.89" "14.89" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00505, Pf01426" "55193" "ENSG00000163939" "PBRM1" "A1L381; A1L382; A4FUJ7; hsa:55193; Q1RMD1; Q1RMD2; Q86U86; Q96MS2; Q9H2T3; Q9H2T4; Q9H2T5; Q9H301; Q9H314" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Clear cell renal cell carcinoma pathways" "3" "0" "1.103" "1.292" "1.199" "1.040" "1.073" "1.168" "1.238" "1.222" "1.214" "476.9" "526.2" "616.1" "571.6" "496.0" "511.8" "557.1" "590.3" "582.9" "578.9" "" "" "" "" "" "" "" "" "" "" "383.1" "379.7" "489.4" "383.0" "343.1" "384.0" "390.1" "431.1" "582.9" "470.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415250102849728185" "False" "High" "IsMasterProtein" "Q76FK4" "Nucleolar protein 8 OS=Homo sapiens OX=9606 GN=NOL8 PE=1 SV=1" "0.000" "False" "15.213" "4" "3" "3" "3" "1167" "131.5" "7.09" "8.92" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "55035" "ENSG00000198000; ENSG00000291347" "NOL8" "hsa:55035; Q5TCC7; Q5TCC8; Q5TCD3; Q5TCD5; Q5TCD6; Q5TCD7; Q76D35; Q76FK4; Q7L3E2; Q9H586; Q9H795; Q9H7W7; Q9H9J6; Q9NWA4; Q9NWM4" "" "" "0" "0" "1.186" "1.021" "1.248" "1.313" "1.169" "1.043" "1.353" "1.219" "1.110" "119.9" "142.2" "122.4" "149.7" "157.4" "140.1" "125.0" "162.1" "146.2" "133.1" "" "" "" "" "" "" "" "" "" "" "96.3" "102.6" "97.2" "100.3" "108.8" "105.1" "87.5" "118.4" "146.2" "108.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1403066018753267541" "False" "High" "IsMasterProtein" "Q96RU3" "Formin-binding protein 1 OS=Homo sapiens OX=9606 GN=FNBP1 PE=1 SV=2" "0.000" "False" "15.176" "6" "4" "4" "4" "617" "71.3" "5.72" "12.47" "4" "transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "23048" "ENSG00000187239" "FNBP1" "B7ZL12; E9PGQ4; hsa:23048; O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q96RU3; Q9H8H8; Q9NWD1" "Clathrin-mediated endocytosis; CDC42 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "" "5" "0" "0.817" "0.934" "0.743" "0.680" "0.921" "0.936" "0.746" "0.872" "0.905" "42.5" "34.7" "39.6" "31.6" "28.9" "39.1" "39.8" "31.7" "37.0" "38.4" "" "" "" "" "" "" "" "" "" "" "34.1" "25.0" "31.5" "21.2" "20.0" "29.4" "27.8" "23.1" "37.0" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7153575726197497326" "False" "High" "IsMasterProtein" "Q7Z6B0" "Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2" "0.000" "False" "15.175" "9" "4" "4" "4" "441" "49.9" "5.07" "13.19" "4" "transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "55297" "ENSG00000123106" "CCDC91" "B3KSA3; C9JR07; hsa:55297; Q68D43; Q6IA78; Q7Z6B0; Q8NEN7; Q9NUW9" "" "" "0" "0" "0.944" "0.954" "0.902" "1.033" "0.940" "1.018" "0.969" "1.007" "0.961" "467.4" "441.4" "446.1" "421.8" "482.9" "439.4" "475.9" "453.0" "470.6" "449.4" "" "" "" "" "" "" "" "" "" "" "375.4" "318.5" "354.4" "282.6" "334.0" "329.7" "333.2" "330.8" "470.6" "365.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985181273239411309" "False" "High" "IsMasterProtein" "Q5JUR7" "Testis-expressed protein 30 OS=Homo sapiens OX=9606 GN=TEX30 PE=1 SV=1" "0.000" "False" "15.172" "21" "5" "5" "5" "227" "25.6" "8.66" "10.72" "5" "" "" "" "Pf20408" "93081" "ENSG00000151287" "TEX30" "hsa:93081; Q5JUR7; Q5JUR8; Q96KZ8" "" "" "0" "0" "0.965" "0.941" "0.938" "0.912" "0.928" "1.010" "1.021" "0.937" "0.991" "307.1" "296.2" "288.9" "288.0" "279.9" "284.8" "310.3" "313.6" "287.8" "304.4" "" "" "" "" "" "" "" "" "" "" "246.6" "213.7" "229.5" "192.9" "193.6" "213.7" "217.3" "229.0" "287.8" "247.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "809495191273134722" "False" "High" "IsMasterProtein" "P42356" "Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4" "0.000" "False" "15.148" "2" "4" "4" "4" "2102" "236.7" "7.06" "11.07" "4" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf19274" "5297" "ENSG00000241973" "PI4KA" "hsa:5297; P42356; Q7Z625; Q9UPG2" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane" "Ectoderm differentiation; 22q11.2 copy number variation syndrome" "4" "0" "1.162" "1.124" "0.891" "1.218" "0.878" "0.791" "1.080" "1.254" "1.379" "29.4" "34.1" "33.0" "26.2" "35.8" "25.8" "23.2" "31.7" "36.8" "40.5" "" "" "" "" "" "" "" "" "" "" "23.6" "24.6" "26.2" "17.5" "24.7" "19.3" "16.3" "23.2" "36.8" "32.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7938684201688622214" "False" "High" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "0.000" "False" "15.147" "24" "5" "5" "5" "275" "29.7" "6.80" "13.86" "5" "transport" "other membranes;cytosol" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "" "3" "0" "0.921" "0.906" "0.925" "0.967" "0.877" "0.930" "0.920" "0.889" "0.924" "472.2" "434.9" "427.6" "436.8" "456.8" "414.2" "439.3" "434.6" "419.6" "436.6" "" "" "" "" "" "" "" "" "" "" "379.3" "313.8" "339.7" "292.7" "315.9" "310.8" "307.6" "317.4" "419.6" "355.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1854771477011875853" "False" "High" "IsMasterProtein" "Q14119" "Vascular endothelial zinc finger 1 OS=Homo sapiens OX=9606 GN=VEZF1 PE=1 SV=2" "0.000" "False" "15.147" "7" "4" "4" "2" "521" "56.9" "9.52" "12.19" "4" "stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "7716" "ENSG00000136451" "VEZF1" "hsa:7716; Q14119" "" "" "0" "0" "0.973" "1.054" "0.877" "0.851" "0.809" "0.803" "0.880" "0.818" "0.951" "41.1" "40.0" "43.3" "36.0" "35.0" "33.2" "33.0" "36.1" "33.6" "39.1" "" "" "" "" "" "" "" "" "" "" "33.0" "28.9" "34.4" "24.1" "24.2" "24.9" "23.1" "26.4" "33.6" "31.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339242402032558616" "False" "High" "IsMasterProtein" "P05091" "Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH2 PE=1 SV=2" "0.000" "False" "15.140" "5" "2" "3" "2" "517" "56.3" "7.05" "10.57" "2" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00171" "217" "ENSG00000111275" "ALDH2" "B4DW54; E7EUE5; hsa:217; P05091; Q03639; Q6IB13; Q6IV71" "Mitochondrial protein degradation; Smooth Muscle Contraction; Ethanol oxidation; Metabolism of serotonin" "Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity" "8" "0" "0.889" "0.875" "1.215" "1.080" "1.062" "1.066" "0.947" "0.983" "1.103" "44.1" "39.2" "38.6" "53.6" "47.6" "46.9" "47.1" "41.8" "43.4" "48.7" "" "" "" "" "" "" "" "" "" "" "35.4" "28.3" "30.7" "35.9" "33.0" "35.2" "32.9" "30.5" "43.4" "39.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1732426368668540463" "False" "High" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "0.000" "False" "15.126" "20" "2" "2" "2" "165" "19.0" "5.21" "8.10" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "1.018" "1.005" "1.017" "1.179" "1.057" "1.369" "1.385" "1.054" "1.038" "75.2" "76.6" "75.5" "76.5" "88.7" "79.5" "103.0" "104.2" "79.3" "78.1" "" "" "" "" "" "" "" "" "" "" "60.4" "55.3" "60.0" "51.2" "61.3" "59.6" "72.1" "76.1" "79.3" "63.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3146849743976844279" "False" "High" "IsMasterProtein" "Q02809" "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2" "0.000" "False" "15.123" "6" "4" "5" "3" "727" "83.5" "6.95" "16.51" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03171" "5351" "ENSG00000083444" "PLOD1" "B4DR87; hsa:5351; Q02809; Q96AV9; Q9H132" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "1.053" "1.063" "0.858" "0.985" "1.044" "1.073" "1.027" "1.042" "0.883" "71.4" "75.2" "75.9" "61.3" "70.4" "74.6" "76.6" "73.3" "74.5" "63.1" "" "" "" "" "" "" "" "" "" "" "57.4" "54.3" "60.3" "41.0" "48.7" "56.0" "53.7" "53.6" "74.5" "51.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6002739480164065296" "False" "High" "IsMasterProtein" "Q14137" "Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2" "0.000" "False" "15.117" "5" "3" "3" "3" "746" "83.6" "6.19" "10.86" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08145" "23246" "ENSG00000261236" "BOP1" "hsa:23246; Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.046" "0.835" "0.813" "1.085" "1.136" "0.996" "1.184" "0.963" "0.899" "22.7" "23.7" "18.9" "18.4" "24.6" "25.8" "22.6" "26.8" "21.8" "20.4" "" "" "" "" "" "" "" "" "" "" "18.2" "17.1" "15.0" "12.3" "17.0" "19.3" "15.8" "19.6" "21.8" "16.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6713486079386730204" "False" "High" "IsMasterProtein" "P50454" "Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2" "0.000" "False" "15.117" "8" "3" "4" "3" "418" "46.4" "8.69" "14.29" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "non-structural extracellular;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "871" "ENSG00000149257" "SERPINH1" "B3KVJ3; hsa:871; P29043; P50454; Q5XPB4; Q6NSJ6; Q8IY96; Q9NP88" "Collagen biosynthesis and modifying enzymes" "Endochondral ossification; Type I collagen synthesis in the context of osteogenesis imperfecta; Endochondral ossification with skeletal dysplasias; 15q13.3 copy number variation syndrome; 15q11q13 copy number variation" "6" "0" "1.212" "1.237" "1.054" "1.067" "1.159" "0.861" "1.128" "1.239" "1.141" "100.7" "122.0" "124.6" "106.1" "107.4" "116.7" "86.7" "113.6" "124.8" "114.9" "" "" "" "" "" "" "" "" "" "" "80.9" "88.0" "98.9" "71.1" "74.3" "87.5" "60.7" "83.0" "124.8" "93.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7755566090060093643" "False" "High" "IsMasterProtein" "P35914" "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2" "0.000" "False" "15.110" "12" "4" "4" "4" "325" "34.3" "8.54" "14.36" "4" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00682" "3155" "ENSG00000117305" "HMGCL" "B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8" "Peroxisomal protein import; Synthesis of Ketone Bodies" "Amino acid metabolism" "3" "0" "1.023" "1.075" "0.955" "1.092" "1.097" "1.051" "1.067" "1.113" "1.100" "378.7" "387.6" "407.2" "361.6" "413.5" "415.3" "398.0" "404.1" "421.6" "416.7" "" "" "" "" "" "" "" "" "" "" "304.2" "279.7" "323.5" "242.3" "286.0" "311.6" "278.7" "295.1" "421.6" "338.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1899154642705730358" "False" "High" "IsMasterProtein" "Q9UNK0" "Syntaxin-8 OS=Homo sapiens OX=9606 GN=STX8 PE=1 SV=2" "0.000" "False" "15.092" "21" "4" "4" "4" "236" "26.9" "4.98" "13.94" "4" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739" "9482" "ENSG00000170310" "STX8" "hsa:9482; O60712; Q53XT8; Q9UNK0" "" "" "0" "0" "0.833" "0.743" "1.118" "0.863" "0.855" "0.914" "0.870" "0.814" "0.908" "134.2" "111.8" "99.8" "150.1" "115.8" "114.7" "122.7" "116.7" "109.2" "121.9" "" "" "" "" "" "" "" "" "" "" "107.8" "80.7" "79.3" "100.6" "80.1" "86.1" "85.9" "85.3" "109.2" "99.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3307427478696066462" "False" "High" "IsMasterProtein" "Q96AJ9" "Vesicle transport through interaction with t-SNAREs homolog 1A OS=Homo sapiens OX=9606 GN=VTI1A PE=1 SV=2" "0.000" "False" "15.086" "20" "4" "5" "4" "217" "25.2" "6.40" "14.59" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "143187" "ENSG00000151532" "VTI1A" "A2A307; B4E137; hsa:143187; Q5W0D7; Q96AJ9" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "2" "0" "0.900" "0.773" "1.009" "0.990" "0.900" "0.989" "0.868" "0.889" "0.945" "182.8" "164.5" "141.3" "184.5" "181.1" "164.5" "180.8" "158.7" "162.6" "172.8" "" "" "" "" "" "" "" "" "" "" "146.8" "118.7" "112.2" "123.6" "125.2" "123.4" "126.6" "115.9" "162.6" "140.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278874134147621934" "False" "High" "IsMasterProtein" "P51451" "Tyrosine-protein kinase Blk OS=Homo sapiens OX=9606 GN=BLK PE=1 SV=3" "0.000" "False" "15.083" "10" "6" "9" "5" "505" "57.7" "7.87" "22.98" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "640" "ENSG00000136573; ENSG00000285369" "BLK" "hsa:640; P51451; Q16291; Q96IN1" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RUNX1 regulates transcription of genes involved in BCR signaling" "B cell receptor signaling pathway; Focal adhesion; Genes associated with the development of rheumatoid arthritis; 8p23.1 copy number variation syndrome" "6" "0" "1.057" "0.980" "1.052" "1.123" "1.058" "1.044" "1.033" "1.018" "1.022" "751.1" "793.9" "735.8" "790.0" "843.6" "794.4" "783.9" "776.1" "764.8" "767.6" "" "" "" "" "" "" "" "" "" "" "603.3" "572.8" "584.5" "529.3" "583.4" "596.0" "548.8" "566.8" "764.8" "624.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5142432278754861003" "False" "High" "IsMasterProtein" "Q5TEC6" "Histone H3-7 OS=Homo sapiens OX=9606 GN=H3-7 PE=1 SV=1" "0.000" "False" "15.070" "26" "4" "17" "2" "136" "15.4" "11.27" "57.86" "4" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "" "ENSG00000273213" "H3-7" "Q5TEC6" "" "" "0" "0" "1.090" "1.085" "1.262" "1.019" "1.127" "0.884" "0.922" "0.980" "1.015" "266.7" "290.6" "289.2" "336.5" "271.7" "300.5" "235.7" "245.7" "261.4" "270.8" "" "" "" "" "" "" "" "" "" "" "214.2" "209.7" "229.7" "225.5" "187.9" "225.5" "165.0" "179.5" "261.4" "220.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5840239989080540215" "False" "High" "IsMasterProtein" "Q8IVH2" "Forkhead box protein P4 OS=Homo sapiens OX=9606 GN=FOXP4 PE=1 SV=1" "0.000" "False" "15.061" "5" "3" "3" "3" "680" "73.4" "6.40" "10.24" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16159" "116113" "ENSG00000137166" "FOXP4" "hsa:116113; Q5W098; Q7Z7F8; Q8IVH2; Q8IW55; Q96E19" "" "" "0" "0" "0.955" "0.967" "0.969" "0.959" "0.941" "0.981" "0.910" "1.032" "0.895" "158.1" "151.1" "152.8" "153.3" "151.6" "148.8" "155.1" "143.9" "163.2" "141.5" "" "" "" "" "" "" "" "" "" "" "127.0" "109.0" "121.4" "102.7" "104.9" "111.6" "108.6" "105.1" "163.2" "115.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8333462526308289964" "False" "High" "IsMasterProtein" "O60671" "Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1" "0.000" "False" "15.047" "14" "4" "5" "4" "282" "31.8" "4.83" "15.09" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02144" "5810" "ENSG00000113456" "RAD1" "hsa:5810; O60671; O75572; O95304; Q1W161; Q5KSM0; Q5KSM1; Q9UEP1" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "10" "0" "0.881" "1.016" "1.061" "1.057" "0.869" "1.092" "1.032" "1.032" "1.018" "155.8" "137.2" "158.3" "165.3" "164.6" "135.4" "170.0" "160.7" "160.8" "158.5" "" "" "" "" "" "" "" "" "" "" "125.1" "99.0" "125.7" "110.8" "113.8" "101.6" "119.1" "117.4" "160.8" "128.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2503112779916804665" "False" "High" "IsMasterProtein" "Q8WV28" "B-cell linker protein OS=Homo sapiens OX=9606 GN=BLNK PE=1 SV=2" "0.000" "False" "15.018" "11" "7" "7" "7" "456" "50.4" "8.16" "19.76" "7" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017" "29760" "ENSG00000095585" "BLNK" "hsa:29760; O75498; O75499; Q2MD49; Q8WV28" "Regulation of signaling by CBL; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "5" "0" "0.991" "0.987" "1.049" "0.931" "1.012" "0.919" "0.968" "0.927" "0.991" "304.6" "301.7" "300.6" "319.5" "283.6" "308.4" "280.1" "295.0" "282.4" "301.8" "" "" "" "" "" "" "" "" "" "" "244.6" "217.7" "238.8" "214.1" "196.1" "231.4" "196.1" "215.4" "282.4" "245.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3683679323439236664" "False" "High" "IsMasterProtein" "Q6IPR3" "tRNA wybutosine-synthesizing protein 3 homolog OS=Homo sapiens OX=9606 GN=TYW3 PE=1 SV=2" "0.000" "False" "15.018" "14" "3" "4" "3" "259" "29.8" "7.68" "12.45" "3" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02676" "127253" "ENSG00000162623" "TYW3" "B4DSP9; E9PGR7; hsa:127253; Q5HYJ0; Q6IPR3; Q8N7L1" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "1.029" "1.103" "1.056" "1.032" "1.138" "0.908" "1.017" "1.002" "1.103" "335.9" "345.6" "370.4" "354.6" "346.5" "382.2" "304.9" "341.6" "336.7" "370.6" "" "" "" "" "" "" "" "" "" "" "269.8" "249.4" "294.3" "237.6" "239.7" "286.7" "213.5" "249.4" "336.7" "301.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4746600301426645057" "False" "High" "IsMasterProtein" "Q9BW62" "Katanin p60 ATPase-containing subunit A-like 1 OS=Homo sapiens OX=9606 GN=KATNAL1 PE=1 SV=1" "0.000" "False" "15.008" "8" "3" "3" "2" "490" "55.4" "6.74" "9.10" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "84056" "ENSG00000102781" "KATNAL1" "A8K5X4; hsa:84056; Q9BW62" "" "" "0" "1" "0.987" "0.973" "1.040" "1.075" "1.063" "1.028" "1.090" "1.055" "1.071" "204.8" "202.2" "199.2" "213.1" "220.2" "217.8" "210.7" "223.4" "216.2" "219.3" "" "" "" "" "" "" "" "" "" "" "164.5" "145.9" "158.3" "142.8" "152.3" "163.4" "147.5" "163.1" "216.2" "178.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339372435308816495" "False" "High" "IsMasterProtein" "Q8IWT0" "Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2" "0.000" "False" "15.007" "13" "2" "3" "2" "167" "19.5" "4.49" "12.29" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01951" "339487" "ENSG00000176261" "ZBTB8OS" "hsa:339487; Q5TGK5; Q6PDA1; Q8IWS9; Q8IWT0; Q8NEV6; Q8NEV7" "tRNA processing in the nucleus" "" "1" "0" "0.957" "1.072" "0.792" "0.755" "0.877" "0.761" "0.839" "0.855" "0.923" "513.6" "491.5" "550.4" "406.7" "387.5" "450.3" "390.8" "430.8" "439.2" "473.9" "" "" "" "" "" "" "" "" "" "" "412.5" "354.6" "437.2" "272.5" "268.0" "337.8" "273.6" "314.6" "439.2" "385.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8568450672967987050" "False" "High" "IsMasterProtein" "Q9NWX5" "Ankyrin repeat and SOCS box protein 6 OS=Homo sapiens OX=9606 GN=ASB6 PE=1 SV=1" "0.000" "False" "14.995" "10" "3" "3" "3" "421" "47.1" "6.01" "12.30" "3" "protein metabolism;other metabolic processes;signal transduction" "cytosol" "" "Pf07525, Pf12796, Pf13637" "140459" "ENSG00000148331" "ASB6" "hsa:140459; Q5SZB7; Q9BV15; Q9NWX5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.051" "1.052" "1.244" "1.067" "0.949" "1.171" "1.121" "1.023" "1.081" "298.5" "313.6" "314.1" "371.3" "318.6" "283.2" "349.6" "334.5" "305.3" "322.7" "" "" "" "" "" "" "" "" "" "" "239.7" "226.3" "249.5" "248.8" "220.3" "212.5" "244.7" "244.3" "305.3" "262.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "504093738677667823" "False" "High" "IsMasterProtein" "O14867" "Transcription regulator protein BACH1 OS=Homo sapiens OX=9606 GN=BACH1 PE=1 SV=2" "0.000" "False" "14.991" "6" "3" "3" "3" "736" "81.9" "5.05" "9.52" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "571" "ENSG00000156273" "BACH1" "hsa:571; O14867; O43285; Q6ICU0" "Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes" "Integrated cancer pathway; Ferroptosis" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5598137855594202811" "False" "High" "IsMasterProtein" "Q9Y6G3" "Large ribosomal subunit protein mL42 OS=Homo sapiens OX=9606 GN=MRPL42 PE=1 SV=1" "0.000" "False" "14.988" "27" "2" "4" "2" "142" "16.7" "8.35" "12.93" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10210" "28977" "ENSG00000198015" "MRPL42" "hsa:28977; Q6FID1; Q96Q48; Q9P0S1; Q9Y6G3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.124" "1.099" "0.907" "1.172" "0.881" "0.902" "0.726" "0.871" "0.677" "30.3" "34.1" "33.3" "27.5" "35.5" "26.7" "27.3" "22.0" "26.4" "20.5" "" "" "" "" "" "" "" "" "" "" "24.3" "24.6" "26.4" "18.4" "24.6" "20.0" "19.1" "16.1" "26.4" "16.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6147929922391527183" "False" "High" "IsMasterProtein" "P49116" "Nuclear receptor subfamily 2 group C member 2 OS=Homo sapiens OX=9606 GN=NR2C2 PE=1 SV=1" "0.000" "False" "14.985" "6" "3" "3" "3" "596" "65.4" "6.28" "12.98" "3" "developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7182" "ENSG00000177463" "NR2C2" "A8K3H5; B6ZGT8; hsa:7182; P49116; P55092" "Nuclear Receptor transcription pathway" "Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer" "5" "0" "1.101" "1.058" "1.044" "1.055" "1.107" "0.976" "1.029" "1.109" "1.055" "340.2" "374.6" "359.8" "355.2" "359.0" "376.6" "332.0" "350.1" "377.3" "359.0" "" "" "" "" "" "" "" "" "" "" "273.2" "270.3" "285.8" "238.0" "248.3" "282.6" "232.5" "255.7" "377.3" "291.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514790625548438605" "False" "High" "IsMasterProtein" "Q8WUX2" "Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1" "0.000" "False" "14.980" "17" "3" "5" "3" "184" "20.9" "5.43" "17.77" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf04752" "494143" "ENSG00000143942" "CHAC2" "hsa:494143; Q8WUX2; Q8WVI8" "Glutathione synthesis and recycling" "" "1" "0" "1.040" "1.077" "0.997" "1.058" "1.093" "0.998" "1.045" "1.143" "1.003" "689.3" "716.8" "742.5" "687.3" "729.3" "753.6" "688.0" "720.6" "787.5" "691.5" "" "" "" "" "" "" "" "" "" "" "553.6" "517.2" "589.8" "460.5" "504.4" "565.4" "481.7" "526.3" "787.5" "562.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720179589779934486" "False" "High" "IsMasterProtein" "O96007" "Molybdopterin synthase catalytic subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1" "0.000" "False" "14.976" "14" "2" "3" "2" "188" "20.9" "5.44" "12.33" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02391" "4338" "ENSG00000164172" "MOCS2" "hsa:4338; O96007; Q6IAI3" "Molybdenum cofactor biosynthesis" "Metabolic Epileptic Disorders" "2" "0" "1.065" "0.829" "1.047" "1.111" "0.798" "1.045" "0.948" "0.895" "0.871" "60.2" "64.1" "49.9" "63.0" "66.9" "48.0" "62.9" "57.1" "53.9" "52.4" "" "" "" "" "" "" "" "" "" "" "48.4" "46.3" "39.6" "42.2" "46.3" "36.0" "44.0" "41.7" "53.9" "42.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594177095458516104" "False" "High" "IsMasterProtein" "P24386" "Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens OX=9606 GN=CHM PE=1 SV=3" "0.000" "False" "14.969" "7" "5" "7" "5" "653" "73.4" "4.75" "19.42" "5" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1121" "ENSG00000188419" "CHM" "A1L4D2; hsa:1121; O43732; P24386" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "" "3" "0" "1.022" "0.986" "0.967" "1.020" "1.000" "0.948" "0.996" "1.003" "1.082" "731.2" "747.5" "721.1" "706.7" "745.9" "731.0" "692.9" "728.5" "733.3" "791.3" "" "" "" "" "" "" "" "" "" "" "587.3" "539.4" "572.8" "473.5" "515.9" "548.4" "485.1" "532.0" "733.3" "643.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7436482478148807515" "False" "High" "IsMasterProtein" "Q86TB9" "Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2" "0.000" "False" "14.955" "5" "5" "6" "5" "770" "86.8" "6.67" "19.54" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf09770" "219988" "ENSG00000166889" "PATL1" "B3KXT9; hsa:219988; Q2TA86; Q6P166; Q86TB9; Q8N9M6; Q8NI63" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "0.965" "0.906" "1.000" "0.899" "0.920" "0.919" "1.049" "0.942" "0.886" "118.5" "114.4" "107.4" "118.5" "106.6" "109.1" "108.9" "124.3" "111.7" "105.1" "" "" "" "" "" "" "" "" "" "" "95.2" "82.5" "85.3" "79.4" "73.7" "81.8" "76.2" "90.8" "111.7" "85.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117675378851989584" "False" "High" "IsMasterProtein" "P56270" "Myc-associated zinc finger protein OS=Homo sapiens OX=9606 GN=MAZ PE=1 SV=1" "0.000" "False" "14.952" "10" "5" "5" "3" "477" "48.6" "8.95" "15.16" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "4150" "ENSG00000103495" "MAZ" "A8QJL9; C6G496; G5E927; H3BQD6; hsa:4150; P56270; Q15703; Q8NFN7; Q99443" "" "16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "0" "0.918" "0.984" "0.900" "1.147" "1.004" "1.321" "1.174" "0.941" "1.090" "222.1" "203.8" "218.5" "199.8" "254.6" "222.9" "293.4" "260.7" "208.9" "242.1" "" "" "" "" "" "" "" "" "" "" "178.4" "147.1" "173.6" "133.9" "176.1" "167.2" "205.4" "190.4" "208.9" "196.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4923515790283792107" "False" "High" "IsMasterProtein" "Q7Z309" "PABIR family member 2 OS=Homo sapiens OX=9606 GN=PABIR2 PE=1 SV=2" "0.000" "False" "14.949" "18" "4" "5" "4" "247" "26.9" "6.37" "12.74" "4" "" "" "enzyme regulator activity" "" "159090" "ENSG00000156504" "PABIR2" "A8K902; hsa:159090; Q6PIM2; Q6ZU47; Q6ZV64; Q6ZVE4; Q7Z309; Q8TB75" "" "" "0" "0" "0.954" "0.895" "0.881" "0.935" "0.858" "0.879" "0.934" "0.867" "0.932" "398.4" "380.2" "356.7" "350.8" "372.6" "341.8" "350.2" "372.0" "345.6" "371.1" "" "" "" "" "" "" "" "" "" "" "320.0" "274.3" "283.3" "235.0" "257.7" "256.4" "245.2" "271.6" "345.6" "301.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1789067979643489698" "False" "High" "IsMasterProtein" "P46976" "Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4" "0.000" "False" "14.944" "9" "3" "5" "3" "350" "39.4" "5.53" "17.00" "3" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01501" "2992" "ENSG00000163754" "GYG1" "D3DNH0; D3DNH1; D3DNH2; hsa:2992; P46976; Q6FHZ1; Q9UNV0" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Myoclonic epilepsy of Lafora; Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism" "10" "0" "1.123" "1.037" "1.190" "1.256" "1.122" "1.369" "1.211" "1.240" "1.282" "186.4" "209.3" "193.2" "221.9" "234.1" "209.1" "255.1" "225.8" "231.2" "238.9" "" "" "" "" "" "" "" "" "" "" "149.7" "151.0" "153.5" "148.7" "161.9" "156.9" "178.6" "164.9" "231.2" "194.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-708383096801431027" "False" "High" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "0.000" "False" "14.915" "21" "2" "4" "2" "91" "10.8" "10.73" "13.48" "2" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "2" "0" "0.886" "0.965" "0.890" "0.840" "0.895" "0.828" "0.938" "0.849" "0.943" "607.2" "537.9" "585.7" "540.6" "510.3" "543.7" "502.8" "569.8" "515.5" "572.7" "" "" "" "" "" "" "" "" "" "" "487.7" "388.1" "465.3" "362.2" "352.9" "407.9" "352.1" "416.1" "515.5" "465.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841941710175491915" "False" "High" "IsMasterProtein" "Q5HYK3" "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ5 PE=1 SV=2" "0.000" "False" "14.905" "9" "3" "3" "3" "327" "37.1" "6.95" "11.79" "3" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01209" "84274" "ENSG00000110871" "COQ5" "B2RDU9; B3GK62; B4DEJ4; hsa:84274; Q32Q28; Q53HH0; Q5HYK3; Q96LV1; Q9BSP8" "Ubiquinol biosynthesis" "" "1" "0" "0.876" "0.817" "0.943" "0.938" "0.932" "0.830" "0.854" "0.848" "0.963" "202.3" "177.1" "165.2" "190.7" "189.8" "188.6" "167.9" "172.8" "171.7" "194.7" "" "" "" "" "" "" "" "" "" "" "162.5" "127.8" "131.2" "127.8" "131.3" "141.5" "117.5" "126.2" "171.7" "158.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901447341290801043" "False" "High" "IsMasterProtein" "Q66PJ3" "ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=3" "0.000" "False" "14.889" "15" "3" "3" "3" "237" "26.4" "10.86" "9.50" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10500" "51329" "ENSG00000182196" "ARL6IP4" "A4UCR8; B3V0L0; B3V0L1; hsa:51329; Q4F966; Q504R8; Q66PJ3; Q96BI2; Q9NR05; Q9P2R9" "" "" "0" "0" "1.096" "1.187" "1.247" "1.167" "1.188" "1.294" "1.409" "1.214" "1.049" "59.3" "65.0" "70.4" "73.9" "69.2" "70.4" "76.7" "83.5" "72.0" "62.2" "" "" "" "" "" "" "" "" "" "" "47.6" "46.9" "55.9" "49.5" "47.8" "52.8" "53.7" "61.0" "72.0" "50.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6395227692188504005" "False" "High" "IsMasterProtein" "Q7Z3K3" "Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2" "0.000" "False" "14.872" "2" "2" "2" "2" "1410" "155.2" "7.40" "7.50" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03184, Pf03221" "23126" "ENSG00000143442" "POGZ" "B4DTP8; B4DYL9; B7ZBY5; E9PM80; hsa:23126; O75049; Q3LIC4; Q5SZS1; Q5SZS2; Q5SZS3; Q5SZS4; Q7Z3K3; Q8TDZ7; Q9Y4X7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7469427958651967746" "False" "High" "IsMasterProtein" "Q9GZL7" "Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2" "0.000" "False" "14.871" "9" "4" "4" "4" "423" "47.7" "5.90" "13.57" "4" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08154" "55759" "ENSG00000138442" "WDR12" "B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.862" "0.933" "0.928" "0.888" "1.011" "0.988" "0.887" "0.983" "0.938" "512.1" "441.5" "478.0" "475.1" "454.7" "517.9" "505.8" "454.5" "503.3" "480.5" "" "" "" "" "" "" "" "" "" "" "411.3" "318.6" "379.7" "318.3" "314.5" "388.6" "354.1" "331.9" "503.3" "390.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5260823146616738925" "False" "High" "IsMasterProtein" "O43829" "Zinc finger and BTB domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZBTB14 PE=1 SV=2" "0.000" "False" "14.863" "9" "4" "4" "4" "449" "50.9" "6.04" "10.97" "4" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "7541" "ENSG00000198081" "ZBTB14" "hsa:7541; O00403; O43829; Q2TB80" "" "" "0" "0" "1.203" "0.980" "1.131" "1.080" "1.014" "1.029" "0.934" "0.958" "1.131" "244.9" "294.7" "240.1" "277.0" "264.6" "248.4" "252.0" "228.7" "234.7" "277.1" "" "" "" "" "" "" "" "" "" "" "196.7" "212.7" "190.8" "185.6" "183.0" "186.4" "176.5" "167.0" "234.7" "225.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340038753290804182" "False" "High" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "0.000" "False" "14.862" "3" "3" "4" "3" "1047" "119.8" "5.66" "12.67" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826, Pf21091" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2129800861400375686" "False" "High" "IsMasterProtein" "O60220" "Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1" "0.000" "False" "14.839" "34" "3" "4" "3" "97" "11.0" "5.16" "10.51" "3" "cell organization and biogenesis;transport;developmental processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "1678" "ENSG00000126953" "TIMM8A" "B2R5A6; O60220; Q6IRW6" "Mitochondrial protein import" "" "1" "0" "1.121" "0.954" "1.114" "1.060" "1.019" "1.138" "0.970" "0.968" "1.030" "491.7" "551.1" "469.0" "547.6" "521.1" "501.1" "559.7" "476.8" "476.1" "506.5" "" "" "" "" "" "" "" "" "" "" "394.9" "397.7" "372.5" "366.9" "360.4" "376.0" "391.9" "348.2" "476.1" "411.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1788576308263676540" "False" "High" "IsMasterProtein" "Q9BUK6" "Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1" "0.000" "False" "14.831" "5" "3" "3" "3" "570" "61.8" "6.11" "11.92" "3" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion;other cell component" "" "Pf10644, Pf14881" "55154" "ENSG00000125459" "MSTO1" "hsa:55154; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9BUK6; Q9NQX2; Q9NVU4" "" "" "0" "0" "1.022" "0.947" "1.016" "1.022" "1.011" "0.976" "0.947" "1.025" "0.964" "507.8" "518.9" "481.0" "516.1" "518.9" "513.3" "495.6" "481.0" "520.3" "489.7" "" "" "" "" "" "" "" "" "" "" "407.9" "374.5" "382.1" "345.8" "358.9" "385.1" "347.0" "351.3" "520.3" "398.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4045891090085866349" "False" "High" "IsMasterProtein" "Q6N063" "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=OGFOD2 PE=1 SV=2" "0.000" "False" "14.828" "10" "3" "4" "3" "350" "39.0" "5.68" "13.03" "3" "" "" "other molecular function" "" "79676" "ENSG00000111325" "OGFOD2" "B3KT24; hsa:79676; Q4KN13; Q6N023; Q6N063; Q9H8K6" "" "" "0" "0" "1.003" "0.975" "1.081" "1.105" "1.029" "1.030" "1.005" "0.994" "1.059" "143.4" "143.8" "139.9" "155.0" "158.4" "147.5" "147.7" "144.2" "142.6" "151.8" "" "" "" "" "" "" "" "" "" "" "115.2" "103.8" "111.1" "103.9" "109.6" "110.7" "103.4" "105.3" "142.6" "123.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6511219665607626480" "False" "High" "IsMasterProtein" "Q9NZM4" "BRD4-interacting chromatin-remodeling complex-associated protein OS=Homo sapiens OX=9606 GN=BICRA PE=1 SV=2" "0.000" "False" "14.824" "2" "2" "2" "2" "1560" "158.4" "6.65" "8.88" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15249" "29998" "ENSG00000063169" "BICRA" "A8MW01; hsa:29998; Q9NZM4" "" "" "0" "0" "1.143" "1.154" "0.949" "1.113" "1.157" "1.056" "1.036" "1.095" "1.167" "126.7" "144.8" "146.2" "120.3" "141.1" "146.6" "133.9" "131.3" "138.8" "147.9" "" "" "" "" "" "" "" "" "" "" "101.8" "104.5" "116.1" "80.6" "97.6" "110.0" "93.7" "95.9" "138.8" "120.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1949176893953303809" "False" "High" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "0.000" "False" "14.798" "23" "3" "5" "3" "219" "24.6" "4.83" "14.48" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "Ferroptosis" "3" "0" "0.973" "1.015" "1.073" "1.030" "0.909" "1.050" "1.058" "1.001" "0.980" "329.9" "321.2" "334.8" "353.9" "340.0" "300.0" "346.6" "349.1" "330.3" "323.5" "" "" "" "" "" "" "" "" "" "" "265.0" "231.7" "265.9" "237.1" "235.1" "225.1" "242.7" "255.0" "330.3" "263.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043086942307680796" "False" "High" "IsMasterProtein" "P63220" "Small ribosomal subunit protein eS21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "0.000" "False" "14.773" "40" "3" "7" "3" "83" "9.1" "8.50" "25.24" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.018" "1.149" "1.161" "1.292" "1.176" "1.291" "1.177" "1.124" "1.147" "879.6" "895.5" "1010.5" "1021.1" "1136.7" "1034.6" "1135.4" "1035.7" "988.8" "1009.2" "" "" "" "" "" "" "" "" "" "" "706.5" "646.2" "802.7" "684.1" "786.2" "776.3" "794.9" "756.4" "988.8" "820.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2600718552513118007" "False" "High" "IsMasterProtein" "Q86VR2" "Reticulophagy regulator 3 OS=Homo sapiens OX=9606 GN=RETREG3 PE=1 SV=1" "0.000" "False" "14.772" "10" "4" "4" "4" "466" "51.4" "4.97" "13.98" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "" "162427" "ENSG00000141699" "RETREG3" "B3KR75; hsa:162427; Q86VR2" "" "" "0" "0" "0.994" "0.929" "0.995" "0.956" "0.950" "0.915" "0.896" "0.933" "0.919" "305.2" "303.2" "283.4" "303.6" "291.8" "289.8" "279.2" "273.4" "284.7" "280.6" "" "" "" "" "" "" "" "" "" "" "245.1" "218.8" "225.1" "203.4" "201.8" "217.4" "195.5" "199.6" "284.7" "228.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5195963912300285736" "False" "High" "IsMasterProtein" "O43896" "Kinesin-like protein KIF1C OS=Homo sapiens OX=9606 GN=KIF1C PE=1 SV=3" "0.000" "False" "14.763" "5" "4" "4" "4" "1103" "122.9" "6.90" "10.34" "4" "transport;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf16183" "10749" "ENSG00000129250" "KIF1C" "D3DTL6; hsa:10749; O43896; O75186; Q5U618" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "7q11.23 distal copy number variation" "3" "0" "0.980" "0.965" "0.935" "1.189" "1.060" "1.171" "1.089" "1.089" "0.998" "58.4" "57.3" "56.4" "54.6" "69.4" "61.9" "68.4" "63.6" "63.6" "58.3" "" "" "" "" "" "" "" "" "" "" "46.9" "41.3" "44.8" "36.6" "48.0" "46.5" "47.9" "46.4" "63.6" "47.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9085991407022296267" "False" "High" "IsMasterProtein" "P01920" "HLA class II histocompatibility antigen, DQ beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DQB1 PE=1 SV=2" "0.000" "False" "14.758" "11" "4" "4" "3" "261" "30.0" "7.25" "12.55" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3119" "ENSG00000225824; ENSG00000231286; ENSG00000233209" "HLA-DQB1" "A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0; B0S7Y7; B1A0K6; B1GXI3; B3VLT3; B5BLN7; B7VU69; C0MQ34; C0MQ35; C8ZL52; C8ZLJ8; C8ZLJ9; C9DRQ3; hsa:3119; O19708; O19713; O19724; O62861; O78046; O78221; O78223; O98034; O98201; P01917; P01918; P01919; P01920; P03992; P05537; P79482; P79526; P79544; P79551; Q08GC8; Q09035; Q0E4V9; Q1M312; Q29731; Q29877; Q29884; Q29915; Q29966; Q2P9N3; Q2QK85; Q30061; Q30075; Q30076; Q30080; Q30081; Q30082; Q30083; Q30084; Q30089; Q30095; Q31633; Q38I47; Q45UE3; Q4QZB5; Q53I44; Q564J6; Q5G841; Q5ISH1; Q5ISH3; Q5W1E1; Q5Y7G8; Q643R4; Q6B9X1; Q70VH8; Q7YP69; Q8HWH0; Q8MH58; Q8SNB4; Q8SND1; Q8SP70; Q8WMA3; Q9BD17; Q9MYH2; Q9TPA9; Q9XRY6; Q9XRY7; Q9XRZ2" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777043105444546084" "False" "High" "IsMasterProtein" "P00387" "NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3" "0.000" "False" "14.757" "14" "4" "4" "4" "301" "34.2" "7.59" "12.43" "4" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00175, Pf00970" "1727" "ENSG00000100243" "CYB5R3" "B1AHF2; B7Z7L3; hsa:1727; O75675; P00387; Q8TDL8; Q8WTS8; Q9UEN4; Q9UEN5; Q9UL55; Q9UL56" "Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism" "Oxidation by cytochrome P450" "4" "0" "1.004" "0.980" "1.075" "1.032" "1.099" "0.942" "0.914" "0.826" "0.949" "153.4" "154.0" "150.4" "164.9" "158.3" "168.6" "144.5" "140.2" "126.7" "145.6" "" "" "" "" "" "" "" "" "" "" "123.2" "111.1" "119.4" "110.5" "109.5" "126.5" "101.2" "102.4" "126.7" "118.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3537193466780696360" "False" "High" "IsMasterProtein" "P30047" "GTP cyclohydrolase 1 feedback regulatory protein OS=Homo sapiens OX=9606 GN=GCHFR PE=1 SV=3" "0.000" "False" "14.752" "29" "2" "3" "2" "84" "9.7" "6.54" "8.66" "2" "other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf06399" "2644" "ENSG00000137880" "GCHFR" "B2R4L6; B7ZLM8; hsa:2644; P30047; Q2M1Q2; Q99749" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664937440056635092" "False" "High" "IsMasterProtein" "Q9BQ48" "Large ribosomal subunit protein bL34m OS=Homo sapiens OX=9606 GN=MRPL34 PE=1 SV=1" "0.000" "False" "14.741" "24" "2" "3" "2" "92" "10.2" "12.25" "11.73" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00468" "64981" "ENSG00000130312" "MRPL34" "hsa:64981; Q9BQ48" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.095" "1.036" "0.985" "0.997" "1.038" "1.023" "0.935" "1.069" "0.975" "340.2" "372.5" "352.3" "335.2" "339.3" "353.0" "348.1" "318.1" "363.5" "331.8" "" "" "" "" "" "" "" "" "" "" "273.2" "268.8" "279.9" "224.6" "234.7" "264.9" "243.7" "232.3" "363.5" "269.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8265724560765906942" "False" "High" "IsMasterProtein" "Q9BVP2" "Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2" "0.000" "False" "14.726" "10" "6" "6" "6" "549" "62.0" "9.16" "15.27" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf08701" "26354" "ENSG00000163938" "GNL3" "B2RDC1; hsa:26354; Q5PU80; Q96SV6; Q96SV7; Q9BVP2; Q9UJY0" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.349" "0.973" "1.100" "1.122" "1.191" "1.083" "1.027" "1.185" "1.077" "437.7" "590.6" "426.1" "481.4" "491.1" "521.2" "473.8" "449.4" "518.6" "471.3" "" "" "" "" "" "" "" "" "" "" "351.5" "426.1" "338.4" "322.5" "339.7" "391.1" "331.7" "328.2" "518.6" "383.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1189012646270467424" "False" "High" "IsMasterProtein" "Q9H5Q4" "Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1" "0.000" "False" "14.724" "13" "6" "6" "6" "396" "45.3" "9.19" "19.11" "6" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00398" "64216" "ENSG00000162851" "TFB2M" "hsa:64216; Q9H5Q4; Q9H626" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; Mitochondrial gene expression" "4" "0" "1.055" "1.097" "1.127" "1.149" "1.119" "1.057" "1.109" "1.072" "1.051" "1032.4" "1089.6" "1132.5" "1163.1" "1186.2" "1155.4" "1091.1" "1145.2" "1106.2" "1084.9" "" "" "" "" "" "" "" "" "" "" "829.2" "786.2" "899.5" "779.3" "820.4" "866.9" "763.9" "836.4" "1106.2" "882.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8351496581142553779" "False" "High" "IsMasterProtein" "Q12986" "Transcriptional repressor NF-X1 OS=Homo sapiens OX=9606 GN=NFX1 PE=1 SV=2" "0.000" "False" "14.715" "4" "3" "3" "3" "1120" "124.3" "8.24" "10.42" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01422, Pf01424" "4799" "ENSG00000086102" "NFX1" "A8K6H8; hsa:4799; Q12986; Q5VXW6; Q96EL5; Q9BXI1" "" "Fas ligand pathway and stress induction of heat shock proteins" "1" "0" "0.785" "0.874" "1.086" "0.973" "0.878" "1.007" "0.798" "0.830" "0.841" "113.0" "88.7" "98.8" "122.8" "110.0" "99.3" "113.8" "90.2" "93.8" "95.1" "" "" "" "" "" "" "" "" "" "" "90.8" "64.0" "78.4" "82.3" "76.1" "74.5" "79.7" "65.9" "93.8" "77.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6484824469682462574" "False" "High" "IsMasterProtein" "Q17R31" "Putative deoxyribonuclease TATDN3 OS=Homo sapiens OX=9606 GN=TATDN3 PE=1 SV=1" "0.000" "False" "14.707" "13" "3" "3" "3" "274" "30.3" "7.15" "11.60" "3" "" "nucleus" "other molecular function" "Pf01026" "128387" "ENSG00000203705" "TATDN3" "A6NGS3; B7Z1C1; B7Z978; B7ZLQ6; E9PJE5; E9PNH3; G3V151; hsa:128387; Q17R31; Q4G0L1" "" "" "0" "0" "1.097" "1.007" "1.048" "1.038" "1.128" "0.889" "0.909" "0.977" "1.021" "292.3" "320.6" "294.3" "306.2" "303.4" "329.8" "259.9" "265.8" "285.6" "298.3" "" "" "" "" "" "" "" "" "" "" "234.8" "231.3" "233.8" "205.1" "209.8" "247.4" "181.9" "194.1" "285.6" "242.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9076326979726242055" "False" "High" "IsMasterProtein" "Q9P2K6" "Kelch-like protein 42 OS=Homo sapiens OX=9606 GN=KLHL42 PE=1 SV=2" "0.000" "False" "14.698" "9" "4" "5" "4" "505" "56.8" "5.74" "15.84" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf01344, Pf07707" "57542" "ENSG00000087448" "KLHL42" "hsa:57542; Q2VPK1; Q8N334; Q9P2K6" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.032" "0.860" "1.139" "1.087" "1.031" "1.142" "1.090" "1.032" "1.057" "127.1" "131.1" "109.3" "144.8" "138.2" "131.0" "145.1" "138.5" "131.2" "134.3" "" "" "" "" "" "" "" "" "" "" "102.1" "94.6" "86.8" "97.0" "95.6" "98.3" "101.6" "101.2" "131.2" "109.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6084938480373239837" "False" "High" "IsMasterProtein" "O15525" "Transcription factor MafG OS=Homo sapiens OX=9606 GN=MAFG PE=1 SV=1" "0.000" "False" "14.683" "24" "5" "6" "2" "162" "17.8" "10.04" "19.35" "5" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03131" "4097" "ENSG00000197063" "MAFG" "hsa:4097; O15525" "Factors involved in megakaryocyte development and platelet production; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Ethanol metabolism production of ROS by CYP2E1; Rubinstein-Taybi syndrome 1" "8" "2" "1.132" "1.036" "1.082" "1.102" "1.154" "1.027" "1.049" "1.003" "1.102" "263.1" "297.8" "272.5" "284.8" "290.0" "303.6" "270.2" "276.1" "264.1" "290.0" "" "" "" "" "" "" "" "" "" "" "211.4" "214.9" "216.5" "190.8" "200.5" "227.8" "189.2" "201.6" "264.1" "235.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1775190888259302728" "False" "High" "IsMasterProtein" "Q6P2C8" "Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens OX=9606 GN=MED27 PE=1 SV=1" "0.000" "False" "14.656" "18" "4" "5" "4" "311" "35.4" "9.31" "16.19" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf11571" "9442" "ENSG00000160563" "MED27" "hsa:9442; O95401; Q4F964; Q5VTA4; Q5VTA5; Q6P2C8; Q9BU57; Q9NYR4; V9GYV9" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.197" "1.166" "1.107" "0.887" "1.159" "1.037" "1.103" "1.220" "1.214" "55.4" "66.4" "64.6" "61.4" "49.2" "64.2" "57.5" "61.2" "67.6" "67.3" "" "" "" "" "" "" "" "" "" "" "44.5" "47.9" "51.3" "41.1" "34.0" "48.2" "40.3" "44.7" "67.6" "54.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-357583033537535039" "False" "High" "IsMasterProtein" "Q9NX20" "Large ribosomal subunit protein uL16m OS=Homo sapiens OX=9606 GN=MRPL16 PE=1 SV=1" "0.000" "False" "14.655" "15" "3" "4" "3" "251" "28.4" "10.13" "13.66" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00252" "54948" "ENSG00000166902" "MRPL16" "hsa:54948; Q9BYD0; Q9HB70; Q9NX20" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.012" "1.057" "0.908" "0.957" "0.955" "0.868" "0.828" "0.949" "0.875" "176.5" "178.6" "186.6" "160.3" "168.9" "168.6" "153.2" "146.2" "167.5" "154.5" "" "" "" "" "" "" "" "" "" "" "141.8" "128.8" "148.2" "107.4" "116.8" "126.5" "107.3" "106.8" "167.5" "125.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361129451004350538" "False" "High" "IsMasterProtein" "Q9H0K1" "Serine/threonine-protein kinase SIK2 OS=Homo sapiens OX=9606 GN=SIK2 PE=1 SV=1" "0.000" "False" "14.649" "4" "4" "5" "4" "926" "103.8" "6.02" "15.54" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "23235" "ENSG00000170145" "SIK2" "A8K5B8; B0YJ94; hsa:23235; O94878; Q17RV0; Q6AZE2; Q76N03; Q8NCV7; Q96CZ8; Q9H0K1" "" "" "0" "0" "0.965" "0.931" "1.065" "0.936" "0.994" "0.997" "0.942" "1.024" "0.909" "350.9" "338.8" "326.6" "373.6" "328.4" "349.0" "350.0" "330.5" "359.3" "319.1" "" "" "" "" "" "" "" "" "" "" "281.9" "244.5" "259.4" "250.3" "227.1" "261.9" "245.1" "241.4" "359.3" "259.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1467078136555344062" "False" "High" "IsMasterProtein" "Q8NHZ8" "Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1" "0.000" "False" "14.641" "36" "2" "5" "2" "85" "9.8" "6.81" "14.68" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10471" "246184" "ENSG00000176386" "CDC26" "hsa:246184; Q8NHZ8" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "18" "0" "1.193" "1.060" "1.066" "1.116" "1.120" "1.241" "1.259" "1.279" "1.118" "292.9" "349.5" "310.4" "312.4" "326.8" "328.2" "363.6" "368.8" "374.6" "327.4" "" "" "" "" "" "" "" "" "" "" "235.3" "252.2" "246.6" "209.3" "226.0" "246.3" "254.6" "269.3" "374.6" "266.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3376743551660886452" "False" "High" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "0.000" "False" "14.606" "31" "4" "4" "4" "163" "17.6" "10.30" "12.90" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "0.916" "0.926" "0.907" "0.950" "0.956" "0.944" "0.952" "0.896" "0.976" "367.1" "336.2" "340.1" "333.1" "348.7" "351.0" "346.7" "349.6" "328.9" "358.2" "" "" "" "" "" "" "" "" "" "" "294.9" "242.6" "270.2" "223.2" "241.2" "263.4" "242.8" "255.3" "328.9" "291.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1010665989767425721" "False" "High" "IsMasterProtein" "Q96CS3" "FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2" "0.000" "False" "14.603" "8" "3" "3" "3" "445" "52.6" "5.62" "9.73" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "23197" "ENSG00000113194" "FAF2" "hsa:23197; O94963; Q8IUF2; Q96CS3; Q9BRP2; Q9BVM7" "Neutrophil degranulation; RHOA GTPase cycle" "5q35 copy number variation" "3" "0" "1.084" "0.969" "1.065" "1.014" "1.285" "1.118" "1.072" "1.250" "1.152" "175.3" "190.1" "169.9" "186.7" "177.9" "225.3" "196.0" "188.0" "219.1" "202.1" "" "" "" "" "" "" "" "" "" "" "140.8" "137.2" "135.0" "125.1" "123.0" "169.0" "137.2" "137.3" "219.1" "164.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3286506536231380161" "False" "High" "IsMasterProtein" "Q9NZI7" "Upstream-binding protein 1 OS=Homo sapiens OX=9606 GN=UBP1 PE=1 SV=1" "0.000" "False" "14.563" "6" "2" "3" "2" "540" "60.5" "6.35" "8.62" "2" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04516, Pf18016" "7342" "ENSG00000153560" "UBP1" "hsa:7342; Q68CT0; Q86Y57; Q9H8V0; Q9NZI7; Q9UD76; Q9UD78" "" "" "0" "0" "1.088" "1.093" "1.107" "1.292" "1.002" "1.083" "1.165" "1.018" "1.050" "83.6" "91.0" "91.4" "92.5" "108.0" "83.8" "90.6" "97.4" "85.1" "87.8" "" "" "" "" "" "" "" "" "" "" "67.2" "65.7" "72.6" "62.0" "74.7" "62.8" "63.4" "71.1" "85.1" "71.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8314583423527293992" "False" "High" "IsMasterProtein" "Q96SZ6" "Mitochondrial tRNA methylthiotransferase CDK5RAP1 OS=Homo sapiens OX=9606 GN=CDK5RAP1 PE=1 SV=2" "0.000" "False" "14.553" "7" "4" "4" "4" "601" "67.6" "8.21" "15.28" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00919, Pf01938, Pf04055" "51654" "ENSG00000101391" "CDK5RAP1" "A8K7R0; hsa:51654; Q5QP46; Q5QP47; Q5QP48; Q675N4; Q675N5; Q96SZ6; Q9BVG6; Q9BWZ5; Q9H859; Q9NZZ9; Q9Y3F0" "" "" "0" "0" "1.096" "1.070" "1.046" "1.097" "0.841" "0.981" "1.006" "0.973" "1.048" "214.5" "235.2" "229.6" "224.4" "235.3" "180.4" "210.4" "215.8" "208.8" "224.8" "" "" "" "" "" "" "" "" "" "" "172.3" "169.7" "182.3" "150.3" "162.7" "135.4" "147.3" "157.6" "208.8" "182.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4404494894943398685" "False" "High" "IsMasterProtein" "Q6P5R6" "Ribosomal protein eL22-like OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2" "0.000" "False" "14.552" "33" "4" "8" "4" "122" "14.6" "9.38" "23.49" "4" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01776" "200916" "ENSG00000163584" "RPL22L1" "hsa:200916; Q32Q77; Q6P5R6" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "13" "0" "0.951" "1.112" "1.101" "1.047" "1.089" "1.204" "1.029" "1.065" "1.072" "421.9" "401.1" "469.4" "464.3" "441.7" "459.4" "508.0" "434.0" "449.5" "452.4" "" "" "" "" "" "" "" "" "" "" "338.9" "289.4" "372.8" "311.1" "305.5" "344.7" "355.7" "316.9" "449.5" "367.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590032029601755120" "False" "High" "IsMasterProtein" "O75935" "Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1" "0.000" "False" "14.549" "26" "6" "6" "6" "186" "21.1" "5.47" "18.72" "6" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07426" "11258" "ENSG00000137100" "DCTN3" "A6NII7; B2RBM5; hsa:11258; O75935; Q5T1I5; Q5T1I7; Q5T8G3; Q9BPU8" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "11" "0" "1.078" "1.097" "0.992" "1.038" "1.031" "0.975" "0.957" "1.015" "1.006" "504.0" "543.4" "553.1" "500.2" "523.1" "519.4" "491.6" "482.1" "511.6" "507.1" "" "" "" "" "" "" "" "" "" "" "404.8" "392.1" "439.3" "335.1" "361.8" "389.7" "344.2" "352.1" "511.6" "412.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2149131157478544716" "False" "High" "IsMasterProtein" "Q6P587" "Oxaloacetate tautomerase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=3" "0.000" "False" "14.532" "20" "4" "4" "4" "221" "24.5" "7.39" "13.04" "4" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.067" "1.060" "1.118" "1.063" "1.023" "0.953" "0.874" "0.982" "1.075" "272.1" "290.5" "288.5" "304.3" "289.2" "278.3" "259.3" "237.9" "267.2" "292.5" "" "" "" "" "" "" "" "" "" "" "218.6" "209.6" "229.2" "203.9" "200.0" "208.8" "181.5" "173.7" "267.2" "237.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900413936480429684" "False" "High" "IsMasterProtein" "Q9Y6I4" "Ubiquitin carboxyl-terminal hydrolase 3 OS=Homo sapiens OX=9606 GN=USP3 PE=1 SV=2" "0.000" "False" "14.530" "7" "3" "3" "3" "520" "58.9" "8.18" "12.59" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00443, Pf02148" "9960" "ENSG00000140455" "USP3" "B4DVU5; F5H1A6; hsa:9960; Q8WVD0; Q9Y6I4" "Ub-specific processing proteases" "" "1" "0" "1.123" "1.169" "1.077" "1.073" "1.138" "1.009" "1.033" "1.152" "1.152" "205.3" "230.6" "239.9" "221.2" "220.2" "233.6" "207.1" "212.0" "236.6" "236.6" "" "" "" "" "" "" "" "" "" "" "164.9" "166.4" "190.6" "148.2" "152.3" "175.3" "145.0" "154.9" "236.6" "192.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119183533352449248" "False" "High" "IsMasterProtein" "Q9P0P8" "Mitochondrial transcription rescue factor 1 OS=Homo sapiens OX=9606 GN=MTRES1 PE=1 SV=1" "0.000" "False" "14.511" "11" "3" "4" "3" "240" "27.9" "9.29" "10.43" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "" "51250" "ENSG00000130349" "MTRES1" "B3KRG9; hsa:51250; Q9P0P8" "" "" "0" "0" "0.993" "1.064" "0.984" "1.033" "1.002" "0.933" "1.030" "1.088" "0.961" "330.7" "328.5" "351.9" "325.4" "341.7" "331.5" "308.7" "340.7" "359.7" "317.8" "" "" "" "" "" "" "" "" "" "" "265.7" "237.0" "279.5" "218.0" "236.3" "248.7" "216.2" "248.8" "359.7" "258.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731274812714259147" "False" "High" "IsMasterProtein" "Q9NYJ8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Homo sapiens OX=9606 GN=TAB2 PE=1 SV=1" "0.000" "False" "14.509" "4" "2" "2" "2" "693" "76.4" "8.54" "9.60" "2" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02845" "23118" "ENSG00000055208" "TAB2" "B2RCC4; E1P5A0; hsa:23118; O94838; Q6I9W8; Q76N06; Q9NYJ8; Q9UFP7" "Downstream TCR signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Nuclear signaling by ERBB4; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; TLR4 signaling and tolerance; Exercise-induced circadian regulation; miRNA role in immune response in sepsis; Measles virus infection; Hepatitis B infection; Toll-like receptor signaling pathway" "27" "0" "0.959" "1.097" "1.013" "1.252" "1.054" "0.958" "0.941" "1.099" "1.336" "41.7" "40.0" "45.7" "42.2" "52.2" "43.9" "39.9" "39.2" "45.8" "55.7" "" "" "" "" "" "" "" "" "" "" "33.5" "28.8" "36.3" "28.3" "36.1" "33.0" "27.9" "28.6" "45.8" "45.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-995658337958950277" "False" "High" "IsMasterProtein" "Q9HB09" "Bcl-2-like protein 12 OS=Homo sapiens OX=9606 GN=BCL2L12 PE=1 SV=2" "0.000" "False" "14.500" "12" "3" "4" "3" "250" "26.9" "5.72" "12.55" "3" "other biological processes" "" "other molecular function" "" "" "ENSG00000126453" "BCL2L12" "A0A087WSV0" "" "Regulation of apoptosis by parathyroid hormone-related protein" "1" "0" "1.270" "1.086" "1.368" "1.415" "1.307" "1.230" "1.193" "1.296" "1.374" "86.2" "109.4" "93.6" "117.9" "121.9" "112.7" "106.0" "102.8" "111.7" "118.4" "" "" "" "" "" "" "" "" "" "" "69.2" "78.9" "74.4" "79.0" "84.3" "84.5" "74.2" "75.1" "111.7" "96.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4297435359722797915" "False" "High" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "0.000" "False" "14.495" "8" "4" "4" "4" "562" "62.6" "8.21" "11.74" "4" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Synthesis of PIPs at the plasma membrane" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "4" "0" "0.936" "0.915" "0.828" "1.005" "1.003" "0.921" "0.983" "0.943" "1.024" "335.2" "313.7" "306.5" "277.6" "336.8" "336.1" "308.5" "329.5" "316.0" "343.0" "" "" "" "" "" "" "" "" "" "" "269.2" "226.3" "243.5" "186.0" "232.9" "252.1" "216.0" "240.7" "316.0" "279.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3499966319797164374" "False" "High" "IsMasterProtein" "Q9UKZ1" "CCR4-NOT transcription complex subunit 11 OS=Homo sapiens OX=9606 GN=CNOT11 PE=1 SV=1" "0.000" "False" "14.488" "6" "3" "4" "3" "510" "55.2" "6.40" "13.80" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10155" "55571" "ENSG00000158435" "CNOT11" "hsa:55571; Q6P2M9; Q8N681; Q9UKZ1" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "1.029" "1.024" "1.051" "1.078" "1.018" "1.053" "1.082" "1.102" "1.071" "687.5" "707.2" "703.9" "722.2" "741.4" "700.2" "723.8" "743.7" "757.9" "736.3" "" "" "" "" "" "" "" "" "" "" "552.2" "510.3" "559.1" "483.9" "512.7" "525.3" "506.8" "543.1" "757.9" "598.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3454207587848358751" "False" "High" "IsMasterProtein" "Q9UMN6" "Histone-lysine N-methyltransferase 2B OS=Homo sapiens OX=9606 GN=KMT2B PE=1 SV=1" "0.000" "False" "14.486" "1" "3" "3" "3" "2715" "293.3" "8.22" "11.05" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771" "9757" "ENSG00000272333" "KMT2B" "hsa:9757; O15022; O95836; Q96GP2; Q96IP3; Q9UK25; Q9UMN6; Q9Y668; Q9Y669" "PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "Histone modifications" "4" "0" "1.069" "1.107" "0.994" "1.066" "1.103" "1.044" "1.014" "1.055" "1.079" "198.8" "212.6" "220.1" "197.6" "212.0" "219.2" "207.6" "201.5" "209.7" "214.6" "" "" "" "" "" "" "" "" "" "" "159.7" "153.4" "174.8" "132.4" "146.6" "164.5" "145.4" "147.2" "209.7" "174.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6354667477089484627" "False" "High" "IsMasterProtein" "Q5T2E6" "Armadillo-like helical domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARMH3 PE=1 SV=1" "0.000" "False" "14.473" "6" "4" "5" "4" "689" "78.7" "6.60" "15.10" "4" "other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf08427" "79591" "ENSG00000120029" "ARMH3" "hsa:79591; Q2TB87; Q5T2E6; Q9H8Z9" "" "" "0" "0" "1.139" "1.016" "1.130" "1.138" "1.121" "1.020" "0.961" "1.191" "1.102" "484.0" "551.1" "491.7" "546.9" "550.6" "542.7" "493.9" "465.1" "576.4" "533.5" "" "" "" "" "" "" "" "" "" "" "388.7" "397.7" "390.5" "366.4" "380.8" "407.2" "345.8" "339.7" "576.4" "433.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-212858070142576811" "False" "High" "IsMasterProtein" "Q86VX2" "COMM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=COMMD7 PE=1 SV=2" "0.000" "False" "14.463" "17" "3" "4" "3" "200" "22.5" "5.92" "16.37" "3" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf07258, Pf21672" "149951" "ENSG00000149600" "COMMD7" "A2BHJ2; B3KTZ2; hsa:149951; Q5JYB0; Q86VX2; Q96SI7; Q9BW53" "Neddylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2065184215663256400" "False" "High" "IsMasterProtein" "Q5TKA1" "Protein lin-9 homolog OS=Homo sapiens OX=9606 GN=LIN9 PE=1 SV=1" "0.000" "False" "14.459" "6" "2" "2" "2" "542" "61.9" "9.04" "9.95" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06584, Pf19438" "286826" "ENSG00000183814" "LIN9" "hsa:286826; Q5TKA1; Q5U5L8; Q5U7E1; Q6PI55; Q6ZTV4; Q7Z3J1" "G1/S-Specific Transcription; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Gastric cancer network 1; DYRK1A involvement regarding cell proliferation in brain development" "9" "0" "1.056" "0.924" "0.967" "0.928" "0.946" "0.916" "0.975" "0.964" "0.943" "311.8" "329.2" "288.0" "301.5" "289.2" "294.9" "285.6" "304.1" "300.5" "294.1" "" "" "" "" "" "" "" "" "" "" "250.4" "237.5" "228.8" "202.0" "200.0" "221.3" "200.0" "222.1" "300.5" "239.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417113921000243817" "False" "High" "IsMasterProtein" "Q5JPI3" "Uncharacterized protein C3orf38 OS=Homo sapiens OX=9606 GN=C3orf38 PE=1 SV=1" "0.000" "False" "14.455" "16" "4" "4" "4" "329" "37.5" "6.47" "13.90" "4" "other biological processes" "nucleus" "" "Pf15008" "285237" "ENSG00000179021" "C3orf38" "B2R8X6; hsa:285237; Q5JPI3; Q8TC85" "" "" "0" "0" "0.428" "0.744" "0.889" "0.655" "0.677" "1.001" "0.786" "0.950" "0.584" "17.0" "7.3" "12.7" "15.1" "11.1" "11.5" "17.0" "13.4" "16.2" "9.9" "" "" "" "" "" "" "" "" "" "" "13.7" "5.2" "10.1" "10.1" "7.7" "8.6" "11.9" "9.8" "16.2" "8.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5372839880175933062" "False" "High" "IsMasterProtein" "Q9NUK0" "Muscleblind-like protein 3 OS=Homo sapiens OX=9606 GN=MBNL3 PE=1 SV=2" "0.000" "False" "14.453" "10" "4" "6" "2" "354" "38.5" "8.81" "19.22" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf14608, Pf18044" "55796" "ENSG00000076770" "MBNL3" "hsa:55796; Q5JXN8; Q5JXN9; Q5JXP4; Q6UDQ1; Q8IUR4; Q8TAD9; Q8TAF4; Q9H0Z7; Q9NUK0; Q9UF37" "" "" "0" "0" "0.924" "1.159" "1.219" "0.973" "0.968" "0.938" "0.923" "0.894" "1.068" "105.0" "97.0" "121.6" "128.0" "102.1" "101.6" "98.4" "96.9" "93.8" "112.1" "" "" "" "" "" "" "" "" "" "" "84.3" "70.0" "96.6" "85.7" "70.6" "76.2" "68.9" "70.8" "93.8" "91.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3737855785058777273" "False" "High" "IsMasterProtein" "Q9NSP4" "Centromere protein M OS=Homo sapiens OX=9606 GN=CENPM PE=1 SV=1" "0.000" "False" "14.452" "17" "3" "3" "3" "180" "19.7" "7.20" "11.16" "3" "cell cycle OR cell proliferation" "cytosol;nucleus;other cell component" "" "Pf11111" "79019" "ENSG00000100162" "CENPM" "A7LM22; B1AHQ9; hsa:79019; Q6I9W3; Q9NSP4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "0.889" "0.936" "0.879" "0.748" "0.788" "0.744" "0.764" "0.787" "0.732" "92.5" "82.2" "86.6" "81.3" "69.2" "72.9" "68.9" "70.7" "72.8" "67.7" "" "" "" "" "" "" "" "" "" "" "74.3" "59.3" "68.8" "54.5" "47.9" "54.7" "48.2" "51.6" "72.8" "55.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5352136499893616615" "False" "High" "IsMasterProtein" "O95219" "Sorting nexin-4 OS=Homo sapiens OX=9606 GN=SNX4 PE=1 SV=1" "0.000" "False" "14.428" "10" "4" "4" "4" "450" "51.9" "5.99" "11.72" "4" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787" "8723" "ENSG00000114520" "SNX4" "B3KMH0; B4DQV4; D3DNA3; hsa:8723; O95219" "" "" "0" "0" "1.062" "0.990" "1.111" "1.130" "1.035" "1.051" "1.070" "1.064" "1.033" "339.0" "360.1" "335.7" "376.6" "383.0" "351.0" "356.4" "362.8" "360.7" "350.2" "" "" "" "" "" "" "" "" "" "" "272.3" "259.8" "266.7" "252.3" "264.9" "263.4" "249.6" "265.0" "360.7" "284.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3393024407889637945" "False" "High" "IsMasterProtein" "P63027" "Vesicle-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=VAMP2 PE=1 SV=3" "0.000" "False" "14.416" "34" "3" "4" "3" "116" "12.7" "8.13" "12.98" "3" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6844" "ENSG00000220205" "VAMP2" "hsa:6844; P19065; P63027; Q9BUC2" "Sensory processing of sound by inner hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Glutamate Neurotransmitter Release Cycle; Regulation of insulin secretion; Insulin processing; Cargo recognition for clathrin-mediated endocytosis; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Vasopressin-regulated water reabsorption; Sudden infant death syndrome (SIDS) susceptibility pathways" "28" "0" "1.051" "0.926" "0.946" "0.926" "0.894" "1.028" "0.851" "0.913" "0.899" "357.4" "375.6" "331.0" "338.1" "330.9" "319.4" "367.5" "304.1" "326.2" "321.5" "" "" "" "" "" "" "" "" "" "" "287.1" "271.0" "262.9" "226.5" "228.9" "239.6" "257.3" "222.1" "326.2" "261.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1892003299666365822" "False" "High" "IsMasterProtein" "P60484" "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1" "0.000" "False" "14.411" "7" "3" "3" "3" "403" "47.1" "6.37" "11.78" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00102, Pf10409" "5728" "ENSG00000171862; ENSG00000284792" "PTEN" "B2R904; F2YHV0; O00633; O02679; P60484; Q6ICT7" "TP53 Regulates Metabolic Genes; Regulation of PTEN stability and activity; Downstream TCR signaling; Ub-specific processing proteases; Transcriptional Regulation by MECP2; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Ovarian tumor domain proteases; Negative regulation of the PI3K/AKT network; Regulation of PTEN localization; PTEN Loss of Function in Cancer; Regulation of PTEN mRNA translation" "Androgen receptor signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; T cell receptor and co-stimulatory signaling; Focal adhesion; Hepatocyte growth factor receptor signaling; Copper homeostasis; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Breast cancer pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; DNA damage response (only ATM dependent)" "55" "0" "1.035" "1.035" "1.039" "1.020" "1.112" "0.992" "0.990" "1.059" "1.016" "548.7" "567.9" "567.8" "570.3" "559.9" "610.0" "544.4" "543.4" "581.1" "557.3" "" "" "" "" "" "" "" "" "" "" "440.7" "409.8" "451.0" "382.1" "387.2" "457.7" "381.2" "396.9" "581.1" "453.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8193336255424769444" "False" "High" "IsMasterProtein" "Q92845" "Kinesin-associated protein 3 OS=Homo sapiens OX=9606 GN=KIFAP3 PE=1 SV=2" "0.000" "False" "14.409" "3" "2" "3" "2" "792" "91.1" "5.08" "9.74" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05804" "22920" "ENSG00000075945" "KIFAP3" "B1AKU4; B1AKU5; B2RDL1; B7Z8A3; F5H591; hsa:22920; Q8NHU7; Q92845; Q9H416" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "Genes related to primary cilium development (based on CRISPR)" "6" "0" "1.325" "1.321" "1.333" "1.292" "1.151" "1.285" "1.194" "1.287" "1.250" "100.9" "133.8" "133.4" "134.6" "130.4" "116.2" "129.7" "120.5" "129.9" "126.2" "" "" "" "" "" "" "" "" "" "" "81.1" "96.5" "105.9" "90.2" "90.2" "87.2" "90.8" "88.0" "129.9" "102.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3640417393520932039" "False" "High" "IsMasterProtein" "Q9P031" "Thyroid transcription factor 1-associated protein 26 OS=Homo sapiens OX=9606 GN=CCDC59 PE=1 SV=2" "0.000" "False" "14.406" "14" "3" "4" "3" "241" "28.7" "9.88" "15.41" "3" "" "nucleus" "" "Pf08524" "29080" "ENSG00000133773" "CCDC59" "hsa:29080; Q9H2V5; Q9NW62; Q9P031" "Surfactant metabolism" "" "1" "0" "1.028" "0.992" "0.983" "0.983" "0.976" "0.931" "0.895" "0.927" "1.028" "692.4" "711.6" "686.8" "680.7" "680.8" "675.6" "644.6" "620.0" "641.8" "712.0" "" "" "" "" "" "" "" "" "" "" "556.1" "513.5" "545.5" "456.1" "470.9" "506.9" "451.3" "452.8" "641.8" "579.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7866416472238112790" "False" "High" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "0.000" "False" "14.398" "32" "2" "3" "2" "63" "6.9" "7.24" "12.22" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Mitochondrial protein import" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "5" "0" "1.089" "1.122" "0.832" "0.934" "1.214" "0.941" "0.995" "1.100" "1.046" "301.1" "327.8" "337.8" "250.4" "281.3" "365.6" "283.5" "299.7" "331.3" "315.1" "" "" "" "" "" "" "" "" "" "" "241.8" "236.5" "268.3" "167.8" "194.5" "274.3" "198.5" "218.9" "331.3" "256.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1696656026908675474" "False" "High" "IsMasterProtein" "Q9BS40" "Latexin OS=Homo sapiens OX=9606 GN=LXN PE=1 SV=2" "0.000" "False" "14.392" "17" "4" "6" "4" "222" "25.7" "5.78" "11.67" "4" "stress response;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity;other molecular function" "Pf06907, Pf20630" "56925" "ENSG00000079257" "LXN" "hsa:56925; Q96PN2; Q9BS40; Q9NQS6" "" "" "0" "0" "0.985" "0.956" "1.020" "1.009" "0.945" "1.080" "1.043" "0.930" "0.935" "529.8" "521.8" "506.7" "540.5" "534.5" "500.9" "572.3" "552.9" "492.6" "495.5" "" "" "" "" "" "" "" "" "" "" "425.6" "376.5" "402.5" "362.1" "369.7" "375.8" "400.7" "403.8" "492.6" "402.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3150532128508731386" "False" "High" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "0.000" "False" "14.392" "6" "2" "3" "2" "376" "42.5" "5.57" "9.54" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "mRNA Splicing - Major Pathway" "" "1" "0" "1.077" "1.221" "0.928" "1.128" "1.261" "1.244" "1.250" "1.131" "1.113" "116.8" "125.8" "142.6" "108.4" "131.8" "147.3" "145.3" "146.0" "132.2" "130.1" "" "" "" "" "" "" "" "" "" "" "93.8" "90.8" "113.3" "72.6" "91.2" "110.5" "101.7" "106.6" "132.2" "105.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144026174049458249" "False" "High" "IsMasterProtein" "Q99574" "Neuroserpin OS=Homo sapiens OX=9606 GN=SERPINI1 PE=1 SV=1" "0.000" "False" "14.382" "14" "5" "5" "5" "410" "46.4" "4.91" "11.85" "5" "developmental processes;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "5274" "ENSG00000163536" "SERPINI1" "A8K217; D3DNP1; hsa:5274; Q6AHZ4; Q99574" "" "" "0" "0" "1.107" "0.978" "1.229" "1.134" "0.998" "1.017" "1.022" "1.115" "1.080" "130.9" "144.9" "127.9" "160.8" "148.4" "130.5" "133.1" "133.7" "146.0" "141.4" "" "" "" "" "" "" "" "" "" "" "105.1" "104.5" "101.6" "107.7" "102.6" "97.9" "93.2" "97.6" "146.0" "115.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4134532342981628088" "False" "High" "IsMasterProtein" "Q9BSV6" "tRNA-splicing endonuclease subunit Sen34 OS=Homo sapiens OX=9606 GN=TSEN34 PE=1 SV=1" "0.000" "False" "14.370" "9" "2" "2" "2" "310" "33.6" "8.43" "10.63" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01974" "79042" "ENSG00000170892; ENSG00000273896; ENSG00000274078; ENSG00000274129; ENSG00000274672; ENSG00000274796; ENSG00000275165; ENSG00000278605; ENSG00000278622; ENSG00000278712" "TSEN34" "A6NNB1; B0V3J1; hsa:79042; Q9BSV6; Q9BVT1; Q9H6H5" "tRNA processing in the nucleus" "" "1" "0" "0.930" "0.949" "0.989" "1.034" "1.178" "0.892" "1.042" "1.012" "1.102" "63.9" "59.4" "60.7" "63.2" "66.1" "75.2" "57.0" "66.6" "64.7" "70.4" "" "" "" "" "" "" "" "" "" "" "51.3" "42.9" "48.2" "42.3" "45.7" "56.5" "39.9" "48.6" "64.7" "57.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7821443227356319074" "False" "High" "IsMasterProtein" "Q96EL2" "Small ribosomal subunit protein uS3m OS=Homo sapiens OX=9606 GN=MRPS24 PE=1 SV=1" "0.000" "False" "14.367" "23" "3" "3" "3" "167" "19.0" "9.38" "7.54" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf14955" "64951" "ENSG00000062582" "MRPS24" "A4D1U9; hsa:64951; P82668; Q96EL2; Q96Q23; Q9P047" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2541081725476023529" "False" "High" "IsMasterProtein" "Q8NBJ7" "Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2" "0.000" "False" "14.364" "23" "6" "6" "6" "301" "33.8" "8.00" "15.03" "6" "" "ER/Golgi" "other molecular function" "Pf03781" "25870" "ENSG00000129103" "SUMF2" "B4DU41; B4DWQ0; hsa:25870; Q14DW5; Q53ZE3; Q8NBJ7; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405" "Glycosphingolipid catabolism; The activation of arylsulfatases" "" "2" "0" "0.961" "0.917" "1.028" "1.028" "0.971" "1.066" "1.080" "1.062" "1.015" "608.6" "585.1" "558.2" "625.5" "625.4" "590.8" "648.6" "657.2" "646.0" "617.6" "" "" "" "" "" "" "" "" "" "" "488.8" "422.2" "443.4" "419.1" "432.5" "443.3" "454.1" "479.9" "646.0" "502.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047850882453787868" "False" "High" "IsMasterProtein" "Q96S19" "Methyltransferase-like 26 OS=Homo sapiens OX=9606 GN=METTL26 PE=1 SV=2" "0.000" "False" "14.356" "11" "2" "3" "2" "204" "22.6" "7.83" "9.73" "2" "" "" "other molecular function" "Pf06080" "84326" "ENSG00000130731" "METTL26" "A8MTR1; A8MWJ8; A8MZA1; B4DG95; B4DIJ3; D6REA6; F6TF62; F6VM53; hsa:84326; Q96IW1; Q96MD6; Q96S19" "" "" "0" "0" "0.857" "1.000" "1.074" "1.374" "1.223" "1.149" "1.298" "1.216" "1.220" "270.1" "231.5" "270.2" "290.0" "370.9" "330.2" "310.3" "350.5" "328.4" "329.5" "" "" "" "" "" "" "" "" "" "" "216.9" "167.0" "214.6" "194.3" "256.5" "247.8" "217.3" "256.0" "328.4" "268.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1801185171268448485" "False" "High" "IsMasterProtein" "Q6NTE8" "MRN complex-interacting protein OS=Homo sapiens OX=9606 GN=MRNIP PE=1 SV=2" "0.000" "False" "14.349" "4" "1" "2" "1" "343" "37.7" "8.66" "9.60" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf15749" "51149" "ENSG00000161010; ENSG00000283918" "MRNIP" "B5MD09; E9PAK6; Q6NTE8; Q7Z3D8; Q9BUC1; Q9UN54" "" "" "0" "0" "1.124" "1.069" "0.975" "0.964" "0.842" "1.109" "1.179" "1.015" "1.020" "54.8" "61.6" "58.6" "53.4" "52.8" "46.1" "60.7" "64.6" "55.6" "55.9" "" "" "" "" "" "" "" "" "" "" "44.0" "44.4" "46.5" "35.8" "36.5" "34.6" "42.5" "47.2" "55.6" "45.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-273580326344755001" "False" "High" "IsMasterProtein" "P26885" "Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2" "0.000" "False" "14.337" "26" "3" "6" "3" "142" "15.6" "9.13" "21.23" "3" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00254" "2286" "ENSG00000173486" "FKBP2" "hsa:2286; P26885; Q5BJH9; Q9BTS7" "" "Complement system" "1" "0" "1.188" "1.097" "1.047" "0.947" "1.150" "1.068" "1.013" "1.074" "1.102" "296.6" "352.4" "325.4" "310.4" "281.0" "341.2" "316.8" "300.5" "318.5" "326.7" "" "" "" "" "" "" "" "" "" "" "238.2" "254.3" "258.5" "208.0" "194.3" "256.0" "221.8" "219.5" "318.5" "265.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6974141516308557016" "False" "High" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "0.000" "False" "14.337" "16" "4" "5" "4" "261" "28.1" "5.91" "15.42" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; O95638; Q969T9" "" "" "0" "0" "0.936" "0.988" "0.913" "0.991" "1.065" "0.999" "1.018" "1.069" "1.007" "731.1" "684.5" "722.0" "667.7" "724.2" "778.9" "730.7" "743.9" "781.5" "736.0" "" "" "" "" "" "" "" "" "" "" "587.2" "493.9" "573.5" "447.4" "500.9" "584.4" "511.6" "543.3" "781.5" "598.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "472644769200762840" "False" "High" "IsMasterProtein" "Q9UJK0" "18S rRNA aminocarboxypropyltransferase OS=Homo sapiens OX=9606 GN=TSR3 PE=1 SV=1" "0.000" "False" "14.311" "9" "2" "3" "2" "312" "33.6" "6.87" "8.91" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf04034, Pf04068" "115939" "ENSG00000007520" "TSR3" "hsa:115939; Q6PJT8; Q9UJK0" "rRNA modification in the nucleus and cytosol" "" "1" "0" "1.573" "1.149" "1.254" "1.113" "0.959" "1.321" "1.217" "1.261" "1.390" "12.4" "19.6" "14.3" "15.6" "13.8" "11.9" "16.4" "15.1" "15.7" "17.3" "" "" "" "" "" "" "" "" "" "" "10.0" "14.1" "11.4" "10.5" "9.6" "8.9" "11.5" "11.1" "15.7" "14.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660276496901993886" "False" "High" "IsMasterProtein" "Q96SY0" "Integrator complex subunit 14 OS=Homo sapiens OX=9606 GN=INTS14 PE=1 SV=2" "0.000" "False" "14.310" "7" "3" "3" "3" "518" "57.4" "5.12" "8.15" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13519, Pf19435, Pf20504" "81556" "ENSG00000138614" "INTS14" "B4DDI6; B4DVD5; hsa:81556; Q49AH8; Q96HX5; Q96SY0; Q9H0S5" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "0.973" "0.996" "0.896" "0.982" "1.054" "0.939" "0.981" "1.012" "1.045" "508.3" "494.8" "506.1" "455.5" "499.1" "535.7" "477.3" "498.8" "514.6" "530.9" "" "" "" "" "" "" "" "" "" "" "408.3" "357.0" "402.0" "305.2" "345.2" "401.9" "334.2" "364.3" "514.6" "431.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6216659800236310345" "False" "High" "IsMasterProtein" "Q9H1Z4" "WD repeat-containing protein 13 OS=Homo sapiens OX=9606 GN=WDR13 PE=1 SV=3" "0.000" "False" "14.282" "7" "2" "2" "2" "485" "53.7" "9.23" "10.35" "2" "other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus" "other molecular function" "Pf00400" "64743" "ENSG00000101940" "WDR13" "hsa:64743; Q06DW8; Q06DX0; Q06DX1; Q9BUL7; Q9H1Z4; Q9NWW4" "" "" "0" "0" "0.947" "0.894" "0.867" "1.011" "0.922" "0.890" "0.931" "0.882" "0.865" "215.6" "204.2" "192.7" "187.0" "217.9" "198.8" "191.9" "200.9" "190.3" "186.5" "" "" "" "" "" "" "" "" "" "" "173.2" "147.4" "153.1" "125.3" "150.7" "149.2" "134.4" "146.7" "190.3" "151.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1829057595259192676" "False" "High" "IsMasterProtein" "Q8ND83" "SLAIN motif-containing protein 1 OS=Homo sapiens OX=9606 GN=SLAIN1 PE=1 SV=3" "0.000" "False" "14.281" "9" "5" "6" "4" "568" "60.6" "7.64" "15.44" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf15301" "122060" "ENSG00000139737" "SLAIN1" "A8K0Z9; B7Z209; hsa:122060; Q5T6P4; Q5T6P7; Q8ND10; Q8ND83; Q96NV0" "" "" "0" "0" "1.004" "1.061" "1.054" "1.011" "0.969" "0.960" "1.059" "1.067" "1.016" "429.2" "431.1" "455.3" "452.5" "433.7" "416.1" "412.2" "454.6" "457.9" "435.9" "" "" "" "" "" "" "" "" "" "" "344.7" "311.1" "361.7" "303.2" "300.0" "312.2" "288.6" "332.0" "457.9" "354.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4237649288618835376" "False" "High" "IsMasterProtein" "Q9NUP9" "Protein lin-7 homolog C OS=Homo sapiens OX=9606 GN=LIN7C PE=1 SV=1" "0.000" "False" "14.269" "15" "3" "3" "3" "197" "21.8" "8.43" "6.83" "3" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf00595, Pf02828" "55327" "ENSG00000148943" "LIN7C" "hsa:55327; Q9NUP9" "Neurexins and neuroligins; Assembly and cell surface presentation of NMDA receptors; Dopamine Neurotransmitter Release Cycle" "" "3" "0" "1.090" "1.000" "0.959" "1.053" "1.119" "0.937" "0.985" "1.081" "0.969" "170.1" "185.4" "170.1" "163.2" "179.1" "190.3" "159.4" "167.7" "183.9" "164.9" "" "" "" "" "" "" "" "" "" "" "136.7" "133.8" "135.1" "109.3" "123.9" "142.8" "111.6" "122.4" "183.9" "134.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308082143838358470" "False" "High" "IsMasterProtein" "P42766" "Large ribosomal subunit protein uL29 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "0.000" "False" "14.262" "25" "4" "6" "4" "123" "14.5" "11.05" "21.09" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.816" "0.984" "0.896" "0.930" "0.943" "1.001" "0.847" "0.902" "0.965" "934.6" "762.3" "919.8" "837.6" "869.3" "880.9" "935.8" "791.4" "842.8" "902.2" "" "" "" "" "" "" "" "" "" "" "750.6" "550.1" "730.6" "561.2" "601.2" "660.9" "655.2" "577.9" "842.8" "733.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023891521044108187" "False" "High" "IsMasterProtein" "Q96BX8" "MOB kinase activator 3A OS=Homo sapiens OX=9606 GN=MOB3A PE=1 SV=1" "0.000" "False" "14.260" "18" "4" "4" "4" "217" "25.4" "8.63" "13.30" "4" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "126308" "ENSG00000172081" "MOB3A" "B3KTF1; hsa:126308; O75249; Q8TF69; Q96BX8" "" "" "0" "0" "1.093" "1.002" "0.917" "1.012" "0.916" "0.798" "0.989" "0.903" "0.906" "644.5" "704.3" "646.0" "591.3" "652.3" "590.5" "514.4" "637.3" "582.2" "583.7" "" "" "" "" "" "" "" "" "" "" "517.7" "508.2" "513.1" "396.2" "451.1" "443.0" "360.1" "465.5" "582.2" "474.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5100891898626735389" "False" "High" "IsMasterProtein" "Q86WA6" "Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1" "0.000" "False" "14.241" "14" "5" "5" "5" "291" "32.5" "9.14" "12.81" "5" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00561" "670" "ENSG00000137274" "BPHL" "hsa:670; Q00306; Q13855; Q3KP51; Q86WA6" "Phase I - Functionalization of compounds" "" "1" "0" "0.960" "1.005" "0.940" "0.941" "0.895" "0.997" "0.918" "0.868" "0.931" "281.3" "270.0" "282.7" "264.4" "264.7" "251.7" "280.4" "258.2" "244.2" "261.9" "" "" "" "" "" "" "" "" "" "" "225.9" "194.9" "224.5" "177.1" "183.1" "188.8" "196.3" "188.5" "244.2" "213.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4865533649162524419" "False" "High" "IsMasterProtein" "P28702" "Retinoic acid receptor RXR-beta OS=Homo sapiens OX=9606 GN=RXRB PE=1 SV=2" "0.000" "False" "14.232" "5" "3" "4" "3" "533" "56.9" "8.18" "11.84" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "6257" "ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712" "RXRB" "hsa:6257; P28702; P28703; Q59G65; Q5JP92; Q5STQ1" "PPARA activates gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis" "Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A1 and A5/X pathways; Vitamin A and carotenoid metabolism" "18" "0" "1.397" "1.048" "1.306" "1.231" "1.135" "1.071" "0.921" "1.122" "1.113" "158.4" "221.3" "166.0" "207.0" "195.0" "179.8" "169.7" "145.9" "177.7" "176.3" "" "" "" "" "" "" "" "" "" "" "127.2" "159.7" "131.8" "138.7" "134.8" "134.9" "118.8" "106.6" "177.7" "143.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-241917759717494375" "False" "High" "IsMasterProtein" "Q76I76" "Protein phosphatase Slingshot homolog 2 OS=Homo sapiens OX=9606 GN=SSH2 PE=1 SV=1" "0.000" "False" "14.228" "3" "4" "4" "4" "1423" "158.1" "5.41" "12.26" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00782, Pf08766" "85464" "ENSG00000141298" "SSH2" "hsa:85464; Q76I76; Q8TDB5; Q8WYL1; Q8WYL2; Q96F40; Q96H36; Q9C0D8" "" "Regulation of actin cytoskeleton" "1" "0" "0.906" "1.000" "0.993" "1.062" "0.964" "1.108" "0.977" "1.030" "1.055" "214.7" "194.5" "214.8" "213.2" "228.0" "207.0" "238.0" "209.9" "221.1" "226.5" "" "" "" "" "" "" "" "" "" "" "172.5" "140.3" "170.6" "142.9" "157.7" "155.3" "166.6" "153.3" "221.1" "184.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5249914492597377912" "False" "High" "IsMasterProtein" "Q8WV19" "Vesicle transport protein SFT2A OS=Homo sapiens OX=9606 GN=SFT2D1 PE=1 SV=1" "0.000" "False" "14.226" "17" "1" "1" "1" "159" "17.8" "8.65" "7.12" "1" "transport" "other membranes" "" "Pf04178" "113402" "ENSG00000198818" "SFT2D1" "hsa:113402; Q5TI64; Q8WV19; Q9UIC7" "" "" "0" "0" "0.680" "0.711" "0.786" "0.723" "0.682" "0.840" "0.540" "0.855" "0.769" "27.6" "18.7" "19.6" "21.7" "19.9" "18.8" "23.2" "14.9" "23.6" "21.2" "" "" "" "" "" "" "" "" "" "" "22.1" "13.5" "15.6" "14.5" "13.8" "14.1" "16.2" "10.9" "23.6" "17.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "57787487465406304" "False" "High" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "0.000" "False" "14.224" "6" "4" "5" "3" "709" "81.0" "6.87" "11.29" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292, Pf21092, Pf21103" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "" "12" "0" "1.053" "1.150" "1.352" "1.243" "1.205" "1.116" "1.277" "1.259" "1.276" "103.4" "108.9" "118.9" "139.8" "128.4" "124.6" "115.3" "132.0" "130.1" "131.9" "" "" "" "" "" "" "" "" "" "" "83.0" "78.6" "94.4" "93.6" "88.8" "93.5" "80.7" "96.4" "130.1" "107.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630996109560083637" "False" "High" "IsMasterProtein" "O75909" "Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2" "0.000" "False" "14.223" "7" "3" "4" "3" "580" "64.2" "8.41" "12.50" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf21797" "8812" "ENSG00000090061" "CCNK" "hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "Male infertility" "10" "0" "1.045" "1.009" "1.067" "1.106" "0.932" "1.079" "1.047" "1.037" "1.033" "299.1" "312.5" "301.8" "319.2" "330.9" "278.8" "322.7" "313.1" "310.1" "309.0" "" "" "" "" "" "" "" "" "" "" "240.2" "225.5" "239.8" "213.9" "228.8" "209.2" "225.9" "228.7" "310.1" "251.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3526658263404779392" "False" "High" "IsMasterProtein" "Q9UBI1" "COMM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=COMMD3 PE=1 SV=1" "0.000" "False" "14.203" "21" "4" "6" "4" "195" "22.1" "5.99" "14.55" "4" "transport" "non-structural extracellular;nucleus;other cell component" "" "Pf07258" "23412" "ENSG00000148444" "COMMD3" "D3DRU7; hsa:23412; Q5T8Y9; Q9UBI1" "Neutrophil degranulation; Neddylation" "" "2" "0" "0.993" "0.975" "1.032" "0.981" "0.911" "0.975" "0.926" "0.943" "0.995" "568.4" "564.5" "554.0" "586.3" "557.7" "517.8" "553.9" "526.1" "536.1" "565.5" "" "" "" "" "" "" "" "" "" "" "456.5" "407.3" "440.0" "392.8" "385.7" "388.5" "387.8" "384.2" "536.1" "459.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1197629715335020775" "False" "High" "IsMasterProtein" "Q02535" "DNA-binding protein inhibitor ID-3 OS=Homo sapiens OX=9606 GN=ID3 PE=1 SV=2" "0.000" "False" "14.201" "27" "2" "2" "2" "119" "13.0" "5.83" "7.35" "2" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00010" "3399" "ENSG00000117318; ENSG00000283060" "ID3" "A8K1T8; hsa:3399; O75641; Q02535" "NGF-stimulated transcription" "Adipogenesis; Orexin receptor pathway; ID signaling pathway" "4" "0" "1.020" "0.843" "1.077" "0.942" "0.871" "0.975" "0.811" "0.916" "0.982" "173.3" "176.8" "146.1" "186.7" "163.2" "151.0" "169.0" "140.6" "158.7" "170.1" "" "" "" "" "" "" "" "" "" "" "139.2" "127.6" "116.0" "125.1" "112.9" "113.3" "118.4" "102.7" "158.7" "138.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696215040566855502" "False" "High" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "0.000" "False" "14.199" "10" "3" "5" "3" "243" "27.9" "4.20" "13.82" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773, Pf16543" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "Protein hydroxylation" "" "1" "0" "1.140" "1.057" "1.043" "1.104" "1.009" "1.042" "0.947" "1.101" "1.049" "696.9" "794.4" "736.6" "727.1" "769.1" "703.1" "726.3" "659.7" "767.2" "731.2" "" "" "" "" "" "" "" "" "" "" "559.8" "573.2" "585.1" "487.2" "531.9" "527.6" "508.5" "481.8" "767.2" "594.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875234499947995187" "False" "High" "IsMasterProtein" "Q93100" "Phosphorylase b kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PHKB PE=1 SV=3" "0.000" "False" "14.181" "4" "5" "5" "5" "1093" "124.8" "6.95" "15.04" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00723, Pf19292" "5257" "ENSG00000102893" "PHKB" "hsa:5257; Q8N4T5; Q93100" "Glycogen breakdown (glycogenolysis)" "Glycogen synthesis and degradation" "2" "0" "0.973" "1.018" "1.075" "0.988" "1.003" "1.005" "0.954" "0.967" "1.005" "348.1" "338.7" "354.4" "374.0" "343.9" "349.0" "349.7" "332.2" "336.5" "349.8" "" "" "" "" "" "" "" "" "" "" "279.6" "244.4" "281.5" "250.6" "237.9" "261.9" "244.9" "242.6" "336.5" "284.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8783162572127248995" "False" "High" "IsMasterProtein" "Q9H4A5" "Golgi phosphoprotein 3-like OS=Homo sapiens OX=9606 GN=GOLPH3L PE=1 SV=1" "0.000" "False" "14.172" "15" "4" "5" "3" "285" "32.7" "5.83" "14.98" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf05719" "55204" "ENSG00000143457" "GOLPH3L" "B1AN09; B7Z6N3; hsa:55204; Q9H4A5; Q9NVK0" "" "" "0" "0" "0.984" "1.048" "1.171" "0.889" "1.108" "0.855" "0.824" "1.015" "0.906" "87.6" "86.2" "91.8" "102.6" "77.8" "97.0" "74.9" "72.2" "88.9" "79.4" "" "" "" "" "" "" "" "" "" "" "70.3" "62.2" "72.9" "68.7" "53.8" "72.8" "52.4" "52.7" "88.9" "64.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3981569091438122921" "False" "High" "IsMasterProtein" "Q8N4P3" "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3" "0.000" "False" "14.161" "17" "2" "3" "2" "179" "20.3" "6.74" "13.45" "2" "" "" "other molecular function" "Pf13328" "374659" "ENSG00000184508" "HDDC3" "hsa:374659; Q8N4P3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651135355279393622" "False" "High" "IsMasterProtein" "Q8N2G8" "GH3 domain-containing protein OS=Homo sapiens OX=9606 GN=GHDC PE=1 SV=2" "0.000" "False" "14.158" "8" "4" "4" "4" "530" "57.5" "7.88" "10.98" "4" "" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03321" "84514" "ENSG00000167925" "GHDC" "B4DQS4; E9PDB5; hsa:84514; Q8N2G8; Q9BXM6" "Neutrophil degranulation" "" "1" "0" "0.791" "0.778" "1.065" "0.973" "0.919" "0.950" "0.712" "0.838" "0.976" "85.3" "67.5" "66.4" "90.8" "83.0" "78.4" "81.1" "60.8" "71.4" "83.3" "" "" "" "" "" "" "" "" "" "" "68.5" "48.7" "52.7" "60.9" "57.4" "58.8" "56.8" "44.4" "71.4" "67.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8498450919961846637" "False" "High" "IsMasterProtein" "Q14315" "Filamin-C OS=Homo sapiens OX=9606 GN=FLNC PE=1 SV=3" "0.000" "False" "14.140" "2" "6" "6" "1" "2725" "290.8" "5.97" "10.81" "6" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2318" "ENSG00000128591" "FLNC" "B2ZZ88; hsa:2318; O95303; Q07985; Q14315; Q9NS12; Q9NYE5; Q9UMR8; Q9Y503" "Cell-extracellular matrix interactions" "Focal adhesion; MAPK signaling pathway; Ebola virus infection in host; NPHP1 deletion syndrome; 13q12.12 copy number variation" "6" "0" "1.172" "1.061" "1.031" "0.908" "1.058" "0.815" "1.088" "0.934" "1.022" "279.4" "327.5" "296.6" "288.0" "253.6" "295.7" "227.6" "304.1" "260.9" "285.5" "" "" "" "" "" "" "" "" "" "" "224.4" "236.3" "235.6" "193.0" "175.4" "221.9" "159.3" "222.1" "260.9" "232.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-180619704287479053" "False" "High" "IsMasterProtein" "P01137" "Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=3" "0.000" "False" "14.139" "10" "3" "3" "3" "390" "44.3" "8.53" "11.60" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00019, Pf00688" "7040" "ENSG00000105329" "TGFB1" "A8K792; hsa:7040; P01137; Q9UCG4" "Transcriptional regulation of white adipocyte differentiation; Cell surface interactions at the vascular wall; UCH proteinases; ECM proteoglycans; Platelet degranulation ; Regulation of RUNX3 expression and activity; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; Downregulation of TGF-beta receptor signaling; Molecules associated with elastic fibres; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates p14-ARF; Influenza Virus Induced Apoptosis; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; RUNX3 regulates CDKN1A transcription" "MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell cycle; Allograft rejection; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac progenitor differentiation; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Pluripotent stem cell differentiation pathway; Endoderm differentiation; Dopaminergic neurogenesis; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Lung fibrosis; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Clear cell renal cell carcinoma pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; Nonalcoholic fatty liver disease; Platelet-mediated interactions with vascular and circulating cells; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Signal transduction through IL1R; Envelope proteins and their potential roles in EDMD physiopathology; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; T cell modulation in pancreatic cancer; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Complement system in neuronal development and plasticity; Overview of proinflammatory and profibrotic mediators; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Ulcerative colitis signaling; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Comprehensive IL-17A signaling; Cell interactions of the pancreatic cancer microenvironment; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; 1p36 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; IL-19 signaling pathway; ACE inhibitor pathway; TGF-beta receptor signaling; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "95" "0" "1.060" "0.971" "1.030" "1.114" "1.076" "1.161" "1.119" "1.240" "1.207" "237.3" "251.4" "230.5" "244.5" "264.5" "255.4" "275.4" "265.5" "294.3" "286.5" "" "" "" "" "" "" "" "" "" "" "190.6" "181.4" "183.1" "163.8" "182.9" "191.6" "192.8" "193.9" "294.3" "233.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5802267777781672264" "False" "High" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "0.000" "False" "14.121" "20" "3" "5" "3" "181" "21.2" "7.49" "9.97" "3" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "G alpha (i) signalling events" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1635530099867829890" "False" "High" "IsMasterProtein" "Q86Y37" "CDK2-associated and cullin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CACUL1 PE=1 SV=1" "0.000" "False" "14.106" "6" "2" "3" "2" "369" "41.0" "5.19" "11.08" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00888" "143384" "ENSG00000151893" "CACUL1" "hsa:143384; Q5XPL7; Q86Y37; Q8IY11; Q8N7S4" "" "" "0" "0" "1.007" "1.022" "0.987" "1.048" "1.058" "0.985" "0.980" "1.128" "0.997" "373.0" "375.7" "381.3" "368.1" "390.9" "394.6" "367.5" "365.4" "420.7" "371.8" "" "" "" "" "" "" "" "" "" "" "299.6" "271.1" "302.9" "246.6" "270.4" "296.1" "257.3" "266.8" "420.7" "302.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4353551603118957972" "False" "High" "IsMasterProtein" "P34949" "Mannose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=MPI PE=1 SV=2" "0.000" "False" "14.103" "9" "3" "3" "3" "423" "46.6" "5.95" "9.44" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf01238, Pf20511, Pf20512" "4351" "ENSG00000178802" "MPI" "A8K8K9; hsa:4351; P34949; Q96AB0" "Synthesis of GDP-mannose; Defective MPI causes MPI-CDG" "N-glycan biosynthesis" "3" "0" "0.982" "0.932" "0.942" "0.963" "0.935" "0.927" "0.965" "1.013" "0.969" "240.5" "236.3" "224.1" "226.7" "231.7" "225.0" "222.9" "232.2" "243.6" "233.0" "" "" "" "" "" "" "" "" "" "" "193.2" "170.5" "178.0" "151.9" "160.2" "168.8" "156.1" "169.6" "243.6" "189.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3627252899551957156" "False" "High" "IsMasterProtein" "Q9NSC5" "Homer protein homolog 3 OS=Homo sapiens OX=9606 GN=HOMER3 PE=1 SV=2" "0.000" "False" "14.094" "11" "4" "4" "4" "361" "39.8" "5.45" "9.38" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9454" "ENSG00000051128" "HOMER3" "B2RA10; E9PCW9; hsa:9454; O14580; O95350; Q9NSB9; Q9NSC0; Q9NSC1; Q9NSC5" "Neurexins and neuroligins" "PKC-gamma calcium signaling pathway in ataxia; Cell lineage map for neuronal differentiation" "3" "0" "1.060" "1.038" "1.220" "0.951" "0.967" "1.055" "0.957" "1.045" "0.904" "117.2" "124.2" "121.6" "143.0" "111.5" "113.3" "123.7" "112.1" "122.5" "106.0" "" "" "" "" "" "" "" "" "" "" "94.1" "89.7" "96.6" "95.8" "77.1" "85.0" "86.6" "81.9" "122.5" "86.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6536357785872288465" "False" "High" "IsMasterProtein" "P48723" "Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1" "0.000" "False" "14.084" "7" "3" "4" "3" "471" "51.9" "5.76" "13.40" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00012" "6782" "ENSG00000155304" "HSPA13" "B2R616; hsa:6782; P48723; Q8NE40" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "1.015" "0.843" "0.978" "0.956" "0.976" "0.993" "0.953" "0.949" "0.925" "209.9" "213.0" "176.9" "205.4" "200.7" "204.9" "208.4" "200.1" "199.2" "194.2" "" "" "" "" "" "" "" "" "" "" "168.6" "153.7" "140.5" "137.6" "138.8" "153.7" "145.9" "146.1" "199.2" "157.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7633283186484640293" "False" "High" "IsMasterProtein" "Q06547" "GA-binding protein subunit beta-1 OS=Homo sapiens OX=9606 GN=GABPB1 PE=1 SV=2" "0.000" "False" "14.075" "9" "5" "7" "5" "395" "42.5" "4.86" "19.47" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "2553" "ENSG00000104064" "GABPB1" "A8IE52; hsa:2553; Q06545; Q06547; Q12940; Q12941; Q12942; Q8IYD0" "" "Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression" "3" "0" "0.954" "0.945" "1.096" "1.021" "0.952" "0.970" "1.110" "1.078" "0.992" "458.4" "437.3" "433.3" "502.3" "468.1" "436.2" "444.7" "508.8" "494.1" "454.7" "" "" "" "" "" "" "" "" "" "" "368.2" "315.5" "344.2" "336.5" "323.7" "327.3" "311.3" "371.6" "494.1" "369.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-827315428998804752" "False" "High" "IsMasterProtein" "Q9H9L4" "KAT8 regulatory NSL complex subunit 2 OS=Homo sapiens OX=9606 GN=KANSL2 PE=1 SV=3" "0.000" "False" "14.064" "7" "3" "3" "3" "492" "55.0" "6.62" "10.68" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf13891" "54934" "ENSG00000139620" "KANSL2" "hsa:54934; Q8N3B5; Q96CV0; Q9H9L4; Q9NX51" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7198883007019988074" "False" "High" "IsMasterProtein" "Cont_Q8N1N4" "Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2" "0.000" "True" "14.052" "8" "5" "5" "3" "520" "56.8" "6.02" "15.38" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "196374" "ENSG00000170423" "KRT78" "A8K4D6; hsa:196374; Q5HYM7; Q7RTT2; Q8N1N4" "Formation of the cornified envelope" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630432664316486602" "False" "High" "IsMasterProtein" "Q16563" "Synaptophysin-like protein 1 OS=Homo sapiens OX=9606 GN=SYPL1 PE=1 SV=1" "0.000" "False" "14.048" "14" "2" "4" "2" "259" "28.5" "8.43" "18.70" "2" "cell-cell signaling" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf01284" "6856" "ENSG00000008282" "SYPL1" "A4D0R2; hsa:6856; Q16563; Q96AR8" "" "" "0" "0" "1.004" "0.992" "0.865" "1.037" "1.061" "0.956" "1.077" "0.955" "0.985" "276.4" "277.5" "274.2" "239.1" "286.8" "293.3" "264.4" "297.7" "264.1" "272.2" "" "" "" "" "" "" "" "" "" "" "222.0" "200.2" "217.8" "160.2" "198.3" "220.1" "185.1" "217.4" "264.1" "221.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1727135258656817627" "False" "High" "IsMasterProtein" "Q9BTL3" "RNA guanine-N7 methyltransferase activating subunit OS=Homo sapiens OX=9606 GN=RAMAC PE=1 SV=1" "0.000" "False" "14.038" "34" "4" "5" "4" "118" "14.4" "8.94" "14.03" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15320" "83640" "ENSG00000169612" "RAMAC" "hsa:83640; Q2M1J8; Q9BTL3" "" "15q25 copy number variation" "1" "0" "0.969" "0.918" "1.027" "1.039" "0.926" "1.044" "0.983" "0.959" "0.956" "178.8" "173.3" "164.2" "183.7" "185.8" "165.6" "186.7" "175.7" "171.4" "170.9" "" "" "" "" "" "" "" "" "" "" "143.6" "125.1" "130.4" "123.1" "128.5" "124.2" "130.7" "128.3" "171.4" "139.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8334369527451810461" "False" "High" "IsMasterProtein" "Q8NF64" "Zinc finger MIZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZMIZ2 PE=1 SV=2" "0.000" "False" "14.006" "3" "3" "3" "1" "920" "96.5" "7.12" "11.73" "3" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02891" "83637" "ENSG00000122515" "ZMIZ2" "A4D2K7; D3DVL1; hsa:83637; O94790; Q0VGB4; Q659A8; Q6JKL5; Q8NF64; Q8WTX8; Q96Q01; Q9BQH7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696526329741067639" "False" "High" "IsMasterProtein" "Q14344" "Guanine nucleotide-binding protein subunit alpha-13 OS=Homo sapiens OX=9606 GN=GNA13 PE=1 SV=2" "0.000" "False" "13.994" "7" "2" "3" "1" "377" "44.0" "8.00" "3.88" "2" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "10672" "ENSG00000120063" "GNA13" "B2R977; B7Z7R0; F5H1G8; hsa:10672; Q14344; Q8TD70" "G alpha (12/13) signalling events; Thrombin signalling through proteinase activated receptors (PARs); Thromboxane signalling through TP receptor; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK" "Thyroid stimulating hormone (TSH) signaling pathway; G protein signaling pathways; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; G13 signaling pathway" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8869464350434744721" "False" "High" "IsMasterProtein" "O95372" "Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1" "0.000" "False" "13.959" "18" "4" "8" "4" "231" "24.7" "7.23" "18.48" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "11313" "ENSG00000011009" "LYPLA2" "hsa:11313; O95372; Q7Z4Z2" "L1CAM interactions" "" "1" "0" "1.046" "1.054" "1.066" "1.090" "1.019" "1.067" "1.036" "1.081" "1.056" "912.2" "953.8" "961.3" "972.8" "994.5" "929.6" "973.0" "945.4" "986.4" "963.6" "" "" "" "" "" "" "" "" "" "" "732.7" "688.2" "763.6" "651.8" "687.8" "697.4" "681.2" "690.4" "986.4" "783.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "115101743397248701" "False" "High" "IsMasterProtein" "Q15528" "Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2" "0.000" "False" "13.957" "16" "3" "6" "3" "200" "22.2" "4.68" "11.78" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06179" "6837" "ENSG00000148297; ENSG00000281022" "MED22" "B3KW83; B3KWX4; hsa:6837; O76072; Q15528; Q5T8U0" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "1.054" "1.154" "1.184" "1.021" "1.036" "1.108" "1.031" "1.122" "1.135" "269.1" "283.6" "310.7" "318.8" "274.9" "278.9" "298.2" "277.4" "301.9" "305.4" "" "" "" "" "" "" "" "" "" "" "216.2" "204.7" "246.8" "213.6" "190.1" "209.2" "208.8" "202.6" "301.9" "248.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2516739525907873838" "False" "High" "IsMasterProtein" "Q96RN5" "Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2" "0.000" "False" "13.956" "7" "4" "4" "4" "788" "86.7" "9.42" "15.06" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09606, Pf21538, Pf21539" "51586" "ENSG00000099917" "MED15" "D3DX31; D3DX32; hsa:51586; O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q96RN5; Q9P1T3" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; 22q11.2 copy number variation syndrome" "7" "0" "0.986" "1.089" "1.181" "0.858" "1.550" "0.772" "1.213" "1.115" "1.383" "13.4" "13.2" "14.6" "15.8" "11.5" "20.7" "10.3" "16.2" "14.9" "18.5" "" "" "" "" "" "" "" "" "" "" "10.7" "9.5" "11.6" "10.6" "7.9" "15.5" "7.2" "11.8" "14.9" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2300421444410781361" "False" "High" "IsMasterProtein" "Q9BRP1" "Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1" "0.000" "False" "13.948" "13" "3" "3" "3" "358" "39.4" "4.86" "9.89" "3" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf04194" "84306" "ENSG00000126249" "PDCD2L" "hsa:84306; Q9BRP1" "" "" "0" "0" "1.078" "0.999" "0.878" "1.156" "1.171" "1.041" "1.253" "1.272" "1.143" "205.2" "221.1" "204.9" "180.1" "237.2" "240.3" "213.6" "257.1" "261.0" "234.5" "" "" "" "" "" "" "" "" "" "" "164.8" "159.5" "162.8" "120.7" "164.0" "180.3" "149.6" "187.8" "261.0" "190.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8249329923731337218" "False" "High" "IsMasterProtein" "Q86U38" "Nucleolar protein 9 OS=Homo sapiens OX=9606 GN=NOP9 PE=1 SV=1" "0.000" "False" "13.922" "6" "3" "3" "3" "636" "69.4" "7.28" "10.12" "3" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "" "" "161424" "ENSG00000196943; ENSG00000285326" "NOP9" "A8MY76; hsa:161424; Q86U38; Q8IVF0; Q8TBS6" "" "" "0" "0" "1.102" "1.336" "1.424" "0.990" "1.374" "1.378" "1.180" "1.205" "1.153" "31.6" "34.8" "42.2" "45.0" "31.3" "43.4" "43.6" "37.3" "38.1" "36.5" "" "" "" "" "" "" "" "" "" "" "25.4" "25.1" "33.5" "30.2" "21.6" "32.6" "30.5" "27.3" "38.1" "29.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1438891196455375570" "False" "High" "IsMasterProtein" "A9UHW6" "MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1" "0.000" "False" "13.912" "19" "4" "6" "4" "222" "25.4" "5.33" "19.75" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854" "57409" "ENSG00000125457" "MIF4GD" "A9UHW6; B4DUM7; hsa:57409; Q8N4Q5; Q9HBL5" "" "" "0" "0" "0.881" "0.954" "0.948" "1.079" "1.024" "0.972" "1.098" "1.092" "1.033" "827.0" "728.2" "788.6" "783.8" "892.5" "846.7" "803.7" "907.8" "903.5" "854.3" "" "" "" "" "" "" "" "" "" "" "664.3" "525.5" "626.4" "525.1" "617.2" "635.3" "562.7" "663.0" "903.5" "694.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6779909124529057950" "False" "High" "IsMasterProtein" "Q16773" "Kynurenine--oxoglutarate transaminase 1 OS=Homo sapiens OX=9606 GN=KYAT1 PE=1 SV=1" "0.000" "False" "13.909" "8" "3" "6" "2" "422" "47.8" "6.47" "18.12" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00155" "883" "ENSG00000171097" "KYAT1" "hsa:883; Q16773; Q5T275; Q8N191" "Tryptophan catabolism; Glutamate and glutamine metabolism; Phenylalanine metabolism" "" "3" "0" "0.992" "0.915" "1.046" "1.015" "0.899" "0.964" "0.870" "0.911" "0.957" "187.1" "185.6" "171.3" "195.7" "189.8" "168.2" "180.5" "162.8" "170.4" "179.0" "" "" "" "" "" "" "" "" "" "" "150.3" "133.9" "136.1" "131.1" "131.3" "126.2" "126.3" "118.9" "170.4" "145.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "717271239892975644" "False" "High" "IsMasterProtein" "Q9UK73" "Protein fem-1 homolog B OS=Homo sapiens OX=9606 GN=FEM1B PE=1 SV=1" "0.000" "False" "13.891" "8" "4" "4" "4" "627" "70.2" "6.61" "8.65" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf12796" "10116" "ENSG00000169018" "FEM1B" "hsa:10116; O43146; Q9UK73" "Neddylation" "" "1" "0" "1.125" "1.036" "1.040" "1.084" "1.087" "1.076" "1.094" "1.098" "1.096" "189.1" "212.6" "195.9" "196.7" "204.9" "205.5" "203.5" "206.9" "207.6" "207.2" "" "" "" "" "" "" "" "" "" "" "151.9" "153.4" "155.6" "131.8" "141.7" "154.2" "142.5" "151.1" "207.6" "168.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4927987348987010712" "False" "High" "IsMasterProtein" "P35790" "Choline kinase alpha OS=Homo sapiens OX=9606 GN=CHKA PE=1 SV=3" "0.000" "False" "13.884" "11" "4" "4" "4" "457" "52.2" "6.55" "16.03" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1119" "ENSG00000110721" "CHKA" "hsa:1119; P35790; Q8NE29" "Synthesis of PC; Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Acetylcholine synthesis" "6" "0" "1.041" "1.009" "1.033" "1.014" "0.931" "1.005" "0.987" "1.058" "0.980" "383.4" "399.0" "386.8" "396.2" "388.9" "357.2" "385.3" "378.3" "405.7" "375.8" "" "" "" "" "" "" "" "" "" "" "308.0" "287.9" "307.2" "265.4" "269.0" "268.0" "269.8" "276.3" "405.7" "305.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3974339187776743055" "False" "High" "IsMasterProtein" "Q93074" "Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4" "0.000" "False" "13.863" "2" "5" "5" "5" "2177" "242.9" "7.05" "13.94" "5" "cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09497, Pf12144, Pf12145" "9968" "ENSG00000184634" "MED12" "hsa:9968; O15410; O75557; Q93074; Q9UHV6; Q9UND7" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "0.945" "1.028" "1.124" "1.144" "1.103" "1.181" "1.448" "1.099" "1.135" "199.8" "188.7" "205.3" "224.5" "228.5" "220.4" "236.0" "289.3" "219.5" "226.7" "" "" "" "" "" "" "" "" "" "" "160.5" "136.2" "163.1" "150.4" "158.0" "165.3" "165.2" "211.3" "219.5" "184.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836769617334137947" "False" "High" "IsMasterProtein" "Q96LA8" "Protein arginine N-methyltransferase 6 OS=Homo sapiens OX=9606 GN=PRMT6 PE=1 SV=1" "0.000" "False" "13.849" "10" "3" "3" "3" "375" "41.9" "5.44" "10.32" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf13649" "55170" "ENSG00000198890" "PRMT6" "A3KME1; B4DID8; hsa:55170; Q5T5Y5; Q6DKI4; Q96LA8; Q9NVR8" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines" "Male infertility; Nitric oxide metabolism in cystic fibrosis" "4" "0" "1.171" "1.134" "1.356" "1.352" "1.409" "1.339" "1.158" "1.234" "1.331" "218.8" "256.1" "248.1" "296.6" "295.7" "308.3" "293.0" "253.3" "269.9" "291.2" "" "" "" "" "" "" "" "" "" "" "175.7" "184.8" "197.1" "198.7" "204.5" "231.3" "205.1" "185.0" "269.9" "236.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6957065747657519198" "False" "High" "IsMasterProtein" "P33552" "Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1" "0.000" "False" "13.844" "33" "3" "10" "2" "79" "9.9" "8.46" "28.16" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1164" "ENSG00000123975" "CKS2" "hsa:1164; P33552; Q6FGI9; Q6LET5" "" "Small cell lung cancer" "1" "0" "1.033" "0.988" "1.081" "1.025" "1.040" "0.932" "0.830" "0.905" "1.039" "273.3" "282.4" "270.1" "295.4" "280.1" "284.2" "254.6" "226.8" "247.2" "283.9" "" "" "" "" "" "" "" "" "" "" "219.5" "203.8" "214.5" "197.9" "193.7" "213.3" "178.3" "165.6" "247.2" "230.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3476524128370901588" "False" "High" "IsMasterProtein" "P53634" "Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2" "0.000" "False" "13.837" "6" "2" "2" "2" "463" "51.8" "6.99" "9.14" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08773" "1075" "ENSG00000109861" "CTSC" "A8K7V2; B5MDD5; hsa:1075; P53634; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8" "MHC class II antigen presentation; Neutrophil degranulation; COPII-mediated vesicle transport; Cargo concentration in the ER" "" "4" "0" "0.964" "0.921" "0.915" "1.087" "0.980" "0.943" "0.938" "0.965" "1.002" "291.3" "280.9" "268.4" "266.7" "316.7" "285.6" "274.6" "273.3" "281.2" "292.0" "" "" "" "" "" "" "" "" "" "" "234.0" "202.7" "213.2" "178.7" "219.1" "214.2" "192.3" "199.6" "281.2" "237.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818998789770137613" "False" "High" "IsMasterProtein" "Q9Y4W6" "Mitochondrial inner membrane m-AAA protease component AFG3L2 OS=Homo sapiens OX=9606 GN=AFG3L2 PE=1 SV=2" "0.000" "False" "13.831" "5" "3" "3" "3" "797" "88.5" "8.66" "10.93" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00004, Pf01434, Pf06480, Pf17862" "10939" "ENSG00000141385" "AFG3L2" "hsa:10939; Q6P1L0; Q9Y4W6" "Mitochondrial protein degradation; Processing of SMDT1" "Ciliary landscape; 10q22q23 copy number variation" "4" "0" "0.797" "0.918" "0.950" "0.992" "1.046" "0.812" "0.755" "0.851" "0.765" "46.6" "37.2" "42.8" "44.3" "46.3" "48.8" "37.9" "35.2" "39.7" "35.7" "" "" "" "" "" "" "" "" "" "" "37.5" "26.8" "34.0" "29.7" "32.0" "36.6" "26.5" "25.7" "39.7" "29.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "765579875042607640" "False" "High" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "0.000" "False" "13.828" "32" "3" "8" "2" "81" "9.1" "8.43" "23.39" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "TGF-beta receptor signaling activates SMADs; UCH proteinases; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Iron uptake and transport" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "7" "0" "1.038" "1.056" "1.016" "0.889" "0.940" "0.964" "0.945" "0.924" "0.845" "1105.0" "1147.3" "1166.5" "1122.7" "982.5" "1038.2" "1064.7" "1043.9" "1021.4" "933.2" "" "" "" "" "" "" "" "" "" "" "887.5" "827.9" "926.6" "752.2" "679.5" "778.9" "745.5" "762.3" "1021.4" "758.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9028825818345530826" "False" "High" "IsMasterProtein" "Q9UNZ5" "Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19orf53 PE=1 SV=1" "0.000" "False" "13.822" "40" "5" "9" "5" "99" "10.6" "11.55" "25.84" "5" "" "" "" "Pf09495" "28974" "ENSG00000104979" "C19orf53" "B2R4J9; hsa:28974; Q9UNZ5" "" "" "0" "0" "1.049" "1.069" "1.024" "1.004" "1.036" "1.036" "0.971" "0.962" "1.032" "679.9" "712.9" "727.0" "696.4" "682.3" "704.5" "704.7" "660.1" "653.7" "701.9" "" "" "" "" "" "" "" "" "" "" "546.1" "514.4" "577.4" "466.6" "471.9" "528.6" "493.4" "482.1" "653.7" "570.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6504309841328491303" "False" "High" "IsMasterProtein" "Q8NAF0" "Zinc finger protein 579 OS=Homo sapiens OX=9606 GN=ZNF579 PE=1 SV=2" "0.000" "False" "13.821" "3" "1" "1" "1" "562" "60.5" "8.69" "6.59" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "163033" "ENSG00000218891" "ZNF579" "hsa:163033; Q8NAF0" "" "" "0" "0" "1.221" "1.200" "1.080" "1.090" "1.102" "0.881" "1.080" "1.131" "1.172" "106.5" "130.0" "127.8" "115.0" "116.1" "117.3" "93.8" "115.0" "120.4" "124.8" "" "" "" "" "" "" "" "" "" "" "85.5" "93.8" "101.5" "77.0" "80.3" "88.0" "65.7" "84.0" "120.4" "101.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485483695822680049" "False" "High" "IsMasterProtein" "Q9Y5R8" "Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1" "0.000" "False" "13.795" "32" "4" "5" "4" "145" "16.8" "9.16" "14.50" "4" "cell organization and biogenesis;transport" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "58485" "ENSG00000170043" "TRAPPC1" "D3DTR0; hsa:58485; Q9Y5R8" "COPII-mediated vesicle transport; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs" "" "3" "0" "0.987" "0.990" "1.040" "1.045" "0.977" "1.097" "0.969" "0.977" "0.991" "265.7" "262.3" "263.0" "276.3" "277.7" "259.6" "291.6" "257.5" "259.7" "263.3" "" "" "" "" "" "" "" "" "" "" "213.4" "189.3" "208.9" "185.1" "192.1" "194.8" "204.1" "188.1" "259.7" "214.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-727224885467951098" "False" "High" "IsMasterProtein" "O75925" "E3 SUMO-protein ligase PIAS1 OS=Homo sapiens OX=9606 GN=PIAS1 PE=1 SV=2" "0.000" "False" "13.791" "6" "2" "2" "1" "651" "71.8" "7.30" "8.12" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02891, Pf14324" "8554" "ENSG00000033800" "PIAS1" "B2RB67; B3KSY9; C5J4B4; hsa:8554; O75925; Q147X4; Q99751; Q9UN02" "SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER" "Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways" "14" "0" "0.863" "0.711" "0.768" "0.789" "0.735" "0.933" "0.603" "0.612" "0.731" "20.8" "17.9" "14.7" "15.9" "16.4" "15.2" "19.4" "12.5" "12.7" "15.2" "" "" "" "" "" "" "" "" "" "" "16.7" "12.9" "11.7" "10.7" "11.3" "11.4" "13.6" "9.1" "12.7" "12.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4662290285667358635" "False" "High" "IsMasterProtein" "P34947" "G protein-coupled receptor kinase 5 OS=Homo sapiens OX=9606 GN=GRK5 PE=1 SV=1" "0.000" "False" "13.781" "4" "2" "3" "1" "590" "67.7" "8.10" "10.71" "2" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00615" "2869" "ENSG00000198873" "GRK5" "D3DRD0; hsa:2869; P34947; Q5T059" "G alpha (q) signalling events; G alpha (s) signalling events" "Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Comprehensive IL-17A signaling; Calcium regulation in cardiac cells" "6" "0" "0.943" "0.997" "0.971" "0.888" "0.908" "1.125" "0.978" "0.944" "0.965" "193.8" "182.8" "193.3" "188.3" "172.1" "176.1" "218.1" "189.5" "183.0" "187.0" "" "" "" "" "" "" "" "" "" "" "155.7" "131.9" "153.5" "126.1" "119.1" "132.1" "152.7" "138.4" "183.0" "152.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1694253408134936187" "False" "High" "IsMasterProtein" "P50452" "Serpin B8 OS=Homo sapiens OX=9606 GN=SERPINB8 PE=1 SV=2" "0.000" "False" "13.780" "11" "3" "3" "1" "374" "42.7" "5.57" "5.62" "3" "cell adhesion;other biological processes" "non-structural extracellular;cytosol;other cell component" "enzyme regulator activity" "Pf00079" "5271" "ENSG00000166401" "SERPINB8" "B4DTW2; P50452; Q7Z2V6; Q8N178" "Dissolution of Fibrin Clot" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3776455647046576995" "False" "High" "IsMasterProtein" "Q7L3B6" "Hsp90 co-chaperone Cdc37-like 1 OS=Homo sapiens OX=9606 GN=CDC37L1 PE=1 SV=1" "0.000" "False" "13.775" "13" "4" "5" "4" "337" "38.8" "5.34" "10.08" "4" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf08565" "55664" "ENSG00000106993" "CDC37L1" "B1AL70; hsa:55664; Q7L3B6; Q9NWS3; Q9NX16" "Platelet degranulation" "" "1" "0" "0.907" "0.957" "0.968" "0.957" "0.861" "0.877" "0.979" "0.930" "0.882" "133.1" "120.7" "127.4" "128.9" "127.5" "114.6" "116.8" "130.3" "123.8" "117.5" "" "" "" "" "" "" "" "" "" "" "106.9" "87.1" "101.2" "86.4" "88.2" "86.0" "81.7" "95.2" "123.8" "95.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8312057505130700222" "False" "High" "IsMasterProtein" "P06865" "Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2" "0.000" "False" "13.761" "7" "4" "5" "4" "529" "60.7" "5.16" "14.97" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3073" "ENSG00000213614" "HEXA" "B4DKE7; E7ENH7; hsa:3073; P06865; Q53HS8; Q6AI32" "CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXA causes GM2G1" "Degradation pathway of sphingolipids, including diseases; Glycosaminoglycan degradation" "7" "0" "1.021" "0.960" "1.024" "1.149" "1.187" "1.134" "1.267" "1.029" "1.264" "63.1" "64.4" "60.5" "64.6" "72.5" "74.8" "71.5" "79.9" "64.9" "79.7" "" "" "" "" "" "" "" "" "" "" "50.6" "46.4" "48.1" "43.3" "50.1" "56.1" "50.1" "58.3" "64.9" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5894079024390586831" "False" "High" "IsMasterProtein" "Q9NQ29" "Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1" "0.000" "False" "13.754" "19" "7" "8" "3" "371" "43.7" "9.92" "17.28" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "55692" "ENSG00000007392" "LUC7L" "B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.987" "1.008" "1.091" "1.004" "1.058" "1.113" "1.169" "1.092" "1.108" "325.2" "321.0" "327.7" "354.8" "326.4" "344.1" "362.0" "380.1" "355.1" "360.2" "" "" "" "" "" "" "" "" "" "" "261.2" "231.6" "260.3" "237.7" "225.8" "258.2" "253.4" "277.6" "355.1" "292.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4718319405373936898" "False" "High" "IsMasterProtein" "Q5TA45" "Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2" "0.000" "False" "13.746" "6" "4" "4" "4" "600" "67.6" "8.06" "14.86" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07521, Pf10996, Pf16661, Pf21386" "54973" "ENSG00000127054" "INTS11" "A8K5S2; B3KPR3; B4DM87; G3V1S5; hsa:54973; Q5TA45; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.075" "1.018" "0.974" "1.021" "0.989" "0.990" "0.943" "0.963" "0.975" "587.0" "631.3" "597.9" "571.9" "599.3" "580.6" "581.2" "553.3" "565.2" "572.4" "" "" "" "" "" "" "" "" "" "" "471.5" "455.5" "474.9" "383.2" "414.5" "435.6" "406.9" "404.1" "565.2" "465.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1094871198918048732" "False" "High" "IsMasterProtein" "O00287" "Regulatory factor X-associated protein OS=Homo sapiens OX=9606 GN=RFXAP PE=1 SV=1" "0.000" "False" "13.733" "8" "2" "3" "2" "272" "28.2" "5.54" "9.35" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf15289" "5994" "ENSG00000133111" "RFXAP" "B2R9T8; hsa:5994; O00287; Q5VZM6; Q8TC40" "" "" "0" "0" "1.179" "1.245" "1.327" "1.307" "1.106" "1.323" "1.135" "1.115" "1.084" "81.4" "95.9" "101.3" "108.0" "106.4" "90.0" "107.7" "92.3" "90.7" "88.2" "" "" "" "" "" "" "" "" "" "" "65.3" "69.2" "80.5" "72.3" "73.6" "67.5" "75.4" "67.4" "90.7" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2809025675902823137" "False" "High" "IsMasterProtein" "Q9H2Y7" "Zinc finger protein 106 OS=Homo sapiens OX=9606 GN=ZNF106 PE=1 SV=1" "0.000" "False" "13.729" "2" "3" "3" "3" "1883" "208.8" "7.15" "9.32" "3" "signal transduction" "other membranes;cytosol;nucleus" "other molecular function" "Pf00400" "64397" "ENSG00000103994" "ZNF106" "B4DZ40; E9PE29; hsa:64397; Q6NSD9; Q6PEK1; Q86T43; Q86T45; Q86T50; Q86T58; Q86TA9; Q96M37; Q9H2Y7; Q9H7B8" "" "" "0" "0" "0.918" "0.939" "1.028" "1.029" "1.061" "0.992" "1.043" "0.989" "0.998" "339.9" "311.9" "319.1" "349.5" "349.9" "360.7" "337.0" "354.6" "336.1" "339.3" "" "" "" "" "" "" "" "" "" "" "273.0" "225.0" "253.5" "234.2" "242.0" "270.6" "236.0" "258.9" "336.1" "275.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8236633477379487928" "False" "High" "IsMasterProtein" "Q9UPZ3" "BLOC-2 complex member HPS5 OS=Homo sapiens OX=9606 GN=HPS5 PE=1 SV=2" "0.000" "False" "13.725" "2" "2" "4" "2" "1129" "127.4" "5.54" "9.43" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "" "" "11234" "ENSG00000110756; ENSG00000288445" "HPS5" "A8K6J8; A8K8S1; D3DQX9; D3DQY0; hsa:11234; O95942; Q8N4U0; Q9UPZ3" "" "" "0" "0" "1.533" "0.949" "1.127" "0.858" "0.886" "1.394" "1.008" "1.099" "1.174" "25.2" "38.6" "23.9" "28.4" "21.6" "22.3" "35.1" "25.3" "27.7" "29.5" "" "" "" "" "" "" "" "" "" "" "20.2" "27.8" "19.0" "19.0" "14.9" "16.7" "24.6" "18.5" "27.7" "24.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6933895130976224833" "False" "High" "IsMasterProtein" "P23511" "Nuclear transcription factor Y subunit alpha OS=Homo sapiens OX=9606 GN=NFYA PE=1 SV=2" "0.000" "False" "13.697" "12" "2" "6" "2" "347" "36.9" "8.94" "18.66" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02045" "4800" "ENSG00000001167" "NFYA" "hsa:4800; P23511; Q8IXU0" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways" "8" "0" "1.137" "1.035" "1.100" "1.103" "1.000" "1.020" "0.989" "1.025" "1.245" "147.0" "167.1" "152.2" "161.7" "162.2" "147.0" "149.9" "145.3" "150.6" "183.1" "" "" "" "" "" "" "" "" "" "" "118.1" "120.6" "120.9" "108.3" "112.2" "110.3" "104.9" "106.1" "150.6" "148.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6705073720058711891" "False" "High" "IsMasterProtein" "Q96BP2" "Small ribosomal subunit protein mS37 OS=Homo sapiens OX=9606 GN=CHCHD1 PE=1 SV=1" "0.000" "False" "13.694" "23" "2" "2" "2" "118" "13.5" "10.21" "8.33" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "" "Pf06747" "118487" "ENSG00000172586" "CHCHD1" "hsa:118487; Q96BP2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6636555355274069790" "False" "High" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "0.000" "False" "13.672" "31" "3" "4" "3" "83" "9.3" "5.12" "14.17" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "Mitochondrial protein import" "" "1" "0" "1.039" "1.006" "1.021" "0.882" "0.922" "0.942" "0.910" "0.896" "0.915" "775.8" "805.9" "780.1" "792.2" "684.1" "714.9" "730.4" "705.8" "695.5" "709.5" "" "" "" "" "" "" "" "" "" "" "623.1" "581.5" "619.6" "530.7" "473.2" "536.4" "511.4" "515.4" "695.5" "577.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266136317046350400" "False" "High" "IsMasterProtein" "Q70Z53" "Protein FRA10AC1 OS=Homo sapiens OX=9606 GN=FRA10AC1 PE=1 SV=3" "0.000" "False" "13.652" "13" "5" "7" "5" "315" "37.5" "8.10" "19.04" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf09725" "118924" "ENSG00000148690" "FRA10AC1" "C9JCR4; C9JCR5; C9JMY4; hsa:118924; Q70Z49; Q70Z50; Q70Z51; Q70Z52; Q70Z53; Q8N293; Q8WVH5; Q96JQ8" "" "" "0" "0" "0.980" "0.964" "0.983" "0.869" "0.908" "0.875" "0.856" "0.912" "0.936" "456.2" "446.9" "439.5" "448.4" "396.4" "414.1" "398.9" "390.4" "416.1" "427.0" "" "" "" "" "" "" "" "" "" "" "366.4" "322.5" "349.1" "300.4" "274.1" "310.7" "279.3" "285.1" "416.1" "347.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6342489706270133022" "False" "High" "IsMasterProtein" "O43933" "Peroxisomal ATPase PEX1 OS=Homo sapiens OX=9606 GN=PEX1 PE=1 SV=1" "0.000" "False" "13.648" "3" "4" "4" "4" "1283" "142.8" "6.33" "9.71" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00004, Pf09262, Pf09263, Pf17862" "5189" "ENSG00000127980" "PEX1" "A4D1G3; A8KA90; B4DIM7; E9PE75; hsa:5189; O43933; Q96S71; Q96S72; Q96S73; Q99994" "Peroxisomal protein import" "" "1" "0" "1.182" "1.065" "1.036" "1.158" "1.060" "1.019" "1.099" "1.135" "1.201" "103.4" "122.2" "110.1" "107.2" "119.7" "109.6" "105.4" "113.6" "117.4" "124.3" "" "" "" "" "" "" "" "" "" "" "83.1" "88.2" "87.5" "71.8" "82.8" "82.3" "73.8" "83.0" "117.4" "101.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6354795615061229423" "False" "High" "IsMasterProtein" "O14862" "Interferon-inducible protein AIM2 OS=Homo sapiens OX=9606 GN=AIM2 PE=1 SV=1" "0.000" "False" "13.637" "9" "3" "3" "3" "343" "38.9" "9.79" "9.96" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "9447" "ENSG00000163568" "AIM2" "A8K7M7; O14862; Q5T3V9; Q96FG9" "Cytosolic sensors of pathogen-associated DNA ; The AIM2 inflammasome" "Nucleotide-binding oligomerization domain (NOD) pathway; Cytosolic DNA-sensing pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8229141518412539790" "False" "High" "IsMasterProtein" "P68036" "Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1" "0.000" "False" "13.615" "16" "3" "9" "3" "154" "17.9" "8.51" "25.63" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7332" "ENSG00000185651" "UBE2L3" "B2R4A7; B4DDG1; B4DSZ4; E7EWS7; hsa:7332; P51966; P68036; P70653; Q9HAV1" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of necroptotic cell death; Regulation of TNFR1 signaling" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "7" "0" "1.027" "1.008" "1.026" "0.979" "0.942" "1.005" "1.026" "0.983" "0.973" "1090.6" "1120.4" "1099.6" "1118.5" "1067.5" "1027.0" "1096.6" "1118.6" "1072.2" "1061.4" "" "" "" "" "" "" "" "" "" "" "876.0" "808.5" "873.4" "749.4" "738.3" "770.5" "767.8" "816.9" "1072.2" "863.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3530209516211162637" "False" "High" "IsMasterProtein" "Q5JRA6" "Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1" "0.000" "False" "13.608" "2" "3" "3" "3" "1907" "213.6" "4.84" "9.77" "3" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07653" "375056" "ENSG00000154305" "MIA3" "A8K2S0; A8MT05; A8MT13; B7Z430; hsa:375056; Q14083; Q3S4X3; Q5JRA5; Q5JRA6; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; Q86Y60; Q8N8M5; Q92580" "Cargo concentration in the ER; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Type I collagen synthesis in the context of osteogenesis imperfecta" "4" "0" "1.268" "1.510" "1.396" "1.369" "1.275" "1.269" "1.471" "1.274" "1.383" "59.9" "76.0" "90.5" "83.6" "82.0" "76.4" "76.0" "88.2" "76.4" "82.9" "" "" "" "" "" "" "" "" "" "" "48.1" "54.8" "71.9" "56.0" "56.7" "57.3" "53.2" "64.4" "76.4" "67.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853605967738796226" "False" "High" "IsMasterProtein" "Q13137" "Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1" "0.000" "False" "13.558" "9" "4" "4" "4" "446" "52.2" "5.02" "11.89" "4" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17751" "10241" "ENSG00000136436" "CALCOCO2" "B2RBT0; B4DDC4; B4DDT4; B4DP36; B4E0C0; E7ENK0; E7ETP5; E9PBE5; hsa:10241; Q13137; Q53FQ5; Q53HB5; Q6IBN9; Q9BTF7" "" "" "0" "0" "0.966" "0.924" "0.947" "0.991" "0.990" "1.038" "0.965" "0.976" "1.004" "426.1" "411.8" "393.7" "403.6" "422.2" "422.0" "442.1" "411.3" "416.0" "427.6" "" "" "" "" "" "" "" "" "" "" "342.3" "297.1" "312.7" "270.4" "292.0" "316.6" "309.5" "300.4" "416.0" "347.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3133890418348041849" "False" "High" "IsMasterProtein" "Q5T6F0" "DDB1- and CUL4-associated factor 12 OS=Homo sapiens OX=9606 GN=DCAF12 PE=1 SV=1" "0.000" "False" "13.553" "9" "4" "4" "4" "453" "50.5" "9.10" "12.59" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "25853" "ENSG00000198876" "DCAF12" "A8KA70; D3DRL6; hsa:25853; Q5T6E9; Q5T6F0; Q5T6F1; Q6P3V0; Q7L4F8; Q96PZ5; Q9NXA9; Q9UFJ1" "" "" "0" "0" "0.857" "1.031" "0.994" "0.991" "1.014" "0.954" "0.876" "0.910" "0.947" "347.1" "297.4" "357.8" "344.9" "343.9" "352.0" "331.2" "304.2" "315.8" "328.7" "" "" "" "" "" "" "" "" "" "" "278.8" "214.6" "284.2" "231.1" "237.8" "264.1" "231.9" "222.2" "315.8" "267.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812205563963537221" "False" "High" "IsMasterProtein" "Q9BSH5" "Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1" "0.000" "False" "13.532" "13" "3" "4" "3" "251" "28.0" "6.71" "14.79" "3" "" "nucleus;other cell component" "" "Pf00702" "81932" "ENSG00000119431" "HDHD3" "B2RD47; hsa:81932; Q9BSH5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4465081379876381336" "False" "High" "IsMasterProtein" "Q86U70" "LIM domain-binding protein 1 OS=Homo sapiens OX=9606 GN=LDB1 PE=1 SV=2" "0.000" "False" "13.522" "19" "6" "6" "6" "411" "46.5" "6.96" "9.94" "6" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01803, Pf17916" "8861" "ENSG00000198728" "LDB1" "B4DUC4; hsa:8861; O75479; O96010; Q1EQX1; Q86U70; Q9UGM4" "Regulation of expression of SLITs and ROBOs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Expression and translocation of olfactory receptors; Cardiogenesis" "" "4" "0" "0.960" "0.911" "0.969" "1.019" "1.002" "0.915" "0.995" "1.000" "1.032" "427.2" "410.0" "389.2" "413.9" "435.4" "428.1" "391.0" "425.3" "427.0" "441.0" "" "" "" "" "" "" "" "" "" "" "343.1" "295.8" "309.1" "277.3" "301.1" "321.2" "273.8" "310.6" "427.0" "358.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3724111757375065163" "False" "High" "IsMasterProtein" "Q9P0W2" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related OS=Homo sapiens OX=9606 GN=HMG20B PE=1 SV=1" "0.000" "False" "13.511" "7" "2" "2" "2" "317" "35.8" "9.35" "9.00" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "10362" "ENSG00000064961" "HMG20B" "A6NMS5; D6W616; hsa:10362; Q6IBP8; Q8NBD5; Q9HD21; Q9P0W2; Q9Y491; Q9Y4A2" "Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS; HDACs deacetylate histones" "" "3" "0" "1.113" "1.047" "1.024" "1.052" "0.980" "0.995" "1.034" "1.039" "1.050" "389.6" "433.7" "407.9" "398.8" "409.8" "381.8" "387.5" "402.7" "404.7" "409.0" "" "" "" "" "" "" "" "" "" "" "312.9" "312.9" "324.0" "267.2" "283.4" "286.5" "271.3" "294.1" "404.7" "332.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2518500882063606702" "False" "High" "IsMasterProtein" "Q13164" "Mitogen-activated protein kinase 7 OS=Homo sapiens OX=9606 GN=MAPK7 PE=1 SV=2" "0.000" "False" "13.510" "3" "2" "2" "2" "816" "88.3" "5.88" "8.59" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5598" "ENSG00000166484" "MAPK7" "hsa:5598; Q13164; Q16634; Q59F50; Q6QLU7; Q7L4P4; Q969G1; Q96G51" "Senescence-Associated Secretory Phenotype (SASP); RET signaling; Gastrin-CREB signalling pathway via PKC and MAPK; ERKs are inactivated; Signalling to ERK5" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; S1P receptor signal transduction; Cardiac hypertrophic response; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Pleural mesothelioma; GDNF signaling" "20" "0" "1.124" "1.032" "1.036" "1.186" "1.011" "1.087" "1.162" "1.142" "1.034" "154.2" "173.3" "159.1" "159.7" "182.9" "155.8" "167.6" "179.2" "176.0" "159.4" "" "" "" "" "" "" "" "" "" "" "123.8" "125.0" "126.4" "107.0" "126.5" "116.9" "117.4" "130.9" "176.0" "129.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566707279340017586" "False" "High" "IsMasterProtein" "Q9Y6M7" "Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2" "0.000" "False" "13.504" "4" "5" "5" "5" "1214" "136.0" "6.71" "12.80" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "9497" "ENSG00000033867" "SLC4A7" "A6NIA8; B2CI53; B5M449; B5M451; B5M452; B5M453; B6DY52; B6DY53; C9JST9; D3K174; D3K175; hsa:9497; O60350; Q6AHZ9; Q9HC88; Q9UIB9; Q9Y6M7" "RHOJ GTPase cycle; RHOQ GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; RHOH GTPase cycle; Bicarbonate transporters" "IL-18 signaling pathway" "7" "0" "0.925" "0.922" "0.995" "1.058" "0.986" "1.224" "1.105" "1.176" "1.009" "144.6" "133.8" "133.3" "143.8" "153.0" "142.6" "177.0" "159.8" "170.0" "145.9" "" "" "" "" "" "" "" "" "" "" "116.1" "96.5" "105.9" "96.4" "105.8" "107.0" "123.9" "116.7" "170.0" "118.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8434101151437963191" "False" "High" "IsMasterProtein" "Q7Z2K8" "G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2" "0.000" "False" "13.487" "6" "5" "5" "5" "1008" "102.3" "8.06" "12.27" "5" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf15235" "114787" "ENSG00000169258" "GPRIN1" "C9JM70; hsa:114787; Q7Z2K8; Q8ND74; Q96PZ4" "MECP2 regulates neuronal receptors and channels" "MECP2 and associated Rett syndrome; 5q35 copy number variation" "3" "0" "0.856" "0.954" "1.176" "1.050" "0.843" "0.941" "1.142" "1.037" "0.949" "146.5" "125.4" "139.7" "172.2" "153.8" "123.6" "137.8" "167.2" "152.0" "138.9" "" "" "" "" "" "" "" "" "" "" "117.6" "90.5" "111.0" "115.4" "106.4" "92.7" "96.5" "122.1" "152.0" "113.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2596521025155403540" "False" "High" "IsMasterProtein" "Q9BXM9" "FSD1-like protein OS=Homo sapiens OX=9606 GN=FSD1L PE=1 SV=2" "0.000" "False" "13.484" "9" "3" "3" "3" "530" "59.5" "6.20" "9.92" "3" "" "" "" "Pf00622" "83856" "ENSG00000106701" "FSD1L" "A2A338; A6NKH7; B7Z5S6; B7Z5W3; hsa:83856; Q5T879; Q5T880; Q9BXM9" "" "" "0" "0" "0.820" "0.993" "1.011" "0.775" "1.102" "0.930" "0.896" "0.988" "0.937" "59.0" "48.4" "58.7" "59.7" "45.8" "65.1" "54.9" "52.9" "58.4" "55.4" "" "" "" "" "" "" "" "" "" "" "47.4" "35.0" "46.6" "40.0" "31.6" "48.8" "38.5" "38.6" "58.4" "45.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687201697740038391" "False" "High" "IsMasterProtein" "Q9NP92" "Large ribosomal subunit protein mL65 OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" "0.000" "False" "13.476" "8" "3" "4" "3" "439" "50.3" "7.97" "15.10" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "10884" "ENSG00000112996" "MRPS30" "hsa:10884; Q96I91; Q96Q19; Q9H0P8; Q9NP92; Q9NSF9; Q9NZ76" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.952" "1.027" "1.085" "1.002" "0.955" "0.953" "0.975" "0.978" "1.011" "475.1" "452.3" "487.9" "515.6" "476.2" "453.5" "452.6" "463.4" "464.8" "480.1" "" "" "" "" "" "" "" "" "" "" "381.6" "326.4" "387.5" "345.4" "329.3" "340.2" "316.9" "338.4" "464.8" "390.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9216293239382485608" "False" "High" "IsMasterProtein" "Q96TA2" "ATP-dependent zinc metalloprotease YME1L1 OS=Homo sapiens OX=9606 GN=YME1L1 PE=1 SV=2" "0.000" "False" "13.474" "4" "2" "2" "2" "773" "86.4" "8.76" "6.55" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00004, Pf01434, Pf17862" "10730" "ENSG00000136758" "YME1L1" "B4DNM1; D3DRV8; D3DRV9; Q5T8D9; Q96TA2; Q9H1Q0; Q9UMR9" "Mitochondrial protein degradation; Processing of SMDT1; Cellular response to mitochondrial stress" "" "3" "0" "1.402" "0.958" "1.284" "0.981" "0.980" "1.181" "1.054" "0.938" "0.995" "144.6" "202.7" "138.5" "185.6" "141.8" "141.7" "170.7" "152.4" "135.6" "143.9" "" "" "" "" "" "" "" "" "" "" "116.1" "146.2" "110.0" "124.4" "98.1" "106.3" "119.5" "111.3" "135.6" "117.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3065352799485715425" "False" "High" "IsMasterProtein" "Q9P0P0" "E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1" "0.000" "False" "13.471" "31" "5" "7" "5" "153" "17.9" "5.06" "18.60" "5" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "51255" "ENSG00000168894" "RNF181" "hsa:51255; Q53H81; Q9P0P0" "E3 ubiquitin ligases ubiquitinate target proteins" "" "1" "0" "1.086" "1.019" "1.132" "0.967" "0.988" "1.067" "0.988" "0.934" "1.019" "644.8" "700.1" "657.3" "730.2" "623.8" "637.2" "687.9" "637.3" "602.0" "657.4" "" "" "" "" "" "" "" "" "" "" "517.9" "505.2" "522.1" "489.2" "431.4" "478.0" "481.6" "465.4" "602.0" "534.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2213528751694895262" "False" "High" "IsMasterProtein" "Q8N2W9" "E3 SUMO-protein ligase PIAS4 OS=Homo sapiens OX=9606 GN=PIAS4 PE=1 SV=1" "0.000" "False" "13.468" "6" "3" "4" "3" "510" "56.5" "6.14" "12.22" "3" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02891, Pf14324" "51588" "ENSG00000105229" "PIAS4" "O75926; Q8N2W9; Q96G19; Q9UN16" "SUMOylation of intracellular receptors; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; SUMOylation of immune response proteins" "Androgen receptor signaling pathway" "14" "0" "1.016" "0.981" "1.027" "1.088" "1.055" "1.016" "1.086" "1.058" "1.096" "305.6" "310.6" "299.7" "313.7" "332.4" "322.4" "310.6" "331.9" "323.2" "334.9" "" "" "" "" "" "" "" "" "" "" "245.4" "224.1" "238.0" "210.2" "229.9" "241.9" "217.5" "242.4" "323.2" "272.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564485370032939878" "False" "High" "IsMasterProtein" "Q9UBV8" "Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1" "0.000" "False" "13.464" "14" "4" "6" "4" "284" "30.4" "6.54" "15.40" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf13405, Pf13499" "553115" "ENSG00000162517" "PEF1" "hsa:553115; Q9UBV8" "" "" "0" "0" "1.088" "1.070" "1.167" "1.074" "1.127" "1.104" "1.071" "1.083" "1.068" "679.5" "739.6" "726.8" "793.0" "729.9" "765.8" "750.1" "727.9" "735.9" "725.8" "" "" "" "" "" "" "" "" "" "" "545.7" "533.6" "577.3" "531.3" "504.8" "574.6" "525.2" "531.6" "735.9" "590.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359859415185382416" "False" "High" "IsMasterProtein" "O75575" "DNA-directed RNA polymerase III subunit RPC9 OS=Homo sapiens OX=9606 GN=CRCP PE=1 SV=1" "0.000" "False" "13.450" "26" "3" "3" "3" "148" "16.9" "5.39" "8.96" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03874" "27297" "ENSG00000241258" "CRCP" "A8MUZ4; A8MW23; B2R4H4; B4E198; hsa:27297; O75575; Q3KRA3; Q5HYF1; Q8IXL4" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Myometrial relaxation and contraction pathways" "8" "0" "0.900" "1.118" "1.070" "0.889" "0.942" "0.982" "1.291" "0.880" "1.172" "31.2" "28.1" "34.9" "33.4" "27.8" "29.4" "30.7" "40.3" "27.5" "36.6" "" "" "" "" "" "" "" "" "" "" "25.1" "20.3" "27.7" "22.4" "19.2" "22.1" "21.5" "29.4" "27.5" "29.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697914900789617779" "False" "High" "IsMasterProtein" "Q7RTV0" "PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1" "0.000" "False" "13.433" "26" "3" "4" "3" "110" "12.4" "8.41" "15.76" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03660" "84844" "ENSG00000100410" "PHF5A" "hsa:84844; Q7RTV0; Q9UH06" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.025" "1.000" "0.783" "0.905" "1.085" "0.888" "0.918" "0.991" "0.943" "552.1" "565.9" "552.0" "432.2" "499.9" "599.1" "490.5" "506.9" "547.2" "520.8" "" "" "" "" "" "" "" "" "" "" "443.5" "408.4" "438.5" "289.6" "345.7" "449.5" "343.4" "370.2" "547.2" "423.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5390707735378390925" "False" "High" "IsMasterProtein" "Q8IYB3" "Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2" "0.000" "False" "13.375" "4" "3" "3" "3" "904" "102.3" "11.84" "10.59" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf01480" "10250" "ENSG00000133226" "SRRM1" "hsa:10250; O60585; Q5VVN4; Q8IYB3" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "7" "0" "0.788" "0.877" "1.083" "1.009" "1.136" "1.576" "1.227" "1.072" "1.067" "135.6" "106.8" "118.9" "146.8" "136.8" "154.1" "213.7" "166.4" "145.4" "144.7" "" "" "" "" "" "" "" "" "" "" "108.9" "77.1" "94.5" "98.4" "94.6" "115.6" "149.6" "121.6" "145.4" "117.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2415988570574177896" "False" "High" "IsMasterProtein" "P13196" "5-aminolevulinate synthase, non-specific, mitochondrial OS=Homo sapiens OX=9606 GN=ALAS1 PE=1 SV=2" "0.000" "False" "13.330" "9" "6" "6" "6" "640" "70.5" "8.46" "10.40" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00155, Pf09029" "211" "ENSG00000023330" "ALAS1" "hsa:211; P13196" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; PPARA activates gene expression; Heme biosynthesis" "Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "8" "0" "0.907" "0.992" "1.055" "1.053" "0.982" "1.032" "1.017" "1.043" "1.057" "210.6" "191.1" "209.0" "222.1" "221.7" "206.9" "217.3" "214.1" "219.8" "222.6" "" "" "" "" "" "" "" "" "" "" "169.1" "137.9" "166.0" "148.8" "153.3" "155.2" "152.1" "156.4" "219.8" "181.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4539117867176903484" "False" "High" "IsMasterProtein" "P50402" "Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1" "0.000" "False" "13.306" "13" "3" "3" "3" "254" "29.0" "5.50" "11.87" "3" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf03020" "2010" "ENSG00000102119" "EMD" "hsa:2010; P50402; Q6FI02" "Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling" "12" "0" "1.063" "0.898" "1.139" "1.110" "1.163" "1.267" "1.294" "1.161" "1.163" "201.4" "214.1" "180.8" "229.5" "223.6" "234.3" "255.1" "260.6" "233.9" "234.3" "" "" "" "" "" "" "" "" "" "" "161.8" "154.5" "143.6" "153.8" "154.6" "175.8" "178.6" "190.3" "233.9" "190.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703372283530206058" "False" "High" "IsMasterProtein" "Q9NP97" "Dynein light chain roadblock-type 1 OS=Homo sapiens OX=9606 GN=DYNLRB1 PE=1 SV=3" "0.000" "False" "13.305" "23" "2" "3" "2" "96" "10.9" "7.25" "10.01" "2" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83658" "ENSG00000125971" "DYNLRB1" "B1AKR5; hsa:83658; Q5TC72; Q96IV3; Q9NP97; Q9NQM2" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "4" "0" "1.179" "1.089" "1.092" "0.950" "1.101" "1.143" "0.979" "1.006" "1.037" "60.3" "71.1" "65.7" "65.9" "57.3" "66.4" "69.0" "59.1" "60.7" "62.5" "" "" "" "" "" "" "" "" "" "" "48.5" "51.3" "52.2" "44.2" "39.6" "49.8" "48.3" "43.2" "60.7" "50.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845069297566421061" "False" "High" "IsMasterProtein" "P35221" "Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1" "0.000" "False" "13.300" "4" "3" "3" "3" "906" "100.0" "6.29" "11.05" "3" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "1495" "ENSG00000044115" "CTNNA1" "hsa:1495; P35221; Q12795; Q8N1C0" "RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "15" "0" "1.068" "0.973" "1.252" "0.963" "0.886" "1.240" "1.196" "1.162" "1.101" "96.4" "103.0" "93.8" "120.6" "92.8" "85.4" "119.5" "115.3" "112.0" "106.1" "" "" "" "" "" "" "" "" "" "" "77.4" "74.3" "74.5" "80.8" "64.2" "64.1" "83.7" "84.2" "112.0" "86.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824788000835968644" "False" "High" "IsMasterProtein" "O15182" "Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2" "0.000" "False" "13.298" "27" "5" "6" "4" "167" "19.5" "4.74" "15.50" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1070" "ENSG00000153140" "CETN3" "hsa:1070; O15182; Q53YD2; Q9BS23" "" "Breast cancer pathway" "1" "0" "1.005" "1.019" "1.121" "1.091" "1.072" "0.948" "1.066" "1.066" "1.135" "402.9" "404.9" "410.4" "451.8" "439.4" "431.9" "382.1" "429.4" "429.6" "457.3" "" "" "" "" "" "" "" "" "" "" "323.6" "292.2" "326.0" "302.7" "303.9" "324.0" "267.5" "313.6" "429.6" "371.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6683808966160304215" "False" "High" "IsMasterProtein" "P78560" "Death domain-containing protein CRADD OS=Homo sapiens OX=9606 GN=CRADD PE=1 SV=1" "0.000" "False" "13.284" "25" "4" "7" "4" "199" "22.7" "6.80" "20.05" "4" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00531, Pf00619" "8738" "ENSG00000169372" "CRADD" "B7Z2Q5; hsa:8738; P78560" "TP53 Regulates Transcription of Caspase Activators and Caspases" "Apoptosis" "2" "0" "0.981" "0.931" "1.024" "0.940" "0.960" "0.995" "0.996" "0.854" "0.959" "297.7" "292.1" "277.2" "305.0" "279.8" "285.7" "296.3" "296.5" "254.2" "285.6" "" "" "" "" "" "" "" "" "" "" "239.1" "210.8" "220.2" "204.4" "193.5" "214.4" "207.4" "216.6" "254.2" "232.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6553541234872075133" "False" "High" "IsMasterProtein" "Q8N488" "RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2" "0.000" "False" "13.276" "14" "3" "3" "2" "228" "24.8" "9.63" "11.35" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "23429" "ENSG00000163602; ENSG00000281766" "RYBP" "hsa:23429; Q8N488; Q9P2W5; Q9UMW4" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "" "2" "1" "0.994" "0.876" "0.985" "0.948" "0.994" "0.980" "0.998" "1.079" "1.013" "314.1" "312.1" "275.2" "309.6" "297.7" "312.4" "308.0" "313.4" "338.9" "318.1" "" "" "" "" "" "" "" "" "" "" "252.3" "225.2" "218.6" "207.4" "205.9" "234.4" "215.6" "228.9" "338.9" "258.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2963381124708492524" "False" "High" "IsMasterProtein" "Q5JTH9" "RRP12-like protein OS=Homo sapiens OX=9606 GN=RRP12 PE=1 SV=2" "0.000" "False" "13.250" "3" "3" "3" "3" "1297" "143.6" "8.75" "9.49" "3" "RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf08161" "23223" "ENSG00000052749" "RRP12" "B4DK00; E9PCK7; hsa:23223; Q5JTH8; Q5JTH9; Q69YK4; Q96E87; Q9BUH3; Q9Y4C7" "" "" "0" "0" "1.136" "1.117" "1.207" "1.056" "1.104" "1.028" "1.168" "1.178" "1.131" "189.5" "215.3" "211.6" "228.7" "200.1" "209.1" "194.7" "221.2" "223.1" "214.2" "" "" "" "" "" "" "" "" "" "" "152.2" "155.4" "168.1" "153.2" "138.4" "156.9" "136.3" "161.5" "223.1" "174.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4972524321603701932" "False" "High" "IsMasterProtein" "Q8IW35" "Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1" "0.000" "False" "13.249" "4" "3" "3" "3" "865" "96.9" "5.02" "10.37" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14580" "79598" "ENSG00000182504" "CEP97" "B5MDY8; hsa:79598; Q8IW35; Q8NA71; Q9H5T9" "Anchoring of the basal body to the plasma membrane; RHOV GTPase cycle" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome" "5" "0" "0.973" "0.966" "1.018" "0.978" "0.993" "0.996" "1.042" "1.109" "1.111" "233.6" "227.2" "225.7" "237.9" "228.5" "232.0" "232.6" "243.4" "259.1" "259.4" "" "" "" "" "" "" "" "" "" "" "187.6" "164.0" "179.3" "159.4" "158.0" "174.1" "162.8" "177.8" "259.1" "211.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4959898328745925415" "False" "High" "IsMasterProtein" "Q6IN84" "rRNA methyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=MRM1 PE=1 SV=1" "0.000" "False" "13.239" "13" "3" "3" "3" "353" "38.6" "7.94" "9.34" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588, Pf08032" "79922" "ENSG00000274853; ENSG00000278619" "MRM1" "A8K8E2; hsa:79922; Q6IN84; Q96GK2; Q9H664" "rRNA modification in the mitochondrion" "17q12 copy number variation syndrome" "2" "0" "0.999" "0.930" "1.025" "1.119" "1.135" "1.041" "1.253" "0.847" "1.078" "58.0" "58.0" "53.9" "59.5" "65.0" "65.9" "60.4" "72.7" "49.2" "62.6" "" "" "" "" "" "" "" "" "" "" "46.6" "41.8" "42.9" "39.8" "44.9" "49.4" "42.3" "53.1" "49.2" "50.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062599375234318027" "False" "High" "IsMasterProtein" "Q02447" "Transcription factor Sp3 OS=Homo sapiens OX=9606 GN=SP3 PE=1 SV=3" "0.000" "False" "13.223" "6" "3" "4" "3" "781" "81.9" "5.26" "15.11" "3" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6670" "ENSG00000172845" "SP3" "A0AVL9; B4E2B7; hsa:6670; Q02447; Q69B26; Q69B27; Q8TD56; Q8WWU4; Q9BQR1" "SUMOylation of transcription factors" "Selenium metabolism and selenoproteins; MECP2 and associated Rett syndrome; Non-genomic actions of 1,25 dihydroxyvitamin D3; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "1.001" "1.005" "0.975" "0.978" "1.001" "0.877" "0.945" "0.967" "1.092" "344.6" "345.1" "346.3" "335.9" "337.0" "345.1" "302.2" "325.6" "333.3" "376.3" "" "" "" "" "" "" "" "" "" "" "276.8" "249.0" "275.1" "225.1" "233.1" "258.9" "211.6" "237.8" "333.3" "306.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4353457585173966729" "False" "High" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "0.000" "False" "13.222" "41" "4" "8" "4" "59" "6.9" "10.45" "27.83" "4" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "1.043" "1.015" "1.117" "1.192" "1.077" "1.177" "1.119" "1.126" "1.093" "690.6" "720.2" "701.2" "771.5" "823.4" "743.7" "813.0" "772.9" "777.9" "755.1" "" "" "" "" "" "" "" "" "" "" "554.7" "519.7" "557.0" "516.9" "569.5" "558.0" "569.2" "564.5" "777.9" "614.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4561933771637395336" "False" "High" "IsMasterProtein" "Q15329" "Transcription factor E2F5 OS=Homo sapiens OX=9606 GN=E2F5 PE=1 SV=1" "0.000" "False" "13.209" "12" "4" "4" "2" "346" "37.6" "5.10" "13.25" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1875" "ENSG00000133740" "E2F5" "E9PBN9; hsa:1875; Q15329; Q16601; Q92756" "G1/S-Specific Transcription; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Cyclin D associated events in G1; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Spinal cord injury; Pre-implantation embryo; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6950247271112546932" "False" "High" "IsMasterProtein" "Q9H3N1" "Thioredoxin-related transmembrane protein 1 OS=Homo sapiens OX=9606 GN=TMX1 PE=1 SV=1" "0.000" "False" "13.199" "8" "1" "1" "1" "280" "31.8" "4.98" "7.22" "1" "stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085" "81542" "ENSG00000139921" "TMX1" "B2R7A4; hsa:81542; Q8N487; Q8NBN5; Q9H3N1; Q9Y4T6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7482733620363159602" "False" "High" "IsMasterProtein" "Q9BVS5" "tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2" "0.000" "False" "13.190" "6" "3" "5" "3" "477" "52.9" "6.62" "11.97" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf08704" "55006" "ENSG00000171103" "TRMT61B" "hsa:55006; Q9BVS5; Q9H0Q9; Q9NWS7" "tRNA modification in the mitochondrion" "" "1" "0" "0.934" "0.850" "1.216" "0.988" "0.746" "0.971" "1.015" "0.959" "0.881" "59.4" "55.5" "50.5" "72.3" "58.7" "44.3" "57.7" "60.3" "57.0" "52.3" "" "" "" "" "" "" "" "" "" "" "47.7" "40.0" "40.1" "48.4" "40.6" "33.2" "40.4" "44.0" "57.0" "42.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-768881656379736442" "False" "High" "IsMasterProtein" "Q9BT73" "Proteasome assembly chaperone 3 OS=Homo sapiens OX=9606 GN=PSMG3 PE=1 SV=1" "0.000" "False" "13.166" "23" "2" "3" "2" "122" "13.1" "7.88" "13.77" "2" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf10178" "84262" "ENSG00000157778" "PSMG3" "A4D216; A8MPW2; hsa:84262; Q9BT73" "" "" "0" "0" "1.017" "0.963" "1.218" "1.152" "1.053" "1.127" "0.958" "1.005" "1.064" "156.7" "159.4" "150.9" "190.9" "180.6" "165.0" "176.6" "150.1" "157.5" "166.8" "" "" "" "" "" "" "" "" "" "" "125.9" "115.0" "119.8" "127.9" "124.9" "123.8" "123.7" "109.6" "157.5" "135.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-201446485204969397" "False" "High" "IsMasterProtein" "P56282" "DNA polymerase epsilon subunit 2 OS=Homo sapiens OX=9606 GN=POLE2 PE=1 SV=2" "0.000" "False" "13.155" "7" "4" "4" "3" "527" "59.5" "6.35" "11.85" "4" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04042, Pf12213" "5427" "ENSG00000100479" "POLE2" "A0AV55; A4FU92; A4LBB7; A6NH58; B4DDE6; O43560; P56282" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Activation of the pre-replicative complex; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "19" "0" "0.976" "1.094" "1.104" "0.971" "1.098" "1.042" "0.997" "0.988" "1.102" "124.2" "121.2" "135.9" "137.1" "120.6" "136.3" "129.4" "123.8" "122.7" "136.8" "" "" "" "" "" "" "" "" "" "" "99.7" "87.4" "108.0" "91.9" "83.4" "102.3" "90.6" "90.4" "122.7" "111.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7104112355135180301" "False" "High" "IsMasterProtein" "Q9UL26" "Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2" "0.000" "False" "13.155" "16" "3" "3" "3" "194" "21.8" "8.15" "11.29" "3" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57403" "ENSG00000124209" "RAB22A" "B3KR86; E1P605; hsa:57403; Q8TF12; Q9H4E6; Q9UL26" "RAB geranylgeranylation" "" "1" "0" "0.982" "1.130" "0.994" "1.084" "1.120" "0.925" "1.060" "0.962" "1.035" "131.1" "128.7" "148.2" "130.3" "142.1" "146.9" "121.3" "139.0" "126.2" "135.8" "" "" "" "" "" "" "" "" "" "" "105.3" "92.9" "117.7" "87.3" "98.3" "110.2" "84.9" "101.5" "126.2" "110.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622690060897357887" "False" "High" "IsMasterProtein" "Q9UII2" "ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1" "0.000" "False" "13.143" "25" "5" "7" "5" "106" "12.2" "9.35" "20.72" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf04568" "93974" "ENSG00000130770; ENSG00000285390" "ATP5IF1" "hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2" "" "Electron transport chain: OXPHOS system in mitochondria" "1" "0" "1.004" "0.973" "0.995" "1.024" "0.970" "0.973" "1.027" "1.013" "1.006" "1031.6" "1035.8" "1004.0" "1026.0" "1056.6" "1001.1" "1004.0" "1059.2" "1045.4" "1037.8" "" "" "" "" "" "" "" "" "" "" "828.6" "747.4" "797.5" "687.5" "730.8" "751.1" "702.9" "773.5" "1045.4" "843.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3431457210334272148" "False" "High" "IsMasterProtein" "Q75QN2" "Integrator complex subunit 8 OS=Homo sapiens OX=9606 GN=INTS8 PE=1 SV=1" "0.000" "False" "13.114" "3" "2" "2" "2" "995" "113.0" "7.05" "9.98" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "" "55656" "ENSG00000164941" "INTS8" "B2RN92; hsa:55656; Q5RKZ3; Q6P1R5; Q75QN2; Q7Z314; Q9NVS6; Q9NWY7" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.052" "0.849" "1.110" "1.082" "1.015" "1.094" "1.137" "1.047" "1.070" "88.9" "93.5" "75.5" "98.7" "96.1" "90.2" "97.2" "101.1" "93.1" "95.1" "" "" "" "" "" "" "" "" "" "" "71.4" "67.4" "60.0" "66.1" "66.5" "67.7" "68.1" "73.8" "93.1" "77.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115257495252240726" "False" "High" "IsMasterProtein" "P82909" "Alpha-ketoglutarate dehydrogenase component 4 OS=Homo sapiens OX=9606 GN=KGD4 PE=1 SV=2" "0.000" "False" "13.107" "27" "2" "6" "2" "103" "11.5" "9.99" "20.17" "2" "other metabolic processes" "other membranes;mitochondrion" "" "" "92259" "ENSG00000134056; ENSG00000278461" "KGD4" "hsa:92259; P82909; Q9H2H4" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.073" "0.985" "1.131" "1.104" "1.051" "1.061" "1.018" "0.980" "0.985" "441.8" "474.1" "435.3" "499.6" "487.7" "464.1" "468.5" "449.9" "432.9" "435.2" "" "" "" "" "" "" "" "" "" "" "354.8" "342.1" "345.8" "334.8" "337.3" "348.2" "328.0" "328.6" "432.9" "353.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1155650016836113983" "False" "High" "IsMasterProtein" "Q6NYC1" "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Homo sapiens OX=9606 GN=JMJD6 PE=1 SV=1" "0.000" "False" "13.104" "7" "3" "4" "3" "403" "46.4" "8.69" "12.63" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "23210" "ENSG00000070495" "JMJD6" "B3KMN8; B4DGX1; hsa:23210; Q6NYC1; Q86VY0; Q8IUM5; Q9Y4E2" "Protein hydroxylation; HDMs demethylate histones" "" "2" "0" "1.066" "1.036" "1.045" "1.057" "1.034" "1.041" "0.990" "1.003" "1.063" "692.2" "737.6" "717.1" "723.4" "731.5" "716.0" "720.4" "685.4" "694.5" "736.0" "" "" "" "" "" "" "" "" "" "" "556.0" "532.3" "569.6" "484.7" "505.9" "537.2" "504.4" "500.6" "694.5" "598.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2039087024744643374" "False" "High" "IsMasterProtein" "Cont_Q5D862" "Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1" "0.000" "True" "13.102" "4" "3" "3" "3" "2391" "247.9" "8.31" "5.20" "3" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other cell component" "other molecular function" "Pf01023" "388698" "ENSG00000143520" "FLG2" "hsa:388698; Q5D862; Q9H4U1" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2147212707680779052" "False" "High" "IsMasterProtein" "P49427" "Ubiquitin-conjugating enzyme E2 R1 OS=Homo sapiens OX=9606 GN=CDC34 PE=1 SV=2" "0.000" "False" "13.079" "16" "5" "6" "4" "236" "26.7" "4.54" "15.36" "5" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "997" "ENSG00000099804" "CDC34" "A8K689; hsa:997; P49427" "FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Vitamin D receptor pathway" "6" "0" "1.127" "1.119" "1.003" "0.999" "1.175" "0.967" "1.046" "1.090" "1.183" "187.3" "211.2" "209.7" "187.8" "187.1" "220.2" "181.1" "196.0" "204.1" "221.6" "" "" "" "" "" "" "" "" "" "" "150.5" "152.4" "166.6" "125.8" "129.4" "165.2" "126.8" "143.1" "204.1" "180.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1435707363815542229" "False" "High" "IsMasterProtein" "Q9ULG1" "Chromatin-remodeling ATPase INO80 OS=Homo sapiens OX=9606 GN=INO80 PE=1 SV=2" "0.000" "False" "13.063" "2" "3" "3" "3" "1556" "176.6" "9.50" "10.21" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf13892" "54617" "ENSG00000128908" "INO80" "A6H8X4; hsa:54617; Q9NTG6; Q9ULG1" "DNA Damage Recognition in GG-NER; UCH proteinases" "" "2" "0" "0.984" "1.012" "1.020" "0.893" "0.961" "0.900" "1.045" "0.830" "0.905" "76.9" "75.7" "77.8" "78.5" "68.7" "73.9" "69.2" "80.4" "63.8" "69.6" "" "" "" "" "" "" "" "" "" "" "61.8" "54.6" "61.8" "52.6" "47.5" "55.4" "48.5" "58.7" "63.8" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4012099030302879857" "False" "High" "IsMasterProtein" "P49137" "MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1" "0.000" "False" "13.054" "9" "4" "8" "1" "400" "45.5" "8.68" "21.79" "4" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9261" "ENSG00000162889" "MAPKAPK2" "hsa:9261; P49137; Q5SY30; Q5SY41; Q8IYD6" "Oxidative Stress Induced Senescence; VEGFA-VEGFR2 Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TNFR1 signaling; p38MAPK events; activated TAK1 mediates p38 MAPK activation; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Pleural mesothelioma; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "21" "0" "0.955" "0.957" "1.048" "1.021" "0.948" "0.898" "0.924" "1.014" "1.081" "167.2" "159.7" "160.1" "175.2" "170.8" "158.4" "150.1" "154.4" "169.6" "180.7" "" "" "" "" "" "" "" "" "" "" "134.3" "115.2" "127.1" "117.4" "118.1" "118.9" "105.1" "112.8" "169.6" "146.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235528814650407609" "False" "High" "IsMasterProtein" "Q96DT6" "Cysteine protease ATG4C OS=Homo sapiens OX=9606 GN=ATG4C PE=1 SV=1" "0.000" "False" "13.050" "11" "4" "5" "4" "458" "52.5" "5.97" "9.96" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other cell component" "other molecular function" "Pf03416, Pf20166" "84938" "ENSG00000125703" "ATG4C" "A6NLR8; D3DQ58; hsa:84938; Q96DT6; Q96K04" "Macroautophagy" "Clock-controlled autophagy in bone metabolism" "2" "0" "1.089" "1.004" "1.052" "0.970" "1.073" "0.827" "0.947" "0.978" "1.227" "159.2" "173.4" "159.8" "167.5" "154.4" "170.8" "131.6" "150.7" "155.7" "195.3" "" "" "" "" "" "" "" "" "" "" "127.8" "125.1" "126.9" "112.2" "106.8" "128.2" "92.2" "110.0" "155.7" "158.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8490030146092636123" "False" "High" "IsMasterProtein" "Q7Z422" "SUZ RNA-binding domain-containing OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1" "0.000" "False" "13.050" "20" "2" "3" "2" "152" "17.0" "8.95" "13.70" "2" "" "" "" "Pf12752, Pf12901" "26099" "ENSG00000055070; ENSG00000291379" "SZRD1" "A8MXJ2; C9K0U0; hsa:26099; Q7Z422; Q7Z424; Q8IVM2; Q8TBV3; Q9Y403" "" "" "0" "0" "0.991" "0.951" "1.136" "0.918" "0.941" "1.237" "0.932" "0.932" "1.071" "279.7" "277.4" "266.0" "317.8" "256.9" "263.2" "345.9" "260.8" "260.8" "299.6" "" "" "" "" "" "" "" "" "" "" "224.7" "200.1" "211.3" "213.0" "177.7" "197.5" "242.2" "190.5" "260.8" "243.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8473772251373638669" "False" "High" "IsMasterProtein" "Q12907" "Vesicular integral-membrane protein VIP36 OS=Homo sapiens OX=9606 GN=LMAN2 PE=1 SV=1" "0.000" "False" "13.043" "8" "3" "3" "3" "356" "40.2" "6.95" "9.45" "3" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03388" "10960" "ENSG00000169223" "LMAN2" "hsa:10960; Q12907; Q53HH1" "COPII-mediated vesicle transport; Cargo concentration in the ER" "5q35 copy number variation" "3" "0" "1.027" "0.879" "1.064" "0.945" "0.968" "0.945" "0.790" "0.798" "0.955" "234.9" "241.2" "206.5" "249.8" "221.9" "227.4" "221.9" "185.6" "187.5" "224.2" "" "" "" "" "" "" "" "" "" "" "188.6" "174.1" "164.0" "167.4" "153.5" "170.6" "155.4" "135.6" "187.5" "182.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8700335326144916466" "False" "High" "IsMasterProtein" "Q9UET6" "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "0.000" "False" "13.034" "13" "3" "3" "3" "329" "36.1" "5.69" "10.47" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.974" "0.995" "0.869" "0.955" "0.953" "0.852" "0.913" "1.013" "0.965" "187.1" "182.3" "186.3" "162.6" "178.8" "178.4" "159.5" "170.8" "189.6" "180.6" "" "" "" "" "" "" "" "" "" "" "150.3" "131.5" "148.0" "108.9" "123.7" "133.9" "111.6" "124.8" "189.6" "146.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246938043361698856" "False" "High" "IsMasterProtein" "O94842" "TOX high mobility group box family member 4 OS=Homo sapiens OX=9606 GN=TOX4 PE=1 SV=1" "0.000" "False" "13.030" "4" "1" "2" "1" "621" "66.2" "5.06" "12.42" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "9878" "ENSG00000092203" "TOX4" "B4DPY8; B4DSM0; E7EV69; hsa:9878; O94842" "" "" "0" "0" "0.988" "1.189" "1.030" "0.883" "0.723" "0.750" "0.844" "0.844" "1.034" "76.5" "75.5" "90.9" "78.8" "67.5" "55.3" "57.4" "64.6" "64.6" "79.1" "" "" "" "" "" "" "" "" "" "" "61.4" "54.5" "72.2" "52.8" "46.7" "41.5" "40.2" "47.1" "64.6" "64.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7698628990297234698" "False" "High" "IsMasterProtein" "Q9Y3D3" "Small ribosomal subunit protein bS16m OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" "0.000" "False" "13.021" "31" "4" "5" "4" "137" "15.3" "9.50" "17.02" "4" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00886" "51021" "ENSG00000182180" "MRPS16" "B4E032; hsa:51021; Q96Q60; Q9Y3D3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.003" "0.992" "0.920" "0.858" "0.938" "0.805" "1.009" "0.880" "0.905" "462.7" "464.2" "459.0" "425.6" "396.8" "434.0" "372.7" "466.8" "407.3" "418.6" "" "" "" "" "" "" "" "" "" "" "371.7" "334.9" "364.6" "285.1" "274.4" "325.6" "261.0" "340.9" "407.3" "340.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2343192111564668879" "False" "High" "IsMasterProtein" "Q96NW4" "Ankyrin repeat domain-containing protein 27 OS=Homo sapiens OX=9606 GN=ANKRD27 PE=1 SV=2" "0.000" "False" "13.015" "3" "3" "3" "3" "1050" "116.9" "6.87" "11.72" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02204, Pf12796" "84079" "ENSG00000105186" "ANKRD27" "hsa:84079; Q71MF5; Q86UC3; Q8ND80; Q96NW4; Q9H0I4" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.041" "1.019" "1.169" "1.098" "1.024" "1.015" "1.096" "1.132" "1.197" "366.3" "381.4" "373.2" "428.3" "402.2" "375.2" "371.9" "401.4" "414.6" "438.7" "" "" "" "" "" "" "" "" "" "" "294.2" "275.2" "296.4" "287.0" "278.2" "281.5" "260.4" "293.2" "414.6" "356.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5468986810261152963" "False" "High" "IsMasterProtein" "Q15334" "Lethal(2) giant larvae protein homolog 1 OS=Homo sapiens OX=9606 GN=LLGL1 PE=1 SV=3" "0.000" "False" "13.014" "3" "3" "3" "3" "1064" "115.3" "6.29" "10.26" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf08366" "3996" "ENSG00000131899" "LLGL1" "A7MBM7; hsa:3996; O00188; Q15334; Q58F11; Q86UK6" "" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "1" "0" "0.732" "1.017" "1.199" "1.121" "1.003" "1.371" "1.348" "1.022" "1.226" "43.9" "32.1" "44.7" "52.7" "49.2" "44.0" "60.2" "59.2" "44.9" "53.8" "" "" "" "" "" "" "" "" "" "" "35.3" "23.2" "35.5" "35.3" "34.1" "33.0" "42.2" "43.2" "44.9" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-981252296573627161" "False" "High" "IsMasterProtein" "Q8NCN4" "E3 ubiquitin-protein ligase RNF169 OS=Homo sapiens OX=9606 GN=RNF169 PE=1 SV=2" "0.000" "False" "13.008" "6" "4" "5" "4" "708" "77.1" "9.10" "12.97" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13920" "254225" "ENSG00000166439" "RNF169" "hsa:254225; Q6N015; Q8NCN4" "" "" "0" "0" "1.046" "1.124" "1.127" "1.184" "0.977" "1.143" "1.118" "1.068" "1.082" "123.2" "128.9" "138.5" "138.8" "145.8" "120.3" "140.8" "137.6" "131.6" "133.3" "" "" "" "" "" "" "" "" "" "" "98.9" "93.0" "110.0" "93.0" "100.9" "90.3" "98.6" "100.5" "131.6" "108.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4077783620514139312" "False" "High" "IsMasterProtein" "Q15650" "Activating signal cointegrator 1 OS=Homo sapiens OX=9606 GN=TRIP4 PE=1 SV=4" "0.000" "False" "13.005" "7" "4" "4" "4" "581" "66.1" "7.85" "11.41" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04266, Pf06221" "9325" "ENSG00000103671" "TRIP4" "B2RAS0; hsa:9325; Q15650; Q96ED7; Q9UKH0" "" "VEGFA-VEGFR2 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5364683920046459506" "False" "High" "IsMasterProtein" "O75340" "Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1" "0.000" "False" "12.982" "16" "3" "4" "3" "191" "21.9" "5.40" "14.22" "3" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13499" "10016" "ENSG00000249915" "PDCD6" "B2RD16; E7ESR3; hsa:10016; O75340; Q2YDC2; Q5TZS0" "" "Epithelial to mesenchymal transition in colorectal cancer" "1" "0" "1.019" "1.057" "1.029" "1.048" "1.204" "1.087" "1.012" "0.983" "1.121" "412.8" "420.7" "436.4" "424.8" "432.5" "497.0" "448.5" "417.9" "405.9" "462.7" "" "" "" "" "" "" "" "" "" "" "331.5" "303.5" "346.6" "284.6" "299.1" "372.9" "314.0" "305.2" "405.9" "376.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766767178054047588" "False" "High" "IsMasterProtein" "Q9BYC9" "Large ribosomal subunit protein bL20m OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" "0.000" "False" "12.977" "23" "4" "4" "4" "149" "17.4" "10.86" "12.47" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00453" "55052" "ENSG00000242485" "MRPL20" "B2RE41; B7Z746; hsa:55052; Q9BYC9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "1p36 copy number variation syndrome" "4" "0" "1.015" "0.778" "1.011" "0.823" "0.994" "0.793" "0.966" "0.839" "0.937" "107.1" "108.7" "83.3" "108.3" "88.2" "106.5" "85.0" "103.4" "89.8" "100.3" "" "" "" "" "" "" "" "" "" "" "86.0" "78.4" "66.2" "72.6" "61.0" "79.9" "59.5" "75.5" "89.8" "81.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2849777412656735708" "False" "High" "IsMasterProtein" "Q13190" "Syntaxin-5 OS=Homo sapiens OX=9606 GN=STX5 PE=1 SV=2" "0.000" "False" "12.974" "7" "2" "2" "2" "355" "39.6" "9.16" "8.73" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf05739, Pf11416" "6811" "ENSG00000162236" "STX5" "B2R8T2; F8W8Q9; hsa:6811; Q13190; Q5U0D4; Q7Z3T6; Q9BUG1" "RHOA GTPase cycle; COPI-mediated anterograde transport; RHOC GTPase cycle; RHOG GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Intra-Golgi traffic; COPII-mediated vesicle transport; Cargo concentration in the ER" "Alstrom syndrome" "9" "0" "1.143" "0.997" "1.163" "1.135" "0.998" "1.040" "1.241" "1.083" "1.008" "97.3" "111.2" "97.0" "113.1" "110.4" "97.1" "101.3" "120.8" "105.4" "98.1" "" "" "" "" "" "" "" "" "" "" "78.2" "80.2" "77.0" "75.8" "76.4" "72.8" "70.9" "88.2" "105.4" "79.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431440183355440202" "False" "High" "IsMasterProtein" "Q9ULL5" "Proline-rich protein 12 OS=Homo sapiens OX=9606 GN=PRR12 PE=1 SV=3" "0.000" "False" "12.937" "3" "4" "4" "4" "2036" "210.9" "7.87" "11.68" "4" "" "nucleus;other cell component" "" "Pf13926" "57479" "ENSG00000126464" "PRR12" "E9PB06; hsa:57479; Q8N4J6; Q9ULL5" "" "" "0" "0" "1.007" "0.917" "1.120" "1.079" "0.947" "0.966" "0.962" "1.015" "1.073" "94.4" "95.0" "86.5" "105.7" "101.8" "89.4" "91.2" "90.8" "95.8" "101.2" "" "" "" "" "" "" "" "" "" "" "75.8" "68.6" "68.7" "70.8" "70.4" "67.1" "63.8" "66.3" "95.8" "82.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2460427567323238742" "False" "High" "IsMasterProtein" "P05771" "Protein kinase C beta type OS=Homo sapiens OX=9606 GN=PRKCB PE=1 SV=4" "0.000" "False" "12.934" "6" "4" "5" "1" "671" "76.8" "7.01" "15.09" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00168, Pf00433" "5579" "ENSG00000166501" "PRKCB" "C5IFJ8; D3DWF5; hsa:5579; O43744; P05127; P05771; Q15138; Q93060; Q9UE49; Q9UE50; Q9UEH8; Q9UJ30; Q9UJ33" "Activation of NF-kappaB in B cells; G alpha (z) signalling events; Disinhibition of SNARE formation; WNT5A-dependent internalization of FZD4; VEGFR2 mediated cell proliferation; Trafficking of GluR2-containing AMPA receptors; Depolymerization of the Nuclear Lamina; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RHO GTPases Activate NADPH Oxidases" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Serotonin and anxiety-related events; Serotonin and anxiety; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; Ras signaling; Non-small cell lung cancer; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Orexin receptor pathway; Chronic hyperglycemia impairment of neuron function; Macrophage-stimulating protein (MSP) signaling network map; Calcium regulation in cardiac cells; ErbB signaling pathway" "48" "0" "1.145" "1.250" "1.310" "1.278" "1.403" "1.228" "1.197" "1.378" "1.314" "136.8" "156.6" "171.0" "179.2" "174.8" "191.9" "168.0" "163.7" "188.6" "179.8" "" "" "" "" "" "" "" "" "" "" "109.9" "113.0" "135.8" "120.1" "120.9" "144.0" "117.7" "119.5" "188.6" "146.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7618289525843205014" "False" "High" "IsMasterProtein" "Q7L8W6" "Diphthine--ammonia ligase OS=Homo sapiens OX=9606 GN=DPH6 PE=1 SV=3" "0.000" "False" "12.932" "12" "3" "3" "3" "267" "30.3" "5.40" "9.78" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01902" "89978" "ENSG00000134146" "DPH6" "B3KWG1; hsa:89978; Q7L8W6; Q96HJ6" "Synthesis of diphthamide-EEF2" "" "1" "0" "1.038" "0.924" "1.111" "1.118" "1.038" "1.044" "1.104" "1.181" "0.998" "41.1" "42.7" "38.0" "45.7" "46.0" "42.7" "42.9" "45.4" "48.6" "41.1" "" "" "" "" "" "" "" "" "" "" "33.0" "30.8" "30.2" "30.6" "31.8" "32.0" "30.1" "33.2" "48.6" "33.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5727120310183573784" "False" "High" "IsMasterProtein" "Q92560" "Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2" "0.000" "False" "12.921" "6" "4" "5" "4" "729" "80.3" "6.84" "15.57" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01088, Pf18031" "8314" "ENSG00000163930" "BAP1" "A8K993; hsa:8314; Q6LEM0; Q7Z5E8; Q92560" "UCH proteinases; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "Clear cell renal cell carcinoma pathways; Pleural mesothelioma; Kleefstra syndrome" "5" "0" "1.051" "1.026" "1.002" "1.035" "1.049" "1.055" "1.032" "1.096" "1.108" "358.3" "376.6" "367.5" "358.8" "370.8" "376.0" "378.1" "369.7" "392.7" "396.9" "" "" "" "" "" "" "" "" "" "" "287.8" "271.8" "291.9" "240.4" "256.5" "282.1" "264.7" "270.0" "392.7" "322.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621637110793391590" "False" "High" "IsMasterProtein" "Q9BV79" "Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2" "0.000" "False" "12.908" "8" "3" "4" "3" "373" "40.4" "8.76" "13.00" "3" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00107, Pf08240" "51102" "ENSG00000116353" "MECR" "B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9BV79; Q9Y373" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" "Fatty acid biosynthesis; Mitochondrial fatty acid synthesis pathway" "3" "0" "1.030" "1.033" "1.013" "0.970" "1.096" "0.969" "0.961" "1.060" "1.112" "324.9" "334.5" "335.7" "329.2" "315.2" "356.1" "314.7" "312.3" "344.3" "361.3" "" "" "" "" "" "" "" "" "" "" "260.9" "241.4" "266.7" "220.5" "218.0" "267.2" "220.3" "228.1" "344.3" "293.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248162455227524541" "False" "High" "IsMasterProtein" "Q92636" "Protein FAN OS=Homo sapiens OX=9606 GN=NSMAF PE=1 SV=2" "0.000" "False" "12.897" "4" "4" "4" "4" "917" "104.3" "6.23" "14.47" "4" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02138, Pf02893" "8439" "ENSG00000035681" "NSMAF" "B4DFB0; E9PCH0; hsa:8439; Q8IW26; Q92636" "TNFR1-mediated ceramide production" "TNF-alpha signaling pathway; Orexin receptor pathway" "3" "0" "1.122" "1.156" "1.249" "1.143" "1.232" "1.085" "1.235" "1.100" "1.123" "48.6" "54.5" "56.1" "60.7" "55.5" "59.8" "52.7" "60.0" "53.4" "54.5" "" "" "" "" "" "" "" "" "" "" "39.0" "39.3" "44.6" "40.6" "38.4" "44.9" "36.9" "43.8" "53.4" "44.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538396539459298741" "False" "High" "IsMasterProtein" "Q9H6Q4" "Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1" "0.000" "False" "12.892" "7" "4" "4" "3" "476" "53.0" "7.23" "14.14" "4" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "other molecular function" "Pf02256, Pf02906" "64428" "ENSG00000103245" "CIAO3" "A1L385; B3KTJ3; hsa:64428; Q53GC6; Q96S10; Q9H6J8; Q9H6Q4" "Cytosolic iron-sulfur cluster assembly" "" "1" "1" "1.023" "0.995" "1.006" "1.005" "0.987" "0.982" "1.015" "0.976" "1.003" "455.6" "465.9" "453.2" "458.2" "458.1" "449.9" "447.3" "462.3" "444.9" "456.8" "" "" "" "" "" "" "" "" "" "" "366.0" "336.2" "360.0" "307.0" "316.8" "337.6" "313.2" "337.6" "444.9" "371.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6567734872650185245" "False" "High" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "0.000" "False" "12.883" "28" "2" "4" "2" "97" "10.9" "9.41" "16.41" "2" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "0.978" "1.011" "1.033" "0.998" "0.978" "0.918" "0.902" "0.981" "1.007" "792.8" "775.2" "801.1" "819.1" "791.1" "775.2" "727.8" "715.3" "778.0" "798.6" "" "" "" "" "" "" "" "" "" "" "636.8" "559.4" "636.4" "548.8" "547.1" "581.6" "509.5" "522.4" "778.0" "649.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457193127181059495" "False" "High" "IsMasterProtein" "Q8TDR0" "TRAF3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TRAF3IP1 PE=1 SV=1" "0.000" "False" "12.854" "3" "2" "2" "2" "691" "78.6" "7.93" "8.42" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf10243, Pf17749" "26146" "ENSG00000204104" "TRAF3IP1" "hsa:26146; Q6PCT1; Q7L8N9; Q8TDR0; Q9NRD6; Q9Y4Q1" "Intraflagellar transport" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 2q37 copy number variation syndrome; Bardet-Biedl syndrome" "6" "0" "1.106" "0.947" "1.220" "0.892" "1.034" "1.044" "0.983" "0.998" "0.954" "81.2" "89.8" "76.9" "99.0" "72.5" "84.0" "84.8" "79.9" "81.1" "77.5" "" "" "" "" "" "" "" "" "" "" "65.2" "64.8" "61.1" "66.4" "50.1" "63.0" "59.4" "58.3" "81.1" "63.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7919741535000260072" "False" "High" "IsMasterProtein" "Q96K80" "Zinc finger CCCH domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZC3H10 PE=1 SV=1" "0.000" "False" "12.849" "10" "3" "3" "3" "434" "46.0" "7.64" "8.53" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "84872" "ENSG00000135482" "ZC3H10" "hsa:84872; Q96K80" "" "" "0" "0" "1.224" "1.071" "1.075" "1.053" "1.173" "0.866" "0.935" "1.093" "1.121" "80.5" "98.5" "86.2" "86.6" "84.8" "94.5" "69.7" "75.3" "88.0" "90.3" "" "" "" "" "" "" "" "" "" "" "64.7" "71.1" "68.5" "58.0" "58.6" "70.9" "48.8" "55.0" "88.0" "73.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2050370214376890264" "False" "High" "IsMasterProtein" "O76075" "DNA fragmentation factor subunit beta OS=Homo sapiens OX=9606 GN=DFFB PE=1 SV=1" "0.000" "False" "12.847" "13" "4" "4" "4" "338" "39.1" "9.00" "9.38" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02017, Pf09230" "1677" "ENSG00000169598" "DFFB" "hsa:1677; O60521; O76075; Q5SR22; Q9BYI4; Q9BYI5; Q9BYI6" "Apoptosis induced DNA fragmentation" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "4" "0" "0.958" "0.869" "1.047" "0.906" "1.031" "1.108" "1.110" "1.101" "0.955" "32.4" "31.0" "28.1" "33.9" "29.3" "33.4" "35.9" "35.9" "35.7" "30.9" "" "" "" "" "" "" "" "" "" "" "26.0" "22.4" "22.3" "22.7" "20.3" "25.0" "25.1" "26.2" "35.7" "25.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6651828163835198711" "False" "High" "IsMasterProtein" "O95997" "Securin OS=Homo sapiens OX=9606 GN=PTTG1 PE=1 SV=1" "0.000" "False" "12.840" "14" "3" "3" "3" "202" "22.0" "6.60" "10.56" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04856" "9232" "ENSG00000164611" "PTTG1" "hsa:9232; O95997" "Separation of Sister Chromatids; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "5" "0" "1.200" "1.123" "0.928" "1.035" "1.131" "1.120" "1.279" "1.254" "1.229" "105.2" "126.2" "118.1" "97.6" "108.8" "119.0" "117.8" "134.5" "131.9" "129.2" "" "" "" "" "" "" "" "" "" "" "84.5" "91.1" "93.8" "65.4" "75.3" "89.3" "82.5" "98.2" "131.9" "105.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2037005348220660879" "False" "High" "IsMasterProtein" "O00151" "PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4" "0.000" "False" "12.834" "7" "2" "2" "2" "329" "36.0" "7.02" "8.64" "2" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "9124" "ENSG00000107438" "PDLIM1" "B2RBS6; hsa:9124; O00151; Q5VZH5; Q9BPZ9" "" "" "0" "0" "1.101" "0.961" "1.014" "1.117" "1.034" "1.078" "1.089" "1.037" "1.008" "199.3" "219.3" "191.5" "202.1" "222.5" "206.0" "214.8" "217.0" "206.6" "200.8" "" "" "" "" "" "" "" "" "" "" "160.1" "158.3" "152.1" "135.4" "153.9" "154.6" "150.4" "158.5" "206.6" "163.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623935666392123134" "False" "High" "IsMasterProtein" "Q8N653" "Leucine-zipper-like transcriptional regulator 1 OS=Homo sapiens OX=9606 GN=LZTR1 PE=1 SV=2" "0.000" "False" "12.830" "5" "4" "4" "4" "840" "94.7" "6.57" "12.74" "4" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00651, Pf01344, Pf13415, Pf13418" "8216" "ENSG00000099949" "LZTR1" "hsa:8216; Q14776; Q20WK0; Q8N653" "" "22q11.2 copy number variation syndrome" "1" "0" "0.852" "0.988" "0.946" "0.953" "0.974" "0.897" "0.846" "0.880" "1.007" "78.1" "66.6" "77.2" "74.0" "74.5" "76.1" "70.1" "66.1" "68.8" "78.7" "" "" "" "" "" "" "" "" "" "" "62.8" "48.0" "61.3" "49.5" "51.5" "57.1" "49.1" "48.3" "68.8" "64.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294747431044223143" "False" "High" "IsMasterProtein" "Q9UBN7" "Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2" "0.000" "False" "12.827" "2" "3" "3" "3" "1215" "131.3" "5.30" "10.51" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00850, Pf02148" "10013" "ENSG00000094631" "HDAC6" "hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7" "Late endosomal microautophagy; Cilium Assembly; Aggrephagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Transcriptional regulation by RUNX2; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "17" "0" "1.072" "1.035" "1.032" "1.077" "1.014" "1.040" "1.029" "1.018" "1.086" "328.0" "351.5" "339.6" "338.5" "353.3" "332.4" "341.1" "337.5" "334.0" "356.1" "" "" "" "" "" "" "" "" "" "" "263.4" "253.6" "269.8" "226.8" "244.3" "249.4" "238.8" "246.5" "334.0" "289.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8995657341512938219" "False" "High" "IsMasterProtein" "P47914" "Large ribosomal subunit protein eL29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "0.000" "False" "12.818" "14" "2" "3" "2" "159" "17.7" "11.66" "10.59" "2" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.028" "1.139" "0.973" "1.062" "1.083" "1.020" "0.960" "1.046" "1.125" "267.8" "275.3" "305.0" "260.5" "284.4" "290.0" "273.1" "257.2" "280.1" "301.2" "" "" "" "" "" "" "" "" "" "" "215.1" "198.6" "242.3" "174.5" "196.7" "217.6" "191.2" "187.8" "280.1" "244.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-323839447441261697" "False" "High" "IsMasterProtein" "Q9NWK9" "Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1" "0.000" "False" "12.811" "8" "4" "4" "4" "470" "53.9" "5.80" "11.64" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "54680" "ENSG00000117174" "ZNHIT6" "B2RBA1; B4DP13; D3DT20; hsa:54680; Q9H278; Q9H3X3; Q9NWK9; Q9NWN0" "" "" "0" "0" "0.995" "1.077" "0.984" "1.078" "1.037" "1.016" "1.065" "1.096" "1.087" "404.5" "402.4" "435.5" "398.1" "435.9" "419.6" "410.8" "430.8" "443.5" "439.7" "" "" "" "" "" "" "" "" "" "" "324.9" "290.4" "346.0" "266.7" "301.5" "314.8" "287.6" "314.6" "443.5" "357.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1418350428187629844" "False" "High" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "0.000" "False" "12.809" "41" "5" "7" "5" "99" "10.9" "9.57" "23.20" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "1.132" "1.035" "1.068" "1.114" "1.134" "1.152" "0.994" "0.990" "0.965" "103.6" "117.3" "107.2" "110.7" "115.4" "117.5" "119.4" "103.0" "102.6" "100.0" "" "" "" "" "" "" "" "" "" "" "83.2" "84.7" "85.2" "74.1" "79.8" "88.2" "83.6" "75.2" "102.6" "81.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6769080269671987288" "False" "High" "IsMasterProtein" "Q9NVP1" "ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2" "0.000" "False" "12.807" "5" "4" "4" "4" "670" "75.4" "9.50" "7.15" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "8886" "ENSG00000088205" "DDX18" "hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1" "" "" "0" "0" "1.127" "1.174" "1.206" "1.129" "1.071" "1.191" "1.210" "1.120" "1.174" "219.3" "247.2" "257.6" "264.5" "247.6" "234.9" "261.2" "265.4" "245.7" "257.4" "" "" "" "" "" "" "" "" "" "" "176.2" "178.4" "204.6" "177.2" "171.2" "176.2" "182.9" "193.8" "245.7" "209.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656121017139874826" "False" "High" "IsMasterProtein" "Q01081" "Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3" "0.000" "False" "12.807" "20" "4" "7" "4" "240" "27.9" "8.81" "14.76" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00642" "102724594; 7307" "ENSG00000160201" "U2AF1" "hsa:102724594; hsa:7307; Q01081; Q701P4; Q71RF1" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway" "mRNA processing" "5" "0" "1.121" "1.321" "1.172" "1.075" "1.150" "1.154" "1.285" "1.288" "1.166" "443.1" "496.9" "585.5" "519.5" "476.2" "509.6" "511.2" "569.2" "570.9" "516.4" "" "" "" "" "" "" "" "" "" "" "355.9" "358.5" "465.1" "348.0" "329.3" "382.4" "357.9" "415.7" "570.9" "420.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3436560803263431899" "False" "High" "IsMasterProtein" "P14921" "Protein C-ets-1 OS=Homo sapiens OX=9606 GN=ETS1 PE=1 SV=1" "0.000" "False" "12.793" "10" "4" "4" "4" "441" "50.4" "5.19" "12.10" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf19525" "2113" "ENSG00000134954" "ETS1" "A9UL17; F5GYX9; hsa:2113; P14921; Q14278; Q16080; Q6N087; Q96AC5" "Oncogene Induced Senescence" "Neural crest differentiation; B cell receptor signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Melanoma; Extrafollicular and follicular B cell activation by SARS-CoV-2" "11" "0" "0.961" "0.911" "0.868" "0.720" "0.787" "0.599" "0.578" "0.644" "0.799" "638.4" "613.7" "581.4" "554.0" "459.7" "502.2" "382.7" "368.7" "411.3" "510.4" "" "" "" "" "" "" "" "" "" "" "512.8" "442.8" "461.8" "371.2" "317.9" "376.8" "267.9" "269.3" "411.3" "415.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271689599031996441" "False" "High" "IsMasterProtein" "Q9H1K1" "Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2" "0.000" "False" "12.789" "14" "3" "4" "3" "167" "18.0" "9.48" "14.91" "3" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01592" "23479" "ENSG00000136003" "ISCU" "hsa:23479; Q6P713; Q99617; Q9H1K1; Q9H1K2" "Maturation of replicase proteins" "Iron-sulfur cluster biogenesis" "2" "0" "1.029" "1.021" "1.094" "0.945" "1.002" "0.960" "0.969" "0.956" "0.983" "866.7" "892.2" "884.9" "948.4" "818.8" "868.8" "832.1" "839.5" "828.6" "852.0" "" "" "" "" "" "" "" "" "" "" "696.1" "643.8" "702.9" "635.4" "566.3" "651.9" "582.6" "613.1" "828.6" "692.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6931862210339099933" "False" "High" "IsMasterProtein" "Q9H1B7" "Probable E3 ubiquitin-protein ligase IRF2BPL OS=Homo sapiens OX=9606 GN=IRF2BPL PE=1 SV=1" "0.000" "False" "12.770" "4" "3" "3" "3" "796" "82.6" "8.24" "6.22" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "64207" "ENSG00000119669" "IRF2BPL" "hsa:64207; Q8NDQ2; Q96JG2; Q9H1B7; Q9H3I7" "" "" "0" "0" "0.985" "0.886" "1.181" "1.024" "1.099" "1.180" "1.183" "1.147" "1.056" "241.5" "238.0" "213.8" "285.1" "247.3" "265.3" "284.9" "285.8" "277.0" "255.1" "" "" "" "" "" "" "" "" "" "" "194.0" "171.7" "169.9" "191.0" "171.0" "199.1" "199.5" "208.7" "277.0" "207.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5274992111862833065" "False" "High" "IsMasterProtein" "Q8IXJ6" "NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2" "0.000" "False" "12.765" "6" "2" "2" "2" "389" "43.2" "5.36" "8.66" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02146" "22933" "ENSG00000068903; ENSG00000283100" "SIRT2" "A8K3V1; B2RB45; hsa:22933; O95889; Q8IXJ6; Q924Y7; Q9P0G8; Q9UNT0; Q9Y6E9; U5TP13" "Initiation of Nuclear Envelope (NE) Reformation" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; HDAC6 interactions in the central nervous system" "5" "0" "1.019" "1.031" "1.318" "1.100" "0.966" "1.109" "1.164" "1.081" "1.124" "154.7" "157.6" "159.5" "203.9" "170.2" "149.5" "171.6" "180.1" "167.3" "173.9" "" "" "" "" "" "" "" "" "" "" "124.3" "113.7" "126.7" "136.6" "117.7" "112.2" "120.1" "131.5" "167.3" "141.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787657634019778386" "False" "High" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "0.000" "False" "12.757" "13" "3" "3" "3" "248" "27.6" "5.30" "10.68" "3" "other metabolic processes" "" "other molecular function" "Pf00657" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "1.235" "1.083" "1.289" "1.271" "1.131" "1.048" "1.080" "1.070" "1.017" "201.5" "248.9" "218.2" "259.7" "256.2" "227.9" "211.3" "217.5" "215.6" "204.9" "" "" "" "" "" "" "" "" "" "" "161.8" "179.6" "173.3" "174.0" "177.2" "171.0" "147.9" "158.9" "215.6" "166.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867666717425813757" "False" "High" "IsMasterProtein" "Q8IXM2" "Chromatin complexes subunit BAP18 OS=Homo sapiens OX=9606 GN=BAP18 PE=1 SV=1" "0.000" "False" "12.750" "17" "2" "2" "2" "172" "17.9" "7.33" "9.01" "2" "cell organization and biogenesis" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "124944" "ENSG00000258315" "BAP18" "B4DIV3; C9J4G0; E9PB29; hsa:124944; Q8IXM2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4000962258629935056" "False" "High" "IsMasterProtein" "P62847" "Small ribosomal subunit protein eS24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1" "0.000" "False" "12.734" "20" "2" "5" "2" "133" "15.4" "10.78" "13.89" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01282" "6229" "ENSG00000138326" "RPS24" "E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.931" "1.019" "1.061" "0.968" "1.055" "0.913" "1.012" "0.952" "0.986" "309.7" "288.5" "315.5" "328.5" "299.8" "326.8" "282.8" "313.3" "294.7" "305.5" "" "" "" "" "" "" "" "" "" "" "248.8" "208.2" "250.6" "220.1" "207.3" "245.2" "198.0" "228.8" "294.7" "248.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765317392758550042" "False" "High" "IsMasterProtein" "Q3T8J9" "GON-4-like protein OS=Homo sapiens OX=9606 GN=GON4L PE=1 SV=1" "0.000" "False" "12.720" "1" "3" "3" "3" "2241" "248.5" "5.01" "10.00" "3" "other biological processes" "nucleus" "other molecular function" "Pf02671, Pf21227" "54856" "ENSG00000116580" "GON4L" "B7ZBL4; hsa:54856; Q14C93; Q3T8J8; Q3T8J9; Q5VYZ5; Q5W0D5; Q6AWA6; Q6P1Q6; Q7Z3L3; Q8IY79; Q9BQI1; Q9HCG6" "" "" "0" "0" "1.237" "1.005" "1.364" "1.213" "1.014" "1.125" "1.147" "1.209" "1.089" "122.8" "151.9" "123.4" "167.5" "148.9" "124.5" "138.2" "140.8" "148.4" "133.7" "" "" "" "" "" "" "" "" "" "" "98.6" "109.6" "98.0" "112.2" "103.0" "93.4" "96.7" "102.8" "148.4" "108.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719462215085106760" "False" "High" "IsMasterProtein" "Q8N983" "Large ribosomal subunit protein mL43 OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" "0.000" "False" "12.710" "17" "4" "4" "4" "215" "23.4" "8.65" "11.95" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "84545" "ENSG00000055950" "MRPL43" "B1AL06; B1AL07; B1AL09; B1AL10; C9J5Q3; D3DR71; hsa:84545; Q5JW06; Q7Z719; Q7Z7H6; Q86XN1; Q8N983; Q9BYC7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.995" "0.990" "0.908" "1.027" "0.967" "0.971" "0.943" "0.976" "0.957" "342.3" "340.5" "339.0" "310.8" "351.4" "330.9" "332.3" "322.6" "334.0" "327.6" "" "" "" "" "" "" "" "" "" "" "274.9" "245.7" "269.2" "208.2" "243.0" "248.3" "232.7" "235.6" "334.0" "266.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2016868097673482949" "False" "High" "IsMasterProtein" "Q9GZY6" "Linker for activation of T-cells family member 2 OS=Homo sapiens OX=9606 GN=LAT2 PE=1 SV=1" "0.000" "False" "12.709" "10" "2" "4" "2" "243" "26.5" "4.78" "13.89" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15703" "7462" "ENSG00000086730" "LAT2" "A6NFK6; A8K209; A8K4F1; D3DXF9; hsa:7462; Q9BXX8; Q9GZY6; Q9NZY9" "Role of LAT2/NTAL/LAB on calcium mobilization" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome" "3" "0" "1.013" "1.042" "1.124" "1.082" "1.068" "1.080" "0.963" "1.023" "1.039" "209.0" "211.7" "217.8" "235.0" "226.1" "223.1" "225.8" "201.2" "213.9" "217.2" "" "" "" "" "" "" "" "" "" "" "167.9" "152.7" "173.0" "157.4" "156.3" "167.4" "158.1" "146.9" "213.9" "176.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4795865386403905334" "False" "High" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "0.000" "False" "12.697" "21" "3" "9" "3" "139" "15.3" "9.99" "22.91" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "Ciliary landscape" "3" "0" "1.100" "1.117" "1.057" "0.986" "1.082" "1.030" "0.994" "1.008" "1.054" "853.7" "938.8" "953.8" "902.6" "841.7" "923.5" "879.6" "848.7" "860.9" "900.0" "" "" "" "" "" "" "" "" "" "" "685.7" "677.4" "757.6" "604.8" "582.1" "692.9" "615.8" "619.8" "860.9" "731.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6729288942847254867" "False" "High" "IsMasterProtein" "P42684" "Tyrosine-protein kinase ABL2 OS=Homo sapiens OX=9606 GN=ABL2 PE=1 SV=1" "0.000" "False" "12.697" "4" "4" "4" "4" "1182" "128.3" "8.07" "6.74" "4" "cell adhesion;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714, Pf08919" "27" "ENSG00000143322" "ABL2" "A0M8X0; B7UEF2; B7UEF3; B7UEF4; B7UEF5; hsa:27; P42684; Q5T0X6; Q5W0C5; Q6NZY6; Q7Z301" "Role of ABL in ROBO-SLIT signaling; RAC1 GTPase cycle; RAC3 GTPase cycle; Negative regulation of FLT3" "Ras signaling; Acute viral myocarditis; ErbB signaling pathway" "7" "0" "1.209" "0.971" "1.496" "1.154" "1.078" "1.369" "1.269" "1.011" "1.226" "66.6" "80.5" "64.7" "99.6" "76.9" "71.8" "91.2" "84.5" "67.4" "81.7" "" "" "" "" "" "" "" "" "" "" "53.5" "58.1" "51.4" "66.8" "53.2" "53.9" "63.8" "61.7" "67.4" "66.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8564696200648567911" "False" "High" "IsMasterProtein" "O60930" "Ribonuclease H1 OS=Homo sapiens OX=9606 GN=RNASEH1 PE=1 SV=2" "0.000" "False" "12.696" "13" "2" "2" "2" "286" "32.0" "9.16" "7.95" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00075, Pf01693" "246243" "ENSG00000171865" "RNASEH1" "B3KQU4; hsa:246243; O60523; O60857; O60930; Q57Z93; Q5U0C1; Q6FHD4" "" "" "0" "0" "0.996" "0.948" "1.025" "1.163" "1.228" "1.063" "0.901" "1.122" "1.082" "119.5" "119.0" "113.3" "122.5" "138.9" "146.7" "127.1" "107.6" "134.0" "129.3" "" "" "" "" "" "" "" "" "" "" "96.0" "85.8" "90.0" "82.1" "96.1" "110.1" "89.0" "78.6" "134.0" "105.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5303653638395268189" "False" "High" "IsMasterProtein" "Q16633" "POU domain class 2-associating factor 1 OS=Homo sapiens OX=9606 GN=POU2AF1 PE=1 SV=1" "0.000" "False" "12.660" "12" "2" "4" "2" "256" "27.4" "4.94" "13.80" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf09310" "5450" "ENSG00000110777" "POU2AF1" "B2R8Z9; hsa:5450; Q14983; Q16633" "" "" "0" "0" "1.026" "0.962" "0.979" "0.981" "1.002" "0.875" "0.930" "0.973" "0.985" "427.3" "438.5" "411.2" "418.4" "419.3" "428.3" "373.8" "397.3" "415.9" "420.7" "" "" "" "" "" "" "" "" "" "" "343.2" "316.4" "326.7" "280.3" "290.0" "321.3" "261.7" "290.1" "415.9" "342.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870443060398404245" "False" "High" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "0.000" "False" "12.642" "23" "3" "3" "2" "130" "14.4" "9.11" "11.70" "3" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "1" "0.954" "1.021" "0.976" "0.979" "1.011" "1.015" "0.970" "0.999" "0.963" "671.2" "640.0" "685.5" "654.8" "657.0" "678.4" "681.6" "651.1" "670.3" "646.4" "" "" "" "" "" "" "" "" "" "" "539.1" "461.8" "544.5" "438.7" "454.4" "509.0" "477.2" "475.5" "670.3" "525.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2085339884306235514" "False" "High" "IsMasterProtein" "Q13501" "Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1" "0.000" "False" "12.642" "11" "4" "7" "4" "440" "47.7" "5.22" "19.43" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00564, Pf00569, Pf16577" "8878" "ENSG00000161011; ENSG00000284099" "SQSTM1" "A6NFN7; B2R661; B3KUW5; hsa:8878; Q13446; Q13501; Q9BUV7; Q9BVS6; Q9UEU1" "Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; Nuclear events mediated by NFE2L2; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy" "IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome; Opioid receptor pathways; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; HDAC6 interactions in the central nervous system" "24" "0" "0.916" "0.858" "1.098" "0.900" "0.883" "0.907" "1.004" "0.960" "1.061" "72.2" "66.2" "61.9" "79.3" "65.0" "63.7" "65.5" "72.5" "69.3" "76.6" "" "" "" "" "" "" "" "" "" "" "58.0" "47.7" "49.2" "53.1" "44.9" "47.8" "45.8" "52.9" "69.3" "62.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6268671224724585393" "False" "High" "IsMasterProtein" "P56945" "Breast cancer anti-estrogen resistance protein 1 OS=Homo sapiens OX=9606 GN=BCAR1 PE=1 SV=2" "0.000" "False" "12.637" "3" "2" "2" "2" "870" "93.3" "5.67" "7.36" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00018, Pf08824, Pf12026" "9564" "ENSG00000050820" "BCAR1" "B3KWD7; B4DEV4; B4DGB5; B4DIW5; B7Z7X7; E9PCL5; E9PCV2; F5GXA2; F5GXV6; F5H7Z0; F8WA69; hsa:9564; P56945; Q6QEF7" "Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; p130Cas linkage to MAPK signaling for integrins" "Integrin-mediated cell adhesion; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; miR-509-3p alteration of YAP1/ECM axis; EGF/EGFR signaling pathway; Gastrin signaling pathway; Regulation of actin cytoskeleton; GDNF signaling; NPHP1 deletion syndrome" "15" "0" "0.924" "0.974" "1.115" "1.119" "0.924" "1.062" "1.032" "1.166" "1.070" "181.7" "167.9" "176.9" "202.7" "203.4" "168.0" "193.0" "187.5" "211.9" "194.5" "" "" "" "" "" "" "" "" "" "" "145.9" "121.1" "140.5" "135.8" "140.6" "126.0" "135.1" "136.9" "211.9" "158.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8397270974056062959" "False" "High" "IsMasterProtein" "Q9NRL3" "Striatin-4 OS=Homo sapiens OX=9606 GN=STRN4 PE=1 SV=2" "0.000" "False" "12.635" "7" "4" "4" "4" "753" "80.5" "5.40" "12.09" "4" "" "other membranes;other cell component" "other molecular function" "Pf00400, Pf08232" "29888" "ENSG00000090372" "STRN4" "A0A024R0V2; B4DQH7; F8VYA6; hsa:29888; Q8NE53; Q9NRL3" "" "" "0" "0" "1.151" "0.952" "1.138" "1.002" "1.029" "1.057" "1.056" "1.084" "1.133" "209.8" "241.6" "199.8" "238.7" "210.2" "215.9" "221.8" "221.6" "227.5" "237.7" "" "" "" "" "" "" "" "" "" "" "168.5" "174.3" "158.7" "159.9" "145.4" "162.0" "155.3" "161.9" "227.5" "193.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4269157593658569788" "False" "High" "IsMasterProtein" "Q9NXV2" "BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1" "0.000" "False" "12.610" "10" "2" "2" "1" "234" "26.1" "6.24" "8.53" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02214" "54442" "ENSG00000167977" "KCTD5" "D3DU96; hsa:54442; Q9NXV2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824590419555307181" "False" "High" "IsMasterProtein" "P63165" "Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1" "0.000" "False" "12.597" "36" "4" "5" "4" "101" "11.6" "5.52" "13.03" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf11976" "7341" "ENSG00000116030" "SUMO1" "A8MUS8; B2R4I5; hsa:7341; P55856; P63165; Q6FGG0; Q6NZ62; Q93068" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of IFNG signaling; SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; PKR-mediated signaling; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "Androgen receptor signaling pathway; TP53 network; TGF-beta signaling pathway; Exercise-induced circadian regulation" "27" "0" "1.037" "1.032" "1.116" "1.042" "1.161" "1.207" "1.171" "1.066" "1.006" "489.8" "508.1" "505.3" "546.4" "510.1" "568.5" "591.3" "573.5" "522.0" "492.7" "" "" "" "" "" "" "" "" "" "" "393.4" "366.6" "401.4" "366.1" "352.8" "426.6" "414.0" "418.8" "522.0" "400.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408617602849881412" "False" "High" "IsMasterProtein" "Q9UKU7" "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1" "0.000" "False" "12.591" "9" "2" "2" "2" "415" "45.0" "7.85" "6.68" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "27034" "ENSG00000151498" "ACAD8" "B7Z5W4; hsa:27034; Q6ZWP6; Q9BUS8; Q9UKU7" "Branched-chain amino acid catabolism; Mitochondrial protein degradation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3817415269467879151" "False" "High" "IsMasterProtein" "P16435" "NADPH--cytochrome P450 reductase OS=Homo sapiens OX=9606 GN=POR PE=1 SV=2" "0.000" "False" "12.584" "5" "2" "2" "2" "677" "76.6" "5.58" "8.41" "2" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "5447" "ENSG00000127948" "POR" "P16435; Q16455; Q197M5; Q8N181; Q9H3M8; Q9UDT3" "Cytochrome P450 - arranged by substrate type" "Oxidation by cytochrome P450; Ferroptosis; 7q11.23 distal copy number variation" "4" "0" "1.104" "1.008" "1.015" "0.918" "1.102" "1.053" "1.069" "1.071" "1.075" "308.8" "340.9" "311.2" "313.6" "283.6" "340.3" "325.1" "330.2" "330.7" "331.9" "" "" "" "" "" "" "" "" "" "" "248.0" "246.0" "247.2" "210.1" "196.1" "255.3" "227.6" "241.1" "330.7" "269.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9165007621832030545" "False" "High" "IsMasterProtein" "Q7Z624" "Calmodulin-lysine N-methyltransferase OS=Homo sapiens OX=9606 GN=CAMKMT PE=1 SV=2" "0.000" "False" "12.563" "7" "2" "3" "2" "323" "36.1" "6.83" "9.40" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf10294" "79823" "ENSG00000143919" "CAMKMT" "hsa:79823; Q4ZG15; Q53SS6; Q7Z624; Q8N6P5; Q9H5G8" "Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation" "" "2" "0" "1.164" "1.120" "1.206" "1.286" "1.203" "1.259" "1.308" "1.191" "1.285" "134.0" "156.0" "150.1" "161.6" "172.4" "161.3" "168.7" "175.3" "159.7" "172.3" "" "" "" "" "" "" "" "" "" "" "107.6" "112.6" "119.2" "108.3" "119.2" "121.0" "118.1" "128.1" "159.7" "140.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002470481848011023" "False" "High" "IsMasterProtein" "Q9P032" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Homo sapiens OX=9606 GN=NDUFAF4 PE=1 SV=1" "0.000" "False" "12.550" "15" "3" "4" "3" "175" "20.3" "8.82" "13.08" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf06784" "29078" "ENSG00000123545" "NDUFAF4" "B2R4J5; hsa:29078; Q9P032" "Complex I biogenesis" "" "1" "0" "1.001" "1.053" "0.925" "0.974" "1.018" "0.848" "0.967" "1.019" "0.984" "500.9" "501.4" "527.7" "463.2" "488.0" "509.9" "424.8" "484.4" "510.6" "492.8" "" "" "" "" "" "" "" "" "" "" "402.3" "361.8" "419.1" "310.3" "337.5" "382.6" "297.4" "353.8" "510.6" "400.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4521329794053270042" "False" "High" "IsMasterProtein" "Q66K64" "DDB1- and CUL4-associated factor 15 OS=Homo sapiens OX=9606 GN=DCAF15 PE=1 SV=1" "0.000" "False" "12.538" "5" "3" "3" "3" "600" "66.4" "6.58" "6.99" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf14939" "90379" "ENSG00000132017; ENSG00000288453" "DCAF15" "B3KS86; hsa:90379; Q66K64; Q96DW0; Q9BU31" "" "" "0" "0" "1.018" "1.087" "1.164" "1.154" "1.152" "1.138" "1.092" "1.125" "1.082" "105.7" "107.6" "114.9" "123.1" "122.0" "121.8" "120.3" "115.5" "118.9" "114.3" "" "" "" "" "" "" "" "" "" "" "84.9" "77.6" "91.2" "82.5" "84.4" "91.4" "84.2" "84.3" "118.9" "93.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7972073683050353884" "False" "High" "IsMasterProtein" "Q9NYP3" "Protein downstream neighbor of Son OS=Homo sapiens OX=9606 GN=DONSON PE=1 SV=2" "0.000" "False" "12.525" "5" "2" "2" "2" "566" "62.7" "8.66" "7.14" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction" "nucleus;other cell component" "" "" "29980" "ENSG00000159147" "DONSON" "hsa:29980; Q8NC53; Q9NSR9; Q9NVZ5; Q9NYP1; Q9NYP2; Q9NYP3" "" "" "0" "0" "1.221" "0.971" "0.877" "1.557" "0.783" "1.282" "1.057" "1.242" "1.419" "23.1" "28.2" "22.4" "20.2" "36.0" "18.1" "29.6" "24.4" "28.7" "32.7" "" "" "" "" "" "" "" "" "" "" "18.5" "20.3" "17.8" "13.6" "24.9" "13.6" "20.7" "17.8" "28.7" "26.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3125031583536319160" "False" "High" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "0.000" "False" "12.514" "29" "3" "7" "3" "90" "9.4" "9.99" "18.94" "3" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "1.049" "1.079" "0.978" "1.128" "0.700" "1.030" "1.214" "1.282" "1.023" "926.2" "971.5" "999.0" "906.0" "1044.7" "648.6" "954.4" "1124.0" "1187.3" "947.1" "" "" "" "" "" "" "" "" "" "" "743.9" "701.0" "793.6" "607.0" "722.5" "486.6" "668.2" "820.8" "1187.3" "770.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137341147702067960" "False" "High" "IsMasterProtein" "P26440" "Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2" "0.000" "False" "12.442" "10" "4" "4" "4" "426" "46.6" "8.05" "11.04" "4" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "3712" "ENSG00000128928" "IVD" "B2RCV5; B3KVI7; hsa:3712; J3KR54; P26440; Q53XZ9; Q96AF6" "Branched-chain amino acid catabolism" "Valproic acid pathway" "2" "0" "0.942" "0.930" "1.093" "1.067" "1.058" "1.054" "0.908" "1.001" "1.111" "177.4" "167.1" "164.9" "193.9" "189.2" "187.6" "186.9" "161.1" "177.5" "197.1" "" "" "" "" "" "" "" "" "" "" "142.5" "120.6" "131.0" "129.9" "130.8" "140.8" "130.9" "117.6" "177.5" "160.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256308892199755457" "False" "High" "IsMasterProtein" "Q969J3" "BLOC-1-related complex subunit 5 OS=Homo sapiens OX=9606 GN=BORCS5 PE=1 SV=1" "0.000" "False" "12.436" "19" "3" "4" "3" "196" "22.2" "6.35" "11.43" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf10158" "118426" "ENSG00000165714; ENSG00000280689" "BORCS5" "hsa:118426; Q969J3; Q96QS5" "" "" "0" "0" "1.161" "1.061" "0.993" "1.131" "1.036" "1.072" "1.097" "1.019" "1.117" "115.9" "134.5" "123.0" "115.1" "131.1" "120.1" "124.3" "127.2" "118.1" "129.4" "" "" "" "" "" "" "" "" "" "" "93.1" "97.1" "97.7" "77.1" "90.7" "90.1" "87.0" "92.9" "118.1" "105.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1893119365438926918" "False" "High" "IsMasterProtein" "Q86UU0" "B-cell CLL/lymphoma 9-like protein OS=Homo sapiens OX=9606 GN=BCL9L PE=1 SV=1" "0.000" "False" "12.432" "2" "3" "3" "3" "1499" "157.0" "8.63" "11.75" "3" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf11502" "283149" "ENSG00000186174" "BCL9L" "A1A4C1; hsa:283149; Q67FY1; Q6ZWJ0; Q6ZWK2; Q86UU0" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex" "" "2" "0" "1.139" "1.085" "1.046" "1.102" "1.048" "0.955" "1.044" "1.141" "1.113" "387.2" "441.1" "420.2" "404.9" "426.8" "405.8" "369.7" "404.1" "441.8" "431.0" "" "" "" "" "" "" "" "" "" "" "311.0" "318.3" "333.8" "271.3" "295.2" "304.5" "258.8" "295.1" "441.8" "350.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3917086936507081280" "False" "High" "IsMasterProtein" "Q56P03" "E2F-associated phosphoprotein OS=Homo sapiens OX=9606 GN=EAPP PE=1 SV=4" "0.000" "False" "12.422" "5" "1" "2" "1" "285" "32.7" "5.12" "7.48" "1" "other biological processes" "nucleus;other cell component" "" "Pf10238" "55837" "ENSG00000129518" "EAPP" "hsa:55837; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86" "" "" "0" "0" "1.242" "1.225" "1.296" "1.311" "1.232" "1.056" "1.212" "1.366" "1.176" "111.9" "139.0" "137.1" "145.1" "146.8" "137.9" "118.2" "135.6" "152.9" "131.6" "" "" "" "" "" "" "" "" "" "" "89.9" "100.3" "108.9" "97.2" "101.5" "103.5" "82.8" "99.0" "152.9" "107.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980978827116582562" "False" "High" "IsMasterProtein" "Q07889" "Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1" "0.000" "False" "12.415" "3" "4" "4" "3" "1333" "152.4" "6.84" "13.59" "4" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00617, Pf00618, Pf00621" "6654" "ENSG00000115904" "SOS1" "A8K2G3; B4DXG2; hsa:6654; Q07889" "RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Acute myeloid leukemia; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "120" "1" "1.004" "1.007" "1.004" "1.003" "0.977" "1.114" "1.050" "1.064" "1.153" "168.4" "169.1" "169.7" "169.2" "169.0" "164.6" "187.6" "176.9" "179.3" "194.2" "" "" "" "" "" "" "" "" "" "" "135.3" "122.0" "134.8" "113.3" "116.9" "123.5" "131.4" "129.2" "179.3" "157.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1437377503696460912" "False" "High" "IsMasterProtein" "Q6Q0C0" "E3 ubiquitin-protein ligase TRAF7 OS=Homo sapiens OX=9606 GN=TRAF7 PE=1 SV=1" "0.000" "False" "12.411" "6" "4" "4" "4" "670" "74.6" "7.15" "12.38" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00400, Pf13445" "84231" "ENSG00000131653" "TRAF7" "hsa:84231; Q6Q0C0; Q9H073" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.089" "0.857" "1.092" "1.011" "0.984" "1.034" "0.891" "0.951" "0.955" "145.9" "158.9" "125.0" "159.4" "147.5" "143.6" "150.9" "129.9" "138.8" "139.3" "" "" "" "" "" "" "" "" "" "" "117.2" "114.6" "99.3" "106.8" "102.0" "107.7" "105.7" "94.9" "138.8" "113.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7284265241296169333" "False" "High" "IsMasterProtein" "Q56NI9" "N-acetyltransferase ESCO2 OS=Homo sapiens OX=9606 GN=ESCO2 PE=1 SV=1" "0.000" "False" "12.392" "6" "3" "3" "3" "601" "68.3" "9.39" "9.27" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13878, Pf13880" "157570" "ENSG00000171320" "ESCO2" "B3KW59; hsa:157570; Q49AP4; Q56NI9" "Establishment of Sister Chromatid Cohesion" "Cohesin complex - Cornelia de Lange syndrome" "2" "0" "0.882" "1.201" "0.874" "0.980" "0.938" "1.330" "1.472" "1.210" "0.724" "25.5" "22.5" "30.7" "22.3" "25.0" "24.0" "34.0" "37.6" "30.9" "18.5" "" "" "" "" "" "" "" "" "" "" "20.5" "16.3" "24.4" "14.9" "17.3" "18.0" "23.8" "27.4" "30.9" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-397251386471415027" "False" "High" "IsMasterProtein" "Q9Y3X0" "Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1" "0.000" "False" "12.371" "8" "3" "4" "3" "531" "59.7" "5.40" "8.93" "3" "" "nucleus" "nucleic acid binding activity" "Pf15266" "26093" "ENSG00000105321" "CCDC9" "hsa:26093; Q9Y3X0" "" "IL-18 signaling pathway" "1" "0" "0.725" "0.835" "0.937" "1.378" "1.233" "0.717" "1.409" "1.022" "0.763" "19.8" "14.3" "16.5" "18.5" "27.3" "24.4" "14.2" "27.9" "20.2" "15.1" "" "" "" "" "" "" "" "" "" "" "15.9" "10.3" "13.1" "12.4" "18.8" "18.3" "9.9" "20.4" "20.2" "12.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8635036141062544876" "False" "High" "IsMasterProtein" "P52655" "Transcription initiation factor IIA subunit 1 OS=Homo sapiens OX=9606 GN=GTF2A1 PE=1 SV=1" "0.000" "False" "12.366" "9" "3" "5" "3" "376" "41.5" "4.55" "16.95" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03153" "2957" "ENSG00000165417" "GTF2A1" "hsa:2957; P52655; Q3KNQ9" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "" "10" "0" "1.110" "0.974" "1.104" "1.047" "1.108" "0.993" "1.075" "0.972" "1.055" "200.2" "222.3" "195.0" "221.0" "209.6" "221.9" "198.8" "215.3" "194.6" "211.2" "" "" "" "" "" "" "" "" "" "" "160.8" "160.4" "154.9" "148.1" "145.0" "166.5" "139.2" "157.2" "194.6" "171.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6627210930524934042" "False" "High" "IsMasterProtein" "Q8TCF1" "AN1-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=ZFAND1 PE=1 SV=1" "0.000" "False" "12.365" "15" "3" "3" "3" "268" "30.8" "7.39" "10.01" "3" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf01428" "79752" "ENSG00000104231" "ZFAND1" "E5RIG0; E5RJ99; hsa:79752; Q658R7; Q6IA32; Q6PGQ6; Q8TCF1; Q9H810" "" "" "0" "0" "0.902" "0.883" "1.015" "0.897" "0.930" "0.960" "0.981" "0.902" "0.997" "167.0" "150.6" "147.5" "169.6" "149.8" "155.4" "160.3" "163.9" "150.7" "166.4" "" "" "" "" "" "" "" "" "" "" "134.1" "108.7" "117.2" "113.6" "103.6" "116.6" "112.2" "119.7" "150.7" "135.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421733537835387635" "False" "High" "IsMasterProtein" "Q9NPE2" "Neugrin OS=Homo sapiens OX=9606 GN=NGRN PE=1 SV=2" "0.000" "False" "12.359" "11" "3" "3" "3" "291" "32.4" "9.10" "9.45" "3" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf06413" "51335" "ENSG00000182768" "NGRN" "B2R6M8; hsa:51335; Q4V9L7; Q9HBL4; Q9NPE2" "" "" "0" "0" "0.955" "0.946" "1.087" "0.998" "0.925" "0.916" "0.938" "0.937" "0.951" "134.0" "127.9" "126.7" "145.6" "133.6" "123.9" "122.6" "125.6" "125.5" "127.4" "" "" "" "" "" "" "" "" "" "" "107.6" "92.3" "100.6" "97.6" "92.4" "93.0" "85.9" "91.7" "125.5" "103.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1068600970013118283" "False" "High" "IsMasterProtein" "Q99584" "Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1" "0.000" "False" "12.356" "28" "3" "4" "3" "98" "11.5" "6.16" "11.35" "3" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01023" "6284" "ENSG00000189171" "S100A13" "hsa:6284; Q52PI9; Q6FGF8; Q99584" "" "" "0" "0" "1.135" "1.118" "1.008" "1.009" "1.021" "1.305" "1.025" "1.042" "1.168" "85.2" "96.7" "95.2" "85.9" "86.0" "87.0" "111.1" "87.3" "88.7" "99.5" "" "" "" "" "" "" "" "" "" "" "68.4" "69.8" "75.6" "57.5" "59.5" "65.3" "77.8" "63.8" "88.7" "80.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7918333957511705273" "False" "High" "IsMasterProtein" "Q68D20" "Protein PMS2CL OS=Homo sapiens OX=9606 GN=PMS2CL PE=1 SV=1" "0.000" "False" "12.345" "18" "3" "3" "1" "193" "20.9" "5.34" "10.58" "3" "" "" "" "" "" "" "PMS2CL" "B4DK88; Q68D20; Q764P1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7172726289989085897" "False" "High" "IsMasterProtein" "Q8IYB5" "Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2" "0.000" "False" "12.329" "6" "3" "3" "2" "467" "50.4" "8.75" "10.65" "3" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "60682" "ENSG00000112305" "SMAP1" "hsa:60682; Q53H70; Q5SYQ2; Q6PK24; Q8IYB5; Q8NDH4; Q96L38; Q96L39; Q9H8X4" "" "" "0" "0" "1.069" "1.023" "1.019" "0.944" "1.088" "0.945" "0.977" "1.063" "1.035" "286.1" "305.8" "292.6" "291.5" "270.0" "311.2" "270.3" "279.6" "304.2" "296.2" "" "" "" "" "" "" "" "" "" "" "229.8" "220.6" "232.4" "195.3" "186.7" "233.5" "189.3" "204.2" "304.2" "240.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2096625671163089170" "False" "High" "IsMasterProtein" "O95999" "B-cell lymphoma/leukemia 10 OS=Homo sapiens OX=9606 GN=BCL10 PE=1 SV=1" "0.000" "False" "12.325" "15" "4" "5" "4" "233" "26.2" "5.74" "14.40" "4" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00619" "8915" "ENSG00000142867" "BCL10" "hsa:8915; O95999; Q5VUF1" "FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "9" "0" "1.022" "0.950" "1.020" "0.958" "0.951" "1.003" "0.946" "1.018" "0.978" "605.9" "619.1" "575.7" "617.8" "580.6" "576.2" "607.7" "573.1" "616.6" "592.8" "" "" "" "" "" "" "" "" "" "" "486.6" "446.7" "457.3" "413.9" "401.6" "432.3" "425.5" "418.6" "616.6" "482.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7185396298341420478" "False" "High" "IsMasterProtein" "Q13601" "KRR1 small subunit processome component homolog OS=Homo sapiens OX=9606 GN=KRR1 PE=1 SV=4" "0.000" "False" "12.311" "6" "2" "2" "2" "381" "43.6" "9.77" "8.01" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf17903, Pf21800" "11103" "ENSG00000111615" "KRR1" "A0FIK6; A0JLP0; B2R989; E7EUQ0; hsa:11103; Q13601; Q8NEA8; Q8TC37; Q96AT5" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.944" "0.989" "1.264" "0.927" "1.059" "1.141" "1.248" "1.094" "1.107" "29.8" "28.1" "29.4" "37.6" "27.6" "31.5" "34.0" "37.2" "32.6" "32.9" "" "" "" "" "" "" "" "" "" "" "23.9" "20.3" "23.4" "25.2" "19.1" "23.7" "23.8" "27.1" "32.6" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344595424207440426" "False" "High" "IsMasterProtein" "Q96RT8" "Gamma-tubulin complex component 5 OS=Homo sapiens OX=9606 GN=TUBGCP5 PE=1 SV=1" "0.000" "False" "12.308" "3" "3" "3" "3" "1024" "118.2" "5.90" "9.51" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf04130, Pf17681" "114791" "ENSG00000275835" "TUBGCP5" "E9PB12; hsa:114791; Q6IQ52; Q96PY8; Q96RT8" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "0.949" "1.112" "1.088" "1.207" "1.123" "1.224" "1.200" "1.204" "1.190" "180.5" "171.2" "200.6" "196.4" "217.8" "202.7" "220.9" "216.6" "217.3" "214.7" "" "" "" "" "" "" "" "" "" "" "144.9" "123.6" "159.3" "131.6" "150.6" "152.1" "154.7" "158.2" "217.3" "174.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6167412320153067815" "False" "High" "IsMasterProtein" "P35613" "Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2" "0.000" "False" "12.294" "7" "2" "3" "2" "385" "42.2" "5.66" "10.29" "2" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13927" "682" "ENSG00000172270" "BSG" "A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7" "Degradation of the extracellular matrix; Integrin cell surface interactions; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "10" "0" "1.115" "0.978" "1.171" "1.261" "1.221" "1.470" "1.108" "1.254" "1.247" "172.3" "192.1" "168.5" "201.7" "217.2" "210.3" "253.3" "190.8" "216.0" "214.8" "" "" "" "" "" "" "" "" "" "" "138.4" "138.6" "133.9" "135.2" "150.2" "157.8" "177.3" "139.4" "216.0" "174.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93736052394886069" "False" "High" "IsMasterProtein" "P50583" "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3" "0.000" "False" "12.229" "31" "4" "5" "4" "147" "16.8" "5.35" "12.17" "4" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00293" "318" "ENSG00000164978" "NUDT2" "D3DRM0; hsa:318; P50583; Q5T589" "Detoxification of Reactive Oxygen Species" "" "1" "0" "1.124" "1.069" "1.068" "1.127" "1.018" "1.068" "1.101" "1.001" "0.933" "298.6" "335.7" "319.3" "318.9" "336.6" "304.0" "319.0" "328.7" "299.0" "278.6" "" "" "" "" "" "" "" "" "" "" "239.8" "242.2" "253.7" "213.7" "232.8" "228.1" "223.3" "240.1" "299.0" "226.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1988329424413395185" "False" "High" "IsMasterProtein" "Q8WVK7" "Spindle and kinetochore-associated protein 2 OS=Homo sapiens OX=9606 GN=SKA2 PE=1 SV=1" "0.000" "False" "12.221" "35" "5" "6" "5" "121" "14.2" "7.33" "17.51" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf16740" "348235" "ENSG00000182628" "SKA2" "A6NIL3; B3KPL3; E9PCB8; hsa:348235; Q8WVK7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.028" "1.082" "1.037" "1.009" "1.057" "1.036" "1.096" "1.089" "1.081" "933.6" "959.5" "1010.1" "967.7" "942.0" "986.5" "967.2" "1022.9" "1016.9" "1008.9" "" "" "" "" "" "" "" "" "" "" "749.8" "692.3" "802.3" "648.4" "651.5" "740.2" "677.1" "747.0" "1016.9" "820.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173769377935829106" "False" "High" "IsMasterProtein" "Cont_P15497" "Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3" "0.000" "True" "12.216" "18" "5" "5" "5" "265" "30.3" "5.97" "12.56" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf01442" "281631" "ENSBIXG00000010441; ENSBIXG00005004093; ENSBTAG00000002258" "APOA1" "A0A4W2DWW2; A5D7M9; bta:281631; P15497; Q3SZD9; V6F9A2" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors" "Statin pathway; Folate metabolism; Vitamin B12 metabolism; Selenium micronutrient network" "15" "0" "0.836" "0.825" "0.835" "0.821" "0.895" "1.142" "0.840" "0.815" "0.874" "169.0" "141.3" "139.5" "141.0" "138.8" "151.2" "193.0" "142.0" "137.8" "147.7" "" "" "" "" "" "" "" "" "" "" "135.7" "102.0" "110.8" "94.5" "96.0" "113.5" "135.1" "103.7" "137.8" "120.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790786939717611867" "False" "High" "IsMasterProtein" "Q15723" "ETS-related transcription factor Elf-2 OS=Homo sapiens OX=9606 GN=ELF2 PE=1 SV=2" "0.000" "False" "12.204" "6" "3" "3" "3" "593" "63.9" "6.57" "6.29" "3" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1998" "ENSG00000109381" "ELF2" "E9PCX3; hsa:1998; Q15723; Q15724; Q15725; Q6P1K5" "RUNX1 regulates transcription of genes involved in BCR signaling" "" "1" "0" "0.912" "0.957" "1.116" "1.128" "1.006" "1.071" "1.008" "1.018" "0.998" "288.1" "262.8" "275.8" "321.4" "324.9" "289.7" "308.5" "290.3" "293.3" "287.6" "" "" "" "" "" "" "" "" "" "" "231.4" "189.7" "219.1" "215.4" "224.7" "217.4" "216.0" "212.0" "293.3" "233.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242437446693964013" "False" "High" "IsMasterProtein" "Q92997" "Segment polarity protein dishevelled homolog DVL-3 OS=Homo sapiens OX=9606 GN=DVL3 PE=1 SV=2" "0.000" "False" "12.155" "4" "3" "3" "2" "716" "78.0" "6.65" "6.92" "3" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1857" "ENSG00000161202" "DVL3" "B4E3E5; D3DNT0; hsa:1857; O14642; Q13531; Q8N5E9; Q92607; Q92997" "Degradation of DVL; RHO GTPases Activate Formins; WNT mediated activation of DVL; PCP/CE pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Joubert syndrome; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "24" "0" "0.885" "0.899" "1.043" "0.852" "1.029" "1.026" "0.838" "0.837" "0.933" "123.2" "109.0" "110.7" "128.4" "104.9" "126.7" "126.3" "103.3" "103.1" "114.9" "" "" "" "" "" "" "" "" "" "" "98.9" "78.7" "88.0" "86.0" "72.6" "95.1" "88.5" "75.4" "103.1" "93.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-788718536083084523" "False" "High" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "0.000" "False" "12.148" "9" "2" "3" "2" "285" "33.0" "5.17" "14.05" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "5" "0" "1.029" "0.998" "1.089" "1.090" "0.947" "1.080" "1.113" "0.962" "1.099" "81.5" "83.8" "81.3" "88.7" "88.8" "77.1" "88.0" "90.7" "78.4" "89.5" "" "" "" "" "" "" "" "" "" "" "65.4" "60.5" "64.6" "59.4" "61.4" "57.9" "61.6" "66.2" "78.4" "72.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2428159041387120762" "False" "High" "IsMasterProtein" "Q9Y664" "KICSTOR complex protein kaptin OS=Homo sapiens OX=9606 GN=KPTN PE=1 SV=2" "0.000" "False" "12.144" "8" "3" "3" "3" "436" "48.1" "5.26" "8.51" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "" "11133" "ENSG00000118162" "KPTN" "B3KN86; B4DQ76; hsa:11133; Q96GT1; Q9Y664" "Amino acids regulate mTORC1" "" "1" "0" "1.063" "1.022" "0.996" "1.009" "0.979" "1.010" "1.003" "0.940" "1.053" "418.1" "444.5" "427.4" "416.2" "421.8" "409.1" "422.4" "419.4" "392.9" "440.2" "" "" "" "" "" "" "" "" "" "" "335.8" "320.7" "339.5" "278.9" "291.7" "307.0" "295.7" "306.3" "392.9" "358.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2956941067343712987" "False" "High" "IsMasterProtein" "O75718" "Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1" "0.000" "False" "12.128" "8" "3" "3" "3" "401" "46.5" "5.73" "9.00" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "" "10491" "ENSG00000170275" "CRTAP" "B2RBL6; hsa:10491; O75718" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2507883408374064742" "False" "High" "IsMasterProtein" "O14874" "Branched-chain alpha-ketoacid dehydrogenase kinase OS=Homo sapiens OX=9606 GN=BCKDK PE=1 SV=2" "0.000" "False" "12.124" "8" "3" "3" "3" "412" "46.3" "8.82" "8.63" "3" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "10295" "ENSG00000103507" "BCKDK" "A8MY43; hsa:10295; O14874; Q6FGL4; Q96G95; Q96IN5" "Branched-chain amino acid catabolism" "Thiamine metabolic pathways" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4980915021063436064" "False" "High" "IsMasterProtein" "Q9H944" "Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1" "0.000" "False" "12.117" "18" "4" "6" "4" "212" "23.2" "6.87" "11.07" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08612" "9477" "ENSG00000124641" "MED20" "B4DE08; hsa:9477; O95821; Q5T8J4; Q9H944; Q9Y429" "Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "" "4" "0" "0.782" "0.857" "0.984" "0.695" "0.826" "0.877" "0.899" "0.901" "0.950" "31.6" "24.7" "27.1" "31.1" "22.0" "26.1" "27.8" "28.5" "28.5" "30.0" "" "" "" "" "" "" "" "" "" "" "25.4" "17.8" "21.5" "20.9" "15.2" "19.6" "19.4" "20.8" "28.5" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6473886272279589766" "False" "High" "IsMasterProtein" "Q9Y2X9" "Zinc finger protein 281 OS=Homo sapiens OX=9606 GN=ZNF281 PE=1 SV=1" "0.000" "False" "12.110" "4" "3" "3" "3" "895" "96.9" "8.48" "9.04" "3" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "23528" "ENSG00000162702" "ZNF281" "A6NF48; B3KMX2; hsa:23528; Q5RKW5; Q9NY92; Q9Y2X9" "" "Mesodermal commitment pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100203530818565223" "False" "High" "IsMasterProtein" "O00443" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2" "0.000" "False" "12.108" "2" "3" "5" "3" "1686" "190.6" "8.02" "14.52" "3" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5286" "ENSG00000011405" "PIK3C2A" "B0LPH2; B4E2G4; hsa:5286; O00443; Q14CQ9" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "14" "0" "1.022" "1.017" "0.904" "0.924" "0.932" "0.935" "0.975" "0.932" "0.910" "500.6" "511.7" "509.0" "452.7" "462.5" "466.4" "468.2" "488.2" "466.6" "455.7" "" "" "" "" "" "" "" "" "" "" "402.1" "369.2" "404.4" "303.3" "319.9" "349.9" "327.8" "356.5" "466.6" "370.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7453155325725910333" "False" "High" "IsMasterProtein" "Q9Y2K2" "Serine/threonine-protein kinase SIK3 OS=Homo sapiens OX=9606 GN=SIK3 PE=1 SV=4" "0.000" "False" "12.094" "3" "4" "6" "4" "1321" "144.8" "6.79" "18.30" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069" "23387" "ENSG00000160584" "SIK3" "A1A5A8; H0Y494; hsa:23387; J3KPC8; Q59FY2; Q5M9N1; Q6P3R6; Q8IYM8; Q9HA50; Q9Y2K2" "" "" "0" "0" "1.037" "1.130" "1.186" "1.128" "1.177" "1.063" "1.127" "1.178" "1.250" "164.2" "170.2" "185.6" "194.8" "185.1" "193.2" "174.5" "185.1" "193.4" "205.2" "" "" "" "" "" "" "" "" "" "" "131.9" "122.8" "147.4" "130.5" "128.0" "144.9" "122.2" "135.1" "193.4" "166.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904106809310251565" "False" "High" "IsMasterProtein" "Q9Y6X9" "ATPase MORC2 OS=Homo sapiens OX=9606 GN=MORC2 PE=1 SV=2" "0.000" "False" "12.077" "3" "3" "3" "3" "1032" "117.8" "8.38" "8.77" "3" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07496, Pf13589, Pf17942" "22880" "ENSG00000133422" "MORC2" "B2RNB1; hsa:22880; Q9UF28; Q9Y6V2; Q9Y6X9" "Fatty acyl-CoA biosynthesis" "" "1" "0" "0.961" "0.918" "0.977" "1.069" "1.091" "0.989" "0.969" "1.071" "0.986" "183.5" "176.3" "168.5" "179.2" "196.2" "200.3" "181.4" "177.7" "196.6" "181.0" "" "" "" "" "" "" "" "" "" "" "147.4" "127.2" "133.9" "120.1" "135.7" "150.3" "127.0" "129.8" "196.6" "147.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6300186880546044127" "False" "High" "IsMasterProtein" "O94829" "Importin-13 OS=Homo sapiens OX=9606 GN=IPO13 PE=1 SV=3" "0.000" "False" "12.065" "6" "4" "5" "4" "963" "108.1" "5.30" "11.14" "4" "transport" "nucleus;other cell component" "other molecular function" "Pf03810, Pf08389, Pf18773, Pf18786, Pf18806" "9670" "ENSG00000117408" "IPO13" "D3DPY4; hsa:9670; O94829; Q5T4X3; Q7LC04; Q96HS3; Q9H8N3; Q9UFR1" "" "" "0" "0" "1.096" "1.063" "1.100" "1.086" "1.165" "1.197" "1.181" "1.038" "1.397" "60.6" "66.4" "64.4" "66.6" "65.8" "70.6" "72.5" "71.6" "62.9" "84.7" "" "" "" "" "" "" "" "" "" "" "48.7" "47.9" "51.2" "44.6" "45.5" "53.0" "50.8" "52.3" "62.9" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6857356928160301149" "False" "High" "IsMasterProtein" "Q9C0E8" "Endoplasmic reticulum junction formation protein lunapark OS=Homo sapiens OX=9606 GN=LNPK PE=1 SV=2" "0.000" "False" "12.060" "5" "2" "2" "2" "428" "47.7" "5.11" "7.08" "2" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf10058" "80856" "ENSG00000144320" "LNPK" "B7ZLA8; hsa:80856; Q2M2V8; Q2YD99; Q658W8; Q8N5V9; Q96MS5; Q9C0E8" "" "" "0" "0" "1.061" "0.966" "0.993" "0.912" "1.094" "1.241" "1.073" "1.015" "1.087" "144.3" "153.1" "139.4" "143.3" "131.6" "158.0" "179.1" "154.8" "146.5" "157.0" "" "" "" "" "" "" "" "" "" "" "115.9" "110.5" "110.7" "96.0" "91.0" "118.5" "125.4" "113.1" "146.5" "127.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8727510044449713303" "False" "High" "IsMasterProtein" "Q9NVX0" "HAUS augmin-like complex subunit 2 OS=Homo sapiens OX=9606 GN=HAUS2 PE=1 SV=1" "0.000" "False" "12.058" "12" "3" "3" "3" "235" "26.9" "7.88" "11.99" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15003" "55142" "ENSG00000137814" "HAUS2" "C9JH36; hsa:55142; Q9H9B3; Q9NVX0" "Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414895648230328268" "False" "High" "IsMasterProtein" "Q92667" "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" "0.000" "False" "12.056" "3" "3" "4" "3" "903" "97.3" "4.94" "12.86" "3" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00013, Pf00567" "8165" "ENSG00000121057" "AKAP1" "A8K8Q1; D3DTZ0; hsa:8165; Q13320; Q92667; Q9BW14" "Factors involved in megakaryocyte development and platelet production; Mitochondrial calcium ion transport" "G protein signaling pathways" "3" "0" "1.042" "0.929" "1.024" "0.935" "0.983" "0.908" "0.978" "1.037" "1.085" "198.7" "207.1" "184.7" "203.5" "185.9" "195.4" "180.5" "194.4" "206.1" "215.5" "" "" "" "" "" "" "" "" "" "" "159.6" "149.4" "146.7" "136.4" "128.6" "146.6" "126.4" "142.0" "206.1" "175.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4248741172720899665" "False" "High" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "0.000" "False" "12.049" "29" "3" "5" "3" "92" "10.8" "9.44" "14.19" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.109" "1.103" "1.034" "0.927" "0.967" "0.908" "0.917" "0.891" "0.992" "178.8" "198.4" "197.3" "184.9" "165.8" "173.0" "162.4" "164.0" "159.4" "177.3" "" "" "" "" "" "" "" "" "" "" "143.6" "143.1" "156.7" "123.9" "114.6" "129.8" "113.7" "119.8" "159.4" "144.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5388836657935240768" "False" "High" "IsMasterProtein" "Q12872" "Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3" "0.000" "False" "12.039" "5" "4" "7" "4" "951" "104.8" "8.05" "13.90" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01805, Pf09750" "6433" "ENSG00000061936" "SFSWAP" "B2RN45; B7ZM97; F5H6B8; hsa:6433; Q12872; Q6PJF7" "" "mRNA processing" "1" "0" "1.049" "1.026" "1.163" "1.032" "0.975" "1.016" "1.036" "1.021" "1.073" "241.5" "253.2" "247.8" "280.7" "249.2" "235.5" "245.4" "250.2" "246.5" "259.1" "" "" "" "" "" "" "" "" "" "" "194.0" "182.7" "196.8" "188.1" "172.4" "176.7" "171.8" "182.7" "246.5" "210.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2514407203909916173" "False" "High" "IsMasterProtein" "O95363" "Phenylalanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=FARS2 PE=1 SV=1" "0.000" "False" "12.036" "7" "3" "3" "3" "451" "52.3" "7.46" "6.87" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf03147" "10667" "ENSG00000145982" "FARS2" "B2R664; hsa:10667; O95363; Q53F66; Q5TCS3; Q6FG29; Q9NPY7; Q9P062" "Mitochondrial tRNA aminoacylation" "" "1" "0" "0.817" "0.884" "1.012" "1.007" "0.961" "0.995" "1.198" "1.088" "1.016" "69.3" "56.6" "61.2" "70.1" "69.8" "66.6" "69.0" "83.0" "75.4" "70.4" "" "" "" "" "" "" "" "" "" "" "55.7" "40.9" "48.6" "47.0" "48.3" "49.9" "48.3" "60.6" "75.4" "57.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699883784093853229" "False" "High" "IsMasterProtein" "Q8IY47" "Kelch repeat and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KBTBD2 PE=1 SV=2" "0.000" "False" "12.029" "6" "4" "4" "4" "623" "71.3" "5.62" "10.85" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "25948" "ENSG00000170852" "KBTBD2" "A8K9T7; hsa:25948; Q86Y62; Q8IY47; Q9P239; Q9UFM7; Q9Y382" "" "" "0" "0" "1.024" "0.938" "0.997" "1.065" "0.969" "0.898" "0.918" "0.917" "1.022" "240.3" "246.1" "225.4" "239.5" "255.9" "232.8" "215.8" "220.6" "220.4" "245.6" "" "" "" "" "" "" "" "" "" "" "193.0" "177.6" "179.0" "160.4" "177.0" "174.7" "151.1" "161.1" "220.4" "199.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827998788629081219" "False" "High" "IsMasterProtein" "Q12834" "Cell division cycle protein 20 homolog OS=Homo sapiens OX=9606 GN=CDC20 PE=1 SV=2" "0.000" "False" "12.025" "9" "3" "3" "3" "499" "54.7" "9.23" "11.97" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf12894" "991" "ENSG00000117399" "CDC20" "B2R6Z6; D3DPJ1; hsa:991; Q12834; Q5JUY4; Q9BW56; Q9UQI9" "Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Ub-specific processing proteases; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; APC-Cdc20 mediated degradation of Nek2A; Phosphorylation of Emi1" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; HDAC6 interactions in the central nervous system" "23" "0" "1.066" "0.848" "1.060" "1.124" "0.923" "0.938" "0.834" "0.781" "0.977" "130.3" "138.9" "110.5" "138.0" "146.4" "120.2" "122.2" "108.7" "101.7" "127.2" "" "" "" "" "" "" "" "" "" "" "104.6" "100.2" "87.8" "92.5" "101.2" "90.2" "85.5" "79.4" "101.7" "103.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1443049690155721947" "False" "High" "IsMasterProtein" "Q9H0E2" "Toll-interacting protein OS=Homo sapiens OX=9606 GN=TOLLIP PE=1 SV=1" "0.000" "False" "12.006" "16" "4" "5" "4" "274" "30.3" "5.97" "14.95" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf02845" "54472" "ENSG00000078902; ENSG00000291426" "TOLLIP" "B3KXC6; hsa:54472; Q9H0E2; Q9H9E6; Q9UJ69" "Neutrophil degranulation; Interleukin-1 signaling" "IL-1 signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling related to MyD88; Signal transduction through IL1R; Toll-like receptor signaling pathway" "7" "0" "1.024" "0.994" "1.094" "0.913" "0.974" "1.093" "0.977" "0.891" "1.045" "60.7" "62.2" "60.4" "66.4" "55.4" "59.2" "66.4" "59.3" "54.1" "63.5" "" "" "" "" "" "" "" "" "" "" "48.8" "44.9" "48.0" "44.5" "38.3" "44.4" "46.5" "43.3" "54.1" "51.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379661527543753299" "False" "High" "IsMasterProtein" "Q6PID8" "Kelch domain-containing protein 10 OS=Homo sapiens OX=9606 GN=KLHDC10 PE=1 SV=1" "0.000" "False" "11.987" "8" "2" "2" "2" "442" "49.1" "9.38" "6.99" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13854" "23008" "ENSG00000128607" "KLHDC10" "hsa:23008; Q6PID8; Q86Y99; Q92554" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408450596310404748" "False" "High" "IsMasterProtein" "Q9UHA4" "Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1" "0.000" "False" "11.950" "27" "3" "4" "3" "124" "13.6" "7.34" "14.96" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08923" "8649" "ENSG00000109270" "LAMTOR3" "B2R4A1; hsa:8649; J3KMX4; Q9H364; Q9UHA4" "Amino acids regulate mTORC1; Neutrophil degranulation; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; MAP2K and MAPK activation; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma" "13" "0" "0.951" "1.011" "1.021" "1.028" "1.020" "1.182" "1.060" "0.936" "0.987" "171.1" "162.7" "172.9" "174.6" "175.8" "174.5" "202.2" "181.3" "160.1" "168.8" "" "" "" "" "" "" "" "" "" "" "137.4" "117.4" "137.4" "117.0" "121.6" "130.9" "141.6" "132.4" "160.1" "137.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864538005512546035" "False" "High" "IsMasterProtein" "P58005" "Sestrin-3 OS=Homo sapiens OX=9606 GN=SESN3 PE=1 SV=2" "0.000" "False" "11.939" "8" "3" "4" "3" "492" "57.3" "6.25" "10.31" "3" "stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04636" "143686" "ENSG00000149212" "SESN3" "B7Z7P9; hsa:143686; P58005; Q96AD1" "TP53 Regulates Metabolic Genes" "Angiopoietin-like protein 8 regulatory pathway; miRNA regulation of p53 pathway in prostate cancer" "3" "0" "1.260" "1.131" "1.362" "1.222" "1.102" "1.117" "1.222" "1.237" "1.226" "96.5" "121.6" "109.1" "131.4" "117.9" "106.3" "107.7" "117.9" "119.4" "118.3" "" "" "" "" "" "" "" "" "" "" "77.5" "87.7" "86.7" "88.0" "81.5" "79.8" "75.4" "86.1" "119.4" "96.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350737749617918576" "False" "High" "IsMasterProtein" "Q5TAQ9" "DDB1- and CUL4-associated factor 8 OS=Homo sapiens OX=9606 GN=DCAF8 PE=1 SV=1" "0.000" "False" "11.919" "5" "3" "3" "3" "597" "66.8" "5.39" "9.00" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400" "50717" "ENSG00000132716" "DCAF8" "D3DVE6; hsa:50717; Q12839; Q4QQI6; Q53F14; Q5TAQ9; Q66K50; Q68CS7; Q96E00" "Neddylation" "" "1" "0" "1.001" "0.964" "1.047" "0.972" "0.941" "0.871" "1.086" "1.009" "1.009" "289.9" "290.3" "279.6" "303.6" "281.7" "272.8" "252.5" "314.8" "292.5" "292.6" "" "" "" "" "" "" "" "" "" "" "232.8" "209.5" "222.1" "203.4" "194.8" "204.7" "176.8" "229.9" "292.5" "238.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2068779671623766038" "False" "High" "IsMasterProtein" "A6NJ78" "12S rRNA N4-methylcytidine (m4C) methyltransferase OS=Homo sapiens OX=9606 GN=METTL15 PE=1 SV=1" "0.000" "False" "11.915" "7" "2" "2" "2" "407" "46.1" "8.62" "8.00" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf01795" "196074" "ENSG00000169519" "METTL15" "A6NJ78; A8MRS5; B7WNU2; hsa:196074; Q3MHD3; Q8N601; Q8NBA7" "" "" "0" "0" "1.065" "0.970" "1.175" "1.019" "0.881" "1.027" "0.892" "1.071" "0.929" "79.0" "84.2" "76.7" "92.9" "80.5" "69.6" "81.2" "70.5" "84.7" "73.4" "" "" "" "" "" "" "" "" "" "" "63.5" "60.8" "60.9" "62.2" "55.7" "52.3" "56.8" "51.5" "84.7" "59.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-436575850023074270" "False" "High" "IsMasterProtein" "Q14164" "Inhibitor of nuclear factor kappa-B kinase subunit epsilon OS=Homo sapiens OX=9606 GN=IKBKE PE=1 SV=1" "0.000" "False" "11.915" "4" "3" "3" "3" "716" "80.4" "7.84" "10.07" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf18394, Pf18396" "9641" "ENSG00000263528" "IKBKE" "D3DT78; hsa:9641; Q14164; Q3B754; Q3KR43; Q5JTS6" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of TNFR1 signaling; TNFR1-induced proapoptotic signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; SUMOylation of immune response proteins" "MicroRNAs in cardiomyocyte hypertrophy; Cardiac hypertrophic response; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway" "25" "0" "0.985" "0.991" "1.050" "1.041" "0.964" "1.006" "0.930" "0.949" "1.006" "325.0" "320.0" "322.0" "341.3" "338.2" "313.2" "326.8" "302.3" "308.4" "327.0" "" "" "" "" "" "" "" "" "" "" "261.0" "230.9" "255.8" "228.7" "233.9" "235.0" "228.8" "220.8" "308.4" "265.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-979600656900959777" "False" "High" "IsMasterProtein" "Q9HD40" "O-phosphoseryl-tRNA(Sec) selenium transferase OS=Homo sapiens OX=9606 GN=SEPSECS PE=1 SV=2" "0.000" "False" "11.906" "6" "3" "3" "3" "501" "55.7" "8.05" "9.99" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05889" "51091" "ENSG00000109618" "SEPSECS" "A8K8W1; hsa:51091; Q0D2P3; Q17RT1; Q9HD40; Q9NXZ5; Q9UGM9; Q9Y353" "Selenocysteine synthesis" "Selenium metabolism and selenoproteins" "2" "0" "1.122" "1.022" "1.062" "1.168" "1.087" "1.043" "1.141" "0.985" "1.058" "279.4" "313.5" "285.5" "296.8" "326.3" "303.8" "291.5" "318.7" "275.2" "295.5" "" "" "" "" "" "" "" "" "" "" "224.4" "226.2" "226.8" "198.9" "225.7" "227.9" "204.1" "232.8" "275.2" "240.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8021819990662325449" "False" "High" "IsMasterProtein" "O43760" "Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1" "0.000" "False" "11.871" "16" "4" "5" "4" "224" "24.8" "4.94" "13.47" "4" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01284" "9144" "ENSG00000108639" "SYNGR2" "hsa:9144; O43760; O43762; Q3KQZ2; Q658S7" "" "" "0" "0" "0.985" "1.013" "1.068" "1.088" "1.005" "1.067" "0.991" "1.000" "1.024" "601.0" "592.1" "609.0" "641.7" "653.7" "603.8" "641.2" "595.7" "601.2" "615.7" "" "" "" "" "" "" "" "" "" "" "482.7" "427.2" "483.7" "430.0" "452.1" "453.0" "448.9" "435.0" "601.2" "500.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8274861477447348679" "False" "High" "IsMasterProtein" "Q96FA3" "E3 ubiquitin-protein ligase pellino homolog 1 OS=Homo sapiens OX=9606 GN=PELI1 PE=1 SV=2" "0.000" "False" "11.858" "7" "3" "5" "3" "418" "46.3" "8.03" "14.59" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04710, Pf20723" "57162" "ENSG00000197329" "PELI1" "Q96FA3; Q96SM0; Q9GZY5; Q9HCX0" "Regulation of necroptotic cell death; Interleukin-1 signaling; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation" "IL-1 signaling pathway" "5" "0" "1.000" "1.016" "0.974" "0.992" "1.037" "1.009" "1.081" "1.049" "1.063" "285.4" "285.4" "289.9" "277.9" "283.1" "295.9" "287.8" "308.5" "299.3" "303.3" "" "" "" "" "" "" "" "" "" "" "229.2" "206.0" "230.3" "186.2" "195.8" "222.0" "201.5" "225.3" "299.3" "246.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2509931178025596273" "False" "High" "IsMasterProtein" "Q5JSP0" "FYVE, RhoGEF and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FGD3 PE=1 SV=1" "0.000" "False" "11.838" "6" "4" "4" "4" "725" "79.4" "6.15" "12.41" "4" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "89846" "ENSG00000127084" "FGD3" "F8W7P2; hsa:89846; Q4VX84; Q5JSP0; Q7Z7D9; Q8N5G1" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "" "3" "0" "1.113" "1.062" "1.150" "1.045" "1.048" "1.025" "1.082" "1.074" "1.029" "257.6" "286.8" "273.7" "296.1" "269.1" "270.0" "264.0" "278.6" "276.6" "265.1" "" "" "" "" "" "" "" "" "" "" "206.9" "206.9" "217.4" "198.4" "186.1" "202.5" "184.8" "203.4" "276.6" "215.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3551068469878704149" "False" "High" "IsMasterProtein" "Q9H0U6" "Large ribosomal subunit protein uL18m OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1" "0.000" "False" "11.835" "15" "3" "7" "3" "180" "20.6" "9.54" "17.60" "3" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00861" "29074" "ENSG00000112110" "MRPL18" "hsa:29074; Q5TAP9; Q9H0U6; Q9NZW8" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "" "3" "0" "1.006" "1.069" "1.127" "1.050" "1.073" "1.103" "1.082" "1.011" "1.047" "299.4" "301.1" "320.2" "337.4" "314.2" "321.3" "330.3" "324.1" "302.8" "313.4" "" "" "" "" "" "" "" "" "" "" "240.5" "217.3" "254.3" "226.1" "217.3" "241.1" "231.3" "236.7" "302.8" "254.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-651184813655133351" "False" "High" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "0.000" "False" "11.819" "3" "2" "2" "2" "737" "83.7" "6.18" "8.15" "2" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "12" "0" "0.897" "0.907" "1.020" "1.232" "0.928" "1.232" "1.091" "1.074" "1.012" "236.7" "212.4" "214.7" "241.6" "291.6" "219.8" "291.6" "258.2" "254.2" "239.6" "" "" "" "" "" "" "" "" "" "" "190.1" "153.2" "170.5" "161.8" "201.7" "164.9" "204.2" "188.6" "254.2" "194.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6434237713970420089" "False" "High" "IsMasterProtein" "Q9Y291" "Small ribosomal subunit protein mS33 OS=Homo sapiens OX=9606 GN=MRPS33 PE=1 SV=1" "0.000" "False" "11.815" "30" "3" "3" "3" "106" "12.6" "10.11" "7.62" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08293" "51650" "ENSG00000090263" "MRPS33" "hsa:51650; Q9Y291" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.152" "1.002" "0.966" "1.024" "0.985" "0.946" "1.137" "0.990" "1.022" "472.0" "543.7" "473.0" "455.9" "483.5" "464.7" "446.3" "536.8" "467.4" "482.6" "" "" "" "" "" "" "" "" "" "" "379.1" "392.3" "375.7" "305.5" "334.4" "348.7" "312.5" "392.1" "467.4" "392.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2902136520496705703" "False" "High" "IsMasterProtein" "Q8N3F8" "MICAL-like protein 1 OS=Homo sapiens OX=9606 GN=MICALL1 PE=1 SV=2" "0.000" "False" "11.812" "6" "6" "6" "5" "863" "93.4" "7.25" "16.62" "6" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00307, Pf00412, Pf12130" "85377" "ENSG00000100139" "MICALL1" "hsa:85377; Q5TI16; Q7RTP5; Q8N3F8; Q8N3N8; Q9BVL9; Q9BY92; Q9UH43; Q9UH44; Q9UH45" "" "" "0" "0" "1.014" "0.966" "1.020" "1.037" "1.096" "1.029" "0.962" "1.125" "1.003" "404.3" "410.0" "390.4" "412.2" "419.1" "443.2" "416.1" "389.1" "454.7" "405.6" "" "" "" "" "" "" "" "" "" "" "324.7" "295.8" "310.1" "276.2" "289.9" "332.5" "291.3" "284.1" "454.7" "329.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6831775040715791940" "False" "High" "IsMasterProtein" "Q15043" "Metal cation symporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3" "0.000" "False" "11.810" "7" "2" "2" "2" "492" "54.2" "5.33" "8.08" "2" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "transporter activity" "Pf02535" "23516" "ENSG00000104635" "SLC39A14" "A6NH98; B4DIW3; B6EU88; D3DSR4; hsa:23516; Q15043; Q6ZME8; Q96BB3" "Zinc influx into cells by the SLC39 gene family" "Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis" "5" "0" "1.212" "1.055" "0.950" "1.143" "1.068" "1.405" "1.126" "1.094" "1.132" "103.9" "125.8" "109.5" "98.7" "118.7" "110.9" "145.9" "116.9" "113.7" "117.5" "" "" "" "" "" "" "" "" "" "" "83.4" "90.8" "87.0" "66.1" "82.1" "83.2" "102.2" "85.4" "113.7" "95.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728646887416176304" "False" "High" "IsMasterProtein" "Q8IYL3" "UPF0688 protein C1orf174 OS=Homo sapiens OX=9606 GN=C1orf174 PE=1 SV=2" "0.000" "False" "11.806" "7" "1" "1" "1" "243" "26.0" "6.90" "5.31" "1" "" "nucleus" "" "Pf15772" "339448" "ENSG00000198912" "C1orf174" "A8K0C8; A8MUG9; hsa:339448; Q5SR20; Q6NX36; Q8IYL3" "" "" "0" "0" "0.956" "0.747" "0.897" "0.794" "1.006" "0.848" "0.864" "0.973" "1.029" "35.9" "34.4" "26.9" "32.2" "28.5" "36.2" "30.5" "31.1" "35.0" "37.0" "" "" "" "" "" "" "" "" "" "" "28.9" "24.8" "21.3" "21.6" "19.7" "27.1" "21.3" "22.7" "35.0" "30.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8455796813251333225" "False" "High" "IsMasterProtein" "Q92750" "Transcription initiation factor TFIID subunit 4B OS=Homo sapiens OX=9606 GN=TAF4B PE=1 SV=2" "0.000" "False" "11.806" "2" "2" "2" "1" "862" "91.0" "9.54" "7.42" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6875" "ENSG00000141384" "TAF4B" "hsa:6875; Q29YA4; Q29YA5; Q92750" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "" "9" "0" "0.950" "0.843" "1.004" "1.047" "0.923" "0.986" "1.027" "0.921" "0.982" "55.4" "52.6" "46.7" "55.6" "58.0" "51.1" "54.6" "56.9" "51.0" "54.4" "" "" "" "" "" "" "" "" "" "" "44.5" "37.9" "37.1" "37.2" "40.1" "38.3" "38.2" "41.5" "51.0" "44.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2715206749087144500" "False" "High" "IsMasterProtein" "Q8WUR7" "UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2" "0.000" "False" "11.799" "8" "1" "2" "1" "153" "16.3" "9.83" "8.40" "1" "" "other cell component" "" "Pf02594" "123207" "ENSG00000169609" "C15orf40" "A6NIC9; B2R5E7; F5GX92; F8WD31; G5EA00; hsa:123207; Q8WUR7" "" "15q25 copy number variation" "1" "0" "1.100" "1.050" "1.225" "1.096" "1.014" "1.022" "1.283" "1.038" "1.045" "113.5" "124.8" "119.2" "139.0" "124.4" "115.0" "115.9" "145.6" "117.8" "118.6" "" "" "" "" "" "" "" "" "" "" "91.1" "90.0" "94.6" "93.1" "86.0" "86.3" "81.2" "106.3" "117.8" "96.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2730791661393038830" "False" "High" "IsMasterProtein" "Q9Y3P8" "Signaling threshold-regulating transmembrane adapter 1 OS=Homo sapiens OX=9606 GN=SIT1 PE=1 SV=1" "0.000" "False" "11.797" "6" "1" "2" "1" "196" "21.1" "6.30" "6.07" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "" "27240" "ENSG00000137078" "SIT1" "B2RBP9; hsa:27240; Q9Y3P8" "" "" "0" "0" "0.987" "0.889" "0.817" "0.765" "0.929" "0.781" "1.021" "1.053" "0.889" "47.9" "47.3" "42.6" "39.1" "36.6" "44.5" "37.4" "48.9" "50.5" "42.6" "" "" "" "" "" "" "" "" "" "" "38.5" "34.1" "33.8" "26.2" "25.3" "33.4" "26.2" "35.7" "50.5" "34.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5085231935458707065" "False" "High" "IsMasterProtein" "O75530" "Polycomb protein EED OS=Homo sapiens OX=9606 GN=EED PE=1 SV=2" "0.000" "False" "11.796" "10" "5" "5" "5" "441" "50.2" "7.03" "13.88" "5" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "8726" "ENSG00000074266" "EED" "A8K7V5; hsa:8726; O00149; O75530; Q6NTH2; Q7LDA5; Q7LDG8; Q86VV2; Q9UNY7" "Transcriptional Regulation by E2F6; HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; 5q35 copy number variation" "15" "0" "0.861" "0.973" "0.959" "0.922" "0.886" "1.029" "0.904" "0.979" "0.980" "623.1" "536.8" "606.6" "597.5" "574.4" "551.9" "641.2" "563.5" "610.2" "610.8" "" "" "" "" "" "" "" "" "" "" "500.5" "387.3" "481.8" "400.3" "397.3" "414.1" "448.9" "411.6" "610.2" "496.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "606148927883674097" "False" "High" "IsMasterProtein" "Q96AD5" "Patatin-like phospholipase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PNPLA2 PE=1 SV=1" "0.000" "False" "11.796" "6" "1" "1" "1" "504" "55.3" "7.08" "6.38" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01734" "57104" "ENSG00000177666" "PNPLA2" "hsa:57104; O60643; Q5EFF5; Q6XYE5; Q96AD5; Q96ET6; Q9NQ61; Q9NQ62" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Acyl chain remodeling of DAG and TAG" "Fatty acid beta-oxidation; Triacylglyceride synthesis; Lipid metabolism pathway; Thermogenesis; Glycerolipids and glycerophospholipids; Familial partial lipodystrophy; 5q35 copy number variation" "10" "0" "1.009" "0.797" "0.838" "0.866" "0.741" "0.833" "0.696" "0.809" "0.784" "48.9" "49.4" "39.0" "41.0" "42.4" "36.2" "40.7" "34.0" "39.6" "38.3" "" "" "" "" "" "" "" "" "" "" "39.3" "35.6" "31.0" "27.5" "29.3" "27.2" "28.5" "24.9" "39.6" "31.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8524788288681439212" "False" "High" "IsMasterProtein" "O15164" "Transcription intermediary factor 1-alpha OS=Homo sapiens OX=9606 GN=TRIM24 PE=1 SV=3" "0.000" "False" "11.777" "4" "3" "4" "3" "1050" "116.8" "7.11" "7.16" "3" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf00628, Pf00643" "8805" "ENSG00000122779" "TRIM24" "A4D1R7; A4D1R8; hsa:8805; O15164; O95854" "Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "3" "0" "0.852" "0.796" "0.974" "1.075" "0.889" "1.059" "1.097" "1.099" "0.961" "60.0" "51.1" "47.7" "58.5" "64.5" "53.4" "63.5" "65.8" "65.9" "57.7" "" "" "" "" "" "" "" "" "" "" "48.2" "36.9" "37.9" "39.2" "44.6" "40.0" "44.5" "48.1" "65.9" "46.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8164709769345228762" "False" "High" "IsMasterProtein" "Q9H4Z3" "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase OS=Homo sapiens OX=9606 GN=PCIF1 PE=1 SV=1" "0.000" "False" "11.769" "5" "4" "4" "4" "704" "80.6" "7.42" "10.66" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf12237" "63935" "ENSG00000100982" "PCIF1" "E1P5P1; hsa:63935; Q54AB9; Q9H4Z3; Q9NT85" "" "" "0" "0" "1.002" "0.954" "1.113" "0.981" "1.022" "0.964" "0.898" "0.963" "1.047" "391.3" "392.2" "373.5" "435.3" "383.9" "399.8" "377.2" "351.5" "376.7" "409.8" "" "" "" "" "" "" "" "" "" "" "314.3" "283.0" "296.6" "291.7" "265.5" "300.0" "264.1" "256.7" "376.7" "333.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8872418037025781977" "False" "High" "IsMasterProtein" "Q5VTB9" "E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens OX=9606 GN=RNF220 PE=1 SV=1" "0.000" "False" "11.765" "4" "2" "2" "2" "566" "62.7" "6.04" "8.30" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf15926" "55182" "ENSG00000187147" "RNF220" "B3KPJ3; B4DLZ9; E9PCS1; hsa:55182; Q4KMX2; Q5VTB9; Q9NVP6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.158" "0.956" "1.073" "1.002" "1.017" "0.964" "1.132" "1.119" "1.081" "72.4" "83.9" "69.2" "77.7" "72.6" "73.6" "69.8" "82.0" "81.0" "78.3" "" "" "" "" "" "" "" "" "" "" "58.1" "60.5" "55.0" "52.1" "50.2" "55.2" "48.9" "59.9" "81.0" "63.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2381350149897154971" "False" "High" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "0.000" "False" "11.743" "14" "4" "6" "4" "246" "28.0" "8.44" "16.76" "4" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RSV-host interactions; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins" "" "5" "0" "0.905" "0.871" "1.006" "0.956" "0.892" "1.011" "0.948" "0.965" "0.960" "567.4" "513.5" "494.2" "571.0" "542.3" "506.4" "573.4" "537.8" "547.5" "544.9" "" "" "" "" "" "" "" "" "" "" "455.7" "370.6" "392.6" "382.6" "375.1" "379.9" "401.5" "392.7" "547.5" "443.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8347450561102329946" "False" "High" "IsMasterProtein" "Q96BZ4" "5'-3' exonuclease PLD4 OS=Homo sapiens OX=9606 GN=PLD4 PE=1 SV=2" "0.000" "False" "11.712" "10" "5" "5" "5" "506" "55.6" "8.35" "9.90" "5" "DNA metabolism;stress response;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13918" "122618" "ENSG00000166428" "PLD4" "hsa:122618; Q6UWD2; Q96BZ4" "Role of phospholipids in phagocytosis; Synthesis of PG; Synthesis of IP3 and IP4 in the cytosol" "" "3" "0" "1.026" "0.944" "1.193" "1.006" "0.880" "0.867" "0.787" "0.870" "0.940" "148.3" "152.1" "140.0" "177.0" "149.2" "130.5" "128.6" "116.7" "129.0" "139.4" "" "" "" "" "" "" "" "" "" "" "119.1" "109.8" "111.2" "118.6" "103.2" "97.9" "90.0" "85.3" "129.0" "113.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8644531714570174079" "False" "High" "IsMasterProtein" "Q8WVM0" "Dimethyladenosine transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TFB1M PE=1 SV=1" "0.000" "False" "11.701" "7" "2" "2" "2" "346" "39.5" "9.26" "7.78" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00398" "51106" "ENSG00000029639" "TFB1M" "hsa:51106; Q05DR0; Q8WVM0; Q9Y384" "Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion" "Energy metabolism; Mitochondrial gene expression" "4" "0" "1.023" "1.062" "1.061" "1.114" "1.084" "0.962" "1.005" "1.000" "1.065" "177.9" "182.0" "188.9" "188.7" "198.1" "192.8" "171.2" "178.8" "177.8" "189.5" "" "" "" "" "" "" "" "" "" "" "142.9" "131.3" "150.0" "126.4" "137.0" "144.6" "119.8" "130.6" "177.8" "154.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-692133851352470930" "False" "High" "IsMasterProtein" "Q14376" "UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2" "0.000" "False" "11.697" "13" "3" "3" "3" "348" "38.3" "6.73" "7.74" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf16363" "2582" "ENSG00000117308" "GALE" "A0A024RAH5; B3KQ39; hsa:2582; Q14376; Q38G75; Q86W41; Q9BVE3; Q9UJB4" "Galactose catabolism; Defective GALE causes EDG" "Disorders of galactose metabolism ; UDP-derived sugars synthesis in fibroblasts" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808857115210323645" "False" "High" "IsMasterProtein" "Q9UFF9" "CCR4-NOT transcription complex subunit 8 OS=Homo sapiens OX=9606 GN=CNOT8 PE=1 SV=1" "0.000" "False" "11.680" "9" "2" "3" "2" "292" "33.5" "4.81" "7.82" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857" "9337" "ENSG00000155508" "CNOT8" "B0AZS3; B2RAR8; B7Z8R1; D3DQI8; hsa:9337; O95709; Q7Z521; Q9H6Y1; Q9UFF9" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "0.874" "0.804" "0.904" "0.658" "0.702" "0.894" "0.906" "0.980" "0.688" "29.6" "25.9" "23.8" "26.8" "19.5" "20.8" "26.5" "26.8" "29.1" "20.4" "" "" "" "" "" "" "" "" "" "" "23.8" "18.7" "18.9" "17.9" "13.5" "15.6" "18.6" "19.6" "29.1" "16.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4617078502424805251" "False" "High" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "0.000" "False" "11.665" "8" "5" "5" "5" "520" "60.7" "6.77" "8.07" "5" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "1.013" "0.920" "1.067" "1.106" "0.966" "1.162" "1.002" "0.982" "1.178" "104.7" "106.0" "96.3" "111.7" "115.8" "101.1" "121.7" "104.9" "102.8" "123.4" "" "" "" "" "" "" "" "" "" "" "84.1" "76.5" "76.5" "74.9" "80.1" "75.9" "85.2" "76.6" "102.8" "100.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5696513608973606523" "False" "High" "IsMasterProtein" "Q86VQ1" "Glucocorticoid-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=GLCCI1 PE=1 SV=1" "0.000" "False" "11.663" "4" "2" "3" "2" "547" "58.0" "9.44" "10.88" "2" "" "other cell component" "" "Pf15388" "113263" "ENSG00000106415" "GLCCI1" "A4D103; hsa:113263; Q86VQ1; Q96FD0" "" "" "0" "0" "1.046" "1.022" "1.056" "0.958" "1.014" "0.958" "0.964" "1.055" "0.952" "411.5" "430.3" "420.4" "434.6" "394.1" "417.1" "394.3" "396.8" "434.2" "391.7" "" "" "" "" "" "" "" "" "" "" "330.5" "310.5" "334.0" "291.2" "272.6" "312.9" "276.0" "289.8" "434.2" "318.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585910940532122349" "False" "High" "IsMasterProtein" "Q5U5X0" "Complex III assembly factor LYRM7 OS=Homo sapiens OX=9606 GN=LYRM7 PE=1 SV=1" "0.000" "False" "11.660" "25" "2" "2" "2" "104" "11.9" "9.66" "8.65" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf05347" "90624" "ENSG00000186687" "LYRM7" "A8MPQ9; hsa:90624; Q5U5X0; Q86Y68" "" "Mitochondrial complex III assembly" "1" "0" "1.076" "1.043" "1.232" "1.301" "1.127" "1.279" "1.279" "1.059" "1.192" "166.6" "179.3" "173.7" "205.1" "216.6" "187.8" "213.1" "213.0" "176.4" "198.6" "" "" "" "" "" "" "" "" "" "" "133.8" "129.4" "137.9" "137.4" "149.8" "140.9" "149.2" "155.6" "176.4" "161.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3081581238024006114" "False" "High" "IsMasterProtein" "Q96S99" "Pleckstrin homology domain-containing family F member 1 OS=Homo sapiens OX=9606 GN=PLEKHF1 PE=1 SV=3" "0.000" "False" "11.653" "6" "2" "6" "1" "279" "31.2" "8.24" "20.90" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00169, Pf01363" "79156" "ENSG00000166289" "PLEKHF1" "hsa:79156; Q96K11; Q96S99; Q9BUB9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2873927276967630041" "False" "High" "IsMasterProtein" "Q2TAZ0" "Autophagy-related protein 2 homolog A OS=Homo sapiens OX=9606 GN=ATG2A PE=1 SV=3" "0.000" "False" "11.649" "2" "4" "4" "4" "1938" "212.7" "5.88" "10.56" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624" "23130" "ENSG00000110046" "ATG2A" "hsa:23130; O43154; Q14DM2; Q2TAZ0; Q6ZTV2; Q7Z6K8; Q8IVY5; Q8TAI8; Q96HH7" "" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "4" "0" "1.160" "0.875" "1.026" "1.093" "1.078" "0.992" "1.093" "1.084" "1.106" "89.8" "104.1" "78.6" "92.1" "98.2" "96.8" "89.0" "98.1" "97.4" "99.3" "" "" "" "" "" "" "" "" "" "" "72.1" "75.1" "62.4" "61.7" "67.9" "72.6" "62.3" "71.7" "97.4" "80.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4201705345580193530" "False" "High" "IsMasterProtein" "Q969F9" "BLOC-2 complex member HPS3 OS=Homo sapiens OX=9606 GN=HPS3 PE=1 SV=1" "0.000" "False" "11.649" "4" "4" "4" "4" "1004" "113.7" "6.43" "11.79" "4" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle;other cell component" "" "Pf14761, Pf14763" "84343" "ENSG00000163755" "HPS3" "A8K6G6; hsa:84343; Q8WTV6; Q969F9; Q96AP1; Q96MR3; Q9H608" "" "" "0" "0" "1.406" "0.903" "1.266" "1.061" "1.027" "0.873" "0.966" "1.141" "1.047" "44.8" "63.0" "40.5" "56.7" "47.5" "46.0" "39.1" "43.3" "51.1" "46.9" "" "" "" "" "" "" "" "" "" "" "36.0" "45.4" "32.1" "38.0" "32.9" "34.5" "27.4" "31.6" "51.1" "38.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7820090330366172225" "False" "High" "IsMasterProtein" "Cont_Q7RTS7" "Keratin, type II cytoskeletal 74 OS=Homo sapiens OX=9606 GN=KRT74 PE=1 SV=2" "0.000" "True" "11.641" "6" "3" "7" "2" "529" "57.8" "7.71" "20.66" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208" "121391" "ENSG00000170484" "KRT74" "B5MD61; hsa:121391; Q7RTS7; Q86Y45" "Formation of the cornified envelope" "" "2" "0" "0.715" "0.249" "0.357" "0.665" "1.119" "1.731" "0.779" "0.573" "0.853" "427.8" "306.0" "106.7" "152.9" "284.6" "478.6" "740.6" "333.1" "245.0" "365.1" "" "" "" "" "" "" "" "" "" "" "343.6" "220.8" "84.8" "102.5" "196.8" "359.1" "518.5" "243.3" "245.0" "296.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5735228591980069382" "False" "High" "IsMasterProtein" "Q9HD42" "Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1" "0.000" "False" "11.637" "20" "6" "10" "6" "196" "21.7" "8.06" "20.82" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "5119" "ENSG00000131165" "CHMP1A" "A2RU09; hsa:5119; Q14468; Q15779; Q96G31; Q9HD42" "HCMV Late Events" "" "1" "0" "0.983" "1.034" "1.009" "1.022" "1.105" "1.063" "1.066" "1.136" "1.049" "722.0" "710.0" "746.9" "728.3" "737.8" "798.2" "767.4" "769.6" "820.1" "757.6" "" "" "" "" "" "" "" "" "" "" "579.9" "512.3" "593.3" "488.0" "510.3" "598.9" "537.3" "562.1" "820.1" "616.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-265901885640742242" "False" "High" "IsMasterProtein" "Q03164" "Histone-lysine N-methyltransferase 2A OS=Homo sapiens OX=9606 GN=KMT2A PE=1 SV=5" "0.000" "False" "11.637" "0" "1" "2" "1" "3969" "431.5" "9.09" "7.31" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771" "4297" "ENSG00000118058" "KMT2A" "E9PQG7; hsa:4297; Q03164; Q13743; Q13744; Q14845; Q16364; Q59FF2; Q6UBD1; Q9HBJ3; Q9UD94; Q9UMA3" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation of granulopoiesis" "Histone modifications" "6" "0" "1.027" "0.907" "1.466" "0.857" "0.928" "1.423" "1.228" "1.016" "1.068" "19.2" "19.8" "17.4" "28.2" "16.5" "17.9" "27.4" "23.6" "19.5" "20.5" "" "" "" "" "" "" "" "" "" "" "15.4" "14.3" "13.9" "18.9" "11.4" "13.4" "19.2" "17.2" "19.5" "16.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2071252542434870891" "False" "High" "IsMasterProtein" "Q5VU43" "Myomegalin OS=Homo sapiens OX=9606 GN=PDE4DIP PE=1 SV=3" "0.000" "False" "11.626" "1" "3" "3" "3" "2346" "264.9" "5.47" "6.45" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06758, Pf07989" "9659" "ENSG00000178104" "PDE4DIP" "A0A0A0MRM0; A0A0C4DFQ0; A2RU15; E9PL24; hsa:9659; O75042; O75065; Q2YDC1; Q5VU42; Q5VU43; Q5VU44; Q5VU45; Q5VU46; Q5VU47; Q5VU48; Q5VU49; Q68DU2; Q6AZ93; Q6PK88; Q86T40; Q86TB2; Q8N3W0; Q8TAY9; Q9HCP2; Q9HCP3; Q9HCP4; Q9HCP5" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.149" "1.061" "1.106" "1.039" "0.995" "1.117" "1.015" "1.038" "1.020" "308.9" "355.0" "327.7" "341.8" "320.8" "307.2" "344.9" "313.6" "320.6" "315.0" "" "" "" "" "" "" "" "" "" "" "248.1" "256.2" "260.3" "229.0" "221.9" "230.5" "241.5" "229.0" "320.6" "256.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214504578644122811" "False" "High" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "0.000" "False" "11.625" "13" "1" "8" "1" "108" "11.9" "8.16" "24.15" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "14" "0" "1.100" "0.865" "1.254" "1.046" "1.177" "1.105" "1.118" "0.986" "1.032" "529.8" "582.7" "458.1" "664.6" "553.9" "623.4" "585.6" "592.1" "522.6" "546.9" "" "" "" "" "" "" "" "" "" "" "425.5" "420.4" "363.9" "445.2" "383.1" "467.7" "410.0" "432.4" "522.6" "444.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6886715533770445791" "False" "High" "IsMasterProtein" "P23025" "DNA repair protein complementing XP-A cells OS=Homo sapiens OX=9606 GN=XPA PE=1 SV=1" "0.000" "False" "11.600" "15" "2" "2" "2" "273" "31.3" "6.73" "8.45" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01286, Pf05181" "7507" "ENSG00000136936" "XPA" "hsa:7507; P23025; Q5T1U9; Q6LCW7; Q6LD02" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "7" "0" "1.235" "1.049" "1.276" "1.132" "1.036" "1.040" "1.051" "1.058" "0.985" "113.4" "140.0" "118.9" "144.7" "128.4" "117.5" "118.0" "119.1" "119.9" "111.7" "" "" "" "" "" "" "" "" "" "" "91.1" "101.1" "94.5" "96.9" "88.8" "88.1" "82.6" "87.0" "119.9" "90.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "284975731923891311" "False" "High" "IsMasterProtein" "Q14644" "Ras GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=RASA3 PE=1 SV=3" "0.000" "False" "11.580" "8" "5" "5" "5" "834" "95.6" "7.15" "10.66" "5" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "transporter activity;enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "22821" "ENSG00000185989; ENSG00000280477" "RASA3" "A6NL15; F8W6X8; hsa:22821; Q14644; Q8IUY2" "Regulation of RAS by GAPs" "MAPK cascade; Ras signaling; IL-18 signaling pathway" "4" "0" "1.223" "1.181" "1.189" "1.176" "1.191" "1.131" "1.201" "1.191" "1.316" "94.2" "115.2" "111.2" "112.0" "110.8" "112.1" "106.6" "113.1" "112.2" "123.9" "" "" "" "" "" "" "" "" "" "" "75.7" "83.1" "88.3" "75.1" "76.6" "84.1" "74.6" "82.6" "112.2" "100.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-143757823348630571" "False" "High" "IsMasterProtein" "Q8IV08" "5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1" "0.000" "False" "11.573" "6" "3" "3" "3" "490" "54.7" "6.47" "9.57" "3" "DNA metabolism;stress response;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf13918" "23646" "ENSG00000105223" "PLD3" "hsa:23646; Q8IV08; Q92853; Q9BW87" "Role of phospholipids in phagocytosis; Synthesis of PG" "" "2" "0" "0.932" "1.115" "0.876" "1.143" "1.029" "1.103" "1.071" "0.952" "1.058" "133.0" "123.9" "148.3" "116.5" "152.0" "136.8" "146.6" "142.4" "126.6" "140.7" "" "" "" "" "" "" "" "" "" "" "106.8" "89.4" "117.8" "78.1" "105.1" "102.7" "102.7" "104.0" "126.6" "114.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5271819707192533656" "False" "High" "IsMasterProtein" "Q9H7E9" "UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8orf33 PE=1 SV=1" "0.000" "False" "11.558" "15" "3" "4" "3" "229" "25.0" "9.95" "11.53" "3" "" "" "" "Pf15393" "65265" "ENSG00000182307; ENSG00000291362" "C8orf33" "A6NGC0; hsa:65265; Q96BT8; Q9H7E9" "" "" "0" "0" "1.140" "1.160" "1.158" "1.064" "0.977" "1.040" "1.099" "1.049" "1.061" "132.0" "150.5" "153.2" "152.9" "140.5" "129.0" "137.4" "145.1" "138.5" "140.1" "" "" "" "" "" "" "" "" "" "" "106.0" "108.6" "121.7" "102.5" "97.2" "96.8" "96.2" "106.0" "138.5" "113.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3328900627537449382" "False" "High" "IsMasterProtein" "Q03111" "Protein ENL OS=Homo sapiens OX=9606 GN=MLLT1 PE=1 SV=2" "0.000" "False" "11.527" "5" "3" "5" "3" "559" "62.0" "8.59" "10.05" "3" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf03366, Pf17793" "4298" "ENSG00000130382" "MLLT1" "hsa:4298; Q03111; Q14768" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "1.046" "0.960" "1.091" "1.067" "0.993" "1.161" "1.134" "1.288" "1.357" "48.7" "51.0" "46.8" "53.2" "52.0" "48.4" "56.5" "55.2" "62.7" "66.1" "" "" "" "" "" "" "" "" "" "" "39.1" "36.8" "37.1" "35.6" "35.9" "36.3" "39.6" "40.3" "62.7" "53.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4366826834122666967" "False" "High" "IsMasterProtein" "Q92966" "snRNA-activating protein complex subunit 3 OS=Homo sapiens OX=9606 GN=SNAPC3 PE=1 SV=1" "0.000" "False" "11.522" "12" "4" "4" "4" "411" "46.7" "5.27" "12.64" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12251" "6619" "ENSG00000164975" "SNAPC3" "D3DRI8; hsa:6619; Q2VPI6; Q5T285; Q92966" "RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "" "3" "0" "0.968" "1.051" "1.002" "1.015" "0.983" "0.871" "0.950" "1.052" "0.999" "183.1" "177.2" "192.4" "183.5" "185.9" "180.0" "159.5" "173.9" "192.5" "182.9" "" "" "" "" "" "" "" "" "" "" "147.1" "127.8" "152.9" "122.9" "128.6" "135.0" "111.7" "127.0" "192.5" "148.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475093268658479309" "False" "High" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "0.000" "False" "11.506" "20" "3" "4" "3" "178" "20.4" "5.03" "12.94" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "" "Metapathway biotransformation Phase I and II" "1" "0" "0.878" "0.925" "1.095" "0.963" "0.911" "1.064" "0.909" "0.964" "0.980" "186.6" "164.0" "172.7" "204.3" "179.7" "170.1" "198.6" "169.7" "179.9" "182.8" "" "" "" "" "" "" "" "" "" "" "149.9" "118.3" "137.2" "136.9" "124.3" "127.6" "139.0" "124.0" "179.9" "148.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1239693809215146352" "False" "High" "IsMasterProtein" "P37275" "Zinc finger E-box-binding homeobox 1 OS=Homo sapiens OX=9606 GN=ZEB1 PE=1 SV=2" "0.000" "False" "11.505" "2" "2" "2" "2" "1124" "124.0" "4.94" "7.22" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf05605" "6935" "ENSG00000148516" "ZEB1" "B4DJV0; B4DUW9; E9PCM7; F5H4I8; hsa:6935; P37275; Q12924; Q13800; Q2KJ05; Q5T968; Q5VZ84; Q8NB68" "Interleukin-4 and Interleukin-13 signaling" "Hypoxia-mediated EMT and stemness; TGF-beta signaling pathway; Clear cell renal cell carcinoma pathways; Epithelial to mesenchymal transition in colorectal cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; CCL18 signaling pathway; Hypertrophy model" "8" "0" "1.045" "1.169" "1.224" "1.157" "1.103" "1.223" "1.170" "1.261" "1.208" "173.8" "181.6" "203.3" "212.7" "201.2" "191.7" "212.7" "203.3" "219.1" "210.1" "" "" "" "" "" "" "" "" "" "" "139.6" "131.1" "161.5" "142.5" "139.1" "143.8" "148.9" "148.5" "219.1" "170.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115979113467782463" "False" "High" "IsMasterProtein" "Q9Y2R4" "Probable ATP-dependent RNA helicase DDX52 OS=Homo sapiens OX=9606 GN=DDX52 PE=1 SV=4" "0.000" "False" "11.498" "5" "3" "3" "3" "599" "67.4" "9.67" "10.86" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "11056" "ENSG00000277594; ENSG00000278053" "DDX52" "hsa:11056; Q86YG1; Q8N213; Q9NVE0; Q9Y2R4; Q9Y482" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "Orexin receptor pathway; 17q12 copy number variation syndrome" "4" "0" "1.160" "1.179" "1.071" "1.128" "0.977" "1.014" "1.209" "1.237" "1.177" "256.7" "297.8" "302.7" "274.8" "289.6" "250.7" "260.2" "310.4" "317.5" "302.1" "" "" "" "" "" "" "" "" "" "" "206.2" "214.9" "240.5" "184.1" "200.3" "188.1" "182.2" "226.7" "317.5" "245.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1542485656427922063" "False" "High" "IsMasterProtein" "Q6P1K2" "Polyamine-modulated factor 1 OS=Homo sapiens OX=9606 GN=PMF1 PE=1 SV=2" "0.000" "False" "11.488" "16" "3" "5" "3" "205" "23.3" "5.49" "14.17" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03980" "100527963; 11243" "ENSG00000160783" "PMF1" "A8K0C5; hsa:100527963; hsa:11243; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6P1K2; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4597879666501405539" "False" "High" "IsMasterProtein" "Q9NX08" "COMM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=COMMD8 PE=1 SV=1" "0.000" "False" "11.485" "21" "2" "2" "2" "183" "21.1" "5.43" "9.43" "2" "" "cytosol;nucleus" "" "Pf07258" "54951" "ENSG00000169019" "COMMD8" "hsa:54951; Q8WUR4; Q9HC15; Q9NX08" "Neddylation" "" "1" "0" "0.915" "0.831" "0.999" "0.893" "0.984" "0.876" "0.873" "0.926" "0.959" "150.8" "137.9" "125.4" "150.6" "134.7" "148.3" "132.1" "131.6" "139.7" "144.6" "" "" "" "" "" "" "" "" "" "" "121.1" "99.5" "99.6" "100.9" "93.1" "111.3" "92.5" "96.1" "139.7" "117.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3246576723643333795" "False" "High" "IsMasterProtein" "Q8N668" "COMM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMMD1 PE=1 SV=1" "0.000" "False" "11.476" "7" "1" "1" "1" "190" "21.2" "6.20" "5.52" "1" "DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07258, Pf17221" "150684" "ENSG00000173163" "COMMD1" "B4DFQ4; hsa:150684; Q8N668; Q96GS0" "Neddylation" "Copper homeostasis; 1p36 copy number variation syndrome" "3" "0" "1.038" "1.024" "0.999" "1.071" "1.182" "1.209" "1.115" "1.055" "1.135" "108.0" "112.0" "110.5" "107.9" "115.6" "127.6" "130.5" "120.4" "113.9" "122.6" "" "" "" "" "" "" "" "" "" "" "86.7" "80.8" "87.8" "72.3" "79.9" "95.7" "91.4" "87.9" "113.9" "99.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1153318479582770530" "False" "High" "IsMasterProtein" "P53677" "AP-3 complex subunit mu-2 OS=Homo sapiens OX=9606 GN=AP3M2 PE=1 SV=1" "0.000" "False" "11.468" "7" "3" "3" "1" "418" "46.9" "7.56" "11.11" "3" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf00928, Pf01217" "10947" "ENSG00000070718" "AP3M2" "B2RCR0; D3DSY2; hsa:10947; P53677; Q7Z472" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311968132693307525" "False" "High" "IsMasterProtein" "P42773" "Cyclin-dependent kinase 4 inhibitor C OS=Homo sapiens OX=9606 GN=CDKN2C PE=1 SV=1" "0.000" "False" "11.465" "16" "3" "5" "3" "168" "18.1" "6.52" "15.36" "3" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12796" "1031" "ENSG00000123080" "CDKN2C" "hsa:1031; P42773; Q8TB83" "Oncogene Induced Senescence; Oxidative Stress Induced Senescence; Cyclin D associated events in G1; Senescence-Associated Secretory Phenotype (SASP)" "Cell cycle; Glioblastoma signaling pathways; Vitamin D receptor pathway; G1 to S cell cycle control" "8" "0" "1.014" "1.008" "1.085" "0.966" "1.036" "0.962" "0.893" "0.994" "1.000" "443.6" "449.9" "447.0" "481.1" "428.6" "459.7" "426.5" "396.2" "440.8" "443.8" "" "" "" "" "" "" "" "" "" "" "356.3" "324.6" "355.1" "322.3" "296.4" "344.9" "298.6" "289.3" "440.8" "360.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-317196890552299004" "False" "High" "IsMasterProtein" "Q9C0B9" "Zinc finger CCHC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZCCHC2 PE=1 SV=6" "0.000" "False" "11.457" "3" "3" "3" "3" "1178" "125.9" "7.01" "10.11" "3" "" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "54877" "ENSG00000141664" "ZCCHC2" "B2RPG6; hsa:54877; Q8N3S1; Q9C0B9; Q9NXF6" "" "" "0" "0" "1.176" "1.072" "1.001" "1.180" "1.019" "1.311" "1.030" "1.265" "1.078" "112.3" "132.1" "120.4" "112.4" "132.6" "114.4" "147.3" "115.7" "142.1" "121.1" "" "" "" "" "" "" "" "" "" "" "90.2" "95.3" "95.6" "75.3" "91.7" "85.9" "103.1" "84.5" "142.1" "98.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257643935121491465" "False" "High" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "0.000" "False" "11.434" "7" "3" "3" "3" "406" "46.9" "8.37" "10.42" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "" "2" "0" "1.037" "1.069" "1.054" "1.062" "1.063" "1.033" "1.039" "1.037" "1.064" "616.0" "638.6" "658.4" "649.0" "654.4" "655.0" "636.4" "640.0" "638.8" "655.4" "" "" "" "" "" "" "" "" "" "" "494.7" "460.8" "523.0" "434.8" "452.6" "491.4" "445.6" "467.4" "638.8" "533.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888035968268434758" "False" "High" "IsMasterProtein" "Q9Y3B2" "Exosome complex component CSL4 OS=Homo sapiens OX=9606 GN=EXOSC1 PE=1 SV=1" "0.000" "False" "11.429" "21" "3" "3" "3" "195" "21.4" "8.24" "7.53" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf10447, Pf14382" "51013" "ENSG00000171311" "EXOSC1" "B2R9B3; hsa:51013; Q5JTH3; Q9Y3B2" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "0.979" "1.065" "1.129" "1.135" "1.179" "1.041" "0.974" "0.982" "1.024" "205.6" "201.2" "218.9" "232.0" "233.3" "242.3" "214.0" "200.3" "201.9" "210.4" "" "" "" "" "" "" "" "" "" "" "165.1" "145.2" "173.9" "155.4" "161.3" "181.8" "149.8" "146.3" "201.9" "171.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4922430964326819838" "False" "High" "IsMasterProtein" "Q13686" "Nucleic acid dioxygenase ALKBH1 OS=Homo sapiens OX=9606 GN=ALKBH1 PE=1 SV=2" "0.000" "False" "11.425" "11" "3" "3" "3" "389" "43.8" "7.08" "5.66" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf13532" "8846" "ENSG00000100601" "ALKBH1" "Q13686; Q8TAU1; Q9ULA7" "" "" "0" "0" "0.966" "1.080" "0.931" "1.011" "0.844" "0.923" "0.979" "0.916" "0.961" "353.0" "341.1" "381.3" "328.6" "356.9" "297.9" "325.7" "345.5" "323.4" "339.1" "" "" "" "" "" "" "" "" "" "" "283.5" "246.1" "302.9" "220.2" "246.9" "223.5" "228.1" "252.3" "323.4" "275.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5265324397927722466" "False" "High" "IsMasterProtein" "Q6PIW4" "Fidgetin-like protein 1 OS=Homo sapiens OX=9606 GN=FIGNL1 PE=1 SV=2" "0.000" "False" "11.414" "4" "3" "3" "3" "674" "74.0" "7.85" "9.41" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004, Pf09336, Pf17862" "63979" "ENSG00000132436" "FIGNL1" "D3DVM6; hsa:63979; Q6PIW4; Q86V18; Q8ND59; Q9H8P1; Q9H917" "" "" "0" "0" "0.429" "0.453" "0.535" "0.512" "0.496" "0.499" "0.481" "0.541" "0.945" "539.3" "231.2" "244.3" "288.5" "276.2" "267.7" "269.1" "259.6" "291.5" "509.3" "" "" "" "" "" "" "" "" "" "" "433.1" "166.8" "194.1" "193.3" "191.1" "200.9" "188.4" "189.6" "291.5" "414.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-909250529717419183" "False" "High" "IsMasterProtein" "P26447" "Protein S100-A4 OS=Homo sapiens OX=9606 GN=S100A4 PE=1 SV=1" "0.000" "False" "11.397" "28" "3" "5" "3" "101" "11.7" "6.11" "16.69" "3" "signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01023" "6275" "ENSG00000196154" "S100A4" "A8K7R8; D3DV46; hsa:6275; P26447; Q6ICP8" "" "Vitamin D receptor pathway" "1" "0" "1.039" "1.036" "1.085" "1.023" "1.112" "1.024" "1.051" "1.006" "1.062" "312.0" "324.3" "323.2" "338.4" "319.1" "346.9" "319.5" "327.7" "314.0" "331.4" "" "" "" "" "" "" "" "" "" "" "250.6" "234.0" "256.8" "226.7" "220.7" "260.3" "223.7" "239.3" "314.0" "269.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7724686332336547987" "False" "High" "IsMasterProtein" "Q5JPI9" "EEF1A lysine methyltransferase 2 OS=Homo sapiens OX=9606 GN=EEF1AKMT2 PE=1 SV=2" "0.000" "False" "11.392" "5" "1" "2" "1" "291" "31.8" "6.16" "7.63" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13847" "399818" "ENSG00000203791" "EEF1AKMT2" "A8MPY7; Q5JPI9" "Protein methylation" "" "1" "0" "0.998" "0.995" "1.044" "0.971" "1.088" "0.979" "1.036" "0.951" "0.954" "93.0" "92.8" "92.5" "97.1" "90.2" "101.2" "91.0" "96.3" "88.4" "88.7" "" "" "" "" "" "" "" "" "" "" "74.7" "67.0" "73.5" "65.0" "62.4" "75.9" "63.7" "70.3" "88.4" "72.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7222165964987125403" "False" "High" "IsMasterProtein" "P36954" "DNA-directed RNA polymerase II subunit RPB9 OS=Homo sapiens OX=9606 GN=POLR2I PE=1 SV=1" "0.000" "False" "11.380" "20" "2" "3" "2" "125" "14.5" "5.14" "8.97" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf02150" "5438" "ENSG00000105258" "POLR2I" "B2R5J2; hsa:5438; P36954; Q6NW05" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.019" "1.293" "0.895" "1.014" "1.221" "1.105" "1.120" "1.143" "1.149" "141.8" "144.6" "183.4" "127.0" "143.8" "173.2" "156.8" "158.9" "162.2" "162.9" "" "" "" "" "" "" "" "" "" "" "113.9" "104.3" "145.7" "85.1" "99.4" "130.0" "109.8" "116.0" "162.2" "132.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058361017873513588" "False" "High" "IsMasterProtein" "P63173" "Large ribosomal subunit protein eL38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "0.000" "False" "11.374" "24" "2" "3" "2" "70" "8.2" "10.10" "10.14" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "16" "0" "0.853" "0.972" "0.956" "1.093" "1.239" "1.252" "1.110" "1.065" "1.081" "351.8" "300.2" "341.9" "336.1" "384.5" "435.9" "440.4" "390.5" "374.7" "380.2" "" "" "" "" "" "" "" "" "" "" "282.5" "216.6" "271.6" "225.2" "265.9" "327.1" "308.3" "285.2" "374.7" "309.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2434298641534178381" "False" "High" "IsMasterProtein" "P42336" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PIK3CA PE=1 SV=2" "0.000" "False" "11.362" "4" "4" "5" "4" "1068" "124.2" "7.23" "9.66" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5290" "ENSG00000121879" "PIK3CA" "hsa:5290; P42336; Q14CW1; Q99762" "Downstream TCR signaling; Signaling by ALK fusions and activated point mutants; Signaling by ALK; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "AMP-activated protein kinase signaling; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; IL1 and megakaryocytes in obesity; Transcriptional activation by NRF2 in response to phytochemicals; Focal adhesion; Hepatocyte growth factor receptor signaling; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Warburg effect modulated by deubiquitinating enzymes and their substrates; G13 signaling pathway; Comprehensive IL-17A signaling; Acute myeloid leukemia; IL-26 signaling pathways; Osteoarthritic chondrocyte hypertrophy; GNAQ pathways in port-wine stain; ErbB signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "140" "0" "0.873" "0.899" "1.017" "0.911" "0.937" "1.006" "0.898" "0.815" "0.966" "87.5" "76.3" "78.7" "88.9" "79.7" "81.9" "88.0" "78.6" "71.3" "84.5" "" "" "" "" "" "" "" "" "" "" "70.3" "55.1" "62.5" "59.6" "55.1" "61.5" "61.6" "57.4" "71.3" "68.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7556059928236931209" "False" "High" "IsMasterProtein" "Q86T82" "Ubiquitin carboxyl-terminal hydrolase 37 OS=Homo sapiens OX=9606 GN=USP37 PE=1 SV=2" "0.000" "False" "11.349" "3" "3" "3" "3" "979" "110.1" "6.20" "10.12" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf02809, Pf16674" "57695" "ENSG00000135913" "USP37" "A2RUQ8; B7ZM38; B7ZM41; E9PHL3; hsa:57695; Q2KHT2; Q53S10; Q7Z3A5; Q86T82; Q9HCH8" "Ub-specific processing proteases" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "2" "0" "1.153" "1.177" "1.206" "1.078" "1.051" "1.205" "1.244" "1.180" "1.171" "272.3" "314.0" "320.5" "328.3" "293.5" "286.3" "328.2" "338.7" "321.3" "318.7" "" "" "" "" "" "" "" "" "" "" "218.7" "226.6" "254.6" "219.9" "203.0" "214.8" "229.8" "247.3" "321.3" "259.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8294096591756946044" "False" "High" "IsMasterProtein" "O43739" "Cytohesin-3 OS=Homo sapiens OX=9606 GN=CYTH3 PE=1 SV=2" "0.000" "False" "11.348" "8" "3" "3" "1" "400" "46.3" "5.47" "10.22" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9265" "ENSG00000008256" "CYTH3" "A4D2N8; hsa:9265; O43739" "Intra-Golgi traffic" "Insulin signaling; 2q37 copy number variation syndrome" "3" "0" "0.953" "1.084" "0.957" "0.906" "0.795" "1.249" "1.236" "0.948" "0.966" "16.5" "15.8" "17.9" "15.8" "15.0" "13.2" "20.7" "20.4" "15.7" "16.0" "" "" "" "" "" "" "" "" "" "" "13.3" "11.4" "14.2" "10.6" "10.4" "9.9" "14.5" "14.9" "15.7" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2010666374773995606" "False" "High" "IsMasterProtein" "Q06587" "E3 ubiquitin-protein ligase RING1 OS=Homo sapiens OX=9606 GN=RING1 PE=1 SV=2" "0.000" "False" "11.327" "9" "3" "4" "3" "406" "42.4" "5.62" "13.66" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00097, Pf16207" "6015" "ENSG00000204227; ENSG00000206287; ENSG00000226788; ENSG00000228520; ENSG00000231115; ENSG00000235107" "RING1" "A8JZZ0; Q06587; Q5JP96; Q5SQW2; Q86V19" "Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "Pleural mesothelioma; Notch signaling pathway" "11" "0" "1.001" "0.952" "1.063" "1.138" "1.000" "1.165" "1.103" "1.019" "1.007" "165.2" "165.4" "157.3" "175.6" "188.1" "165.2" "192.4" "182.2" "168.4" "166.4" "" "" "" "" "" "" "" "" "" "" "132.7" "119.3" "124.9" "117.7" "130.1" "124.0" "134.7" "133.1" "168.4" "135.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4794546056511531982" "False" "High" "IsMasterProtein" "Q969Q5" "Ras-related protein Rab-24 OS=Homo sapiens OX=9606 GN=RAB24 PE=1 SV=1" "0.000" "False" "11.316" "10" "2" "3" "2" "203" "23.1" "6.23" "8.87" "2" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53917" "ENSG00000169228" "RAB24" "A0A024R7N9; hsa:53917; Q7Z4Z7; Q969Q5" "Neutrophil degranulation; RAB geranylgeranylation" "5q35 copy number variation" "3" "0" "1.450" "1.026" "1.147" "1.505" "1.018" "1.057" "0.859" "1.232" "1.359" "16.1" "23.3" "16.5" "18.4" "24.2" "16.3" "17.0" "13.8" "19.8" "21.8" "" "" "" "" "" "" "" "" "" "" "12.9" "16.8" "13.1" "12.3" "16.7" "12.3" "11.9" "10.1" "19.8" "17.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552389438880602085" "False" "High" "IsMasterProtein" "Q7L5Y1" "Mitochondrial enolase superfamily member 1 OS=Homo sapiens OX=9606 GN=ENOSF1 PE=1 SV=1" "0.000" "False" "11.298" "7" "3" "3" "3" "443" "49.8" "6.48" "9.35" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf02746, Pf13378" "55556" "ENSG00000132199" "ENOSF1" "A6NMP3; A8K9R5; B3KSL6; B3KXE4; D3DUH0; hsa:55556; Q15407; Q15594; Q15595; Q6ZS08; Q7L5Y1; Q9HAS5; Q9HAS6" "" "" "0" "0" "0.920" "0.929" "1.147" "1.102" "1.016" "1.175" "1.053" "0.945" "0.947" "250.1" "230.2" "232.3" "286.9" "275.7" "254.2" "293.8" "263.3" "236.5" "236.9" "" "" "" "" "" "" "" "" "" "" "200.9" "166.1" "184.6" "192.2" "190.7" "190.7" "205.7" "192.3" "236.5" "192.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740975055967109676" "False" "High" "IsMasterProtein" "O95926" "Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1" "0.000" "False" "11.280" "9" "2" "2" "2" "243" "28.7" "8.40" "8.44" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf08231" "25949" "ENSG00000117614" "SYF2" "hsa:25949; O95926; Q5TH73" "mRNA Splicing - Major Pathway" "" "1" "0" "1.022" "1.021" "1.129" "1.076" "1.086" "1.012" "0.943" "0.899" "0.946" "183.0" "187.0" "186.8" "206.6" "196.8" "198.7" "185.2" "172.5" "164.5" "173.1" "" "" "" "" "" "" "" "" "" "" "147.0" "135.0" "148.4" "138.4" "136.1" "149.1" "129.7" "126.0" "164.5" "140.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318017659961933117" "False" "High" "IsMasterProtein" "Q9NVA1" "Ubiquinol-cytochrome c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3" "0.000" "False" "11.270" "6" "2" "3" "2" "299" "34.6" "8.91" "10.02" "2" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "" "Pf03981" "55245" "ENSG00000101019" "UQCC1" "B1AKV5; hsa:55245; Q0VF37; Q5T348; Q5T351; Q5T353; Q86YU3; Q86YU4; Q96H66; Q9H438; Q9H452; Q9H9K8; Q9H9R5; Q9NVA1" "" "Ciliary landscape; Mitochondrial complex III assembly" "2" "0" "0.996" "0.953" "0.888" "0.965" "0.951" "1.023" "1.038" "1.023" "0.979" "358.1" "356.8" "341.4" "317.8" "345.7" "340.5" "366.2" "371.7" "366.3" "350.5" "" "" "" "" "" "" "" "" "" "" "287.6" "257.5" "271.2" "213.0" "239.1" "255.5" "256.4" "271.5" "366.3" "285.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429819292905121696" "False" "High" "IsMasterProtein" "P57077" "MAP3K7 C-terminal-like protein OS=Homo sapiens OX=9606 GN=MAP3K7CL PE=1 SV=2" "0.000" "False" "11.258" "18" "3" "3" "3" "142" "16.4" "4.89" "11.25" "3" "" "" "" "" "56911" "ENSG00000156265; ENSG00000291525" "MAP3K7CL" "D3DSE0; hsa:56911; P57077; Q8TCL9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7573385717766537595" "False" "High" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "0.000" "False" "11.251" "5" "2" "2" "2" "426" "46.0" "8.53" "8.77" "2" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "Photodynamic therapy-induced HIF-1 survival signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "5" "0" "0.998" "1.073" "1.077" "1.065" "0.964" "0.973" "1.036" "0.997" "1.060" "232.1" "231.7" "249.1" "249.9" "247.1" "223.8" "225.9" "240.5" "231.4" "246.0" "" "" "" "" "" "" "" "" "" "" "186.4" "167.2" "197.9" "167.4" "170.9" "167.9" "158.1" "175.6" "231.4" "200.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4474106479109079676" "False" "High" "IsMasterProtein" "O00422" "Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1" "0.000" "False" "11.193" "35" "5" "8" "5" "153" "17.6" "9.35" "15.95" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06487" "10284" "ENSG00000150459" "SAP18" "B2R494; hsa:10284; O00422; Q2TTR4; Q6IAW9; Q8N606; Q9UF14; X6RAL5" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway" "Hedgehog signaling pathway" "5" "0" "0.878" "0.923" "1.022" "0.956" "1.053" "1.069" "0.990" "1.046" "0.994" "631.1" "554.4" "582.8" "644.7" "603.5" "664.3" "674.8" "624.7" "660.0" "627.1" "" "" "" "" "" "" "" "" "" "" "506.9" "400.0" "462.9" "432.0" "417.4" "498.4" "472.5" "456.2" "660.0" "509.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2291665734159650582" "False" "High" "IsMasterProtein" "P62310" "U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2" "0.000" "False" "11.193" "12" "1" "3" "1" "102" "11.8" "4.70" "13.06" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27258" "ENSG00000170860" "LSM3" "hsa:27258; P62310; Q6IAH0; Q9Y4Z1" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "1.137" "0.995" "1.012" "0.939" "0.925" "1.034" "1.041" "0.946" "0.993" "406.2" "461.7" "404.0" "411.1" "381.6" "375.7" "420.0" "422.9" "384.4" "403.5" "" "" "" "" "" "" "" "" "" "" "326.3" "333.2" "320.9" "275.5" "263.9" "281.9" "294.1" "308.9" "384.4" "328.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-781498784979718201" "False" "High" "IsMasterProtein" "Q8IY22" "C-Maf-inducing protein OS=Homo sapiens OX=9606 GN=CMIP PE=1 SV=3" "0.000" "False" "11.186" "3" "2" "2" "2" "773" "86.3" "6.70" "8.01" "2" "developmental processes" "cytosol;nucleus" "" "" "80790" "ENSG00000153815" "CMIP" "hsa:80790; Q8IY22; Q9C0G9" "" "" "0" "0" "1.004" "1.038" "1.014" "0.933" "0.969" "0.885" "0.951" "0.980" "0.974" "345.0" "346.5" "358.0" "350.0" "321.9" "334.4" "305.4" "328.2" "338.3" "336.2" "" "" "" "" "" "" "" "" "" "" "277.1" "250.0" "284.4" "234.5" "222.6" "250.9" "213.8" "239.7" "338.3" "273.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5405439584537602890" "False" "High" "IsMasterProtein" "Q9BX46" "RNA-binding protein 24 OS=Homo sapiens OX=9606 GN=RBM24 PE=1 SV=1" "0.000" "False" "11.177" "15" "3" "3" "3" "236" "24.8" "8.51" "7.15" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "221662" "ENSG00000112183" "RBM24" "E9PAY4; hsa:221662; Q6QDA4; Q8N9D3; Q96NI3; Q9BX46" "" "" "0" "0" "0.933" "0.922" "0.946" "1.005" "0.992" "0.988" "0.961" "0.796" "0.918" "109.7" "102.3" "101.1" "103.8" "110.2" "108.8" "108.3" "105.4" "87.3" "100.7" "" "" "" "" "" "" "" "" "" "" "88.1" "73.8" "80.3" "69.6" "76.2" "81.6" "75.9" "77.0" "87.3" "81.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5255338936326354588" "False" "High" "IsMasterProtein" "O75448" "Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1" "0.000" "False" "11.169" "3" "3" "4" "3" "989" "110.2" "6.95" "7.01" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11277" "9862" "ENSG00000008838" "MED24" "A8K4S5; B3KMR9; hsa:9862; O75448; Q14143; Q9NNY5" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.084" "0.955" "1.093" "1.104" "0.974" "1.201" "1.194" "1.027" "1.085" "223.8" "242.7" "213.7" "244.6" "247.2" "218.0" "268.7" "267.2" "229.8" "242.8" "" "" "" "" "" "" "" "" "" "" "179.8" "175.1" "169.7" "163.9" "171.0" "163.5" "188.2" "195.2" "229.8" "197.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5203794321803300352" "False" "High" "IsMasterProtein" "Q9UKI3" "Pre-B lymphocyte protein 3 OS=Homo sapiens OX=9606 GN=VPREB3 PE=1 SV=1" "0.000" "False" "11.165" "11" "1" "5" "1" "123" "13.7" "5.36" "13.22" "1" "other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf07686" "29802" "ENSG00000128218" "VPREB3" "B2R587; hsa:29802; Q9UKI3" "Cell surface interactions at the vascular wall" "" "1" "0" "1.184" "1.206" "1.166" "1.057" "1.485" "1.289" "1.424" "1.270" "1.295" "24.9" "29.5" "30.0" "29.0" "26.3" "36.9" "32.1" "35.4" "31.6" "32.2" "" "" "" "" "" "" "" "" "" "" "20.0" "21.3" "23.8" "19.4" "18.2" "27.7" "22.4" "25.9" "31.6" "26.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225180490638560304" "False" "High" "IsMasterProtein" "P51157" "Ras-related protein Rab-28 OS=Homo sapiens OX=9606 GN=RAB28 PE=1 SV=2" "0.000" "False" "11.165" "9" "2" "2" "2" "221" "24.8" "5.97" "7.95" "2" "transport" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00071" "9364" "ENSG00000157869" "RAB28" "G8JLC5; hsa:9364; P51157; Q8IYR8; Q8NI05" "" "Ciliopathies" "1" "0" "0.991" "0.983" "1.044" "0.951" "0.931" "0.918" "0.887" "0.949" "0.961" "391.0" "387.3" "384.4" "408.2" "371.7" "364.0" "358.8" "346.9" "371.1" "375.8" "" "" "" "" "" "" "" "" "" "" "314.0" "279.5" "305.4" "273.5" "257.1" "273.1" "251.2" "253.3" "371.1" "305.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5951829502980748262" "False" "High" "IsMasterProtein" "Q92989" "Polyribonucleotide 5'-hydroxyl-kinase Clp1 OS=Homo sapiens OX=9606 GN=CLP1 PE=1 SV=1" "0.000" "False" "11.162" "9" "5" "6" "5" "425" "47.6" "6.62" "17.20" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06807, Pf16573, Pf16575" "10978" "ENSG00000172409" "CLP1" "B2R7J6; B4DTI8; hsa:10978; Q92989" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "0.981" "1.016" "0.956" "0.967" "0.932" "0.904" "0.967" "0.973" "0.977" "688.8" "675.6" "700.0" "658.7" "666.2" "641.7" "622.4" "665.9" "670.0" "673.0" "" "" "" "" "" "" "" "" "" "" "553.3" "487.5" "556.0" "441.3" "460.7" "481.4" "435.8" "486.3" "670.0" "547.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2673167889447724756" "False" "High" "IsMasterProtein" "Q8IZD4" "mRNA-decapping enzyme 1B OS=Homo sapiens OX=9606 GN=DCP1B PE=1 SV=2" "0.000" "False" "11.158" "4" "2" "2" "2" "617" "67.7" "8.56" "8.99" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "196513" "ENSG00000151065; ENSG00000284850" "DCP1B" "B4DRD1; hsa:196513; Q86XH9; Q8IZD4; Q96BP8; Q96MZ8" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.008" "0.952" "1.119" "1.006" "1.178" "1.027" "0.844" "1.054" "1.042" "51.7" "52.1" "49.2" "57.9" "52.0" "60.9" "53.1" "43.6" "54.5" "53.9" "" "" "" "" "" "" "" "" "" "" "41.5" "37.6" "39.1" "38.8" "35.9" "45.7" "37.2" "31.9" "54.5" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4139292263047059724" "False" "High" "IsMasterProtein" "Q96L50" "Leucine-rich repeat protein 1 OS=Homo sapiens OX=9606 GN=LRR1 PE=1 SV=2" "0.000" "False" "11.140" "5" "2" "4" "2" "414" "46.7" "9.09" "12.40" "2" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus" "" "Pf00560, Pf12799" "122769" "ENSG00000165501" "LRR1" "A5D6X3; B4DDE0; hsa:122769; Q52M24; Q86SZ1; Q8N6H9; Q96L50" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.048" "0.978" "1.081" "1.077" "0.950" "1.135" "1.169" "1.102" "1.042" "392.2" "411.0" "383.6" "423.8" "422.4" "372.6" "445.3" "458.3" "432.1" "408.8" "" "" "" "" "" "" "" "" "" "" "315.0" "296.5" "304.7" "283.9" "292.1" "279.5" "311.8" "334.7" "432.1" "332.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2885282100623052741" "False" "High" "IsMasterProtein" "Q8TAV0" "Protein FAM76A OS=Homo sapiens OX=9606 GN=FAM76A PE=1 SV=1" "0.000" "False" "11.132" "12" "4" "5" "4" "307" "35.0" "9.19" "13.01" "4" "" "nucleus" "" "Pf16046" "199870" "ENSG00000009780" "FAM76A" "B4DWT3; hsa:199870; O95565; O95566; Q8N7J5; Q8TAV0" "" "" "0" "0" "1.004" "0.973" "1.070" "1.034" "1.127" "1.040" "1.072" "1.067" "1.073" "369.0" "370.5" "359.0" "394.8" "381.4" "415.9" "383.6" "395.6" "393.8" "396.1" "" "" "" "" "" "" "" "" "" "" "296.4" "267.3" "285.2" "264.5" "263.8" "312.1" "268.6" "288.9" "393.8" "322.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4513402261466963400" "False" "High" "IsMasterProtein" "O75582" "Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens OX=9606 GN=RPS6KA5 PE=1 SV=1" "0.000" "False" "11.125" "4" "4" "4" "3" "802" "89.8" "7.11" "10.50" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "9252" "ENSG00000100784" "RPS6KA5" "B7Z2Y5; hsa:9252; O75582; O95316; Q96AF7" "Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "22" "0" "1.264" "0.925" "1.166" "1.038" "1.112" "0.948" "1.034" "1.009" "1.182" "43.1" "54.5" "39.9" "50.3" "44.8" "48.0" "40.9" "44.6" "43.5" "51.0" "" "" "" "" "" "" "" "" "" "" "34.6" "39.3" "31.7" "33.7" "31.0" "36.0" "28.6" "32.6" "43.5" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3102131592095934236" "False" "High" "IsMasterProtein" "Q969G6" "Riboflavin kinase OS=Homo sapiens OX=9606 GN=RFK PE=1 SV=2" "0.000" "False" "11.097" "19" "3" "4" "3" "155" "17.6" "8.13" "14.18" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01687" "55312" "ENSG00000135002" "RFK" "hsa:55312; Q5JSG9; Q969G6; Q9NUT7" "Vitamin B2 (riboflavin) metabolism" "Selenium micronutrient network; Folate metabolism; TNF-alpha signaling pathway" "4" "0" "0.884" "0.921" "0.952" "0.915" "0.880" "0.913" "0.880" "0.915" "0.917" "488.8" "432.1" "449.9" "465.2" "447.4" "430.2" "446.2" "430.2" "447.3" "448.1" "" "" "" "" "" "" "" "" "" "" "392.6" "311.8" "357.4" "311.7" "309.4" "322.8" "312.4" "314.2" "447.3" "364.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8652321965736247269" "False" "High" "IsMasterProtein" "Q8TCA0" "Leucine-rich repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=LRRC20 PE=1 SV=1" "0.000" "False" "11.083" "15" "2" "2" "2" "184" "20.5" "6.55" "6.92" "2" "" "" "" "Pf13855" "55222" "ENSG00000172731" "LRRC20" "hsa:55222; Q5T6D4; Q5T6D6; Q8TCA0; Q9NVA6; Q9NVG3" "" "" "0" "0" "1.185" "1.344" "1.269" "1.419" "1.177" "1.104" "1.315" "1.216" "1.125" "32.7" "38.7" "43.9" "41.5" "46.4" "38.5" "36.1" "43.0" "39.7" "36.7" "" "" "" "" "" "" "" "" "" "" "26.2" "27.9" "34.9" "27.8" "32.1" "28.8" "25.3" "31.4" "39.7" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-203379576220599078" "False" "High" "IsMasterProtein" "Q13158" "FAS-associated death domain protein OS=Homo sapiens OX=9606 GN=FADD PE=1 SV=1" "0.000" "False" "11.062" "15" "2" "2" "2" "208" "23.3" "5.69" "9.22" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf01335" "8772" "ENSG00000168040" "FADD" "hsa:8772; Q13158; Q14866; Q6IBR4" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway" "33" "0" "1.046" "1.006" "1.039" "0.964" "0.923" "1.017" "0.880" "0.953" "0.908" "133.2" "139.4" "134.0" "138.5" "128.5" "122.9" "135.5" "117.3" "127.0" "121.0" "" "" "" "" "" "" "" "" "" "" "107.0" "100.6" "106.5" "92.8" "88.9" "92.2" "94.9" "85.6" "127.0" "98.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7703205907594076097" "False" "High" "IsMasterProtein" "Q12982" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=BNIP2 PE=1 SV=1" "0.000" "False" "11.043" "6" "2" "2" "2" "314" "36.0" "4.81" "7.98" "2" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12496, Pf13716" "663" "ENSG00000140299" "BNIP2" "B4DS94; hsa:663; Q12982" "Myogenesis" "Acute viral myocarditis" "2" "0" "0.991" "0.876" "0.858" "0.900" "0.802" "0.693" "0.814" "0.839" "0.837" "220.2" "218.2" "193.0" "189.0" "198.1" "176.6" "152.6" "179.3" "184.7" "184.2" "" "" "" "" "" "" "" "" "" "" "176.9" "157.4" "153.3" "126.6" "137.0" "132.5" "106.8" "131.0" "184.7" "149.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5765405585808973538" "False" "High" "IsMasterProtein" "P32780" "General transcription factor IIH subunit 1 OS=Homo sapiens OX=9606 GN=GTF2H1 PE=1 SV=1" "0.000" "False" "11.037" "6" "3" "3" "3" "548" "62.0" "8.66" "7.41" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf03909, Pf08567" "2965" "ENSG00000110768; ENSG00000288114" "GTF2H1" "B3KXE0; D3DQY2; hsa:2965; P32780; Q6I9Y7; Q9H5K5; Q9NQD9" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "33" "0" "1.051" "0.974" "1.177" "1.065" "1.088" "1.144" "1.126" "1.096" "1.216" "94.9" "99.7" "92.4" "111.7" "101.1" "103.3" "108.5" "106.9" "104.0" "115.4" "" "" "" "" "" "" "" "" "" "" "76.2" "72.0" "73.4" "74.8" "69.9" "77.5" "76.0" "78.0" "104.0" "93.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1082810895474363705" "False" "High" "IsMasterProtein" "P06746" "DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3" "0.000" "False" "11.026" "9" "3" "5" "3" "335" "38.2" "8.95" "13.30" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf10391, Pf14716, Pf14791, Pf14792" "5423" "ENSG00000070501" "POLB" "B2RC78; hsa:5423; P06746; Q3KP48; Q6FI34" "Ub-specific processing proteases; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "Male infertility; Base excision repair; DNA repair pathways, full network" "10" "0" "0.893" "1.260" "1.281" "0.999" "1.143" "1.505" "1.413" "1.227" "1.110" "21.3" "19.0" "26.8" "27.3" "21.3" "24.3" "32.1" "30.1" "26.1" "23.6" "" "" "" "" "" "" "" "" "" "" "17.1" "13.7" "21.3" "18.3" "14.7" "18.3" "22.4" "22.0" "26.1" "19.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6376451565471680516" "False" "High" "IsMasterProtein" "Q6P4I2" "WD repeat-containing protein 73 OS=Homo sapiens OX=9606 GN=WDR73 PE=1 SV=1" "0.000" "False" "11.019" "8" "3" "3" "3" "378" "41.7" "5.78" "8.78" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "" "" "84942" "ENSG00000177082; ENSG00000291629" "WDR73" "hsa:84942; Q6P4I2; Q96JZ1; Q9P0B7" "" "Nephrotic syndrome; 15q25 copy number variation" "2" "0" "0.994" "1.143" "0.943" "1.089" "1.070" "0.970" "1.082" "1.065" "1.131" "119.2" "118.5" "136.3" "112.4" "129.9" "127.5" "115.6" "128.9" "127.0" "134.8" "" "" "" "" "" "" "" "" "" "" "95.7" "85.5" "108.2" "75.3" "89.8" "95.7" "80.9" "94.1" "127.0" "109.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494037614751494800" "False" "High" "IsMasterProtein" "O94900" "Thymocyte selection-associated high mobility group box protein TOX OS=Homo sapiens OX=9606 GN=TOX PE=1 SV=3" "0.000" "False" "11.000" "5" "2" "2" "2" "526" "57.5" "7.33" "7.48" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00505" "9760" "ENSG00000198846" "TOX" "hsa:9760; O94900; Q96AV5" "" "Mesodermal commitment pathway; Development and heterogeneity of the ILC family; Orexin receptor pathway" "3" "0" "0.984" "1.025" "0.895" "0.958" "1.016" "0.996" "0.947" "0.965" "0.946" "191.5" "188.5" "196.3" "171.4" "183.4" "194.6" "190.7" "181.4" "184.8" "181.2" "" "" "" "" "" "" "" "" "" "" "153.8" "136.0" "156.0" "114.8" "126.9" "146.0" "133.5" "132.5" "184.8" "147.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1998394200407490675" "False" "High" "IsMasterProtein" "Q8WUA4" "General transcription factor 3C polypeptide 2 OS=Homo sapiens OX=9606 GN=GTF3C2 PE=1 SV=2" "0.000" "False" "10.982" "5" "3" "3" "3" "911" "100.6" "7.31" "8.39" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00400" "2976" "ENSG00000115207" "GTF3C2" "D6W557; hsa:2976; Q16632; Q8WUA4; Q9BWI7" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "0.875" "1.005" "1.184" "1.018" "0.949" "0.978" "0.956" "1.008" "1.058" "127.7" "111.7" "128.3" "151.1" "129.9" "121.2" "124.9" "122.1" "128.6" "135.0" "" "" "" "" "" "" "" "" "" "" "102.5" "80.6" "101.9" "101.3" "89.9" "90.9" "87.4" "89.1" "128.6" "109.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155133754937223753" "False" "High" "IsMasterProtein" "O43402" "ER membrane protein complex subunit 8 OS=Homo sapiens OX=9606 GN=EMC8 PE=1 SV=1" "0.000" "False" "10.964" "12" "2" "2" "2" "210" "23.8" "6.40" "8.57" "2" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf03665" "10328" "ENSG00000131148" "EMC8" "C9JB21; hsa:10328; O43402" "" "" "0" "0" "1.044" "0.987" "1.111" "1.145" "1.045" "1.030" "1.042" "1.038" "1.029" "216.4" "226.0" "213.5" "240.4" "247.7" "226.2" "222.9" "225.6" "224.6" "222.8" "" "" "" "" "" "" "" "" "" "" "173.8" "163.0" "169.6" "161.1" "171.3" "169.8" "156.1" "164.8" "224.6" "181.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9088787272925242729" "False" "High" "IsMasterProtein" "Q9C0D3" "Protein zyg-11 homolog B OS=Homo sapiens OX=9606 GN=ZYG11B PE=1 SV=2" "0.000" "False" "10.959" "4" "2" "2" "2" "744" "83.9" "6.86" "7.98" "2" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "79699" "ENSG00000162378" "ZYG11B" "hsa:79699; Q8N2X3; Q9C0D3; Q9H8L8" "" "Ciliary landscape; Hijack of ubiquitination by SARS-CoV-2" "2" "0" "1.029" "0.960" "1.178" "1.329" "1.230" "1.028" "1.055" "1.003" "1.032" "177.4" "182.6" "170.3" "209.0" "235.7" "218.2" "182.4" "187.1" "177.8" "183.1" "" "" "" "" "" "" "" "" "" "" "142.5" "131.7" "135.3" "140.0" "163.0" "163.7" "127.7" "136.6" "177.8" "148.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249380285139605434" "False" "High" "IsMasterProtein" "Q96CB9" "5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2" "0.000" "False" "10.949" "8" "3" "3" "3" "384" "43.1" "8.18" "9.82" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01189" "387338" "ENSG00000117481" "NSUN4" "A8K6S6; B3KQ50; B4DHA4; hsa:387338; Q5TDF7; Q96AN8; Q96CB9; Q9HAJ8" "rRNA modification in the mitochondrion" "" "1" "0" "1.022" "0.931" "0.869" "0.933" "1.015" "0.814" "0.962" "0.892" "1.102" "105.4" "107.8" "98.2" "91.6" "98.4" "107.0" "85.8" "101.4" "94.0" "116.2" "" "" "" "" "" "" "" "" "" "" "84.7" "77.8" "78.0" "61.4" "68.1" "80.3" "60.1" "74.1" "94.0" "94.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "587629030482776779" "False" "High" "IsMasterProtein" "Q5VZM2" "Ras-related GTP-binding protein B OS=Homo sapiens OX=9606 GN=RRAGB PE=1 SV=1" "0.000" "False" "10.934" "8" "3" "4" "3" "374" "43.2" "6.21" "11.15" "3" "stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "10325" "ENSG00000083750" "RRAGB" "A8K042; hsa:10325; Q15348; Q5VZM2; Q8N3T0" "TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling" "Target of rapamycin signaling; 2q37 copy number variation syndrome" "9" "0" "1.046" "1.068" "1.074" "1.171" "1.010" "1.141" "1.168" "0.979" "1.067" "203.2" "212.6" "217.1" "218.2" "237.9" "205.3" "231.9" "237.4" "198.9" "216.9" "" "" "" "" "" "" "" "" "" "" "163.2" "153.4" "172.5" "146.2" "164.5" "154.0" "162.3" "173.4" "198.9" "176.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2073188909526316483" "False" "High" "IsMasterProtein" "Q96RJ3" "Tumor necrosis factor receptor superfamily member 13C OS=Homo sapiens OX=9606 GN=TNFRSF13C PE=1 SV=1" "0.000" "False" "10.930" "7" "1" "2" "1" "184" "18.9" "8.21" "7.93" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf09256" "115650" "ENSG00000159958" "TNFRSF13C" "hsa:115650; Q96RJ3" "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" "" "2" "0" "0.998" "0.969" "0.898" "0.744" "1.020" "1.012" "0.841" "0.939" "0.897" "149.5" "149.2" "144.9" "134.2" "111.2" "152.5" "151.3" "125.7" "140.4" "134.0" "" "" "" "" "" "" "" "" "" "" "120.1" "107.7" "115.1" "89.9" "76.9" "114.4" "106.0" "91.8" "140.4" "109.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4446297038364687966" "False" "High" "IsMasterProtein" "Q9NPA8" "Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1" "0.000" "False" "10.926" "25" "2" "2" "2" "101" "11.5" "9.33" "8.29" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10163" "56943" "ENSG00000120533" "ENY2" "B2RE52; G3V117; hsa:56943; Q9NPA8" "HATs acetylate histones" "" "1" "0" "0.891" "0.953" "1.092" "1.034" "0.989" "0.988" "0.916" "0.883" "0.901" "49.4" "44.1" "47.1" "54.0" "51.1" "48.9" "48.8" "45.3" "43.7" "44.6" "" "" "" "" "" "" "" "" "" "" "39.7" "31.8" "37.4" "36.2" "35.3" "36.7" "34.2" "33.1" "43.7" "36.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530095289376032453" "False" "High" "IsMasterProtein" "Q9HBH1" "Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1" "0.000" "False" "10.912" "5" "1" "2" "1" "243" "27.0" "9.16" "7.29" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01327" "64146" "ENSG00000258429" "PDF" "hsa:64146; Q8WUN6; Q9HBH1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197761236226766200" "False" "High" "IsMasterProtein" "Q9H3L0" "Cobalamin trafficking protein CblD OS=Homo sapiens OX=9606 GN=MMADHC PE=1 SV=2" "0.000" "False" "10.905" "9" "2" "2" "2" "296" "32.9" "5.29" "8.37" "2" "other metabolic processes" "cytosol;mitochondrion;other cell component" "" "Pf10229" "27249" "ENSG00000168288" "MMADHC" "B2R895; D3DP91; hsa:27249; O95891; Q9H3L0" "Cobalamin (Cbl) metabolism; Defective MMADHC causes MMAHCD" "" "2" "0" "0.997" "1.087" "1.128" "1.068" "1.123" "1.020" "1.016" "1.059" "1.006" "126.1" "125.7" "137.0" "142.2" "134.6" "141.6" "128.6" "128.1" "133.5" "126.9" "" "" "" "" "" "" "" "" "" "" "101.3" "90.7" "108.8" "95.3" "93.1" "106.3" "90.0" "93.6" "133.5" "103.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7398915680383575894" "False" "High" "IsMasterProtein" "Q5BKX5" "Actin maturation protease OS=Homo sapiens OX=9606 GN=ACTMAP PE=1 SV=2" "0.000" "False" "10.893" "13" "3" "3" "3" "351" "37.8" "7.47" "8.77" "3" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf21646" "284325" "ENSG00000188493" "ACTMAP" "A8MSZ5; B4DNU7; hsa:284325; Q5BKX5" "" "" "0" "0" "0.990" "0.878" "0.939" "0.985" "0.907" "0.929" "0.964" "0.894" "0.904" "173.4" "171.6" "152.2" "162.8" "170.8" "157.2" "161.0" "167.1" "154.9" "156.7" "" "" "" "" "" "" "" "" "" "" "139.2" "123.9" "120.9" "109.1" "118.1" "118.0" "112.7" "122.1" "154.9" "127.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381937792581256012" "False" "High" "IsMasterProtein" "Q9UKW4" "Guanine nucleotide exchange factor VAV3 OS=Homo sapiens OX=9606 GN=VAV3 PE=1 SV=1" "0.000" "False" "10.881" "4" "4" "4" "2" "847" "97.7" "7.05" "10.88" "4" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00130, Pf00169, Pf00307, Pf00621, Pf07653" "10451" "ENSG00000134215" "VAV3" "B1AMM0; B1APV5; B4E232; B7ZLR1; E9PQ97; hsa:10451; O60498; O95230; Q9UKW4; Q9Y5X8" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; FCERI mediated MAPK activation; RAC1 GTPase cycle; RAC2 GTPase cycle; FCERI mediated Ca+2 mobilization; RHOA GTPase cycle; CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; GPVI-mediated activation cascade; DAP12 signaling; EPH-ephrin mediated repulsion of cells; Azathioprine ADME; VEGFR2 mediated vascular permeability" "Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; T-cell receptor signaling pathway" "26" "0" "0.957" "0.826" "1.146" "1.114" "1.085" "0.847" "0.974" "0.931" "0.960" "111.5" "106.7" "92.1" "127.8" "124.2" "121.0" "94.5" "108.6" "103.8" "107.0" "" "" "" "" "" "" "" "" "" "" "89.6" "77.0" "73.2" "85.6" "85.9" "90.8" "66.1" "79.3" "103.8" "87.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8490301965517194890" "False" "High" "IsMasterProtein" "Q9Y5P8" "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens OX=9606 GN=PPP2R3B PE=1 SV=2" "0.000" "False" "10.872" "7" "5" "5" "5" "575" "65.0" "5.14" "14.40" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499, Pf17958, Pf21161" "28227" "ENSG00000167393; ENSG00000292327" "PPP2R3B" "hsa:28227; Q6P4G9; Q7RTT1; Q96H01; Q9Y5P8" "Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Inhibition of replication initiation of damaged DNA by RB1/E2F1" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "6" "0" "0.970" "0.977" "0.996" "0.982" "0.943" "0.889" "0.958" "0.987" "0.968" "798.6" "774.3" "780.5" "795.1" "784.0" "752.9" "709.7" "764.9" "788.1" "772.9" "" "" "" "" "" "" "" "" "" "" "641.4" "558.7" "620.0" "532.7" "542.2" "564.9" "496.9" "558.6" "788.1" "628.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4178938987355296714" "False" "High" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "0.000" "False" "10.867" "30" "4" "6" "4" "80" "9.1" "9.58" "16.47" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "1.246" "1.039" "1.174" "1.296" "1.241" "1.231" "1.174" "1.260" "1.157" "648.1" "807.4" "673.4" "760.9" "840.3" "804.4" "797.7" "760.6" "816.8" "750.0" "" "" "" "" "" "" "" "" "" "" "520.6" "582.6" "534.9" "509.8" "581.1" "603.5" "558.5" "555.5" "816.8" "609.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4718065310323386899" "False" "High" "IsMasterProtein" "Q5VSL9" "Striatin-interacting protein 1 OS=Homo sapiens OX=9606 GN=STRIP1 PE=1 SV=1" "0.000" "False" "10.856" "6" "3" "3" "3" "837" "95.5" "6.29" "7.52" "3" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf07923, Pf11882" "85369" "ENSG00000143093" "STRIP1" "hsa:85369; Q0V925; Q5VSL8; Q5VSL9; Q658K2; Q6ZV31; Q8N598; Q96SN2; Q9C0A2" "" "" "0" "0" "0.963" "1.057" "1.054" "1.061" "1.053" "1.097" "1.053" "1.113" "1.052" "350.9" "337.8" "370.9" "369.7" "372.1" "369.3" "385.1" "369.6" "390.5" "369.3" "" "" "" "" "" "" "" "" "" "" "281.8" "243.7" "294.6" "247.7" "257.4" "277.1" "269.6" "269.9" "390.5" "300.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3652671627369165893" "False" "High" "IsMasterProtein" "Q9HBM1" "Kinetochore protein Spc25 OS=Homo sapiens OX=9606 GN=SPC25 PE=1 SV=1" "0.000" "False" "10.844" "16" "4" "4" "4" "224" "26.1" "8.00" "12.90" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08234" "57405" "ENSG00000152253; ENSG00000277909" "SPC25" "A8K4X8; D3DPC0; hsa:57405; Q9HBM1" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.994" "1.022" "0.997" "0.903" "1.054" "0.904" "0.894" "1.016" "1.003" "642.0" "638.0" "655.9" "640.2" "579.6" "676.5" "580.1" "574.0" "652.0" "643.9" "" "" "" "" "" "" "" "" "" "" "515.6" "460.4" "521.0" "428.9" "400.8" "507.5" "406.1" "419.2" "652.0" "523.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3680816115405291805" "False" "High" "IsMasterProtein" "Q13608" "Peroxisomal ATPase PEX6 OS=Homo sapiens OX=9606 GN=PEX6 PE=1 SV=2" "0.000" "False" "10.844" "4" "2" "2" "2" "980" "104.0" "6.34" "7.06" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00004" "5190" "ENSG00000124587" "PEX6" "hsa:5190; Q13608; Q5T8W1; Q8WYQ0; Q8WYQ1; Q8WYQ2; Q99476" "Peroxisomal protein import" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7640891103846222335" "False" "High" "IsMasterProtein" "O94819" "Kelch repeat and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=KBTBD11 PE=1 SV=1" "0.000" "False" "10.841" "4" "1" "1" "1" "623" "65.7" "6.07" "5.75" "1" "" "" "" "Pf00651, Pf01344" "9920" "ENSG00000176595; ENSG00000273645" "KBTBD11" "hsa:9920; O94819; Q3L1I0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004188409903141881" "False" "High" "IsMasterProtein" "P52758" "2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1" "0.000" "False" "10.837" "20" "2" "2" "2" "137" "14.5" "8.68" "9.06" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01042" "10247" "ENSG00000132541" "RIDA" "hsa:10247; P52758; Q6FHU9; Q6IBG0" "Threonine catabolism" "" "1" "0" "1.002" "1.015" "0.882" "0.983" "0.994" "0.905" "0.918" "1.030" "1.022" "268.3" "269.0" "272.3" "236.6" "263.7" "266.8" "242.9" "246.3" "276.4" "274.1" "" "" "" "" "" "" "" "" "" "" "215.5" "194.1" "216.3" "158.5" "182.4" "200.1" "170.0" "179.9" "276.4" "222.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3950704505580312253" "False" "High" "IsMasterProtein" "Q9BVI4" "Nucleolar complex protein 4 homolog OS=Homo sapiens OX=9606 GN=NOC4L PE=1 SV=1" "0.000" "False" "10.835" "6" "3" "4" "3" "516" "58.4" "7.49" "14.03" "3" "RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus;other cell component" "" "Pf03914" "79050" "ENSG00000184967; ENSG00000288146" "NOC4L" "hsa:79050; Q8N2S5; Q96I14; Q9BVI4" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.182" "0.983" "1.064" "1.086" "0.976" "1.005" "1.059" "1.041" "1.036" "639.6" "755.8" "628.8" "680.4" "694.8" "624.2" "642.9" "677.5" "665.8" "662.3" "" "" "" "" "" "" "" "" "" "" "513.7" "545.4" "499.5" "455.9" "480.5" "468.3" "450.1" "494.8" "665.8" "538.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177131133338512997" "False" "High" "IsMasterProtein" "Q8IXM3" "Large ribosomal subunit protein mL41 OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" "0.000" "False" "10.827" "24" "3" "3" "3" "137" "15.4" "9.57" "9.53" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09809" "64975" "ENSG00000182154" "MRPL41" "hsa:64975; Q8IXM3; Q96Q49" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.069" "1.063" "1.159" "1.231" "1.186" "1.333" "1.413" "1.221" "1.167" "235.1" "251.3" "249.9" "272.4" "289.4" "278.8" "313.4" "332.2" "287.0" "274.4" "" "" "" "" "" "" "" "" "" "" "188.8" "181.3" "198.5" "182.5" "200.1" "209.2" "219.4" "242.6" "287.0" "223.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8635487615117841616" "False" "High" "IsMasterProtein" "Q7Z3E2" "Coiled-coil domain-containing protein 186 OS=Homo sapiens OX=9606 GN=CCDC186 PE=1 SV=2" "0.000" "False" "10.808" "5" "5" "5" "5" "898" "103.6" "6.27" "2.92" "5" "cell-cell signaling;transport;other biological processes" "ER/Golgi" "other molecular function" "" "55088" "ENSG00000165813" "CCDC186" "hsa:55088; Q2M2V6; Q3ZB81; Q6NS91; Q7RTP1; Q7Z3E2; Q8N117; Q8N3G3; Q8N6C2; Q9NWA3" "" "" "0" "0" "0.897" "1.018" "1.092" "1.110" "0.928" "1.078" "1.082" "1.107" "1.268" "94.0" "84.3" "95.7" "102.7" "104.4" "87.2" "101.4" "101.7" "104.0" "119.2" "" "" "" "" "" "" "" "" "" "" "75.5" "60.8" "76.0" "68.8" "72.2" "65.4" "71.0" "74.2" "104.0" "96.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3605806557374244366" "False" "High" "IsMasterProtein" "Q99766" "ATP synthase subunit s, mitochondrial OS=Homo sapiens OX=9606 GN=DMAC2L PE=1 SV=4" "0.000" "False" "10.800" "17" "3" "3" "3" "200" "23.2" "7.90" "10.12" "3" "other metabolic processes;transport" "other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "" "27109" "ENSG00000125375" "DMAC2L" "A0A2R8YDJ1; A0A5K1VW60; A8K1U3; D9N156; hsa:27109; Q8WWX3; Q96F77; Q99766" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7864399280568064191" "False" "High" "IsMasterProtein" "Q9BT23" "LIM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LIMD2 PE=1 SV=1" "0.000" "False" "10.773" "13" "2" "3" "2" "127" "14.1" "9.03" "9.69" "2" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "80774" "ENSG00000136490" "LIMD2" "D3DU16; hsa:80774; Q96S91; Q9BT23" "" "" "0" "0" "1.066" "1.155" "1.090" "0.884" "1.151" "0.984" "0.875" "1.038" "1.004" "348.9" "371.9" "403.1" "380.2" "308.3" "401.7" "343.2" "305.2" "362.1" "350.4" "" "" "" "" "" "" "" "" "" "" "280.2" "268.4" "320.2" "254.8" "213.2" "301.4" "240.3" "222.9" "362.1" "284.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2282593962912776213" "False" "High" "IsMasterProtein" "Q15853" "Upstream stimulatory factor 2 OS=Homo sapiens OX=9606 GN=USF2 PE=1 SV=1" "0.000" "False" "10.768" "9" "3" "6" "2" "346" "36.9" "5.10" "13.48" "3" "transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7392" "ENSG00000105698" "USF2" "hsa:7392; O00671; O00709; Q05750; Q07952; Q15851; Q15852; Q15853; Q6FI33; Q6YI47" "Estrogen-dependent gene expression" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "2" "0" "0.898" "0.947" "0.827" "1.060" "0.929" "0.910" "0.784" "0.934" "1.127" "65.5" "58.8" "62.0" "54.2" "69.4" "60.9" "59.6" "51.4" "61.2" "73.8" "" "" "" "" "" "" "" "" "" "" "52.6" "42.5" "49.3" "36.3" "48.0" "45.7" "41.7" "37.5" "61.2" "60.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3610986345004973856" "False" "High" "IsMasterProtein" "P82664" "Small ribosomal subunit protein uS10m OS=Homo sapiens OX=9606 GN=MRPS10 PE=1 SV=2" "0.000" "False" "10.764" "5" "1" "2" "1" "201" "23.0" "8.00" "8.42" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "55173" "ENSG00000048544" "MRPS10" "B2RE89; hsa:55173; P82664; Q9H3E5; Q9NVR3" "Mitochondrial translation elongation; Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation termination" "" "4" "0" "1.011" "1.056" "0.974" "0.995" "0.935" "0.933" "0.933" "1.024" "0.999" "416.2" "420.9" "439.7" "405.2" "414.0" "389.1" "388.2" "388.3" "426.1" "415.7" "" "" "" "" "" "" "" "" "" "" "334.3" "303.7" "349.3" "271.5" "286.3" "292.0" "271.8" "283.6" "426.1" "338.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703778072310238355" "False" "High" "IsMasterProtein" "Q9Y6I3" "Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2" "0.000" "False" "10.755" "7" "4" "4" "4" "576" "60.3" "4.83" "11.40" "4" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01417" "29924" "ENSG00000063245" "EPN1" "hsa:29924; Q86ST3; Q9HA18; Q9Y6I3" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "5" "0" "0.956" "0.800" "0.899" "0.807" "0.830" "0.767" "0.724" "0.917" "0.866" "358.5" "342.6" "287.0" "322.3" "289.2" "297.6" "275.1" "259.7" "328.8" "310.5" "" "" "" "" "" "" "" "" "" "" "288.0" "247.2" "228.0" "215.9" "200.0" "223.3" "192.6" "189.7" "328.8" "252.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6534494641521229151" "False" "High" "IsMasterProtein" "Q9H8M2" "Bromodomain-containing protein 9 OS=Homo sapiens OX=9606 GN=BRD9 PE=1 SV=2" "0.000" "False" "10.754" "4" "1" "1" "1" "597" "67.0" "6.19" "6.47" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf12024" "65980" "ENSG00000028310" "BRD9" "A6NFY8; B4DMQ2; B4DR93; hsa:65980; Q2XUS1; Q6UWU9; Q8IUS4; Q9H5Q5; Q9H7R9; Q9H8M2" "" "" "0" "0" "1.231" "1.287" "1.287" "1.332" "1.007" "1.161" "1.160" "1.110" "1.092" "40.0" "49.2" "51.4" "51.4" "53.2" "40.2" "46.4" "46.3" "44.4" "43.6" "" "" "" "" "" "" "" "" "" "" "32.1" "35.5" "40.9" "34.4" "36.8" "30.2" "32.5" "33.8" "44.4" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8671747278693627629" "False" "High" "IsMasterProtein" "Q13554" "Calcium/calmodulin-dependent protein kinase type II subunit beta OS=Homo sapiens OX=9606 GN=CAMK2B PE=1 SV=3" "0.000" "False" "10.748" "6" "3" "8" "1" "666" "72.6" "7.27" "19.54" "3" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08332" "816" "ENSG00000058404" "CAMK2B" "A4D2K0; A4D2K1; A4D2K2; A4D2K3; A4D2K4; A4D2K5; A4D2K6; hsa:816; O95437; O95438; O95599; Q13554; Q9UGH7; Q9UGH8; Q9UGH9; Q9UNX0; Q9UNX7; Q9UP00; Q9Y5N4; Q9Y6F4" "Regulation of MECP2 expression and activity; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "Primary focal segmental glomerulosclerosis (FSGS); Myometrial relaxation and contraction pathways; Serotonin and anxiety; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; GDNF signaling; Hippocampal synaptogenesis and neurogenesis; Calcium regulation in cardiac cells; ErbB signaling pathway" "35" "0" "1.385" "1.186" "1.883" "1.428" "1.201" "1.439" "1.152" "1.251" "1.338" "48.2" "66.7" "57.1" "90.7" "68.8" "57.8" "69.3" "55.5" "60.2" "64.4" "" "" "" "" "" "" "" "" "" "" "38.7" "48.1" "45.4" "60.8" "47.6" "43.4" "48.5" "40.5" "60.2" "52.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2965457832063428151" "False" "High" "IsMasterProtein" "A8MW92" "PHD finger protein 20-like protein 1 OS=Homo sapiens OX=9606 GN=PHF20L1 PE=1 SV=2" "0.000" "False" "10.744" "4" "5" "5" "5" "1017" "114.9" "6.83" "12.86" "5" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf16660, Pf18104, Pf20826" "51105" "ENSG00000129292" "PHF20L1" "A8MW92; A8MZC9; hsa:51105; Q86U89; Q86W43; Q96BT0; Q9H702; Q9HBK3; Q9NYR3; Q9Y381" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "0.983" "0.925" "0.959" "0.971" "0.971" "0.915" "0.916" "0.985" "1.003" "379.6" "373.1" "351.2" "363.9" "368.6" "368.4" "347.3" "347.6" "374.1" "380.9" "" "" "" "" "" "" "" "" "" "" "304.9" "269.2" "279.0" "243.8" "255.0" "276.4" "243.2" "253.9" "374.1" "309.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912099457443708123" "False" "High" "IsMasterProtein" "O43913" "Origin recognition complex subunit 5 OS=Homo sapiens OX=9606 GN=ORC5 PE=1 SV=1" "0.000" "False" "10.725" "9" "4" "4" "4" "435" "50.3" "7.74" "12.76" "4" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13191, Pf14630, Pf21639" "5001" "ENSG00000164815" "ORC5" "A4D0P8; hsa:5001; O43913; O60590; O95268" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "1.021" "1.105" "1.080" "1.044" "1.071" "1.046" "0.920" "1.049" "1.079" "331.4" "338.5" "366.2" "357.9" "346.1" "355.0" "346.6" "305.1" "347.5" "357.5" "" "" "" "" "" "" "" "" "" "" "266.2" "244.2" "290.9" "239.8" "239.3" "266.3" "242.7" "222.8" "347.5" "290.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6924656061698190740" "False" "High" "IsMasterProtein" "Cont_Q2UVX4" "Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2" "0.000" "True" "10.705" "2" "2" "2" "2" "1661" "187.1" "6.84" "6.69" "2" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17790, Pf17791, Pf21308, Pf21406" "280677" "ENSBTAG00000017280" "C3" "bta:280677; Q2KIZ4; Q2UVX4" "Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5" "Complement and coagulation cascades; Complement activation, classical pathway" "11" "0" "1.172" "0.978" "1.310" "1.086" "0.897" "1.379" "0.946" "1.064" "1.133" "25.8" "30.3" "25.3" "33.8" "28.1" "23.2" "35.6" "24.5" "27.5" "29.3" "" "" "" "" "" "" "" "" "" "" "20.8" "21.9" "20.1" "22.7" "19.4" "17.4" "24.9" "17.9" "27.5" "23.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3898709646125856874" "False" "High" "IsMasterProtein" "Q02086" "Transcription factor Sp2 OS=Homo sapiens OX=9606 GN=SP2 PE=1 SV=3" "0.000" "False" "10.694" "4" "2" "2" "2" "613" "64.9" "9.92" "8.41" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6668" "ENSG00000167182" "SP2" "A6NK74; hsa:6668; Q02086" "" "" "0" "0" "0.997" "1.095" "1.013" "1.150" "0.999" "0.989" "1.064" "1.038" "1.056" "301.7" "300.9" "330.4" "305.6" "346.9" "301.3" "298.5" "320.9" "313.2" "318.7" "" "" "" "" "" "" "" "" "" "" "242.3" "217.1" "262.4" "204.8" "239.9" "226.1" "209.0" "234.4" "313.2" "259.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889499803111270787" "False" "High" "IsMasterProtein" "O43824" "Putative GTP-binding protein 6 OS=Homo sapiens OX=9606 GN=GTPBP6 PE=1 SV=4" "0.000" "False" "10.672" "6" "3" "3" "3" "516" "56.9" "9.42" "10.53" "3" "" "other cell component" "translation activity;other molecular function" "Pf01926, Pf13167, Pf16360" "8225" "ENSG00000178605; ENSG00000292358" "GTPBP6" "H0Y2S1; hsa:8225; O43824; Q53F77; Q5HYX8" "" "" "0" "0" "0.918" "0.902" "1.118" "1.000" "0.843" "0.949" "1.079" "1.055" "0.922" "121.0" "111.1" "109.1" "135.3" "121.0" "102.0" "114.8" "130.6" "127.7" "111.5" "" "" "" "" "" "" "" "" "" "" "97.2" "80.2" "86.7" "90.7" "83.7" "76.5" "80.4" "95.4" "127.7" "90.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7167041566668473319" "False" "High" "IsMasterProtein" "Q96RK0" "Protein capicua homolog OS=Homo sapiens OX=9606 GN=CIC PE=1 SV=3" "0.000" "False" "10.669" "1" "2" "2" "2" "2517" "257.9" "8.10" "7.25" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf16090" "23152" "ENSG00000079432" "CIC" "A0A7P0T9K5" "" "" "0" "0" "1.098" "1.124" "1.263" "1.094" "1.138" "0.976" "1.192" "1.215" "1.144" "120.9" "132.7" "135.9" "152.8" "132.3" "137.6" "118.0" "144.2" "147.0" "138.4" "" "" "" "" "" "" "" "" "" "" "97.1" "95.8" "108.0" "102.4" "91.5" "103.2" "82.6" "105.3" "147.0" "112.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4037115124737055274" "False" "High" "IsMasterProtein" "P04439" "HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2" "0.000" "False" "10.658" "5" "2" "2" "1" "365" "40.8" "6.00" "7.49" "2" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3105" "ENSG00000206503" "HLA-A" "B1PKZ3; hsa:3105; O02939; O02954; O02955; O02963; O19509; O19546; O19598; O19605; O19606; O19619; O19647; O19673; O19687; O19695; O19756; O19794; O19795; O43906; O43907; O46874; O62921; O62924; O77937; O77938; O77964; O78073; O78171; O98009; O98010; O98011; O98137; P01891; P01892; P04439; P05534; P06338; P10313; P10314; P10315; P10316; P13746; P16188; P16189; P16190; P18462; P30443; P30444; P30445; P30446; P30447; P30448; P30449; P30450; P30451; P30452; P30453; P30454; P30455; P30456; P30457; P30458; P30459; P30512; P30514; P79505; P79562; P79563; Q09160; Q29680; Q29747; Q29835; Q29837; Q29838; Q29899; Q29908; Q29909; Q29910; Q30208; Q31623; Q5S3G1; Q65A82; Q8MHM1; Q8MHN9; Q95352; Q95355; Q95362; Q95377; Q95380; Q95IZ5; Q9BCN0; Q9BD15; Q9BD19; Q9GJE6; Q9GJE7; Q9GJE8; Q9MW42; Q9MY89; Q9MYA3; Q9MYA5; Q9MYC4; Q9MYE6; Q9MYE9; Q9MYG4; Q9MYG5; Q9MYI5; Q9TP25; Q9TPQ3; Q9TPR8; Q9TPX8; Q9TPX9; Q9TPY0; Q9TQ24; Q9TQE8; Q9TQE9; Q9TQF1; Q9TQF5; Q9TQF8; Q9TQF9; Q9TQG0; Q9TQG5; Q9TQG7; Q9TQH5; Q9TQI3; Q9TQK5; Q9TQM6; Q9TQN5; Q9TQP5; Q9TQP6; Q9TQP7; Q9UIN1; Q9UIN2; Q9UIP7; Q9UQU3; Q9UQU6; Q9UQU7" "Nef mediated downregulation of MHC class I complex cell surface expression; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; E3 ubiquitin ligases ubiquitinate target proteins; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; TAR syndrome" "14" "0" "0.928" "0.845" "1.074" "1.095" "0.985" "1.443" "1.062" "1.056" "0.981" "191.5" "177.7" "161.7" "205.7" "209.7" "188.6" "276.2" "203.3" "202.2" "187.9" "" "" "" "" "" "" "" "" "" "" "153.8" "128.2" "128.5" "137.8" "145.1" "141.5" "193.4" "148.5" "202.2" "152.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4106858905325956782" "False" "High" "IsMasterProtein" "P17483" "Homeobox protein Hox-B4 OS=Homo sapiens OX=9606 GN=HOXB4 PE=1 SV=2" "0.000" "False" "10.639" "8" "2" "2" "2" "251" "27.6" "9.77" "5.35" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "3214" "ENSG00000182742" "HOXB4" "hsa:3214; P17483; Q9NTA0" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the nephric duct" "" "2" "0" "1.047" "1.003" "0.982" "0.957" "0.927" "0.992" "0.905" "1.009" "0.991" "401.4" "420.4" "402.7" "394.1" "384.0" "372.0" "398.4" "363.4" "404.9" "398.0" "" "" "" "" "" "" "" "" "" "" "322.4" "303.3" "319.9" "264.0" "265.5" "279.1" "278.9" "265.4" "404.9" "323.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441790046039018783" "False" "High" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "0.000" "False" "10.634" "16" "4" "6" "4" "213" "23.9" "8.76" "14.43" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "Pyroptosis; Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Late endosomal microautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "1.085" "1.034" "1.003" "0.916" "0.945" "1.001" "1.007" "1.012" "1.034" "533.0" "578.2" "551.0" "534.5" "488.0" "503.5" "533.7" "536.8" "539.3" "551.2" "" "" "" "" "" "" "" "" "" "" "428.1" "417.2" "437.6" "358.1" "337.5" "377.8" "373.7" "392.0" "539.3" "448.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848560432404461068" "False" "High" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "0.000" "False" "10.633" "12" "3" "3" "3" "308" "33.8" "8.12" "6.28" "3" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "0.920" "0.781" "0.943" "1.180" "0.910" "0.997" "0.868" "0.826" "0.865" "65.1" "59.9" "50.8" "61.3" "76.8" "59.2" "64.9" "56.5" "53.7" "56.3" "" "" "" "" "" "" "" "" "" "" "52.3" "43.2" "40.4" "41.1" "53.1" "44.4" "45.4" "41.2" "53.7" "45.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8586045646890195007" "False" "High" "IsMasterProtein" "P20020" "Plasma membrane calcium-transporting ATPase 1 OS=Homo sapiens OX=9606 GN=ATP2B1 PE=1 SV=4" "0.000" "False" "10.621" "2" "1" "2" "1" "1220" "134.6" "5.91" "8.00" "1" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf00702, Pf12424, Pf13246" "490" "ENSG00000070961" "ATP2B1" "hsa:490; P20020; Q12992; Q12993; Q13819; Q13820; Q13821; Q16504; Q93082" "Sensory processing of sound by inner hair cells of the cochlea; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels" "Vitamin D receptor pathway; Splicing factor NOVA regulated synaptic proteins; Vitamin D-sensitive calcium signaling in depression; Calcium regulation in cardiac cells" "8" "0" "0.826" "1.025" "1.077" "1.358" "1.008" "1.282" "1.506" "1.230" "1.387" "212.0" "175.1" "217.3" "228.4" "288.0" "213.8" "271.8" "319.3" "260.8" "294.0" "" "" "" "" "" "" "" "" "" "" "170.3" "126.3" "172.6" "153.0" "199.2" "160.4" "190.3" "233.2" "260.8" "239.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "282539810863181563" "False" "High" "IsMasterProtein" "Q9UL40" "Zinc finger protein 346 OS=Homo sapiens OX=9606 GN=ZNF346 PE=1 SV=1" "0.000" "False" "10.618" "12" "3" "4" "3" "294" "32.9" "9.09" "11.43" "3" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "23567" "ENSG00000113761" "ZNF346" "B7Z367; hsa:23567; Q68CV9; Q6ZMW1; Q9UL40" "" "5q35 copy number variation" "1" "0" "0.888" "0.866" "0.967" "0.959" "0.972" "1.052" "0.852" "0.944" "0.934" "131.6" "116.8" "113.9" "127.3" "126.2" "127.9" "138.4" "112.1" "124.2" "122.9" "" "" "" "" "" "" "" "" "" "" "105.7" "84.3" "90.5" "85.3" "87.3" "95.9" "96.9" "81.9" "124.2" "100.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4893836570063627970" "False" "High" "IsMasterProtein" "O75494" "Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1" "0.000" "False" "10.614" "15" "4" "4" "4" "262" "31.3" "11.27" "8.62" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10772" "ENSG00000188529" "SRSF10" "A6NFM6; A6NI42; A6NIU7; B4DJP9; hsa:10772; O60572; O75494; Q5JRH9; Q5JRI0; Q5JRI2; Q5JRI3; Q5JRI4; Q96G09; Q96P17" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7631092510034682888" "False" "High" "IsMasterProtein" "P31025" "Lipocalin-1 OS=Homo sapiens OX=9606 GN=LCN1 PE=1 SV=1" "0.000" "False" "10.594" "6" "1" "2" "1" "176" "19.2" "5.58" "8.25" "1" "protein metabolism;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00061" "3933" "ENSG00000160349" "LCN1" "hsa:3933; P31025; Q5T8A1" "Transport of fatty acids" "" "1" "0" "18.150" "0.680" "0.630" "0.917" "0.932" "0.862" "0.939" "0.938" "1.007" "88.8" "1611.8" "60.4" "56.0" "81.4" "82.8" "76.5" "83.4" "83.3" "89.4" "" "" "" "" "" "" "" "" "" "" "71.3" "1163.0" "48.0" "37.5" "56.3" "62.1" "53.6" "60.9" "83.3" "72.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6522412944191385699" "False" "High" "IsMasterProtein" "Q9HCM7" "Fibrosin-1-like protein OS=Homo sapiens OX=9606 GN=FBRSL1 PE=1 SV=4" "0.000" "False" "10.570" "2" "2" "2" "2" "1045" "110.8" "9.67" "6.27" "2" "" "" "" "Pf15336" "57666" "ENSG00000112787" "FBRSL1" "hsa:57666; Q86XQ1; Q9HCM7" "" "" "0" "0" "1.006" "1.055" "1.009" "0.914" "1.067" "1.011" "1.006" "1.131" "1.171" "115.2" "115.9" "121.6" "116.3" "105.3" "122.9" "116.5" "115.9" "130.3" "135.0" "" "" "" "" "" "" "" "" "" "" "92.6" "83.6" "96.6" "77.9" "72.8" "92.2" "81.5" "84.6" "130.3" "109.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8147219015132361751" "False" "High" "IsMasterProtein" "Q96A19" "Coiled-coil domain-containing protein 102A OS=Homo sapiens OX=9606 GN=CCDC102A PE=1 SV=2" "0.000" "False" "10.566" "5" "2" "3" "2" "550" "62.6" "5.58" "10.65" "2" "" "cytoskeleton" "" "Pf01576" "92922" "ENSG00000135736" "CCDC102A" "hsa:92922; Q96A19; Q9BT74" "" "" "0" "0" "0.856" "1.041" "1.124" "0.885" "0.980" "0.995" "0.909" "0.903" "1.063" "84.6" "72.4" "88.1" "95.1" "74.9" "82.9" "84.1" "76.9" "76.4" "89.9" "" "" "" "" "" "" "" "" "" "" "67.9" "52.3" "70.0" "63.7" "51.8" "62.2" "58.9" "56.1" "76.4" "73.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3563159699507819169" "False" "High" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "0.000" "False" "10.561" "10" "4" "4" "4" "429" "48.7" "5.60" "8.68" "4" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Neutrophil degranulation; Glycosphingolipid catabolism" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "4" "0" "1.187" "0.902" "1.164" "1.123" "1.176" "0.862" "0.847" "1.157" "0.892" "33.1" "39.4" "29.9" "38.6" "37.2" "39.0" "28.6" "28.1" "38.3" "29.6" "" "" "" "" "" "" "" "" "" "" "26.6" "28.4" "23.7" "25.9" "25.7" "29.3" "20.0" "20.5" "38.3" "24.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179808201318642480" "False" "High" "IsMasterProtein" "Cont_Q3SZR3" "Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1" "0.000" "True" "10.548" "12" "3" "3" "3" "202" "23.2" "5.87" "11.30" "3" "stress response;other biological processes" "non-structural extracellular" "" "Pf00061" "497200" "" "ORM1" "bta:497200; Q3SZR3" "" "" "0" "0" "0.934" "0.933" "1.047" "0.957" "1.128" "1.723" "1.104" "1.107" "1.113" "543.9" "508.1" "507.4" "569.6" "520.4" "613.3" "937.0" "600.2" "602.3" "605.6" "" "" "" "" "" "" "" "" "" "" "436.9" "366.6" "403.1" "381.6" "359.9" "460.2" "656.0" "438.4" "602.3" "492.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2074616655413557886" "False" "High" "IsMasterProtein" "Q9HB20" "Pleckstrin homology domain-containing family A member 3 OS=Homo sapiens OX=9606 GN=PLEKHA3 PE=1 SV=2" "0.000" "False" "10.545" "7" "2" "3" "2" "300" "33.8" "6.65" "8.12" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00169" "65977" "ENSG00000116095" "PLEKHA3" "hsa:65977; Q4ZG69; Q86TQ1; Q9HB20; Q9NXT3" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "1.057" "1.026" "1.158" "1.126" "1.014" "1.068" "0.989" "1.115" "1.100" "237.7" "251.3" "244.0" "275.3" "267.6" "241.1" "254.0" "235.2" "265.2" "261.6" "" "" "" "" "" "" "" "" "" "" "190.9" "181.3" "193.8" "184.4" "185.1" "180.9" "177.8" "171.8" "265.2" "212.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-163153293796965969" "False" "High" "IsMasterProtein" "Q9NWB6" "Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1" "0.000" "False" "10.544" "11" "4" "7" "3" "273" "33.2" "10.35" "16.10" "4" "" "cytosol;mitochondrion;nucleus" "" "Pf15346" "55082" "ENSG00000134884" "ARGLU1" "B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6" "" "" "0" "0" "1.012" "1.027" "1.115" "1.059" "1.213" "1.162" "1.149" "1.051" "1.096" "130.4" "132.0" "134.0" "145.5" "138.1" "158.3" "151.6" "149.8" "137.1" "143.0" "" "" "" "" "" "" "" "" "" "" "104.8" "95.3" "106.4" "97.5" "95.5" "118.7" "106.1" "109.4" "137.1" "116.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2511129465997250368" "False" "High" "IsMasterProtein" "Q9NX07" "tRNA selenocysteine 1-associated protein 1 OS=Homo sapiens OX=9606 GN=TRNAU1AP PE=1 SV=1" "0.000" "False" "10.539" "9" "3" "3" "3" "287" "32.5" "4.74" "10.40" "3" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf17654" "54952" "ENSG00000180098" "TRNAU1AP" "hsa:54952; Q86SU7; Q9NX07" "" "Selenium metabolism and selenoproteins" "1" "0" "1.020" "0.999" "0.917" "0.966" "0.995" "0.916" "1.022" "1.097" "1.045" "719.8" "734.3" "719.4" "660.0" "695.0" "715.9" "659.1" "735.7" "789.4" "752.0" "" "" "" "" "" "" "" "" "" "" "578.2" "529.9" "571.5" "442.2" "480.7" "537.1" "461.4" "537.3" "789.4" "611.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3349657221176052038" "False" "High" "IsMasterProtein" "O00750" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta OS=Homo sapiens OX=9606 GN=PIK3C2B PE=1 SV=2" "0.000" "False" "10.534" "2" "3" "3" "3" "1634" "184.7" "7.30" "6.23" "3" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5287" "ENSG00000133056" "PIK3C2B" "hsa:5287; O00750; O95666; Q5SW99" "Synthesis of PIPs at the plasma membrane" "Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "8" "0" "1.010" "0.908" "1.052" "0.863" "0.823" "0.871" "0.761" "0.857" "0.812" "323.2" "326.6" "293.4" "340.0" "279.0" "266.0" "281.6" "246.1" "277.1" "262.5" "" "" "" "" "" "" "" "" "" "" "259.6" "235.7" "233.1" "227.8" "193.0" "199.6" "197.2" "179.7" "277.1" "213.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776165374606149247" "False" "High" "IsMasterProtein" "Q99547" "M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2" "0.000" "False" "10.523" "16" "3" "4" "3" "160" "19.0" "5.20" "12.69" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf10175" "10200" "ENSG00000135698" "MPHOSPH6" "B2RAF0; hsa:10200; Q99547" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.087" "1.028" "1.005" "1.033" "1.130" "1.250" "1.209" "1.101" "1.022" "241.7" "262.7" "248.5" "243.0" "249.7" "273.2" "302.0" "292.2" "266.0" "247.0" "" "" "" "" "" "" "" "" "" "" "194.1" "189.6" "197.4" "162.8" "172.7" "205.0" "211.5" "213.4" "266.0" "200.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6202573485252222351" "False" "High" "IsMasterProtein" "Q9NZD2" "Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3" "0.000" "False" "10.518" "11" "2" "2" "2" "209" "23.8" "7.39" "7.11" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol" "transporter activity;other molecular function" "Pf08718" "51228" "ENSG00000139433" "GLTP" "hsa:51228; Q53Z13; Q96J68; Q9NZD2" "Glycosphingolipid transport" "" "1" "0" "1.135" "0.959" "1.077" "0.846" "1.032" "0.842" "0.947" "1.063" "0.832" "172.4" "195.6" "165.3" "185.6" "145.9" "177.9" "145.1" "163.3" "183.3" "143.5" "" "" "" "" "" "" "" "" "" "" "138.5" "141.2" "131.3" "124.3" "100.9" "133.5" "101.6" "119.2" "183.3" "116.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-784260624989064323" "False" "High" "IsMasterProtein" "Q9H0N0" "Ras-related protein Rab-6C OS=Homo sapiens OX=9606 GN=RAB6C PE=1 SV=2" "0.000" "False" "10.513" "9" "1" "1" "1" "254" "28.3" "7.71" "5.67" "1" "cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "84084" "ENSG00000222014; ENSG00000292140" "RAB6C" "hsa:84084; Q53RU3; Q6FIF7; Q9H0N0; Q9P128" "" "" "0" "0" "1.100" "1.257" "1.089" "1.126" "1.373" "1.010" "0.969" "0.938" "1.152" "55.0" "60.5" "69.2" "59.9" "62.0" "75.6" "55.6" "53.3" "51.6" "63.4" "" "" "" "" "" "" "" "" "" "" "44.2" "43.7" "54.9" "40.1" "42.9" "56.7" "38.9" "39.0" "51.6" "51.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-379596745727063060" "False" "High" "IsMasterProtein" "Q96CW6" "Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Homo sapiens OX=9606 GN=SLC7A6OS PE=1 SV=2" "0.000" "False" "10.501" "14" "5" "5" "5" "309" "35.0" "4.60" "12.67" "5" "transport;other biological processes" "nucleus;other cell component" "" "Pf08574" "84138" "ENSG00000103061" "SLC7A6OS" "hsa:84138; Q8TCZ3; Q96CW6; Q9H8R8" "" "" "0" "0" "1.067" "1.087" "1.013" "0.988" "1.030" "1.061" "1.067" "1.128" "1.075" "475.0" "506.9" "516.4" "481.1" "469.4" "489.2" "504.0" "506.7" "535.6" "510.7" "" "" "" "" "" "" "" "" "" "" "381.6" "365.8" "410.2" "322.3" "324.6" "367.0" "352.9" "370.1" "535.6" "415.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1820154667624248039" "False" "High" "IsMasterProtein" "P54098" "DNA polymerase subunit gamma-1 OS=Homo sapiens OX=9606 GN=POLG PE=1 SV=1" "0.000" "False" "10.501" "2" "2" "2" "2" "1239" "139.5" "6.90" "8.95" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf18136" "5428" "ENSG00000140521" "POLG" "hsa:5428; P54098; Q8NFM2; Q92515" "" "Male infertility; Primary ovarian insufficiency" "2" "0" "1.095" "1.049" "1.113" "1.207" "1.079" "1.221" "1.151" "1.023" "1.155" "72.0" "78.8" "75.5" "80.1" "86.9" "77.7" "87.9" "82.9" "73.7" "83.1" "" "" "" "" "" "" "" "" "" "" "57.8" "56.8" "60.0" "53.7" "60.1" "58.3" "61.5" "60.5" "73.7" "67.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5693736025540312441" "False" "High" "IsMasterProtein" "P0CG12" "Decreased expression in renal and prostate cancer protein OS=Homo sapiens OX=9606 GN=DERPC PE=1 SV=1" "0.000" "False" "10.493" "4" "2" "2" "2" "524" "51.4" "12.41" "7.52" "2" "" "nucleus" "" "" "" "ENSG00000286140" "DERPC" "A8MYX8; P0CG12; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "" "" "0" "0" "0.976" "0.896" "1.045" "1.175" "0.935" "1.003" "1.228" "1.015" "0.983" "243.2" "237.4" "217.9" "254.0" "285.8" "227.3" "244.0" "298.6" "246.9" "239.0" "" "" "" "" "" "" "" "" "" "" "195.3" "171.3" "173.1" "170.2" "197.6" "170.5" "170.8" "218.1" "246.9" "194.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8019113709048034538" "False" "High" "IsMasterProtein" "Q9NPE3" "H/ACA ribonucleoprotein complex subunit 3 OS=Homo sapiens OX=9606 GN=NOP10 PE=1 SV=1" "0.000" "False" "10.490" "45" "2" "3" "2" "64" "7.7" "9.99" "8.63" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04135" "55505" "ENSG00000182117; ENSG00000291996" "NOP10" "hsa:55505; Q9NPE3" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "1.041" "1.193" "1.169" "1.273" "1.119" "1.190" "1.048" "1.126" "1.246" "127.1" "132.3" "151.7" "148.6" "161.8" "142.2" "151.3" "133.2" "143.1" "158.4" "" "" "" "" "" "" "" "" "" "" "102.1" "95.5" "120.5" "99.6" "111.9" "106.7" "105.9" "97.3" "143.1" "128.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2069331310574252297" "False" "High" "IsMasterProtein" "O43708" "Maleylacetoacetate isomerase OS=Homo sapiens OX=9606 GN=GSTZ1 PE=1 SV=3" "0.000" "False" "10.489" "17" "3" "6" "3" "216" "24.2" "8.54" "18.19" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf13409, Pf14497" "2954" "ENSG00000100577" "GSTZ1" "A6NED0; A6NNB8; A8MWD7; B2RCK3; hsa:2954; O15308; O43708; O75430; Q6IB17; Q7Z610; Q9BV63" "Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism" "Metapathway biotransformation Phase I and II" "4" "0" "1.014" "0.904" "1.044" "0.989" "0.907" "1.069" "1.003" "0.870" "0.872" "128.3" "130.1" "116.0" "134.0" "126.9" "116.3" "137.2" "128.7" "111.7" "111.9" "" "" "" "" "" "" "" "" "" "" "103.1" "93.9" "92.1" "89.8" "87.8" "87.3" "96.1" "94.0" "111.7" "91.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2792434032950857374" "False" "High" "IsMasterProtein" "Q96HR3" "Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1" "0.000" "False" "10.485" "12" "2" "2" "2" "178" "20.3" "8.27" "6.51" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11315" "90390" "ENSG00000164758" "MED30" "C6GKU9; hsa:90390; Q96HR3" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "4" "0" "1.059" "0.884" "1.126" "1.151" "0.997" "0.916" "1.017" "0.938" "1.159" "100.9" "106.8" "89.2" "113.6" "116.1" "100.6" "92.4" "102.6" "94.6" "116.9" "" "" "" "" "" "" "" "" "" "" "81.0" "77.0" "70.8" "76.1" "80.3" "75.4" "64.7" "74.9" "94.6" "95.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-789511479774361380" "False" "High" "IsMasterProtein" "Q14202" "Zinc finger MYM-type protein 3 OS=Homo sapiens OX=9606 GN=ZMYM3 PE=1 SV=2" "0.000" "False" "10.478" "2" "2" "3" "2" "1370" "152.3" "6.35" "8.95" "2" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9203" "ENSG00000147130" "ZMYM3" "D3DVV3; hsa:9203; O15089; Q14202; Q96E26" "" "Orexin receptor pathway" "1" "0" "1.016" "1.020" "1.033" "1.057" "1.101" "0.964" "1.091" "1.031" "0.956" "98.8" "100.3" "100.7" "102.0" "104.3" "108.7" "95.2" "107.8" "101.8" "94.4" "" "" "" "" "" "" "" "" "" "" "79.3" "72.4" "80.0" "68.3" "72.2" "81.5" "66.7" "78.7" "101.8" "76.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3451981213719268513" "False" "High" "IsMasterProtein" "Q9Y5Y6" "Suppressor of tumorigenicity 14 protein OS=Homo sapiens OX=9606 GN=ST14 PE=1 SV=2" "0.000" "False" "10.468" "4" "3" "4" "3" "855" "94.7" "6.55" "5.03" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00057, Pf00089, Pf00431, Pf01390" "6768" "ENSG00000149418" "ST14" "hsa:6768; Q9BS01; Q9H3S0; Q9HB36; Q9HCA3; Q9Y5Y6" "Formation of the cornified envelope" "" "1" "0" "0.972" "1.065" "1.001" "1.101" "1.127" "1.203" "1.001" "1.095" "1.041" "124.2" "120.7" "132.3" "124.3" "136.7" "139.9" "149.4" "124.3" "136.0" "129.2" "" "" "" "" "" "" "" "" "" "" "99.7" "87.1" "105.1" "83.3" "94.5" "105.0" "104.6" "90.8" "136.0" "105.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469861955524626528" "False" "High" "IsMasterProtein" "Q9BTX7" "Alpha-tocopherol transfer protein-like OS=Homo sapiens OX=9606 GN=TTPAL PE=1 SV=2" "0.000" "False" "10.461" "8" "2" "3" "2" "342" "38.5" "6.44" "6.01" "2" "" "" "other molecular function" "Pf00650, Pf03765" "79183" "ENSG00000124120" "TTPAL" "E1P5X3; hsa:79183; Q5QPC1; Q9BTX7; Q9H1G2; Q9NQG8" "" "" "0" "0" "1.140" "1.022" "1.144" "1.242" "1.057" "1.024" "1.270" "0.992" "1.076" "16.5" "18.8" "16.9" "18.9" "20.5" "17.5" "16.9" "21.0" "16.4" "17.8" "" "" "" "" "" "" "" "" "" "" "13.3" "13.6" "13.4" "12.7" "14.2" "13.1" "11.9" "15.3" "16.4" "14.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6200383293614890998" "False" "High" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "0.000" "False" "10.442" "29" "4" "8" "4" "103" "11.6" "5.27" "25.16" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "mRNA processing" "3" "0" "1.123" "1.104" "1.024" "0.910" "1.040" "0.969" "1.004" "1.005" "0.951" "1286.9" "1444.9" "1420.4" "1317.7" "1170.6" "1338.3" "1247.0" "1292.4" "1293.5" "1223.3" "" "" "" "" "" "" "" "" "" "" "1033.6" "1042.6" "1128.3" "882.8" "809.6" "1004.1" "873.1" "943.9" "1293.5" "994.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8069107240958525203" "False" "High" "IsMasterProtein" "Q92993" "Histone acetyltransferase KAT5 OS=Homo sapiens OX=9606 GN=KAT5 PE=1 SV=2" "0.000" "False" "10.430" "4" "2" "3" "2" "513" "58.5" "8.48" "11.02" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "10524" "ENSG00000172977" "KAT5" "B4E3C7; C9JL99; hsa:10524; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q92993; Q9BWK7" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Estrogen-dependent gene expression; Regulation of TP53 Activity through Phosphorylation; HATs acetylate histones; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Cardiogenesis; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks" "Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; HDAC6 interactions in the central nervous system" "27" "0" "0.998" "1.079" "1.052" "0.944" "0.972" "0.932" "0.953" "0.919" "0.992" "147.0" "146.6" "158.6" "154.7" "138.7" "142.9" "137.0" "140.0" "135.1" "145.8" "" "" "" "" "" "" "" "" "" "" "118.1" "105.8" "126.0" "103.6" "96.0" "107.2" "96.0" "102.3" "135.1" "118.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710648290314938534" "False" "High" "IsMasterProtein" "P01906" "HLA class II histocompatibility antigen, DQ alpha 2 chain OS=Homo sapiens OX=9606 GN=HLA-DQA2 PE=1 SV=2" "0.000" "False" "10.418" "7" "2" "3" "1" "255" "28.0" "4.88" "12.42" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00993, Pf07654" "3118" "ENSG00000206301; ENSG00000223793; ENSG00000225103; ENSG00000231526; ENSG00000231823; ENSG00000233192; ENSG00000237541; ENSG00000257473" "HLA-DQA2" "A2BF37; B0V0E7; hsa:3118; O19789; P01906; Q5SQ94; Q5SR04" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host" "9" "0" "0.951" "1.042" "0.980" "1.035" "1.035" "1.120" "0.941" "0.997" "0.958" "303.5" "288.6" "316.3" "297.3" "314.1" "314.1" "339.8" "285.4" "302.6" "290.6" "" "" "" "" "" "" "" "" "" "" "243.7" "208.3" "251.2" "199.2" "217.2" "235.7" "237.9" "208.4" "302.6" "236.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4479122024934742870" "False" "High" "IsMasterProtein" "Q92934" "Bcl2-associated agonist of cell death OS=Homo sapiens OX=9606 GN=BAD PE=1 SV=3" "0.000" "False" "10.417" "23" "2" "2" "2" "168" "18.4" "7.15" "5.48" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf10514" "572" "ENSG00000002330" "BAD" "hsa:572; O14803; Q6FH21; Q92934" "NRAGE signals death through JNK; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of BAD and translocation to mitochondria" "Leptin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; NO/cGMP/PKG mediated neuroprotection; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent)" "42" "0" "1.040" "0.874" "0.862" "0.904" "0.802" "0.967" "0.727" "1.123" "1.014" "28.4" "29.5" "24.8" "24.5" "25.7" "22.8" "27.5" "20.6" "31.9" "28.8" "" "" "" "" "" "" "" "" "" "" "22.8" "21.3" "19.7" "16.4" "17.7" "17.1" "19.2" "15.1" "31.9" "23.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5985118232380264359" "False" "High" "IsMasterProtein" "Q15363" "Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1" "0.000" "False" "10.417" "15" "3" "3" "3" "201" "22.7" "5.17" "8.55" "3" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "Pf01105" "10959" "ENSG00000086598" "TMED2" "hsa:10959; Q15363" "COPII-mediated vesicle transport; Cargo concentration in the ER; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Pre-NOTCH Processing in Golgi" "5q35 copy number variation" "6" "0" "0.829" "0.885" "0.856" "0.800" "0.949" "1.004" "0.776" "0.892" "0.858" "101.6" "84.2" "89.9" "86.9" "81.3" "96.4" "101.9" "78.8" "90.6" "87.1" "" "" "" "" "" "" "" "" "" "" "81.6" "60.7" "71.4" "58.2" "56.2" "72.3" "71.4" "57.6" "90.6" "70.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516634271704807455" "False" "High" "IsMasterProtein" "Q9BUK0" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Homo sapiens OX=9606 GN=CHCHD7 PE=1 SV=1" "0.000" "False" "10.405" "21" "1" "1" "1" "85" "10.1" "8.82" "6.04" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf02297" "79145" "ENSG00000170791" "CHCHD7" "A8K223; E9PBH3; hsa:79145; J3KNE9; Q7Z588; Q9BUK0" "Mitochondrial protein import" "" "1" "0" "1.036" "1.110" "1.095" "1.139" "0.916" "1.110" "1.036" "1.142" "0.963" "105.8" "109.6" "117.4" "115.8" "120.6" "97.0" "117.5" "109.6" "120.9" "101.9" "" "" "" "" "" "" "" "" "" "" "85.0" "79.1" "93.3" "77.6" "83.4" "72.8" "82.3" "80.0" "120.9" "82.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3899808669823360054" "False" "High" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "0.000" "False" "10.395" "4" "3" "3" "3" "911" "99.9" "7.55" "7.71" "3" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "RAC1 GTPase cycle; RAC3 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "Envelope proteins and their potential roles in EDMD physiopathology" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6309414575858280989" "False" "High" "IsMasterProtein" "Q9GZQ3" "COMM domain-containing protein 5 OS=Homo sapiens OX=9606 GN=COMMD5 PE=1 SV=1" "0.000" "False" "10.392" "16" "3" "3" "3" "224" "24.7" "7.02" "10.21" "3" "" "cytosol;nucleus" "" "Pf07258, Pf21672" "28991" "ENSG00000170619" "COMMD5" "D3DWN7; hsa:28991; Q9GZQ3; Q9NVN6; Q9UHX5" "Neddylation" "" "1" "0" "0.971" "0.637" "0.909" "0.936" "0.649" "1.052" "0.857" "0.843" "0.870" "56.5" "54.9" "36.0" "51.4" "52.9" "36.7" "59.5" "48.4" "47.6" "49.2" "" "" "" "" "" "" "" "" "" "" "45.4" "39.6" "28.6" "34.4" "36.6" "27.5" "41.6" "35.4" "47.6" "40.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613658654748761200" "False" "High" "IsMasterProtein" "P51617" "Interleukin-1 receptor-associated kinase 1 OS=Homo sapiens OX=9606 GN=IRAK1 PE=1 SV=2" "0.000" "False" "10.386" "3" "2" "3" "2" "712" "76.5" "6.62" "8.89" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00531" "3654" "ENSG00000184216" "IRAK1" "D3DWW3; D3DWW4; hsa:3654; P51617; Q7Z5V4; Q96C06; Q96RL2" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PIP3 activates AKT signaling; Transcriptional Regulation by MECP2; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; IL1 and megakaryocytes in obesity; Melatonin metabolism and effects; Interleukin-1 induced activation of NF-kB; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Toll-like receptor signaling pathway" "37" "0" "1.008" "1.077" "1.167" "1.064" "1.085" "1.016" "1.140" "1.120" "1.037" "50.7" "51.1" "54.6" "59.1" "53.9" "55.0" "51.5" "57.8" "56.8" "52.5" "" "" "" "" "" "" "" "" "" "" "40.7" "36.9" "43.4" "39.6" "37.3" "41.2" "36.0" "42.2" "56.8" "42.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2743146227967072639" "False" "High" "IsMasterProtein" "Q86WP2" "Vasculin OS=Homo sapiens OX=9606 GN=GPBP1 PE=1 SV=1" "0.000" "False" "10.381" "5" "2" "3" "2" "473" "53.3" "7.05" "8.02" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15337" "65056" "ENSG00000062194" "GPBP1" "A6NKW3; hsa:65056; Q6NSH6; Q86WP2; Q9H0D4; Q9H785; Q9NSN4" "" "" "0" "0" "1.047" "1.635" "1.374" "1.388" "1.265" "1.400" "1.468" "1.366" "1.464" "24.2" "25.3" "39.5" "33.2" "33.6" "30.6" "33.8" "35.5" "33.0" "35.4" "" "" "" "" "" "" "" "" "" "" "19.4" "18.3" "31.4" "22.3" "23.2" "23.0" "23.7" "25.9" "33.0" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5445595242509398747" "False" "High" "IsMasterProtein" "Q9UQL6" "Histone deacetylase 5 OS=Homo sapiens OX=9606 GN=HDAC5 PE=1 SV=2" "0.000" "False" "10.370" "3" "4" "4" "4" "1122" "121.9" "6.24" "10.45" "4" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "10014" "ENSG00000108840" "HDAC5" "C9JFV9; hsa:10014; O60340; O60528; Q96DY4; Q9UQL6" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of PTEN gene transcription" "MicroRNAs in cardiomyocyte hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome" "14" "0" "1.129" "1.227" "1.366" "0.953" "0.769" "1.222" "0.962" "1.222" "0.911" "25.5" "28.8" "31.3" "34.9" "24.3" "19.6" "31.2" "24.6" "31.2" "23.3" "" "" "" "" "" "" "" "" "" "" "20.5" "20.8" "24.9" "23.4" "16.8" "14.7" "21.8" "17.9" "31.2" "18.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1388353290409054284" "False" "High" "IsMasterProtein" "Q9NNW7" "Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3" "0.000" "False" "10.340" "7" "3" "6" "3" "524" "56.5" "7.50" "19.84" "3" "stress response;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf02852, Pf07992" "10587" "ENSG00000184470" "TXNRD2" "hsa:10587; O95840; Q96IJ2; Q9H2Z5; Q9NNW7; Q9NZV3; Q9NZV4; Q9P2Y0; Q9P2Y1; Q9UQU8" "Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Oxidative stress response; 22q11.2 copy number variation syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5731333323507382333" "False" "High" "IsMasterProtein" "Q8NB78" "Lysine-specific histone demethylase 2 OS=Homo sapiens OX=9606 GN=KDM1B PE=1 SV=3" "0.000" "False" "10.339" "4" "3" "3" "3" "822" "92.0" "7.87" "8.54" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01593, Pf04433, Pf07496" "221656" "ENSG00000165097" "KDM1B" "A2A2C5; A2A2C6; hsa:221656; Q5TGV3; Q6AI15; Q6ZUU4; Q8N258; Q8NB78; Q96EL7" "HDMs demethylate histones; UCH proteinases; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "Vitamin D-sensitive calcium signaling in depression" "4" "0" "1.047" "0.899" "1.165" "1.114" "1.413" "1.203" "1.235" "1.130" "1.073" "47.5" "49.7" "42.7" "55.3" "52.9" "67.1" "57.1" "58.6" "53.6" "50.9" "" "" "" "" "" "" "" "" "" "" "38.1" "35.9" "33.9" "37.0" "36.6" "50.3" "40.0" "42.8" "53.6" "41.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3425744660855709231" "False" "High" "IsMasterProtein" "O60568" "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1" "0.000" "False" "10.334" "6" "4" "4" "4" "738" "84.7" "6.05" "5.30" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf03171" "8985" "ENSG00000106397" "PLOD3" "B2R6W6; hsa:8985; O60568; Q540C3" "Collagen biosynthesis and modifying enzymes" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "3" "0" "1.085" "0.916" "0.807" "0.904" "0.863" "1.033" "0.872" "1.021" "0.934" "94.3" "102.4" "86.4" "76.1" "85.3" "81.4" "97.4" "82.3" "96.3" "88.1" "" "" "" "" "" "" "" "" "" "" "75.8" "73.9" "68.6" "51.0" "59.0" "61.1" "68.2" "60.1" "96.3" "71.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7587381805021517015" "False" "High" "IsMasterProtein" "Q8IUC6" "TIR domain-containing adapter molecule 1 OS=Homo sapiens OX=9606 GN=TICAM1 PE=1 SV=1" "0.000" "False" "10.321" "5" "4" "5" "4" "712" "76.4" "5.41" "14.12" "4" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf12721, Pf17798" "148022" "ENSG00000127666" "TICAM1" "B3Y691; hsa:148022; O75532; Q86XP8; Q8IUC6; Q96GA0" "Caspase activation via Death Receptors in the presence of ligand; MyD88-independent TLR4 cascade ; TRIF-mediated programmed cell death; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TICAM1 deficiency - HSE; TRAF3 deficiency - HSE; TLR3-mediated TICAM1-dependent programmed cell death; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex" "Nanoparticle triggered regulated necrosis; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; Toll-like receptor signaling pathway" "23" "0" "1.045" "0.997" "1.204" "1.200" "0.971" "1.208" "1.157" "1.160" "1.073" "331.0" "346.1" "330.2" "398.6" "397.4" "321.5" "400.0" "382.9" "384.1" "355.3" "" "" "" "" "" "" "" "" "" "" "265.9" "249.7" "262.3" "267.0" "274.8" "241.2" "280.1" "279.6" "384.1" "289.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8104731299280243918" "False" "High" "IsMasterProtein" "Q4G148" "Glucoside xylosyltransferase 1 OS=Homo sapiens OX=9606 GN=GXYLT1 PE=1 SV=2" "0.000" "False" "10.315" "8" "3" "4" "3" "440" "50.5" "8.65" "12.69" "3" "protein metabolism;other metabolic processes" "other membranes" "other molecular function" "Pf01501" "283464" "ENSG00000151233" "GXYLT1" "B3KWJ2; hsa:283464; Q4G148; Q8IXV1; Q96BH4" "" "" "0" "0" "1.031" "1.028" "0.998" "1.133" "1.092" "1.117" "1.147" "1.152" "1.096" "533.4" "550.0" "548.2" "532.2" "604.2" "582.7" "595.8" "611.7" "614.3" "584.5" "" "" "" "" "" "" "" "" "" "" "428.4" "396.9" "435.5" "356.6" "417.9" "437.2" "417.2" "446.8" "614.3" "475.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2026118880241708351" "False" "High" "IsMasterProtein" "A5PLN9" "Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2" "0.000" "False" "10.313" "8" "4" "4" "4" "417" "46.5" "5.60" "11.40" "4" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06159" "80006" "ENSG00000113597" "TRAPPC13" "A5PLN9; hsa:80006; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.072" "1.086" "1.148" "1.053" "1.071" "1.092" "1.093" "1.162" "1.088" "400.1" "428.8" "434.4" "459.4" "421.3" "428.5" "437.0" "437.4" "464.9" "435.2" "" "" "" "" "" "" "" "" "" "" "321.3" "309.4" "345.1" "307.8" "291.4" "321.5" "306.0" "319.5" "464.9" "354.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2196461866191852716" "False" "High" "IsMasterProtein" "Q9Y5J1" "U3 small nucleolar RNA-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=UTP18 PE=1 SV=3" "0.000" "False" "10.299" "3" "1" "1" "1" "556" "62.0" "8.76" "6.98" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "51096" "ENSG00000011260" "UTP18" "hsa:51096; Q9H4N6; Q9Y5J1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.054" "1.206" "1.024" "1.072" "1.094" "0.984" "1.142" "1.128" "1.137" "78.7" "83.0" "94.9" "80.6" "84.3" "86.1" "77.5" "89.9" "88.8" "89.5" "" "" "" "" "" "" "" "" "" "" "63.2" "59.9" "75.4" "54.0" "58.3" "64.6" "54.3" "65.7" "88.8" "72.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828666302567516124" "False" "High" "IsMasterProtein" "Q6P2H3" "Centrosomal protein of 85 kDa OS=Homo sapiens OX=9606 GN=CEP85 PE=1 SV=1" "0.000" "False" "10.292" "6" "4" "4" "4" "762" "85.6" "6.00" "6.84" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "" "64793" "ENSG00000130695" "CEP85" "B4DRL1; D3DPK4; F8W7K4; hsa:64793; Q5VY68; Q5VY70; Q6P2H3; Q9H6Q1; Q9H828; Q9UF52" "" "" "0" "0" "0.947" "1.200" "1.154" "1.101" "1.085" "1.018" "0.833" "0.975" "1.264" "23.9" "22.7" "28.7" "27.6" "26.4" "26.0" "24.4" "20.0" "23.3" "30.3" "" "" "" "" "" "" "" "" "" "" "19.2" "16.4" "22.8" "18.5" "18.2" "19.5" "17.1" "14.6" "23.3" "24.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2733253045392511170" "False" "High" "IsMasterProtein" "P23297" "Protein S100-A1 OS=Homo sapiens OX=9606 GN=S100A1 PE=1 SV=2" "0.000" "False" "10.283" "23" "2" "2" "2" "94" "10.5" "4.50" "7.67" "2" "signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6271" "ENSG00000160678" "S100A1" "B2R5D9; hsa:6271; P23297; Q5T7Y3" "ER-Phagosome pathway; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand" "" "5" "0" "1.315" "1.167" "1.176" "1.135" "1.164" "1.157" "1.118" "1.183" "1.238" "138.6" "182.3" "161.8" "163.0" "157.3" "161.3" "160.4" "155.1" "164.0" "171.7" "" "" "" "" "" "" "" "" "" "" "111.4" "131.5" "128.5" "109.2" "108.8" "121.0" "112.3" "113.2" "164.0" "139.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547321454778217727" "False" "High" "IsMasterProtein" "Q6PID6" "Tetratricopeptide repeat protein 33 OS=Homo sapiens OX=9606 GN=TTC33 PE=1 SV=2" "0.000" "False" "10.280" "8" "2" "3" "2" "262" "29.4" "5.44" "7.89" "2" "" "" "" "" "23548" "ENSG00000113638" "TTC33" "B2R6G0; hsa:23548; O95105; Q6PID6" "" "" "0" "0" "1.211" "1.055" "1.185" "1.120" "1.137" "1.062" "1.225" "1.182" "1.199" "112.1" "135.8" "118.2" "132.8" "125.5" "127.4" "119.0" "137.3" "132.4" "134.3" "" "" "" "" "" "" "" "" "" "" "90.0" "98.0" "93.9" "89.0" "86.8" "95.6" "83.4" "100.3" "132.4" "109.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-948672987785726372" "False" "High" "IsMasterProtein" "Q9BT25" "HAUS augmin-like complex subunit 8 OS=Homo sapiens OX=9606 GN=HAUS8 PE=1 SV=3" "0.000" "False" "10.272" "7" "3" "3" "3" "410" "44.8" "7.06" "8.98" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "93323" "ENSG00000131351" "HAUS8" "B4DJA7; C9JBZ4; hsa:93323; Q49AC4; Q86WF0; Q96FX3; Q9BT25" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "0.988" "0.994" "1.055" "1.073" "1.004" "1.020" "1.016" "1.036" "1.041" "326.6" "322.5" "324.6" "344.4" "350.4" "328.0" "333.1" "331.8" "338.3" "340.1" "" "" "" "" "" "" "" "" "" "" "262.3" "232.7" "257.8" "230.7" "242.4" "246.1" "233.2" "242.3" "338.3" "276.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962045687038046175" "False" "High" "IsMasterProtein" "Q8NEC7" "Glutathione S-transferase C-terminal domain-containing protein OS=Homo sapiens OX=9606 GN=GSTCD PE=1 SV=2" "0.000" "False" "10.269" "4" "2" "2" "2" "633" "71.0" "7.78" "7.41" "2" "" "other cell component" "other molecular function" "Pf13679" "79807" "ENSG00000138780" "GSTCD" "A8K8J0; A8MVD3; H9KV97; hsa:79807; Q8NEC7; Q9H8S3" "" "Metapathway biotransformation Phase I and II" "1" "0" "1.011" "0.887" "1.069" "0.988" "0.957" "0.963" "1.041" "1.005" "0.912" "70.8" "71.6" "62.8" "75.6" "70.0" "67.8" "68.2" "73.7" "71.1" "64.5" "" "" "" "" "" "" "" "" "" "" "56.8" "51.6" "49.9" "50.7" "48.4" "50.8" "47.7" "53.8" "71.1" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2666601626281135846" "False" "High" "IsMasterProtein" "Q92551" "Inositol hexakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=IP6K1 PE=1 SV=3" "0.000" "False" "10.260" "8" "3" "4" "3" "441" "50.2" "7.24" "5.48" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "9807" "ENSG00000176095" "IP6K1" "A8K157; A8MUX4; hsa:9807; Q7L3I7; Q92551; Q96E38" "Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9020069583805455300" "False" "High" "IsMasterProtein" "O60234" "Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1" "0.000" "False" "10.250" "13" "2" "4" "1" "142" "16.8" "5.26" "9.94" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "9535" "ENSG00000130755; ENSG00000291873" "GMFG" "hsa:9535; O60234; Q6IB37" "Neutrophil degranulation" "" "1" "0" "0.914" "0.752" "0.905" "1.208" "1.163" "0.794" "0.845" "0.932" "0.969" "29.2" "26.7" "21.9" "26.4" "35.2" "33.9" "23.2" "24.6" "27.2" "28.3" "" "" "" "" "" "" "" "" "" "" "23.4" "19.2" "17.4" "17.7" "24.4" "25.4" "16.2" "18.0" "27.2" "23.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "676002530395001225" "False" "High" "IsMasterProtein" "Q14766" "Latent-transforming growth factor beta-binding protein 1 OS=Homo sapiens OX=9606 GN=LTBP1 PE=1 SV=4" "0.000" "False" "10.241" "3" "3" "3" "3" "1721" "186.7" "5.96" "5.95" "3" "signal transduction;other biological processes" "extracellular matrix;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00683, Pf07645, Pf12662" "4052" "ENSG00000049323" "LTBP1" "A1L3V1; hsa:4052; P22064; Q14766; Q53SD8; Q53SF3; Q53SG1; Q59HF7; Q8TD95" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Molecules associated with elastic fibres; TGF-beta receptor signaling activates SMADs" "Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling" "7" "0" "1.060" "0.853" "1.044" "0.977" "1.115" "0.842" "0.853" "1.121" "1.108" "45.2" "47.9" "38.5" "47.1" "44.1" "50.3" "38.0" "38.5" "50.6" "50.0" "" "" "" "" "" "" "" "" "" "" "36.3" "34.5" "30.6" "31.6" "30.5" "37.8" "26.6" "28.1" "50.6" "40.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8593610449357646347" "False" "High" "IsMasterProtein" "P0C2W1" "F-box/SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FBXO45 PE=1 SV=1" "0.000" "False" "10.200" "12" "3" "3" "3" "286" "30.6" "7.83" "3.77" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf12937" "200933" "ENSG00000174013" "FBXO45" "A6NF90; D3DXB5; hsa:200933; P0C2W1" "" "3q29 copy number variation syndrome" "1" "0" "1.280" "1.261" "1.297" "1.484" "1.196" "1.449" "1.353" "1.882" "1.431" "202.7" "259.5" "255.6" "263.0" "300.8" "242.5" "293.7" "274.3" "381.4" "290.1" "" "" "" "" "" "" "" "" "" "" "162.8" "187.3" "203.1" "176.2" "208.0" "181.9" "205.6" "200.3" "381.4" "236.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104257487773187704" "False" "High" "IsMasterProtein" "Q0PNE2" "Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1" "0.000" "False" "10.193" "10" "3" "3" "3" "266" "29.8" "6.84" "8.28" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf09807" "54859" "ENSG00000163832" "ELP6" "hsa:54859; Q0PNE2; Q9BW57; Q9NXJ3" "HATs acetylate histones" "" "1" "0" "1.034" "1.000" "1.204" "1.071" "1.093" "1.115" "1.218" "1.101" "0.911" "182.5" "188.6" "182.5" "219.7" "195.5" "199.4" "203.5" "222.3" "200.8" "166.2" "" "" "" "" "" "" "" "" "" "" "146.6" "136.1" "145.0" "147.2" "135.2" "149.6" "142.5" "162.4" "200.8" "135.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8727669707947595879" "False" "High" "IsMasterProtein" "Q15058" "Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1" "0.000" "False" "10.190" "2" "2" "2" "2" "1648" "186.4" "7.91" "8.10" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf16183" "9928" "ENSG00000118193" "KIF14" "hsa:9928; Q14CI8; Q15058; Q4G0A5; Q5T1W3" "RND2 GTPase cycle; RND1 GTPase cycle; RHO GTPases activate CIT" "" "3" "0" "1.156" "1.027" "1.214" "1.122" "1.127" "1.136" "1.067" "0.955" "1.054" "166.3" "192.2" "170.8" "201.8" "186.7" "187.5" "188.9" "177.4" "158.8" "175.3" "" "" "" "" "" "" "" "" "" "" "133.6" "138.7" "135.6" "135.2" "129.1" "140.7" "132.3" "129.5" "158.8" "142.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2858962051142088186" "False" "High" "IsMasterProtein" "Q8WXE1" "ATR-interacting protein OS=Homo sapiens OX=9606 GN=ATRIP PE=1 SV=1" "0.000" "False" "10.140" "4" "3" "7" "3" "791" "85.8" "6.32" "19.67" "3" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "" "84126" "ENSG00000164053" "ATRIP" "A8K6A3; A8K714; B2RCE7; B4DU92; B5MEB7; hsa:84126; Q69YK9; Q8NHQ2; Q8WUG7; Q8WXE1; Q96CL3; Q9HA30" "Processing of DNA double-strand break ends; Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "11" "0" "1.118" "1.002" "1.137" "1.023" "0.991" "1.050" "1.045" "1.059" "1.058" "652.3" "729.1" "653.4" "742.0" "667.6" "646.2" "684.8" "681.6" "690.7" "690.0" "" "" "" "" "" "" "" "" "" "" "523.9" "526.1" "519.1" "497.1" "461.7" "484.8" "479.4" "497.8" "690.7" "561.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8383359941094889164" "False" "High" "IsMasterProtein" "Q9NV35" "Nucleotide triphosphate diphosphatase NUDT15 OS=Homo sapiens OX=9606 GN=NUDT15 PE=1 SV=1" "0.000" "False" "10.129" "18" "3" "4" "3" "164" "18.6" "6.14" "11.56" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00293" "55270" "ENSG00000136159" "NUDT15" "A2RUR6; hsa:55270; Q32Q27; Q6P2C9; Q9NV35" "Azathioprine ADME; Phosphate bond hydrolysis by NUDT proteins" "" "2" "0" "1.033" "0.984" "0.972" "1.019" "0.913" "0.914" "0.957" "0.980" "1.000" "407.2" "420.8" "400.8" "395.6" "414.9" "371.7" "372.2" "389.7" "399.1" "407.1" "" "" "" "" "" "" "" "" "" "" "327.1" "303.7" "318.3" "265.1" "287.0" "278.9" "260.6" "284.6" "399.1" "331.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2632668230264232030" "False" "High" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "0.000" "False" "10.117" "41" "4" "5" "3" "79" "9.7" "8.94" "15.50" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "Small cell lung cancer" "3" "1" "0.991" "1.059" "1.045" "1.060" "1.131" "0.941" "1.015" "1.005" "1.005" "841.8" "834.1" "891.1" "879.7" "892.2" "951.7" "792.1" "854.3" "846.3" "845.9" "" "" "" "" "" "" "" "" "" "" "676.1" "601.9" "707.8" "589.4" "617.0" "714.0" "554.6" "623.9" "846.3" "687.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "131249650055906884" "False" "High" "IsMasterProtein" "O95235" "Kinesin-like protein KIF20A OS=Homo sapiens OX=9606 GN=KIF20A PE=1 SV=1" "0.000" "False" "10.115" "2" "1" "1" "1" "890" "100.2" "6.92" "4.52" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "10112" "ENSG00000112984" "KIF20A" "B4DL79; D3DQB6; hsa:10112; O95235" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis" "" "4" "0" "0.978" "0.830" "1.052" "1.131" "0.954" "0.768" "0.754" "0.652" "0.935" "96.3" "94.3" "80.0" "101.3" "108.9" "91.9" "73.9" "72.7" "62.8" "90.0" "" "" "" "" "" "" "" "" "" "" "77.4" "68.0" "63.5" "67.9" "75.3" "69.0" "51.8" "53.1" "62.8" "73.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657914547001490376" "False" "High" "IsMasterProtein" "P53778" "Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3" "0.000" "False" "10.112" "8" "2" "2" "2" "367" "41.9" "6.39" "6.39" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6300" "ENSG00000188130" "MAPK12" "hsa:6300; P53778; Q14260; Q6IC53; Q99588; Q99672" "VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Negative regulation of MAPK pathway" "Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway" "30" "0" "0.972" "0.922" "0.969" "1.023" "0.967" "0.983" "0.997" "0.967" "0.965" "284.0" "276.1" "261.9" "275.2" "290.4" "274.6" "279.2" "283.1" "274.6" "274.1" "" "" "" "" "" "" "" "" "" "" "228.1" "199.2" "208.1" "184.4" "200.8" "206.0" "195.5" "206.8" "274.6" "222.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "783704005019212775" "False" "High" "IsMasterProtein" "Q8IZ21" "Phosphatase and actin regulator 4 OS=Homo sapiens OX=9606 GN=PHACTR4 PE=1 SV=1" "0.000" "False" "10.105" "6" "3" "3" "3" "702" "78.2" "6.62" "8.83" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf02755" "65979" "ENSG00000204138" "PHACTR4" "A2APK6; B9ZVW0; D3DPM3; hsa:65979; Q68DD4; Q6NUN6; Q8IZ21; Q8N384; Q9H395; Q9H6X0; Q9H8W6" "" "" "0" "0" "1.033" "1.118" "1.307" "1.234" "1.094" "1.022" "0.997" "0.966" "1.357" "54.0" "55.8" "60.3" "70.6" "66.6" "59.1" "55.2" "53.8" "52.1" "73.2" "" "" "" "" "" "" "" "" "" "" "43.4" "40.2" "47.9" "47.3" "46.1" "44.3" "38.6" "39.3" "52.1" "59.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8275820454411589683" "False" "High" "IsMasterProtein" "Cont_P41361" "Antithrombin-III OS=Bos taurus OX=9913 GN=SERPINC1 PE=1 SV=2" "0.000" "True" "10.097" "7" "3" "3" "3" "465" "52.3" "7.33" "8.93" "3" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00079" "540261" "" "SERPINC1" "bta:540261; P41361; Q3SZQ7" "" "" "0" "0" "0.961" "0.946" "1.064" "0.935" "1.088" "1.321" "1.017" "1.030" "1.104" "235.7" "226.4" "222.9" "250.9" "220.3" "256.4" "311.4" "239.8" "242.8" "260.3" "" "" "" "" "" "" "" "" "" "" "189.3" "163.4" "177.0" "168.1" "152.4" "192.4" "218.1" "175.1" "242.8" "211.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8775799832689222428" "False" "High" "IsMasterProtein" "Q8IV38" "Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1" "0.000" "False" "10.087" "5" "1" "1" "1" "441" "49.3" "6.25" "5.14" "1" "" "other cell component" "other molecular function" "Pf01753, Pf12796" "57037" "ENSG00000106524" "ANKMY2" "A4D124; hsa:57037; Q659G1; Q8IV38; Q96BL3" "" "" "0" "0" "1.045" "1.087" "1.133" "1.099" "1.327" "1.078" "0.929" "1.109" "1.408" "36.0" "37.6" "39.1" "40.8" "39.5" "47.8" "38.8" "33.4" "39.9" "50.7" "" "" "" "" "" "" "" "" "" "" "28.9" "27.1" "31.1" "27.3" "27.4" "35.8" "27.2" "24.4" "39.9" "41.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5401388015032906251" "False" "High" "IsMasterProtein" "O95402" "Mediator of RNA polymerase II transcription subunit 26 OS=Homo sapiens OX=9606 GN=MED26 PE=1 SV=2" "0.000" "False" "10.084" "6" "3" "4" "3" "600" "65.4" "9.16" "10.90" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08711, Pf15693, Pf15694" "9441" "ENSG00000105085" "MED26" "A1A4S3; hsa:9441; O95402; Q0VGB6" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "0.987" "0.918" "1.043" "0.890" "1.022" "0.969" "1.028" "1.011" "0.806" "30.7" "30.3" "28.2" "32.1" "27.4" "31.4" "29.8" "31.6" "31.1" "24.8" "" "" "" "" "" "" "" "" "" "" "24.7" "21.9" "22.4" "21.5" "18.9" "23.6" "20.8" "23.1" "31.1" "20.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5948729275611586048" "False" "High" "IsMasterProtein" "Q70IA6" "MOB kinase activator 2 OS=Homo sapiens OX=9606 GN=MOB2 PE=1 SV=1" "0.000" "False" "10.079" "11" "3" "3" "3" "237" "26.9" "6.79" "10.54" "3" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "81532" "ENSG00000182208; ENSG00000291442" "MOB2" "B4DKP3; hsa:81532; Q70IA6; Q96M67" "" "" "0" "0" "1.100" "1.118" "1.104" "1.080" "1.094" "0.950" "1.046" "0.997" "1.188" "89.7" "98.7" "100.3" "99.0" "96.9" "98.1" "85.2" "93.8" "89.5" "106.6" "" "" "" "" "" "" "" "" "" "" "72.0" "71.2" "79.7" "66.3" "67.0" "73.6" "59.6" "68.5" "89.5" "86.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243679290783972836" "False" "High" "IsMasterProtein" "Q5JPE7" "BOS complex subunit NOMO2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1" "0.000" "False" "10.050" "1" "2" "3" "2" "1267" "139.4" "5.76" "10.02" "2" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity;other molecular function" "Pf13620, Pf17802" "283820" "ENSG00000185164" "NOMO2" "hsa:283820; Q4G177; Q5JPE7" "" "" "0" "0" "0.947" "0.940" "1.073" "0.978" "0.977" "0.981" "1.074" "1.068" "1.029" "309.8" "293.3" "291.2" "332.3" "303.1" "302.7" "304.0" "332.8" "330.8" "318.8" "" "" "" "" "" "" "" "" "" "" "248.8" "211.6" "231.3" "222.6" "209.6" "227.1" "212.8" "243.0" "330.8" "259.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7557480247223307302" "False" "High" "IsMasterProtein" "O94806" "Serine/threonine-protein kinase D3 OS=Homo sapiens OX=9606 GN=PRKD3 PE=1 SV=1" "0.000" "False" "10.048" "3" "2" "2" "1" "890" "100.4" "6.87" "7.26" "2" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00169" "23683" "ENSG00000115825" "PRKD3" "D6W587; hsa:23683; O94806; Q53TR7; Q8NEL8" "Sphingolipid de novo biosynthesis" "G protein signaling pathways; Hippo signaling regulation pathways; Chronic hyperglycemia impairment of neuron function" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-331948696601358906" "False" "High" "IsMasterProtein" "Q969T7" "7-methylguanosine phosphate-specific 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C3B PE=1 SV=4" "0.000" "False" "10.002" "11" "4" "5" "4" "300" "34.4" "6.38" "15.01" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf05822" "115024" "ENSG00000141698" "NT5C3B" "A8MWB9; C9JKC4; hsa:115024; Q7L3B7; Q969T7" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "0.977" "0.953" "1.004" "1.031" "0.987" "0.951" "0.974" "0.980" "0.960" "413.7" "404.0" "394.1" "415.5" "426.7" "408.5" "393.5" "402.8" "405.6" "397.1" "" "" "" "" "" "" "" "" "" "" "332.3" "291.5" "313.0" "278.4" "295.1" "306.5" "275.5" "294.2" "405.6" "323.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415946790012265046" "False" "High" "IsMasterProtein" "O75586" "Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2" "0.000" "False" "9.992" "11" "3" "4" "3" "246" "28.4" "8.62" "11.42" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04934" "10001" "ENSG00000133997" "MED6" "B4DU17; B4E2P0; hsa:10001; O15401; O75586; Q53FE3; Q53HJ3; Q6FHQ4; Q9BTH1; Q9UHL1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "0.934" "0.998" "1.049" "0.931" "0.879" "0.926" "1.024" "1.016" "0.912" "243.3" "227.1" "242.7" "255.3" "226.4" "213.9" "225.2" "249.0" "247.3" "221.9" "" "" "" "" "" "" "" "" "" "" "195.4" "163.9" "192.8" "171.1" "156.6" "160.5" "157.7" "181.9" "247.3" "180.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2203431477329866008" "False" "High" "IsMasterProtein" "Q9BZK3" "Putative nascent polypeptide-associated complex subunit alpha-like protein OS=Homo sapiens OX=9606 GN=NACA4P PE=5 SV=1" "0.000" "False" "9.985" "13" "2" "8" "1" "213" "23.3" "4.59" "15.50" "2" "other biological processes" "translational apparatus;other cell component" "other molecular function" "Pf01849" "" "" "NACA4P" "Q9BZK3" "" "" "0" "0" "1.010" "0.979" "1.145" "0.932" "0.981" "1.052" "1.055" "1.008" "1.034" "57.2" "57.8" "56.0" "65.5" "53.3" "56.1" "60.2" "60.3" "57.7" "59.1" "" "" "" "" "" "" "" "" "" "" "45.9" "41.7" "44.5" "43.9" "36.8" "42.1" "42.1" "44.0" "57.7" "48.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4655798141038654615" "False" "High" "IsMasterProtein" "Q8N6N3" "UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1" "0.000" "False" "9.958" "12" "2" "4" "2" "182" "20.6" "5.21" "11.02" "2" "" "nucleus" "" "Pf15559" "148423" "ENSG00000162642" "C1orf52" "B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6" "" "" "0" "0" "1.222" "1.144" "1.074" "1.082" "1.175" "1.190" "1.140" "1.066" "1.248" "63.1" "77.1" "72.2" "67.8" "68.3" "74.1" "75.1" "72.0" "67.3" "78.8" "" "" "" "" "" "" "" "" "" "" "50.7" "55.7" "57.4" "45.4" "47.2" "55.6" "52.6" "52.6" "67.3" "64.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "400708693502021351" "False" "High" "IsMasterProtein" "Q12857" "Nuclear factor 1 A-type OS=Homo sapiens OX=9606 GN=NFIA PE=1 SV=2" "0.000" "False" "9.953" "5" "3" "3" "3" "509" "55.9" "8.44" "9.39" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4774" "ENSG00000162599" "NFIA" "B4DRJ3; B4DS53; F5H0R0; F8W8W3; hsa:4774; Q12857; Q8TA97; Q9H3X9; Q9P2A9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "" "2" "0" "1.160" "1.211" "1.058" "1.036" "1.046" "1.016" "1.068" "1.026" "0.919" "66.1" "76.7" "80.1" "70.0" "68.5" "69.2" "67.2" "70.6" "67.9" "60.8" "" "" "" "" "" "" "" "" "" "" "53.1" "55.4" "63.6" "46.9" "47.4" "51.9" "47.1" "51.6" "67.9" "49.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1753263337049179801" "False" "High" "IsMasterProtein" "O75808" "Calpain-15 OS=Homo sapiens OX=9606 GN=CAPN15 PE=1 SV=1" "0.000" "False" "9.927" "2" "1" "1" "1" "1086" "117.2" "6.71" "4.64" "1" "protein metabolism" "other cell component" "other molecular function" "Pf00641, Pf00648" "6650" "ENSG00000103326" "CAPN15" "B1B1M4; hsa:6650; O75808; Q2KHS2; Q8WTY9; Q9BUW0" "Degradation of the extracellular matrix" "" "1" "0" "0.702" "0.937" "1.289" "0.811" "0.896" "1.160" "0.794" "0.981" "1.061" "33.5" "23.6" "31.4" "43.2" "27.2" "30.1" "38.9" "26.6" "32.9" "35.6" "" "" "" "" "" "" "" "" "" "" "26.9" "17.0" "25.0" "29.0" "18.8" "22.6" "27.2" "19.4" "32.9" "28.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1035023352736906795" "False" "High" "IsMasterProtein" "O00399" "Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1" "0.000" "False" "9.907" "24" "5" "7" "5" "190" "20.7" "6.32" "14.84" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "10671" "ENSG00000104671" "DCTN6" "B2RAC1; hsa:10671; O00399" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "Vasopressin-regulated water reabsorption" "5" "0" "0.960" "1.050" "1.025" "1.137" "1.054" "1.115" "1.057" "1.084" "1.015" "738.0" "708.3" "775.2" "756.7" "838.9" "777.5" "822.5" "779.9" "800.0" "749.1" "" "" "" "" "" "" "" "" "" "" "592.7" "511.1" "615.8" "507.0" "580.2" "583.3" "575.9" "569.6" "800.0" "609.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120787877776140146" "False" "High" "IsMasterProtein" "Q17RS7" "Flap endonuclease GEN homolog 1 OS=Homo sapiens OX=9606 GN=GEN1 PE=1 SV=2" "0.000" "False" "9.905" "4" "2" "2" "2" "908" "102.8" "7.81" "7.31" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867, Pf18704" "348654" "ENSG00000178295" "GEN1" "hsa:348654; Q17RS7; Q17RS9; Q6ZN37" "Resolution of D-loop Structures through Holliday Junction Intermediates" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7563735417890983721" "False" "High" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "0.000" "False" "9.901" "16" "2" "2" "2" "172" "19.7" "5.00" "7.28" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400; ENSG00000292191" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Recruitment of NuMA to mitotic centrosomes; SUMOylation of DNA damage response and repair proteins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "0" "1.111" "0.929" "1.004" "1.172" "1.221" "0.955" "1.087" "1.124" "0.996" "126.4" "140.5" "117.5" "126.9" "148.1" "154.4" "120.7" "137.5" "142.1" "125.9" "" "" "" "" "" "" "" "" "" "" "101.5" "101.4" "93.3" "85.0" "102.4" "115.8" "84.5" "100.4" "142.1" "102.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3953931010856732739" "False" "High" "IsMasterProtein" "P16104" "Histone H2AX OS=Homo sapiens OX=9606 GN=H2AX PE=1 SV=2" "0.000" "False" "9.893" "27" "5" "10" "2" "143" "15.1" "10.74" "23.14" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "3014" "ENSG00000188486" "H2AX" "hsa:3014; P16104; Q4ZGJ7; Q6IAS5" "Amyloid fiber formation; Meiotic synapsis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Proteasome degradation; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DNA repair pathways, full network; 5q35 copy number variation; DNA damage response" "47" "3" "0.964" "1.075" "1.206" "1.109" "1.100" "1.223" "1.004" "1.061" "1.075" "777.4" "749.4" "836.1" "937.7" "862.2" "855.5" "950.4" "780.6" "825.2" "836.0" "" "" "" "" "" "" "" "" "" "" "624.4" "540.8" "664.1" "628.2" "596.3" "641.9" "665.4" "570.1" "825.2" "679.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6863710948507417354" "False" "High" "IsMasterProtein" "Q9P2J3" "Kelch-like protein 9 OS=Homo sapiens OX=9606 GN=KLHL9 PE=1 SV=2" "0.000" "False" "9.879" "4" "2" "2" "2" "617" "69.4" "6.35" "7.04" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "55958" "ENSG00000198642" "KLHL9" "hsa:55958; Q8TCQ2; Q9P2J3" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.844" "0.886" "1.025" "1.134" "1.023" "0.882" "1.054" "0.973" "1.147" "93.6" "79.0" "82.9" "95.9" "106.2" "95.8" "82.5" "98.6" "91.1" "107.3" "" "" "" "" "" "" "" "" "" "" "75.2" "57.0" "65.8" "64.2" "73.4" "71.9" "57.8" "72.0" "91.1" "87.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053349268782207138" "False" "High" "IsMasterProtein" "Q8IYR2" "SET and MYND domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SMYD4 PE=1 SV=3" "0.000" "False" "9.870" "4" "3" "3" "3" "804" "89.2" "6.83" "6.10" "3" "other metabolic processes;developmental processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf01753" "114826" "ENSG00000186532" "SMYD4" "hsa:114826; Q8IYR2; Q8N1P2; Q8NAT0; Q96LV4; Q96PV2" "" "Histone modifications" "1" "0" "0.945" "0.917" "0.865" "0.941" "0.951" "0.833" "0.799" "0.823" "0.832" "220.6" "208.4" "202.3" "190.9" "207.7" "209.9" "183.7" "176.4" "181.5" "183.5" "" "" "" "" "" "" "" "" "" "" "177.2" "150.4" "160.7" "127.9" "143.6" "157.4" "128.6" "128.8" "181.5" "149.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853825877774435955" "False" "High" "IsMasterProtein" "Q96HQ2" "CDKN2AIP N-terminal-like protein OS=Homo sapiens OX=9606 GN=CDKN2AIPNL PE=1 SV=1" "0.000" "False" "9.857" "25" "2" "2" "2" "116" "13.2" "5.00" "6.04" "2" "" "" "" "Pf11952" "91368" "ENSG00000237190" "CDKN2AIPNL" "hsa:91368; Q8WVE3; Q96HQ2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2458914006646188126" "False" "High" "IsMasterProtein" "Q9NYV6" "RNA polymerase I-specific transcription initiation factor RRN3 OS=Homo sapiens OX=9606 GN=RRN3 PE=1 SV=1" "0.000" "False" "9.854" "2" "1" "1" "1" "651" "74.1" "5.63" "5.44" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf05327" "54700" "ENSG00000085721; ENSG00000278494" "RRN3" "A2RTY9; B4E0J7; B4E3T2; hsa:54700; Q3MHU9; Q6IPL4; Q9H4F0; Q9NYV6" "RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape" "" "2" "0" "1.026" "0.929" "0.940" "0.827" "0.924" "0.815" "0.882" "0.922" "0.939" "272.6" "279.6" "253.3" "256.2" "225.4" "251.9" "222.2" "240.6" "251.4" "256.1" "" "" "" "" "" "" "" "" "" "" "219.0" "201.8" "201.2" "171.6" "155.9" "189.0" "155.6" "175.7" "251.4" "208.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1940772277811891477" "False" "High" "IsMasterProtein" "Q96PM5" "RING finger and CHY zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCHY1 PE=1 SV=1" "0.000" "False" "9.854" "9" "2" "2" "2" "261" "30.1" "6.71" "7.90" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05495, Pf13639, Pf14599" "25898" "ENSG00000163743" "RCHY1" "B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PM5; Q96PR5" "Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH" "Measles virus infection" "3" "0" "1.105" "1.164" "1.106" "1.249" "0.977" "1.037" "1.177" "1.182" "1.036" "156.0" "172.4" "181.5" "172.5" "194.8" "152.4" "161.8" "183.6" "184.3" "161.5" "" "" "" "" "" "" "" "" "" "" "125.3" "124.4" "144.2" "115.6" "134.7" "114.3" "113.2" "134.1" "184.3" "131.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157541479094675987" "False" "High" "IsMasterProtein" "Q96AB3" "Isochorismatase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ISOC2 PE=1 SV=1" "0.000" "False" "9.850" "18" "2" "2" "2" "205" "22.3" "7.77" "7.84" "2" "other biological processes" "nucleus;other cell component" "" "Pf00857" "79763" "ENSG00000063241" "ISOC2" "hsa:79763; Q6ZN91; Q96AB3; Q9H5G0" "" "" "0" "0" "0.876" "0.740" "0.807" "0.915" "0.825" "0.891" "0.758" "0.789" "0.835" "194.0" "170.0" "143.5" "156.5" "177.6" "160.0" "172.9" "147.1" "153.0" "162.1" "" "" "" "" "" "" "" "" "" "" "155.9" "122.7" "114.0" "104.9" "122.8" "120.1" "121.0" "107.4" "153.0" "131.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8713380436033100522" "False" "High" "IsMasterProtein" "Q71SY5" "Mediator of RNA polymerase II transcription subunit 25 OS=Homo sapiens OX=9606 GN=MED25 PE=1 SV=2" "0.000" "False" "9.848" "5" "4" "4" "4" "747" "78.1" "8.34" "9.09" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11232, Pf11235, Pf11265" "81857" "ENSG00000104973" "MED25" "A8K095; B9TX30; hsa:81857; O95783; Q6P143; Q6QMH5; Q707U4; Q71SY5; Q8TB55; Q9H0L5; Q9HB34" "PPARA activates gene expression; Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "4" "0" "0.984" "1.006" "1.145" "1.091" "0.992" "1.033" "1.066" "0.944" "1.031" "172.3" "169.6" "173.3" "197.2" "188.0" "170.9" "178.0" "183.8" "162.7" "177.6" "" "" "" "" "" "" "" "" "" "" "138.4" "122.4" "137.7" "132.1" "130.0" "128.2" "124.6" "134.2" "162.7" "144.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1448578471139674410" "False" "High" "IsMasterProtein" "Q6PJ69" "E3 ubiquitin-protein ligase TRIM65 OS=Homo sapiens OX=9606 GN=TRIM65 PE=1 SV=3" "0.000" "False" "9.824" "7" "3" "4" "3" "517" "57.3" "6.70" "10.20" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf00622, Pf00643" "201292" "ENSG00000141569" "TRIM65" "hsa:201292; Q4G0F0; Q6DKJ6; Q6PJ69; Q9BRP6" "" "" "0" "0" "1.011" "0.988" "0.979" "0.972" "0.992" "0.898" "0.942" "0.980" "1.101" "551.1" "557.2" "544.3" "539.7" "535.6" "546.7" "494.6" "519.4" "540.1" "606.9" "" "" "" "" "" "" "" "" "" "" "442.6" "402.1" "432.4" "361.6" "370.4" "410.2" "346.3" "379.3" "540.1" "493.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7106533515535511067" "False" "High" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "0.000" "False" "9.820" "10" "2" "3" "2" "191" "20.9" "4.39" "11.41" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "1.077" "1.014" "1.176" "1.018" "1.037" "1.119" "1.124" "1.142" "1.159" "334.8" "360.5" "339.6" "393.9" "340.9" "347.2" "374.6" "376.5" "382.3" "388.2" "" "" "" "" "" "" "" "" "" "" "268.9" "260.1" "269.8" "263.9" "235.8" "260.5" "262.3" "274.9" "382.3" "315.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8237731062455566207" "False" "High" "IsMasterProtein" "P40763" "Signal transducer and activator of transcription 3 OS=Homo sapiens OX=9606 GN=STAT3 PE=1 SV=2" "0.000" "False" "9.815" "3" "2" "2" "2" "770" "88.0" "6.30" "7.54" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6774" "ENSG00000168610" "STAT3" "A8K7B8; hsa:6774; K7ENL3; O14916; P40763; Q9BW54" "Interleukin-4 and Interleukin-13 signaling; Transcriptional regulation of granulopoiesis; Senescence-Associated Secretory Phenotype (SASP); PKR-mediated signaling; Signaling by ALK fusions and activated point mutants; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by ALK; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-10 signaling; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; PTK6 Activates STAT3; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; STAT3 nuclear events downstream of ALK signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-23 signaling; Interleukin-27 signaling; Interleukin-37 signaling; Signalling to STAT3; Nuclear events stimulated by ALK signaling in cancer; MET activates STAT3; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "IL-5 signaling pathway; Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Involution (Stage 4 of 4); Dopaminergic neurogenesis; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Estrogen receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Development of pulmonary dendritic cells and macrophage subsets; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Leptin-insulin signaling overlap; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Clear cell renal cell carcinoma pathways; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Extracellular vesicles in the crosstalk of cardiac cells; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Inflammatory bowel disease signaling; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Notch signaling pathway; Serotonin HTR1 group and FOS pathway" "119" "0" "1.110" "1.174" "1.368" "1.164" "1.098" "1.432" "1.211" "1.225" "1.458" "108.9" "120.9" "127.9" "148.9" "126.7" "119.5" "156.0" "131.8" "133.3" "158.7" "" "" "" "" "" "" "" "" "" "" "87.5" "87.2" "101.6" "99.8" "87.6" "89.7" "109.2" "96.3" "133.3" "129.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4329245545062110439" "False" "High" "IsMasterProtein" "Q9NQ50" "Large ribosomal subunit protein mL40 OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1" "0.000" "False" "9.812" "7" "1" "2" "1" "206" "24.5" "9.63" "10.16" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf09812" "64976" "ENSG00000185608" "MRPL40" "B3KVZ7; hsa:64976; O95134; Q9NQ50" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "22q11.2 copy number variation syndrome" "4" "0" "0.987" "1.068" "0.878" "1.113" "0.922" "1.010" "1.003" "0.832" "1.041" "76.7" "75.7" "81.9" "67.3" "85.4" "70.8" "77.5" "77.0" "63.9" "79.9" "" "" "" "" "" "" "" "" "" "" "61.6" "54.6" "65.1" "45.1" "59.1" "53.1" "54.3" "56.2" "63.9" "65.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5356440792729817096" "False" "High" "IsMasterProtein" "Q5VZ89" "DENN domain-containing protein 4C OS=Homo sapiens OX=9606 GN=DENND4C PE=1 SV=3" "0.000" "False" "9.812" "1" "2" "2" "2" "1909" "212.6" "6.83" "7.74" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "55667" "ENSG00000137145" "DENND4C" "A2A3R1; A2A3R2; A2A3R3; A2A3R9; hsa:55667; Q5VZ89; Q6AI48; Q6ZUB3; Q8NCY7; Q9H6N4; Q9NUT1; Q9NWA5; Q9NWT3; R4GN35; R4GNB2" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.040" "0.997" "1.166" "0.946" "0.994" "0.995" "0.988" "0.916" "0.973" "197.1" "204.9" "196.5" "229.7" "186.4" "196.0" "196.0" "194.6" "180.4" "191.8" "" "" "" "" "" "" "" "" "" "" "158.3" "147.8" "156.1" "153.9" "128.9" "147.0" "137.2" "142.1" "180.4" "156.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5478644363893045592" "False" "High" "IsMasterProtein" "P60002" "Transcription elongation factor 1 homolog OS=Homo sapiens OX=9606 GN=ELOF1 PE=1 SV=1" "0.000" "False" "9.812" "22" "1" "2" "1" "83" "9.5" "8.00" "7.58" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf05129" "84337" "ENSG00000130165" "ELOF1" "hsa:84337; P60002; Q8R1J7; Q96II4" "" "" "0" "0" "0.949" "0.896" "0.984" "1.064" "1.031" "1.043" "0.985" "1.109" "0.987" "89.7" "85.2" "80.4" "88.3" "95.5" "92.5" "93.6" "88.4" "99.5" "88.6" "" "" "" "" "" "" "" "" "" "" "72.1" "61.5" "63.9" "59.2" "66.0" "69.4" "65.5" "64.5" "99.5" "72.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7159036767897580858" "False" "High" "IsMasterProtein" "P20036" "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" "0.000" "False" "9.807" "7" "2" "2" "2" "260" "29.4" "5.21" "7.70" "2" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00993, Pf07654" "3113" "ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177" "HLA-DPA1" "A9YWH7; B9UKH4; O19722; O46883; P01905; P20036; P79554; Q2Q060; Q2Q061; Q5EY03; Q5STP1; Q6DQK4; Q9BCQ1; Q9TPX3; Q9XS10" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host" "9" "0" "0.905" "0.940" "0.897" "1.018" "1.001" "1.070" "0.960" "0.929" "1.041" "510.4" "461.8" "479.6" "457.9" "519.7" "511.0" "546.2" "490.1" "474.2" "531.5" "" "" "" "" "" "" "" "" "" "" "409.9" "333.2" "381.0" "306.8" "359.4" "383.4" "382.4" "357.9" "474.2" "432.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4052352701498406510" "False" "High" "IsMasterProtein" "Q9Y6J9" "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens OX=9606 GN=TAF6L PE=1 SV=1" "0.000" "False" "9.793" "5" "3" "3" "3" "622" "67.8" "8.97" "9.35" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "10629" "ENSG00000162227" "TAF6L" "B2RAT0; hsa:10629; Q96HA6; Q9Y6J9" "HATs acetylate histones" "" "1" "0" "1.065" "1.026" "1.113" "1.225" "1.126" "1.233" "1.213" "1.117" "1.227" "173.2" "184.4" "177.7" "192.8" "212.2" "195.1" "213.6" "210.1" "193.4" "212.4" "" "" "" "" "" "" "" "" "" "" "139.1" "133.0" "141.1" "129.2" "146.7" "146.4" "149.6" "153.4" "193.4" "172.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7756363839167913105" "False" "High" "IsMasterProtein" "Q13490" "Baculoviral IAP repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=BIRC2 PE=1 SV=2" "0.000" "False" "9.775" "3" "1" "2" "1" "618" "69.9" "6.70" "6.78" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00653, Pf13920, Pf21290" "329" "ENSG00000110330" "BIRC2" "B4E026; hsa:329; Q13490; Q16516; Q4TTG0" "Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; Regulation of necroptotic cell death; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Apoptotic cleavage of cellular proteins" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Apoptosis; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; Photodynamic therapy-induced NF-kB survival signaling; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma" "22" "0" "1.045" "0.924" "0.825" "1.385" "0.929" "0.956" "0.963" "0.897" "0.795" "21.4" "22.4" "19.8" "17.7" "29.7" "19.9" "20.5" "20.6" "19.2" "17.0" "" "" "" "" "" "" "" "" "" "" "17.2" "16.2" "15.7" "11.8" "20.5" "14.9" "14.4" "15.1" "19.2" "13.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832536973652725080" "False" "High" "IsMasterProtein" "Q96C90" "Protein phosphatase 1 regulatory subunit 14B OS=Homo sapiens OX=9606 GN=PPP1R14B PE=1 SV=3" "0.000" "False" "9.756" "17" "2" "3" "2" "147" "15.9" "4.86" "11.13" "2" "stress response;other biological processes" "other cell component" "enzyme regulator activity" "Pf05361" "26472" "ENSG00000173457" "PPP1R14B" "hsa:26472; Q504S7; Q7KZD7; Q96C90" "" "" "0" "0" "1.185" "1.713" "1.540" "1.762" "1.564" "1.764" "1.746" "1.435" "1.865" "18.3" "21.7" "31.3" "28.1" "32.2" "28.6" "32.2" "31.9" "26.2" "34.1" "" "" "" "" "" "" "" "" "" "" "14.7" "15.6" "24.9" "18.9" "22.3" "21.4" "22.6" "23.3" "26.2" "27.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758038755542979545" "False" "High" "IsMasterProtein" "P61769" "Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1" "0.000" "False" "9.731" "8" "1" "2" "1" "119" "13.7" "6.52" "7.45" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07654" "567" "ENSG00000166710; ENSG00000273686" "B2M" "hsa:567; P01884; P61769; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DAP12 signaling; ER-Phagosome pathway; Neutrophil degranulation; Amyloid fiber formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "IL-18 signaling pathway" "13" "0" "1.073" "1.091" "1.017" "1.109" "1.070" "1.200" "1.179" "1.210" "1.168" "262.7" "281.8" "286.5" "267.1" "291.2" "281.0" "315.1" "309.8" "317.9" "306.8" "" "" "" "" "" "" "" "" "" "" "211.0" "203.4" "227.5" "178.9" "201.4" "210.8" "220.6" "226.2" "317.9" "249.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-428002072210945893" "False" "High" "IsMasterProtein" "P52657" "Transcription initiation factor IIA subunit 2 OS=Homo sapiens OX=9606 GN=GTF2A2 PE=1 SV=1" "0.000" "False" "9.674" "28" "4" "4" "4" "109" "12.4" "6.62" "9.98" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02268, Pf02751" "2958" "ENSG00000140307" "GTF2A2" "A8MYQ7; hsa:2958; P52657; Q6FGB5" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "Eukaryotic transcription initiation" "11" "0" "1.056" "1.060" "1.079" "0.911" "1.002" "0.946" "0.844" "0.883" "0.966" "430.0" "454.0" "455.7" "464.2" "391.8" "430.9" "406.8" "362.8" "379.6" "415.5" "" "" "" "" "" "" "" "" "" "" "345.4" "327.6" "362.0" "311.0" "271.0" "323.3" "284.8" "265.0" "379.6" "337.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022401648324513827" "False" "High" "IsMasterProtein" "Q9H6W3" "Ribosomal oxygenase 1 OS=Homo sapiens OX=9606 GN=RIOX1 PE=1 SV=2" "0.000" "False" "9.671" "4" "2" "2" "2" "641" "71.0" "6.46" "7.51" "2" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf08007, Pf21233" "79697" "ENSG00000170468" "RIOX1" "B4DT02; hsa:79697; Q9H6W3" "Protein hydroxylation" "" "1" "0" "1.022" "1.105" "1.088" "1.163" "1.138" "1.180" "1.212" "1.111" "1.075" "177.3" "181.1" "196.0" "192.8" "206.2" "201.7" "209.2" "214.8" "197.0" "190.5" "" "" "" "" "" "" "" "" "" "" "142.4" "130.7" "155.7" "129.2" "142.6" "151.3" "146.5" "156.9" "197.0" "154.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4311553193835580120" "False" "High" "IsMasterProtein" "P56556" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFA6 PE=1 SV=4" "0.000" "False" "9.667" "21" "3" "3" "3" "128" "15.1" "9.98" "7.61" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion" "transporter activity" "Pf13233" "4700" "ENSG00000184983; ENSG00000272765; ENSG00000273397; ENSG00000277365; ENSG00000281013" "NDUFA6" "B2RE54; hsa:4700; O43675; P56556; Q6FGW0; Q6IBT8; Q6IC39" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.912" "0.971" "0.981" "0.904" "0.855" "0.982" "1.087" "0.985" "0.968" "533.9" "486.9" "518.3" "523.7" "482.4" "456.3" "524.3" "580.6" "526.2" "516.6" "" "" "" "" "" "" "" "" "" "" "428.9" "351.3" "411.7" "350.9" "333.7" "342.4" "367.1" "424.0" "526.2" "420.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8332009621871794895" "False" "High" "IsMasterProtein" "Q03933" "Heat shock factor protein 2 OS=Homo sapiens OX=9606 GN=HSF2 PE=1 SV=1" "0.000" "False" "9.664" "6" "3" "3" "2" "536" "60.3" "4.82" "7.87" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00447, Pf06546" "3298" "ENSG00000025156" "HSF2" "B4DGJ4; hsa:3298; Q03933; Q0VAH9; Q2M1K4; Q9H445" "" "" "0" "0" "0.813" "0.857" "0.764" "0.606" "0.909" "0.955" "0.591" "0.915" "0.960" "22.4" "18.2" "19.2" "17.2" "13.6" "20.4" "21.4" "13.3" "20.5" "21.5" "" "" "" "" "" "" "" "" "" "" "18.0" "13.2" "15.3" "11.5" "9.4" "15.3" "15.0" "9.7" "20.5" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "244546503464630376" "False" "High" "IsMasterProtein" "P78337" "Pituitary homeobox 1 OS=Homo sapiens OX=9606 GN=PITX1 PE=1 SV=2" "0.000" "False" "9.652" "6" "1" "1" "1" "314" "34.1" "8.98" "5.79" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf03826" "5307" "ENSG00000069011" "PITX1" "A8K3M0; D3DQB0; hsa:5307; O14677; O60425; P78337; Q9BTI5" "" "" "0" "0" "1.061" "0.936" "1.055" "1.083" "0.856" "0.929" "0.974" "1.023" "1.070" "117.4" "124.6" "109.9" "123.9" "127.2" "100.5" "109.1" "114.3" "120.1" "125.6" "" "" "" "" "" "" "" "" "" "" "94.3" "89.9" "87.3" "83.0" "88.0" "75.4" "76.4" "83.5" "120.1" "102.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586542513876721198" "False" "High" "IsMasterProtein" "O43502" "DNA repair protein RAD51 homolog 3 OS=Homo sapiens OX=9606 GN=RAD51C PE=1 SV=1" "0.000" "False" "9.645" "6" "2" "2" "2" "376" "42.2" "6.74" "6.79" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5889" "ENSG00000108384" "RAD51C" "hsa:5889; O43502; O43503; Q3B783" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination" "DNA repair pathways, full network" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653368877228174187" "False" "High" "IsMasterProtein" "Q9NRX2" "Large ribosomal subunit protein bL17m OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "0.000" "False" "9.642" "20" "4" "4" "4" "175" "20.0" "10.11" "7.68" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.932" "0.948" "0.784" "0.982" "0.978" "0.885" "0.925" "0.997" "0.964" "109.0" "101.6" "103.3" "85.4" "107.0" "106.6" "96.5" "100.8" "108.7" "105.0" "" "" "" "" "" "" "" "" "" "" "87.6" "73.3" "82.0" "57.2" "74.0" "80.0" "67.5" "73.6" "108.7" "85.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858307060055438950" "False" "High" "IsMasterProtein" "Q9HAB8" "Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2" "0.000" "False" "9.629" "10" "3" "3" "3" "311" "34.0" "6.71" "7.38" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04127" "79717" "ENSG00000127125" "PPCS" "hsa:79717; Q3KQT2; Q5VVM0; Q9HAB8" "Coenzyme A biosynthesis" "" "1" "0" "0.854" "0.799" "0.920" "0.951" "0.840" "0.903" "0.861" "0.920" "0.851" "36.7" "31.3" "29.3" "33.7" "34.9" "30.8" "33.1" "31.6" "33.8" "31.2" "" "" "" "" "" "" "" "" "" "" "29.5" "22.6" "23.3" "22.6" "24.1" "23.1" "23.2" "23.1" "33.8" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3431130476793294573" "False" "High" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "0.000" "False" "9.626" "13" "3" "5" "3" "188" "20.8" "9.66" "12.37" "3" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.162" "1.138" "1.074" "1.057" "1.004" "0.989" "1.077" "1.126" "1.082" "214.0" "248.7" "243.6" "229.9" "226.2" "214.9" "211.8" "230.5" "241.1" "231.5" "" "" "" "" "" "" "" "" "" "" "171.9" "179.5" "193.5" "154.0" "156.4" "161.2" "148.3" "168.3" "241.1" "188.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811963604537530771" "False" "High" "IsMasterProtein" "Q96S15" "GATOR2 complex protein WDR24 OS=Homo sapiens OX=9606 GN=WDR24 PE=1 SV=2" "0.000" "False" "9.622" "3" "2" "2" "2" "790" "88.2" "6.52" "7.05" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "84219" "ENSG00000127580" "WDR24" "A2IDB8; D3DU59; hsa:84219; Q96GC7; Q96S15; Q9H0B7" "Amino acids regulate mTORC1" "" "1" "0" "0.868" "1.008" "1.011" "1.079" "0.940" "0.806" "0.801" "1.062" "0.993" "40.6" "35.3" "40.9" "41.1" "43.8" "38.2" "32.8" "32.6" "43.1" "40.3" "" "" "" "" "" "" "" "" "" "" "32.6" "25.4" "32.5" "27.5" "30.3" "28.6" "22.9" "23.8" "43.1" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8080322362920288108" "False" "High" "IsMasterProtein" "Q7Z7F0" "KH homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KHDC4 PE=1 SV=1" "0.000" "False" "9.619" "6" "3" "3" "3" "614" "64.8" "8.73" "9.95" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "" "22889" "ENSG00000132680" "KHDC4" "hsa:22889; O94981; Q7L7Q2; Q7Z7E9; Q7Z7F0; Q8TBQ0" "" "" "0" "0" "1.015" "0.904" "1.162" "0.978" "0.938" "1.006" "1.006" "1.006" "0.876" "197.1" "200.1" "178.1" "228.9" "192.8" "184.9" "198.2" "198.3" "198.3" "172.7" "" "" "" "" "" "" "" "" "" "" "158.3" "144.4" "141.4" "153.4" "133.3" "138.7" "138.7" "144.8" "198.3" "140.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-363787563517568256" "False" "High" "IsMasterProtein" "Q9H165" "B-cell lymphoma/leukemia 11A OS=Homo sapiens OX=9606 GN=BCL11A PE=1 SV=2" "0.000" "False" "9.595" "4" "3" "4" "2" "835" "91.1" "6.61" "10.99" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "53335" "ENSG00000119866" "BCL11A" "D6W5D7; hsa:53335; Q66LN6; Q86W14; Q8WU92; Q96JL6; Q9H163; Q9H164; Q9H165; Q9H3G9; Q9NWA7" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "Prion disease pathway" "3" "1" "0.886" "1.018" "0.921" "0.853" "1.020" "0.977" "1.049" "1.069" "0.921" "236.6" "209.7" "241.0" "217.9" "201.8" "241.5" "231.3" "248.3" "252.8" "217.8" "" "" "" "" "" "" "" "" "" "" "190.0" "151.3" "191.4" "146.0" "139.6" "181.2" "161.9" "181.3" "252.8" "177.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7560312729267318795" "False" "High" "IsMasterProtein" "Q5HYI8" "Rab-like protein 3 OS=Homo sapiens OX=9606 GN=RABL3 PE=1 SV=1" "0.000" "False" "9.581" "8" "2" "2" "2" "236" "26.4" "7.11" "6.96" "2" "transport;other biological processes" "other cell component" "other molecular function" "Pf08477" "285282" "ENSG00000144840" "RABL3" "hsa:285282; Q5HYI8; Q8WUD3" "" "" "0" "0" "1.035" "1.055" "1.050" "1.049" "1.054" "0.904" "0.941" "0.969" "1.001" "499.2" "516.6" "526.8" "524.2" "523.9" "526.1" "451.5" "469.6" "483.9" "499.9" "" "" "" "" "" "" "" "" "" "" "401.0" "372.8" "418.4" "351.2" "362.3" "394.7" "316.1" "342.9" "483.9" "406.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "262985657933925195" "False" "High" "IsMasterProtein" "Q969H6" "Ribonuclease P/MRP protein subunit POP5 OS=Homo sapiens OX=9606 GN=POP5 PE=1 SV=1" "0.000" "False" "9.576" "17" "2" "3" "2" "163" "18.8" "7.27" "10.60" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "51367" "ENSG00000167272" "POP5" "A6NL80; hsa:51367; Q53FS5; Q969H6; Q9Y2Q6" "tRNA processing in the nucleus" "" "1" "0" "0.910" "0.782" "0.913" "0.957" "0.949" "0.828" "0.794" "0.880" "0.880" "168.8" "153.6" "132.0" "154.2" "161.6" "160.3" "139.9" "134.0" "148.5" "148.6" "" "" "" "" "" "" "" "" "" "" "135.6" "110.8" "104.8" "103.3" "111.8" "120.2" "97.9" "97.9" "148.5" "120.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1842086300853461210" "False" "High" "IsMasterProtein" "Q9ULL1" "Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens OX=9606 GN=PLEKHG1 PE=1 SV=2" "0.000" "False" "9.575" "2" "2" "3" "2" "1385" "155.3" "6.24" "9.25" "2" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621" "57480" "ENSG00000120278" "PLEKHG1" "hsa:57480; Q5T1F2; Q9ULL1" "CDC42 GTPase cycle; RAC1 GTPase cycle" "Opioid receptor pathways" "3" "0" "0.990" "0.831" "0.778" "0.967" "0.914" "1.160" "0.925" "1.229" "1.303" "31.1" "30.8" "25.8" "24.2" "30.0" "28.4" "36.1" "28.8" "38.2" "40.5" "" "" "" "" "" "" "" "" "" "" "25.0" "22.2" "20.5" "16.2" "20.8" "21.3" "25.2" "21.0" "38.2" "32.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4559140579210949167" "False" "High" "IsMasterProtein" "P62917" "Large ribosomal subunit protein uL2 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "0.000" "False" "9.551" "10" "3" "3" "3" "257" "28.0" "11.03" "8.73" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Protein hydroxylation; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "1.043" "1.289" "1.341" "1.317" "1.221" "1.486" "1.037" "1.267" "1.201" "83.7" "87.4" "108.0" "112.3" "110.3" "102.2" "124.5" "86.8" "106.1" "100.5" "" "" "" "" "" "" "" "" "" "" "67.3" "63.0" "85.8" "75.3" "76.3" "76.7" "87.2" "63.4" "106.1" "81.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8770420070751581353" "False" "High" "IsMasterProtein" "Q16718" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Homo sapiens OX=9606 GN=NDUFA5 PE=1 SV=3" "0.000" "False" "9.547" "14" "1" "2" "1" "116" "13.5" "5.99" "10.15" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf04716" "4698" "ENSG00000128609" "NDUFA5" "B2RD98; hsa:4698; Q16718; Q5H9R2; Q6IRX7" "RHOG GTPase cycle; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "1.126" "1.287" "1.441" "1.225" "1.337" "1.139" "1.482" "1.469" "1.457" "57.9" "65.3" "74.6" "83.5" "71.0" "77.5" "66.0" "85.9" "85.1" "84.4" "" "" "" "" "" "" "" "" "" "" "46.5" "47.1" "59.2" "55.9" "49.1" "58.1" "46.2" "62.7" "85.1" "68.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5412542927183305238" "False" "High" "IsMasterProtein" "P17535" "Transcription factor JunD OS=Homo sapiens OX=9606 GN=JUND PE=1 SV=3" "0.000" "False" "9.542" "4" "1" "1" "1" "347" "35.2" "7.37" "5.77" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3727" "ENSG00000130522" "JUND" "hsa:3727; P17535; Q53EK9" "NGF-stimulated transcription; Estrogen-dependent gene expression" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; Angiotensin II receptor type 1 pathway; Hypertrophy model; 10q11.21q11.23 copy number variation syndrome; Osteoarthritic chondrocyte hypertrophy" "14" "0" "1.126" "1.105" "1.296" "1.193" "1.092" "1.306" "1.361" "1.227" "1.239" "134.0" "150.9" "148.1" "173.7" "159.9" "146.3" "175.0" "182.4" "164.5" "166.1" "" "" "" "" "" "" "" "" "" "" "107.6" "108.9" "117.7" "116.4" "110.6" "109.8" "122.5" "133.2" "164.5" "135.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8560465734379748063" "False" "High" "IsMasterProtein" "Q9NP77" "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1" "0.000" "False" "9.530" "22" "4" "5" "4" "194" "22.6" "5.33" "11.53" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04722" "29101" "ENSG00000160075" "SSU72" "hsa:29101; Q9BZS6; Q9H933; Q9NP77" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "0.918" "1.045" "1.044" "1.008" "1.199" "0.933" "0.955" "0.942" "1.125" "128.1" "117.5" "133.8" "133.7" "129.1" "153.5" "119.4" "122.3" "120.6" "144.0" "" "" "" "" "" "" "" "" "" "" "102.9" "84.8" "106.3" "89.6" "89.3" "115.2" "83.6" "89.3" "120.6" "117.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7529838149184307642" "False" "High" "IsMasterProtein" "P04066" "Tissue alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA1 PE=1 SV=4" "0.000" "False" "9.521" "4" "2" "2" "2" "466" "53.7" "6.84" "7.25" "2" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01120, Pf16757" "2517" "ENSG00000179163" "FUCA1" "B2RBG3; hsa:2517; P04066; Q14334; Q14335; Q3LID0; Q8NAC2" "Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway" "p53 transcriptional gene network" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986646952840969808" "False" "High" "IsMasterProtein" "Q9BUE6" "Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA1 PE=1 SV=1" "0.000" "False" "9.517" "19" "2" "3" "2" "129" "14.2" "9.07" "6.78" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01521" "81689" "ENSG00000135070" "ISCA1" "B3KP34; B4DJI5; hsa:81689; Q8ND75; Q9BUE6; Q9BZR2" "Mitochondrial iron-sulfur cluster biogenesis" "" "1" "0" "0.955" "0.870" "1.150" "1.020" "1.077" "1.100" "0.986" "1.127" "1.225" "72.4" "69.1" "63.0" "83.2" "73.8" "78.0" "79.6" "71.3" "81.5" "88.7" "" "" "" "" "" "" "" "" "" "" "58.1" "49.8" "50.0" "55.8" "51.0" "58.5" "55.7" "52.1" "81.5" "72.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265591638708801395" "False" "High" "IsMasterProtein" "P62699" "Protein yippee-like 5 OS=Homo sapiens OX=9606 GN=YPEL5 PE=1 SV=1" "0.000" "False" "9.515" "20" "2" "3" "2" "121" "13.8" "7.31" "8.92" "2" "cell cycle OR cell proliferation" "non-structural extracellular;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03226" "51646" "ENSG00000119801" "YPEL5" "D6W568; hsa:51646; P62699; Q65Z97; Q8R174; Q9D6M1; Q9UMX7; Q9Y3C9" "Neutrophil degranulation" "Ciliary landscape" "2" "0" "0.836" "0.902" "0.959" "0.991" "0.891" "0.903" "1.046" "1.050" "0.972" "177.2" "148.2" "159.9" "169.9" "175.6" "157.9" "160.1" "185.4" "186.1" "172.2" "" "" "" "" "" "" "" "" "" "" "142.3" "106.9" "127.0" "113.9" "121.4" "118.5" "112.1" "135.4" "186.1" "140.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5793722554403523201" "False" "High" "IsMasterProtein" "Q14764" "Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4" "0.000" "False" "9.501" "4" "4" "4" "4" "893" "99.3" "5.48" "12.26" "4" "transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01505, Pf11978, Pf17794, Pf17795, Pf17796" "9961" "ENSG00000013364" "MVP" "hsa:9961; Q14764; Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1" "Neutrophil degranulation" "16p11.2 proximal deletion syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8360492989059699249" "False" "High" "IsMasterProtein" "Q9NRM2" "Zinc finger protein 277 OS=Homo sapiens OX=9606 GN=ZNF277 PE=1 SV=2" "0.000" "False" "9.497" "7" "4" "4" "3" "450" "52.8" "5.34" "10.22" "4" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12756" "11179" "ENSG00000198839" "ZNF277" "hsa:11179; Q75MZ2; Q75MZ3; Q8WY14; Q9NRM2" "" "" "0" "0" "0.797" "0.754" "2.488" "1.048" "1.042" "0.962" "1.010" "0.941" "0.999" "155.7" "124.2" "117.4" "387.5" "163.3" "162.2" "149.8" "157.4" "146.6" "155.6" "" "" "" "" "" "" "" "" "" "" "125.1" "89.6" "93.2" "259.6" "112.9" "121.7" "104.9" "114.9" "146.6" "126.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6535746548150786198" "False" "High" "IsMasterProtein" "Q6MZP7" "Protein lin-54 homolog OS=Homo sapiens OX=9606 GN=LIN54 PE=1 SV=3" "0.000" "False" "9.495" "4" "3" "3" "3" "749" "79.4" "9.01" "9.10" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03638" "132660" "ENSG00000189308" "LIN54" "hsa:132660; Q32M68; Q32M69; Q6MZP7; Q6N071; Q76B60" "G1/S-Specific Transcription; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "DYRK1A involvement regarding cell proliferation in brain development" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1768771022967141070" "False" "High" "IsMasterProtein" "Q9Y4H4" "G-protein-signaling modulator 3 OS=Homo sapiens OX=9606 GN=GPSM3 PE=1 SV=1" "0.000" "False" "9.481" "23" "2" "2" "2" "160" "17.9" "4.97" "7.19" "2" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf02188" "63940" "ENSG00000206314; ENSG00000213654; ENSG00000233490; ENSG00000234243; ENSG00000234508; ENSG00000236697; ENSG00000237052" "GPSM3" "A2BFJ3; hsa:63940; Q9Y4H4" "G alpha (i) signalling events" "" "1" "0" "1.048" "0.951" "1.031" "1.024" "1.103" "0.950" "0.927" "0.991" "0.995" "176.6" "185.0" "168.0" "182.0" "180.8" "194.7" "167.6" "163.7" "175.0" "175.7" "" "" "" "" "" "" "" "" "" "" "141.8" "133.5" "133.4" "121.9" "125.0" "146.1" "117.4" "119.5" "175.0" "142.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418944464620685589" "False" "High" "IsMasterProtein" "Q9Y478" "5'-AMP-activated protein kinase subunit beta-1 OS=Homo sapiens OX=9606 GN=PRKAB1 PE=1 SV=4" "0.000" "False" "9.475" "12" "2" "2" "2" "270" "30.4" "6.40" "6.95" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf04739, Pf16561" "5564" "ENSG00000111725" "PRKAB1" "hsa:5564; Q9UBV0; Q9UE20; Q9UEX2; Q9Y478; Q9Y6V8" "TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "25" "0" "0.948" "0.930" "1.053" "1.116" "1.021" "1.057" "1.186" "1.024" "1.035" "208.3" "197.4" "193.6" "219.3" "232.3" "212.6" "220.2" "247.0" "213.2" "215.6" "" "" "" "" "" "" "" "" "" "" "167.3" "142.5" "153.8" "146.9" "160.7" "159.5" "154.2" "180.4" "213.2" "175.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "167158526121610019" "False" "High" "IsMasterProtein" "Q9UPW5" "Cytosolic carboxypeptidase 1 OS=Homo sapiens OX=9606 GN=AGTPBP1 PE=1 SV=3" "0.000" "False" "9.475" "3" "4" "4" "4" "1226" "138.4" "6.15" "10.59" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00246, Pf18027" "23287" "ENSG00000135049" "AGTPBP1" "B4DIT6; B4DRZ8; hsa:23287; Q5VV80; Q63HM7; Q658P5; Q6P9D6; Q9H8U6; Q9H9W8; Q9NVK1; Q9UPW5" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-715832753700784142" "False" "High" "IsMasterProtein" "P22830" "Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2" "0.000" "False" "9.474" "7" "3" "3" "3" "423" "47.8" "8.73" "8.75" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00762" "2235" "ENSG00000066926" "FECH" "A8KA72; hsa:2235; P22830; Q8IXN1; Q8NAN0" "Mitochondrial protein degradation; Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "4" "0" "0.904" "1.007" "1.150" "1.073" "1.032" "0.859" "1.053" "0.916" "1.002" "84.4" "76.2" "84.9" "97.0" "90.5" "87.1" "72.4" "88.9" "77.3" "84.5" "" "" "" "" "" "" "" "" "" "" "67.8" "55.0" "67.5" "65.0" "62.6" "65.3" "50.7" "64.9" "77.3" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8501069546997546105" "False" "High" "IsMasterProtein" "Q8WYQ3" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial OS=Homo sapiens OX=9606 GN=CHCHD10 PE=1 SV=1" "0.000" "False" "9.470" "23" "2" "2" "2" "142" "14.1" "7.84" "6.93" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf06747" "400916" "ENSG00000250479; ENSG00000273607" "CHCHD10" "A8K0J5; hsa:400916; Q8WYQ3" "Mitochondrial protein import" "" "1" "0" "1.047" "1.476" "1.339" "1.392" "1.058" "1.578" "1.058" "0.872" "1.596" "19.7" "20.6" "29.1" "26.4" "27.4" "20.8" "31.1" "20.8" "17.2" "31.5" "" "" "" "" "" "" "" "" "" "" "15.8" "14.9" "23.1" "17.7" "19.0" "15.6" "21.8" "15.2" "17.2" "25.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874212812822634582" "False" "High" "IsMasterProtein" "Q7Z3T8" "Zinc finger FYVE domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ZFYVE16 PE=1 SV=3" "0.000" "False" "9.463" "1" "2" "3" "2" "1539" "168.8" "4.82" "6.34" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11979" "9765" "ENSG00000039319" "ZFYVE16" "hsa:9765; O15023; Q5H9U2; Q7LAU7; Q7Z3T8; Q86T69; Q8N5L3; Q8NEK3" "Signaling by BMP" "TGF-beta signaling pathway" "2" "0" "0.923" "0.822" "1.001" "1.185" "0.798" "1.138" "1.045" "0.899" "1.002" "89.3" "82.4" "73.4" "89.4" "105.8" "71.3" "101.7" "93.3" "80.3" "89.4" "" "" "" "" "" "" "" "" "" "" "71.7" "59.4" "58.3" "59.9" "73.2" "53.5" "71.2" "68.2" "80.3" "72.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8450189262583768708" "False" "High" "IsMasterProtein" "Q96NT0" "Coiled-coil domain-containing protein 115 OS=Homo sapiens OX=9606 GN=CCDC115 PE=1 SV=1" "0.000" "False" "9.455" "8" "1" "2" "1" "180" "19.7" "6.95" "3.98" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf21730" "84317" "ENSG00000136710" "CCDC115" "B4DJ47; hsa:84317; Q96NT0; Q9BR88" "RHOA GTPase cycle" "" "1" "0" "1.167" "0.902" "0.972" "1.096" "0.874" "0.946" "1.349" "1.146" "0.979" "19.5" "22.8" "17.6" "19.0" "21.4" "17.0" "18.5" "26.3" "22.4" "19.1" "" "" "" "" "" "" "" "" "" "" "15.7" "16.4" "14.0" "12.7" "14.8" "12.8" "12.9" "19.2" "22.4" "15.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6535864909566568035" "False" "High" "IsMasterProtein" "O75367" "Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5" "0.000" "False" "9.440" "6" "2" "3" "2" "369" "39.2" "9.83" "9.87" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00125, Pf01661, Pf16211" "9555" "ENSG00000113648" "MACROH2A1" "hsa:9555; O75367; O75377; Q503A8; Q7Z5E3; Q96D41; Q9H8P3; Q9UP96" "" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "2" "0" "1.028" "1.034" "1.120" "1.055" "1.032" "1.133" "1.163" "1.082" "1.073" "338.0" "347.4" "349.4" "378.4" "356.6" "348.9" "383.0" "393.1" "365.7" "362.6" "" "" "" "" "" "" "" "" "" "" "271.4" "250.7" "277.5" "253.5" "246.6" "261.8" "268.2" "287.1" "365.7" "294.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486676491892428044" "False" "High" "IsMasterProtein" "Q92759" "General transcription factor IIH subunit 4 OS=Homo sapiens OX=9606 GN=GTF2H4 PE=1 SV=1" "0.000" "False" "9.436" "6" "2" "2" "2" "462" "52.2" "9.04" "4.58" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03849, Pf18307" "2968" "ENSG00000213780; ENSG00000221974; ENSG00000226384; ENSG00000233149; ENSG00000234370; ENSG00000236895" "GTF2H4" "B4DTJ5; hsa:2968; Q76KU4; Q92759" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase I Transcription Initiation; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "33" "0" "0.982" "0.760" "0.874" "1.185" "1.024" "0.942" "0.883" "0.933" "1.045" "22.0" "21.7" "16.7" "19.3" "26.1" "22.6" "20.8" "19.5" "20.6" "23.0" "" "" "" "" "" "" "" "" "" "" "17.7" "15.6" "13.3" "12.9" "18.1" "16.9" "14.5" "14.2" "20.6" "18.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5517326746891322777" "False" "High" "IsMasterProtein" "Q9H2P0" "Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1" "0.000" "False" "9.433" "3" "4" "4" "4" "1102" "123.5" "7.34" "11.09" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00046, Pf19627" "23394" "ENSG00000101126" "ADNP" "E1P5Y2; hsa:23394; O94881; Q5BKU2; Q9H2P0; Q9UG34" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4110567019566568697" "False" "High" "IsMasterProtein" "Q9P0U4" "CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2" "0.000" "False" "9.431" "5" "3" "3" "3" "656" "75.7" "8.24" "8.75" "3" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf02008, Pf12269" "30827" "ENSG00000154832" "CXXC1" "B2RC03; hsa:30827; Q8N2W4; Q96BC8; Q9P0U4; Q9P2V7" "XBP1(S) activates chaperone genes; Formation of WDR5-containing histone-modifying complexes" "Male infertility" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8775009623055408679" "False" "High" "IsMasterProtein" "Q5BKY9" "Protein FAM133B OS=Homo sapiens OX=9606 GN=FAM133B PE=1 SV=1" "0.000" "False" "9.413" "7" "2" "2" "2" "247" "28.4" "10.02" "8.26" "2" "" "" "" "" "257415" "ENSG00000234545" "FAM133B" "B2R994; hsa:257415; Q05D67; Q5BKY9; Q6P5S6; Q8N0W8" "" "" "0" "0" "0.998" "1.200" "0.988" "1.063" "1.090" "1.130" "1.171" "1.021" "1.024" "365.7" "364.8" "438.6" "361.1" "388.9" "398.7" "413.1" "428.2" "373.4" "374.4" "" "" "" "" "" "" "" "" "" "" "293.7" "263.2" "348.4" "242.0" "268.9" "299.2" "289.2" "312.7" "373.4" "304.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2435225049251902172" "False" "High" "IsMasterProtein" "Q8NEY8" "Periphilin-1 OS=Homo sapiens OX=9606 GN=PPHLN1 PE=1 SV=2" "0.000" "False" "9.411" "5" "2" "3" "2" "458" "52.7" "9.11" "8.72" "2" "cell organization and biogenesis;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf11488" "51535" "ENSG00000134283" "PPHLN1" "E9PAX8; hsa:51535; Q86YT2; Q8IXN3; Q8NEY8; Q8TB09; Q96NB9; Q9NXL4; Q9P0P6; Q9P0R9" "" "" "0" "0" "0.998" "0.936" "0.986" "1.135" "1.121" "0.950" "1.115" "1.138" "1.024" "102.3" "102.1" "95.7" "100.8" "116.1" "114.6" "97.2" "114.0" "116.3" "104.8" "" "" "" "" "" "" "" "" "" "" "82.1" "73.7" "76.0" "67.6" "80.3" "86.0" "68.0" "83.3" "116.3" "85.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4835806217438690237" "False" "High" "IsMasterProtein" "Q9Y2K5" "R3H domain-containing protein 2 OS=Homo sapiens OX=9606 GN=R3HDM2 PE=1 SV=3" "0.000" "False" "9.392" "2" "2" "2" "2" "976" "106.9" "8.85" "6.33" "2" "" "nucleus" "" "Pf01424" "22864" "ENSG00000179912" "R3HDM2" "B7ZL65; hsa:22864; Q2M1T9; Q3ZCT5; Q9Y2K5" "" "" "0" "0" "0.946" "1.551" "1.306" "1.357" "1.443" "1.399" "1.268" "1.388" "1.326" "24.7" "23.4" "38.4" "32.3" "33.6" "35.7" "34.6" "31.4" "34.3" "32.8" "" "" "" "" "" "" "" "" "" "" "19.9" "16.9" "30.5" "21.6" "23.2" "26.8" "24.2" "22.9" "34.3" "26.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7610728054593455927" "False" "High" "IsMasterProtein" "Q86SZ2" "Trafficking protein particle complex subunit 6B OS=Homo sapiens OX=9606 GN=TRAPPC6B PE=1 SV=1" "0.000" "False" "9.386" "20" "3" "3" "3" "158" "18.0" "8.68" "5.93" "3" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "122553" "ENSG00000182400" "TRAPPC6B" "B3KPS2; hsa:122553; Q5JPD6; Q86SZ2; Q86U35; Q86X35" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.003" "1.111" "0.981" "0.987" "0.929" "0.938" "0.962" "0.866" "0.992" "321.2" "322.1" "356.9" "315.1" "317.1" "298.4" "301.3" "308.9" "278.1" "318.6" "" "" "" "" "" "" "" "" "" "" "258.0" "232.4" "283.5" "211.1" "219.3" "223.9" "210.9" "225.6" "278.1" "259.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3817114050720704856" "False" "High" "IsMasterProtein" "Q9H867" "Protein N-lysine methyltransferase METTL21D OS=Homo sapiens OX=9606 GN=VCPKMT PE=1 SV=2" "0.000" "False" "9.376" "12" "2" "2" "2" "229" "25.8" "4.92" "6.86" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf10294" "79609" "ENSG00000100483" "VCPKMT" "B7ZLA3; B7ZLA4; hsa:79609; Q2M2X3; Q86T12; Q9H867" "Protein methylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8554271472140898461" "False" "High" "IsMasterProtein" "Q8N584" "Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=1 SV=2" "0.000" "False" "9.375" "4" "2" "2" "2" "583" "65.8" "6.99" "7.23" "2" "cell organization and biogenesis;developmental processes" "" "" "Pf10300" "125488" "ENSG00000168234" "TTC39C" "B7WP63; hsa:125488; J3QRR1; Q0VAJ2; Q8N284; Q8N584" "" "" "0" "0" "1.133" "0.992" "1.021" "1.122" "1.003" "0.981" "0.974" "0.978" "0.987" "166.1" "188.3" "164.9" "169.6" "186.4" "166.7" "163.0" "161.9" "162.5" "164.0" "" "" "" "" "" "" "" "" "" "" "133.4" "135.9" "131.0" "113.6" "128.9" "125.1" "114.1" "118.2" "162.5" "133.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6020211284576112703" "False" "High" "IsMasterProtein" "Q86UY8" "5'-nucleotidase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NT5DC3 PE=1 SV=1" "0.000" "False" "9.366" "5" "3" "3" "3" "548" "63.4" "8.31" "9.95" "3" "" "cytosol;other cell component" "other molecular function" "Pf05761" "51559" "ENSG00000111696" "NT5DC3" "hsa:51559; Q86UY8; Q9NUM7; Q9P2T2; Q9P2T3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563797319587415269" "False" "High" "IsMasterProtein" "P25208" "Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2" "0.000" "False" "9.361" "10" "2" "3" "2" "207" "22.8" "4.59" "7.68" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "4801" "ENSG00000120837" "NFYB" "A8K7B9; hsa:4801; P25208; Q96IY8" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "" "5" "0" "0.841" "0.937" "0.913" "1.078" "0.920" "0.924" "0.908" "0.896" "0.968" "166.6" "140.2" "156.0" "152.1" "179.6" "153.2" "153.9" "151.2" "149.2" "161.2" "" "" "" "" "" "" "" "" "" "" "133.8" "101.1" "123.9" "101.9" "124.2" "115.0" "107.7" "110.4" "149.2" "131.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8843415988459270294" "False" "High" "IsMasterProtein" "Q7Z2W9" "Large ribosomal subunit protein bL21m OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" "0.000" "False" "9.341" "22" "4" "5" "4" "205" "22.8" "9.89" "11.47" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00829" "219927" "ENSG00000197345" "MRPL21" "A6NKU0; C9JPR2; hsa:219927; Q7Z2W9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8023597143087882212" "False" "High" "IsMasterProtein" "P61925" "cAMP-dependent protein kinase inhibitor alpha OS=Homo sapiens OX=9606 GN=PKIA PE=1 SV=2" "0.000" "False" "9.328" "30" "2" "2" "2" "76" "8.0" "4.54" "7.94" "2" "other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02827" "5569" "ENSG00000171033" "PKIA" "hsa:5569; P04541; P61925; Q6IAV2" "" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6793780653690587443" "False" "High" "IsMasterProtein" "Q99741" "Cell division control protein 6 homolog OS=Homo sapiens OX=9606 GN=CDC6 PE=1 SV=1" "0.000" "False" "9.311" "5" "3" "3" "3" "560" "62.7" "9.58" "8.66" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf09079, Pf13401, Pf17872" "990" "ENSG00000094804" "CDC6" "hsa:990; Q8TB30; Q99741" "Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; G1/S-Specific Transcription; Transcription of E2F targets under negative control by DREAM complex" "Cell cycle; DNA replication" "10" "0" "0.945" "0.950" "0.900" "1.035" "0.987" "1.331" "1.377" "1.346" "1.092" "166.9" "157.7" "158.5" "150.2" "172.8" "164.8" "222.1" "229.9" "224.6" "182.3" "" "" "" "" "" "" "" "" "" "" "134.1" "113.8" "125.9" "100.6" "119.5" "123.6" "155.5" "167.9" "224.6" "148.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1000021269069197599" "False" "High" "IsMasterProtein" "Q9Y5V3" "Melanoma-associated antigen D1 OS=Homo sapiens OX=9606 GN=MAGED1 PE=1 SV=3" "0.000" "False" "9.303" "5" "3" "4" "3" "778" "86.1" "5.83" "9.47" "3" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01454" "9500" "ENSG00000179222" "MAGED1" "hsa:9500; Q5VSH6; Q8IZ84; Q8WY92; Q9H352; Q9HBT4; Q9UF36; Q9Y5V3" "NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand" "5q35 copy number variation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681264021479327249" "False" "High" "IsMasterProtein" "O95396" "Adenylyltransferase and sulfurtransferase MOCS3 OS=Homo sapiens OX=9606 GN=MOCS3 PE=1 SV=1" "0.000" "False" "9.293" "9" "3" "3" "3" "460" "49.6" "6.21" "9.24" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00581, Pf00899" "27304" "ENSG00000124217" "MOCS3" "hsa:27304; O95396" "Molybdenum cofactor biosynthesis" "Metabolic Epileptic Disorders" "2" "0" "1.002" "0.773" "0.934" "0.705" "0.943" "0.786" "0.783" "0.907" "0.885" "85.0" "85.2" "65.7" "79.5" "59.9" "80.2" "66.9" "66.6" "77.1" "75.3" "" "" "" "" "" "" "" "" "" "" "68.3" "61.5" "52.2" "53.2" "41.4" "60.2" "46.8" "48.6" "77.1" "61.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1892813618326208794" "False" "High" "IsMasterProtein" "O95299" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA10 PE=1 SV=1" "0.000" "False" "9.289" "6" "2" "2" "2" "355" "40.7" "8.48" "7.52" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion;other cell component" "transporter activity" "Pf01712" "4705" "ENSG00000130414" "NDUFA10" "hsa:4705; O95299; Q8WXC9" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; 2q37 copy number variation syndrome; Oxidative phosphorylation" "6" "0" "1.092" "1.016" "0.923" "1.062" "1.101" "0.863" "1.023" "1.087" "0.993" "81.5" "89.0" "82.8" "75.2" "86.5" "89.7" "70.3" "83.4" "88.5" "80.9" "" "" "" "" "" "" "" "" "" "" "65.4" "64.2" "65.7" "50.4" "59.8" "67.3" "49.2" "60.9" "88.5" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9003778122824522310" "False" "High" "IsMasterProtein" "Q9BRT3" "Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1" "0.000" "False" "9.280" "16" "2" "2" "2" "115" "12.4" "4.37" "7.32" "2" "other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf10262" "84299" "ENSG00000141741" "MIEN1" "hsa:84299; Q9BRT3" "" "17q12 copy number variation syndrome" "1" "0" "1.112" "0.990" "0.976" "1.044" "1.086" "1.001" "1.012" "1.025" "1.044" "259.9" "289.1" "257.3" "253.7" "271.2" "282.2" "260.1" "263.1" "266.4" "271.3" "" "" "" "" "" "" "" "" "" "" "208.8" "208.6" "204.4" "170.0" "187.6" "211.8" "182.1" "192.2" "266.4" "220.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8022290740510184659" "False" "High" "IsMasterProtein" "P49257" "Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2" "0.000" "False" "9.271" "6" "3" "3" "3" "510" "57.5" "6.77" "9.52" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03388" "3998" "ENSG00000074695" "LMAN1" "hsa:3998; P49257; Q12895; Q8N5I7; Q9UQG1; Q9UQG2; Q9UQG3; Q9UQG4; Q9UQG5; Q9UQG6; Q9UQG7; Q9UQG8; Q9UQG9; Q9UQH0; Q9UQH1; Q9UQH2" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Complement and coagulation cascades" "12" "0" "1.165" "0.949" "1.185" "1.111" "1.125" "1.255" "1.136" "1.173" "1.149" "143.1" "166.7" "135.8" "169.6" "159.0" "160.9" "179.6" "162.5" "167.9" "164.4" "" "" "" "" "" "" "" "" "" "" "114.9" "120.3" "107.8" "113.6" "110.0" "120.8" "125.8" "118.7" "167.9" "133.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2762375354567501212" "False" "High" "IsMasterProtein" "Q9UI14" "Prenylated Rab acceptor protein 1 OS=Homo sapiens OX=9606 GN=RABAC1 PE=1 SV=1" "0.000" "False" "9.268" "8" "1" "1" "1" "185" "20.6" "7.34" "3.75" "1" "" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf03208" "10567" "ENSG00000105404" "RABAC1" "hsa:10567; Q7Z4Y2; Q9UI14; Q9Y3R1" "" "Intracellular trafficking proteins involved in CMT neuropathy" "1" "0" "1.047" "1.099" "1.086" "1.134" "1.135" "1.062" "1.096" "1.108" "1.176" "111.5" "116.8" "122.6" "121.1" "126.4" "126.6" "118.5" "122.3" "123.6" "131.2" "" "" "" "" "" "" "" "" "" "" "89.6" "84.3" "97.4" "81.1" "87.4" "95.0" "83.0" "89.3" "123.6" "106.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101695172236042640" "False" "High" "IsMasterProtein" "P82921" "Small ribosomal subunit protein bS21m OS=Homo sapiens OX=9606 GN=MRPS21 PE=1 SV=3" "0.000" "False" "9.268" "30" "2" "3" "2" "87" "10.7" "9.92" "7.71" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01165" "54460" "ENSG00000266472" "MRPS21" "A0A075B746; hsa:54460; P82921; Q5TB11; Q9BST6" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.985" "1.073" "0.778" "0.973" "0.885" "0.967" "0.931" "0.754" "0.975" "92.8" "91.4" "99.5" "72.2" "90.2" "82.1" "89.8" "86.4" "70.0" "90.5" "" "" "" "" "" "" "" "" "" "" "74.5" "65.9" "79.1" "48.4" "62.4" "61.6" "62.8" "63.1" "70.0" "73.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8251896987743937176" "False" "High" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "0.000" "False" "9.260" "27" "4" "6" "4" "142" "17.0" "6.18" "12.49" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "MHC class II antigen presentation; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "18" "0" "1.022" "0.995" "1.084" "1.021" "1.017" "0.994" "0.949" "1.091" "1.001" "154.6" "158.0" "153.7" "167.6" "157.9" "157.3" "153.7" "146.7" "168.7" "154.7" "" "" "" "" "" "" "" "" "" "" "124.2" "114.0" "122.1" "112.3" "109.2" "118.0" "107.6" "107.2" "168.7" "125.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1066675422461662542" "False" "High" "IsMasterProtein" "Q8WVE0" "EEF1A lysine methyltransferase 1 OS=Homo sapiens OX=9606 GN=EEF1AKMT1 PE=1 SV=1" "0.000" "False" "9.255" "8" "2" "3" "2" "214" "24.5" "4.55" "7.43" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf10237" "221143" "ENSG00000150456" "EEF1AKMT1" "B5G4V1; hsa:221143; Q8WVE0" "Protein methylation" "" "1" "0" "0.875" "0.889" "1.024" "0.975" "0.957" "1.002" "1.003" "0.919" "0.918" "293.8" "257.0" "261.2" "301.0" "286.4" "281.0" "294.4" "294.7" "270.0" "269.7" "" "" "" "" "" "" "" "" "" "" "236.0" "185.4" "207.5" "201.7" "198.1" "210.9" "206.1" "215.2" "270.0" "219.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5902665754527388004" "False" "High" "IsMasterProtein" "Q969R8" "KICSTOR complex protein ITFG2 OS=Homo sapiens OX=9606 GN=ITFG2 PE=1 SV=1" "0.000" "False" "9.246" "5" "2" "3" "2" "447" "49.3" "5.22" "8.34" "2" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf15907" "55846" "ENSG00000111203" "ITFG2" "A8K4Z5; D3DUQ2; hsa:55846; Q6PKU5; Q969R8; Q96SX6" "Amino acids regulate mTORC1" "" "1" "0" "1.051" "0.998" "0.921" "1.182" "1.296" "1.048" "0.836" "1.116" "0.991" "50.2" "52.8" "50.1" "46.2" "59.3" "65.1" "52.6" "42.0" "56.0" "49.8" "" "" "" "" "" "" "" "" "" "" "40.3" "38.1" "39.8" "31.0" "41.0" "48.8" "36.8" "30.7" "56.0" "40.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7420075580370482485" "False" "High" "IsMasterProtein" "P14209" "CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 PE=1 SV=1" "0.000" "False" "9.222" "13" "2" "2" "2" "185" "18.8" "4.75" "5.92" "2" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf12301" "4267" "ENSG00000002586; ENSG00000292348" "CD99" "A6NIW1; hsa:4267; O00518; P14209; Q6ICV7" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall" "" "2" "0" "1.048" "0.819" "0.939" "1.185" "1.239" "1.284" "0.942" "0.985" "1.105" "55.4" "58.0" "45.4" "52.0" "65.6" "68.6" "71.1" "52.2" "54.6" "61.2" "" "" "" "" "" "" "" "" "" "" "44.5" "41.9" "36.0" "34.8" "45.4" "51.5" "49.8" "38.1" "54.6" "49.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6208634135307330971" "False" "High" "IsMasterProtein" "P17480" "Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1" "0.000" "False" "9.214" "4" "3" "3" "3" "764" "89.4" "5.81" "9.37" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011, Pf14887" "7343" "ENSG00000108312" "UBTF" "A8K6R8; hsa:7343; P17480" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening" "Ectoderm differentiation" "6" "0" "1.119" "1.017" "1.101" "1.128" "1.063" "1.393" "1.136" "1.158" "1.029" "74.8" "83.6" "76.1" "82.3" "84.3" "79.5" "104.1" "84.9" "86.6" "77.0" "" "" "" "" "" "" "" "" "" "" "60.0" "60.4" "60.4" "55.2" "58.3" "59.6" "72.9" "62.0" "86.6" "62.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8867340794532680383" "False" "High" "IsMasterProtein" "O94967" "WD repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=WDR47 PE=1 SV=1" "0.000" "False" "9.212" "3" "3" "4" "3" "919" "101.9" "5.94" "13.08" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400, Pf17814" "22911" "ENSG00000085433" "WDR47" "A8MX09; hsa:22911; O94967; Q5TYV7; Q5TYV8; Q5TYV9; Q8IXT7; Q8IYU9" "" "" "0" "0" "0.970" "1.005" "1.130" "1.405" "1.118" "1.361" "1.358" "1.249" "1.430" "156.2" "151.6" "157.0" "176.6" "219.6" "174.6" "212.6" "212.2" "195.1" "223.5" "" "" "" "" "" "" "" "" "" "" "125.5" "109.4" "124.7" "118.3" "151.9" "131.0" "148.9" "155.0" "195.1" "181.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "649692950129023278" "False" "High" "IsMasterProtein" "Q96QF0" "Rab-3A-interacting protein OS=Homo sapiens OX=9606 GN=RAB3IP PE=1 SV=1" "0.000" "False" "9.212" "4" "2" "2" "2" "476" "53.0" "5.97" "7.38" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf06428" "117177" "ENSG00000127328" "RAB3IP" "B7WPJ6; hsa:117177; Q6PCE4; Q96A24; Q96QE6; Q96QE7; Q96QE8; Q96QE9; Q96QF0; Q96QF1; Q9H673" "Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; BBSome-mediated cargo-targeting to cilium; VxPx cargo-targeting to cilium" "Joubert syndrome" "5" "0" "1.038" "0.919" "0.971" "1.083" "1.075" "1.057" "1.129" "1.123" "1.108" "299.0" "310.5" "274.9" "290.4" "323.7" "321.3" "316.0" "337.5" "335.6" "331.4" "" "" "" "" "" "" "" "" "" "" "240.2" "224.0" "218.3" "194.6" "223.9" "241.1" "221.3" "246.4" "335.6" "269.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867390860608568122" "False" "High" "IsMasterProtein" "Q9BRJ2" "Large ribosomal subunit protein mL45 OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2" "0.000" "False" "9.150" "6" "2" "3" "2" "306" "35.3" "9.03" "6.29" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf04280" "" "ENSG00000277936" "MRPL45" "A1L436; Q6ZMJ5; Q9BRJ2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.081" "1.083" "0.868" "1.066" "1.130" "0.984" "0.942" "0.876" "1.039" "110.6" "119.5" "119.8" "96.0" "117.9" "125.0" "108.8" "104.2" "96.8" "114.9" "" "" "" "" "" "" "" "" "" "" "88.8" "86.2" "95.1" "64.3" "81.5" "93.8" "76.2" "76.1" "96.8" "93.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-268606970100877469" "False" "High" "IsMasterProtein" "Q15834" "Coiled-coil domain-containing protein 85B OS=Homo sapiens OX=9606 GN=CCDC85B PE=1 SV=2" "0.000" "False" "9.149" "16" "2" "2" "1" "202" "22.1" "5.08" "5.94" "2" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10226" "11007" "ENSG00000175602" "CCDC85B" "B2R598; hsa:11007; Q15834; Q96HA0" "" "" "0" "0" "1.100" "1.240" "0.889" "0.943" "1.374" "1.387" "1.155" "1.144" "1.071" "26.2" "28.8" "32.5" "23.3" "24.7" "36.0" "36.3" "30.3" "30.0" "28.0" "" "" "" "" "" "" "" "" "" "" "21.0" "20.8" "25.8" "15.6" "17.1" "27.0" "25.4" "22.1" "30.0" "22.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2807670351825780389" "False" "High" "IsMasterProtein" "P0DI82" "Trafficking protein particle complex subunit 2B OS=Homo sapiens OX=9606 GN=TRAPPC2B PE=1 SV=1" "0.000" "False" "9.148" "16" "2" "4" "2" "140" "16.4" "6.52" "12.21" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04628" "6399" "ENSG00000256060" "TRAPPC2B" "A6NEG0; hsa:6399; O14582; P0DI82; Q9HD16" "" "" "0" "0" "0.932" "1.034" "1.001" "0.890" "0.855" "0.876" "1.055" "0.887" "0.942" "87.7" "81.7" "90.7" "87.8" "78.1" "75.0" "76.9" "92.6" "77.8" "82.6" "" "" "" "" "" "" "" "" "" "" "70.4" "59.0" "72.0" "58.8" "54.0" "56.3" "53.8" "67.6" "77.8" "67.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1077886033734645757" "False" "High" "IsMasterProtein" "Q5SQI0" "Alpha-tubulin N-acetyltransferase 1 OS=Homo sapiens OX=9606 GN=ATAT1 PE=1 SV=1" "0.000" "False" "9.146" "5" "2" "2" "2" "421" "46.8" "9.95" "6.77" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf05301" "79969" "ENSG00000137343; ENSG00000206488; ENSG00000223752; ENSG00000229061; ENSG00000231257; ENSG00000234549; ENSG00000235658" "ATAT1" "A2AB28; hsa:79969; Q3LIB0; Q5JP39; Q5JP40; Q5JP42; Q5SQI0; Q5SQI1; Q5SU03; Q86X42; Q8NDK9; Q9BRS1; Q9H8X5" "Cilium Assembly" "" "1" "0" "1.298" "1.185" "1.590" "1.343" "1.229" "1.366" "1.410" "1.485" "1.449" "101.7" "132.1" "120.6" "161.8" "136.6" "125.0" "139.0" "143.5" "151.1" "147.4" "" "" "" "" "" "" "" "" "" "" "81.7" "95.3" "95.8" "108.4" "94.5" "93.8" "97.3" "104.8" "151.1" "119.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830311805247258078" "False" "High" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "0.000" "False" "9.142" "11" "3" "3" "3" "245" "26.4" "6.52" "6.66" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.023" "1.072" "1.051" "1.053" "1.191" "1.260" "1.033" "1.028" "1.108" "145.9" "149.3" "156.4" "153.3" "153.7" "173.7" "183.9" "150.7" "150.1" "161.6" "" "" "" "" "" "" "" "" "" "" "117.2" "107.7" "124.2" "102.7" "106.3" "130.4" "128.8" "110.1" "150.1" "131.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2309309010695254198" "False" "High" "IsMasterProtein" "Q7Z6J8" "E3 ubiquitin-protein ligase E3D OS=Homo sapiens OX=9606 GN=UBE3D PE=1 SV=2" "0.000" "False" "9.134" "6" "2" "2" "2" "389" "43.6" "8.13" "8.40" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09814" "90025" "ENSG00000118420" "UBE3D" "B4DP63; hsa:90025; Q5T4W2; Q6IPR4; Q75UG0; Q7Z6J8; Q9NT42" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.109" "0.886" "1.168" "1.134" "1.066" "1.042" "1.238" "1.144" "1.135" "51.2" "56.8" "45.4" "59.9" "58.1" "54.6" "53.4" "63.5" "58.6" "58.1" "" "" "" "" "" "" "" "" "" "" "41.2" "41.0" "36.0" "40.1" "40.2" "41.0" "37.4" "46.3" "58.6" "47.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5710815529521285644" "False" "High" "IsMasterProtein" "Q9BQ70" "Ribosome quality control complex subunit TCF25 OS=Homo sapiens OX=9606 GN=TCF25 PE=1 SV=1" "0.000" "False" "9.133" "7" "4" "4" "4" "676" "76.6" "6.35" "10.70" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04910" "22980" "ENSG00000141002" "TCF25" "hsa:22980; Q2MK75; Q9BQ70; Q9UPV3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3862869163996360692" "False" "High" "IsMasterProtein" "Q7LBR1" "Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1" "0.000" "False" "9.131" "12" "3" "3" "3" "199" "22.1" "8.10" "8.21" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "57132" "ENSG00000255112" "CHMP1B" "hsa:57132; Q7LBR1; Q96E89; Q9HD41" "" "" "0" "0" "1.040" "0.885" "1.067" "0.962" "0.853" "0.964" "0.910" "0.797" "0.952" "265.7" "276.4" "235.3" "283.5" "255.6" "226.6" "256.2" "241.7" "211.7" "252.9" "" "" "" "" "" "" "" "" "" "" "213.4" "199.4" "186.9" "190.0" "176.8" "170.0" "179.4" "176.5" "211.7" "205.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3273487821867758056" "False" "High" "IsMasterProtein" "Q96DV4" "Large ribosomal subunit protein mL38 OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" "0.000" "False" "9.131" "7" "3" "3" "3" "380" "44.6" "7.53" "8.65" "3" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf01161" "64978" "ENSG00000204316" "MRPL38" "B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.304" "1.193" "1.328" "1.130" "0.929" "1.177" "1.154" "1.080" "1.011" "40.1" "52.3" "47.8" "53.2" "45.3" "37.2" "47.2" "46.3" "43.3" "40.5" "" "" "" "" "" "" "" "" "" "" "32.2" "37.7" "38.0" "35.7" "31.3" "27.9" "33.0" "33.8" "43.3" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2186364449985292911" "False" "High" "IsMasterProtein" "P63172" "Dynein light chain Tctex-type 1 OS=Homo sapiens OX=9606 GN=DYNLT1 PE=1 SV=1" "0.000" "False" "9.129" "14" "1" "1" "1" "113" "12.4" "5.08" "5.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03645" "6993" "ENSG00000146425" "DYNLT1" "hsa:6993; P63172; Q15763; Q5VTU4" "Neutrophil degranulation" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "5" "0" "1.019" "1.011" "0.917" "1.178" "0.997" "1.082" "1.023" "1.193" "0.954" "142.7" "145.5" "144.3" "130.9" "168.1" "142.3" "154.4" "146.0" "170.3" "136.2" "" "" "" "" "" "" "" "" "" "" "114.7" "105.0" "114.7" "87.7" "116.3" "106.8" "108.1" "106.6" "170.3" "110.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5402441647647125323" "False" "High" "IsMasterProtein" "O75880" "Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1" "0.000" "False" "9.124" "11" "4" "5" "4" "301" "33.8" "8.88" "16.16" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "6341" "ENSG00000133028" "SCO1" "B2RDM0; hsa:6341; O75880" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis" "5" "0" "0.919" "0.859" "0.916" "1.127" "1.074" "0.891" "0.987" "0.977" "1.071" "255.6" "234.9" "219.6" "234.1" "287.9" "274.4" "227.9" "252.3" "249.7" "273.8" "" "" "" "" "" "" "" "" "" "" "205.3" "169.5" "174.4" "156.9" "199.1" "205.9" "159.5" "184.3" "249.7" "222.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064398730154585057" "False" "High" "IsMasterProtein" "Q15061" "WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3" "0.000" "False" "9.119" "5" "4" "4" "4" "677" "74.8" "5.57" "8.11" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04003" "23160" "ENSG00000163811" "WDR43" "hsa:23160; Q15061; Q15395; Q92577" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.937" "1.109" "1.144" "1.083" "1.017" "1.031" "0.954" "0.981" "0.943" "227.0" "212.6" "251.7" "259.7" "245.8" "230.9" "234.2" "216.6" "222.7" "214.1" "" "" "" "" "" "" "" "" "" "" "182.3" "153.4" "199.9" "174.0" "170.0" "173.3" "163.9" "158.1" "222.7" "174.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-512652790618625432" "False" "High" "IsMasterProtein" "P40259" "B-cell antigen receptor complex-associated protein beta chain OS=Homo sapiens OX=9606 GN=CD79B PE=1 SV=1" "0.000" "False" "9.113" "12" "1" "1" "1" "229" "26.0" "5.92" "4.34" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf07686" "974" "ENSG00000007312" "CD79B" "hsa:974; P40259; Q53FS2; Q9BU06" "CD22 mediated BCR regulation; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385362476021457625" "False" "High" "IsMasterProtein" "B3KNS4" "Endogenous retrovirus group K3 member 1 OS=Homo sapiens OX=9606 GN=ERVK3-1 PE=1 SV=1" "0.000" "False" "9.113" "27" "3" "3" "3" "109" "11.6" "7.78" "8.27" "3" "" "" "" "Pf15695" "" "ENSG00000142396" "ERVK3-1" "B3KNS4" "" "" "0" "0" "1.301" "1.406" "1.421" "1.333" "1.229" "1.281" "1.565" "0.998" "1.278" "195.5" "254.4" "274.8" "277.8" "260.6" "240.3" "250.5" "305.9" "195.1" "249.8" "" "" "" "" "" "" "" "" "" "" "157.0" "183.6" "218.3" "186.1" "180.2" "180.3" "175.4" "223.4" "195.1" "203.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224070834007844842" "False" "High" "IsMasterProtein" "Q9BW91" "ADP-ribose pyrophosphatase, mitochondrial OS=Homo sapiens OX=9606 GN=NUDT9 PE=1 SV=1" "0.000" "False" "9.102" "12" "4" "5" "4" "350" "39.1" "8.22" "13.95" "4" "other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293" "53343" "ENSG00000170502" "NUDT9" "hsa:53343; Q8NBN1; Q8NCB9; Q8NG25; Q9BW91" "" "" "0" "0" "0.979" "1.039" "0.959" "1.018" "1.090" "0.981" "1.035" "1.054" "1.117" "408.2" "399.8" "424.1" "391.4" "415.6" "445.2" "400.4" "422.4" "430.3" "456.0" "" "" "" "" "" "" "" "" "" "" "327.9" "288.5" "336.9" "262.2" "287.4" "334.0" "280.3" "308.5" "430.3" "370.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2431037713967118528" "False" "High" "IsMasterProtein" "Q9NW13" "RNA-binding protein 28 OS=Homo sapiens OX=9606 GN=RBM28 PE=1 SV=3" "0.000" "False" "9.099" "2" "1" "1" "1" "759" "85.7" "9.22" "4.18" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "55131" "ENSG00000106344" "RBM28" "A4D100; B4DU52; E9PDD9; hsa:55131; Q53H65; Q96CV3; Q9NW13" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.156" "1.218" "1.071" "1.004" "0.989" "1.046" "1.057" "1.048" "1.096" "66.0" "76.3" "80.4" "70.7" "66.3" "65.3" "69.1" "69.8" "69.2" "72.3" "" "" "" "" "" "" "" "" "" "" "53.0" "55.1" "63.9" "47.4" "45.8" "49.0" "48.4" "51.0" "69.2" "58.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7240944493038279722" "False" "High" "IsMasterProtein" "Q9Y676" "Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1" "0.000" "False" "9.096" "8" "2" "3" "2" "258" "29.4" "9.38" "10.42" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01084" "28973" "ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813" "MRPS18B" "A6NDQ0; hsa:28973; Q659G4; Q9BS27; Q9Y676" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.171" "0.991" "1.042" "1.074" "1.038" "0.911" "1.116" "0.913" "1.016" "248.0" "290.5" "245.8" "258.3" "266.2" "257.4" "225.8" "276.6" "226.4" "251.9" "" "" "" "" "" "" "" "" "" "" "199.2" "209.6" "195.2" "173.1" "184.1" "193.1" "158.1" "202.0" "226.4" "204.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084351700158867792" "False" "High" "IsMasterProtein" "Q9HD33" "Large ribosomal subunit protein uL29m OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" "0.000" "False" "9.081" "12" "3" "5" "3" "250" "29.4" "10.37" "9.76" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf06984" "57129" "ENSG00000136522" "MRPL47" "hsa:57129; Q6XRG1; Q8N5D1; Q9HD33" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.141" "1.156" "1.497" "1.530" "1.285" "1.306" "1.344" "1.482" "1.136" "42.1" "48.0" "48.6" "63.0" "64.4" "54.1" "54.9" "56.5" "62.4" "47.8" "" "" "" "" "" "" "" "" "" "" "33.8" "34.6" "38.6" "42.2" "44.5" "40.6" "38.5" "41.3" "62.4" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4790562829176069588" "False" "High" "IsMasterProtein" "Q9BV19" "Uncharacterized protein C1orf50 OS=Homo sapiens OX=9606 GN=C1orf50 PE=1 SV=2" "0.000" "False" "9.080" "12" "2" "5" "2" "199" "21.9" "5.88" "15.21" "2" "" "" "other molecular function" "Pf10504" "79078" "ENSG00000164008" "C1orf50" "Q9BV19" "" "" "0" "0" "0.818" "0.882" "0.800" "0.769" "1.076" "0.970" "0.877" "0.807" "1.058" "95.7" "78.3" "84.4" "76.5" "73.6" "103.0" "92.8" "84.0" "77.2" "101.2" "" "" "" "" "" "" "" "" "" "" "76.9" "56.5" "67.1" "51.3" "50.9" "77.3" "65.0" "61.3" "77.2" "82.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3258131120717726760" "False" "High" "IsMasterProtein" "Q96EU6" "Ribosomal RNA processing protein 36 homolog OS=Homo sapiens OX=9606 GN=RRP36 PE=1 SV=1" "0.000" "False" "9.074" "6" "1" "1" "1" "259" "29.8" "10.17" "5.94" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06102" "88745" "ENSG00000124541" "RRP36" "hsa:88745; Q96EU6; Q9BRF6; Q9P0C8" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.100" "1.066" "1.141" "1.268" "1.123" "1.361" "1.235" "1.185" "1.187" "96.2" "105.9" "102.5" "109.8" "122.0" "108.1" "131.0" "118.9" "114.0" "114.2" "" "" "" "" "" "" "" "" "" "" "77.3" "76.4" "81.5" "73.6" "84.4" "81.1" "91.7" "86.8" "114.0" "92.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224423870794083930" "False" "High" "IsMasterProtein" "P49356" "Protein farnesyltransferase subunit beta OS=Homo sapiens OX=9606 GN=FNTB PE=1 SV=1" "0.000" "False" "9.074" "6" "3" "5" "3" "437" "48.7" "5.82" "17.46" "3" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00432" "100529261; 2342" "ENSG00000257365" "FNTB" "B2RDX6; B4E1A0; hsa:100529261; hsa:2342; P49356" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing" "" "3" "0" "0.961" "1.046" "0.905" "0.997" "1.028" "0.874" "0.974" "0.990" "1.012" "740.4" "711.7" "774.6" "669.8" "738.2" "761.1" "647.3" "721.2" "732.7" "749.4" "" "" "" "" "" "" "" "" "" "" "594.7" "513.6" "615.3" "448.7" "510.5" "571.0" "453.2" "526.7" "732.7" "609.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343955122227256194" "False" "High" "IsMasterProtein" "Q01831" "DNA repair protein complementing XP-C cells OS=Homo sapiens OX=9606 GN=XPC PE=1 SV=4" "0.000" "False" "9.062" "3" "3" "3" "3" "940" "105.9" "8.90" "11.05" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03835, Pf10403, Pf10404, Pf10405" "7508" "ENSG00000154767" "XPC" "B4DIP3; E9PB96; E9PH69; hsa:7508; Q01831; Q53GT7; Q96AX0" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "1.023" "1.093" "1.182" "1.052" "1.160" "1.141" "1.185" "1.145" "1.165" "232.7" "238.1" "254.3" "275.1" "244.8" "270.0" "265.6" "275.7" "266.4" "271.1" "" "" "" "" "" "" "" "" "" "" "186.9" "171.8" "202.0" "184.3" "169.3" "202.6" "185.9" "201.4" "266.4" "220.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801504579459921117" "False" "High" "IsMasterProtein" "Q8IXQ3" "Uncharacterized protein C9orf40 OS=Homo sapiens OX=9606 GN=C9orf40 PE=1 SV=1" "0.000" "False" "9.055" "18" "3" "3" "3" "194" "21.1" "5.01" "6.85" "3" "" "" "" "Pf15017" "55071" "ENSG00000135045" "C9orf40" "hsa:55071; Q8IXQ3; Q9NWD3" "" "" "0" "0" "0.988" "0.999" "1.185" "1.184" "1.081" "1.201" "0.995" "1.067" "1.006" "131.9" "130.4" "131.8" "156.3" "156.2" "142.6" "158.4" "131.2" "140.8" "132.8" "" "" "" "" "" "" "" "" "" "" "106.0" "94.1" "104.7" "104.7" "108.0" "107.0" "110.9" "95.8" "140.8" "108.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2600353075121762102" "False" "High" "IsMasterProtein" "A4D161" "Protein FAM221A OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1" "0.000" "False" "9.046" "6" "1" "1" "1" "298" "33.1" "6.74" "4.63" "1" "" "" "" "Pf14753" "340277" "ENSG00000188732" "FAM221A" "A4D161; hsa:340277; Q05CG4; Q4G0Q7; Q6P519" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523601130490084284" "False" "High" "IsMasterProtein" "Q9BX63" "Fanconi anemia group J protein OS=Homo sapiens OX=9606 GN=BRIP1 PE=1 SV=2" "0.000" "False" "9.043" "2" "3" "3" "3" "1249" "140.8" "6.92" "10.08" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf13307" "83990" "ENSG00000136492" "BRIP1" "A0A024QZ45; hsa:83990; Q3MJE2; Q8NCI5; Q9BX63" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Cytosolic iron-sulfur cluster assembly" "DNA repair pathways, full network" "16" "0" "1.071" "1.090" "1.113" "1.145" "1.111" "1.181" "1.248" "1.263" "1.121" "217.9" "233.3" "237.6" "242.6" "249.5" "242.0" "257.4" "272.0" "275.2" "244.3" "" "" "" "" "" "" "" "" "" "" "175.0" "168.4" "188.7" "162.5" "172.5" "181.6" "180.2" "198.7" "275.2" "198.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5515893546974733261" "False" "High" "IsMasterProtein" "E9PRG8" "Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11orf98 PE=1 SV=2" "0.000" "False" "9.043" "11" "1" "1" "1" "123" "14.2" "11.53" "4.56" "1" "" "" "" "Pf17719" "102288414" "ENSG00000278615" "C11orf98" "A0A0B4J220; E9PRG8; hsa:102288414" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "43561169089107894" "False" "High" "IsMasterProtein" "Q5VWG9" "Transcription initiation factor TFIID subunit 3 OS=Homo sapiens OX=9606 GN=TAF3 PE=1 SV=1" "0.000" "False" "9.032" "3" "2" "2" "2" "929" "103.5" "9.06" "6.97" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf00628, Pf07524" "83860" "ENSG00000165632" "TAF3" "hsa:83860; Q05DA0; Q5VWG9; Q6GMS5; Q6P6B5; Q86VY6; Q9BQS9; Q9UFI8" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "9" "0" "0.995" "0.870" "0.833" "1.053" "0.970" "1.133" "0.930" "1.006" "1.035" "40.4" "40.2" "35.2" "33.7" "42.6" "39.2" "45.8" "37.6" "40.7" "41.8" "" "" "" "" "" "" "" "" "" "" "32.5" "29.0" "27.9" "22.5" "29.4" "29.4" "32.1" "27.5" "40.7" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5616367941086101468" "False" "High" "IsMasterProtein" "Q9NRW7" "Vacuolar protein sorting-associated protein 45 OS=Homo sapiens OX=9606 GN=VPS45 PE=1 SV=1" "0.000" "False" "9.011" "5" "2" "2" "2" "570" "65.0" "8.24" "7.10" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf00995" "11311" "ENSG00000136631" "VPS45" "D3DUZ9; F5H8K1; hsa:11311; Q15715; Q53FR8; Q5T4P6; Q9NRW7; Q9Y4Z6" "Factors involved in megakaryocyte development and platelet production; Intra-Golgi traffic; SARS-CoV-2 modulates autophagy" "" "3" "0" "1.357" "0.955" "1.181" "1.236" "0.967" "1.127" "0.909" "1.122" "0.939" "40.2" "54.6" "38.4" "47.5" "49.7" "38.9" "45.3" "36.6" "45.1" "37.8" "" "" "" "" "" "" "" "" "" "" "32.3" "39.4" "30.5" "31.8" "34.4" "29.2" "31.7" "26.7" "45.1" "30.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8083299006508235950" "False" "High" "IsMasterProtein" "O94761" "ATP-dependent DNA helicase Q4 OS=Homo sapiens OX=9606 GN=RECQL4 PE=1 SV=2" "0.000" "False" "9.009" "2" "2" "2" "2" "1208" "133.0" "8.09" "6.75" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf11719" "9401" "ENSG00000160957" "RECQL4" "A0A087WZ30; hsa:9401; O94761; Q3Y424; Q96DW2; Q96F55" "" "Primary ovarian insufficiency" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7619751379045493323" "False" "High" "IsMasterProtein" "P04062" "Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA1 PE=1 SV=3" "0.000" "False" "8.999" "4" "2" "2" "2" "536" "59.7" "7.61" "6.12" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf02055, Pf17189" "2629" "ENSG00000177628" "GBA1" "A8K796; B7Z5G2; B7Z6S1; hsa:2629; J3KQG4; J3KQK9; P04062; Q16545; Q4VX22; Q6I9R6; Q9UMJ8" "Association of TriC/CCT with target proteins during biosynthesis; Glycosphingolipid catabolism" "Sphingolipid pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7796576881168078978" "False" "High" "IsMasterProtein" "Q9P2R6" "Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens OX=9606 GN=RERE PE=1 SV=2" "0.000" "False" "8.995" "1" "2" "2" "2" "1566" "172.3" "7.69" "7.23" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf01426, Pf01448, Pf03154" "473" "ENSG00000142599" "RERE" "hsa:473; O43393; O75046; O75359; Q5VXL9; Q6P6B9; Q9P2R6; Q9Y2W4" "" "" "0" "0" "0.957" "0.914" "0.908" "0.828" "0.926" "0.868" "0.889" "1.000" "0.919" "115.2" "110.3" "105.3" "104.7" "95.4" "106.7" "100.1" "102.4" "115.2" "106.0" "" "" "" "" "" "" "" "" "" "" "92.6" "79.6" "83.6" "70.1" "66.0" "80.1" "70.1" "74.8" "115.2" "86.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340038493485661404" "False" "High" "IsMasterProtein" "O75665" "Centriole and centriolar satellite protein OFD1 OS=Homo sapiens OX=9606 GN=OFD1 PE=1 SV=1" "0.000" "False" "8.995" "3" "3" "3" "3" "1012" "116.6" "6.10" "8.04" "3" "cell organization and biogenesis;transport;developmental processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf16045" "8481" "ENSG00000046651" "OFD1" "B9ZVU5; hsa:8481; O75665; O75666; Q4VAK4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies" "11" "0" "1.200" "1.105" "1.204" "1.055" "1.159" "1.171" "1.141" "1.102" "1.190" "74.4" "89.2" "82.2" "89.5" "78.4" "86.1" "87.0" "84.9" "82.0" "88.5" "" "" "" "" "" "" "" "" "" "" "59.7" "64.4" "65.3" "60.0" "54.3" "64.6" "60.9" "62.0" "82.0" "72.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3368406966191061341" "False" "High" "IsMasterProtein" "Q9Y5X0" "Sorting nexin-10 OS=Homo sapiens OX=9606 GN=SNX10 PE=1 SV=2" "0.000" "False" "8.992" "12" "2" "2" "2" "201" "23.6" "5.78" "6.41" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "29887" "ENSG00000086300" "SNX10" "E9PFH5; hsa:29887; Q8IYT5; Q9Y5X0" "" "Autosomal recessive osteopetrosis pathways" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9220853686183247090" "False" "High" "IsMasterProtein" "Cont_P01966" "Hemoglobin subunit alpha OS=Bos taurus OX=9913 GN=HBA PE=1 SV=2" "0.000" "True" "8.976" "15" "2" "2" "2" "142" "15.2" "8.44" "6.16" "2" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "100140149; 109578761; 512439" "ENSBIXG00000028763; ENSBIXG00005026352; ENSBTAG00000051412" "GLNC1; HBA; LOC109578761; LOC113883300" "A0A1K0FUD3; A0A4W2IFB1; A0A6P5DZW6; A3KN13; biu:109578761; bta:100140149; bta:512439; P01966; Q3SZE0; Q9TTR9; Q9TTS0; Q9TTS1" "Cytoprotection by HMOX1; Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Heme signaling; Erythrocytes take up oxygen and release carbon dioxide" "" "5" "0" "1.074" "0.924" "1.100" "1.147" "1.023" "1.063" "0.912" "0.870" "0.973" "27.8" "29.9" "25.7" "30.6" "31.9" "28.5" "29.6" "25.4" "24.2" "27.1" "" "" "" "" "" "" "" "" "" "" "22.3" "21.6" "20.4" "20.5" "22.1" "21.4" "20.7" "18.5" "24.2" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7857168411920132290" "False" "High" "IsMasterProtein" "Q9Y5B8" "Nucleoside diphosphate kinase homolog 7 OS=Homo sapiens OX=9606 GN=NME7 PE=1 SV=1" "0.000" "False" "8.974" "7" "2" "2" "2" "376" "42.5" "6.47" "5.73" "2" "other metabolic processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00334" "29922" "ENSG00000143156" "NME7" "A8K3T6; A8MY09; B3KSW9; hsa:29922; Q5TGZ4; Q9Y5B8" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Pyrimidine metabolism; Ciliopathies" "4" "0" "1.082" "1.073" "1.041" "1.076" "1.120" "1.088" "1.206" "1.028" "1.112" "157.2" "170.0" "168.7" "163.6" "169.2" "176.1" "171.0" "189.5" "161.5" "174.7" "" "" "" "" "" "" "" "" "" "" "126.2" "122.7" "134.0" "109.6" "117.0" "132.1" "119.7" "138.4" "161.5" "142.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-621581403936215319" "False" "High" "IsMasterProtein" "Q96B36" "Proline-rich AKT1 substrate 1 OS=Homo sapiens OX=9606 GN=AKT1S1 PE=1 SV=1" "0.000" "False" "8.970" "9" "2" "2" "2" "256" "27.4" "4.75" "7.88" "2" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf15798" "84335" "ENSG00000204673" "AKT1S1" "A8MTQ1; B2RE93; hsa:84335; J3KPM3; Q96B36; Q96BI4; Q96IK7; Q96NG2; Q9BWR5" "Constitutive Signaling by AKT1 E17K in Cancer; mTORC1-mediated signalling; AKT phosphorylates targets in the cytosol; HSF1-dependent transactivation" "Target of rapamycin signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP" "22" "0" "0.866" "1.050" "1.073" "0.979" "1.047" "0.994" "0.884" "1.013" "1.041" "235.4" "203.9" "247.1" "252.5" "230.5" "246.4" "233.9" "208.0" "238.5" "245.0" "" "" "" "" "" "" "" "" "" "" "189.0" "147.1" "196.3" "169.2" "159.4" "184.9" "163.7" "151.9" "238.5" "199.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3090856641429635389" "False" "High" "IsMasterProtein" "Q16637" "Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN2 PE=1 SV=1" "0.000" "False" "8.968" "6" "1" "1" "1" "294" "31.8" "6.55" "4.47" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06003, Pf20635, Pf20636" "6606; 6607" "ENSG00000172062; ENSG00000205571; ENSG00000273772; ENSG00000275349; ENSG00000277773" "SMN1; SMN2" "A8K0V4; hsa:6606; hsa:6607; Q13119; Q16637; Q549U5; Q96J51" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "1.005" "0.850" "0.926" "0.787" "0.975" "0.848" "0.869" "0.853" "0.791" "141.7" "142.4" "120.5" "131.2" "111.6" "138.2" "120.2" "123.2" "120.9" "112.1" "" "" "" "" "" "" "" "" "" "" "113.8" "102.8" "95.7" "87.9" "77.2" "103.7" "84.1" "90.0" "120.9" "91.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334556934018890015" "False" "High" "IsMasterProtein" "P51808" "Dynein light chain Tctex-type 3 OS=Homo sapiens OX=9606 GN=DYNLT3 PE=1 SV=1" "0.000" "False" "8.961" "15" "1" "1" "1" "116" "13.1" "5.66" "5.82" "1" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03645" "6990" "ENSG00000165169" "DYNLT3" "hsa:6990; P51808; Q6ICS3" "" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Orexin receptor pathway" "4" "0" "0.991" "0.863" "0.976" "0.993" "0.918" "0.924" "1.000" "0.920" "0.903" "212.0" "210.1" "183.0" "206.8" "210.5" "194.6" "195.9" "211.9" "195.0" "191.4" "" "" "" "" "" "" "" "" "" "" "170.2" "151.6" "145.3" "138.6" "145.6" "146.0" "137.2" "154.8" "195.0" "155.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9189940377941500292" "False" "High" "IsMasterProtein" "Q9Y3D6" "Mitochondrial fission 1 protein OS=Homo sapiens OX=9606 GN=FIS1 PE=1 SV=2" "0.000" "False" "8.959" "9" "1" "4" "1" "152" "16.9" "8.79" "12.45" "1" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14852, Pf14853" "51024" "ENSG00000214253" "FIS1" "hsa:51024; Q9BTP3; Q9Y3D6" "Class I peroxisomal membrane protein import" "CAMKK2 pathway" "2" "0" "1.205" "1.180" "0.888" "0.929" "1.212" "1.205" "0.999" "1.028" "1.266" "46.8" "56.4" "55.3" "41.6" "43.5" "56.8" "56.5" "46.8" "48.2" "59.3" "" "" "" "" "" "" "" "" "" "" "37.6" "40.7" "43.9" "27.9" "30.1" "42.6" "39.5" "34.2" "48.2" "48.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2890344552958539961" "False" "High" "IsMasterProtein" "O75569" "Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Homo sapiens OX=9606 GN=PRKRA PE=1 SV=1" "0.000" "False" "8.954" "5" "1" "1" "1" "313" "34.4" "8.41" "5.77" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035" "8575" "ENSG00000180228" "PRKRA" "A8K3I6; hsa:8575; O75569; Q53G24; Q6X7T5; Q8NDK4" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "VEGFA-VEGFR2 signaling; Ebola virus infection in host" "5" "0" "1.125" "0.980" "1.033" "1.168" "1.157" "1.002" "1.012" "1.014" "1.085" "152.4" "171.5" "149.4" "157.4" "178.0" "176.4" "152.8" "154.3" "154.6" "165.4" "" "" "" "" "" "" "" "" "" "" "122.4" "123.8" "118.6" "105.5" "123.1" "132.4" "107.0" "112.7" "154.6" "134.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6516926494884828082" "False" "High" "IsMasterProtein" "Q7RTR2" "NLR family CARD domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NLRC3 PE=1 SV=2" "0.000" "False" "8.948" "3" "3" "3" "3" "1065" "114.6" "8.29" "9.48" "3" "signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05729, Pf13516, Pf17776, Pf17779" "197358" "ENSG00000167984" "NLRC3" "hsa:197358; Q5EY36; Q7RTR2; Q8NF48; Q8NI01; Q8NI02; Q8TEL3" "IRF3-mediated induction of type I IFN" "" "1" "0" "0.950" "0.987" "1.011" "0.909" "0.886" "1.064" "1.068" "1.117" "0.941" "99.2" "94.2" "97.8" "100.2" "90.1" "87.9" "105.5" "105.9" "110.8" "93.4" "" "" "" "" "" "" "" "" "" "" "79.7" "68.0" "77.7" "67.2" "62.3" "65.9" "73.9" "77.4" "110.8" "75.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2661255315618113722" "False" "High" "IsMasterProtein" "O43493" "Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4" "0.000" "False" "8.942" "3" "1" "2" "1" "437" "45.9" "5.63" "6.14" "1" "" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "" "Pf17818" "10618" "ENSG00000152291; ENSG00000292253" "TGOLN2" "B2R686; B8ZZ88; D6W5K3; F8W8W7; F8WBK2; hsa:10618; J3KQ45; O15282; O43492; O43493; O43499; O43500; O43501; Q53G68; Q53GV2; Q6MZV1; Q6ZTM7; Q8N6T8; Q92760; Q96QL2" "Golgi Associated Vesicle Biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "" "6" "0" "1.036" "1.174" "1.218" "1.149" "0.843" "1.263" "1.006" "1.001" "0.976" "33.2" "34.4" "39.0" "40.5" "38.2" "28.0" "41.9" "33.4" "33.2" "32.4" "" "" "" "" "" "" "" "" "" "" "26.7" "24.8" "31.0" "27.1" "26.4" "21.0" "29.4" "24.4" "33.2" "26.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8231689482753176423" "False" "High" "IsMasterProtein" "Q5T9C2" "Early estrogen-induced gene 1 protein OS=Homo sapiens OX=9606 GN=EEIG1 PE=1 SV=2" "0.000" "False" "8.934" "6" "2" "2" "2" "384" "41.8" "8.56" "6.83" "2" "other biological processes" "other membranes;nucleus;other cell component" "" "Pf10358" "399665" "ENSG00000167106" "EEIG1" "A2A329; hsa:399665; Q5T9C2; Q8TEL4" "" "" "0" "0" "1.194" "1.103" "1.228" "0.951" "1.029" "1.238" "1.074" "1.038" "1.115" "113.6" "135.6" "125.3" "139.5" "108.1" "117.0" "140.6" "122.0" "117.9" "126.8" "" "" "" "" "" "" "" "" "" "" "91.3" "97.9" "99.5" "93.5" "74.7" "87.8" "98.5" "89.1" "117.9" "103.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1663461843225663368" "False" "High" "IsMasterProtein" "O00716" "Transcription factor E2F3 OS=Homo sapiens OX=9606 GN=E2F3 PE=1 SV=1" "0.000" "False" "8.927" "4" "2" "2" "2" "465" "49.1" "5.44" "6.23" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1871" "ENSG00000112242" "E2F3" "hsa:1871; O00716; Q15000; Q68DT0; Q9BZ44" "Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)" "Cell cycle; Metastatic brain tumor; B cell receptor signaling pathway; Retinoblastoma gene in cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Small cell lung cancer; Melanoma; Nephrotic syndrome" "17" "0" "1.110" "0.944" "0.950" "1.029" "0.992" "1.168" "1.119" "1.217" "1.148" "92.0" "102.0" "86.8" "87.3" "94.6" "91.2" "107.4" "102.9" "111.9" "105.6" "" "" "" "" "" "" "" "" "" "" "73.9" "73.6" "69.0" "58.5" "65.4" "68.5" "75.2" "75.2" "111.9" "85.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699160270543076643" "False" "High" "IsMasterProtein" "Q14789" "Golgin subfamily B member 1 OS=Homo sapiens OX=9606 GN=GOLGB1 PE=1 SV=2" "0.000" "False" "8.923" "1" "2" "3" "2" "3259" "375.8" "5.00" "6.31" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "nucleic acid binding activity" "" "2804" "ENSG00000173230" "GOLGB1" "B2ZZ91; D3DN92; E7EP74; F1T0J2; hsa:2804; Q14398; Q14789" "Golgi Associated Vesicle Biogenesis; COPI-mediated anterograde transport; Signaling by FLT3 fusion proteins" "" "3" "0" "1.075" "0.917" "1.006" "1.019" "1.137" "0.918" "0.971" "0.993" "1.134" "164.1" "176.5" "150.5" "165.1" "167.2" "186.6" "150.7" "159.4" "162.9" "186.1" "" "" "" "" "" "" "" "" "" "" "131.8" "127.4" "119.5" "110.6" "115.6" "140.0" "105.5" "116.4" "162.9" "151.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5200285318932313306" "False" "High" "IsMasterProtein" "Q9UHR6" "Zinc finger HIT domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZNHIT2 PE=1 SV=1" "0.000" "False" "8.919" "9" "3" "3" "3" "403" "42.9" "5.99" "8.01" "3" "" "" "other molecular function" "Pf04438" "741" "ENSG00000174276" "ZNHIT2" "hsa:741; Q3SY14; Q8IUV0; Q9UHR6" "" "" "0" "0" "0.943" "0.918" "1.003" "0.951" "0.852" "0.849" "1.044" "0.893" "0.870" "68.4" "64.5" "62.8" "68.6" "65.1" "58.3" "58.1" "71.4" "61.1" "59.5" "" "" "" "" "" "" "" "" "" "" "54.9" "46.5" "49.9" "46.0" "45.0" "43.7" "40.7" "52.2" "61.1" "48.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8712581138028706155" "False" "High" "IsMasterProtein" "Cont_P02081" "Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1" "0.000" "True" "8.911" "21" "3" "3" "3" "145" "15.8" "7.03" "9.09" "3" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "104983812; 109569915; 109569938; 511735" "ENSBIXG00000000751; ENSBTAG00000038748" "LOC104983812; LOC109569915; LOC113905586" "A0A4W2CHH0; A0A6P3GXP4; A0A6P5D2L1; bbis:104983812; biu:109569915; biu:109569938; bta:511735; P02081; Q3SX09" "" "" "0" "0" "1.271" "0.996" "1.354" "1.364" "1.218" "1.272" "1.192" "1.160" "1.212" "126.5" "160.7" "125.9" "171.2" "172.5" "154.0" "160.9" "150.8" "146.7" "153.3" "" "" "" "" "" "" "" "" "" "" "101.6" "115.9" "100.0" "114.7" "119.3" "115.6" "112.6" "110.1" "146.7" "124.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1220366376593556815" "False" "High" "IsMasterProtein" "Q9Y5U2" "U5 small nuclear ribonucleoprotein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3" "0.000" "False" "8.907" "13" "4" "5" "4" "329" "34.3" "5.19" "12.44" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15264" "10078" "ENSG00000184281" "TSSC4" "C9JS66; hsa:10078; Q86VL2; Q9BRS6; Q9Y5U2" "" "" "0" "0" "0.950" "0.803" "1.043" "1.079" "1.070" "0.992" "1.073" "1.103" "0.964" "91.5" "86.9" "73.5" "95.4" "98.7" "97.9" "90.7" "98.2" "100.9" "88.2" "" "" "" "" "" "" "" "" "" "" "73.5" "62.7" "58.4" "63.9" "68.3" "73.4" "63.5" "71.7" "100.9" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139245110499108060" "False" "High" "IsMasterProtein" "P32942" "Intercellular adhesion molecule 3 OS=Homo sapiens OX=9606 GN=ICAM3 PE=1 SV=2" "0.000" "False" "8.899" "8" "4" "4" "4" "547" "59.5" "5.43" "11.71" "4" "cell adhesion;transport" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf03921, Pf21146" "3385" "ENSG00000076662" "ICAM3" "hsa:3385; P32942; Q6PD68" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; CD209 (DC-SIGN) signaling" "Ebola virus infection in host" "4" "0" "0.952" "0.939" "0.872" "0.922" "1.111" "0.966" "0.785" "0.973" "0.968" "404.1" "384.7" "379.4" "352.4" "372.5" "448.9" "390.4" "317.3" "393.4" "391.2" "" "" "" "" "" "" "" "" "" "" "324.6" "277.6" "301.4" "236.1" "257.6" "336.8" "273.3" "231.7" "393.4" "318.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7056878073192047652" "False" "High" "IsMasterProtein" "Q96JM7" "Lethal(3)malignant brain tumor-like protein 3 OS=Homo sapiens OX=9606 GN=L3MBTL3 PE=1 SV=2" "0.000" "False" "8.892" "2" "2" "2" "2" "780" "88.3" "6.46" "6.31" "2" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820" "84456" "ENSG00000198945" "L3MBTL3" "hsa:84456; Q4VXE1; Q5VUM9; Q6P9B5; Q96JM7" "" "" "0" "0" "1.229" "1.300" "1.290" "1.553" "1.476" "1.402" "1.301" "1.403" "1.437" "49.0" "60.1" "63.6" "63.2" "76.0" "72.2" "68.6" "63.7" "68.7" "70.4" "" "" "" "" "" "" "" "" "" "" "39.3" "43.4" "50.5" "42.3" "52.6" "54.2" "48.1" "46.5" "68.7" "57.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1354238916064112101" "False" "High" "IsMasterProtein" "Q5T6V5" "Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Homo sapiens OX=9606 GN=QNG1 PE=1 SV=1" "0.000" "False" "8.891" "9" "3" "3" "3" "341" "39.0" "5.88" "8.98" "3" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf10343" "84267" "ENSG00000165118" "QNG1" "B2RPI6; hsa:84267; Q5T6V5; Q8N2B1; Q9BT18" "" "" "0" "0" "1.124" "1.130" "1.437" "1.053" "1.326" "1.317" "1.268" "1.259" "1.327" "58.5" "65.7" "66.1" "84.0" "61.6" "77.5" "77.0" "74.2" "73.6" "77.6" "" "" "" "" "" "" "" "" "" "" "47.0" "47.4" "52.5" "56.3" "42.6" "58.2" "53.9" "54.2" "73.6" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3230263422708412736" "False" "High" "IsMasterProtein" "Q6UWP8" "Suprabasin OS=Homo sapiens OX=9606 GN=SBSN PE=1 SV=2" "0.000" "False" "8.889" "6" "1" "2" "1" "590" "60.5" "7.01" "6.15" "1" "" "" "" "Pf21009" "374897" "ENSG00000189001" "SBSN" "A8K5J0; E9PBV3; hsa:374897; Q6UWP8" "" "" "0" "0" "1.240" "1.180" "1.301" "0.938" "1.025" "1.120" "1.286" "1.473" "1.017" "23.3" "28.9" "27.5" "30.3" "21.8" "23.9" "26.1" "29.9" "34.3" "23.7" "" "" "" "" "" "" "" "" "" "" "18.7" "20.8" "21.8" "20.3" "15.1" "17.9" "18.3" "21.9" "34.3" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4531671785395663771" "False" "High" "IsMasterProtein" "Q5SXM8" "DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1" "0.000" "False" "8.879" "8" "1" "1" "1" "178" "19.2" "9.80" "5.68" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf05180" "728489" "ENSG00000213221" "DNLZ" "B2RUX5; B9EJE1; hsa:728489; Q5SXM8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340426752017437712" "False" "High" "IsMasterProtein" "Q9H8E8" "Cysteine-rich protein 2-binding protein OS=Homo sapiens OX=9606 GN=KAT14 PE=1 SV=3" "0.000" "False" "8.857" "3" "3" "3" "3" "782" "88.8" "6.57" "8.82" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00583" "57325" "ENSG00000149474" "KAT14" "A2A2I5; hsa:57325; Q96GW6; Q96IH3; Q9H8E8; Q9HBF0; Q9UIY5" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "1.078" "1.075" "1.023" "1.013" "1.087" "1.000" "0.945" "1.090" "1.060" "211.1" "227.6" "226.9" "216.0" "213.9" "229.4" "211.1" "199.5" "230.2" "223.8" "" "" "" "" "" "" "" "" "" "" "169.6" "164.2" "180.2" "144.7" "148.0" "172.1" "147.8" "145.7" "230.2" "182.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3178523695898665962" "False" "High" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "0.000" "False" "8.855" "4" "3" "3" "3" "920" "106.1" "9.98" "5.98" "3" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "" "Interactome of polycomb repressive complex 2 (PRC2)" "1" "0" "0.757" "0.843" "0.884" "0.846" "0.842" "0.929" "0.976" "0.897" "0.937" "226.3" "171.4" "190.7" "200.0" "191.6" "190.6" "210.3" "221.0" "203.0" "212.2" "" "" "" "" "" "" "" "" "" "" "181.8" "123.7" "151.5" "134.0" "132.5" "143.0" "147.2" "161.4" "203.0" "172.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650115712195666745" "False" "High" "IsMasterProtein" "Q9UIA0" "Cytohesin-4 OS=Homo sapiens OX=9606 GN=CYTH4 PE=1 SV=1" "0.000" "False" "8.841" "7" "3" "3" "3" "394" "45.6" "6.47" "9.64" "3" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "27128" "ENSG00000100055" "CYTH4" "hsa:27128; Q5R3F9; Q9UGT6; Q9UIA0" "Intra-Golgi traffic" "2q37 copy number variation syndrome" "2" "0" "0.941" "0.956" "1.020" "0.928" "0.903" "0.966" "1.008" "0.968" "0.941" "179.9" "169.3" "172.0" "183.5" "166.9" "162.4" "173.9" "181.3" "174.1" "169.3" "" "" "" "" "" "" "" "" "" "" "144.5" "122.2" "136.7" "122.9" "115.5" "121.9" "121.7" "132.4" "174.1" "137.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3153284644791767852" "False" "High" "IsMasterProtein" "Q9NX05" "Constitutive coactivator of PPAR-gamma-like protein 2 OS=Homo sapiens OX=9606 GN=FAM120C PE=1 SV=4" "0.000" "False" "8.829" "2" "2" "3" "2" "1096" "120.5" "9.03" "7.18" "2" "" "nucleus" "" "" "54954" "ENSG00000184083" "FAM120C" "B2RMT7; hsa:54954; Q9NX05" "" "" "0" "0" "1.029" "1.020" "1.039" "1.073" "1.086" "1.012" "1.102" "1.022" "1.048" "170.7" "175.5" "174.0" "177.3" "183.1" "185.4" "172.7" "188.1" "174.3" "178.9" "" "" "" "" "" "" "" "" "" "" "137.1" "126.7" "138.2" "118.8" "126.6" "139.1" "120.9" "137.3" "174.3" "145.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8228520515990444104" "False" "High" "IsMasterProtein" "Q8N3J3" "Homologous recombination OB-fold protein OS=Homo sapiens OX=9606 GN=HROB PE=1 SV=1" "0.000" "False" "8.818" "5" "3" "4" "3" "647" "69.7" "6.23" "7.85" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15072" "78995" "ENSG00000125319" "HROB" "A8K7A9; hsa:78995; Q8N3J3; Q9BWM9; Q9HAI1" "" "" "0" "0" "0.890" "0.802" "0.982" "1.042" "0.966" "1.089" "0.969" "0.965" "0.985" "46.6" "41.5" "37.4" "45.8" "48.6" "45.1" "50.8" "45.2" "45.0" "45.9" "" "" "" "" "" "" "" "" "" "" "37.5" "29.9" "29.7" "30.7" "33.6" "33.8" "35.6" "33.0" "45.0" "37.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2106052778808331693" "False" "High" "IsMasterProtein" "P62910" "Large ribosomal subunit protein eL32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2" "0.000" "False" "8.812" "21" "3" "4" "3" "135" "15.9" "11.33" "8.17" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01655" "6161" "ENSG00000144713" "RPL32" "B2R4Q3; hsa:6161; P02433; P62910" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6622895814543661851" "False" "High" "IsMasterProtein" "O15504" "Nucleoporin NUP42 OS=Homo sapiens OX=9606 GN=NUP42 PE=1 SV=1" "0.000" "False" "8.806" "8" "4" "5" "4" "423" "44.8" "9.19" "11.93" "4" "transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf18044" "11097" "ENSG00000136243" "NUP42" "A4D143; B4DP42; hsa:11097; O15504; Q49AE7; Q9BS49" "HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "790409286945352523" "False" "High" "IsMasterProtein" "O14893" "Gem-associated protein 2 OS=Homo sapiens OX=9606 GN=GEMIN2 PE=1 SV=1" "0.000" "False" "8.805" "18" "3" "3" "3" "280" "31.6" "5.58" "8.75" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04938" "8487" "ENSG00000092208" "GEMIN2" "B2R9W8; hsa:8487; O14893; Q2M3B3; Q9H4F5; Q9NS77; Q9NS78; Q9NS79" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "0.980" "0.888" "1.027" "0.754" "0.902" "0.816" "0.636" "0.797" "0.887" "94.0" "92.1" "83.5" "96.5" "70.8" "84.7" "76.7" "59.7" "74.9" "83.4" "" "" "" "" "" "" "" "" "" "" "75.5" "66.4" "66.3" "64.6" "49.0" "63.6" "53.7" "43.6" "74.9" "67.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5958552957432297313" "False" "High" "IsMasterProtein" "Q9BRJ6" "Uncharacterized protein C7orf50 OS=Homo sapiens OX=9606 GN=C7orf50 PE=1 SV=1" "0.000" "False" "8.802" "14" "2" "3" "2" "194" "22.1" "9.64" "8.07" "2" "" "" "" "Pf10180" "84310" "ENSG00000146540" "C7orf50" "Q9BRJ6" "" "" "0" "0" "1.048" "1.111" "1.217" "1.150" "1.069" "1.414" "1.113" "1.139" "1.110" "47.2" "49.5" "52.5" "57.5" "54.3" "50.5" "66.8" "52.6" "53.8" "52.4" "" "" "" "" "" "" "" "" "" "" "37.9" "35.7" "41.7" "38.5" "37.6" "37.9" "46.8" "38.4" "53.8" "42.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6543857744544751788" "False" "High" "IsMasterProtein" "P38571" "Lysosomal acid lipase/cholesteryl ester hydrolase OS=Homo sapiens OX=9606 GN=LIPA PE=1 SV=2" "0.000" "False" "8.797" "7" "3" "3" "3" "399" "45.4" "6.92" "8.73" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00561" "3988" "ENSG00000107798" "LIPA" "B2RBH5; D3DR29; hsa:3988; P38571; Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0" "LDL clearance" "Phase I biotransformations, non-P450; Degradation pathway of sphingolipids, including diseases; Cholesterol metabolism" "4" "0" "1.023" "0.980" "1.155" "1.020" "0.996" "1.066" "1.031" "0.933" "1.025" "401.1" "410.3" "393.1" "463.0" "409.0" "399.4" "427.7" "413.6" "374.2" "411.1" "" "" "" "" "" "" "" "" "" "" "322.1" "296.1" "312.3" "310.2" "282.8" "299.7" "299.4" "302.0" "374.2" "334.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1428811385271777844" "False" "High" "IsMasterProtein" "Q9H488" "GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1" "0.000" "False" "8.793" "5" "2" "3" "2" "388" "43.9" "8.53" "8.71" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23509" "ENSG00000101346" "POFUT1" "A8K4R8; E1P5M4; hsa:23509; Q14685; Q5W185; Q9BW76; Q9H488" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "" "1" "0" "1.045" "0.811" "0.998" "0.965" "0.951" "1.054" "1.018" "0.956" "0.982" "202.1" "211.2" "163.8" "201.7" "195.0" "192.2" "213.0" "205.6" "193.1" "198.4" "" "" "" "" "" "" "" "" "" "" "162.3" "152.4" "130.1" "135.1" "134.9" "144.2" "149.1" "150.2" "193.1" "161.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2912767912009988876" "False" "High" "IsMasterProtein" "Q8TCE6" "DENN domain-containing protein 10 OS=Homo sapiens OX=9606 GN=DENND10 PE=1 SV=1" "0.000" "False" "8.791" "6" "2" "2" "2" "357" "40.5" "6.61" "5.88" "2" "transport;other biological processes" "other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf08616" "404636" "ENSG00000119979" "DENND10" "B1AMV6; B4DDC3; D3DRC8; hsa:404636; Q8TCE6; Q9NXW4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2534211096191502147" "False" "High" "IsMasterProtein" "O00560" "Syntenin-1 OS=Homo sapiens OX=9606 GN=SDCBP PE=1 SV=1" "0.000" "False" "8.781" "10" "2" "3" "2" "298" "32.4" "7.53" "10.01" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595" "6386" "ENSG00000137575" "SDCBP" "B2R5Q7; B4DUH3; B7ZLN2; O00173; O00560; O43391; Q14CP2" "Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death" "Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling; 11p11.2 copy number variation syndrome" "9" "0" "1.025" "0.985" "1.091" "1.095" "0.929" "1.074" "1.070" "1.019" "1.263" "135.3" "138.6" "133.2" "147.6" "148.1" "125.6" "145.3" "144.7" "137.9" "170.8" "" "" "" "" "" "" "" "" "" "" "108.6" "100.0" "105.8" "98.9" "102.4" "94.2" "101.7" "105.7" "137.9" "138.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-404480449398085068" "False" "High" "IsMasterProtein" "P51809" "Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3" "0.000" "False" "8.778" "15" "4" "5" "4" "220" "24.9" "8.60" "13.35" "4" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "6845" "ENSG00000124333; ENSG00000292366" "VAMP7" "hsa:6845; P51809; Q53GY7; Q7Z409; Q9H4A7" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Interleukin-12 signaling" "" "6" "0" "0.915" "0.943" "0.863" "0.941" "0.932" "0.905" "0.867" "0.784" "0.859" "243.2" "222.4" "229.4" "209.8" "228.9" "226.6" "220.2" "211.0" "190.6" "208.9" "" "" "" "" "" "" "" "" "" "" "195.3" "160.5" "182.2" "140.6" "158.3" "170.0" "154.1" "154.1" "190.6" "169.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5589324606331654897" "False" "High" "IsMasterProtein" "Q6P161" "Large ribosomal subunit protein mL54 OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "0.000" "False" "8.774" "14" "2" "2" "2" "138" "15.8" "9.60" "7.25" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.014" "1.083" "1.067" "1.023" "0.948" "1.049" "0.994" "0.943" "0.979" "442.7" "448.8" "479.3" "472.4" "452.9" "419.8" "464.5" "439.9" "417.4" "433.5" "" "" "" "" "" "" "" "" "" "" "355.5" "323.9" "380.7" "316.5" "313.2" "314.9" "325.2" "321.2" "417.4" "352.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "96536570714027089" "False" "High" "IsMasterProtein" "Q99728" "BRCA1-associated RING domain protein 1 OS=Homo sapiens OX=9606 GN=BARD1 PE=1 SV=2" "0.000" "False" "8.765" "3" "2" "2" "2" "777" "86.6" "8.72" "6.36" "2" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00533, Pf14835" "580" "ENSG00000138376" "BARD1" "F6MDH7; F6MDH8; F6MDH9; hsa:580; O43574; Q53SS5; Q99728" "Nonhomologous End-Joining (NHEJ); UCH proteinases; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Defective DNA double strand break response due to BRCA1 loss of function; Defective DNA double strand break response due to BARD1 loss of function" "Retinoblastoma gene in cancer; Pleural mesothelioma; 5q35 copy number variation" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "996701164361086035" "False" "High" "IsMasterProtein" "Q96E29" "Transcription termination factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF3 PE=1 SV=2" "0.000" "False" "8.763" "10" "3" "4" "3" "417" "47.9" "8.53" "12.34" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "nucleic acid binding activity" "Pf02536" "51001" "ENSG00000156469" "MTERF3" "B3KMG6; G3V130; hsa:51001; Q96E29; Q9Y301" "PINK1-PRKN Mediated Mitophagy" "Mitochondrial gene expression" "2" "0" "1.032" "0.960" "0.969" "0.983" "1.049" "0.947" "1.072" "0.985" "0.988" "106.9" "110.3" "102.6" "103.5" "105.1" "112.1" "101.2" "114.5" "105.3" "105.6" "" "" "" "" "" "" "" "" "" "" "85.8" "79.6" "81.5" "69.4" "72.7" "84.1" "70.9" "83.6" "105.3" "85.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3935713179938084537" "False" "High" "IsMasterProtein" "Q96HP4" "Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1" "0.000" "False" "8.742" "10" "3" "3" "3" "312" "34.8" "8.37" "9.59" "3" "" "" "other molecular function" "Pf00175" "92106" "ENSG00000154814" "OXNAD1" "hsa:92106; Q2HYC7; Q59FA4; Q96HP4" "" "" "0" "0" "1.106" "0.958" "1.091" "1.050" "1.090" "0.992" "1.070" "1.082" "1.024" "253.3" "280.2" "242.6" "276.3" "266.1" "276.2" "251.4" "271.0" "274.2" "259.4" "" "" "" "" "" "" "" "" "" "" "203.5" "202.2" "192.7" "185.1" "184.0" "207.2" "176.0" "197.9" "274.2" "211.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6761620060411252827" "False" "High" "IsMasterProtein" "Q9HBH0" "Rho-related GTP-binding protein RhoF OS=Homo sapiens OX=9606 GN=RHOF PE=1 SV=1" "0.000" "False" "8.738" "17" "3" "3" "3" "211" "23.6" "8.65" "6.74" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "enzyme regulator activity;other molecular function" "Pf00071" "54509" "ENSG00000139725" "RHOF" "hsa:54509; Q8WVB1; Q9HBH0; Q9NXH6" "Neutrophil degranulation; RHOF GTPase cycle" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "278925375883264414" "False" "High" "IsMasterProtein" "P23610" "40-kDa huntingtin-associated protein OS=Homo sapiens OX=9606 GN=F8A3 PE=1 SV=2" "0.000" "False" "8.732" "4" "1" "1" "1" "371" "39.1" "6.84" "4.94" "1" "transport;other biological processes" "nucleus;other cytoplasmic organelle" "" "" "474383; 474384; 8263" "ENSG00000277150; ENSG00000288709; ENSG00000288722" "F8A1; F8A2; F8A3" "hsa:474383; hsa:474384; hsa:8263; P23610; Q5HY66; Q8IXP3" "" "" "0" "0" "1.123" "1.030" "1.077" "1.118" "0.975" "1.047" "1.081" "1.078" "1.155" "81.4" "91.4" "83.8" "87.6" "91.0" "79.3" "85.2" "87.9" "87.7" "94.0" "" "" "" "" "" "" "" "" "" "" "65.3" "65.9" "66.6" "58.7" "62.9" "59.5" "59.7" "64.2" "87.7" "76.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588052474242389854" "False" "High" "IsMasterProtein" "Q92766" "Ras-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=RREB1 PE=1 SV=3" "0.000" "False" "8.729" "1" "2" "2" "1" "1687" "181.3" "6.98" "6.64" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894, Pf13912" "6239" "ENSG00000124782" "RREB1" "A2RRF5; E2GM80; E2GM81; hsa:6239; O75567; O75568; Q5VYB2; Q6BEP5; Q6BEP6; Q6BEP8; Q86SU2; Q92766; Q9Y474" "" "" "0" "0" "0.943" "0.930" "1.134" "0.976" "0.737" "1.003" "0.984" "1.062" "0.860" "56.3" "53.1" "52.4" "63.9" "54.9" "41.5" "56.5" "55.4" "59.8" "48.4" "" "" "" "" "" "" "" "" "" "" "45.2" "38.3" "41.6" "42.8" "38.0" "31.1" "39.5" "40.5" "59.8" "39.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "257698658833668232" "False" "High" "IsMasterProtein" "A7E2V4" "Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZSWIM8 PE=1 SV=1" "0.000" "False" "8.726" "1" "2" "2" "2" "1837" "197.2" "6.80" "6.91" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf21055" "23053" "ENSG00000214655" "ZSWIM8" "A7E2V4; B2RP37; hsa:23053; O94987; Q17RS8; Q2TAB8; Q6P439; Q8IW81; Q8NB34; Q9H8F3" "Regulation of expression of SLITs and ROBOs" "" "1" "0" "0.927" "0.972" "1.298" "0.970" "0.980" "1.005" "1.096" "1.047" "1.015" "113.3" "105.1" "110.1" "147.0" "109.9" "111.0" "113.9" "124.2" "118.7" "115.0" "" "" "" "" "" "" "" "" "" "" "91.0" "75.8" "87.5" "98.5" "76.0" "83.3" "79.7" "90.7" "118.7" "93.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6959093533306709871" "False" "High" "IsMasterProtein" "P0DPD7" "EEF1A lysine methyltransferase 4 OS=Homo sapiens OX=9606 GN=EEF1AKMT4 PE=1 SV=1" "0.000" "False" "8.726" "9" "2" "3" "2" "255" "28.3" "6.05" "6.72" "2" "other metabolic processes" "" "other molecular function" "Pf08241" "110599564" "ENSG00000284753" "EEF1AKMT4" "A5PLK8; hsa:110599564; O60344; P0DPD7; Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8998736333335138172" "False" "High" "IsMasterProtein" "Q08623" "Pseudouridine-5'-phosphatase OS=Homo sapiens OX=9606 GN=PUDP PE=1 SV=3" "0.000" "False" "8.712" "4" "1" "3" "1" "228" "25.2" "5.31" "10.67" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf13419" "8226" "ENSG00000130021" "PUDP" "B2R7X6; B4DV93; B7Z6Q3; E9PAV8; F5GWZ2; hsa:8226; Q08623; Q53F84; Q96EB8" "Pyrimidine salvage" "" "1" "0" "0.904" "0.917" "0.791" "0.865" "0.946" "0.866" "0.803" "0.857" "0.866" "346.4" "313.1" "317.5" "273.8" "299.5" "327.7" "299.9" "278.0" "296.8" "299.9" "" "" "" "" "" "" "" "" "" "" "278.2" "225.9" "252.2" "183.5" "207.1" "245.9" "210.0" "203.0" "296.8" "243.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6883874888390724890" "False" "High" "IsMasterProtein" "Q5VTL8" "Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1" "0.000" "False" "8.711" "7" "4" "4" "4" "546" "64.4" "10.54" "9.35" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371" "55119" "ENSG00000134186" "PRPF38B" "hsa:55119; Q05DD6; Q32Q58; Q5VTL8; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40" "" "" "0" "0" "1.009" "1.232" "1.113" "1.088" "1.088" "1.019" "1.066" "1.170" "1.118" "196.7" "198.6" "242.3" "219.1" "214.0" "214.0" "200.5" "209.7" "230.1" "220.0" "" "" "" "" "" "" "" "" "" "" "158.0" "143.3" "192.5" "146.8" "148.0" "160.6" "140.4" "153.2" "230.1" "178.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-332338773626550486" "False" "High" "IsMasterProtein" "Q9BQI3" "Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Homo sapiens OX=9606 GN=EIF2AK1 PE=1 SV=2" "0.000" "False" "8.704" "5" "3" "3" "3" "630" "71.1" "5.99" "8.09" "3" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "27102" "ENSG00000086232" "EIF2AK1" "A8K2R2; hsa:27102; Q549K6; Q8NBW3; Q9BQI3; Q9HC02; Q9NYE0; Q9P0V6; Q9P1J5; Q9P2H8; Q9UHG4" "Response of EIF2AK1 (HRI) to heme deficiency; Cellular response to mitochondrial stress" "Translation factors; Measles virus infection" "4" "0" "0.987" "0.913" "0.998" "0.949" "0.915" "0.994" "1.026" "1.063" "1.228" "117.1" "115.6" "106.9" "116.8" "111.1" "107.2" "116.4" "120.2" "124.4" "143.7" "" "" "" "" "" "" "" "" "" "" "94.0" "83.4" "84.9" "78.2" "76.9" "80.4" "81.5" "87.8" "124.4" "116.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088626010110122517" "False" "High" "IsMasterProtein" "Q9UJX6" "Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1" "0.000" "False" "8.693" "3" "3" "3" "3" "822" "93.8" "5.22" "9.84" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00888, Pf08672" "29882" "ENSG00000176248" "ANAPC2" "hsa:29882; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1; Q9UJX6" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "582663252060756755" "False" "High" "IsMasterProtein" "Q9NVX7" "Kelch repeat and BTB domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KBTBD4 PE=1 SV=4" "0.000" "False" "8.677" "4" "2" "2" "2" "534" "59.9" "5.77" "7.46" "2" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.993" "0.983" "0.980" "0.906" "0.991" "1.017" "0.937" "0.989" "1.038" "144.6" "143.6" "142.1" "141.7" "131.0" "143.2" "147.1" "135.5" "143.0" "150.1" "" "" "" "" "" "" "" "" "" "" "116.1" "103.6" "112.9" "95.0" "90.6" "107.4" "103.0" "99.0" "143.0" "122.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2363903174010187196" "False" "High" "IsMasterProtein" "Q6W2J9" "BCL-6 corepressor OS=Homo sapiens OX=9606 GN=BCOR PE=1 SV=1" "0.000" "False" "8.674" "1" "1" "1" "1" "1755" "192.1" "6.48" "5.35" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12796, Pf15808, Pf16553" "54880" "ENSG00000183337" "BCOR" "D3DWB3; D3DWB4; hsa:54880; Q29RF6; Q6P4B6; Q6W2J9; Q7Z2K7; Q8TEB4; Q96DB3; Q9H232; Q9H233; Q9HCJ7; Q9NXF2" "" "Ectoderm differentiation; Pathways affected in adenoid cystic carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842637441270179392" "False" "High" "IsMasterProtein" "Q9BU76" "Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1" "0.000" "False" "8.670" "10" "2" "2" "2" "263" "29.4" "10.02" "6.00" "2" "" "non-structural extracellular;other cell component" "" "Pf10159" "79169" "ENSG00000143793" "MMTAG2" "hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76" "Neutrophil degranulation" "" "1" "0" "1.202" "1.080" "1.273" "1.214" "1.165" "1.337" "1.814" "1.119" "1.088" "19.3" "23.2" "20.9" "24.6" "23.4" "22.5" "25.8" "35.0" "21.6" "21.0" "" "" "" "" "" "" "" "" "" "" "15.5" "16.7" "16.6" "16.5" "16.2" "16.9" "18.1" "25.6" "21.6" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8162637103249760299" "False" "High" "IsMasterProtein" "Q14CB8" "Rho GTPase-activating protein 19 OS=Homo sapiens OX=9606 GN=ARHGAP19 PE=1 SV=1" "0.000" "False" "8.655" "7" "3" "3" "3" "494" "55.7" "9.36" "8.45" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "84986" "ENSG00000213390" "ARHGAP19" "A1XCP1; B4DZR1; hsa:84986; Q14CB8; Q14CF2; Q5J8M2; Q5T460; Q5T462; Q68DG6; Q8N9X1; Q8NF34; Q8TEK1" "RHOA GTPase cycle" "" "1" "0" "0.948" "0.984" "1.031" "1.020" "0.954" "1.152" "1.146" "1.158" "1.059" "217.5" "206.3" "213.9" "224.2" "221.9" "207.5" "250.5" "249.3" "251.8" "230.3" "" "" "" "" "" "" "" "" "" "" "174.7" "148.9" "169.9" "150.2" "153.5" "155.7" "175.4" "182.1" "251.8" "187.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "203506742472389879" "False" "High" "IsMasterProtein" "Q5RL73" "RNA-binding protein 48 OS=Homo sapiens OX=9606 GN=RBM48 PE=1 SV=1" "0.000" "False" "8.643" "6" "2" "2" "2" "367" "41.8" "8.72" "6.30" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "" "84060" "ENSG00000127993" "RBM48" "B7Z2K5; B7ZL51; hsa:84060; Q5H9T2; Q5RL73; Q8IYW7; Q96NS0; Q9H0V7" "" "" "0" "0" "1.011" "1.017" "1.049" "1.098" "0.968" "1.085" "0.951" "1.161" "1.068" "160.9" "162.7" "163.7" "168.7" "176.7" "155.8" "174.5" "152.9" "186.9" "171.9" "" "" "" "" "" "" "" "" "" "" "129.2" "117.4" "130.0" "113.0" "122.2" "116.9" "122.2" "111.7" "186.9" "139.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8682712823667695648" "False" "High" "IsMasterProtein" "Q7Z2E3" "Aprataxin OS=Homo sapiens OX=9606 GN=APTX PE=1 SV=2" "0.000" "False" "8.640" "7" "3" "4" "3" "356" "40.7" "9.17" "13.76" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11969, Pf16278, Pf17913" "54840" "ENSG00000137074" "APTX" "A8MTN4; D3DRK9; D3DRL0; hsa:54840; Q0P662; Q5T781; Q5T782; Q5T784; Q6JV81; Q6JV82; Q6JV85; Q7Z2E3; Q7Z2F3; Q7Z336; Q7Z5R5; Q7Z6V7; Q7Z6V8; Q9NXM5" "" "" "0" "0" "0.999" "0.887" "1.025" "1.050" "0.894" "1.106" "1.003" "0.994" "0.946" "85.0" "84.9" "75.4" "87.2" "89.3" "76.0" "94.1" "85.3" "84.5" "80.4" "" "" "" "" "" "" "" "" "" "" "68.3" "61.3" "59.9" "58.4" "61.8" "57.0" "65.9" "62.3" "84.5" "65.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4549046662216953457" "False" "High" "IsMasterProtein" "Q86XN7" "Proline and serine-rich protein 1 OS=Homo sapiens OX=9606 GN=PROSER1 PE=1 SV=2" "0.000" "False" "8.637" "3" "3" "3" "3" "944" "95.6" "8.88" "8.71" "3" "" "" "" "Pf14771" "80209" "ENSG00000120685" "PROSER1" "A6NJ97; hsa:80209; Q6P2S2; Q7Z3X5; Q86XN7; Q8N3D2; Q8N3P1; Q9H9M1" "" "" "0" "0" "1.024" "0.953" "0.960" "0.973" "0.934" "0.931" "1.006" "0.981" "0.936" "606.2" "620.9" "577.9" "581.7" "590.1" "566.0" "564.2" "609.6" "594.9" "567.3" "" "" "" "" "" "" "" "" "" "" "486.9" "448.0" "459.0" "389.8" "408.1" "424.7" "395.0" "445.2" "594.9" "461.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619075754329803082" "False" "High" "IsMasterProtein" "P17275" "Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1" "0.000" "False" "8.637" "10" "3" "3" "3" "347" "35.9" "9.22" "5.93" "3" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3726" "ENSG00000171223" "JUNB" "hsa:3726; P17275; Q96GH3" "NGF-stimulated transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Oxidative stress response; Host-pathogen interaction of human coronaviruses - MAPK signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "18" "0" "0.937" "0.879" "0.943" "1.063" "0.840" "1.126" "1.121" "1.151" "1.114" "149.3" "139.9" "131.2" "140.8" "158.7" "125.4" "168.1" "167.4" "171.8" "166.4" "" "" "" "" "" "" "" "" "" "" "119.9" "101.0" "104.3" "94.4" "109.8" "94.1" "117.7" "122.3" "171.8" "135.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4153058016593714536" "False" "High" "IsMasterProtein" "Q9UKT5" "F-box only protein 4 OS=Homo sapiens OX=9606 GN=FBXO4 PE=1 SV=2" "0.000" "False" "8.635" "5" "2" "3" "2" "387" "44.1" "6.16" "8.59" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646" "26272" "ENSG00000151876" "FBXO4" "hsa:26272; Q68CU8; Q86VT8; Q9UK98; Q9UKT5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "1.083" "1.053" "1.151" "1.061" "0.985" "0.923" "1.104" "1.026" "1.002" "198.7" "215.2" "209.2" "228.7" "210.9" "195.7" "183.4" "219.4" "203.9" "199.2" "" "" "" "" "" "" "" "" "" "" "159.6" "155.3" "166.2" "153.2" "145.9" "146.8" "128.4" "160.3" "203.9" "162.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9180192453950737945" "False" "High" "IsMasterProtein" "A0PJW8" "Death-associated protein-like 1 OS=Homo sapiens OX=9606 GN=DAPL1 PE=1 SV=2" "0.000" "False" "8.631" "23" "3" "3" "3" "107" "11.9" "9.99" "8.42" "3" "stress response;signal transduction;other biological processes" "" "translation activity;other molecular function" "Pf15228" "92196" "ENSG00000163331" "DAPL1" "A0PJW8; A0PJW9; B9EIK6; hsa:92196" "" "" "0" "0" "0.980" "0.938" "1.128" "1.251" "1.108" "1.363" "1.102" "1.179" "1.163" "239.8" "235.0" "225.0" "270.5" "299.9" "265.6" "326.8" "264.1" "282.7" "278.9" "" "" "" "" "" "" "" "" "" "" "192.6" "169.6" "178.7" "181.3" "207.4" "199.3" "228.8" "192.9" "282.7" "226.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3933155493213774730" "False" "High" "IsMasterProtein" "Cont_Q3SZV7" "Hemopexin OS=Bos taurus OX=9913 GN=HPX PE=2 SV=1" "0.000" "True" "8.606" "7" "4" "4" "4" "459" "52.2" "7.80" "11.27" "4" "other metabolic processes;transport;other biological processes" "non-structural extracellular" "transporter activity;other molecular function" "Pf00045" "534509" "ENSBIXG00000017851" "HPX" "A0A4W2EKG5; bta:534509; Q3SZV7" "" "" "0" "0" "0.849" "0.840" "1.076" "0.920" "1.040" "1.403" "0.893" "0.940" "0.999" "303.4" "257.6" "254.7" "326.4" "279.2" "315.5" "425.7" "271.0" "285.1" "303.0" "" "" "" "" "" "" "" "" "" "" "243.7" "185.9" "202.4" "218.7" "193.1" "236.7" "298.0" "197.9" "285.1" "246.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8617908927917494365" "False" "High" "IsMasterProtein" "O14639" "Actin-binding LIM protein 1 OS=Homo sapiens OX=9606 GN=ABLIM1 PE=1 SV=3" "0.000" "False" "8.605" "5" "3" "3" "3" "778" "87.6" "8.59" "8.43" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf02209, Pf16182" "3983" "ENSG00000099204" "ABLIM1" "A6NI16; A6NJ06; A8MXA9; B3KVH2; hsa:3983; O14639; Q15039; Q5JVV1; Q5JVV2; Q5T6N2; Q5T6N3; Q5T6N5; Q68CQ9; Q9BUP1" "DCC mediated attractive signaling" "Male infertility" "2" "0" "1.410" "1.237" "1.239" "1.262" "1.793" "1.238" "1.143" "1.113" "1.213" "11.4" "16.0" "14.1" "14.1" "14.4" "20.4" "14.1" "13.0" "12.7" "13.8" "" "" "" "" "" "" "" "" "" "" "9.1" "11.6" "11.2" "9.4" "9.9" "15.3" "9.9" "9.5" "12.7" "11.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014101916445181907" "False" "High" "IsMasterProtein" "Q6BDS2" "Bridge-like lipid transfer protein family member 3A OS=Homo sapiens OX=9606 GN=BLTP3A PE=1 SV=1" "0.000" "False" "8.594" "2" "3" "3" "3" "1440" "159.4" "6.14" "9.22" "3" "" "other cytoplasmic organelle" "other molecular function" "Pf12624" "54887" "ENSG00000065060" "BLTP3A" "hsa:54887; Q6BDS2; Q9NXE0" "" "" "0" "0" "1.083" "1.112" "0.995" "1.102" "0.985" "0.904" "1.103" "1.039" "1.053" "273.6" "296.3" "304.4" "272.3" "301.6" "269.4" "247.4" "301.8" "284.4" "288.1" "" "" "" "" "" "" "" "" "" "" "219.8" "213.8" "241.8" "182.5" "208.6" "202.1" "173.2" "220.4" "284.4" "234.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7557449725087676483" "False" "High" "IsMasterProtein" "Q3MIT2" "tRNA pseudouridine synthase Pus10 OS=Homo sapiens OX=9606 GN=PUS10 PE=1 SV=1" "0.000" "False" "8.588" "5" "3" "3" "3" "529" "60.2" "6.54" "6.70" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21237, Pf21238" "150962" "ENSG00000162927" "PUS10" "hsa:150962; Q3MIT2; Q5JPJ5; Q96MI8" "" "" "0" "0" "1.110" "1.053" "1.000" "0.972" "0.971" "0.986" "1.034" "1.088" "1.035" "146.1" "162.2" "153.9" "146.1" "142.0" "141.9" "144.0" "151.1" "159.0" "151.2" "" "" "" "" "" "" "" "" "" "" "117.4" "117.1" "122.2" "97.9" "98.2" "106.5" "100.9" "110.4" "159.0" "122.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5456206388273003181" "False" "High" "IsMasterProtein" "O95985" "DNA topoisomerase 3-beta-1 OS=Homo sapiens OX=9606 GN=TOP3B PE=1 SV=1" "0.000" "False" "8.577" "4" "3" "3" "2" "862" "96.6" "8.12" "9.46" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01751" "8940" "ENSG00000100038" "TOP3B" "A0M8Q3; hsa:8940; O95985; Q9BUP5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9085174644749999284" "False" "High" "IsMasterProtein" "Q4G0F5" "Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2" "0.000" "False" "8.561" "5" "2" "2" "1" "336" "39.1" "7.36" "6.62" "2" "stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "112936" "ENSG00000151502" "VPS26B" "hsa:112936; Q4G0F5; Q96A55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6620394605716673272" "False" "High" "IsMasterProtein" "Q96GX2" "Ataxin-7-like protein 3B OS=Homo sapiens OX=9606 GN=ATXN7L3B PE=1 SV=2" "0.000" "False" "8.542" "10" "1" "3" "1" "97" "10.8" "4.36" "7.03" "1" "other biological processes" "other cell component" "" "" "552889" "ENSG00000253719" "ATXN7L3B" "hsa:552889; Q96GX2" "" "" "0" "0" "0.963" "0.962" "0.934" "0.969" "1.068" "0.965" "1.053" "1.053" "1.012" "393.2" "378.5" "378.1" "367.2" "380.9" "419.8" "379.4" "414.1" "413.9" "397.8" "" "" "" "" "" "" "" "" "" "" "315.8" "273.1" "300.4" "246.1" "263.4" "315.0" "265.7" "302.4" "413.9" "323.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1450740357169926082" "False" "High" "IsMasterProtein" "P40121" "Macrophage-capping protein OS=Homo sapiens OX=9606 GN=CAPG PE=1 SV=2" "0.000" "False" "8.528" "5" "2" "2" "2" "348" "38.5" "6.19" "7.34" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "822" "ENSG00000042493" "CAPG" "B8ZZS7; D6W5K8; hsa:822; P40121; Q53SA7" "" "TYROBP causal network in microglia" "1" "0" "0.961" "1.014" "0.948" "1.066" "1.041" "0.971" "1.006" "1.073" "0.987" "365.6" "351.4" "370.9" "346.6" "389.6" "380.5" "355.0" "367.9" "392.4" "360.8" "" "" "" "" "" "" "" "" "" "" "293.7" "253.5" "294.6" "232.2" "269.5" "285.5" "248.5" "268.6" "392.4" "293.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3949732143901396407" "False" "High" "IsMasterProtein" "O43427" "Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3" "0.000" "False" "8.507" "6" "3" "4" "2" "364" "41.9" "6.48" "9.87" "3" "signal transduction" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05427" "9158" "ENSG00000172500" "FIBP" "A8K0J7; hsa:9158; O43427; Q27Q85; Q6IBQ3; Q9HD65" "" "Modulators of TCR signaling and T cell activation" "1" "0" "1.213" "1.231" "0.999" "1.159" "1.191" "0.932" "0.980" "0.932" "1.051" "48.8" "59.2" "60.1" "48.8" "56.6" "58.2" "45.5" "47.9" "45.5" "51.3" "" "" "" "" "" "" "" "" "" "" "39.2" "42.7" "47.7" "32.7" "39.1" "43.6" "31.9" "35.0" "45.5" "41.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825155014730555615" "False" "High" "IsMasterProtein" "Q6GMV2" "Histone-lysine N-trimethyltransferase SMYD5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2" "0.000" "False" "8.506" "5" "2" "2" "2" "418" "47.3" "5.05" "4.13" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "" "other molecular function" "Pf00856" "10322" "ENSG00000135632" "SMYD5" "D6W5H3; hsa:10322; Q13558; Q6GMV2" "" "Histone modifications" "1" "0" "0.957" "0.905" "0.896" "0.943" "0.952" "0.945" "0.932" "0.942" "0.938" "269.9" "258.4" "244.2" "241.8" "254.5" "257.0" "255.1" "251.5" "254.3" "253.1" "" "" "" "" "" "" "" "" "" "" "216.8" "186.5" "194.0" "162.0" "176.0" "192.8" "178.6" "183.6" "254.3" "205.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5480517122965498200" "False" "High" "IsMasterProtein" "P15735" "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Homo sapiens OX=9606 GN=PHKG2 PE=1 SV=1" "0.000" "False" "8.465" "7" "3" "3" "3" "406" "46.4" "6.38" "8.65" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069" "5261" "ENSG00000156873" "PHKG2" "A8K0C7; B4DEB7; E9PEU3; hsa:5261; P11800; P15735" "Glycogen breakdown (glycogenolysis)" "Ferroptosis; Glycogen synthesis and degradation; 1p36 copy number variation syndrome" "4" "0" "1.041" "0.920" "0.953" "0.946" "1.012" "0.987" "0.957" "1.003" "0.974" "120.8" "125.7" "111.2" "115.2" "114.3" "122.3" "119.3" "115.6" "121.2" "117.7" "" "" "" "" "" "" "" "" "" "" "97.0" "90.7" "88.3" "77.2" "79.1" "91.8" "83.5" "84.4" "121.2" "95.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5002411829564885472" "False" "High" "IsMasterProtein" "Q9GZQ8" "Microtubule-associated proteins 1A/1B light chain 3B OS=Homo sapiens OX=9606 GN=MAP1LC3B PE=1 SV=3" "0.000" "False" "8.456" "17" "2" "3" "2" "125" "14.7" "8.94" "6.17" "2" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02991" "81631" "ENSG00000140941" "MAP1LC3B" "hsa:81631; Q6NW02; Q9GZQ8" "KEAP1-NFE2L2 pathway; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; PINK1-PRKN Mediated Mitophagy; TBC/RABGAPs; Receptor Mediated Mitophagy; Pexophagy; SARS-CoV-2 modulates autophagy" "Ferroptosis; Autophagy; Opioid receptor pathways; Network map of SARS-CoV-2 signaling pathway; Clock-controlled autophagy in bone metabolism; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "16" "0" "1.009" "1.066" "0.927" "0.997" "1.111" "0.937" "0.974" "1.010" "1.064" "417.8" "421.7" "445.6" "387.4" "416.6" "464.1" "391.5" "406.8" "422.0" "444.7" "" "" "" "" "" "" "" "" "" "" "335.6" "304.3" "353.9" "259.5" "288.1" "348.2" "274.1" "297.1" "422.0" "361.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8593755170917475749" "False" "High" "IsMasterProtein" "P53803" "DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Homo sapiens OX=9606 GN=POLR2K PE=1 SV=1" "0.000" "False" "8.447" "41" "2" "2" "2" "58" "7.0" "9.06" "6.35" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf03604" "5440" "ENSG00000147669" "POLR2K" "hsa:5440; P53803; Q6IBD4" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "1.055" "1.158" "1.096" "0.975" "1.166" "0.960" "0.905" "1.029" "1.139" "204.8" "216.1" "237.2" "224.4" "199.6" "238.8" "196.5" "185.3" "210.8" "233.3" "" "" "" "" "" "" "" "" "" "" "164.5" "155.9" "188.4" "150.4" "138.1" "179.2" "137.6" "135.3" "210.8" "189.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845419377566949929" "False" "High" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "0.000" "False" "8.438" "12" "2" "4" "2" "147" "16.7" "7.80" "11.86" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "Proteasome degradation" "13" "0" "1.011" "0.951" "0.915" "1.002" "0.968" "0.987" "0.906" "0.901" "0.972" "420.3" "424.8" "399.5" "384.6" "420.9" "406.9" "414.9" "380.9" "378.7" "408.6" "" "" "" "" "" "" "" "" "" "" "337.6" "306.5" "317.3" "257.7" "291.1" "305.3" "290.5" "278.2" "378.7" "332.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5139154873677700372" "False" "High" "IsMasterProtein" "Q9H9V9" "2-oxoglutarate and iron-dependent oxygenase JMJD4 OS=Homo sapiens OX=9606 GN=JMJD4 PE=1 SV=3" "0.000" "False" "8.426" "6" "2" "2" "2" "417" "47.4" "5.54" "7.10" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "65094" "ENSG00000081692" "JMJD4" "A0A087WT84; hsa:65094; Q5TBZ1; Q5TBZ6; Q9H970; Q9H9V9" "Protein hydroxylation" "" "1" "0" "1.604" "1.016" "1.260" "1.055" "0.969" "1.118" "1.035" "0.918" "1.002" "18.0" "28.9" "18.3" "22.7" "19.0" "17.4" "20.1" "18.6" "16.5" "18.0" "" "" "" "" "" "" "" "" "" "" "14.5" "20.8" "14.5" "15.2" "13.1" "13.1" "14.1" "13.6" "16.5" "14.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390976206721305276" "False" "High" "IsMasterProtein" "Q9UJ98" "Cohesin subunit SA-3 OS=Homo sapiens OX=9606 GN=STAG3 PE=1 SV=2" "0.000" "False" "8.423" "2" "3" "4" "1" "1225" "138.9" "5.39" "12.35" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10734" "ENSG00000066923" "STAG3" "A6H8Z1; B4DZ10; D6W5U8; H7BYK9; hsa:10734; Q8NDP3; Q9UJ98" "Meiotic synapsis" "Cohesin complex - Cornelia de Lange syndrome; Primary ovarian insufficiency" "3" "0" "1.029" "0.926" "0.910" "0.812" "1.012" "0.918" "0.857" "1.002" "1.067" "117.1" "120.5" "108.5" "106.6" "95.1" "118.5" "107.5" "100.3" "117.3" "124.9" "" "" "" "" "" "" "" "" "" "" "94.0" "87.0" "86.1" "71.4" "65.7" "88.9" "75.3" "73.2" "117.3" "101.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4400970181844153843" "False" "High" "IsMasterProtein" "Q14689" "Disco-interacting protein 2 homolog A OS=Homo sapiens OX=9606 GN=DIP2A PE=1 SV=2" "0.000" "False" "8.417" "3" "3" "3" "2" "1571" "170.3" "8.03" "7.73" "3" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00501, Pf06464" "23181" "ENSG00000160305" "DIP2A" "A6P4T3; B4E0F0; E7EMA5; hsa:23181; Q14689; Q8IVA3; Q8N4S2; Q8TD89; Q96ML9" "" "Mesodermal commitment pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1947513766824077482" "False" "High" "IsMasterProtein" "Q9HCU9" "Breast cancer metastasis-suppressor 1 OS=Homo sapiens OX=9606 GN=BRMS1 PE=1 SV=1" "0.000" "False" "8.417" "8" "2" "3" "2" "246" "28.4" "4.74" "9.09" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf08598" "25855" "ENSG00000174744" "BRMS1" "hsa:25855; Q6IAI2; Q9HCU9" "Potential therapeutics for SARS; HDACs deacetylate histones" "" "2" "0" "1.030" "0.914" "0.808" "0.819" "0.911" "0.915" "0.781" "0.939" "0.987" "40.1" "41.3" "36.7" "32.4" "32.9" "36.5" "36.7" "31.3" "37.7" "39.6" "" "" "" "" "" "" "" "" "" "" "32.2" "29.8" "29.1" "21.7" "22.7" "27.4" "25.7" "22.9" "37.7" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-998134309870178967" "False" "High" "IsMasterProtein" "P47974" "mRNA decay activator protein ZFP36L2 OS=Homo sapiens OX=9606 GN=ZFP36L2 PE=1 SV=3" "0.000" "False" "8.415" "3" "1" "1" "1" "494" "51.0" "8.16" "5.13" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "678" "ENSG00000152518" "ZFP36L2" "hsa:678; P47974; Q53TB4; Q9BSJ3" "M-decay: degradation of maternal mRNAs by maternally stored factors" "Pre-implantation embryo; TYROBP causal network in microglia" "3" "0" "1.007" "1.099" "1.064" "1.070" "0.931" "0.990" "0.981" "1.115" "1.001" "70.6" "71.1" "77.6" "75.2" "75.6" "65.8" "69.9" "69.3" "78.8" "70.7" "" "" "" "" "" "" "" "" "" "" "56.7" "51.3" "61.7" "50.4" "52.3" "49.3" "49.0" "50.6" "78.8" "57.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1765905761415043140" "False" "High" "IsMasterProtein" "Q96PY6" "Serine/threonine-protein kinase Nek1 OS=Homo sapiens OX=9606 GN=NEK1 PE=1 SV=2" "0.000" "False" "8.412" "3" "3" "3" "3" "1258" "142.7" "5.94" "4.16" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "4750" "ENSG00000137601" "NEK1" "G5E9Z3; hsa:4750; Q05DG5; Q14CB7; Q5H9T1; Q6PIB8; Q96PY6; Q96SS2; Q9H6P7; Q9Y594" "" "Ciliopathies; Bardet-Biedl syndrome" "2" "0" "1.084" "1.034" "1.067" "1.136" "0.929" "1.058" "1.052" "0.973" "0.965" "250.5" "271.6" "258.9" "267.3" "284.5" "232.6" "265.0" "263.4" "243.7" "241.7" "" "" "" "" "" "" "" "" "" "" "201.2" "196.0" "205.7" "179.1" "196.8" "174.6" "185.5" "192.4" "243.7" "196.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8612473288009054962" "False" "High" "IsMasterProtein" "Q16626" "Male-enhanced antigen 1 OS=Homo sapiens OX=9606 GN=MEA1 PE=1 SV=2" "0.000" "False" "8.406" "9" "1" "2" "1" "185" "19.9" "4.22" "6.73" "1" "developmental processes;other biological processes" "other cell component" "" "Pf06910" "4201" "ENSG00000124733" "MEA1" "hsa:4201; Q16626; Q5TC36; Q9BV01" "" "" "0" "0" "0.934" "0.687" "0.920" "1.008" "0.838" "1.145" "1.110" "0.903" "0.990" "72.5" "67.7" "49.8" "66.6" "73.0" "60.7" "83.0" "80.4" "65.4" "71.7" "" "" "" "" "" "" "" "" "" "" "58.2" "48.8" "39.5" "44.6" "50.5" "45.5" "58.1" "58.7" "65.4" "58.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9152525013652249776" "False" "High" "IsMasterProtein" "Q9H999" "Pantothenate kinase 3 OS=Homo sapiens OX=9606 GN=PANK3 PE=1 SV=1" "0.000" "False" "8.339" "7" "3" "3" "1" "370" "41.1" "6.55" "8.21" "3" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf03630" "79646" "ENSG00000120137" "PANK3" "D3DQL1; hsa:79646; Q53FJ9; Q7RTX4; Q9H999" "Coenzyme A biosynthesis" "" "1" "0" "1.244" "1.137" "1.013" "1.192" "1.054" "1.241" "1.297" "1.009" "1.251" "48.7" "60.6" "55.3" "49.3" "58.0" "51.3" "60.4" "63.2" "49.1" "60.9" "" "" "" "" "" "" "" "" "" "" "39.1" "43.7" "44.0" "33.1" "40.1" "38.5" "42.3" "46.1" "49.1" "49.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5511043592146931857" "False" "High" "IsMasterProtein" "Q9BSB4" "Autophagy-related protein 101 OS=Homo sapiens OX=9606 GN=ATG101 PE=1 SV=1" "0.000" "False" "8.327" "21" "4" "4" "4" "218" "25.0" "6.15" "5.22" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf07855" "60673" "ENSG00000123395" "ATG101" "hsa:60673; Q9BSB4; Q9HAE2; Q9HBN1" "Macroautophagy" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "8" "0" "1.002" "0.958" "1.054" "1.196" "1.024" "1.017" "1.098" "1.057" "1.078" "195.1" "195.5" "186.9" "205.7" "233.5" "199.7" "198.4" "214.3" "206.2" "210.4" "" "" "" "" "" "" "" "" "" "" "156.7" "141.1" "148.4" "137.8" "161.5" "149.9" "138.9" "156.5" "206.2" "171.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2679816748943853066" "False" "High" "IsMasterProtein" "Q9ULH7" "Myocardin-related transcription factor B OS=Homo sapiens OX=9606 GN=MRTFB PE=1 SV=3" "0.000" "False" "8.309" "2" "3" "3" "2" "1088" "118.1" "6.28" "8.92" "3" "other biological processes" "nucleus" "other molecular function" "Pf02037, Pf02755" "57496" "ENSG00000186260" "MRTFB" "A6ND53; B4DGT8; hsa:57496; Q68CT1; Q6UB16; Q86WW2; Q8N226; Q9ULH7" "" "" "0" "0" "1.018" "1.002" "1.090" "1.104" "0.995" "0.995" "1.002" "1.045" "1.049" "195.5" "199.1" "196.0" "213.1" "215.9" "194.5" "194.6" "195.8" "204.4" "205.1" "" "" "" "" "" "" "" "" "" "" "157.0" "143.7" "155.7" "142.8" "149.3" "145.9" "136.3" "143.0" "204.4" "166.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2213964009562645664" "False" "High" "IsMasterProtein" "Q9Y221" "60S ribosome subunit biogenesis protein NIP7 homolog OS=Homo sapiens OX=9606 GN=NIP7 PE=1 SV=1" "0.000" "False" "8.303" "14" "3" "4" "3" "180" "20.4" "8.51" "13.04" "3" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf03657, Pf17833" "51388" "ENSG00000132603" "NIP7" "B2RD04; hsa:51388; Q9NZZ0; Q9Y221" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.978" "1.205" "1.032" "1.141" "1.242" "1.131" "0.971" "0.903" "1.020" "467.7" "457.4" "563.6" "482.9" "533.7" "580.9" "528.7" "454.0" "422.2" "477.2" "" "" "" "" "" "" "" "" "" "" "375.6" "330.0" "447.7" "323.5" "369.1" "435.8" "370.2" "331.5" "422.2" "388.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1389983804562693885" "False" "High" "IsMasterProtein" "A2RUC4" "tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1" "0.000" "False" "8.293" "10" "4" "4" "4" "315" "36.5" "7.55" "6.89" "4" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf13621" "129450" "ENSG00000162971" "TYW5" "A2RUC4; B2RNE3; hsa:129450; Q8N1R2" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "0.984" "0.907" "1.012" "1.066" "0.958" "1.024" "0.943" "0.988" "1.003" "298.4" "293.7" "270.7" "301.9" "318.1" "286.0" "305.6" "281.5" "294.8" "299.3" "" "" "" "" "" "" "" "" "" "" "239.7" "212.0" "215.0" "202.3" "220.0" "214.5" "214.0" "205.6" "294.8" "243.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7038810457230990351" "False" "High" "IsMasterProtein" "Q8NB15" "Zinc finger protein 511 OS=Homo sapiens OX=9606 GN=ZNF511 PE=1 SV=2" "0.000" "False" "8.291" "10" "2" "3" "2" "252" "28.2" "7.66" "10.31" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "118472" "ENSG00000198546" "ZNF511" "A8K8L5; hsa:118472; Q8NB15; Q8WUP1; Q96BV2" "" "" "0" "0" "0.985" "0.939" "1.081" "0.983" "1.169" "0.833" "0.891" "1.121" "0.842" "20.1" "19.8" "18.8" "21.7" "19.7" "23.4" "16.7" "17.9" "22.5" "16.9" "" "" "" "" "" "" "" "" "" "" "16.1" "14.3" "15.0" "14.5" "13.6" "17.6" "11.7" "13.0" "22.5" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490540137738339289" "False" "High" "IsMasterProtein" "Q9UJA3" "DNA helicase MCM8 OS=Homo sapiens OX=9606 GN=MCM8 PE=1 SV=2" "0.000" "False" "8.288" "3" "2" "3" "1" "840" "93.6" "7.75" "8.29" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf17207, Pf17855" "84515" "ENSG00000125885" "MCM8" "B2RBG7; D3DW08; E7EQU7; hsa:84515; Q495R4; Q495R6; Q495R7; Q86US4; Q969I5; Q9UJA3" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex; Unwinding of DNA" "Ciliary landscape; Primary ovarian insufficiency" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137726994373398706" "False" "High" "IsMasterProtein" "O14607" "Histone demethylase UTY OS=Homo sapiens OX=9606 GN=UTY PE=1 SV=2" "0.000" "False" "8.287" "2" "4" "6" "1" "1347" "149.5" "7.75" "11.43" "4" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02373, Pf13181, Pf21322, Pf21326" "7404" "ENSG00000183878" "UTY" "A8K9Z3; E1U199; E1U1A0; F5H4V7; F8W8R7; hsa:7404; O14607; O14608" "HDMs demethylate histones" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3774842769131475239" "False" "High" "IsMasterProtein" "Q9Y2R5" "Small ribosomal subunit protein uS17m OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1" "0.000" "False" "8.284" "22" "3" "3" "3" "130" "14.5" "9.85" "8.08" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf00366" "51373" "ENSG00000239789" "MRPS17" "hsa:51373; Q86X15; Q9Y2R5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.092" "1.026" "1.141" "0.988" "1.010" "1.109" "1.024" "0.971" "1.016" "159.0" "173.7" "163.1" "181.4" "157.1" "160.6" "176.4" "162.8" "154.5" "161.6" "" "" "" "" "" "" "" "" "" "" "127.7" "125.4" "129.6" "121.6" "108.6" "120.5" "123.5" "118.9" "154.5" "131.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258302069466510735" "False" "High" "IsMasterProtein" "P56279" "T-cell leukemia/lymphoma protein 1A OS=Homo sapiens OX=9606 GN=TCL1A PE=1 SV=1" "0.000" "False" "8.266" "19" "2" "3" "2" "114" "13.5" "5.11" "9.24" "2" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01840" "8115" "ENSG00000100721" "TCL1A" "hsa:8115; P56279; Q6IBK7" "" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "2" "0" "1.158" "1.363" "1.154" "1.086" "1.305" "1.114" "1.120" "1.183" "0.957" "80.2" "92.8" "109.2" "92.5" "87.0" "104.7" "89.3" "89.8" "94.8" "76.7" "" "" "" "" "" "" "" "" "" "" "64.4" "67.0" "86.8" "62.0" "60.2" "78.5" "62.5" "65.6" "94.8" "62.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6321776130452368548" "False" "High" "IsMasterProtein" "Q9H7Z6" "Histone acetyltransferase KAT8 OS=Homo sapiens OX=9606 GN=KAT8 PE=1 SV=2" "0.000" "False" "8.262" "4" "2" "2" "2" "458" "52.4" "8.27" "7.85" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "84148" "ENSG00000103510" "KAT8" "A8K4Z1; G5E9P2; hsa:84148; Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9H7Z6; Q9HAC5; Q9NR35" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "" "2" "0" "1.069" "1.062" "1.060" "1.093" "1.075" "1.001" "1.039" "1.025" "1.054" "234.3" "250.5" "248.8" "248.4" "256.1" "252.0" "234.6" "243.4" "240.3" "247.0" "" "" "" "" "" "" "" "" "" "" "188.2" "180.7" "197.7" "166.4" "177.1" "189.1" "164.3" "177.8" "240.3" "200.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6162368025994279371" "False" "High" "IsMasterProtein" "Q13395" "Probable methyltransferase TARBP1 OS=Homo sapiens OX=9606 GN=TARBP1 PE=1 SV=1" "0.000" "False" "8.251" "1" "2" "2" "2" "1621" "181.6" "7.05" "7.01" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00588" "6894" "ENSG00000059588" "TARBP1" "hsa:6894; Q13395; Q9H581" "" "" "0" "0" "1.471" "1.244" "1.208" "1.157" "1.206" "1.220" "1.077" "1.234" "1.175" "195.9" "288.2" "243.7" "236.7" "226.6" "236.2" "239.1" "211.0" "241.7" "230.2" "" "" "" "" "" "" "" "" "" "" "157.4" "208.0" "193.6" "158.6" "156.7" "177.2" "167.4" "154.1" "241.7" "187.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714422319878504399" "False" "High" "IsMasterProtein" "O95391" "Pre-mRNA-splicing factor SLU7 OS=Homo sapiens OX=9606 GN=SLU7 PE=1 SV=2" "0.000" "False" "8.248" "4" "2" "2" "2" "586" "68.3" "7.14" "6.24" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11708" "10569" "ENSG00000164609" "SLU7" "D3DQK2; hsa:10569; O95391; Q3LUJ0; Q3LUJ1; Q6RXQ5; Q96FM9" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "4" "0" "0.989" "0.838" "1.171" "1.233" "0.993" "1.145" "1.211" "1.149" "1.206" "106.4" "105.2" "89.2" "124.6" "131.3" "105.7" "121.9" "128.9" "122.3" "128.3" "" "" "" "" "" "" "" "" "" "" "85.5" "75.9" "70.9" "83.5" "90.8" "79.3" "85.3" "94.1" "122.3" "104.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5113146668834443448" "False" "High" "IsMasterProtein" "Q9NRG4" "N-lysine methyltransferase SMYD2 OS=Homo sapiens OX=9606 GN=SMYD2 PE=1 SV=2" "0.000" "False" "8.238" "6" "2" "2" "2" "433" "49.7" "6.71" "3.83" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00856, Pf01753" "56950" "ENSG00000143499" "SMYD2" "B2R9P9; hsa:56950; I6L9H7; Q4V765; Q5VSH9; Q96AI4; Q9NRG4" "PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation" "Histone modifications" "3" "0" "0.974" "0.996" "1.055" "1.002" "0.930" "0.892" "0.904" "0.971" "0.989" "127.8" "124.4" "127.2" "134.8" "128.0" "118.8" "114.0" "115.5" "124.1" "126.4" "" "" "" "" "" "" "" "" "" "" "102.6" "89.8" "101.1" "90.3" "88.5" "89.1" "79.8" "84.4" "124.1" "102.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1343964700997120443" "False" "High" "IsMasterProtein" "O94830" "Phospholipase DDHD2 OS=Homo sapiens OX=9606 GN=DDHD2 PE=1 SV=2" "0.000" "False" "8.236" "5" "3" "3" "3" "711" "81.0" "5.39" "7.61" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "23259" "ENSG00000085788" "DDHD2" "B3KWV2; B3KXB5; hsa:23259; O94830; Q9H8X7" "Synthesis of PA" "" "1" "0" "1.056" "0.986" "1.215" "1.183" "1.117" "1.022" "1.141" "1.091" "0.967" "97.1" "102.6" "95.7" "118.0" "114.9" "108.5" "99.3" "110.8" "105.9" "94.0" "" "" "" "" "" "" "" "" "" "" "78.0" "74.0" "76.1" "79.1" "79.5" "81.4" "69.5" "81.0" "105.9" "76.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286277691384661774" "False" "High" "IsMasterProtein" "Q6P1X5" "Transcription initiation factor TFIID subunit 2 OS=Homo sapiens OX=9606 GN=TAF2 PE=1 SV=3" "0.000" "False" "8.235" "3" "4" "4" "4" "1199" "136.9" "8.19" "11.05" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "6873" "ENSG00000064313" "TAF2" "B2RE82; hsa:6873; O43487; O43604; O60668; Q6P1X5; Q86WW7; Q8IWK4" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "9" "0" "1.131" "1.020" "0.956" "0.996" "1.176" "1.010" "0.955" "1.212" "1.037" "102.5" "116.0" "104.6" "98.1" "102.1" "120.6" "103.6" "98.0" "124.2" "106.3" "" "" "" "" "" "" "" "" "" "" "82.4" "83.7" "83.1" "65.7" "70.6" "90.5" "72.6" "71.6" "124.2" "86.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697873925504819237" "False" "High" "IsMasterProtein" "P50053" "Ketohexokinase OS=Homo sapiens OX=9606 GN=KHK PE=1 SV=2" "0.000" "False" "8.225" "8" "3" "3" "3" "298" "32.5" "6.32" "10.20" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00294" "3795" "ENSG00000138030" "KHK" "hsa:3795; P50053; Q6IBK2; Q99532; Q9BRJ3; Q9UMN1" "Fructose catabolism; Essential fructosuria" "Disorders of fructose metabolism; Polyol pathway" "4" "0" "1.039" "0.765" "0.851" "1.113" "1.062" "0.978" "1.085" "1.056" "1.001" "41.1" "42.7" "31.4" "34.9" "45.7" "43.6" "40.2" "44.6" "43.4" "41.1" "" "" "" "" "" "" "" "" "" "" "33.0" "30.8" "25.0" "23.4" "31.6" "32.7" "28.1" "32.5" "43.4" "33.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5380197694992633096" "False" "High" "IsMasterProtein" "Q9BWG4" "Single-stranded DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=SSBP4 PE=1 SV=1" "0.000" "False" "8.218" "5" "2" "2" "1" "385" "39.4" "6.80" "6.85" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04503" "170463" "ENSG00000130511" "SSBP4" "hsa:170463; Q9BWG4; Q9BWW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4234172936871541887" "False" "High" "IsMasterProtein" "Q9HA65" "TBC1 domain family member 17 OS=Homo sapiens OX=9606 GN=TBC1D17 PE=1 SV=3" "0.000" "False" "8.212" "4" "3" "3" "3" "648" "72.6" "5.21" "6.37" "3" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00566, Pf12068" "79735" "ENSG00000104946" "TBC1D17" "B4DT12; B9A6L8; F5H1W7; hsa:79735; Q9HA65" "TBC/RABGAPs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952210186294942098" "False" "High" "IsMasterProtein" "O15315" "DNA repair protein RAD51 homolog 2 OS=Homo sapiens OX=9606 GN=RAD51B PE=1 SV=2" "0.000" "False" "8.211" "5" "2" "2" "2" "384" "42.2" "5.69" "5.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5890" "ENSG00000182185" "RAD51B" "hsa:5890; O15315; O60914; O75210; Q3Y4F8; Q6FHX8; Q86SY3; Q86SY4; Q86TR0; Q86U92; Q86U93; Q86U94; Q8N6H4; Q9UPL5" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7020233943661812607" "False" "High" "IsMasterProtein" "Q9NUJ3" "T-complex protein 11-like protein 1 OS=Homo sapiens OX=9606 GN=TCP11L1 PE=1 SV=1" "0.000" "False" "8.199" "4" "2" "2" "2" "509" "57.0" "5.59" "6.54" "2" "signal transduction" "cytoskeleton" "" "Pf05794" "55346" "ENSG00000176148" "TCP11L1" "D3DR01; hsa:55346; Q8IVX4; Q9NUJ3" "" "" "0" "0" "1.135" "0.880" "1.081" "1.134" "0.911" "1.127" "0.899" "0.857" "0.988" "70.8" "80.4" "62.3" "76.6" "80.3" "64.5" "79.9" "63.6" "60.7" "70.0" "" "" "" "" "" "" "" "" "" "" "56.9" "58.0" "49.5" "51.3" "55.5" "48.4" "55.9" "46.5" "60.7" "56.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4879216047058048587" "False" "High" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "0.000" "False" "8.199" "16" "2" "2" "2" "110" "11.3" "6.54" "5.80" "2" "protein metabolism;stress response;transport" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "Antimicrobial peptides" "" "1" "0" "0.815" "0.862" "1.112" "2.396" "2.001" "2.662" "1.336" "4.794" "1.742" "154.3" "125.8" "133.0" "171.7" "369.8" "308.8" "410.9" "206.2" "739.8" "268.8" "" "" "" "" "" "" "" "" "" "" "124.0" "90.8" "105.7" "115.0" "255.8" "231.7" "287.7" "150.6" "739.8" "218.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1532626323839813541" "False" "High" "IsMasterProtein" "Q99622" "Protein C10 OS=Homo sapiens OX=9606 GN=C12orf57 PE=1 SV=1" "0.000" "False" "8.197" "22" "2" "2" "2" "126" "13.2" "5.14" "6.51" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf14974" "113246" "ENSG00000111678" "C12orf57" "B2R4Q6; hsa:113246; Q99622" "" "" "0" "0" "1.157" "0.949" "1.003" "1.003" "1.045" "1.099" "1.030" "1.008" "1.076" "223.7" "258.7" "212.2" "224.3" "224.3" "233.8" "245.8" "230.5" "225.5" "240.7" "" "" "" "" "" "" "" "" "" "" "179.6" "186.7" "168.5" "150.3" "155.1" "175.4" "172.1" "168.3" "225.5" "195.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3120640487531832187" "False" "High" "IsMasterProtein" "Q9BTT4" "Mediator of RNA polymerase II transcription subunit 10 OS=Homo sapiens OX=9606 GN=MED10 PE=1 SV=1" "0.000" "False" "8.195" "14" "2" "2" "2" "135" "15.7" "6.19" "6.69" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09748" "84246" "ENSG00000133398; ENSG00000291745" "MED10" "C6G491; hsa:84246; Q9BTT4" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4102789936639364292" "False" "High" "IsMasterProtein" "Q9NPP4" "NLR family CARD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=NLRC4 PE=1 SV=2" "0.000" "False" "8.193" "2" "2" "2" "2" "1024" "116.1" "6.77" "5.75" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf05729, Pf17889" "58484" "ENSG00000091106" "NLRC4" "A8K9F8; B2RBQ3; B3KTF0; D6W580; hsa:58484; Q96J81; Q96J82; Q96J83; Q9NPP4" "TP53 Regulates Transcription of Caspase Activators and Caspases; The IPAF inflammasome" "Nucleotide-binding oligomerization domain (NOD) pathway" "3" "0" "0.977" "0.891" "0.950" "0.890" "0.997" "0.909" "0.863" "1.009" "0.885" "82.4" "80.5" "73.4" "78.3" "73.4" "82.2" "74.9" "71.1" "83.2" "72.9" "" "" "" "" "" "" "" "" "" "" "66.2" "58.1" "58.3" "52.5" "50.7" "61.7" "52.5" "51.9" "83.2" "59.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3461094019956647414" "False" "High" "IsMasterProtein" "Q96KQ7" "Histone-lysine N-methyltransferase EHMT2 OS=Homo sapiens OX=9606 GN=EHMT2 PE=1 SV=3" "0.000" "False" "8.183" "2" "3" "3" "3" "1210" "132.3" "5.45" "6.50" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00856, Pf05033, Pf21533" "10919" "ENSG00000204371; ENSG00000206376; ENSG00000227333; ENSG00000232045; ENSG00000236759; ENSG00000238134" "EHMT2" "B0UZY2; hsa:10919; Q14349; Q5JP83; Q5JQ92; Q5JQA1; Q5JQG3; Q6PK06; Q96KQ7; Q96MH5; Q96QD0; Q9UQL8; Q9Y331" "Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Transcriptional Regulation by VENTX; Regulation of TP53 Activity through Methylation; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Histone modifications; Ethanol effects on histone modifications; MTHFR deficiency" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6379952211340011163" "False" "High" "IsMasterProtein" "Q96CJ1" "ELL-associated factor 2 OS=Homo sapiens OX=9606 GN=EAF2 PE=1 SV=1" "0.000" "False" "8.182" "20" "4" "4" "2" "260" "28.8" "5.17" "8.30" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf09816" "55840" "ENSG00000145088" "EAF2" "hsa:55840; Q96CJ1; Q9NZ82" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "1" "1.047" "1.156" "1.162" "1.308" "1.205" "1.233" "1.404" "1.467" "1.320" "174.1" "182.2" "201.2" "202.4" "227.8" "209.8" "214.6" "244.5" "255.3" "229.8" "" "" "" "" "" "" "" "" "" "" "139.8" "131.5" "159.8" "135.6" "157.5" "157.4" "150.3" "178.6" "255.3" "186.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494838164348438910" "False" "High" "IsMasterProtein" "Q08117" "TLE family member 5 OS=Homo sapiens OX=9606 GN=TLE5 PE=1 SV=4" "0.000" "False" "8.177" "11" "2" "2" "2" "197" "22.0" "6.37" "7.46" "2" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf03920" "166" "ENSG00000104964" "TLE5" "B2RBL0; hsa:166; Q08117; Q12808; Q14CJ1; Q96TG9; Q9UDY9" "Repression of WNT target genes" "Androgen receptor signaling pathway; Ectoderm differentiation" "3" "0" "1.090" "1.086" "1.101" "1.214" "1.005" "1.102" "1.220" "1.064" "1.035" "114.3" "124.6" "124.2" "125.8" "138.8" "114.9" "126.0" "139.5" "121.7" "118.3" "" "" "" "" "" "" "" "" "" "" "91.8" "89.9" "98.7" "84.3" "96.0" "86.2" "88.2" "101.9" "121.7" "96.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4999747194437679436" "False" "High" "IsMasterProtein" "Q969M7" "NEDD8-conjugating enzyme UBE2F OS=Homo sapiens OX=9606 GN=UBE2F PE=1 SV=1" "0.000" "False" "8.173" "17" "3" "3" "3" "185" "21.1" "6.79" "6.54" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "140739" "ENSG00000184182" "UBE2F" "A8K1Z8; B4DDT9; B4DFI1; B4DMK3; B4DZU2; B8ZZG2; C9J212; H9KVB9; Q969M7" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2q37 copy number variation syndrome" "3" "0" "1.031" "1.015" "1.097" "1.055" "1.028" "1.036" "0.979" "1.097" "1.020" "223.6" "230.6" "227.0" "245.3" "235.9" "229.8" "231.7" "218.8" "245.2" "228.0" "" "" "" "" "" "" "" "" "" "" "179.6" "166.4" "180.3" "164.3" "163.1" "172.4" "162.2" "159.8" "245.2" "185.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8337602067628073965" "False" "High" "IsMasterProtein" "O00159" "Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4" "0.000" "False" "8.150" "2" "2" "2" "2" "1063" "121.6" "9.41" "6.71" "2" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4641" "ENSG00000197879" "MYO1C" "hsa:4641; O00159; Q4LE56; Q6NVJ7; Q86Y95" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane" "VEGFA-VEGFR2 signaling; Insulin signaling; 10q11.21q11.23 copy number variation syndrome" "8" "0" "1.043" "1.128" "1.237" "1.089" "0.996" "1.127" "1.127" "1.066" "1.161" "236.0" "246.3" "266.2" "291.9" "257.1" "235.0" "266.0" "266.0" "251.5" "274.0" "" "" "" "" "" "" "" "" "" "" "189.6" "177.7" "211.4" "195.6" "177.8" "176.3" "186.3" "194.3" "251.5" "222.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1617680117434618445" "False" "High" "IsMasterProtein" "P42696" "RNA-binding protein 34 OS=Homo sapiens OX=9606 GN=RBM34 PE=1 SV=2" "0.000" "False" "8.144" "8" "3" "3" "3" "430" "48.5" "10.11" "5.29" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "23029" "ENSG00000188739" "RBM34" "A8K8J7; hsa:23029; P42696; Q8N2Z8; Q9H5A1" "" "" "0" "0" "0.890" "1.097" "0.805" "0.706" "0.963" "1.101" "0.996" "0.890" "1.034" "18.2" "16.2" "19.9" "14.6" "12.8" "17.5" "20.0" "18.1" "16.2" "18.8" "" "" "" "" "" "" "" "" "" "" "14.6" "11.7" "15.8" "9.8" "8.9" "13.1" "14.0" "13.2" "16.2" "15.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-942541566262454804" "False" "High" "IsMasterProtein" "Q9BRQ0" "Pygopus homolog 2 OS=Homo sapiens OX=9606 GN=PYGO2 PE=1 SV=2" "0.000" "False" "8.127" "4" "1" "1" "1" "406" "41.2" "7.28" "4.67" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf00628" "90780" "ENSG00000163348" "PYGO2" "hsa:90780; Q8WYZ4; Q96CY2; Q9BRQ0" "Deactivation of the beta-catenin transactivating complex; Formation of the beta-catenin:TCF transactivating complex" "1q21.1 copy number variation syndrome" "3" "0" "1.106" "1.133" "1.303" "1.063" "1.150" "1.064" "1.166" "1.124" "1.175" "51.7" "57.2" "58.6" "67.4" "55.0" "59.5" "55.1" "60.3" "58.2" "60.8" "" "" "" "" "" "" "" "" "" "" "41.5" "41.3" "46.5" "45.2" "38.0" "44.6" "38.5" "44.1" "58.2" "49.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6009114136998479207" "False" "High" "IsMasterProtein" "Q9GZR1" "Sentrin-specific protease 6 OS=Homo sapiens OX=9606 GN=SENP6 PE=1 SV=2" "0.000" "False" "8.108" "2" "2" "2" "2" "1112" "126.1" "6.73" "5.27" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02902" "26054" "ENSG00000112701" "SENP6" "A6NNY9; hsa:26054; O94891; Q5VUL3; Q5VUL4; Q8TBY4; Q9GZR1; Q9UJV5" "" "" "0" "0" "1.044" "0.951" "1.014" "0.896" "1.003" "0.994" "0.930" "0.961" "1.119" "70.4" "73.5" "67.0" "71.4" "63.1" "70.6" "70.0" "65.5" "67.6" "78.8" "" "" "" "" "" "" "" "" "" "" "56.6" "53.0" "53.2" "47.9" "43.7" "53.0" "49.0" "47.8" "67.6" "64.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2353077507000470893" "False" "High" "IsMasterProtein" "Q6PI98" "INO80 complex subunit C OS=Homo sapiens OX=9606 GN=INO80C PE=1 SV=1" "0.000" "False" "8.108" "9" "1" "1" "1" "192" "20.6" "10.02" "4.25" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf08265" "125476" "ENSG00000153391" "INO80C" "B4DUI4; E9PCS7; hsa:125476; Q6PI98; Q86WR1; Q8N994" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "0.912" "1.005" "0.915" "0.888" "0.930" "0.826" "0.891" "1.005" "1.075" "118.8" "108.4" "119.3" "108.8" "105.5" "110.5" "98.1" "105.9" "119.4" "127.7" "" "" "" "" "" "" "" "" "" "" "95.4" "78.2" "94.8" "72.9" "73.0" "82.9" "68.7" "77.3" "119.4" "103.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-334461821702611292" "False" "High" "IsMasterProtein" "Q6DCA0" "AMMECR1-like protein OS=Homo sapiens OX=9606 GN=AMMECR1L PE=1 SV=1" "0.000" "False" "8.104" "6" "2" "2" "2" "310" "34.5" "8.98" "8.54" "2" "" "nucleus" "" "Pf01871" "83607" "ENSG00000144233" "AMMECR1L" "B4E276; hsa:83607; Q6DCA0" "" "" "0" "0" "1.074" "1.058" "1.059" "1.050" "1.087" "0.991" "0.977" "1.084" "1.063" "362.6" "389.6" "383.7" "384.0" "380.6" "394.2" "359.4" "354.3" "393.2" "385.6" "" "" "" "" "" "" "" "" "" "" "291.3" "281.1" "304.8" "257.3" "263.2" "295.8" "251.6" "258.7" "393.2" "313.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "729714306402912246" "False" "High" "IsMasterProtein" "Q15628" "Tumor necrosis factor receptor type 1-associated DEATH domain protein OS=Homo sapiens OX=9606 GN=TRADD PE=1 SV=2" "0.000" "False" "8.102" "11" "3" "3" "3" "312" "34.2" "6.27" "7.43" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf09034" "8717" "ENSG00000102871" "TRADD" "B2RDS3; B3KQZ9; hsa:8717; Q15628; Q52NZ1" "Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Defective RIPK1-mediated regulated necrosis" "TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4583007171926660229" "False" "High" "IsMasterProtein" "Q9H1I8" "Activating signal cointegrator 1 complex subunit 2 OS=Homo sapiens OX=9606 GN=ASCC2 PE=1 SV=3" "0.000" "False" "8.095" "3" "2" "2" "2" "757" "86.3" "5.16" "6.65" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf02845" "84164" "ENSG00000100325" "ASCC2" "B7Z8E0; F5H6J9; hsa:84164; Q4TT54; Q8TAZ0; Q9H1I8; Q9H711; Q9H9D6" "ALKBH3 mediated reversal of alkylation damage" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8410241835469765050" "False" "High" "IsMasterProtein" "Q9Y2G2" "Caspase recruitment domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CARD8 PE=1 SV=2" "0.000" "False" "8.094" "3" "2" "2" "2" "537" "60.6" "4.84" "7.11" "2" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf13553" "22900" "ENSG00000105483" "CARD8" "B5KVR6; B5KVR8; B7Z496; B7Z4A2; E5RFV9; E9PEM7; G3XAM9; hsa:22900; Q6PGP8; Q96P82; Q9Y2G2" "Regulation of the apoptosome activity" "Nucleotide-binding oligomerization domain (NOD) pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2978485946285835937" "False" "High" "IsMasterProtein" "Q8NHH9" "Atlastin-2 OS=Homo sapiens OX=9606 GN=ATL2 PE=1 SV=2" "0.000" "False" "8.091" "3" "2" "3" "2" "583" "66.2" "5.48" "6.63" "2" "cell organization and biogenesis" "other membranes;ER/Golgi" "other molecular function" "Pf02263, Pf02841" "64225" "ENSG00000119787" "ATL2" "B7Z1X2; B7Z7X8; hsa:64225; Q4ZG30; Q7Z630; Q8NHH8; Q8NHH9; Q9H5M7" "" "" "0" "0" "1.107" "1.024" "1.270" "1.182" "0.957" "1.068" "1.094" "1.136" "1.156" "106.0" "117.4" "108.5" "134.6" "125.4" "101.4" "113.2" "115.9" "120.4" "122.6" "" "" "" "" "" "" "" "" "" "" "85.2" "84.7" "86.2" "90.2" "86.7" "76.1" "79.3" "84.7" "120.4" "99.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3169439293893359874" "False" "High" "IsMasterProtein" "Q96CN5" "Leucine-rich repeat-containing protein 45 OS=Homo sapiens OX=9606 GN=LRRC45 PE=1 SV=1" "0.000" "False" "8.089" "3" "2" "2" "2" "670" "75.9" "6.23" "3.39" "2" "" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "" "Pf13516" "201255" "ENSG00000169683" "LRRC45" "hsa:201255; Q96CN5" "" "" "0" "0" "0.908" "0.859" "1.003" "0.994" "1.007" "1.041" "0.986" "1.032" "0.864" "107.6" "97.8" "92.5" "107.9" "106.9" "108.3" "112.0" "106.1" "111.0" "93.0" "" "" "" "" "" "" "" "" "" "" "86.4" "70.5" "73.5" "72.3" "74.0" "81.3" "78.4" "77.5" "111.0" "75.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1171297253546326275" "False" "High" "IsMasterProtein" "Q6AI08" "HEAT repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=HEATR6 PE=1 SV=1" "0.000" "False" "8.068" "1" "1" "1" "1" "1181" "128.7" "7.03" "4.06" "1" "" "" "" "Pf13251" "63897" "ENSG00000068097" "HEATR6" "B3KXP3; hsa:63897; Q6AI08; Q6MZX1; Q6MZY2; Q8TDM9; Q9H6B3; Q9H6M7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696589814023666564" "False" "High" "IsMasterProtein" "Q13503" "Mediator of RNA polymerase II transcription subunit 21 OS=Homo sapiens OX=9606 GN=MED21 PE=1 SV=1" "0.000" "False" "8.067" "13" "1" "2" "1" "144" "15.6" "4.45" "10.40" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11221" "9412" "ENSG00000152944" "MED21" "B2R4I3; hsa:9412; Q13503; Q6IB05; Q92811" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "0.871" "0.959" "0.927" "0.958" "0.997" "1.049" "0.857" "1.044" "0.908" "114.2" "99.5" "109.5" "105.8" "109.4" "113.8" "119.8" "97.9" "119.2" "103.7" "" "" "" "" "" "" "" "" "" "" "91.7" "71.8" "87.0" "70.9" "75.7" "85.4" "83.9" "71.5" "119.2" "84.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256301948778102802" "False" "High" "IsMasterProtein" "Q8NCE0" "tRNA-splicing endonuclease subunit Sen2 OS=Homo sapiens OX=9606 GN=TSEN2 PE=1 SV=2" "0.000" "False" "8.067" "6" "3" "3" "3" "465" "53.2" "7.85" "7.78" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01974, Pf02778" "80746" "ENSG00000154743" "TSEN2" "B7Z6K1; C9IZI7; G5E9Q3; hsa:80746; Q8NCE0; Q8WTW7; Q9BPU7" "tRNA processing in the nucleus" "" "1" "0" "1.072" "0.924" "1.166" "1.066" "1.036" "1.079" "1.018" "0.902" "1.074" "121.3" "130.0" "112.2" "141.5" "129.4" "125.7" "130.9" "123.5" "109.5" "130.3" "" "" "" "" "" "" "" "" "" "" "97.5" "93.8" "89.1" "94.8" "89.5" "94.3" "91.7" "90.2" "109.5" "106.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7721582400660787317" "False" "High" "IsMasterProtein" "Q6NVV1" "Putative ribosomal protein uL13-like OS=Homo sapiens OX=9606 GN=RPL13AP3 PE=5 SV=1" "0.000" "False" "8.060" "11" "1" "1" "1" "102" "12.1" "10.76" "4.95" "1" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "other molecular function" "" "" "" "RPL13AP3" "Q6NVV1" "" "" "0" "0" "1.051" "1.357" "1.035" "1.156" "1.218" "1.076" "0.936" "1.233" "1.098" "143.7" "150.9" "194.9" "148.7" "166.1" "175.0" "154.6" "134.5" "177.1" "157.8" "" "" "" "" "" "" "" "" "" "" "115.4" "108.9" "154.8" "99.6" "114.9" "131.3" "108.2" "98.2" "177.1" "128.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3449420204754272229" "False" "High" "IsMasterProtein" "Q9NV56" "MRG/MORF4L-binding protein OS=Homo sapiens OX=9606 GN=MRGBP PE=1 SV=1" "0.000" "False" "8.038" "10" "2" "3" "2" "204" "22.4" "5.83" "9.90" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07904" "55257" "ENSG00000101189" "MRGBP" "A8C4L5; hsa:55257; Q9NV56" "HATs acetylate histones" "" "1" "0" "1.041" "0.896" "1.360" "1.154" "1.103" "1.219" "1.170" "1.221" "1.061" "35.1" "36.6" "31.5" "47.8" "40.6" "38.7" "42.8" "41.1" "42.9" "37.3" "" "" "" "" "" "" "" "" "" "" "28.2" "26.4" "25.0" "32.0" "28.0" "29.1" "30.0" "30.0" "42.9" "30.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5153140893326454359" "False" "High" "IsMasterProtein" "Q99496" "E3 ubiquitin-protein ligase RING2 OS=Homo sapiens OX=9606 GN=RNF2 PE=1 SV=1" "0.000" "False" "8.034" "7" "2" "2" "2" "336" "37.6" "6.84" "7.50" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf16207" "6045" "ENSG00000121481" "RNF2" "B2RBS7; B3KRH1; Q5TEN1; Q5TEN2; Q99496" "Transcriptional Regulation by E2F6; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "11" "0" "1.062" "0.929" "1.054" "0.857" "0.888" "1.112" "0.924" "0.965" "1.039" "203.0" "215.6" "188.6" "214.0" "174.0" "180.2" "225.8" "187.6" "195.8" "210.9" "" "" "" "" "" "" "" "" "" "" "163.1" "155.6" "149.8" "143.3" "120.3" "135.2" "158.1" "137.0" "195.8" "171.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4490493578304001377" "False" "High" "IsMasterProtein" "Q92830" "Histone acetyltransferase KAT2A OS=Homo sapiens OX=9606 GN=KAT2A PE=1 SV=3" "0.000" "False" "8.017" "3" "2" "2" "2" "837" "93.9" "9.04" "7.11" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00439, Pf00583, Pf06466" "2648" "ENSG00000108773" "KAT2A" "hsa:2648; Q8N1A2; Q92830; Q9UCW1" "Ub-specific processing proteases; B-WICH complex positively regulates rRNA expression; Pre-NOTCH Transcription and Translation; HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; RNA Polymerase I Transcription Initiation; Cardiogenesis; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Notch signaling" "17" "0" "0.971" "0.959" "1.037" "0.989" "0.915" "0.999" "1.011" "0.954" "1.064" "265.5" "257.7" "254.6" "275.2" "262.6" "243.0" "265.3" "268.5" "253.2" "282.4" "" "" "" "" "" "" "" "" "" "" "213.2" "186.0" "202.3" "184.4" "181.6" "182.3" "185.7" "196.1" "253.2" "229.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4966290939603233061" "False" "High" "IsMasterProtein" "O00461" "Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1" "0.000" "False" "8.016" "3" "2" "2" "2" "696" "81.8" "4.77" "5.01" "2" "" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "27333" "ENSG00000173905" "GOLIM4" "hsa:27333; O00461" "Intra-Golgi traffic" "" "1" "0" "1.280" "1.350" "1.559" "1.401" "1.199" "1.854" "1.403" "1.495" "1.172" "17.7" "22.7" "23.9" "27.6" "24.8" "21.3" "32.9" "24.9" "26.5" "20.8" "" "" "" "" "" "" "" "" "" "" "14.2" "16.4" "19.0" "18.5" "17.2" "15.9" "23.0" "18.2" "26.5" "16.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1125859041744935918" "False" "High" "IsMasterProtein" "Q96HA7" "Tonsoku-like protein OS=Homo sapiens OX=9606 GN=TONSL PE=1 SV=2" "0.000" "False" "8.011" "3" "3" "3" "3" "1378" "150.8" "6.42" "6.52" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00023, Pf13181, Pf13516" "4796" "ENSG00000160949" "TONSL" "B5MDP0; C9JKB1; C9JNV8; hsa:4796; Q13006; Q96HA7; Q9UGJ2" "" "" "0" "0" "1.140" "0.943" "1.205" "1.048" "1.072" "1.210" "1.491" "1.437" "1.123" "70.9" "80.8" "66.9" "85.4" "74.3" "76.0" "85.8" "105.7" "101.9" "79.6" "" "" "" "" "" "" "" "" "" "" "56.9" "58.3" "53.1" "57.2" "51.4" "57.0" "60.1" "77.2" "101.9" "64.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8184976527645465360" "False" "High" "IsMasterProtein" "Q8N5M4" "Tetratricopeptide repeat protein 9C OS=Homo sapiens OX=9606 GN=TTC9C PE=1 SV=1" "0.000" "False" "8.010" "14" "2" "2" "2" "171" "20.0" "8.92" "5.51" "2" "" "" "" "Pf14559" "283237" "ENSG00000162222" "TTC9C" "hsa:283237; Q8N5M4; Q8WYY7" "" "" "0" "0" "0.847" "0.868" "1.089" "0.912" "0.979" "0.895" "1.180" "0.758" "0.911" "54.4" "46.1" "47.2" "59.3" "49.6" "53.3" "48.7" "64.2" "41.2" "49.6" "" "" "" "" "" "" "" "" "" "" "43.7" "33.3" "37.5" "39.7" "34.3" "40.0" "34.1" "46.9" "41.2" "40.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717347442497409014" "False" "High" "IsMasterProtein" "Q9NXF7" "DDB1- and CUL4-associated factor 16 OS=Homo sapiens OX=9606 GN=DCAF16 PE=1 SV=1" "0.000" "False" "8.004" "12" "3" "3" "3" "216" "24.2" "6.04" "8.79" "3" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf15349" "54876" "ENSG00000163257" "DCAF16" "B3KPB7; hsa:54876; Q9NXF7" "Neddylation" "" "1" "0" "1.091" "0.988" "1.029" "0.949" "1.105" "1.083" "0.929" "0.991" "1.094" "125.5" "137.0" "124.0" "129.2" "119.1" "138.7" "135.9" "116.6" "124.5" "137.3" "" "" "" "" "" "" "" "" "" "" "100.8" "98.8" "98.5" "86.5" "82.4" "104.1" "95.1" "85.2" "124.5" "111.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8653500297928283924" "False" "High" "IsMasterProtein" "Q9H7Z3" "Nuclear exosome regulator NRDE2 OS=Homo sapiens OX=9606 GN=NRDE2 PE=1 SV=3" "0.000" "False" "8.001" "1" "2" "2" "2" "1164" "132.6" "7.68" "5.77" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf08424" "55051" "ENSG00000119720" "NRDE2" "B4DH71; hsa:55051; Q4G0A7; Q9H7Z3; Q9NWH6" "" "" "0" "0" "1.163" "0.974" "1.143" "1.040" "1.228" "1.287" "1.214" "1.358" "1.188" "114.4" "133.1" "111.5" "130.7" "119.0" "140.5" "147.2" "138.9" "155.3" "135.9" "" "" "" "" "" "" "" "" "" "" "91.9" "96.0" "88.6" "87.6" "82.3" "105.4" "103.1" "101.4" "155.3" "110.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-595195611333243081" "False" "High" "IsMasterProtein" "O15265" "Ataxin-7 OS=Homo sapiens OX=9606 GN=ATXN7 PE=1 SV=1" "0.000" "False" "7.985" "2" "1" "1" "1" "892" "95.4" "9.85" "4.76" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf08313" "6314" "ENSG00000163635" "ATXN7" "B4E207; E9PHP9; hsa:6314; O15265; O75328; O75329; Q9Y6P8" "Ub-specific processing proteases; HATs acetylate histones" "" "2" "0" "1.018" "0.959" "1.049" "1.047" "1.101" "1.004" "0.993" "1.107" "1.122" "120.2" "122.4" "115.2" "126.1" "125.9" "132.4" "120.7" "119.3" "133.1" "134.9" "" "" "" "" "" "" "" "" "" "" "96.5" "88.3" "91.5" "84.5" "87.1" "99.3" "84.5" "87.2" "133.1" "109.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8406162996631834722" "False" "High" "IsMasterProtein" "Q7L590" "Protein MCM10 homolog OS=Homo sapiens OX=9606 GN=MCM10 PE=1 SV=2" "0.000" "False" "7.970" "2" "2" "2" "2" "875" "98.1" "8.75" "6.14" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf09329, Pf09332" "55388" "ENSG00000065328" "MCM10" "A8K9I6; B7ZKZ8; hsa:55388; Q3MIR3; Q7L590; Q7LD55; Q96GX4; Q96NB6; Q9H0D7; Q9H3P9; Q9P177" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex" "Ciliary landscape; DNA replication" "4" "0" "1.277" "1.011" "1.594" "1.302" "1.099" "2.044" "1.903" "1.674" "1.331" "121.8" "155.6" "123.2" "194.2" "158.7" "134.0" "249.0" "231.9" "204.0" "162.2" "" "" "" "" "" "" "" "" "" "" "97.9" "112.3" "97.9" "130.1" "109.7" "100.5" "174.4" "169.3" "204.0" "131.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8604308957137322217" "False" "High" "IsMasterProtein" "Q8IXQ5" "Kelch-like protein 7 OS=Homo sapiens OX=9606 GN=KLHL7 PE=1 SV=2" "0.000" "False" "7.961" "3" "2" "2" "2" "586" "65.9" "6.48" "6.59" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "55975" "ENSG00000122550" "KLHL7" "A4D144; B7Z5I9; G5E9G3; hsa:55975; Q7Z765; Q8IXQ5; Q96MV2; Q9BQF8; Q9UDQ9" "" "" "0" "0" "1.003" "1.000" "1.052" "1.093" "1.024" "1.017" "1.048" "1.133" "1.123" "275.4" "276.3" "275.2" "289.8" "301.0" "282.1" "280.1" "288.5" "312.0" "309.1" "" "" "" "" "" "" "" "" "" "" "221.2" "199.3" "218.6" "194.2" "208.2" "211.6" "196.1" "210.7" "312.0" "251.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4691271095298353856" "False" "High" "IsMasterProtein" "Q13114" "TNF receptor-associated factor 3 OS=Homo sapiens OX=9606 GN=TRAF3 PE=1 SV=2" "0.000" "False" "7.951" "4" "3" "3" "2" "568" "64.4" "7.91" "8.79" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf21355, Pf21363" "7187" "ENSG00000131323" "TRAF3" "B7Z8C4; hsa:7187; Q12990; Q13076; Q13114; Q13947; Q6AZX1; Q9UNL1" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Negative regulators of DDX58/IFIH1 signaling; TRAF3 deficiency - HSE; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; miRNA role in immune response in sepsis; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Type I interferon induction and signaling during SARS-CoV-2 infection; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 2q37 copy number variation syndrome; 13q12.12 copy number variation; Toll-like receptor signaling pathway" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277143730567108241" "False" "High" "IsMasterProtein" "Q7Z6L1" "Tectonin beta-propeller repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TECPR1 PE=1 SV=1" "0.000" "False" "7.938" "3" "3" "3" "3" "1165" "129.6" "6.24" "8.49" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf06398, Pf06462, Pf19193" "25851" "ENSG00000205356" "TECPR1" "A8KAD1; B3KPZ1; C9J024; F5GX57; hsa:25851; Q7Z6L1; Q96EB0; Q9P2I9; Q9UFR6" "" "" "0" "0" "1.114" "0.996" "0.951" "1.240" "0.990" "1.029" "0.978" "0.958" "0.992" "43.6" "48.6" "43.4" "41.5" "54.0" "43.2" "44.8" "42.6" "41.8" "43.2" "" "" "" "" "" "" "" "" "" "" "35.0" "35.1" "34.5" "27.8" "37.4" "32.4" "31.4" "31.1" "41.8" "35.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2663740038882364516" "False" "High" "IsMasterProtein" "Q96S82" "Ubiquitin-like protein 7 OS=Homo sapiens OX=9606 GN=UBL7 PE=1 SV=2" "0.000" "False" "7.930" "6" "2" "4" "2" "380" "40.5" "5.07" "7.96" "2" "protein metabolism;other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00240" "84993" "ENSG00000138629; ENSG00000288408" "UBL7" "D3DW57; hsa:84993; Q96I03; Q96S82" "" "" "0" "0" "1.012" "1.057" "1.100" "1.045" "1.105" "1.037" "1.040" "1.029" "1.057" "370.2" "374.8" "391.1" "407.1" "386.7" "409.0" "383.8" "385.2" "380.8" "391.4" "" "" "" "" "" "" "" "" "" "" "297.3" "270.4" "310.7" "272.8" "267.4" "306.9" "268.7" "281.3" "380.8" "318.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629743064100226613" "False" "High" "IsMasterProtein" "Q8TAK5" "GA-binding protein subunit beta-2 OS=Homo sapiens OX=9606 GN=GABPB2 PE=1 SV=1" "0.000" "False" "7.929" "5" "2" "2" "2" "448" "48.6" "5.26" "8.66" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12796" "126626" "ENSG00000143458" "GABPB2" "B1AVJ8; D3DV14; hsa:126626; Q8NAR5; Q8TAK5" "" "" "0" "0" "0.878" "1.046" "0.958" "1.005" "1.140" "0.883" "0.849" "0.941" "1.071" "86.1" "75.7" "90.1" "82.5" "86.5" "98.2" "76.1" "73.1" "81.0" "92.2" "" "" "" "" "" "" "" "" "" "" "69.2" "54.6" "71.6" "55.3" "59.9" "73.7" "53.3" "53.4" "81.0" "75.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3648988752962304061" "False" "High" "IsMasterProtein" "Q96DY2" "Dynein regulatory complex protein 10 OS=Homo sapiens OX=9606 GN=IQCD PE=1 SV=2" "0.000" "False" "7.911" "4" "2" "3" "2" "449" "52.3" "9.25" "10.10" "2" "" "cytoskeleton;other cell component" "" "Pf00612" "115811" "ENSG00000166578" "IQCD" "hsa:115811; Q6ZSU0; Q96DY2" "" "" "0" "0" "1.168" "1.033" "1.029" "1.045" "0.989" "0.914" "0.998" "0.879" "1.037" "491.9" "574.7" "508.0" "506.3" "513.9" "486.3" "449.7" "490.9" "432.6" "510.0" "" "" "" "" "" "" "" "" "" "" "395.1" "414.7" "403.6" "339.2" "355.4" "364.9" "314.8" "358.5" "432.6" "414.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1834227978876737947" "False" "High" "IsMasterProtein" "Q96EP1" "E3 ubiquitin-protein ligase CHFR OS=Homo sapiens OX=9606 GN=CHFR PE=1 SV=2" "0.000" "False" "7.908" "3" "2" "2" "2" "664" "73.3" "6.04" "3.47" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00498, Pf13923, Pf17979" "55743" "ENSG00000072609" "CHFR" "A6NEN5; B4DZ77; B4E2L6; hsa:55743; Q96EP1; Q96SL3; Q9NRT4; Q9NT32; Q9NVD5" "" "" "0" "0" "0.935" "1.200" "0.929" "1.169" "1.172" "1.047" "1.166" "0.968" "1.116" "39.7" "37.1" "47.6" "36.9" "46.4" "46.5" "41.6" "46.3" "38.4" "44.3" "" "" "" "" "" "" "" "" "" "" "31.9" "26.8" "37.8" "24.7" "32.1" "34.9" "29.1" "33.8" "38.4" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1095568573092082412" "False" "High" "IsMasterProtein" "Q16762" "Thiosulfate sulfurtransferase OS=Homo sapiens OX=9606 GN=TST PE=1 SV=4" "0.000" "False" "7.881" "10" "2" "2" "2" "297" "33.4" "7.25" "5.68" "2" "other metabolic processes;transport;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00581" "7263" "ENSG00000128311" "TST" "B3KRM1; hsa:7263; Q16762; Q6IB06" "Sulfide oxidation to sulfate" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5677827102624180499" "False" "High" "IsMasterProtein" "Q96IQ9" "Zinc finger protein 414 OS=Homo sapiens OX=9606 GN=ZNF414 PE=1 SV=2" "0.000" "False" "7.880" "11" "3" "4" "3" "312" "32.8" "7.81" "11.87" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15909" "84330" "ENSG00000133250" "ZNF414" "A8MY94; hsa:84330; Q96IQ9" "" "" "0" "0" "1.018" "1.015" "1.025" "0.979" "1.042" "0.913" "0.937" "0.953" "1.040" "287.6" "292.8" "291.8" "294.8" "281.5" "299.6" "262.5" "269.4" "274.1" "299.2" "" "" "" "" "" "" "" "" "" "" "231.0" "211.2" "231.8" "197.5" "194.7" "224.8" "183.8" "196.7" "274.1" "243.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1163479786593158346" "False" "High" "IsMasterProtein" "Q9NP64" "Zinc finger CCHC domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ZCCHC17 PE=1 SV=1" "0.000" "False" "7.876" "10" "2" "2" "2" "241" "27.6" "9.70" "6.19" "2" "other biological processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf00575" "51538" "ENSG00000121766" "ZCCHC17" "B4DY38; D3DPN4; hsa:51538; Q6PKH4; Q9NP64; Q9NYG4; Q9P0M8" "" "" "0" "0" "1.116" "1.288" "1.087" "1.232" "1.176" "1.221" "1.105" "1.094" "0.970" "83.2" "92.9" "107.2" "90.5" "102.5" "97.8" "101.6" "92.0" "91.1" "80.7" "" "" "" "" "" "" "" "" "" "" "66.8" "67.0" "85.1" "60.6" "70.9" "73.4" "71.1" "67.2" "91.1" "65.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6009675423733223461" "False" "High" "IsMasterProtein" "Q96B54" "Zinc finger protein 428 OS=Homo sapiens OX=9606 GN=ZNF428 PE=1 SV=2" "0.000" "False" "7.871" "6" "1" "1" "1" "188" "20.5" "4.17" "4.41" "1" "" "" "other molecular function" "" "126299" "ENSG00000131116" "ZNF428" "hsa:126299; O95054; Q6X3Y3; Q96B54" "" "" "0" "0" "0.933" "0.849" "0.909" "0.858" "0.930" "0.946" "1.000" "0.951" "0.866" "158.4" "147.8" "134.5" "144.0" "135.9" "147.3" "149.8" "158.4" "150.6" "137.1" "" "" "" "" "" "" "" "" "" "" "127.2" "106.6" "106.8" "96.5" "94.0" "110.5" "104.9" "115.7" "150.6" "111.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327370381573557729" "False" "High" "IsMasterProtein" "Q99611" "Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3" "0.000" "False" "7.851" "7" "3" "3" "2" "448" "47.3" "5.88" "8.65" "3" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22928" "ENSG00000179918" "SEPHS2" "hsa:22928; Q99611; Q9BUQ2" "Selenocysteine synthesis" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "3" "0" "0.951" "1.382" "0.906" "1.153" "1.017" "1.124" "1.105" "0.979" "1.168" "26.1" "24.8" "36.0" "23.6" "30.1" "26.5" "29.3" "28.8" "25.5" "30.4" "" "" "" "" "" "" "" "" "" "" "20.9" "17.9" "28.6" "15.8" "20.8" "19.9" "20.5" "21.0" "25.5" "24.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841381739766448706" "False" "High" "IsMasterProtein" "Q2M296" "Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens OX=9606 GN=MTHFSD PE=1 SV=2" "0.000" "False" "7.850" "7" "3" "3" "3" "383" "42.1" "8.73" "9.53" "3" "" "other cell component" "" "Pf00076, Pf01812" "64779" "ENSG00000103248" "MTHFSD" "A8MQ77; B7ZLC0; B7ZLC2; D3DUM9; E9PAM1; hsa:64779; Q2M296; Q9H878; Q9H954" "" "" "0" "0" "1.039" "1.105" "0.980" "1.063" "1.040" "1.072" "1.192" "1.120" "1.179" "155.1" "161.1" "171.4" "151.9" "164.8" "161.3" "166.2" "184.8" "173.6" "182.8" "" "" "" "" "" "" "" "" "" "" "124.5" "116.2" "136.1" "101.8" "114.0" "121.0" "116.3" "135.0" "173.6" "148.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4744508132045603899" "False" "High" "IsMasterProtein" "Q9BZG8" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=3" "0.000" "False" "7.847" "5" "3" "5" "3" "438" "48.1" "7.84" "12.35" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01866" "1801" "ENSG00000108963" "DPH1" "A0A6Q8JGF9; D3DTI3; hsa:1801; Q16439; Q4VBA2; Q9BTW7; Q9BZG8; Q9UCY0" "Synthesis of diphthamide-EEF2" "" "1" "0" "1.095" "1.060" "1.225" "1.034" "0.931" "1.022" "1.085" "1.131" "1.135" "119.2" "130.5" "126.4" "146.0" "123.3" "111.0" "121.8" "129.4" "134.8" "135.2" "" "" "" "" "" "" "" "" "" "" "95.7" "94.2" "100.4" "97.8" "85.3" "83.3" "85.3" "94.5" "134.8" "110.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6067622255201761803" "False" "High" "IsMasterProtein" "O95059" "Ribonuclease P protein subunit p14 OS=Homo sapiens OX=9606 GN=RPP14 PE=1 SV=3" "0.000" "False" "7.844" "19" "3" "5" "3" "124" "13.7" "7.75" "9.91" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "11102" "ENSG00000163684" "RPP14" "O95059; Q53X97" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "1.443" "0.945" "1.328" "1.023" "0.961" "1.147" "0.862" "0.956" "1.060" "72.3" "104.4" "68.4" "96.1" "74.0" "69.5" "83.0" "62.4" "69.2" "76.7" "" "" "" "" "" "" "" "" "" "" "58.1" "75.3" "54.3" "64.4" "51.2" "52.1" "58.1" "45.5" "69.2" "62.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945913478307562709" "False" "High" "IsMasterProtein" "Q9Y2Q9" "Small ribosomal subunit protein bS1m OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "0.000" "False" "7.837" "12" "3" "3" "3" "187" "20.8" "9.10" "9.23" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.933" "1.050" "0.924" "1.008" "0.969" "0.857" "0.965" "0.867" "0.950" "251.6" "234.8" "264.2" "232.5" "253.6" "243.9" "215.8" "242.9" "218.3" "239.1" "" "" "" "" "" "" "" "" "" "" "202.1" "169.4" "209.8" "155.8" "175.4" "183.0" "151.1" "177.4" "218.3" "194.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174289831199594781" "False" "High" "IsMasterProtein" "Q2KHR3" "Glutamine and serine-rich protein 1 OS=Homo sapiens OX=9606 GN=QSER1 PE=1 SV=3" "0.000" "False" "7.806" "1" "1" "1" "1" "1735" "189.9" "7.08" "4.56" "1" "" "other cell component" "" "Pf13926" "79832" "" "QSER1" "hsa:79832; Q2KHR3; Q6ZU30; Q6ZUR5" "" "" "0" "0" "1.010" "1.033" "1.181" "0.980" "0.839" "0.994" "1.087" "1.153" "1.016" "50.4" "50.9" "52.1" "59.5" "49.4" "42.3" "50.1" "54.8" "58.1" "51.2" "" "" "" "" "" "" "" "" "" "" "40.5" "36.7" "41.4" "39.9" "34.2" "31.7" "35.1" "40.0" "58.1" "41.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1812058185286656363" "False" "High" "IsMasterProtein" "Q9NWZ8" "Gem-associated protein 8 OS=Homo sapiens OX=9606 GN=GEMIN8 PE=1 SV=1" "0.000" "False" "7.799" "8" "2" "2" "2" "242" "28.6" "6.80" "7.08" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15348" "54960" "ENSG00000046647" "GEMIN8" "C4AMC4; hsa:54960; Q2LJ66; Q6ZV27; Q9NWZ8" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "1.055" "0.965" "1.051" "1.015" "1.076" "1.011" "1.027" "0.991" "1.067" "401.8" "423.9" "387.8" "422.3" "407.7" "432.4" "406.3" "412.4" "398.2" "428.6" "" "" "" "" "" "" "" "" "" "" "322.7" "305.9" "308.0" "282.9" "282.0" "324.4" "284.4" "301.2" "398.2" "348.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1168885672839203187" "False" "High" "IsMasterProtein" "Q9HC52" "Chromobox protein homolog 8 OS=Homo sapiens OX=9606 GN=CBX8 PE=1 SV=3" "0.000" "False" "7.789" "6" "2" "2" "2" "389" "43.4" "9.91" "7.19" "2" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00385, Pf17218" "57332" "ENSG00000141570" "CBX8" "hsa:57332; Q96H39; Q9HC52; Q9NR07" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription" "" "8" "0" "1.076" "1.103" "1.109" "1.013" "1.029" "0.974" "0.780" "1.045" "1.048" "72.1" "77.6" "79.5" "79.9" "73.1" "74.2" "70.3" "56.2" "75.3" "75.6" "" "" "" "" "" "" "" "" "" "" "57.9" "56.0" "63.2" "53.6" "50.5" "55.7" "49.2" "41.1" "75.3" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7807637693933670842" "False" "High" "IsMasterProtein" "Q8NB91" "Fanconi anemia group B protein OS=Homo sapiens OX=9606 GN=FANCB PE=1 SV=1" "0.000" "False" "7.740" "3" "3" "3" "3" "859" "97.7" "7.61" "7.37" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "" "2187" "ENSG00000181544" "FANCB" "B2RMZ4; hsa:2187; Q7Z2U2; Q86XG1; Q8NB91" "Fanconi Anemia Pathway; PKR-mediated signaling" "DNA repair pathways, full network" "3" "0" "0.825" "0.974" "1.168" "1.084" "0.913" "1.031" "1.221" "0.990" "1.179" "63.2" "52.1" "61.5" "73.8" "68.5" "57.7" "65.2" "77.2" "62.6" "74.5" "" "" "" "" "" "" "" "" "" "" "50.8" "37.6" "48.9" "49.5" "47.4" "43.3" "45.6" "56.3" "62.6" "60.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8206347650273111002" "False" "High" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "0.000" "False" "7.735" "13" "2" "2" "2" "122" "13.3" "8.46" "5.75" "2" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "0.955" "0.857" "0.912" "0.900" "0.804" "0.931" "0.964" "0.809" "0.828" "118.7" "113.3" "101.8" "108.3" "106.8" "95.4" "110.5" "114.3" "96.1" "98.3" "" "" "" "" "" "" "" "" "" "" "95.3" "81.8" "80.8" "72.5" "73.8" "71.6" "77.3" "83.5" "96.1" "79.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5331704730055142476" "False" "High" "IsMasterProtein" "Q8IVB5" "LIX1-like protein OS=Homo sapiens OX=9606 GN=LIX1L PE=1 SV=1" "0.000" "False" "7.733" "8" "3" "3" "3" "337" "36.5" "8.56" "9.79" "3" "cell organization and biogenesis;other metabolic processes" "other cell component" "" "Pf14954" "128077" "ENSG00000271601" "LIX1L" "hsa:128077; Q6AI36; Q8IVB5" "" "" "0" "0" "1.121" "1.045" "1.054" "1.117" "1.061" "0.904" "0.915" "0.992" "1.014" "301.1" "337.5" "314.8" "317.2" "336.2" "319.6" "272.3" "275.6" "298.7" "305.5" "" "" "" "" "" "" "" "" "" "" "241.9" "243.5" "250.1" "212.6" "232.5" "239.8" "190.6" "201.3" "298.7" "248.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330094663577244460" "False" "High" "IsMasterProtein" "Q13049" "E3 ubiquitin-protein ligase TRIM32 OS=Homo sapiens OX=9606 GN=TRIM32 PE=1 SV=2" "0.000" "False" "7.724" "4" "2" "2" "2" "653" "71.9" "6.98" "7.00" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01436, Pf13445" "22954" "ENSG00000119401" "TRIM32" "hsa:22954; Q13049; Q9NQP8" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA" "Ciliopathies; Bardet-Biedl syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8287217106573217655" "False" "High" "IsMasterProtein" "Q92540" "Nonsense-mediated mRNA decay factor SMG7 OS=Homo sapiens OX=9606 GN=SMG7 PE=1 SV=2" "0.000" "False" "7.719" "2" "2" "2" "2" "1137" "127.2" "8.72" "5.69" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374" "9887" "ENSG00000116698" "SMG7" "B4DRB2; E9PCI0; E9PEH2; hsa:9887; Q5T1Q0; Q6PIE0; Q7Z7H9; Q8IXC1; Q8IXC2; Q92540" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "1.187" "1.107" "1.243" "1.004" "1.135" "1.155" "1.571" "1.188" "1.229" "73.4" "87.2" "81.3" "91.3" "73.7" "83.3" "84.8" "115.4" "87.2" "90.2" "" "" "" "" "" "" "" "" "" "" "59.0" "62.9" "64.6" "61.2" "51.0" "62.5" "59.4" "84.3" "87.2" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6940581547763936040" "False" "High" "IsMasterProtein" "Q9NUL3" "Double-stranded RNA-binding protein Staufen homolog 2 OS=Homo sapiens OX=9606 GN=STAU2 PE=1 SV=2" "0.000" "False" "7.716" "3" "2" "2" "1" "570" "62.6" "9.61" "6.76" "2" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "27067" "ENSG00000040341" "STAU2" "A0A0A0MTC5; B7Z1I6; B7Z292; B7Z8B4; E7ER74; E9PEI3; E9PF26; E9PF50; hsa:27067; Q6AHY7; Q96HM0; Q96HM1; Q9NUL3; Q9NVI5; Q9UGG6" "" "" "0" "0" "1.040" "0.648" "1.050" "1.198" "1.070" "0.928" "0.951" "1.046" "0.942" "87.2" "90.7" "56.6" "91.6" "104.5" "93.3" "80.9" "83.0" "91.3" "82.2" "" "" "" "" "" "" "" "" "" "" "70.1" "65.5" "44.9" "61.4" "72.3" "70.0" "56.6" "60.6" "91.3" "66.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8694247867552348247" "False" "High" "IsMasterProtein" "Q9BQ75" "Protein CMSS1 OS=Homo sapiens OX=9606 GN=CMSS1 PE=1 SV=2" "0.000" "False" "7.680" "6" "2" "2" "2" "279" "31.9" "9.19" "6.86" "2" "" "" "" "Pf14617" "84319" "ENSG00000184220" "CMSS1" "A8K5S7; B4DUM1; E9PHS3; hsa:84319; Q9BQ75" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "307320246962858459" "False" "High" "IsMasterProtein" "Q6UWZ7" "BRCA1-A complex subunit Abraxas 1 OS=Homo sapiens OX=9606 GN=ABRAXAS1 PE=1 SV=2" "0.000" "False" "7.671" "7" "3" "4" "3" "409" "46.6" "7.05" "6.57" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "cytoskeletal activity;other molecular function" "Pf21125" "84142" "ENSG00000163322" "ABRAXAS1" "A5JJ07; hsa:84142; Q6UWZ7; Q9H8I1; Q9H9N4" "Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint" "5q35 copy number variation" "6" "0" "1.115" "0.781" "0.863" "0.965" "0.888" "0.942" "0.764" "1.054" "0.839" "41.6" "46.4" "32.5" "35.9" "40.2" "36.9" "39.2" "31.8" "43.9" "34.9" "" "" "" "" "" "" "" "" "" "" "33.4" "33.5" "25.8" "24.1" "27.8" "27.7" "27.4" "23.2" "43.9" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653544174487068262" "False" "High" "IsMasterProtein" "O00479" "High mobility group nucleosome-binding domain-containing protein 4 OS=Homo sapiens OX=9606 GN=HMGN4 PE=1 SV=3" "0.000" "False" "7.670" "18" "2" "4" "2" "90" "9.5" "10.48" "10.06" "2" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "10473" "ENSG00000182952; ENSG00000292175" "HMGN4" "B2R4I6; hsa:10473; O00479; Q53XL9" "" "" "0" "0" "0.919" "0.951" "0.861" "1.003" "0.857" "1.227" "0.965" "1.266" "1.081" "30.5" "28.0" "29.0" "26.2" "30.6" "26.1" "37.4" "29.4" "38.6" "32.9" "" "" "" "" "" "" "" "" "" "" "24.5" "20.2" "23.0" "17.6" "21.2" "19.6" "26.2" "21.5" "38.6" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2714987798271116551" "False" "High" "IsMasterProtein" "Q9BUE0" "Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1" "0.000" "False" "7.664" "14" "2" "2" "2" "208" "23.6" "6.54" "5.14" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09637" "54797" "ENSG00000130772; ENSG00000284944" "MED18" "D3DPM1; hsa:54797; Q9BUE0; Q9NXU9" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4571084566871798353" "False" "High" "IsMasterProtein" "Q9Y2S6" "Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1" "0.000" "False" "7.646" "14" "1" "6" "1" "64" "7.1" "9.99" "20.11" "1" "" "" "" "Pf09072" "51372" "ENSG00000232112" "TMA7" "hsa:51372; Q9P052; Q9Y2S6" "" "" "0" "0" "1.013" "1.005" "0.964" "0.930" "0.953" "0.957" "0.941" "0.936" "0.926" "1051.6" "1065.7" "1057.2" "1014.3" "978.2" "1002.4" "1006.3" "990.1" "984.7" "974.1" "" "" "" "" "" "" "" "" "" "" "844.7" "769.0" "839.7" "679.5" "676.6" "752.1" "704.6" "723.1" "984.7" "792.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1549161421235899806" "False" "High" "IsMasterProtein" "Q96EH3" "Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1" "0.000" "False" "7.644" "9" "1" "1" "1" "234" "26.2" "5.49" "4.30" "1" "other biological processes" "cytosol;mitochondrion" "translation activity" "Pf02410" "115416" "ENSG00000156928" "MALSU1" "A4D154; hsa:115416; Q96EH3" "" "" "0" "0" "0.985" "1.026" "1.133" "1.013" "0.992" "1.041" "1.059" "1.059" "0.969" "260.5" "256.5" "267.3" "295.3" "263.9" "258.5" "271.3" "276.0" "275.8" "252.6" "" "" "" "" "" "" "" "" "" "" "209.2" "185.1" "212.3" "197.8" "182.5" "193.9" "189.9" "201.6" "275.8" "205.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1991915273317640998" "False" "High" "IsMasterProtein" "O00463" "TNF receptor-associated factor 5 OS=Homo sapiens OX=9606 GN=TRAF5 PE=1 SV=2" "0.000" "False" "7.639" "3" "2" "2" "1" "557" "64.4" "7.43" "6.46" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf21355, Pf21363" "7188" "ENSG00000082512" "TRAF5" "B4DIS9; B4E0A2; hsa:7188; O00463; Q6FHY1" "" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; 1p36 copy number variation syndrome; 13q12.12 copy number variation" "8" "0" "1.048" "1.080" "1.086" "1.150" "1.093" "1.213" "1.094" "1.079" "1.162" "193.7" "202.9" "209.2" "210.4" "222.7" "211.6" "234.9" "211.9" "209.0" "225.1" "" "" "" "" "" "" "" "" "" "" "155.6" "146.4" "166.2" "141.0" "154.0" "158.8" "164.4" "154.7" "209.0" "183.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5020474961382465415" "False" "High" "IsMasterProtein" "Q9NXG6" "Transmembrane prolyl 4-hydroxylase OS=Homo sapiens OX=9606 GN=P4HTM PE=1 SV=2" "0.000" "False" "7.639" "5" "2" "2" "2" "502" "56.6" "6.06" "6.64" "2" "other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf13499, Pf13640" "54681" "ENSG00000178467" "P4HTM" "hsa:54681; Q6PAG6; Q8TCJ9; Q8WV55; Q96F22; Q9BW77; Q9NXG6" "" "" "0" "0" "1.064" "0.881" "1.124" "1.153" "1.129" "1.176" "1.020" "1.045" "1.140" "129.9" "138.3" "114.4" "146.1" "149.9" "146.7" "152.9" "132.6" "135.8" "148.1" "" "" "" "" "" "" "" "" "" "" "104.4" "99.8" "90.9" "97.9" "103.7" "110.1" "107.0" "96.8" "135.8" "120.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949973540921292373" "False" "High" "IsMasterProtein" "P40425" "Pre-B-cell leukemia transcription factor 2 OS=Homo sapiens OX=9606 GN=PBX2 PE=1 SV=2" "0.000" "False" "7.632" "7" "2" "2" "2" "430" "45.9" "7.56" "6.50" "2" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03792, Pf05920" "5089" "ENSG00000204304; ENSG00000206315; ENSG00000224952; ENSG00000225987; ENSG00000232005; ENSG00000236353; ENSG00000237344" "PBX2" "A2BFJ2; hsa:5089; P40425" "" "" "0" "0" "0.907" "0.960" "0.976" "0.859" "1.158" "1.159" "1.079" "1.166" "1.121" "59.1" "53.6" "56.7" "57.7" "50.8" "68.5" "68.5" "63.8" "68.9" "66.3" "" "" "" "" "" "" "" "" "" "" "47.5" "38.7" "45.1" "38.6" "35.1" "51.4" "48.0" "46.6" "68.9" "53.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4410933930265088231" "False" "High" "IsMasterProtein" "P14927" "Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2" "0.000" "False" "7.621" "10" "1" "1" "1" "111" "13.5" "8.78" "5.17" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02271" "7381" "ENSG00000156467" "UQCRB" "E5RJU0; hsa:7381; P14927; Q6FGD1" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "1.068" "1.129" "1.358" "1.319" "1.355" "1.197" "1.139" "1.320" "1.236" "250.6" "267.5" "283.0" "340.3" "330.6" "339.6" "299.9" "285.3" "330.8" "309.6" "" "" "" "" "" "" "" "" "" "" "201.3" "193.0" "224.8" "228.0" "228.7" "254.8" "210.0" "208.3" "330.8" "251.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153157307515931541" "False" "High" "IsMasterProtein" "Q9UBI9" "Headcase protein homolog OS=Homo sapiens OX=9606 GN=HECA PE=1 SV=1" "0.000" "False" "7.605" "4" "2" "2" "2" "543" "58.8" "8.54" "7.88" "2" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf15353, Pf16002" "51696" "ENSG00000112406" "HECA" "hsa:51696; Q9UBI9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4267649899047478727" "False" "High" "IsMasterProtein" "Q92562" "Polyphosphoinositide phosphatase OS=Homo sapiens OX=9606 GN=FIG4 PE=1 SV=1" "0.000" "False" "7.596" "2" "2" "2" "2" "907" "103.6" "6.92" "5.24" "2" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02383" "9896" "ENSG00000112367" "FIG4" "hsa:9896; Q53H49; Q5TCS6; Q92562" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "Intracellular trafficking proteins involved in CMT neuropathy" "4" "0" "1.038" "0.986" "1.114" "1.100" "0.878" "1.065" "0.920" "1.004" "0.936" "132.5" "137.5" "130.6" "147.5" "145.7" "116.2" "141.1" "121.8" "133.0" "124.0" "" "" "" "" "" "" "" "" "" "" "106.4" "99.2" "103.8" "98.8" "100.8" "87.2" "98.8" "89.0" "133.0" "100.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537965283186170392" "False" "High" "IsMasterProtein" "Q9UM13" "Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1" "0.000" "False" "7.582" "11" "2" "2" "2" "185" "21.2" "9.06" "6.67" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf03256" "10393" "ENSG00000164162" "ANAPC10" "D3DNZ7; hsa:10393; Q2V500; Q9UG51; Q9UM13; Q9Y5R0" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.123" "1.011" "1.084" "0.954" "0.982" "0.980" "1.118" "1.119" "1.011" "60.5" "67.9" "61.1" "65.5" "57.7" "59.4" "59.3" "67.6" "67.7" "61.2" "" "" "" "" "" "" "" "" "" "" "48.6" "49.0" "48.6" "43.9" "39.9" "44.5" "41.5" "49.4" "67.7" "49.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243510255652215024" "False" "High" "IsMasterProtein" "Q9Y448" "Small kinetochore-associated protein OS=Homo sapiens OX=9606 GN=KNSTRN PE=1 SV=2" "0.000" "False" "7.574" "9" "3" "3" "2" "316" "35.4" "6.30" "6.29" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "90417" "ENSG00000128944" "KNSTRN" "B4DXA7; hsa:90417; Q147U5; Q32Q57; Q5ISJ0; Q6P2S5; Q6PJM0; Q86XB4; Q9Y448" "" "Leukocyte-intrinsic Hippo pathway functions" "1" "0" "1.113" "1.237" "1.187" "1.137" "0.960" "0.995" "1.444" "0.749" "0.913" "14.2" "15.8" "17.5" "16.8" "16.1" "13.6" "14.1" "20.4" "10.6" "12.9" "" "" "" "" "" "" "" "" "" "" "11.4" "11.4" "13.9" "11.3" "11.1" "10.2" "9.9" "14.9" "10.6" "10.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1805592529693250649" "False" "High" "IsMasterProtein" "Q9BYE7" "Polycomb group RING finger protein 6 OS=Homo sapiens OX=9606 GN=PCGF6 PE=1 SV=2" "0.000" "False" "7.562" "5" "2" "2" "2" "350" "39.0" "4.97" "6.57" "2" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf13923, Pf16207" "84108" "ENSG00000156374" "PCGF6" "A8K3R4; hsa:84108; Q5SYD1; Q5SYD6; Q96ID9; Q96SJ1; Q9BYE7" "Transcriptional Regulation by E2F6" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265471816786777464" "False" "High" "IsMasterProtein" "Q9Y657" "Spindlin-1 OS=Homo sapiens OX=9606 GN=SPIN1 PE=1 SV=3" "0.000" "False" "7.556" "10" "2" "2" "2" "262" "29.6" "6.96" "6.41" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02513" "10927" "ENSG00000106723" "SPIN1" "A8K0X6; B3KRQ4; hsa:10927; Q7KZJ8; Q9GZT2; Q9H0N7; Q9Y657" "" "" "0" "0" "1.079" "0.930" "1.076" "0.964" "0.963" "1.211" "0.805" "0.886" "1.162" "54.9" "59.2" "51.1" "59.1" "52.9" "52.9" "66.5" "44.2" "48.6" "63.8" "" "" "" "" "" "" "" "" "" "" "44.1" "42.7" "40.6" "39.6" "36.6" "39.7" "46.5" "32.3" "48.6" "51.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855179925451267268" "False" "High" "IsMasterProtein" "Q96F24" "Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1" "0.000" "False" "7.553" "6" "2" "2" "2" "287" "32.4" "5.87" "7.45" "2" "other metabolic processes;stress response" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08961, Pf17169" "29982" "ENSG00000148572" "NRBF2" "A6PW36; B4DWS0; hsa:29982; Q86UR2; Q96F24; Q96NP6; Q9H0S9; Q9H2I2" "" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5068245923404983933" "False" "High" "IsMasterProtein" "P53671" "LIM domain kinase 2 OS=Homo sapiens OX=9606 GN=LIMK2 PE=1 SV=1" "0.000" "False" "7.542" "3" "2" "2" "2" "638" "72.2" "7.20" "7.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00412, Pf00595, Pf07714" "3985" "ENSG00000182541" "LIMK2" "A8K6H5; hsa:3985; P53671; Q7KZ80; Q7L3H5; Q96E10; Q99464; Q9UFU0" "EPHB-mediated forward signaling; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs" "Androgen receptor signaling pathway; TGF-beta signaling pathway; EGF/EGFR signaling pathway" "6" "0" "0.928" "1.055" "0.969" "1.011" "0.962" "1.049" "1.111" "1.012" "0.996" "423.8" "393.2" "447.0" "410.5" "428.4" "407.8" "444.7" "470.6" "428.7" "421.9" "" "" "" "" "" "" "" "" "" "" "340.4" "283.8" "355.1" "275.0" "296.3" "306.0" "311.3" "343.7" "428.7" "343.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1244063578202926483" "False" "High" "IsMasterProtein" "Q68D10" "Protein SPT2 homolog OS=Homo sapiens OX=9606 GN=SPTY2D1 PE=1 SV=3" "0.000" "False" "7.535" "3" "2" "2" "2" "685" "75.6" "9.79" "5.55" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08243" "144108" "ENSG00000179119" "SPTY2D1" "hsa:144108; Q68D10; Q6AWA5; Q6MZI5; Q7Z390; Q7Z470; Q86VG8; Q8N3E7; Q8N417; Q8N8I3" "" "" "0" "0" "0.888" "1.017" "1.028" "1.201" "0.968" "1.409" "1.293" "1.058" "0.882" "30.8" "27.4" "31.4" "31.7" "37.0" "29.8" "43.4" "39.9" "32.6" "27.2" "" "" "" "" "" "" "" "" "" "" "24.8" "19.7" "24.9" "21.2" "25.6" "22.4" "30.4" "29.1" "32.6" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011365371626777610" "False" "High" "IsMasterProtein" "P56277" "Cx9C motif-containing protein 4 OS=Homo sapiens OX=9606 GN=CMC4 PE=1 SV=1" "0.000" "False" "7.529" "25" "2" "2" "2" "68" "7.7" "8.18" "7.86" "2" "" "mitochondrion" "" "Pf08991" "100272147" "ENSG00000182712" "CMC4" "hsa:100272147; P56277; Q5HYP9" "Mitochondrial protein import" "" "1" "0" "1.077" "0.984" "0.987" "0.953" "1.021" "1.053" "1.053" "1.094" "0.981" "473.2" "509.7" "465.5" "467.3" "450.8" "483.3" "498.2" "498.4" "517.7" "464.4" "" "" "" "" "" "" "" "" "" "" "380.1" "367.8" "369.8" "313.1" "311.8" "362.6" "348.8" "364.0" "517.7" "377.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7392710609967527407" "False" "High" "IsMasterProtein" "Q96BH1" "E3 ubiquitin-protein ligase RNF25 OS=Homo sapiens OX=9606 GN=RNF25 PE=1 SV=1" "0.000" "False" "7.518" "4" "2" "3" "2" "459" "51.2" "6.54" "7.88" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf05773, Pf13639" "64320" "ENSG00000163481" "RNF25" "A8K0D6; hsa:64320; Q53HQ5; Q96BH1; Q9H874" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.073" "1.077" "1.133" "1.110" "1.060" "1.116" "1.047" "1.114" "1.052" "283.4" "304.1" "305.3" "321.1" "314.4" "300.5" "316.3" "296.8" "315.8" "298.2" "" "" "" "" "" "" "" "" "" "" "227.6" "219.4" "242.5" "215.2" "217.5" "225.5" "221.5" "216.8" "315.8" "242.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8273145356875318632" "False" "High" "IsMasterProtein" "Q9BXI6" "TBC1 domain family member 10A OS=Homo sapiens OX=9606 GN=TBC1D10A PE=1 SV=1" "0.000" "False" "7.516" "2" "1" "1" "1" "508" "57.1" "8.44" "4.55" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "83874" "ENSG00000099992" "TBC1D10A" "B3KXT8; hsa:83874; O76053; Q20WK7; Q543A2; Q9BXI6" "TBC/RABGAPs" "Deregulation of Rab and Rab effector genes in bladder cancer" "2" "0" "0.971" "1.035" "0.933" "0.879" "0.878" "1.060" "1.032" "1.135" "1.037" "164.5" "159.7" "170.2" "153.4" "144.6" "144.4" "174.4" "169.8" "186.6" "170.5" "" "" "" "" "" "" "" "" "" "" "132.1" "115.3" "135.2" "102.8" "100.0" "108.3" "122.1" "124.0" "186.6" "138.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "127392206666109507" "False" "High" "IsMasterProtein" "O95166" "Gamma-aminobutyric acid receptor-associated protein OS=Homo sapiens OX=9606 GN=GABARAP PE=1 SV=1" "0.000" "False" "7.513" "15" "3" "5" "1" "117" "13.9" "8.79" "15.90" "3" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11337" "ENSG00000170296" "GABARAP" "hsa:11337; O95166" "Macroautophagy; TBC/RABGAPs" "2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "4" "0" "1.085" "1.012" "1.001" "0.932" "1.041" "1.066" "1.074" "1.018" "0.985" "338.1" "366.9" "342.1" "338.4" "315.1" "352.1" "360.5" "363.0" "344.2" "332.9" "" "" "" "" "" "" "" "" "" "" "271.6" "264.7" "271.8" "226.7" "218.0" "264.2" "252.4" "265.1" "344.2" "270.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5593036104782441701" "False" "High" "IsMasterProtein" "Q8NCF5" "NFATC2-interacting protein OS=Homo sapiens OX=9606 GN=NFATC2IP PE=1 SV=1" "0.000" "False" "7.507" "6" "2" "2" "2" "419" "45.8" "6.60" "5.80" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf11976" "84901" "ENSG00000176953" "NFATC2IP" "B7Z4G5; hsa:84901; Q66K34; Q6NVK1; Q8NCF5; Q8NFR2; Q96ST9" "" "16p11.2 distal deletion syndrome" "1" "0" "1.149" "0.989" "1.405" "1.481" "0.807" "1.088" "1.416" "1.061" "0.845" "18.8" "21.7" "18.6" "26.5" "27.9" "15.2" "20.5" "26.7" "20.0" "15.9" "" "" "" "" "" "" "" "" "" "" "15.1" "15.6" "14.8" "17.7" "19.3" "11.4" "14.4" "19.5" "20.0" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8959015413367013633" "False" "High" "IsMasterProtein" "Q6P589" "Tumor necrosis factor alpha-induced protein 8-like protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP8L2 PE=1 SV=1" "0.000" "False" "7.504" "10" "2" "3" "2" "184" "20.5" "8.44" "6.28" "2" "stress response;other biological processes" "nucleus;other cytoplasmic organelle;other cell component" "" "Pf05527" "79626" "ENSG00000163154" "TNFAIP8L2" "hsa:79626; Q6I9Y0; Q6P589; Q9H2H7; Q9H5G2" "PI Metabolism" "" "1" "0" "0.905" "0.863" "1.029" "0.924" "0.953" "0.916" "0.878" "1.042" "0.897" "250.8" "227.0" "216.6" "258.2" "231.7" "239.0" "229.8" "220.3" "261.5" "225.0" "" "" "" "" "" "" "" "" "" "" "201.5" "163.8" "172.0" "173.0" "160.2" "179.3" "160.9" "160.9" "261.5" "183.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7892576250417935997" "False" "High" "IsMasterProtein" "A6NKD9" "Coiled-coil domain-containing protein 85C OS=Homo sapiens OX=9606 GN=CCDC85C PE=1 SV=1" "0.000" "False" "7.498" "3" "1" "1" "1" "419" "45.2" "6.96" "4.98" "1" "developmental processes" "other cell component" "" "Pf10226" "317762" "ENSG00000205476" "CCDC85C" "A6NKD9; hsa:317762" "" "" "0" "0" "1.061" "1.027" "1.171" "1.002" "1.067" "1.071" "1.077" "1.110" "1.045" "185.3" "196.7" "190.3" "217.0" "185.7" "197.8" "198.4" "199.7" "205.7" "193.8" "" "" "" "" "" "" "" "" "" "" "148.9" "141.9" "151.2" "145.4" "128.5" "148.4" "138.9" "145.8" "205.7" "157.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8757061134285989517" "False" "High" "IsMasterProtein" "Q13586" "Stromal interaction molecule 1 OS=Homo sapiens OX=9606 GN=STIM1 PE=1 SV=3" "0.000" "False" "7.482" "4" "2" "2" "2" "685" "77.4" "6.67" "5.97" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "cytoskeletal activity;other molecular function" "Pf07647, Pf16533" "6786" "ENSG00000167323" "STIM1" "E9PQJ4; hsa:6786; Q13586; Q8N382" "Ion homeostasis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Elevation of cytosolic Ca2+ levels" "CAMKK2 pathway; Affected pathways in Duchenne muscular dystrophy" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8759036951300063870" "False" "High" "IsMasterProtein" "Q6ZT12" "E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens OX=9606 GN=UBR3 PE=1 SV=2" "0.000" "False" "7.470" "1" "2" "2" "2" "1888" "212.3" "6.10" "6.11" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf02207, Pf18995" "130507" "ENSG00000144357" "UBR3" "B4DZR7; Q2KHN5; Q6ZR55; Q6ZSC2; Q6ZT12; Q8IVE7; Q8ND96" "" "" "0" "0" "0.837" "0.880" "1.043" "1.052" "0.847" "1.034" "1.092" "0.991" "1.017" "154.5" "129.4" "136.0" "161.1" "162.5" "130.8" "159.8" "168.7" "153.2" "157.1" "" "" "" "" "" "" "" "" "" "" "124.1" "93.4" "108.0" "107.9" "112.4" "98.1" "111.9" "123.2" "153.2" "127.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "884505446193914017" "False" "High" "IsMasterProtein" "O43752" "Syntaxin-6 OS=Homo sapiens OX=9606 GN=STX6 PE=1 SV=1" "0.000" "False" "7.434" "4" "1" "1" "1" "255" "29.2" "4.93" "4.34" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf09177" "10228" "ENSG00000135823" "STX6" "B2R652; B4DR17; hsa:10228; O43752; Q5VY08; Q6FH83" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "2" "0" "1.042" "0.974" "1.032" "1.055" "0.958" "1.077" "1.026" "1.055" "1.036" "205.6" "214.1" "200.2" "212.1" "216.8" "197.0" "221.4" "211.0" "217.0" "213.0" "" "" "" "" "" "" "" "" "" "" "165.1" "154.5" "159.1" "142.1" "149.9" "147.8" "155.0" "154.1" "217.0" "173.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378984088295691653" "False" "High" "IsMasterProtein" "P49023" "Paxillin OS=Homo sapiens OX=9606 GN=PXN PE=1 SV=3" "0.000" "False" "7.431" "4" "3" "3" "3" "591" "64.5" "6.19" "8.64" "3" "cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00412, Pf03535" "5829" "ENSG00000089159" "PXN" "B2RAI3; B7ZMB4; hsa:5829; O14970; O14971; O60360; P49023; Q5HYA4" "VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton; GDNF signaling; HDAC6 interactions in the central nervous system" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2611611163430655941" "False" "High" "IsMasterProtein" "P01106" "Myc proto-oncogene protein OS=Homo sapiens OX=9606 GN=MYC PE=1 SV=2" "0.000" "False" "7.429" "4" "2" "2" "2" "454" "50.5" "5.43" "5.96" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf01056, Pf02344" "4609" "ENSG00000136997" "MYC" "A0A024R9L7; A0A087WUS5; A8WFE7; H0YBT0; hsa:4609; P01106; P01107; Q14026" "MAPK6/MAPK4 signaling; Ub-specific processing proteases; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by ALK; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of NFE2L2 gene expression; Transcriptional regulation of granulopoiesis; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Binding of TCF/LEF:CTNNB1 to target gene promoters; Cyclin A:Cdk2-associated events at S phase entry; TFAP2 (AP-2) family regulates transcription of cell cycle factors; RUNX3 regulates WNT signaling" "IL-5 signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated cancer pathway; Thyroid stimulating hormone (TSH) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; Metastatic brain tumor; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Gastric cancer network 2; Spinal cord injury; Retinoblastoma gene in cancer; Apoptosis; Polycystic kidney disease pathway; Aryl hydrocarbon receptor pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Mammary gland development pathway - Puberty (Stage 2 of 4); Mammary gland development pathway - Involution (Stage 4 of 4); Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; Ectoderm differentiation; Vitamin D receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; let-7 inhibition of ES cell reprogramming; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; Imatinib and chronic myeloid leukemia; Hepatitis C and hepatocellular carcinoma; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Hippo-Merlin signaling dysregulation; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; 3q29 copy number variation syndrome; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; Orexin receptor pathway; CCL18 signaling pathway; GDNF signaling; Warburg effect modulated by deubiquitinating enzymes and their substrates; Neurogenesis regulation in the olfactory epithelium; Acute myeloid leukemia; Pathophysiological roles of DUX4 in FSHD1; 5q35 copy number variation; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "91" "0" "0.951" "1.010" "0.973" "0.883" "1.014" "0.707" "0.695" "0.744" "0.835" "185.0" "176.0" "186.8" "180.1" "163.5" "187.7" "130.8" "128.6" "137.7" "154.5" "" "" "" "" "" "" "" "" "" "" "148.6" "127.0" "148.4" "120.7" "113.1" "140.8" "91.6" "93.9" "137.7" "125.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2969987479368307007" "False" "High" "IsMasterProtein" "O14657" "Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2" "0.000" "False" "7.424" "3" "1" "1" "1" "336" "38.0" "8.54" "4.87" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;nucleus" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "27348" "ENSG00000136816" "TOR1B" "hsa:27348; O14657" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "0" "1.047" "0.956" "1.071" "1.022" "0.984" "1.009" "1.013" "1.071" "0.977" "211.3" "221.2" "202.0" "226.4" "215.9" "207.9" "213.3" "214.0" "226.4" "206.4" "" "" "" "" "" "" "" "" "" "" "169.7" "159.6" "160.5" "151.7" "149.4" "156.0" "149.4" "156.3" "226.4" "167.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2204752013873116397" "False" "High" "IsMasterProtein" "Q8IV20" "Purine nucleoside phosphorylase LACC1 OS=Homo sapiens OX=9606 GN=LACC1 PE=1 SV=1" "0.000" "False" "7.416" "3" "1" "1" "1" "430" "47.7" "7.06" "4.74" "1" "stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf02578" "144811" "ENSG00000179630" "LACC1" "A2A3Z6; hsa:144811; Q8IV20; Q8N8X5" "" "" "0" "0" "1.126" "0.999" "0.985" "1.179" "1.101" "1.056" "1.001" "1.012" "1.099" "105.8" "119.2" "105.7" "104.3" "124.8" "116.5" "111.8" "105.9" "107.1" "116.3" "" "" "" "" "" "" "" "" "" "" "85.0" "86.0" "84.0" "69.9" "86.3" "87.4" "78.3" "77.3" "107.1" "94.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3656789324422396877" "False" "High" "IsMasterProtein" "P11912" "B-cell antigen receptor complex-associated protein alpha chain OS=Homo sapiens OX=9606 GN=CD79A PE=1 SV=2" "0.000" "False" "7.384" "10" "1" "2" "1" "226" "25.0" "5.00" "8.62" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00047, Pf02189" "973" "ENSG00000105369" "CD79A" "A0N775; hsa:973; P11912; Q53FB8" "CD22 mediated BCR regulation; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "5" "0" "0.906" "0.839" "0.811" "0.874" "0.936" "0.841" "0.895" "0.861" "0.886" "53.2" "48.2" "44.7" "43.2" "46.5" "49.8" "44.8" "47.6" "45.8" "47.2" "" "" "" "" "" "" "" "" "" "" "42.8" "34.8" "35.5" "28.9" "32.2" "37.4" "31.3" "34.8" "45.8" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4095542091731415933" "False" "High" "IsMasterProtein" "Q9HA47" "Uridine-cytidine kinase 1 OS=Homo sapiens OX=9606 GN=UCK1 PE=1 SV=1" "0.000" "False" "7.379" "9" "3" "3" "2" "277" "31.4" "7.30" "5.72" "3" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "83549" "ENSG00000130717" "UCK1" "hsa:83549; Q5JT09; Q5JT10; Q5JT12; Q5JT13; Q6IA74; Q96BJ0; Q9HA47" "Pyrimidine salvage" "Fluoropyrimidine activity; Pyrimidine metabolism; IL-18 signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1533138465656150959" "False" "High" "IsMasterProtein" "Q5VWQ0" "Lysine-specific demethylase 9 OS=Homo sapiens OX=9606 GN=RSBN1 PE=1 SV=2" "0.000" "False" "7.367" "3" "2" "3" "2" "802" "90.0" "8.60" "4.24" "2" "cell organization and biogenesis" "nucleus" "other molecular function" "" "54665" "ENSG00000081019" "RSBN1" "A8K937; hsa:54665; Q5VWQ0; Q6AI21; Q8TC33; Q9HA80; Q9NUP6" "" "" "0" "0" "0.915" "0.939" "0.965" "0.957" "0.917" "1.004" "0.907" "0.959" "0.995" "222.5" "203.6" "208.9" "214.7" "212.9" "204.1" "223.5" "201.8" "213.4" "221.3" "" "" "" "" "" "" "" "" "" "" "178.7" "146.9" "165.9" "143.9" "147.2" "153.1" "156.5" "147.4" "213.4" "179.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5249923035871806906" "False" "High" "IsMasterProtein" "O60759" "Cytohesin-interacting protein OS=Homo sapiens OX=9606 GN=CYTIP PE=1 SV=2" "0.000" "False" "7.361" "6" "3" "3" "2" "359" "40.0" "6.99" "7.21" "3" "other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00595" "9595" "ENSG00000115165" "CYTIP" "B4DWH9; hsa:9595; O60759; Q15630; Q8NE32" "" "Amplification and expansion of oncogenic pathways as metastatic traits" "1" "0" "0.965" "0.977" "1.013" "0.903" "0.967" "1.136" "1.044" "1.105" "1.136" "84.2" "81.3" "82.2" "85.3" "76.0" "81.4" "95.7" "87.9" "93.0" "95.7" "" "" "" "" "" "" "" "" "" "" "67.6" "58.6" "65.3" "57.2" "52.6" "61.1" "67.0" "64.2" "93.0" "77.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421989768094974956" "False" "High" "IsMasterProtein" "Q96BM9" "ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1" "0.000" "False" "7.360" "13" "2" "2" "2" "186" "21.4" "7.77" "5.19" "2" "cell cycle OR cell proliferation;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "127829" "ENSG00000143862" "ARL8A" "B3KXD0; hsa:127829; Q96BM9" "Neutrophil degranulation" "" "1" "0" "1.499" "1.300" "1.524" "1.517" "1.237" "1.627" "1.246" "1.157" "1.301" "50.0" "75.0" "65.0" "76.2" "75.8" "61.9" "81.3" "62.3" "57.9" "65.1" "" "" "" "" "" "" "" "" "" "" "40.2" "54.1" "51.6" "51.1" "52.5" "46.4" "57.0" "45.5" "57.9" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5539226776075582677" "False" "High" "IsMasterProtein" "Q5TC82" "Roquin-1 OS=Homo sapiens OX=9606 GN=RC3H1 PE=1 SV=1" "0.000" "False" "7.356" "3" "3" "3" "3" "1133" "125.7" "7.27" "8.48" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf14634, Pf18386, Pf21206" "149041" "ENSG00000135870" "RC3H1" "B3KVK1; hsa:149041; Q5TC82; Q5W180; Q5W181; Q8IVE6; Q8N9V1" "" "" "0" "0" "1.164" "1.105" "1.082" "1.170" "1.195" "1.078" "1.023" "1.158" "1.132" "176.1" "205.0" "194.5" "190.5" "206.0" "210.5" "189.8" "180.2" "203.9" "199.3" "" "" "" "" "" "" "" "" "" "" "141.4" "147.9" "154.5" "127.7" "142.5" "157.9" "132.9" "131.6" "203.9" "162.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6591516084365101626" "False" "High" "IsMasterProtein" "Q9H5X1" "Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1" "0.000" "False" "7.352" "13" "2" "3" "2" "160" "18.3" "4.88" "9.57" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01883" "84191" "ENSG00000166797" "CIAO2A" "A6NKS1; B2R5F8; B7Z8Z5; hsa:84191; Q9H5X1" "" "2q11.2 copy number variation syndrome" "1" "0" "1.080" "1.174" "1.268" "1.098" "1.183" "1.070" "1.138" "1.142" "1.120" "79.2" "85.6" "93.1" "100.5" "87.0" "93.8" "84.8" "90.2" "90.5" "88.7" "" "" "" "" "" "" "" "" "" "" "63.6" "61.8" "73.9" "67.3" "60.2" "70.4" "59.4" "65.9" "90.5" "72.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981490796003058050" "False" "High" "IsMasterProtein" "Q9H4P4" "E3 ubiquitin-protein ligase NRDP1 OS=Homo sapiens OX=9606 GN=RNF41 PE=1 SV=2" "0.000" "False" "7.349" "10" "2" "3" "2" "317" "35.9" "6.14" "5.40" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08941, Pf13923" "10193" "ENSG00000181852" "RNF41" "A6NFW0; B2RBT8; hsa:10193; O75598; Q9H4P4" "Antigen processing: Ubiquitination & Proteasome degradation; Downregulation of ERBB2:ERBB3 signaling" "" "2" "0" "0.890" "0.981" "1.063" "0.957" "0.811" "0.856" "0.936" "1.021" "0.893" "112.5" "100.0" "110.3" "119.5" "107.6" "91.2" "96.2" "105.2" "114.8" "100.5" "" "" "" "" "" "" "" "" "" "" "90.3" "72.2" "87.6" "80.1" "74.4" "68.4" "67.4" "76.8" "114.8" "81.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262786275028472849" "False" "High" "IsMasterProtein" "Q9Y421" "Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2" "0.000" "False" "7.346" "24" "3" "5" "3" "112" "13.2" "9.99" "12.88" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf08555" "26017" "ENSG00000105058" "FAM32A" "hsa:26017; Q9BT02; Q9Y421" "mRNA Splicing - Major Pathway" "" "1" "0" "1.071" "1.092" "1.085" "1.075" "1.101" "0.995" "1.022" "1.128" "1.103" "632.7" "677.5" "691.2" "686.2" "679.9" "696.6" "629.4" "646.9" "714.0" "697.6" "" "" "" "" "" "" "" "" "" "" "508.2" "488.9" "549.0" "459.8" "470.2" "522.6" "440.7" "472.4" "714.0" "567.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5102394332226681343" "False" "High" "IsMasterProtein" "Q05932" "Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=FPGS PE=1 SV=3" "0.000" "False" "7.343" "3" "2" "2" "2" "587" "64.6" "7.94" "7.47" "2" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "" "2356" "ENSG00000136877" "FPGS" "B3KPW4; B7Z2Z3; F5H0K6; hsa:2356; Q05932; Q5JU19; Q5JU22; Q6P2P6" "" "Fluoropyrimidine activity" "1" "0" "0.932" "0.939" "0.946" "0.979" "0.834" "0.994" "0.828" "0.959" "0.885" "44.1" "41.1" "41.4" "41.7" "43.2" "36.8" "43.8" "36.5" "42.3" "39.0" "" "" "" "" "" "" "" "" "" "" "35.4" "29.7" "32.9" "28.0" "29.9" "27.6" "30.7" "26.7" "42.3" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660069339337031106" "False" "High" "IsMasterProtein" "Q5T1R4" "Transcription factor HIVEP3 OS=Homo sapiens OX=9606 GN=HIVEP3 PE=1 SV=1" "0.000" "False" "7.339" "1" "2" "2" "2" "2406" "259.3" "7.81" "5.51" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "59269" "ENSG00000127124" "HIVEP3" "A7YY91; hsa:59269; Q5T1R4; Q5T1R5; Q9BZS0; Q9HCL7" "Regulation of RUNX2 expression and activity" "" "1" "0" "1.196" "1.375" "1.216" "1.174" "1.488" "1.296" "1.356" "1.627" "1.560" "19.4" "23.3" "26.7" "23.7" "22.8" "28.9" "25.2" "26.4" "31.6" "30.3" "" "" "" "" "" "" "" "" "" "" "15.6" "16.8" "21.2" "15.9" "15.8" "21.7" "17.6" "19.3" "31.6" "24.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1899835700088576048" "False" "High" "IsMasterProtein" "O14656" "Torsin-1A OS=Homo sapiens OX=9606 GN=TOR1A PE=1 SV=1" "0.000" "False" "7.335" "3" "1" "2" "1" "332" "37.8" "6.99" "7.54" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "1861" "ENSG00000136827" "TOR1A" "B2RB58; hsa:1861; O14656; Q53Y64; Q96CA0" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "0" "1.220" "0.986" "1.144" "1.271" "1.110" "1.147" "0.918" "1.131" "1.069" "125.4" "153.0" "123.7" "143.5" "159.4" "139.2" "143.8" "115.1" "141.8" "134.1" "" "" "" "" "" "" "" "" "" "" "100.7" "110.4" "98.2" "96.1" "110.2" "104.5" "100.7" "84.1" "141.8" "109.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7135249905505884321" "False" "High" "IsMasterProtein" "P0DTL6" "Zinc finger TRAF-type-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFTRAF1 PE=1 SV=1" "0.000" "False" "7.326" "6" "3" "3" "3" "404" "43.8" "6.76" "8.46" "3" "" "nucleus;other cell component" "other molecular function" "" "157542; 50626; 84773" "ENSG00000187954" "ZFTRAF1" "B3KSX0; D3DWM3; E9PJD7; hsa:157542; hsa:50626; hsa:84773; P0DTL6; Q6ZMK1; Q9BSF6; Q9BSU6" "" "" "0" "0" "1.271" "0.939" "1.212" "1.231" "1.109" "1.178" "1.019" "1.049" "1.094" "121.9" "155.0" "114.5" "147.8" "150.2" "135.3" "143.7" "124.2" "127.9" "133.4" "" "" "" "" "" "" "" "" "" "" "97.9" "111.9" "91.0" "99.0" "103.9" "101.5" "100.6" "90.7" "127.9" "108.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2137226823831967498" "False" "High" "IsMasterProtein" "Q0VD83" "Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3" "0.000" "False" "7.322" "1" "1" "1" "1" "1097" "115.6" "4.40" "3.94" "1" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "" "55911" "ENSG00000184730" "APOBR" "H3BU97; hsa:55911; Q0VD81; Q0VD83; Q8NC15; Q9NPJ9" "VLDL clearance" "" "1" "0" "1.154" "1.030" "1.245" "1.183" "1.017" "1.153" "1.191" "1.020" "1.049" "26.9" "31.0" "27.7" "33.4" "31.8" "27.3" "31.0" "32.0" "27.4" "28.2" "" "" "" "" "" "" "" "" "" "" "21.6" "22.4" "22.0" "22.4" "22.0" "20.5" "21.7" "23.4" "27.4" "22.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2814328454838082789" "False" "High" "IsMasterProtein" "Q6P087" "Mitochondrial mRNA pseudouridine synthase RPUSD3 OS=Homo sapiens OX=9606 GN=RPUSD3 PE=1 SV=3" "0.000" "False" "7.321" "7" "3" "3" "3" "351" "38.4" "10.32" "8.93" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00849" "285367" "ENSG00000156990" "RPUSD3" "B4DS39; hsa:285367; Q6P087; Q6P6A9; Q8N1B2; Q8NAV3" "" "" "0" "0" "1.019" "0.940" "1.003" "1.026" "1.023" "0.974" "0.930" "0.962" "1.016" "205.5" "209.5" "193.3" "206.2" "211.0" "210.2" "200.2" "191.2" "197.6" "208.8" "" "" "" "" "" "" "" "" "" "" "165.1" "151.2" "153.5" "138.1" "145.9" "157.7" "140.2" "139.6" "197.6" "169.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115267819831113520" "False" "High" "IsMasterProtein" "Q8IX18" "Probable ATP-dependent RNA helicase DHX40 OS=Homo sapiens OX=9606 GN=DHX40 PE=1 SV=2" "0.000" "False" "7.318" "3" "2" "2" "2" "779" "88.5" "8.65" "7.28" "2" "" "" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "79665" "ENSG00000108406" "DHX40" "B3KTJ5; C9JR60; hsa:79665; Q5JPH4; Q8IX18; Q8TC86; Q8WY53; Q9BXM1; Q9H6M9" "" "" "0" "0" "0.798" "0.868" "1.021" "0.926" "0.973" "0.879" "0.730" "1.125" "0.985" "51.2" "40.8" "44.4" "52.2" "47.4" "49.8" "45.0" "37.3" "57.5" "50.4" "" "" "" "" "" "" "" "" "" "" "41.1" "29.5" "35.3" "35.0" "32.8" "37.4" "31.5" "27.3" "57.5" "41.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5420555494446778238" "False" "High" "IsMasterProtein" "P15907" "Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Homo sapiens OX=9606 GN=ST6GAL1 PE=1 SV=1" "0.000" "False" "7.317" "4" "2" "2" "2" "406" "46.6" "9.01" "6.38" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "other molecular function" "Pf00777" "6480" "ENSG00000073849" "ST6GAL1" "A8KA14; B2R513; D3DNV3; hsa:6480; P15907" "Sialic acid metabolism; N-Glycan antennae elongation; Maturation of spike protein; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis" "N-glycan biosynthesis" "7" "0" "0.946" "0.916" "0.981" "0.992" "1.151" "0.941" "1.046" "1.085" "1.056" "336.5" "318.4" "308.2" "330.2" "333.9" "387.3" "316.5" "351.9" "365.0" "355.4" "" "" "" "" "" "" "" "" "" "" "270.2" "229.8" "244.8" "221.2" "230.9" "290.6" "221.6" "257.0" "365.0" "289.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8281195296370466031" "False" "High" "IsMasterProtein" "P0CG13" "Chromosome transmission fidelity protein 8 homolog OS=Homo sapiens OX=9606 GN=CHTF8 PE=1 SV=1" "0.000" "False" "7.313" "17" "2" "2" "2" "121" "13.3" "8.18" "6.63" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf09696" "54921" "ENSG00000168802" "CHTF8" "A8MYX8; hsa:54921; P0CG13; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "Polymerase switching on the C-strand of the telomere" "Gastric cancer network 2" "2" "0" "0.934" "1.037" "1.214" "0.760" "1.072" "0.924" "0.881" "1.070" "1.175" "34.5" "32.2" "35.7" "41.8" "26.2" "36.9" "31.9" "30.4" "36.9" "40.5" "" "" "" "" "" "" "" "" "" "" "27.7" "23.2" "28.4" "28.0" "18.1" "27.7" "22.3" "22.2" "36.9" "32.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8127793230594197368" "False" "High" "IsMasterProtein" "Q9ULH1" "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4" "0.000" "False" "7.308" "3" "3" "3" "3" "1129" "125.4" "7.31" "8.49" "3" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf14604, Pf16746" "50807" "ENSG00000153317" "ASAP1" "B2RNV3; hsa:50807; Q9ULH1" "VxPx cargo-targeting to cilium" "EGF/EGFR signaling pathway; CCL18 signaling pathway" "3" "0" "0.953" "1.060" "1.042" "1.051" "0.982" "0.940" "1.076" "1.115" "1.052" "163.8" "156.2" "173.6" "170.7" "172.1" "160.9" "154.0" "176.2" "182.6" "172.2" "" "" "" "" "" "" "" "" "" "" "131.5" "112.7" "137.9" "114.3" "119.0" "120.7" "107.8" "128.7" "182.6" "140.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251219974824346079" "False" "High" "IsMasterProtein" "Q05D32" "CTD small phosphatase-like protein 2 OS=Homo sapiens OX=9606 GN=CTDSPL2 PE=1 SV=2" "0.000" "False" "7.306" "3" "1" "1" "1" "466" "53.0" "6.40" "3.89" "1" "transport;other biological processes" "nucleus" "other molecular function" "Pf03031" "51496" "ENSG00000137770" "CTDSPL2" "hsa:51496; Q05D32; Q3ZTU1; Q6AI06; Q8IYI9; Q9NVT2; Q9NZX8; Q9P030" "" "" "0" "0" "1.142" "1.275" "1.146" "1.349" "1.219" "1.529" "1.358" "1.406" "1.328" "40.7" "46.5" "52.0" "46.7" "55.0" "49.7" "62.3" "55.3" "57.3" "54.1" "" "" "" "" "" "" "" "" "" "" "32.7" "33.6" "41.3" "31.3" "38.0" "37.3" "43.6" "40.4" "57.3" "44.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2182760318696824759" "False" "High" "IsMasterProtein" "Q8IWP9" "Coiled-coil domain-containing protein 28A OS=Homo sapiens OX=9606 GN=CCDC28A PE=1 SV=1" "0.000" "False" "7.306" "6" "1" "1" "1" "274" "30.3" "9.25" "3.97" "1" "" "" "" "Pf13270" "25901" "" "CCDC28A" "E1P591; Q32NC7; Q66K67; Q8IWP9; Q96E23; Q9Y430" "" "" "0" "0" "1.149" "0.999" "1.068" "1.076" "1.134" "1.056" "1.279" "1.167" "1.103" "51.2" "58.8" "51.1" "54.7" "55.1" "58.1" "54.0" "65.5" "59.8" "56.5" "" "" "" "" "" "" "" "" "" "" "41.1" "42.5" "40.6" "36.6" "38.1" "43.6" "37.8" "47.8" "59.8" "45.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1820553366353762966" "False" "High" "IsMasterProtein" "Q9UKF7" "Cytoplasmic phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNC1 PE=1 SV=3" "0.000" "False" "7.302" "5" "1" "1" "1" "332" "38.4" "6.40" "3.56" "1" "cell organization and biogenesis;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "26207" "ENSG00000154217" "PITPNC1" "A8K473; hsa:26207; J3QR20; Q96I07; Q9UKF7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3032211375385727038" "False" "High" "IsMasterProtein" "Q15388" "Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1" "0.000" "False" "7.300" "14" "2" "2" "2" "145" "16.3" "8.60" "6.56" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf02064" "9804" "ENSG00000173726" "TOMM20" "A8K195; hsa:9804; Q15388; Q498B3; Q6IBT4" "Ub-specific processing proteases; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "" "3" "0" "0.984" "0.883" "1.035" "1.080" "1.106" "0.998" "0.987" "0.956" "0.834" "159.3" "156.8" "140.6" "165.0" "172.1" "176.3" "159.1" "157.2" "152.2" "132.8" "" "" "" "" "" "" "" "" "" "" "128.0" "113.2" "111.7" "110.5" "119.0" "132.2" "111.4" "114.8" "152.2" "108.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1542361950198791017" "False" "High" "IsMasterProtein" "Q96T21" "Selenocysteine insertion sequence-binding protein 2 OS=Homo sapiens OX=9606 GN=SECISBP2 PE=1 SV=2" "0.000" "False" "7.300" "3" "2" "2" "2" "854" "95.4" "8.12" "6.60" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "79048" "ENSG00000187742" "SECISBP2" "F8W892; hsa:79048; Q5HYY1; Q7L1Z0; Q8IYC0; Q96T21; Q9H0A1" "Selenocysteine synthesis" "" "1" "0" "1.107" "1.006" "1.077" "1.173" "0.983" "1.083" "0.949" "0.886" "1.051" "64.6" "71.5" "65.0" "69.6" "75.8" "63.5" "70.0" "61.3" "57.2" "67.9" "" "" "" "" "" "" "" "" "" "" "51.9" "51.6" "51.6" "46.6" "52.4" "47.6" "49.0" "44.8" "57.2" "55.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980911746470048228" "False" "High" "IsMasterProtein" "P40337" "von Hippel-Lindau disease tumor suppressor OS=Homo sapiens OX=9606 GN=VHL PE=1 SV=2" "0.000" "False" "7.289" "7" "1" "1" "1" "213" "24.1" "4.73" "4.19" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01847, Pf17211" "7428" "ENSG00000134086" "VHL" "B2RE45; hsa:7428; P40337; Q13599; Q6PDA9" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; SUMOylation of ubiquitinylation proteins; RHOBTB3 ATPase cycle; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "Amplification and expansion of oncogenic pathways as metastatic traits; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Orexin receptor pathway; Warburg effect modulated by deubiquitinating enzymes and their substrates; HDAC6 interactions in the central nervous system" "13" "0" "1.060" "1.074" "1.047" "1.119" "1.263" "1.180" "1.049" "1.144" "1.188" "159.0" "168.6" "170.8" "166.5" "178.0" "200.9" "187.7" "166.9" "182.0" "188.9" "" "" "" "" "" "" "" "" "" "" "127.7" "121.6" "135.7" "111.6" "123.1" "150.7" "131.4" "121.9" "182.0" "153.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058846499056220573" "False" "High" "IsMasterProtein" "Q96CP2" "FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1" "0.000" "False" "7.285" "16" "2" "2" "2" "140" "14.6" "8.46" "7.10" "2" "" "" "" "Pf15423" "114984" "ENSG00000162076" "FLYWCH2" "hsa:114984; Q96CP2" "" "" "0" "0" "1.221" "0.945" "1.051" "1.144" "1.098" "1.091" "1.401" "1.008" "1.095" "130.2" "159.0" "123.1" "136.8" "148.9" "143.0" "142.0" "182.5" "131.2" "142.6" "" "" "" "" "" "" "" "" "" "" "104.6" "114.8" "97.8" "91.7" "103.0" "107.3" "99.4" "133.3" "131.2" "116.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629831506614287225" "False" "High" "IsMasterProtein" "Q96A47" "Insulin gene enhancer protein ISL-2 OS=Homo sapiens OX=9606 GN=ISL2 PE=1 SV=1" "0.000" "False" "7.274" "5" "2" "2" "2" "359" "39.7" "8.28" "6.73" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00412" "64843" "ENSG00000159556" "ISL2" "B3KM37; hsa:64843; Q96A47" "" "" "0" "0" "0.941" "1.069" "0.990" "0.867" "1.124" "1.055" "0.898" "0.942" "0.979" "149.5" "140.6" "159.9" "148.0" "129.6" "168.1" "157.7" "134.3" "140.8" "146.4" "" "" "" "" "" "" "" "" "" "" "120.1" "101.5" "127.0" "99.2" "89.6" "126.1" "110.4" "98.1" "140.8" "119.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3651526396460300245" "False" "High" "IsMasterProtein" "P17693" "HLA class I histocompatibility antigen, alpha chain G OS=Homo sapiens OX=9606 GN=HLA-G PE=1 SV=1" "0.000" "False" "7.261" "5" "2" "2" "1" "338" "38.2" "5.69" "5.98" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf07654" "3135" "ENSG00000204632; ENSG00000206506; ENSG00000230413; ENSG00000233095; ENSG00000235346; ENSG00000235680; ENSG00000237216; ENSG00000276051" "HLA-G" "hsa:3135; P17693" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome" "11" "1" "1.116" "1.136" "1.158" "1.136" "1.242" "1.213" "1.103" "1.217" "1.232" "294.2" "328.3" "334.2" "340.7" "334.2" "365.4" "356.8" "324.5" "357.9" "362.4" "" "" "" "" "" "" "" "" "" "" "236.3" "236.9" "265.4" "228.3" "231.1" "274.2" "249.8" "237.0" "357.9" "294.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2207555378581959897" "False" "High" "IsMasterProtein" "Q14761" "Protein tyrosine phosphatase receptor type C-associated protein OS=Homo sapiens OX=9606 GN=PTPRCAP PE=1 SV=1" "0.000" "False" "7.255" "12" "2" "2" "2" "206" "21.2" "4.55" "4.75" "2" "stress response" "plasma membrane;other membranes" "" "Pf15713" "5790" "ENSG00000213402" "PTPRCAP" "B2R512; hsa:5790; O00643; Q14761; Q6I9S6" "" "TNF-alpha signaling pathway" "1" "0" "0.986" "0.855" "1.234" "1.091" "1.009" "1.238" "1.168" "1.017" "1.150" "126.4" "124.7" "108.1" "156.0" "137.9" "127.5" "156.5" "147.7" "128.6" "145.4" "" "" "" "" "" "" "" "" "" "" "101.5" "90.0" "85.9" "104.5" "95.4" "95.7" "109.6" "107.9" "128.6" "118.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9201189030336339183" "False" "High" "IsMasterProtein" "P62875" "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" "0.000" "False" "7.250" "13" "1" "2" "1" "67" "7.6" "7.77" "5.75" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01194" "5441" "ENSG00000177700" "POLR2L" "hsa:5441; P52436; P62875; Q6FHX3" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "56" "0" "1.217" "1.338" "1.114" "1.087" "1.162" "0.942" "0.837" "1.237" "0.984" "58.5" "71.1" "78.2" "65.2" "63.5" "67.9" "55.1" "48.9" "72.3" "57.5" "" "" "" "" "" "" "" "" "" "" "47.0" "51.3" "62.1" "43.7" "43.9" "51.0" "38.6" "35.7" "72.3" "46.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4904792924861238037" "False" "High" "IsMasterProtein" "Q9Y5J6" "Mitochondrial import inner membrane translocase subunit Tim10 B OS=Homo sapiens OX=9606 GN=TIMM10B PE=1 SV=1" "0.000" "False" "7.227" "24" "1" "1" "1" "103" "11.6" "7.43" "4.99" "1" "cell adhesion;cell organization and biogenesis;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26515" "ENSG00000132286" "TIMM10B" "hsa:26515; Q96FF3; Q9Y5J6" "Mitochondrial protein import" "" "1" "0" "1.617" "0.999" "1.438" "1.982" "1.674" "1.505" "1.059" "1.054" "1.523" "39.2" "63.3" "39.1" "56.3" "77.6" "65.6" "58.9" "41.5" "41.3" "59.6" "" "" "" "" "" "" "" "" "" "" "31.5" "45.7" "31.1" "37.7" "53.7" "49.2" "41.3" "30.3" "41.3" "48.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3423051625263553233" "False" "High" "IsMasterProtein" "Q9BZQ6" "ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens OX=9606 GN=EDEM3 PE=1 SV=2" "0.000" "False" "7.226" "2" "2" "2" "2" "932" "104.6" "4.93" "6.40" "2" "protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi" "other molecular function" "Pf01532, Pf02225" "80267" "ENSG00000116406" "EDEM3" "B2RCH6; B7ZLZ2; hsa:80267; Q0VGM5; Q5TEZ0; Q7L2Y5; Q9BZQ6; Q9HCW1; Q9UFV7" "ER Quality Control Compartment (ERQC)" "" "1" "0" "1.026" "0.892" "0.870" "0.947" "0.949" "1.145" "0.857" "0.906" "0.974" "97.0" "99.5" "86.5" "84.4" "91.9" "92.1" "111.1" "83.2" "87.9" "94.6" "" "" "" "" "" "" "" "" "" "" "77.9" "71.8" "68.7" "56.6" "63.5" "69.1" "77.8" "60.7" "87.9" "76.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4119933875415276465" "False" "High" "IsMasterProtein" "P07902" "Galactose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=GALT PE=1 SV=3" "0.000" "False" "7.225" "4" "1" "1" "1" "379" "43.3" "6.99" "3.86" "1" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01087, Pf02744" "2592" "ENSG00000213930" "GALT" "B4E097; E7ET32; hsa:2592; P07902; Q14355; Q14356; Q14357; Q14358; Q14359; Q14360; Q14361; Q14363; Q14364; Q14365; Q14369; Q14370; Q14371; Q14372; Q14373; Q14374; Q14375; Q14377; Q14378; Q14380; Q14381; Q14382; Q14383; Q14384; Q14385; Q14386; Q14387; Q14389; Q16766; Q53XK1; Q5VZ81; Q96BY1" "Defective GALT can cause GALCT; Galactose catabolism" "Disorders of galactose metabolism ; Primary ovarian insufficiency" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890880560088896106" "False" "High" "IsMasterProtein" "Q8NFZ5" "TNFAIP3-interacting protein 2 OS=Homo sapiens OX=9606 GN=TNIP2 PE=1 SV=1" "0.000" "False" "7.212" "7" "3" "3" "3" "429" "48.7" "6.44" "7.34" "3" "stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12180" "79155" "ENSG00000168884" "TNIP2" "B1AKS4; B3KTY8; D3DVQ9; hsa:79155; Q7L5L2; Q8NFZ5; Q9BQR6; Q9H682" "MAP3K8 (TPL2)-dependent MAPK1/3 activation; Ovarian tumor domain proteases" "RAC1/PAK1/p38/MMP2 pathway" "3" "0" "0.974" "1.005" "1.023" "1.062" "0.981" "1.098" "0.962" "0.921" "1.051" "119.7" "116.6" "120.4" "122.5" "127.1" "117.5" "131.5" "115.2" "110.3" "125.8" "" "" "" "" "" "" "" "" "" "" "96.2" "84.2" "95.6" "82.1" "87.9" "88.2" "92.1" "84.1" "110.3" "102.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6229866583710047273" "False" "High" "IsMasterProtein" "Q96C23" "Galactose mutarotase OS=Homo sapiens OX=9606 GN=GALM PE=1 SV=1" "0.000" "False" "7.196" "5" "2" "2" "2" "342" "37.7" "6.65" "7.23" "2" "other metabolic processes" "other cell component" "other molecular function" "Pf01263" "130589" "ENSG00000143891" "GALM" "hsa:130589; Q53RY1; Q8NIA2; Q96C23; V9HWA8" "" "" "0" "0" "0.971" "1.131" "1.174" "0.951" "1.085" "0.998" "1.021" "0.995" "1.113" "190.1" "184.5" "215.0" "223.2" "180.8" "206.2" "189.6" "194.1" "189.2" "211.6" "" "" "" "" "" "" "" "" "" "" "152.7" "133.2" "170.8" "149.5" "125.0" "154.7" "132.8" "141.8" "189.2" "172.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2313523377555804982" "False" "High" "IsMasterProtein" "P49754" "Vacuolar protein sorting-associated protein 41 homolog OS=Homo sapiens OX=9606 GN=VPS41 PE=1 SV=3" "0.000" "False" "7.190" "3" "3" "3" "3" "854" "98.5" "5.85" "7.86" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00637" "27072" "ENSG00000006715" "VPS41" "E9PF36; hsa:27072; P49754; Q86TP8; Q99851; Q99852" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "3" "0" "0.867" "1.062" "0.967" "0.963" "1.021" "1.049" "1.108" "0.942" "0.977" "117.1" "101.6" "124.4" "113.3" "112.7" "119.6" "122.8" "129.8" "110.3" "114.4" "" "" "" "" "" "" "" "" "" "" "94.0" "73.3" "98.8" "75.9" "78.0" "89.7" "86.0" "94.8" "110.3" "93.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2567249118239018231" "False" "High" "IsMasterProtein" "Q9C0B5" "Palmitoyltransferase ZDHHC5 OS=Homo sapiens OX=9606 GN=ZDHHC5 PE=1 SV=2" "0.000" "False" "7.188" "3" "2" "3" "2" "715" "77.5" "9.01" "6.39" "2" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01529" "25921" "ENSG00000156599" "ZDHHC5" "hsa:25921; Q2TGF0; Q6ZMF0; Q8TAK8; Q9C0B5; Q9H923; Q9UFI7" "Maturation of spike protein" "" "1" "0" "1.056" "0.808" "1.127" "1.010" "0.915" "1.107" "0.978" "1.088" "1.023" "121.7" "128.6" "98.3" "137.2" "122.9" "111.4" "134.7" "119.0" "132.5" "124.6" "" "" "" "" "" "" "" "" "" "" "97.8" "92.8" "78.1" "91.9" "85.0" "83.6" "94.3" "86.9" "132.5" "101.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6742852748718514875" "False" "High" "IsMasterProtein" "Q6PH85" "DCN1-like protein 2 OS=Homo sapiens OX=9606 GN=DCUN1D2 PE=1 SV=1" "0.000" "False" "7.184" "7" "2" "3" "1" "259" "30.2" "6.00" "9.39" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "55208" "ENSG00000150401" "DCUN1D2" "hsa:55208; Q5JSA5; Q5JSA6; Q5JSA7; Q6PH85; Q9NVJ1; Q9NXR6" "Neddylation" "" "1" "0" "1.068" "1.116" "1.102" "1.268" "0.940" "1.181" "1.095" "1.153" "1.065" "165.7" "177.0" "185.0" "182.6" "210.2" "155.8" "195.7" "181.4" "191.0" "176.5" "" "" "" "" "" "" "" "" "" "" "133.1" "127.7" "147.0" "122.4" "145.4" "116.9" "137.0" "132.5" "191.0" "143.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991903496179440797" "False" "High" "IsMasterProtein" "A8CG34" "Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3" "0.000" "False" "7.182" "1" "1" "1" "1" "1229" "125.0" "10.37" "4.68" "1" "transport" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf15229" "" "ENSG00000272391" "POM121C" "A0A075B7F8; A0A087WY75; A8CG34; O75115; Q9Y2N3; Q9Y4S7" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2457834817562912062" "False" "High" "IsMasterProtein" "Q9GZY8" "Mitochondrial fission factor OS=Homo sapiens OX=9606 GN=MFF PE=1 SV=1" "0.000" "False" "7.176" "4" "1" "3" "1" "342" "38.4" "8.95" "9.67" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05644" "56947" "ENSG00000168958" "MFF" "hsa:56947; Q567U1; Q658R6; Q9BVZ1; Q9GZY8; Q9H690; Q9NRG8" "" "" "0" "0" "1.084" "0.995" "1.066" "1.130" "1.018" "1.032" "1.045" "1.077" "1.051" "392.0" "425.0" "389.9" "418.0" "442.9" "399.1" "404.6" "409.5" "422.2" "412.0" "" "" "" "" "" "" "" "" "" "" "314.9" "306.7" "309.7" "280.0" "306.3" "299.4" "283.3" "299.0" "422.2" "335.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779198879907914861" "False" "High" "IsMasterProtein" "P62328" "Thymosin beta-4 OS=Homo sapiens OX=9606 GN=TMSB4X PE=1 SV=2" "0.000" "True" "7.164" "32" "2" "12" "2" "44" "5.1" "5.06" "33.74" "2" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01290" "7114" "ENSG00000205542" "TMSB4X" "hsa:7114; P01253; P01254; P62328; Q546P5; Q63576; Q9UE55" "Platelet degranulation" "Genes targeted by miRNAs in adipocytes; VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Regulation of actin cytoskeleton" "5" "0" "1.113" "1.255" "1.111" "1.241" "0.752" "1.022" "1.286" "1.385" "1.080" "1464.1" "1630.0" "1837.1" "1626.5" "1816.9" "1100.8" "1496.4" "1883.2" "2028.4" "1581.8" "" "" "" "" "" "" "" "" "" "" "1176.0" "1176.2" "1459.3" "1089.7" "1256.6" "825.9" "1047.7" "1375.3" "2028.4" "1286.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "121458031031999340" "False" "High" "IsMasterProtein" "P35232" "Prohibitin 1 OS=Homo sapiens OX=9606 GN=PHB1 PE=1 SV=1" "0.000" "False" "7.157" "7" "2" "2" "2" "272" "29.8" "5.76" "6.38" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "5245" "ENSG00000167085" "PHB1" "B4DY47; hsa:5245; P35232; Q4VBQ0" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Processing of SMDT1" "" "5" "0" "1.077" "1.184" "1.706" "1.333" "1.200" "1.590" "0.986" "1.356" "1.226" "207.7" "223.6" "245.9" "354.3" "276.8" "249.2" "330.2" "204.9" "281.6" "254.7" "" "" "" "" "" "" "" "" "" "" "166.8" "161.3" "195.3" "237.4" "191.4" "187.0" "231.2" "149.6" "281.6" "207.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1292677114640833852" "False" "High" "IsMasterProtein" "Q5VZL5" "Zinc finger MYM-type protein 4 OS=Homo sapiens OX=9606 GN=ZMYM4 PE=1 SV=1" "0.000" "False" "7.151" "2" "3" "3" "3" "1548" "172.7" "6.84" "6.08" "3" "cell organization and biogenesis;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9202" "ENSG00000146463" "ZMYM4" "A0JP19; A0JP20; hsa:9202; O43308; Q5T5E1; Q5T5E2; Q5VZL5; Q7L3Q4" "" "" "0" "0" "1.037" "0.950" "1.208" "0.943" "1.029" "1.071" "0.803" "0.878" "1.024" "126.3" "131.0" "119.9" "152.5" "119.1" "129.9" "135.3" "101.4" "110.9" "129.2" "" "" "" "" "" "" "" "" "" "" "101.4" "94.5" "95.3" "102.2" "82.4" "97.5" "94.7" "74.1" "110.9" "105.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9109168455093907053" "False" "High" "IsMasterProtein" "Q92622" "Run domain Beclin-1-interacting and cysteine-rich domain-containing protein OS=Homo sapiens OX=9606 GN=RUBCN PE=1 SV=4" "0.000" "False" "7.146" "2" "2" "2" "2" "972" "108.6" "6.25" "6.79" "2" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02759, Pf13901, Pf21054" "9711" "ENSG00000145016" "RUBCN" "hsa:9711; Q92622; Q96CK5" "" "" "0" "0" "1.037" "1.043" "1.032" "0.957" "1.051" "1.073" "1.062" "1.070" "1.002" "237.3" "246.2" "247.5" "244.9" "227.1" "249.4" "254.6" "251.9" "253.8" "237.9" "" "" "" "" "" "" "" "" "" "" "190.6" "177.6" "196.6" "164.1" "157.1" "187.1" "178.3" "184.0" "253.8" "193.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2059779998353867711" "False" "High" "IsMasterProtein" "Q58A45" "PAN2-PAN3 deadenylation complex subunit PAN3 OS=Homo sapiens OX=9606 GN=PAN3 PE=1 SV=3" "0.000" "False" "7.126" "2" "2" "3" "2" "887" "95.6" "8.57" "8.91" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf18101" "255967" "ENSG00000152520" "PAN3" "A0N0X1; A1A4Y8; A1A4Y9; B1ALF1; B7Z3W7; hsa:255967; Q0D2P2; Q58A45; Q5HYG6; Q5T515; Q5T516; Q5TBA0; Q76E13; Q8NBA6" "Deadenylation of mRNA" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7663902288491648991" "False" "High" "IsMasterProtein" "Q96BD5" "PHD finger protein 21A OS=Homo sapiens OX=9606 GN=PHF21A PE=1 SV=1" "0.000" "False" "7.125" "3" "3" "3" "3" "680" "74.8" "9.45" "8.86" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628" "51317" "ENSG00000135365" "PHF21A" "D3DQP5; hsa:51317; Q6AWA2; Q96BD5; Q9C0G7; Q9H8V9; Q9HAK6; Q9NZE9" "HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS" "11p11.2 copy number variation syndrome" "4" "0" "1.038" "1.030" "1.049" "0.875" "0.839" "0.865" "0.916" "0.999" "1.089" "126.9" "131.7" "130.6" "133.1" "111.0" "106.5" "109.7" "116.2" "126.8" "138.1" "" "" "" "" "" "" "" "" "" "" "101.9" "95.0" "103.8" "89.2" "76.8" "79.9" "76.8" "84.9" "126.8" "112.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611870974223822516" "False" "High" "IsMasterProtein" "Q8NHP8" "Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2" "0.000" "False" "7.118" "4" "2" "2" "2" "589" "65.4" "6.80" "6.72" "2" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf04916" "196463" "ENSG00000151176" "PLBD2" "F5H5E2; hsa:196463; Q8NHP8" "" "" "0" "0" "0.988" "1.004" "0.960" "0.925" "1.043" "0.951" "0.873" "0.936" "0.954" "203.8" "201.3" "204.6" "195.7" "188.5" "212.5" "193.9" "178.0" "190.9" "194.3" "" "" "" "" "" "" "" "" "" "" "163.7" "145.3" "162.5" "131.1" "130.4" "159.4" "135.7" "130.0" "190.9" "158.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7892185460647837485" "False" "High" "IsMasterProtein" "Q53RE8" "Ankyrin repeat domain-containing protein 39 OS=Homo sapiens OX=9606 GN=ANKRD39 PE=1 SV=1" "0.000" "False" "7.110" "11" "2" "2" "2" "183" "19.6" "6.89" "7.74" "2" "" "" "" "Pf12796" "51239" "ENSG00000213337" "ANKRD39" "hsa:51239; Q53RE8; Q59FU2; Q8N5X5; Q9P0S5" "" "2q11.2 copy number variation syndrome" "1" "0" "0.934" "1.143" "1.296" "1.112" "1.281" "1.166" "1.067" "1.092" "1.357" "53.7" "50.2" "61.4" "69.6" "59.8" "68.8" "62.6" "57.3" "58.7" "72.9" "" "" "" "" "" "" "" "" "" "" "43.1" "36.2" "48.8" "46.6" "41.3" "51.6" "43.9" "41.9" "58.7" "59.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7658381107240133843" "False" "High" "IsMasterProtein" "Q5VT06" "Centrosome-associated protein 350 OS=Homo sapiens OX=9606 GN=CEP350 PE=1 SV=1" "0.000" "False" "7.098" "1" "2" "2" "2" "3117" "350.7" "6.33" "5.40" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14309" "9857" "ENSG00000135837" "CEP350" "hsa:9857; O75068; Q5VT06; Q8TDK3; Q8WY20" "" "3q29 copy number variation syndrome" "1" "0" "1.163" "1.129" "1.263" "1.207" "0.970" "1.322" "1.179" "1.187" "1.088" "63.8" "74.1" "72.0" "80.6" "77.0" "61.9" "84.3" "75.2" "75.7" "69.4" "" "" "" "" "" "" "" "" "" "" "51.2" "53.5" "57.2" "54.0" "53.2" "46.4" "59.0" "54.9" "75.7" "56.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527678404860705700" "False" "High" "IsMasterProtein" "Q96K21" "Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3" "0.000" "False" "7.081" "7" "3" "5" "3" "471" "51.5" "5.73" "8.74" "3" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf01363" "84936" "ENSG00000166140" "ZFYVE19" "B3KVB2; C9JNF4; H3BUF9; hsa:84936; Q86WC2; Q8WU96; Q96K21" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3671044703828266171" "False" "High" "IsMasterProtein" "Q9C086" "INO80 complex subunit B OS=Homo sapiens OX=9606 GN=INO80B PE=1 SV=2" "0.000" "False" "7.080" "4" "1" "1" "1" "356" "38.6" "9.61" "5.02" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf04438, Pf04795" "83444" "ENSG00000115274" "INO80B" "hsa:83444; Q9C086" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "1.004" "1.045" "1.149" "1.058" "1.004" "1.166" "1.107" "0.997" "1.162" "117.1" "117.5" "122.4" "134.5" "123.9" "117.6" "136.5" "129.6" "116.8" "136.1" "" "" "" "" "" "" "" "" "" "" "94.0" "84.8" "97.2" "90.1" "85.7" "88.2" "95.6" "94.7" "116.8" "110.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240995388596956577" "False" "High" "IsMasterProtein" "Q08379" "Golgin subfamily A member 2 OS=Homo sapiens OX=9606 GN=GOLGA2 PE=1 SV=3" "0.000" "False" "7.078" "2" "2" "2" "2" "1002" "113.0" "5.02" "4.27" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf15070, Pf19046" "2801" "ENSG00000167110" "GOLGA2" "A0A0C4DGS5; hsa:2801; Q08379; Q6GRM9; Q9BRB0; Q9NYF9" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Golgi Cisternae Pericentriolar Stack Reorganization" "" "4" "0" "0.497" "0.738" "0.622" "0.941" "0.737" "0.873" "1.064" "1.139" "0.882" "19.7" "9.8" "14.6" "12.3" "18.6" "14.5" "17.2" "21.0" "22.5" "17.4" "" "" "" "" "" "" "" "" "" "" "15.8" "7.1" "11.6" "8.2" "12.8" "10.9" "12.1" "15.3" "22.5" "14.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4548517045609742799" "False" "High" "IsMasterProtein" "Q9NVR5" "Protein kintoun OS=Homo sapiens OX=9606 GN=DNAAF2 PE=1 SV=2" "0.000" "False" "7.073" "2" "2" "2" "2" "837" "91.1" "5.20" "6.10" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "" "Pf08190, Pf18201" "55172" "ENSG00000165506" "DNAAF2" "B9WS54; C0JAP7; hsa:55172; Q86TR1; Q86TY8; Q969Z5; Q9NVR5" "" "Ciliopathies" "1" "0" "0.962" "1.190" "1.040" "0.873" "1.183" "1.025" "0.777" "1.040" "1.112" "43.0" "41.3" "51.2" "44.7" "37.5" "50.9" "44.1" "33.4" "44.7" "47.8" "" "" "" "" "" "" "" "" "" "" "34.5" "29.8" "40.7" "30.0" "26.0" "38.2" "30.9" "24.4" "44.7" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8582316469479536789" "False" "High" "IsMasterProtein" "Q92567" "Protein FAM168A OS=Homo sapiens OX=9606 GN=FAM168A PE=1 SV=2" "0.000" "False" "7.067" "7" "2" "2" "2" "244" "26.2" "8.98" "8.22" "2" "other biological processes" "" "" "Pf14944" "23201" "ENSG00000054965" "FAM168A" "A2ICY2; A2ID81; hsa:23201; Q86UG2; Q92567" "" "" "0" "0" "1.060" "1.064" "0.859" "0.953" "1.035" "0.837" "0.997" "1.023" "0.947" "384.7" "407.8" "409.3" "330.5" "366.5" "398.2" "322.0" "383.6" "393.4" "364.4" "" "" "" "" "" "" "" "" "" "" "309.0" "294.2" "325.1" "221.4" "253.5" "298.8" "225.5" "280.1" "393.4" "296.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1243258225011339674" "False" "High" "IsMasterProtein" "Q9NP87" "DNA-directed DNA/RNA polymerase mu OS=Homo sapiens OX=9606 GN=POLM PE=1 SV=1" "0.000" "False" "7.063" "3" "1" "1" "1" "494" "54.8" "8.41" "3.72" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf10391, Pf14716, Pf14791, Pf14792" "27434" "ENSG00000122678" "POLM" "D3DVK4; hsa:27434; Q6P5X8; Q86WQ9; Q9NP87" "Nonhomologous End-Joining (NHEJ)" "Non-homologous end joining; DNA repair pathways, full network" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739657141075103728" "False" "High" "IsMasterProtein" "Q9NRN9" "rRNA N6-adenosine-methyltransferase METTL5 OS=Homo sapiens OX=9606 GN=METTL5 PE=1 SV=1" "0.000" "False" "7.061" "8" "2" "2" "2" "209" "23.7" "6.68" "6.01" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29081" "ENSG00000138382" "METTL5" "D3DPC9; hsa:29081; Q9NRN9; Q9NVX1" "" "" "0" "0" "0.949" "1.029" "0.873" "1.004" "1.029" "0.846" "0.928" "0.955" "0.971" "304.1" "288.5" "313.0" "265.6" "305.3" "313.0" "257.2" "282.3" "290.2" "295.1" "" "" "" "" "" "" "" "" "" "" "244.2" "208.2" "248.6" "177.9" "211.2" "234.8" "180.1" "206.1" "290.2" "240.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5516289566189376071" "False" "High" "IsMasterProtein" "Q13084" "Large ribosomal subunit protein bL28m OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4" "0.000" "False" "7.058" "7" "2" "2" "2" "256" "30.1" "8.29" "6.51" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00830" "10573" "ENSG00000086504" "MRPL28" "B2RCM4; D3DU46; hsa:10573; Q13084; Q4TT39; Q96S26; Q9BQD8; Q9BR04" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.980" "1.106" "1.088" "1.027" "1.116" "1.206" "1.141" "1.099" "1.110" "120.7" "118.3" "133.5" "131.3" "123.9" "134.6" "145.5" "137.7" "132.6" "133.9" "" "" "" "" "" "" "" "" "" "" "96.9" "85.3" "106.0" "88.0" "85.7" "101.0" "101.9" "100.6" "132.6" "108.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541658205894384730" "False" "High" "IsMasterProtein" "Q8N8R7" "ARL14 effector protein OS=Homo sapiens OX=9606 GN=ARL14EP PE=1 SV=1" "0.000" "False" "7.038" "10" "2" "2" "2" "260" "29.3" "8.07" "6.61" "2" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf14949" "120534" "ENSG00000152219" "ARL14EP" "hsa:120534; Q5HYH9; Q8N8R7" "" "" "0" "0" "1.058" "0.924" "0.981" "1.077" "1.053" "0.902" "0.949" "1.037" "0.999" "103.3" "109.3" "95.4" "101.3" "111.3" "108.8" "93.2" "98.1" "107.1" "103.2" "" "" "" "" "" "" "" "" "" "" "83.0" "78.9" "75.8" "67.9" "77.0" "81.6" "65.3" "71.6" "107.1" "83.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7474037307863270970" "False" "High" "IsMasterProtein" "Q96TC7" "Regulator of microtubule dynamics protein 3 OS=Homo sapiens OX=9606 GN=RMDN3 PE=1 SV=2" "0.000" "False" "7.029" "4" "2" "2" "2" "470" "52.1" "5.10" "5.76" "2" "other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity" "Pf21033" "55177" "ENSG00000137824" "RMDN3" "A9UMZ9; B3KRR3; hsa:55177; Q6ZWE9; Q96H23; Q96SD6; Q96TC7; Q9H6G1; Q9NVQ6" "" "" "0" "0" "1.039" "0.858" "0.945" "0.940" "0.999" "0.816" "0.886" "0.993" "0.853" "156.1" "162.2" "134.0" "147.6" "146.8" "156.0" "127.4" "138.3" "155.0" "133.2" "" "" "" "" "" "" "" "" "" "" "125.4" "117.0" "106.5" "98.9" "101.5" "117.0" "89.2" "101.0" "155.0" "108.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289825156273590713" "False" "High" "IsMasterProtein" "Q5JTV8" "Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1 PE=1 SV=2" "0.000" "False" "7.025" "2" "1" "2" "1" "583" "66.2" "8.18" "4.58" "1" "cell organization and biogenesis;other biological processes" "other membranes;nucleus" "cytoskeletal activity;other molecular function" "Pf05609, Pf20443" "26092" "ENSG00000143337" "TOR1AIP1" "A0A0A0MSK5; A8K630; B0QZ57; hsa:26092; Q5JTV6; Q5JTV8; Q8IZ65; Q9H8Y6; Q9HAJ1; Q9NV52; Q9Y3X5" "RHOD GTPase cycle; RHOF GTPase cycle" "Influence of laminopathies on Wnt signaling" "3" "0" "1.261" "1.306" "1.189" "1.096" "1.098" "1.292" "1.034" "0.964" "1.153" "88.5" "111.6" "115.6" "105.3" "97.0" "97.2" "114.3" "91.5" "85.3" "102.1" "" "" "" "" "" "" "" "" "" "" "71.1" "80.5" "91.8" "70.5" "67.1" "72.9" "80.0" "66.8" "85.3" "83.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8924414405991965446" "False" "High" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "0.000" "False" "7.024" "14" "2" "3" "2" "157" "17.2" "8.91" "9.38" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "1.047" "0.902" "0.910" "1.114" "1.167" "0.824" "1.112" "1.081" "1.005" "88.5" "92.7" "79.8" "80.5" "98.6" "103.3" "72.9" "98.4" "95.7" "88.9" "" "" "" "" "" "" "" "" "" "" "71.1" "66.9" "63.4" "54.0" "68.2" "77.5" "51.1" "71.9" "95.7" "72.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697887679993430442" "False" "High" "IsMasterProtein" "Q8IYH5" "ZZ-type zinc finger-containing protein 3 OS=Homo sapiens OX=9606 GN=ZZZ3 PE=1 SV=1" "0.000" "False" "7.017" "2" "2" "2" "2" "903" "102.0" "5.69" "7.09" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00569" "26009" "ENSG00000036549" "ZZZ3" "B7WPC6; hsa:26009; Q6N004; Q6N070; Q8IYH5; Q8IYP0; Q8IYR1; Q8TEK4; Q9Y4U0" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "0.920" "0.982" "1.026" "1.056" "0.910" "1.163" "0.984" "1.116" "0.998" "101.3" "93.2" "99.5" "104.0" "107.1" "92.2" "117.9" "99.7" "113.1" "101.1" "" "" "" "" "" "" "" "" "" "" "81.4" "67.3" "79.0" "69.7" "74.0" "69.2" "82.5" "72.8" "113.1" "82.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7530688595643988973" "False" "High" "IsMasterProtein" "Q13510" "Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5" "0.000" "False" "7.016" "3" "1" "1" "1" "395" "44.6" "7.62" "4.73" "1" "other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "427" "ENSG00000104763" "ASAH1" "E9PDS0; hsa:427; Q13510; Q6W898; Q96AS2" "Neutrophil degranulation; Glycosphingolipid catabolism" "Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Synthesis of ceramides and 1-deoxyceramides" "8" "0" "1.049" "1.106" "1.026" "0.976" "1.121" "1.063" "1.051" "1.141" "1.078" "195.8" "205.4" "216.6" "200.9" "191.2" "219.4" "208.2" "205.8" "223.4" "211.0" "" "" "" "" "" "" "" "" "" "" "157.3" "148.2" "172.0" "134.6" "132.2" "164.6" "145.8" "150.3" "223.4" "171.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7784023466259841542" "False" "High" "IsMasterProtein" "B0I1T2" "Unconventional myosin-Ig OS=Homo sapiens OX=9606 GN=MYO1G PE=1 SV=2" "0.000" "False" "7.009" "2" "1" "1" "1" "1018" "116.4" "8.73" "4.24" "1" "cell adhesion;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf06017" "64005" "ENSG00000136286" "MYO1G" "B0I1T2; hsa:64005; Q8TEI9; Q8TES2; Q96BE2; Q96RI5; Q96RI6" "" "" "0" "0" "1.275" "0.854" "1.148" "1.121" "1.064" "1.183" "0.754" "1.075" "0.800" "31.7" "40.5" "27.1" "36.4" "35.6" "33.8" "37.6" "23.9" "34.1" "25.4" "" "" "" "" "" "" "" "" "" "" "25.5" "29.2" "21.5" "24.4" "24.6" "25.3" "26.3" "17.5" "34.1" "20.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1198198230857353565" "False" "High" "IsMasterProtein" "O43169" "Cytochrome b5 type B OS=Homo sapiens OX=9606 GN=CYB5B PE=1 SV=3" "0.000" "False" "7.001" "8" "1" "1" "1" "150" "16.7" "4.97" "4.32" "1" "other metabolic processes;stress response" "other membranes;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00173" "80777" "ENSG00000103018" "CYB5B" "A8K6B1; hsa:80777; J3KNF8; O43169; Q96CC3; Q9BT35" "Sphingolipid de novo biosynthesis; Phase I - Functionalization of compounds" "Oxidation by cytochrome P450" "3" "0" "0.987" "1.230" "1.073" "0.865" "1.271" "1.065" "1.011" "1.305" "1.145" "38.2" "37.7" "47.0" "41.0" "33.1" "48.6" "40.7" "38.7" "49.9" "43.8" "" "" "" "" "" "" "" "" "" "" "30.7" "27.2" "37.4" "27.5" "22.9" "36.5" "28.5" "28.2" "49.9" "35.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1220835464658620030" "False" "High" "IsMasterProtein" "Q7L2E3" "ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1" "0.000" "False" "6.993" "2" "2" "2" "2" "1194" "133.9" "8.78" "6.00" "2" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf07717, Pf21010" "22907" "ENSG00000132153" "DHX30" "A8K5F1; hsa:22907; O94965; Q7L2E3; Q7Z753; Q96CH4; Q9NUQ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3522483334195236405" "False" "High" "IsMasterProtein" "Q13542" "Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1" "0.000" "False" "6.962" "23" "2" "3" "2" "120" "12.9" "6.67" "7.26" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05456" "1979" "ENSG00000148730" "EIF4EBP2" "hsa:1979; Q13542" "" "Translation factors; Fragile X syndrome" "2" "0" "1.312" "1.110" "1.174" "1.121" "1.293" "1.250" "0.975" "1.228" "1.342" "59.3" "77.9" "65.9" "69.7" "66.5" "76.7" "74.2" "57.8" "72.9" "79.6" "" "" "" "" "" "" "" "" "" "" "47.7" "56.2" "52.3" "46.7" "46.0" "57.6" "51.9" "42.2" "72.9" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2318951358478494228" "False" "High" "IsMasterProtein" "Q8WW01" "tRNA-splicing endonuclease subunit Sen15 OS=Homo sapiens OX=9606 GN=TSEN15 PE=1 SV=1" "0.000" "False" "6.958" "9" "1" "2" "1" "171" "18.6" "4.58" "3.26" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf09631" "116461" "ENSG00000198860" "TSEN15" "B4DKP0; hsa:116461; Q8WW01; Q9BZQ5" "tRNA processing in the nucleus" "" "1" "0" "1.155" "0.954" "1.302" "1.092" "1.036" "1.008" "0.907" "0.982" "1.114" "54.3" "62.7" "51.8" "70.7" "59.3" "56.3" "54.7" "49.3" "53.3" "60.5" "" "" "" "" "" "" "" "" "" "" "43.6" "45.2" "41.2" "47.4" "41.0" "42.2" "38.3" "36.0" "53.3" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4278249940828633973" "False" "High" "IsMasterProtein" "P32321" "Deoxycytidylate deaminase OS=Homo sapiens OX=9606 GN=DCTD PE=1 SV=2" "0.000" "False" "6.956" "12" "2" "3" "2" "178" "20.0" "7.56" "5.15" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00383" "1635" "ENSG00000129187" "DCTD" "B2R836; D3DP49; D3DP50; hsa:1635; P32321; Q5M7Z8; Q9BVD8" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3849274809303235677" "False" "High" "IsMasterProtein" "Q6PHR2" "Serine/threonine-protein kinase ULK3 OS=Homo sapiens OX=9606 GN=ULK3 PE=1 SV=2" "0.000" "False" "6.944" "6" "2" "2" "2" "472" "53.4" "7.36" "3.13" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf04212" "25989" "ENSG00000140474" "ULK3" "B2RXK3; B4DFT0; B4DRQ7; D3DW68; hsa:25989; Q6PHR2; Q9NPN5; Q9UFS4" "Hedgehog 'on' state" "Target of rapamycin signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562001215224967399" "False" "High" "IsMasterProtein" "Q9H254" "Spectrin beta chain, non-erythrocytic 4 OS=Homo sapiens OX=9606 GN=SPTBN4 PE=1 SV=2" "0.000" "False" "6.943" "1" "2" "2" "1" "2564" "288.8" "6.01" "6.79" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf15410" "57731" "ENSG00000160460" "SPTBN4" "E9PGQ5; hsa:57731; Q9H1K7; Q9H1K8; Q9H1K9; Q9H253; Q9H254; Q9H3G8; Q9HCD0" "COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins" "" "4" "0" "1.042" "0.964" "1.192" "1.050" "1.054" "1.114" "0.917" "1.024" "0.921" "82.2" "85.6" "79.2" "98.0" "86.3" "86.6" "91.6" "75.3" "84.1" "75.7" "" "" "" "" "" "" "" "" "" "" "66.0" "61.8" "62.9" "65.6" "59.7" "65.0" "64.1" "55.0" "84.1" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9173522146093415156" "False" "High" "IsMasterProtein" "Q9P0J7" "E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2" "0.000" "False" "6.916" "4" "2" "2" "2" "381" "41.9" "5.66" "6.78" "2" "cell-cell signaling" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00569, Pf05605" "56888" "ENSG00000176407" "KCMF1" "Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9P0J7; Q9UFE8" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "255349237203839233" "False" "High" "IsMasterProtein" "Q9Y2Y1" "DNA-directed RNA polymerase III subunit RPC10 OS=Homo sapiens OX=9606 GN=POLR3K PE=1 SV=3" "0.000" "False" "6.911" "21" "2" "2" "2" "108" "12.3" "7.83" "7.29" "2" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf02150" "51728" "ENSG00000161980" "POLR3K" "hsa:51728; Q1W6H4; Q96S35; Q9Y2Y1" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "0.934" "0.962" "1.038" "1.021" "1.029" "1.187" "1.053" "1.122" "1.130" "125.1" "116.9" "120.4" "129.9" "127.8" "128.8" "148.6" "131.8" "140.4" "141.4" "" "" "" "" "" "" "" "" "" "" "100.5" "84.4" "95.6" "87.0" "88.4" "96.6" "104.0" "96.3" "140.4" "115.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6795582567929622559" "False" "High" "IsMasterProtein" "P61916" "NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1" "0.000" "False" "6.910" "11" "2" "2" "2" "151" "16.6" "7.65" "7.73" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf02221" "10577" "ENSG00000119655" "NPC2" "B4DQV7; P61916; Q15668; Q29413" "Neutrophil degranulation; LDL clearance" "TYROBP causal network in microglia; Degradation pathway of sphingolipids, including diseases; Ebola virus infection in host; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "7" "0" "1.139" "1.039" "1.011" "1.086" "1.065" "1.051" "1.198" "1.090" "1.081" "343.1" "390.7" "356.6" "346.8" "372.8" "365.2" "360.7" "411.1" "374.1" "370.8" "" "" "" "" "" "" "" "" "" "" "275.6" "281.9" "283.3" "232.3" "257.8" "274.0" "252.5" "300.2" "374.1" "301.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8771198256922364078" "False" "High" "IsMasterProtein" "P10244" "Myb-related protein B OS=Homo sapiens OX=9606 GN=MYBL2 PE=1 SV=1" "0.000" "False" "6.885" "6" "3" "3" "3" "700" "78.7" "6.87" "7.95" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf09316, Pf13921" "4605" "ENSG00000101057" "MYBL2" "B2RBS5; B7Z8D9; F8W6N6; hsa:4605; P10244; Q53F07" "Polo-like kinase mediated events; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Gastric cancer network 1; EGF/EGFR signaling pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8564322409184755345" "False" "High" "IsMasterProtein" "Q9Y4K3" "TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1" "0.000" "False" "6.883" "4" "3" "3" "3" "522" "59.5" "6.44" "6.23" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf13923, Pf18048, Pf21355" "7189" "ENSG00000175104" "TRAF6" "A6NKI7; A8KAB3; D3DR16; hsa:7189; Q8NEH5; Q9Y4K3" "FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PIP3 activates AKT signaling; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Clock-controlled autophagy in bone metabolism; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "78" "0" "1.083" "0.936" "1.131" "0.963" "1.085" "1.049" "0.984" "1.126" "1.131" "56.9" "61.7" "53.3" "64.4" "54.9" "61.8" "59.7" "56.0" "64.1" "64.4" "" "" "" "" "" "" "" "" "" "" "45.7" "44.5" "42.3" "43.1" "37.9" "46.4" "41.8" "40.9" "64.1" "52.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3666835465541347575" "False" "High" "IsMasterProtein" "Q14684" "Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3" "0.000" "False" "6.882" "3" "3" "3" "3" "758" "84.4" "9.76" "8.11" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05997" "23076" "ENSG00000160208" "RRP1B" "hsa:23076; Q14684; Q8TBZ4" "" "" "0" "0" "1.139" "1.117" "1.148" "1.298" "1.101" "1.148" "1.128" "1.094" "1.202" "144.9" "165.1" "161.9" "166.3" "188.1" "159.6" "166.3" "163.5" "158.4" "174.1" "" "" "" "" "" "" "" "" "" "" "116.4" "119.1" "128.6" "111.4" "130.1" "119.7" "116.4" "119.4" "158.4" "141.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1703927075416448593" "False" "High" "IsMasterProtein" "P07477" "Serine protease 1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1" "0.000" "False" "6.878" "11" "2" "7" "1" "247" "26.5" "6.51" "11.51" "2" "cell organization and biogenesis;protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "5644" "ENSG00000204983; ENSG00000274247" "PRSS1" "A1A509; A6NJ71; B2R5I5; hsa:5644; P07477; Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7" "Uptake of dietary cobalamins into enterocytes; Activation of Matrix Metalloproteinases" "" "2" "0" "0.984" "1.100" "1.196" "1.212" "1.158" "1.134" "1.315" "1.146" "1.168" "325.6" "320.2" "358.1" "389.3" "394.7" "377.2" "369.3" "428.0" "373.1" "380.3" "" "" "" "" "" "" "" "" "" "" "261.5" "231.1" "284.4" "260.8" "273.0" "283.0" "258.6" "312.6" "373.1" "309.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1059479588145878026" "False" "High" "IsMasterProtein" "O75145" "Liprin-alpha-3 OS=Homo sapiens OX=9606 GN=PPFIA3 PE=1 SV=3" "0.000" "False" "6.877" "3" "3" "3" "2" "1194" "133.4" "5.68" "8.42" "3" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "" "Pf00536, Pf07647" "8541" "ENSG00000177380" "PPFIA3" "A8K142; hsa:8541; O75145; Q3MJA0; Q9H8B5; Q9UEW4" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases" "" "6" "0" "0.847" "1.029" "1.152" "1.048" "0.904" "0.933" "1.060" "1.153" "1.046" "191.1" "161.9" "196.6" "220.1" "200.3" "172.8" "178.2" "202.5" "220.3" "199.9" "" "" "" "" "" "" "" "" "" "" "153.5" "116.8" "156.2" "147.5" "138.6" "129.6" "124.8" "147.9" "220.3" "162.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3235762539968315400" "False" "High" "IsMasterProtein" "Q8WTV0" "Scavenger receptor class B member 1 OS=Homo sapiens OX=9606 GN=SCARB1 PE=1 SV=1" "0.000" "False" "6.870" "3" "2" "2" "2" "552" "60.8" "8.24" "6.22" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01130" "949" "ENSG00000073060" "SCARB1" "F8W8N0; hsa:949; Q14016; Q52LZ5; Q6KFX4; Q8WTV0" "" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; SARS-CoV-2 and COVID-19 pathway; Familial hyperlipidemia type 3; Cholesterol metabolism; Vitamin A and carotenoid metabolism" "9" "0" "0.795" "0.870" "1.034" "1.094" "0.972" "1.120" "1.011" "0.971" "0.920" "145.6" "115.8" "126.7" "150.6" "159.2" "141.5" "163.1" "147.2" "141.4" "133.9" "" "" "" "" "" "" "" "" "" "" "116.9" "83.5" "100.6" "100.9" "110.1" "106.2" "114.2" "107.5" "141.4" "108.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3903200629464870595" "False" "High" "IsMasterProtein" "Q6P6B7" "Ankyrin repeat domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ANKRD16 PE=1 SV=1" "0.000" "False" "6.866" "4" "1" "1" "1" "361" "39.3" "7.25" "4.64" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf12796" "54522" "ENSG00000134461" "ANKRD16" "A6NEF0; F8WEI4; hsa:54522; Q6P6B7; Q9NT01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1865855424515257827" "False" "High" "IsMasterProtein" "Q9H0F6" "Sharpin OS=Homo sapiens OX=9606 GN=SHARPIN PE=1 SV=1" "0.000" "False" "6.861" "3" "1" "1" "1" "387" "39.9" "5.80" "4.92" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16764" "81858" "ENSG00000179526" "SHARPIN" "A6NEG3; C0L3L2; D3DWL3; hsa:81858; Q8IXF5; Q8IXF6; Q8N2E7; Q8TB25; Q9BUE4; Q9H0F6" "Neurexins and neuroligins; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7542471958177645128" "False" "High" "IsMasterProtein" "Q8TBC3" "SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2" "0.000" "False" "6.853" "3" "2" "2" "2" "707" "76.3" "8.28" "6.39" "2" "cell organization and biogenesis;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf02214" "92799" "ENSG00000160410" "SHKBP1" "Q8N2I6; Q8TBC3; Q8WY93; Q96IB8" "CDC42 GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436639350970849740" "False" "High" "IsMasterProtein" "Q9UHB4" "NADPH-dependent diflavin oxidoreductase 1 OS=Homo sapiens OX=9606 GN=NDOR1 PE=1 SV=1" "0.000" "False" "6.848" "6" "3" "3" "3" "597" "66.7" "6.35" "7.01" "3" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "27158" "ENSG00000188566" "NDOR1" "D3YTG6; D3YTH9; hsa:27158; Q5VSG4; Q86US9; Q96BC6; Q9UHB4" "Cytosolic iron-sulfur cluster assembly" "" "1" "0" "1.200" "1.319" "1.535" "1.418" "1.512" "1.400" "1.227" "1.415" "1.336" "40.4" "48.4" "53.2" "62.0" "57.2" "61.0" "56.5" "49.5" "57.1" "53.9" "" "" "" "" "" "" "" "" "" "" "32.4" "35.0" "42.3" "41.5" "39.6" "45.8" "39.6" "36.1" "57.1" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7824146084782437899" "False" "High" "IsMasterProtein" "P41162" "ETS translocation variant 3 OS=Homo sapiens OX=9606 GN=ETV3 PE=1 SV=2" "0.000" "False" "6.832" "4" "2" "2" "1" "512" "57.0" "8.57" "5.59" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "2117" "ENSG00000117036" "ETV3" "B4E3M7; hsa:2117; P41162; Q8TAC8; Q9BX30" "" "" "0" "0" "1.331" "1.350" "1.108" "1.667" "1.247" "1.387" "1.293" "1.337" "1.154" "21.0" "28.0" "28.4" "23.3" "35.1" "26.2" "29.2" "27.2" "28.1" "24.3" "" "" "" "" "" "" "" "" "" "" "16.9" "20.2" "22.6" "15.6" "24.3" "19.7" "20.4" "19.9" "28.1" "19.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1958411892958280270" "False" "High" "IsMasterProtein" "A0AVK6" "Transcription factor E2F8 OS=Homo sapiens OX=9606 GN=E2F8 PE=1 SV=1" "0.000" "False" "6.818" "2" "2" "2" "2" "867" "94.1" "8.98" "5.73" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319" "79733" "ENSG00000129173" "E2F8" "A0AVK6; A8K9H3; hsa:79733; Q2VPJ3; Q3C1U6; Q5BKY4; Q8N340; Q9H5M0" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490107994498796069" "False" "High" "IsMasterProtein" "Q8WVC0" "RNA polymerase-associated protein LEO1 OS=Homo sapiens OX=9606 GN=LEO1 PE=1 SV=1" "0.000" "False" "6.818" "9" "3" "3" "3" "666" "75.4" "4.51" "0.00" "3" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf04004" "123169" "ENSG00000166477" "LEO1" "hsa:123169; Q8WVC0; Q96N99" "RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex" "Endoderm differentiation" "6" "0" "0.875" "1.487" "1.184" "0.910" "0.860" "0.851" "0.842" "1.334" "1.524" "12.0" "10.5" "17.9" "14.3" "11.0" "10.4" "10.2" "10.1" "16.1" "18.3" "" "" "" "" "" "" "" "" "" "" "9.7" "7.6" "14.2" "9.6" "7.6" "7.8" "7.2" "7.4" "16.1" "14.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1889758281858521724" "False" "High" "IsMasterProtein" "Q53HC5" "Kelch-like protein 26 OS=Homo sapiens OX=9606 GN=KLHL26 PE=1 SV=2" "0.000" "False" "6.812" "2" "1" "1" "1" "615" "68.1" "6.48" "3.90" "1" "" "" "" "Pf00651, Pf01344, Pf07707, Pf13964" "55295" "ENSG00000167487" "KLHL26" "hsa:55295; Q53HC5; Q8TAP0; Q9NUX3" "" "" "0" "0" "1.176" "1.124" "1.215" "1.302" "1.273" "1.188" "1.233" "1.373" "1.327" "112.6" "132.4" "126.6" "136.8" "146.6" "143.3" "133.8" "138.9" "154.6" "149.4" "" "" "" "" "" "" "" "" "" "" "90.4" "95.5" "100.5" "91.7" "101.4" "107.5" "93.7" "101.4" "154.6" "121.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8681135963765944837" "False" "High" "IsMasterProtein" "Q01892" "Transcription factor Spi-B OS=Homo sapiens OX=9606 GN=SPIB PE=1 SV=1" "0.000" "False" "6.793" "5" "1" "1" "1" "262" "28.8" "5.52" "4.28" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "6689" "ENSG00000269404" "SPIB" "A8K9C9; B4DUG6; hsa:6689; Q01892; Q15359" "" "" "0" "0" "0.824" "0.942" "0.999" "0.965" "1.052" "0.833" "0.908" "0.779" "0.900" "87.7" "72.3" "82.6" "87.6" "84.6" "92.3" "73.1" "79.7" "68.3" "78.9" "" "" "" "" "" "" "" "" "" "" "70.5" "52.2" "65.6" "58.7" "58.5" "69.3" "51.2" "58.2" "68.3" "64.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2226975815601185074" "False" "High" "IsMasterProtein" "Q15742" "NGFI-A-binding protein 2 OS=Homo sapiens OX=9606 GN=NAB2 PE=1 SV=1" "0.000" "False" "6.778" "5" "3" "3" "3" "525" "56.6" "6.96" "5.97" "3" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf04904, Pf04905" "4665" "ENSG00000166886" "NAB2" "B2RAK3; hsa:4665; O76006; Q14797; Q15742" "NGF-stimulated transcription; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "" "2" "0" "1.060" "1.011" "0.994" "1.068" "0.900" "1.109" "1.289" "1.254" "1.115" "198.7" "210.7" "200.9" "197.5" "212.3" "178.8" "220.4" "256.2" "249.2" "221.6" "" "" "" "" "" "" "" "" "" "" "159.6" "152.0" "159.6" "132.4" "146.8" "134.1" "154.3" "187.1" "249.2" "180.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1373534053104032037" "False" "High" "IsMasterProtein" "O14653" "Golgi SNAP receptor complex member 2 OS=Homo sapiens OX=9606 GN=GOSR2 PE=1 SV=2" "0.000" "False" "6.775" "10" "2" "2" "2" "212" "24.8" "8.06" "6.11" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf12352" "9570" "ENSG00000108433" "GOSR2" "D3DXJ5; D3DXJ6; hsa:9570; O14653; Q8N4B8; Q96DA5; Q9BZZ4" "COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER" "" "5" "0" "1.222" "1.087" "1.218" "1.269" "1.166" "1.159" "0.964" "1.082" "1.345" "78.5" "95.9" "85.2" "95.6" "99.5" "91.5" "90.9" "75.6" "84.9" "105.5" "" "" "" "" "" "" "" "" "" "" "63.0" "69.2" "67.7" "64.0" "68.8" "68.6" "63.6" "55.2" "84.9" "85.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5145087697178070665" "False" "High" "IsMasterProtein" "Q9H4I2" "Zinc fingers and homeoboxes protein 3 OS=Homo sapiens OX=9606 GN=ZHX3 PE=1 SV=3" "0.000" "False" "6.754" "2" "1" "1" "1" "956" "104.6" "6.07" "4.03" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf11569, Pf18387" "23051" "ENSG00000174306" "ZHX3" "E1P5W5; F5H820; hsa:23051; O43145; Q6NUJ7; Q9H4I2" "" "" "0" "0" "1.040" "0.835" "0.942" "0.979" "0.932" "1.151" "0.887" "0.946" "0.910" "39.8" "41.4" "33.2" "37.5" "38.9" "37.1" "45.8" "35.3" "37.6" "36.2" "" "" "" "" "" "" "" "" "" "" "32.0" "29.9" "26.4" "25.1" "26.9" "27.8" "32.1" "25.8" "37.6" "29.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739885640391199971" "False" "High" "IsMasterProtein" "Q8IY57" "YY1-associated factor 2 OS=Homo sapiens OX=9606 GN=YAF2 PE=1 SV=3" "0.000" "False" "6.739" "18" "2" "3" "1" "180" "19.9" "9.72" "7.82" "2" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "10138" "ENSG00000015153" "YAF2" "A8K5P0; B4DFU3; G3V465; hsa:10138; Q8IY57; Q99710" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "High" "High" "Not Found" "High" "High" "Not Found" "Not Found" "1" "" "-813312959545056598" "False" "High" "IsMasterProtein" "Q96DT7" "Zinc finger and BTB domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZBTB10 PE=1 SV=2" "0.000" "False" "6.735" "3" "1" "1" "1" "871" "94.8" "5.16" "4.45" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651" "65986" "ENSG00000205189" "ZBTB10" "A4FVD0; hsa:65986; Q86W96; Q8IXI9; Q96DT7; Q96MH9" "" "" "0" "0" "0.896" "1.028" "1.091" "0.888" "0.821" "0.890" "0.827" "1.100" "1.220" "27.3" "24.4" "28.0" "29.8" "24.2" "22.4" "24.3" "22.6" "30.0" "33.3" "" "" "" "" "" "" "" "" "" "" "21.9" "17.6" "22.3" "19.9" "16.8" "16.8" "17.0" "16.5" "30.0" "27.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2136738707448998118" "False" "High" "IsMasterProtein" "Q8NI77" "Kinesin-like protein KIF18A OS=Homo sapiens OX=9606 GN=KIF18A PE=1 SV=2" "0.000" "False" "6.730" "2" "2" "2" "1" "898" "102.2" "8.91" "5.66" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "81930" "ENSG00000121621" "KIF18A" "hsa:81930; Q4VPE3; Q86VS5; Q8NI77; Q9H0F3" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "9" "0" "0.797" "0.917" "0.839" "0.830" "0.916" "1.176" "1.257" "1.068" "1.044" "101.2" "80.7" "92.8" "84.9" "84.0" "92.7" "119.0" "127.2" "108.1" "105.7" "" "" "" "" "" "" "" "" "" "" "81.3" "58.2" "73.7" "56.9" "58.1" "69.5" "83.3" "92.9" "108.1" "86.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4722809731006219467" "False" "High" "IsMasterProtein" "P48047" "ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1" "0.000" "False" "6.729" "10" "1" "1" "1" "213" "23.3" "9.96" "6.18" "1" "other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion" "transporter activity" "Pf00213" "539" "ENSG00000241837" "ATP5PO" "B2R4E2; hsa:539; P48047; Q5U042; Q6IBI2" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "6" "0" "1.127" "1.375" "1.335" "1.136" "1.133" "1.194" "1.412" "1.179" "1.262" "21.4" "24.1" "29.5" "28.6" "24.4" "24.3" "25.6" "30.3" "25.3" "27.0" "" "" "" "" "" "" "" "" "" "" "17.2" "17.4" "23.4" "19.2" "16.8" "18.2" "17.9" "22.1" "25.3" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2803114814399122734" "False" "High" "IsMasterProtein" "Q8NFI3" "Cytosolic endo-beta-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=ENGASE PE=1 SV=1" "0.000" "False" "6.728" "5" "4" "4" "4" "743" "83.9" "6.79" "4.81" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf03644" "64772" "ENSG00000167280" "ENGASE" "hsa:64772; Q659F0; Q8NFI3; Q8TB86; Q9H6U4" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2350157100316075220" "False" "High" "IsMasterProtein" "Q9UPG8" "Zinc finger protein PLAGL2 OS=Homo sapiens OX=9606 GN=PLAGL2 PE=1 SV=1" "0.000" "False" "6.726" "5" "2" "2" "2" "496" "54.5" "8.65" "4.73" "2" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "5326" "ENSG00000126003" "PLAGL2" "A8K8T5; E1P5M3; hsa:5326; Q92584; Q9UPG8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-892714621047387398" "False" "High" "IsMasterProtein" "O00167" "Eyes absent homolog 2 OS=Homo sapiens OX=9606 GN=EYA2 PE=1 SV=2" "0.000" "False" "6.722" "4" "2" "2" "2" "538" "59.2" "6.48" "5.22" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00702" "2139" "ENSG00000064655" "EYA2" "hsa:2139; O00167; Q5JSW8; Q86U84; Q96CV6; Q96H97; Q99503; Q99812; Q9BWF6; Q9H4S3; Q9H4S9; Q9NPZ4; Q9UIX7" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "" "1" "0" "1.021" "0.924" "1.149" "1.254" "0.799" "0.920" "0.848" "1.042" "0.756" "37.9" "38.7" "35.0" "43.6" "47.6" "30.3" "34.9" "32.2" "39.5" "28.7" "" "" "" "" "" "" "" "" "" "" "30.5" "27.9" "27.8" "29.2" "32.9" "22.8" "24.4" "23.5" "39.5" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8429437180713985689" "False" "High" "IsMasterProtein" "Q13761" "Runt-related transcription factor 3 OS=Homo sapiens OX=9606 GN=RUNX3 PE=1 SV=2" "0.000" "False" "6.717" "6" "2" "2" "2" "415" "44.3" "9.47" "8.37" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "864" "ENSG00000020633" "RUNX3" "B1AJV5; hsa:864; Q12969; Q13760; Q13761" "Regulation of RUNX3 expression and activity; RUNX3 regulates BCL2L11 (BIM) transcription; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; RUNX3 regulates CDKN1A transcription; RUNX3 Regulates Immune Response and Cell Migration; RUNX3 regulates YAP1-mediated transcription; RUNX3 regulates NOTCH signaling; RUNX3 regulates RUNX1-mediated transcription" "TYROBP causal network in microglia; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502285001895834817" "False" "High" "IsMasterProtein" "Q99638" "Cell cycle checkpoint control protein RAD9A OS=Homo sapiens OX=9606 GN=RAD9A PE=1 SV=1" "0.000" "False" "6.708" "3" "1" "2" "1" "391" "42.5" "5.66" "10.66" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04139" "5883" "ENSG00000172613" "RAD9A" "B2RCZ8; hsa:5883; Q6FI29; Q96C41; Q99638" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; NF1 copy number variation syndrome ; DNA damage response" "14" "0" "0.993" "0.954" "0.900" "1.023" "0.924" "0.966" "0.981" "1.015" "0.879" "259.3" "257.4" "247.2" "233.3" "265.2" "239.6" "250.4" "254.3" "263.1" "227.8" "" "" "" "" "" "" "" "" "" "" "208.2" "185.7" "196.4" "156.3" "183.4" "179.7" "175.3" "185.7" "263.1" "185.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7428659199023683835" "False" "High" "IsMasterProtein" "Q96QT6" "PHD finger protein 12 OS=Homo sapiens OX=9606 GN=PHF12 PE=1 SV=2" "0.000" "False" "6.702" "3" "2" "2" "2" "1004" "109.6" "7.74" "5.16" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf16737" "57649" "ENSG00000109118" "PHF12" "hsa:57649; Q0VAI5; Q2TAK2; Q6ZML2; Q96QT6; Q9BV34; Q9H7U9; Q9P205" "" "" "0" "0" "0.922" "0.891" "0.886" "0.947" "0.971" "0.893" "0.827" "0.920" "0.767" "70.1" "64.7" "62.5" "62.1" "66.4" "68.1" "62.6" "58.0" "64.5" "53.8" "" "" "" "" "" "" "" "" "" "" "56.3" "46.7" "49.6" "41.6" "45.9" "51.1" "43.9" "42.4" "64.5" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-710496043913301714" "False" "High" "IsMasterProtein" "Q15714" "TSC22 domain family protein 1 OS=Homo sapiens OX=9606 GN=TSC22D1 PE=1 SV=3" "0.000" "False" "6.700" "2" "3" "6" "1" "1073" "109.6" "5.64" "11.06" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01166" "8848" "ENSG00000102804" "TSC22D1" "A0A087X0H8; B3KRL7; B9EGI0; hsa:8848; O00666; Q15714; Q6AHX5; Q6IBU1; Q8NCN1; Q96JS5" "" "Ectoderm differentiation; Ectoderm differentiation" "2" "0" "1.001" "0.977" "1.025" "0.953" "0.972" "1.038" "0.880" "0.970" "0.902" "246.2" "246.5" "240.5" "252.3" "234.7" "239.3" "255.5" "216.6" "238.8" "222.1" "" "" "" "" "" "" "" "" "" "" "197.7" "177.9" "191.0" "169.0" "162.3" "179.5" "178.9" "158.2" "238.8" "180.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533172368579844457" "False" "High" "IsMasterProtein" "P55055" "Oxysterols receptor LXR-beta OS=Homo sapiens OX=9606 GN=NR1H2 PE=1 SV=2" "0.000" "False" "6.672" "2" "1" "1" "1" "460" "50.9" "7.74" "4.57" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7376" "ENSG00000131408" "NR1H2" "A8K490; B4DNM6; E7EWA6; hsa:7376; P55055; Q12970; Q5I0Y1" "PPARA activates gene expression; Nuclear Receptor transcription pathway; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; SUMOylation of intracellular receptors; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; VLDLR internalisation and degradation; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake" "Nuclear receptors; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways" "12" "0" "1.213" "1.149" "1.200" "1.092" "1.064" "1.101" "0.996" "1.031" "1.007" "74.9" "90.8" "86.1" "89.8" "81.8" "79.7" "82.4" "74.6" "77.2" "75.4" "" "" "" "" "" "" "" "" "" "" "60.1" "65.5" "68.4" "60.2" "56.6" "59.8" "57.7" "54.5" "77.2" "61.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1316883428224227619" "False" "High" "IsMasterProtein" "Q8WYQ5" "Microprocessor complex subunit DGCR8 OS=Homo sapiens OX=9606 GN=DGCR8 PE=1 SV=1" "0.000" "False" "6.666" "3" "3" "3" "3" "773" "86.0" "5.95" "8.44" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "54487" "ENSG00000128191" "DGCR8" "B2R8G1; hsa:54487; Q6DCB2; Q6MZE9; Q6Y2L0; Q8WYQ5; Q96G39; Q96GP8; Q9H6L8; Q9H6T7; Q9NRW2" "Transcriptional Regulation by MECP2; MicroRNA (miRNA) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; DDX1 as a regulatory component of the Drosha microprocessor; 22q11.2 copy number variation syndrome" "6" "0" "1.050" "1.069" "0.989" "1.170" "1.016" "1.060" "1.005" "1.137" "1.141" "132.0" "138.6" "141.2" "130.6" "154.5" "134.2" "139.9" "132.7" "150.1" "150.7" "" "" "" "" "" "" "" "" "" "" "106.0" "100.0" "112.2" "87.5" "106.9" "100.7" "98.0" "96.9" "150.1" "122.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691749111498675631" "False" "High" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "0.000" "False" "6.647" "3" "1" "4" "1" "572" "61.8" "7.09" "13.58" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "CRMPs in Sema3A signaling" "" "1" "0" "1.105" "1.061" "1.112" "1.037" "1.003" "0.985" "0.974" "1.126" "1.094" "250.3" "276.6" "265.6" "278.2" "259.6" "251.1" "246.4" "243.7" "281.7" "273.8" "" "" "" "" "" "" "" "" "" "" "201.0" "199.6" "211.0" "186.4" "179.6" "188.4" "172.5" "178.0" "281.7" "222.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1010351863231639578" "False" "High" "IsMasterProtein" "Q8IW41" "MAP kinase-activated protein kinase 5 OS=Homo sapiens OX=9606 GN=MAPKAPK5 PE=1 SV=2" "0.000" "False" "6.626" "4" "2" "3" "1" "473" "54.2" "7.78" "9.55" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8550" "ENSG00000089022" "MAPKAPK5" "B3KVA5; hsa:8550; O60491; Q86X46; Q8IW41; Q9BVX9; Q9UG86" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Regulation of TP53 Activity through Phosphorylation" "MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway" "6" "0" "1.218" "1.344" "1.223" "1.447" "1.234" "1.507" "1.412" "1.295" "1.464" "27.9" "34.0" "37.5" "34.1" "40.4" "34.4" "42.1" "39.4" "36.2" "40.9" "" "" "" "" "" "" "" "" "" "" "22.4" "24.5" "29.8" "22.9" "27.9" "25.8" "29.4" "28.8" "36.2" "33.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2465041974174611566" "False" "High" "IsMasterProtein" "Q96BT7" "Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens OX=9606 GN=ALKBH8 PE=1 SV=2" "0.000" "False" "6.623" "4" "2" "2" "2" "664" "75.2" "7.99" "6.16" "2" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08241, Pf09004, Pf13532" "91801" "ENSG00000137760" "ALKBH8" "B1Q2M0; B4DEF6; hsa:91801; Q8N989; Q96BT7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8769161245985835007" "False" "High" "IsMasterProtein" "Q9NYF3" "Protein FAM53C OS=Homo sapiens OX=9606 GN=FAM53C PE=1 SV=1" "0.000" "False" "6.622" "6" "2" "2" "2" "392" "43.1" "8.65" "7.76" "2" "transport" "nucleus" "" "Pf15242" "51307" "ENSG00000120709" "FAM53C" "B2RDJ5; D3DQB9; hsa:51307; Q9NYF3" "" "" "0" "0" "1.034" "1.043" "1.136" "1.038" "0.969" "1.191" "1.240" "1.111" "1.063" "227.9" "235.8" "237.6" "258.9" "236.6" "220.9" "271.5" "282.5" "253.3" "242.2" "" "" "" "" "" "" "" "" "" "" "183.1" "170.1" "188.8" "173.5" "163.6" "165.8" "190.1" "206.3" "253.3" "197.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1217035742207270021" "False" "High" "IsMasterProtein" "Q17RN3" "Protein FAM98C OS=Homo sapiens OX=9606 GN=FAM98C PE=1 SV=1" "0.000" "False" "6.613" "4" "1" "1" "1" "349" "37.3" "7.18" "3.27" "1" "" "other cell component" "" "Pf10239" "147965" "ENSG00000130244" "FAM98C" "A6NMW3; hsa:147965; Q17RN3; Q66K45" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1419370867446709471" "False" "High" "IsMasterProtein" "P42677" "Small ribosomal subunit protein eS27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "0.000" "False" "6.604" "23" "2" "2" "2" "84" "9.5" "9.45" "5.92" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "25" "0" "0.816" "0.817" "0.889" "1.078" "0.881" "1.050" "1.191" "1.026" "0.864" "105.6" "86.2" "86.2" "93.8" "113.9" "93.0" "110.9" "125.8" "108.4" "91.2" "" "" "" "" "" "" "" "" "" "" "84.8" "62.2" "68.5" "62.9" "78.7" "69.8" "77.7" "91.9" "108.4" "74.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45093919059166366" "False" "High" "IsMasterProtein" "O96018" "Amyloid-beta A4 precursor protein-binding family A member 3 OS=Homo sapiens OX=9606 GN=APBA3 PE=1 SV=1" "0.000" "False" "6.602" "5" "3" "3" "2" "575" "61.4" "4.94" "2.35" "3" "cell-cell signaling;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00595, Pf00640" "9546" "ENSG00000011132" "APBA3" "hsa:9546; O60483; O96018; Q9UPZ2" "Neurexins and neuroligins" "" "1" "0" "1.008" "1.149" "1.131" "1.086" "1.178" "0.875" "1.089" "1.351" "1.174" "131.4" "132.4" "151.0" "148.6" "142.6" "154.7" "115.0" "143.1" "177.5" "154.2" "" "" "" "" "" "" "" "" "" "" "105.5" "95.5" "119.9" "99.5" "98.6" "116.1" "80.5" "104.5" "177.5" "125.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5668169265399271149" "False" "High" "IsMasterProtein" "Q8N9N5" "Protein BANP OS=Homo sapiens OX=9606 GN=BANP PE=1 SV=3" "0.000" "False" "6.598" "5" "3" "3" "3" "519" "56.5" "5.49" "8.25" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf10523" "54971" "ENSG00000172530" "BANP" "A8MU25; A8MX25; B2RCF7; B4DNJ9; F5GZM0; hsa:54971; Q8N9N5; Q96GJ7; Q9NWY1" "Regulation of TP53 Activity through Association with Co-factors" "" "1" "0" "1.100" "1.076" "1.128" "1.129" "1.006" "1.010" "1.074" "1.091" "1.054" "210.2" "231.3" "226.1" "237.3" "237.3" "211.5" "212.3" "225.9" "229.3" "221.6" "" "" "" "" "" "" "" "" "" "" "168.9" "166.9" "179.6" "159.0" "164.1" "158.7" "148.7" "165.0" "229.3" "180.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263774820605261131" "False" "High" "IsMasterProtein" "Q9BTK6" "PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=PAGR1 PE=1 SV=1" "0.000" "False" "6.589" "7" "3" "3" "3" "254" "27.7" "4.46" "8.75" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf15364" "79447" "ENSG00000280789" "PAGR1" "A2ICR6; hsa:79447; Q9BTK6" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis" "16p11.2 proximal deletion syndrome; Kleefstra syndrome" "4" "0" "0.956" "1.021" "1.039" "1.002" "1.023" "0.997" "0.970" "1.007" "1.035" "445.8" "426.3" "455.2" "463.2" "446.8" "456.2" "444.4" "432.5" "449.0" "461.4" "" "" "" "" "" "" "" "" "" "" "358.1" "307.6" "361.6" "310.4" "309.0" "342.3" "311.1" "315.8" "449.0" "375.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058994257240808720" "False" "High" "IsMasterProtein" "Q9ULR5" "Polyadenylate-binding protein-interacting protein 2B OS=Homo sapiens OX=9606 GN=PAIP2B PE=1 SV=2" "0.000" "False" "6.583" "9" "1" "1" "1" "123" "14.2" "4.17" "4.06" "1" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "400961" "ENSG00000124374" "PAIP2B" "hsa:400961; Q9ULR5" "" "" "0" "0" "1.196" "1.073" "1.083" "1.002" "1.079" "0.976" "0.997" "1.095" "0.971" "109.3" "130.7" "117.3" "118.4" "109.5" "117.9" "106.7" "108.9" "119.7" "106.1" "" "" "" "" "" "" "" "" "" "" "87.8" "94.3" "93.2" "79.3" "75.7" "88.4" "74.7" "79.6" "119.7" "86.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4762125104752177783" "False" "High" "IsMasterProtein" "A0JNW5" "Bridge-like lipid transfer protein family member 3B OS=Homo sapiens OX=9606 GN=BLTP3B PE=1 SV=2" "0.000" "False" "6.579" "2" "3" "3" "3" "1464" "164.1" "6.32" "7.08" "3" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf12624" "23074" "ENSG00000111647" "BLTP3B" "A0JNW5; A0PJE5; hsa:23074; O75183; Q8NDL1; Q96C30; Q9BTS5; Q9H0F1" "RND2 GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201932136610495476" "False" "High" "IsMasterProtein" "Q8NHL6" "Leukocyte immunoglobulin-like receptor subfamily B member 1 OS=Homo sapiens OX=9606 GN=LILRB1 PE=1 SV=1" "0.000" "False" "6.576" "5" "2" "3" "2" "650" "70.8" "6.05" "0.00" "2" "cell cycle OR cell proliferation;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00047, Pf13895" "10859" "ENSG00000274669; ENSG00000277807" "LILRB1" "A2IXV4; A8MXT0; hsa:10859; O75024; O75025; Q8NHJ9; Q8NHK0; Q8NHL6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "1" "0" "0.686" "1.269" "1.036" "1.208" "1.149" "1.659" "0.943" "1.199" "1.110" "14.4" "9.9" "18.3" "14.9" "17.4" "16.6" "23.9" "13.6" "17.3" "16.0" "" "" "" "" "" "" "" "" "" "" "11.6" "7.1" "14.5" "10.0" "12.0" "12.4" "16.7" "9.9" "17.3" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2189379826665428433" "False" "High" "IsMasterProtein" "Q9UMY1" "U3 small nucleolar RNA-associated protein NOL7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2" "0.000" "False" "6.575" "6" "2" "3" "2" "257" "29.4" "9.67" "8.94" "2" "other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf08157" "51406" "ENSG00000225921" "NOL7" "hsa:51406; Q5T297; Q9UMY1; Q9Y3U7" "" "" "0" "0" "1.013" "1.102" "1.056" "1.051" "1.067" "0.846" "0.763" "0.783" "1.000" "206.3" "209.0" "227.4" "217.9" "216.8" "220.0" "174.4" "157.4" "161.5" "206.2" "" "" "" "" "" "" "" "" "" "" "165.7" "150.8" "180.6" "146.0" "149.9" "165.1" "122.1" "114.9" "161.5" "167.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4805951626840685734" "False" "High" "IsMasterProtein" "P50336" "Protoporphyrinogen oxidase OS=Homo sapiens OX=9606 GN=PPOX PE=1 SV=1" "0.000" "False" "6.564" "8" "3" "3" "3" "477" "50.7" "8.16" "5.68" "3" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01593" "5498" "ENSG00000143224" "PPOX" "D3DVG0; hsa:5498; P50336; Q5VTW8" "Heme biosynthesis" "Orexin receptor pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "4" "0" "1.022" "1.000" "1.028" "1.024" "0.931" "0.992" "0.943" "1.032" "1.026" "364.9" "373.1" "365.0" "375.1" "373.7" "339.8" "361.9" "344.1" "376.6" "374.3" "" "" "" "" "" "" "" "" "" "" "293.1" "269.2" "289.9" "251.3" "258.4" "254.9" "253.4" "251.3" "376.6" "304.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4040325489223208351" "False" "High" "IsMasterProtein" "O75486" "Transcription initiation protein SPT3 homolog OS=Homo sapiens OX=9606 GN=SUPT3H PE=1 SV=3" "0.000" "False" "6.563" "3" "1" "1" "1" "317" "35.8" "6.87" "4.11" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02269" "8464" "ENSG00000196284" "SUPT3H" "A6NKG9; B2R9Q5; hsa:8464; O75486; O76066; Q5TAV9; Q86VN7" "HATs acetylate histones" "" "1" "0" "1.029" "1.084" "1.070" "1.008" "0.911" "0.859" "1.150" "1.029" "1.047" "138.5" "142.5" "150.2" "148.2" "139.6" "126.2" "119.1" "159.3" "142.6" "145.0" "" "" "" "" "" "" "" "" "" "" "111.3" "102.9" "119.3" "99.3" "96.6" "94.7" "83.4" "116.3" "142.6" "117.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974219725755957834" "False" "High" "IsMasterProtein" "Q5HYJ3" "Protein FAM76B OS=Homo sapiens OX=9606 GN=FAM76B PE=1 SV=3" "0.000" "False" "6.558" "4" "1" "1" "1" "339" "38.7" "9.25" "3.66" "1" "" "nucleus" "" "Pf16046" "143684" "ENSG00000077458" "FAM76B" "B2R9C2; hsa:143684; Q5HYJ3; Q6PIU3; Q8TC53" "" "" "0" "0" "1.205" "1.061" "1.026" "1.018" "1.007" "1.049" "0.882" "1.021" "0.980" "82.3" "99.2" "87.3" "84.4" "83.7" "82.9" "86.3" "72.6" "84.0" "80.7" "" "" "" "" "" "" "" "" "" "" "66.1" "71.6" "69.3" "56.6" "57.9" "62.2" "60.5" "53.0" "84.0" "65.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4783796531760009514" "False" "High" "IsMasterProtein" "Q9Y228" "TRAF3-interacting JNK-activating modulator OS=Homo sapiens OX=9606 GN=TRAF3IP3 PE=1 SV=2" "0.000" "False" "6.549" "3" "2" "2" "2" "551" "63.6" "8.51" "6.66" "2" "other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle" "other molecular function" "" "80342" "ENSG00000009790" "TRAF3IP3" "A1L464; A6NIU9; hsa:80342; Q2YDB5; Q4VY06; Q7Z706; Q9Y228" "" "" "0" "0" "1.031" "0.979" "0.951" "0.987" "0.989" "0.927" "1.021" "1.053" "0.947" "337.7" "348.2" "330.6" "321.1" "333.5" "334.1" "312.9" "344.6" "355.7" "319.9" "" "" "" "" "" "" "" "" "" "" "271.2" "251.3" "262.6" "215.1" "230.6" "250.7" "219.1" "251.7" "355.7" "260.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286717889543307804" "False" "High" "IsMasterProtein" "O94889" "Kelch-like protein 18 OS=Homo sapiens OX=9606 GN=KLHL18 PE=1 SV=3" "0.000" "False" "6.548" "5" "3" "3" "3" "574" "63.6" "5.60" "5.24" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "23276" "ENSG00000114648" "KLHL18" "A8K612; hsa:23276; O94889; Q7Z3E8; Q8N125" "" "" "0" "0" "0.960" "1.075" "1.117" "0.987" "1.090" "0.976" "0.989" "1.124" "1.100" "83.5" "80.2" "89.8" "93.3" "82.4" "91.0" "81.5" "82.5" "93.8" "91.8" "" "" "" "" "" "" "" "" "" "" "67.1" "57.8" "71.3" "62.5" "57.0" "68.3" "57.0" "60.3" "93.8" "74.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-864787675804904831" "False" "High" "IsMasterProtein" "Q8NDN9" "RCC1 and BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCBTB1 PE=1 SV=1" "0.000" "False" "6.538" "2" "1" "1" "1" "531" "58.2" "6.47" "4.20" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "nucleus;other cell component" "" "Pf00415, Pf00651" "55213" "ENSG00000136144" "RCBTB1" "hsa:55213; Q8IY29; Q8NDN9; Q969U9" "" "Primary ovarian insufficiency" "1" "0" "1.029" "0.908" "1.039" "0.995" "1.036" "1.043" "1.054" "0.933" "0.965" "162.0" "166.7" "147.1" "168.4" "161.3" "167.9" "169.0" "170.8" "151.2" "156.4" "" "" "" "" "" "" "" "" "" "" "130.1" "120.3" "116.8" "112.8" "111.6" "126.0" "118.3" "124.8" "151.2" "127.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622932999208517122" "False" "High" "IsMasterProtein" "Q96HR8" "H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Homo sapiens OX=9606 GN=NAF1 PE=1 SV=2" "0.000" "False" "6.521" "4" "2" "2" "2" "494" "53.7" "4.87" "5.97" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04410" "92345" "ENSG00000145414" "NAF1" "D3DP28; E9PAZ2; hsa:92345; Q96HR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777002652342293914" "False" "High" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "0.000" "False" "6.511" "3" "3" "4" "2" "717" "81.6" "7.14" "11.94" "3" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855314221236891810" "False" "High" "IsMasterProtein" "Q5T0F9" "Coiled-coil and C2 domain-containing protein 1B OS=Homo sapiens OX=9606 GN=CC2D1B PE=1 SV=1" "0.000" "False" "6.507" "2" "2" "2" "1" "858" "94.2" "5.26" "6.40" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "200014" "ENSG00000154222" "CC2D1B" "hsa:200014; Q49AE8; Q5T0F8; Q5T0F9; Q5T0G0; Q6ZNQ1; Q96AP3; Q96I04; Q96JJ1" "Sealing of the nuclear envelope (NE) by ESCRT-III" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1954623923501006519" "False" "High" "IsMasterProtein" "Q8TBE9" "N-acylneuraminate-9-phosphatase OS=Homo sapiens OX=9606 GN=NANP PE=1 SV=1" "0.000" "False" "6.500" "7" "1" "1" "1" "248" "27.8" "6.40" "2.95" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00702" "140838" "ENSG00000170191" "NANP" "B3KP12; hsa:140838; Q5JYN8; Q8TBE9; Q8TE97; Q9Y3N0" "Sialic acid metabolism" "" "1" "0" "0.686" "0.712" "0.905" "0.985" "0.988" "0.819" "0.968" "0.620" "0.819" "30.3" "20.8" "21.6" "27.4" "29.9" "29.9" "24.8" "29.3" "18.8" "24.8" "" "" "" "" "" "" "" "" "" "" "24.3" "15.0" "17.1" "18.4" "20.6" "22.5" "17.4" "21.4" "18.8" "20.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9124413372325642778" "False" "High" "IsMasterProtein" "P12757" "Ski-like protein OS=Homo sapiens OX=9606 GN=SKIL PE=1 SV=2" "0.000" "False" "6.496" "5" "2" "2" "2" "684" "76.9" "7.11" "6.27" "2" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02437, Pf08782" "6498" "ENSG00000136603" "SKIL" "A6NGT1; B4DT50; hsa:6498; O00464; P12756; P12757; Q07501" "Downregulation of SMAD2/3:SMAD4 transcriptional activity" "Ectoderm differentiation; Lung fibrosis; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; TGF-beta receptor signaling in skeletal dysplasias; Orexin receptor pathway; TGF-beta receptor signaling" "8" "0" "1.035" "0.978" "1.067" "1.038" "1.032" "0.875" "0.919" "0.992" "1.077" "112.2" "116.2" "109.7" "119.7" "116.5" "115.9" "98.1" "103.1" "111.4" "120.8" "" "" "" "" "" "" "" "" "" "" "90.1" "83.8" "87.1" "80.2" "80.6" "86.9" "68.7" "75.3" "111.4" "98.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1860543310075142412" "False" "High" "IsMasterProtein" "Q02413" "Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2" "0.000" "False" "6.493" "2" "2" "2" "2" "1049" "113.7" "5.03" "3.89" "2" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00028, Pf01049" "1828" "ENSG00000134760" "DSG1" "B7Z845; hsa:1828; Q02413" "Neutrophil degranulation; Formation of the cornified envelope; RND2 GTPase cycle; RND3 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "" "6" "0" "0.775" "0.312" "0.655" "0.553" "0.364" "0.935" "0.456" "0.535" "0.587" "206.1" "159.7" "64.3" "135.0" "113.9" "75.0" "192.8" "94.1" "110.2" "121.0" "" "" "" "" "" "" "" "" "" "" "165.5" "115.3" "51.1" "90.4" "78.8" "56.3" "135.0" "68.7" "110.2" "98.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8184691105517631334" "False" "High" "IsMasterProtein" "Q9P035" "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2" "0.000" "False" "6.486" "3" "1" "1" "1" "362" "43.1" "8.94" "4.99" "1" "other metabolic processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus" "enzyme regulator activity;other molecular function" "Pf04387" "51495" "ENSG00000074696" "HACD3" "A0PJA1; B4DRF4; hsa:51495; Q280Z3; Q6PD63; Q8IUI5; Q8NC86; Q8NCB1; Q96T12; Q9NQA7; Q9P035" "Synthesis of very long-chain fatty acyl-CoAs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826640121646055106" "False" "High" "IsMasterProtein" "P13473" "Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2" "0.000" "False" "6.485" "5" "2" "3" "2" "410" "44.9" "5.63" "7.58" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3920" "ENSG00000005893" "LAMP2" "A8K4X5; D3DTF0; hsa:3920; P13473; Q16641; Q6Q3G8; Q96J30; Q99534; Q9UD93" "Neutrophil degranulation; Platelet degranulation ; Chaperone Mediated Autophagy" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Clock-controlled autophagy in bone metabolism" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3152037375536322199" "False" "High" "IsMasterProtein" "P68402" "Platelet-activating factor acetylhydrolase IB subunit alpha2 OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1" "0.000" "False" "6.479" "7" "2" "3" "2" "229" "25.6" "5.92" "8.72" "2" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13472" "5049" "ENSG00000168092" "PAFAH1B2" "A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; hsa:5049; O00687; P68402; Q29459; Q6IBR6" "COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "PAFAH1B1 copy number variation" "3" "0" "1.143" "1.106" "1.107" "1.074" "1.142" "1.124" "0.874" "1.055" "1.065" "145.4" "166.1" "160.8" "161.0" "156.2" "166.1" "163.5" "127.1" "153.4" "154.9" "" "" "" "" "" "" "" "" "" "" "116.8" "119.9" "127.8" "107.9" "108.0" "124.6" "114.5" "92.8" "153.4" "126.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5611096213630678464" "False" "High" "IsMasterProtein" "P11279" "Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3" "0.000" "False" "6.475" "5" "2" "3" "2" "417" "44.9" "8.75" "6.50" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3916" "ENSG00000185896" "LAMP1" "B4DWL3; hsa:3916; P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13" "Neutrophil degranulation" "" "1" "0" "1.005" "0.944" "1.092" "0.899" "0.938" "1.144" "0.996" "0.934" "1.004" "131.5" "132.2" "124.2" "143.6" "118.3" "123.4" "150.5" "131.0" "122.9" "132.1" "" "" "" "" "" "" "" "" "" "" "105.6" "95.4" "98.6" "96.2" "81.8" "92.6" "105.3" "95.7" "122.9" "107.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1100964520603987926" "False" "High" "IsMasterProtein" "Q13825" "Methylglutaconyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1" "0.000" "False" "6.442" "6" "2" "2" "2" "339" "35.6" "9.48" "6.42" "2" "other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00378" "549" "ENSG00000148090" "AUH" "B1ALV7; B1ALV8; hsa:549; Q13825; Q8WUE4" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4736505730620395534" "False" "High" "IsMasterProtein" "Q8N3Y1" "F-box/WD repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=FBXW8 PE=1 SV=2" "0.000" "False" "6.441" "2" "1" "1" "1" "598" "67.4" "5.67" "4.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00646" "26259" "ENSG00000174989" "FBXW8" "hsa:26259; Q8N3Y1; Q9UK95" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5448753331326211859" "False" "High" "IsMasterProtein" "Q9NX38" "Protein Abitram OS=Homo sapiens OX=9606 GN=ABITRAM PE=1 SV=1" "0.000" "False" "6.440" "9" "1" "1" "1" "181" "20.4" "7.93" "4.86" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf01597" "54942" "ENSG00000119328" "ABITRAM" "hsa:54942; Q5JTR0; Q5JTR1; Q9NX38" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580971408817382446" "False" "High" "IsMasterProtein" "O75956" "Cyclin-dependent kinase 2-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK2AP2 PE=1 SV=1" "0.000" "False" "6.431" "14" "2" "2" "2" "126" "13.1" "9.48" "6.66" "2" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf09806" "10263" "ENSG00000167797" "CDK2AP2" "hsa:10263; O75956" "" "" "0" "0" "1.029" "1.163" "1.101" "1.038" "1.113" "1.172" "1.121" "1.144" "1.042" "244.8" "251.9" "284.6" "269.4" "254.0" "272.4" "286.7" "274.3" "280.1" "255.1" "" "" "" "" "" "" "" "" "" "" "196.6" "181.8" "226.1" "180.5" "175.7" "204.4" "200.8" "200.3" "280.1" "207.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2168737288158195697" "False" "High" "IsMasterProtein" "Q9Y2K1" "Zinc finger and BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZBTB1 PE=1 SV=3" "0.000" "False" "6.423" "2" "1" "1" "1" "713" "82.0" "6.39" "4.01" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "22890" "ENSG00000126804" "ZBTB1" "A8K6S8; hsa:22890; Q86SW8; Q9Y2K1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1127806469772618408" "False" "High" "IsMasterProtein" "Q9Y4D8" "Probable E3 ubiquitin-protein ligase HECTD4 OS=Homo sapiens OX=9606 GN=HECTD4 PE=1 SV=5" "0.000" "False" "6.415" "1" "3" "3" "3" "3996" "439.1" "6.19" "6.71" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes" "other molecular function" "Pf00632" "" "" "HECTD4" "L8B0P6; Q3MJD5; Q6P0A0; Q7L530; Q8NB70; Q8WU73; Q96NT9; Q9NZS4; Q9UFT6; Q9Y4D8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531669477434534246" "False" "High" "IsMasterProtein" "Q9NX01" "Thioredoxin-like protein 4B OS=Homo sapiens OX=9606 GN=TXNL4B PE=1 SV=1" "0.000" "False" "6.414" "12" "2" "2" "2" "149" "17.0" "6.00" "5.62" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf02966" "54957" "ENSG00000140830" "TXNL4B" "D3DWS6; hsa:54957; Q9NX01" "" "" "0" "0" "1.021" "1.004" "1.010" "1.070" "0.914" "0.961" "1.039" "1.018" "0.990" "267.5" "273.1" "268.5" "270.2" "286.3" "244.5" "257.0" "277.9" "272.3" "264.7" "" "" "" "" "" "" "" "" "" "" "214.9" "197.1" "213.3" "181.0" "198.0" "183.5" "179.9" "202.9" "272.3" "215.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5520460410914984228" "False" "High" "IsMasterProtein" "Q9NSG2" "FIGNL1-interacting regulator of recombination and mitosis OS=Homo sapiens OX=9606 GN=FIRRM PE=1 SV=1" "0.000" "False" "6.412" "1" "1" "1" "1" "853" "96.5" "6.00" "2.96" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf14868" "55732" "ENSG00000000460" "FIRRM" "A6NFP1; B3KU42; hsa:55732; Q3KNQ1; Q9H8L5; Q9NSG2; Q9NVJ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417947325093162762" "False" "High" "IsMasterProtein" "Q49A26" "Cytokine-like nuclear factor N-PAC OS=Homo sapiens OX=9606 GN=GLYR1 PE=1 SV=4" "0.000" "False" "6.404" "5" "2" "2" "2" "553" "60.5" "9.17" "2.92" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf03446, Pf14833" "84656" "ENSG00000140632" "GLYR1" "B4DL47; C9JJ40; C9JJ60; hsa:84656; Q49A26; Q5U632; Q6P1Q2; Q6V3W7; Q9BTI1; Q9BXK2" "" "" "0" "0" "1.074" "1.099" "1.280" "1.603" "1.193" "1.221" "1.212" "1.119" "1.306" "59.3" "63.7" "65.1" "75.8" "95.0" "70.7" "72.4" "71.8" "66.3" "77.4" "" "" "" "" "" "" "" "" "" "" "47.6" "45.9" "51.7" "50.8" "65.7" "53.1" "50.7" "52.5" "66.3" "62.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514101839783017752" "False" "High" "IsMasterProtein" "Q9P021" "Cysteine-rich PDZ-binding protein OS=Homo sapiens OX=9606 GN=CRIPT PE=1 SV=1" "0.000" "False" "6.402" "19" "2" "3" "2" "101" "11.2" "9.47" "5.88" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10235" "9419" "ENSG00000119878" "CRIPT" "hsa:9419; Q9P021" "" "" "0" "0" "1.112" "0.979" "0.922" "0.977" "0.997" "0.897" "0.868" "0.913" "1.004" "281.3" "312.8" "275.5" "259.4" "274.9" "280.5" "252.3" "244.1" "256.7" "282.6" "" "" "" "" "" "" "" "" "" "" "226.0" "225.7" "218.8" "173.8" "190.1" "210.4" "176.7" "178.3" "256.7" "229.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2198906581928094734" "False" "High" "IsMasterProtein" "Q9BQC3" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1" "0.000" "False" "6.391" "5" "2" "2" "2" "489" "52.1" "5.53" "6.48" "2" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01866" "1802" "ENSG00000132768" "DPH2" "A8MVC9; B2RDE3; B4DNI8; hsa:1802; O60623; Q9BQC3" "Synthesis of diphthamide-EEF2" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2433784342189097750" "False" "High" "IsMasterProtein" "Q96FJ0" "AMSH-like protease OS=Homo sapiens OX=9606 GN=STAMBPL1 PE=1 SV=2" "0.000" "False" "6.388" "3" "1" "2" "1" "436" "49.8" "7.23" "7.95" "1" "protein metabolism;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "57559" "ENSG00000138134" "STAMBPL1" "B3KPA7; hsa:57559; Q5T9N4; Q5T9N9; Q7Z420; Q96FJ0; Q9P2H4" "Metalloprotease DUBs" "TGF-beta signaling pathway" "2" "0" "0.572" "0.882" "1.034" "0.787" "0.632" "0.857" "0.623" "0.905" "0.934" "19.8" "11.3" "17.5" "20.5" "15.6" "12.5" "17.0" "12.4" "18.0" "18.5" "" "" "" "" "" "" "" "" "" "" "15.9" "8.2" "13.9" "13.7" "10.8" "9.4" "11.9" "9.0" "18.0" "15.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808375425283248797" "False" "High" "IsMasterProtein" "Q13572" "Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens OX=9606 GN=ITPK1 PE=1 SV=2" "0.000" "False" "6.377" "5" "1" "1" "1" "414" "45.6" "6.16" "3.48" "1" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf05770, Pf17927" "3705" "ENSG00000100605; ENSG00000274958" "ITPK1" "hsa:3705; Q13572; Q9BTL6; Q9H2E7" "Factors involved in megakaryocyte development and platelet production; Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol" "2q37 copy number variation syndrome" "4" "0" "1.725" "1.603" "1.277" "1.719" "1.368" "1.252" "1.457" "0.985" "1.364" "12.6" "21.8" "20.3" "16.1" "21.7" "17.3" "15.8" "18.4" "12.4" "17.2" "" "" "" "" "" "" "" "" "" "" "10.2" "15.7" "16.1" "10.8" "15.0" "13.0" "11.1" "13.5" "12.4" "14.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946118222351064345" "False" "High" "IsMasterProtein" "Q6DD87" "Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4" "0.000" "False" "6.370" "9" "3" "3" "3" "382" "40.4" "7.96" "7.34" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465, Pf13912" "126208" "ENSG00000142409" "ZNF787" "A0A087WUD1; hsa:126208; O00455; Q6DD87" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7191429951444630095" "False" "High" "IsMasterProtein" "Q96RR4" "Calcium/calmodulin-dependent protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=CAMKK2 PE=1 SV=2" "0.000" "False" "6.370" "4" "2" "2" "2" "588" "64.7" "6.68" "4.22" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "10645" "ENSG00000110931" "CAMKK2" "A8K7Q7; hsa:10645; O94883; Q8IUG2; Q8IUG3; Q8N3I4; Q8WY03; Q8WY04; Q8WY05; Q8WY06; Q96RP1; Q96RP2; Q96RR3; Q96RR4; Q9BWE9; Q9UER3; Q9UES2; Q9Y5N2" "Activation of AMPK downstream of NMDARs; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Activation of RAC1 downstream of NMDARs" "AMP-activated protein kinase signaling; VEGFA-VEGFR2 signaling; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Orexin receptor pathway; Hippocampal synaptogenesis and neurogenesis" "10" "0" "0.823" "0.986" "0.569" "1.447" "0.938" "0.964" "0.896" "1.045" "1.174" "22.4" "18.4" "22.1" "12.7" "32.4" "21.0" "21.6" "20.0" "23.4" "26.3" "" "" "" "" "" "" "" "" "" "" "18.0" "13.3" "17.5" "8.5" "22.4" "15.7" "15.1" "14.6" "23.4" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2375435199137725135" "False" "High" "IsMasterProtein" "Q96MH2" "Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1" "0.000" "False" "6.362" "8" "3" "3" "2" "286" "32.4" "6.55" "7.81" "3" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "124790" "ENSG00000168517" "HEXIM2" "D3DX66; hsa:124790; Q96MH2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1889063708723088162" "False" "High" "IsMasterProtein" "O14772" "Fucose-1-phosphate guanylyltransferase OS=Homo sapiens OX=9606 GN=FPGT PE=1 SV=3" "0.000" "False" "6.343" "2" "1" "1" "1" "607" "68.0" "6.87" "4.46" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf07959" "8790" "ENSG00000254685" "FPGT" "A0A0A0MRP2; A6NMH3; B4DRX2; B4E2Y7; E9PNQ2; hsa:8790; O14772; Q8N5J7" "GDP-fucose biosynthesis" "" "1" "0" "1.003" "1.055" "1.249" "1.168" "0.987" "1.168" "1.069" "0.997" "1.048" "145.8" "146.2" "153.8" "182.1" "170.2" "144.0" "170.2" "155.8" "145.4" "152.7" "" "" "" "" "" "" "" "" "" "" "117.1" "105.5" "122.2" "122.0" "117.7" "108.0" "119.2" "113.8" "145.4" "124.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117029845093264208" "False" "High" "IsMasterProtein" "O75600" "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens OX=9606 GN=GCAT PE=1 SV=1" "0.000" "False" "6.343" "3" "1" "1" "1" "419" "45.3" "8.05" "4.38" "1" "other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00155" "23464" "ENSG00000100116" "GCAT" "E2QC23; hsa:23464; O75600; Q6ZWF1; Q96CA9" "Threonine catabolism" "" "1" "0" "1.037" "0.967" "1.180" "1.110" "1.167" "1.116" "1.215" "0.943" "0.946" "70.6" "73.2" "68.3" "83.2" "78.3" "82.3" "78.7" "85.7" "66.5" "66.7" "" "" "" "" "" "" "" "" "" "" "56.7" "52.8" "54.2" "55.8" "54.2" "61.8" "55.1" "62.6" "66.5" "54.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4882838083749459801" "False" "High" "IsMasterProtein" "O95199" "RCC1 and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RCBTB2 PE=1 SV=1" "0.000" "False" "6.341" "2" "1" "1" "1" "551" "60.3" "5.49" "3.56" "1" "" "other cell component" "enzyme regulator activity" "Pf00415, Pf00651" "1102" "ENSG00000136161" "RCBTB2" "B2RDW8; hsa:1102; O95199" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7985947186271226833" "False" "High" "IsMasterProtein" "Q9UPW0" "Forkhead box protein J3 OS=Homo sapiens OX=9606 GN=FOXJ3 PE=1 SV=2" "0.000" "False" "6.330" "2" "1" "2" "1" "622" "68.9" "7.09" "2.57" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250" "22887" "ENSG00000198815" "FOXJ3" "A7MBL7; A7MD18; D3DPW2; hsa:22887; Q9NSS7; Q9UPW0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721724367357589607" "False" "High" "IsMasterProtein" "Q6IPU0" "Centromere protein P OS=Homo sapiens OX=9606 GN=CENPP PE=1 SV=1" "0.000" "False" "6.320" "3" "1" "1" "1" "288" "33.1" "6.27" "3.58" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf13096" "401541" "ENSG00000188312; ENSG00000291348" "CENPP" "B3KRA5; B3KS17; hsa:401541; Q5T9F8; Q5T9F9; Q6IPU0" "Deposition of new CENPA-containing nucleosomes at the centromere; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5138409153076525613" "False" "High" "IsMasterProtein" "Q9HBI1" "Beta-parvin OS=Homo sapiens OX=9606 GN=PARVB PE=1 SV=1" "0.000" "False" "6.319" "3" "1" "1" "1" "364" "41.7" "6.73" "4.43" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00307" "29780" "ENSG00000188677" "PARVB" "B0QYM8; B0QYN1; B2R9X6; hsa:29780; Q5TGJ5; Q86X93; Q96PN1; Q9HBI1; Q9NSP7; Q9UGT3; Q9Y368; Q9Y3L6; Q9Y3L7" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Focal adhesion" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8343966935655594345" "False" "High" "IsMasterProtein" "P56385" "ATP synthase subunit e, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5ME PE=1 SV=2" "0.000" "False" "6.301" "14" "1" "1" "1" "69" "7.9" "9.35" "4.60" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05680" "521" "ENSG00000169020" "ATP5ME" "hsa:521; P56385; Q0D2L9" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "4" "0" "0.988" "0.953" "0.960" "0.947" "1.020" "1.088" "0.893" "0.948" "0.903" "388.3" "383.6" "370.1" "372.8" "367.5" "395.9" "422.3" "346.6" "368.2" "350.4" "" "" "" "" "" "" "" "" "" "" "311.9" "276.8" "294.0" "249.8" "254.2" "297.0" "295.7" "253.1" "368.2" "285.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3115652048582382832" "False" "High" "IsMasterProtein" "Q5D1E8" "Endoribonuclease ZC3H12A OS=Homo sapiens OX=9606 GN=ZC3H12A PE=1 SV=1" "0.000" "False" "6.290" "4" "2" "2" "2" "599" "65.7" "6.93" "5.35" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf11977, Pf18039, Pf18561" "80149" "ENSG00000163874" "ZC3H12A" "D3DPT0; hsa:80149; Q5D1E8; Q6I9Z1; Q9H5P1" "Regulation of CDH19 Expression and Function" "IL-18 signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1984767701943514611" "False" "High" "IsMasterProtein" "Q9NQS1" "Cell death regulator Aven OS=Homo sapiens OX=9606 GN=AVEN PE=1 SV=1" "0.000" "False" "6.286" "10" "3" "3" "3" "362" "38.5" "4.98" "6.71" "3" "other biological processes" "other membranes;cytosol;other cell component" "" "" "57099" "ENSG00000169857" "AVEN" "hsa:57099; Q9NQS1" "Regulation of the apoptosome activity" "" "2" "0" "0.964" "0.937" "1.155" "1.225" "0.963" "0.959" "0.976" "0.981" "1.298" "27.9" "26.9" "26.2" "32.3" "34.2" "26.9" "26.8" "27.3" "27.4" "36.3" "" "" "" "" "" "" "" "" "" "" "22.4" "19.4" "20.8" "21.6" "23.7" "20.2" "18.8" "19.9" "27.4" "29.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1338482148380343385" "False" "High" "IsMasterProtein" "Q07890" "Son of sevenless homolog 2 OS=Homo sapiens OX=9606 GN=SOS2 PE=1 SV=2" "0.000" "False" "6.283" "1" "2" "2" "1" "1332" "152.9" "6.84" "4.51" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf00617, Pf00618, Pf00621" "6655" "ENSG00000100485" "SOS2" "B7ZKT6; D3DSB4; hsa:6655; Q07890; Q15503; Q17RN1" "Interleukin-15 signaling; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; Activation of RAC1" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; MAPK pathway in congenital thyroid cancer; Regulation of actin cytoskeleton; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent)" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037081558044957936" "False" "High" "IsMasterProtein" "P21796" "Non-selective voltage-gated ion channel VDAC1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2" "0.000" "False" "6.281" "6" "2" "2" "2" "283" "30.8" "8.54" "5.52" "2" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01459" "7416" "ENSG00000213585" "VDAC1" "B3KVK4; D3DQ93; P21796; Q5FVE7; Q9UIQ5; Q9UPL0" "Ub-specific processing proteases; Pyruvate metabolism; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy; Mitochondrial calcium ion transport" "Alzheimer's disease and miRNA effects; Alzheimer's disease; Arsenic metabolism and reactive oxygen species generation; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "10" "0" "1.027" "1.174" "1.270" "1.161" "1.153" "1.248" "0.878" "1.140" "1.120" "458.1" "470.4" "537.7" "582.1" "532.0" "528.4" "571.6" "402.5" "522.2" "513.3" "" "" "" "" "" "" "" "" "" "" "368.0" "339.4" "427.1" "390.0" "368.0" "396.4" "400.2" "293.9" "522.2" "417.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6446892440911293889" "False" "High" "IsMasterProtein" "Q5JR59" "Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens OX=9606 GN=MTUS2 PE=1 SV=3" "0.000" "False" "6.248" "1" "1" "1" "1" "1369" "150.1" "6.68" "4.24" "1" "" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "23281" "ENSG00000132938" "MTUS2" "A7E292; B4DF81; O94872; Q08E97; Q5JQR3; Q5JR59; Q8N5E2" "" "" "0" "0" "0.975" "0.896" "1.201" "1.050" "1.044" "1.029" "1.034" "1.013" "0.886" "122.1" "119.1" "109.4" "146.7" "128.2" "127.5" "125.7" "126.2" "123.8" "108.2" "" "" "" "" "" "" "" "" "" "" "98.1" "86.0" "86.9" "98.3" "88.7" "95.7" "88.0" "92.2" "123.8" "88.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7363542337896916296" "False" "High" "IsMasterProtein" "Q8NHP6" "Motile sperm domain-containing protein 2 OS=Homo sapiens OX=9606 GN=MOSPD2 PE=1 SV=1" "0.000" "False" "6.234" "4" "2" "2" "2" "518" "59.7" "5.96" "5.64" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00635, Pf00650" "158747" "ENSG00000130150" "MOSPD2" "hsa:158747; Q8N3H2; Q8NA83; Q8NHP6" "Neutrophil degranulation; RHOD GTPase cycle" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4245870540652335533" "False" "High" "IsMasterProtein" "Q8N8N7" "Prostaglandin reductase 2 OS=Homo sapiens OX=9606 GN=PTGR2 PE=1 SV=1" "0.000" "False" "6.212" "5" "1" "2" "1" "351" "38.5" "5.41" "8.99" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00107, Pf16884" "145482" "ENSG00000140043" "PTGR2" "hsa:145482; Q3L8A4; Q6MZH8; Q8N8N7" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence" "4" "0" "1.184" "1.003" "1.347" "1.297" "1.211" "1.132" "0.993" "1.029" "1.040" "93.1" "110.2" "93.3" "125.4" "120.7" "112.7" "105.3" "92.5" "95.8" "96.8" "" "" "" "" "" "" "" "" "" "" "74.7" "79.5" "74.1" "84.0" "83.5" "84.5" "73.7" "67.5" "95.8" "78.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869722740218249638" "False" "High" "IsMasterProtein" "Q9Y6M4" "Casein kinase I isoform gamma-3 OS=Homo sapiens OX=9606 GN=CSNK1G3 PE=1 SV=2" "0.000" "False" "6.212" "4" "2" "2" "2" "447" "51.4" "9.22" "6.02" "2" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12605" "1456" "ENSG00000151292" "CSNK1G3" "A8K040; B4DSH2; B7Z9Q4; E7EVD0; hsa:1456; Q86WZ7; Q9Y6M3; Q9Y6M4" "" "Hedgehog signaling pathway" "1" "0" "0.956" "0.949" "1.068" "1.128" "1.049" "1.115" "1.118" "1.034" "0.939" "163.9" "156.6" "155.5" "175.0" "184.8" "172.0" "182.8" "183.2" "169.4" "153.8" "" "" "" "" "" "" "" "" "" "" "131.6" "113.0" "123.5" "117.2" "127.8" "129.0" "128.0" "133.8" "169.4" "125.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4899059138870577225" "False" "High" "IsMasterProtein" "Q7Z7F7" "Large ribosomal subunit protein mL55 OS=Homo sapiens OX=9606 GN=MRPL55 PE=1 SV=1" "0.000" "False" "6.208" "11" "1" "2" "1" "128" "15.1" "11.15" "7.29" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09776" "128308" "ENSG00000162910" "MRPL55" "hsa:128308; Q5TBY3; Q5TBY6; Q6UWI8; Q7Z7F7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.868" "0.835" "1.009" "0.985" "1.001" "1.051" "0.916" "0.920" "1.059" "44.2" "38.3" "36.9" "44.6" "43.5" "44.2" "46.4" "40.4" "40.6" "46.8" "" "" "" "" "" "" "" "" "" "" "35.5" "27.7" "29.3" "29.9" "30.1" "33.2" "32.5" "29.5" "40.6" "38.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8998868825977106546" "False" "High" "IsMasterProtein" "Q9H3Z4" "DnaJ homolog subfamily C member 5 OS=Homo sapiens OX=9606 GN=DNAJC5 PE=1 SV=1" "0.000" "False" "6.193" "18" "2" "2" "2" "198" "22.1" "5.07" "6.15" "2" "cell-cell signaling;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00226" "80331" "ENSG00000101152" "DNAJC5" "A8K0M0; B3KY68; E1P5G8; hsa:80331; Q9H3Z4; Q9H3Z5; Q9H7H2" "Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4949581647878709913" "False" "High" "IsMasterProtein" "Q7Z7A1" "Centriolin OS=Homo sapiens OX=9606 GN=CNTRL PE=1 SV=2" "0.000" "False" "6.168" "1" "2" "2" "2" "2325" "268.7" "5.55" "5.11" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf14580" "11064" "ENSG00000119397" "CNTRL" "A2A2Y1; B2RP67; hsa:11064; Q3MN79; Q5FWF8; Q5JVD0; Q6MZR3; Q6PKC1; Q7Z7A1; Q8TEP3; Q9Y489" "Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459567774335388570" "False" "High" "IsMasterProtein" "Q6ZRI6" "Uncharacterized protein C15orf39 OS=Homo sapiens OX=9606 GN=C15orf39 PE=1 SV=3" "0.000" "False" "6.161" "2" "2" "2" "2" "1047" "110.6" "7.64" "5.57" "2" "" "cytosol" "" "Pf17663" "56905" "ENSG00000167173" "C15orf39" "B3KWI3; C9J888; hsa:56905; Q6ZRI6; Q71JB1; Q7L3S0; Q8N3F2; Q96FB6; Q9NTU5" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.891" "0.961" "0.990" "0.876" "0.983" "0.937" "0.900" "0.991" "0.969" "166.7" "148.5" "160.2" "165.0" "146.0" "163.8" "156.1" "149.9" "165.1" "161.6" "" "" "" "" "" "" "" "" "" "" "133.9" "107.2" "127.3" "110.5" "101.0" "122.9" "109.3" "109.5" "165.1" "131.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1508097308804950005" "False" "High" "IsMasterProtein" "Q9NRP2" "COX assembly mitochondrial protein 2 homolog OS=Homo sapiens OX=9606 GN=CMC2 PE=1 SV=1" "0.000" "False" "6.159" "22" "2" "3" "2" "79" "9.5" "7.87" "6.36" "2" "" "mitochondrion" "" "Pf08583" "56942" "ENSG00000103121; ENSG00000291948" "CMC2" "D3DUK6; hsa:56942; Q9NRP2" "Mitochondrial protein import" "" "1" "0" "2.478" "1.018" "1.606" "1.477" "2.161" "1.405" "1.059" "1.581" "1.484" "190.3" "471.4" "193.7" "305.6" "281.0" "411.2" "267.2" "201.4" "300.7" "282.4" "" "" "" "" "" "" "" "" "" "" "152.8" "340.2" "153.9" "204.8" "194.3" "308.5" "187.1" "147.1" "300.7" "229.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1463147851844743344" "False" "High" "IsMasterProtein" "Q9HCG8" "Pre-mRNA-splicing factor CWC22 homolog OS=Homo sapiens OX=9606 GN=CWC22 PE=1 SV=3" "0.000" "False" "6.152" "4" "3" "3" "3" "908" "105.4" "7.03" "4.01" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf02847, Pf02854" "57703" "ENSG00000163510" "CWC22" "hsa:57703; Q05DC2; Q4G135; Q52LF0; Q6PEX2; Q7Z6I0; Q9H5L3; Q9H6Q6; Q9HCG8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.081" "1.099" "1.238" "0.992" "1.066" "1.380" "1.288" "1.033" "1.055" "41.0" "44.3" "45.0" "50.7" "40.6" "43.7" "56.5" "52.7" "42.3" "43.2" "" "" "" "" "" "" "" "" "" "" "32.9" "32.0" "35.8" "34.0" "28.1" "32.8" "39.6" "38.5" "42.3" "35.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5069681427650443820" "False" "High" "IsMasterProtein" "Q8IX07" "Zinc finger protein ZFPM1 OS=Homo sapiens OX=9606 GN=ZFPM1 PE=1 SV=2" "0.000" "False" "6.149" "2" "2" "2" "2" "1006" "104.8" "7.87" "5.44" "2" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf21182" "161882" "ENSG00000179588" "ZFPM1" "hsa:161882; Q8IX07" "Factors involved in megakaryocyte development and platelet production; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "" "2" "0" "1.097" "0.834" "0.922" "0.916" "0.721" "0.770" "1.126" "1.090" "0.725" "16.6" "18.2" "13.9" "15.3" "15.2" "12.0" "12.8" "18.7" "18.1" "12.1" "" "" "" "" "" "" "" "" "" "" "13.3" "13.2" "11.0" "10.3" "10.5" "9.0" "9.0" "13.7" "18.1" "9.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8176798073003434309" "False" "High" "IsMasterProtein" "Q08554" "Desmocollin-1 OS=Homo sapiens OX=9606 GN=DSC1 PE=1 SV=2" "0.000" "False" "6.145" "2" "1" "1" "1" "894" "99.9" "5.43" "3.92" "1" "cell adhesion" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00028, Pf08758" "1823" "ENSG00000134765" "DSC1" "hsa:1823; Q08554; Q9HB01" "Neutrophil degranulation; Formation of the cornified envelope" "VEGFA-VEGFR2 signaling" "4" "0" "1.116" "0.886" "1.046" "1.189" "1.092" "1.361" "1.047" "1.137" "1.070" "115.8" "129.2" "102.6" "121.2" "137.7" "126.5" "157.6" "121.3" "131.7" "123.9" "" "" "" "" "" "" "" "" "" "" "93.0" "93.2" "81.5" "81.2" "95.2" "94.9" "110.3" "88.6" "131.7" "100.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003059613136436384" "False" "High" "IsMasterProtein" "P11217" "Glycogen phosphorylase, muscle form OS=Homo sapiens OX=9606 GN=PYGM PE=1 SV=6" "0.000" "False" "6.141" "3" "2" "3" "1" "842" "97.0" "7.03" "9.55" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00343" "5837" "ENSG00000068976" "PYGM" "A0AVK1; A6NDY6; hsa:5837; P11217" "Glycogen breakdown (glycogenolysis)" "Glycogen synthesis and degradation" "2" "0" "0.991" "0.887" "1.179" "0.927" "0.881" "0.941" "0.924" "0.933" "1.036" "125.7" "124.5" "111.5" "148.2" "116.5" "110.8" "118.2" "116.1" "117.2" "130.2" "" "" "" "" "" "" "" "" "" "" "100.9" "89.9" "88.6" "99.3" "80.6" "83.1" "82.8" "84.8" "117.2" "105.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5305151798806457032" "False" "High" "IsMasterProtein" "Q9UJ68" "Mitochondrial peptide methionine sulfoxide reductase OS=Homo sapiens OX=9606 GN=MSRA PE=1 SV=1" "0.000" "False" "6.135" "7" "2" "2" "2" "235" "26.1" "8.09" "6.10" "2" "protein metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01625" "4482" "ENSG00000175806; ENSG00000285250" "MSRA" "E9PAS8; hsa:4482; Q52TC4; Q549N4; Q66MI7; Q9UJ68" "Protein repair" "Sulindac metabolic pathway; Methionine de novo and salvage pathway; 8p23.1 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5112619369075693620" "False" "High" "IsMasterProtein" "Q02338" "D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=BDH1 PE=1 SV=3" "0.000" "False" "6.135" "3" "1" "1" "1" "343" "38.1" "8.95" "3.94" "1" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00106" "622" "ENSG00000161267; ENSG00000275544" "BDH1" "D3DXC0; hsa:622; Q02338; Q96ET1; Q9BRZ4" "Mitochondrial protein degradation; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "" "3" "0" "0.959" "1.017" "1.104" "1.093" "1.101" "1.138" "1.111" "1.061" "1.019" "109.3" "104.8" "111.2" "120.6" "119.5" "120.3" "124.4" "121.5" "116.0" "111.3" "" "" "" "" "" "" "" "" "" "" "87.8" "75.6" "88.3" "80.8" "82.6" "90.3" "87.1" "88.7" "116.0" "90.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4411072855446400187" "False" "High" "IsMasterProtein" "Q9UHA2" "SS18-like protein 2 OS=Homo sapiens OX=9606 GN=SS18L2 PE=1 SV=1" "0.000" "False" "6.128" "13" "1" "1" "1" "77" "8.8" "5.83" "4.01" "1" "other biological processes" "" "other molecular function" "Pf05030" "51188" "ENSG00000008324" "SS18L2" "B2R5L1; hsa:51188; Q9UHA2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8066723703653811047" "False" "High" "IsMasterProtein" "P53814" "Smoothelin OS=Homo sapiens OX=9606 GN=SMTN PE=1 SV=7" "0.000" "False" "6.118" "2" "2" "2" "2" "917" "99.0" "9.07" "5.76" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf12510" "6525" "ENSG00000183963" "SMTN" "hsa:6525; O00569; O95769; O95937; P53814; Q8N4H8; Q8WWW1; Q8WWW2; Q9P1S8; Q9UIT1; Q9UIT2" "" "" "0" "0" "1.056" "0.918" "1.201" "1.339" "0.964" "1.288" "1.499" "1.362" "1.057" "48.1" "50.8" "44.1" "57.8" "64.4" "46.3" "61.9" "72.1" "65.5" "50.8" "" "" "" "" "" "" "" "" "" "" "38.6" "36.6" "35.1" "38.7" "44.5" "34.8" "43.4" "52.6" "65.5" "41.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6723656292985318404" "False" "High" "IsMasterProtein" "Q9Y255" "PRELI domain-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=PRELID1 PE=1 SV=1" "0.000" "False" "6.117" "8" "2" "2" "2" "219" "25.2" "9.54" "5.47" "2" "cell organization and biogenesis;transport;other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf04707" "27166" "ENSG00000169230" "PRELID1" "B2R5F7; D6RD25; hsa:27166; Q549N2; Q9UI13; Q9UJS9; Q9Y255" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "5q35 copy number variation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1997120607862774840" "False" "High" "IsMasterProtein" "O00189" "AP-4 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP4M1 PE=1 SV=2" "0.000" "False" "6.110" "5" "2" "2" "2" "453" "49.9" "7.20" "6.27" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00928, Pf01217" "9179" "ENSG00000221838" "AP4M1" "D6W5U1; hsa:9179; O00189; Q8WV65; Q9UHK9" "Lysosome Vesicle Biogenesis" "" "1" "0" "1.050" "1.003" "1.014" "1.043" "1.069" "1.017" "1.091" "1.081" "1.054" "125.3" "131.6" "125.6" "127.0" "130.7" "133.9" "127.3" "136.6" "135.4" "132.0" "" "" "" "" "" "" "" "" "" "" "100.6" "94.9" "99.8" "85.1" "90.4" "100.5" "89.2" "99.8" "135.4" "107.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7220942742966589684" "False" "High" "IsMasterProtein" "P01130" "Low-density lipoprotein receptor OS=Homo sapiens OX=9606 GN=LDLR PE=1 SV=1" "0.000" "False" "6.109" "2" "2" "2" "2" "860" "95.3" "5.05" "6.01" "2" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00057, Pf00058, Pf14670" "3949" "ENSG00000130164" "LDLR" "B4DII3; B4DJZ8; B4DR00; B4DTQ3; C0JYY8; H0YLU8; H0YNT7; hsa:3949; P01130; Q53ZD9; Q59FQ1; Q9UDH7" "Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Cholesterol metabolism; Enterocyte cholesterol metabolism; DNA damage response (only ATM dependent)" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3254611339716425510" "False" "High" "IsMasterProtein" "Q96FE7" "Phosphoinositide-3-kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PIK3IP1 PE=1 SV=2" "0.000" "False" "6.100" "4" "1" "1" "1" "263" "28.2" "5.01" "4.04" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00051" "113791" "ENSG00000100100" "PIK3IP1" "B4DRR9; D1MEI0; hsa:113791; O00318; Q49A94; Q86YW2; Q8NCJ9; Q96FE7" "" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1233208040052068453" "False" "High" "IsMasterProtein" "Q5T2R2" "All trans-polyprenyl-diphosphate synthase PDSS1 OS=Homo sapiens OX=9606 GN=PDSS1 PE=1 SV=1" "0.000" "False" "6.093" "5" "2" "2" "2" "415" "46.2" "9.00" "7.10" "2" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00348" "23590" "ENSG00000148459" "PDSS1" "hsa:23590; Q53F75; Q5T2R2; Q6P473; Q86WQ8; Q9Y2W5" "Ubiquinol biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2426417921420304223" "False" "High" "IsMasterProtein" "Q13523" "Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRP4K PE=1 SV=3" "0.000" "False" "6.089" "2" "2" "2" "2" "1007" "116.9" "10.26" "6.34" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8899" "ENSG00000112739" "PRPF4B" "A8K5C9; hsa:8899; Q13523; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.952" "1.150" "1.000" "1.015" "1.235" "1.044" "0.897" "1.037" "1.211" "116.0" "110.4" "133.4" "116.0" "117.7" "143.3" "121.1" "104.1" "120.3" "140.5" "" "" "" "" "" "" "" "" "" "" "93.2" "79.7" "106.0" "77.7" "81.4" "107.5" "84.8" "76.0" "120.3" "114.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773466302739239443" "False" "High" "IsMasterProtein" "Q8IYA6" "Cytoskeleton-associated protein 2-like OS=Homo sapiens OX=9606 GN=CKAP2L PE=1 SV=4" "0.000" "False" "6.081" "2" "1" "1" "1" "745" "83.5" "9.83" "3.47" "1" "" "cytosol;cytoskeleton" "" "Pf15297" "150468" "ENSG00000169607" "CKAP2L" "A8K915; B4DZE3; B7ZAC6; F5H0M5; hsa:150468; Q53QF8; Q53RS8; Q8IYA6; Q8N1J8" "" "2q13 copy number variation syndrome" "1" "0" "1.477" "1.279" "1.466" "1.327" "0.902" "1.686" "2.278" "1.788" "1.378" "17.9" "26.4" "22.8" "26.2" "23.7" "16.1" "30.1" "40.7" "31.9" "24.6" "" "" "" "" "" "" "" "" "" "" "14.3" "19.0" "18.1" "17.5" "16.4" "12.1" "21.1" "29.7" "31.9" "20.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535495802418594220" "False" "High" "IsMasterProtein" "Q9H081" "Protein MIS12 homolog OS=Homo sapiens OX=9606 GN=MIS12 PE=1 SV=1" "0.000" "False" "6.069" "7" "1" "1" "1" "205" "24.1" "5.69" "5.85" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05859" "79003" "ENSG00000167842" "MIS12" "hsa:79003; Q96N24; Q9H081" "Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2540636687362609874" "False" "High" "IsMasterProtein" "O94768" "Serine/threonine-protein kinase 17B OS=Homo sapiens OX=9606 GN=STK17B PE=1 SV=1" "0.000" "False" "6.064" "5" "2" "2" "2" "372" "42.3" "5.25" "5.82" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9262" "ENSG00000081320" "STK17B" "hsa:9262; O94768" "" "" "0" "0" "1.133" "1.261" "0.961" "0.735" "0.911" "1.008" "0.837" "1.129" "0.962" "40.1" "45.4" "50.5" "38.5" "29.4" "36.5" "40.4" "33.5" "45.2" "38.6" "" "" "" "" "" "" "" "" "" "" "32.2" "32.8" "40.1" "25.8" "20.4" "27.4" "28.3" "24.5" "45.2" "31.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7087591643624783243" "False" "High" "IsMasterProtein" "Q9H3C7" "Gametogenetin-binding protein 2 OS=Homo sapiens OX=9606 GN=GGNBP2 PE=1 SV=1" "0.000" "False" "6.059" "3" "2" "2" "2" "697" "79.0" "6.38" "3.32" "2" "developmental processes;other biological processes" "nucleus;other cell component" "" "" "79893" "ENSG00000275099; ENSG00000278311" "GGNBP2" "B2RPK7; hsa:79893; Q96T90; Q9GZR8; Q9H3C7; Q9H767" "" "17q12 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-739436223450923494" "False" "High" "IsMasterProtein" "P28749" "Retinoblastoma-like protein 1 OS=Homo sapiens OX=9606 GN=RBL1 PE=1 SV=3" "0.000" "False" "6.051" "2" "2" "2" "2" "1068" "120.8" "7.50" "6.47" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5933" "ENSG00000080839" "RBL1" "A8K2W5; hsa:5933; P28749; Q4VXA0; Q8N5K6; Q9H1L5; Q9H1M1" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Transcription of E2F targets under negative control by DREAM complex; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; DYRK1A involvement regarding cell proliferation in brain development; ID signaling pathway" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5843152145544884275" "False" "High" "IsMasterProtein" "Q6KC79" "Nipped-B-like protein OS=Homo sapiens OX=9606 GN=NIPBL PE=1 SV=2" "0.000" "False" "6.040" "1" "2" "2" "2" "2804" "315.9" "7.91" "2.87" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12765, Pf12830" "25836" "ENSG00000164190" "NIPBL" "hsa:25836; Q6KC79; Q6KCD6; Q6N080; Q6ZT92; Q7Z2E6; Q8N4M5; Q9Y6Y3; Q9Y6Y4" "Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "3" "0" "1.291" "0.954" "1.233" "0.964" "1.130" "1.166" "0.964" "1.153" "1.226" "44.9" "58.0" "42.9" "55.4" "43.3" "50.8" "52.4" "43.3" "51.8" "55.1" "" "" "" "" "" "" "" "" "" "" "36.1" "41.9" "34.1" "37.1" "30.0" "38.1" "36.7" "31.6" "51.8" "44.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4545350310808249062" "False" "High" "IsMasterProtein" "Q4AE62" "tRNA-queuosine alpha-mannosyltransferase OS=Homo sapiens OX=9606 GN=GTDC1 PE=1 SV=1" "0.000" "False" "6.038" "6" "2" "2" "2" "458" "52.6" "7.25" "6.78" "2" "" "" "other molecular function" "Pf00534, Pf12038" "79712" "ENSG00000121964" "GTDC1" "A0A087X2H5; A8K5P2; D3DP81; G1UFN1; G5EA49; H7BYJ5; hsa:79712; Q4AE62; Q53SM7; Q53TC5; Q6P7E7; Q6PJB6; Q6WKW6; Q9HAE5" "" "" "0" "0" "0.985" "0.929" "1.008" "0.960" "0.928" "1.037" "1.016" "0.886" "0.967" "231.2" "227.6" "214.7" "233.0" "221.8" "214.6" "239.7" "234.7" "204.8" "223.5" "" "" "" "" "" "" "" "" "" "" "185.7" "164.3" "170.6" "156.1" "153.4" "161.0" "167.8" "171.4" "204.8" "181.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325955711170823186" "False" "High" "IsMasterProtein" "Q9UIF9" "Bromodomain adjacent to zinc finger domain protein 2A OS=Homo sapiens OX=9606 GN=BAZ2A PE=1 SV=4" "0.000" "False" "6.034" "1" "2" "2" "2" "1905" "211.1" "6.64" "5.64" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf01429, Pf02791, Pf15612, Pf15613" "11176" "ENSG00000076108" "BAZ2A" "B3KN66; hsa:11176; O00536; O15030; Q68DI8; Q96H26; Q9UIF9" "NoRC negatively regulates rRNA expression" "" "1" "0" "0.816" "1.306" "1.279" "0.811" "0.821" "1.133" "1.178" "1.344" "1.113" "34.3" "28.0" "44.8" "43.8" "27.8" "28.1" "38.8" "40.4" "46.1" "38.1" "" "" "" "" "" "" "" "" "" "" "27.5" "20.2" "35.6" "29.4" "19.2" "21.1" "27.2" "29.5" "46.1" "31.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4345096920380690584" "False" "High" "IsMasterProtein" "Q68CZ6" "HAUS augmin-like complex subunit 3 OS=Homo sapiens OX=9606 GN=HAUS3 PE=1 SV=1" "0.000" "False" "6.031" "3" "2" "2" "2" "603" "69.6" "5.55" "3.53" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf14932" "79441" "ENSG00000214367" "HAUS3" "B4DF64; hsa:79441; O43606; Q68CZ6; Q8TAZ5; Q9BTJ9" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.137" "1.206" "0.966" "1.165" "1.194" "0.969" "1.086" "1.234" "1.203" "135.5" "154.0" "163.4" "130.9" "157.8" "161.7" "131.3" "147.1" "167.2" "162.9" "" "" "" "" "" "" "" "" "" "" "108.8" "111.1" "129.8" "87.7" "109.1" "121.3" "91.9" "107.4" "167.2" "132.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7126274617434140537" "False" "High" "IsMasterProtein" "Q9UPV9" "Trafficking kinesin-binding protein 1 OS=Homo sapiens OX=9606 GN=TRAK1 PE=1 SV=1" "0.000" "False" "6.029" "1" "1" "1" "1" "953" "106.0" "5.85" "3.96" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf04849, Pf12448" "22906" "ENSG00000182606" "TRAK1" "E9PDS2; hsa:22906; J3KNT7; Q63HR0; Q659B5; Q96B69; Q9UPV9" "Signaling by BRAF and RAF1 fusions; RHOT2 GTPase cycle; RHOT1 GTPase cycle" "Vitamin D receptor pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6706033477145549001" "False" "High" "IsMasterProtein" "A7XYQ1" "Sine oculis-binding protein homolog OS=Homo sapiens OX=9606 GN=SOBP PE=1 SV=2" "0.000" "False" "6.023" "3" "1" "1" "1" "873" "92.6" "7.68" "3.82" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf15279" "55084" "ENSG00000112320" "SOBP" "A7XYQ1; B0QZ12; hsa:55084; Q5BJD4; Q8N2B2" "" "" "0" "0" "1.219" "0.945" "1.166" "1.053" "0.974" "0.806" "0.679" "0.893" "0.885" "24.1" "29.4" "22.8" "28.1" "25.4" "23.5" "19.4" "16.3" "21.5" "21.3" "" "" "" "" "" "" "" "" "" "" "19.4" "21.2" "18.1" "18.8" "17.6" "17.6" "13.6" "11.9" "21.5" "17.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502838028789951010" "False" "High" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "0.000" "False" "6.021" "16" "2" "3" "2" "102" "11.2" "9.32" "8.09" "2" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "1.258" "1.168" "1.313" "1.551" "1.362" "1.371" "1.469" "1.348" "1.461" "84.1" "105.9" "98.3" "110.5" "130.5" "114.6" "115.3" "123.6" "113.4" "123.0" "" "" "" "" "" "" "" "" "" "" "67.6" "76.4" "78.1" "74.0" "90.3" "86.0" "80.7" "90.3" "113.4" "100.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7676030556128945513" "False" "High" "IsMasterProtein" "Q8WXX7" "Autism susceptibility gene 2 protein OS=Homo sapiens OX=9606 GN=AUTS2 PE=1 SV=1" "0.000" "False" "6.019" "2" "3" "3" "3" "1259" "138.9" "9.38" "3.30" "3" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15336" "26053" "ENSG00000158321" "AUTS2" "A4D1Y9; L7QET3; L7QF75; Q5D049; Q6PJU5; Q8WXX7; Q9Y4F2" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "" "1" "0" "0.782" "1.203" "1.791" "1.025" "0.895" "1.285" "1.312" "1.191" "1.004" "13.5" "10.5" "16.2" "24.2" "13.8" "12.1" "17.3" "17.7" "16.1" "13.5" "" "" "" "" "" "" "" "" "" "" "10.8" "7.6" "12.9" "16.2" "9.6" "9.1" "12.1" "12.9" "16.1" "11.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3805240560895531655" "False" "High" "IsMasterProtein" "Q15532" "Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3" "0.000" "False" "6.018" "2" "1" "3" "1" "418" "45.9" "6.46" "11.52" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05030" "6760" "ENSG00000141380" "SS18" "B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6" "" "" "0" "0" "1.242" "1.138" "1.062" "0.988" "1.110" "0.990" "1.048" "1.032" "1.117" "206.6" "256.6" "235.1" "219.5" "204.3" "229.4" "204.5" "216.5" "213.2" "230.8" "" "" "" "" "" "" "" "" "" "" "166.0" "185.1" "186.7" "147.1" "141.3" "172.1" "143.2" "158.1" "213.2" "187.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8051417909882487765" "False" "High" "IsMasterProtein" "Q14562" "ATP-dependent RNA helicase DHX8 OS=Homo sapiens OX=9606 GN=DHX8 PE=1 SV=1" "0.000" "False" "6.011" "2" "3" "3" "2" "1220" "139.2" "8.32" "6.47" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf00575, Pf04408, Pf07717, Pf21010" "1659" "ENSG00000067596" "DHX8" "hsa:1659; Q14562" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.326" "1.231" "1.109" "1.113" "1.472" "0.950" "1.246" "1.321" "1.217" "13.1" "17.4" "16.1" "14.5" "14.6" "19.3" "12.4" "16.3" "17.3" "15.9" "" "" "" "" "" "" "" "" "" "" "10.5" "12.5" "12.8" "9.7" "10.1" "14.5" "8.7" "11.9" "17.3" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4861296984398641120" "False" "High" "IsMasterProtein" "P34910" "Protein EVI2B OS=Homo sapiens OX=9606 GN=EVI2B PE=1 SV=2" "0.000" "False" "6.010" "2" "1" "1" "1" "448" "48.6" "4.83" "2.28" "1" "other biological processes" "plasma membrane;other membranes" "" "" "2124" "ENSG00000185862; ENSG00000291721" "EVI2B" "B7Z4A7; hsa:2124; P34910" "" "NF1 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5030873736405490960" "False" "High" "IsMasterProtein" "Q92686" "Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1" "0.000" "False" "6.002" "18" "1" "1" "1" "78" "7.6" "7.87" "4.41" "1" "developmental processes;signal transduction" "cytosol" "other molecular function" "Pf00612" "4900" "ENSG00000154146" "NRGN" "hsa:4900; Q92686" "Long-term potentiation" "" "1" "0" "1.100" "1.056" "1.126" "0.879" "1.176" "0.964" "1.224" "1.225" "1.166" "81.2" "89.4" "85.7" "91.5" "71.4" "95.5" "78.3" "99.4" "99.5" "94.7" "" "" "" "" "" "" "" "" "" "" "65.2" "64.5" "68.1" "61.3" "49.4" "71.7" "54.8" "72.6" "99.5" "77.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2190048182398586679" "False" "High" "IsMasterProtein" "Q9NRX5" "Serine incorporator 1 OS=Homo sapiens OX=9606 GN=SERINC1 PE=1 SV=1" "0.000" "False" "5.978" "4" "2" "3" "2" "453" "50.5" "5.85" "5.59" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf03348" "57515" "ENSG00000111897" "SERINC1" "B3KY69; E1P565; hsa:57515; O75655; Q7Z2F5; Q8TAG1; Q9NRX5; Q9NTH8; Q9ULG7" "Serine biosynthesis" "Sphingolipid pathway" "2" "0" "1.123" "1.068" "1.156" "1.219" "1.379" "1.531" "1.245" "1.073" "1.250" "77.8" "87.3" "83.1" "90.0" "94.8" "107.3" "119.1" "96.8" "83.5" "97.2" "" "" "" "" "" "" "" "" "" "" "62.5" "63.0" "66.0" "60.3" "65.6" "80.5" "83.4" "70.7" "83.5" "79.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747450166338589829" "False" "High" "IsMasterProtein" "Q8IUE6" "Histone H2A type 2-B OS=Homo sapiens OX=9606 GN=H2AC21 PE=1 SV=3" "0.000" "False" "5.969" "18" "3" "7" "1" "130" "14.0" "10.89" "16.59" "3" "" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "317772" "ENSG00000184270" "H2AC21" "hsa:317772; Q8IUE6" "HATs acetylate histones; HCMV Late Events; UCH proteinases; Ub-specific processing proteases; HCMV Early Events; HDACs deacetylate histones; Metalloprotease DUBs; RMTs methylate histone arginines" "" "8" "0" "1.129" "1.149" "1.188" "1.291" "1.181" "1.096" "1.040" "1.051" "1.066" "54.8" "61.8" "62.9" "65.0" "70.7" "64.7" "60.0" "57.0" "57.6" "58.4" "" "" "" "" "" "" "" "" "" "" "44.0" "44.6" "50.0" "43.6" "48.9" "48.5" "42.0" "41.6" "57.6" "47.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5303148066491918597" "False" "High" "IsMasterProtein" "Q6PCD5" "E3 ubiquitin-protein ligase RFWD3 OS=Homo sapiens OX=9606 GN=RFWD3 PE=1 SV=3" "0.000" "False" "5.967" "2" "1" "1" "1" "774" "85.0" "6.46" "4.29" "1" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13639" "55159" "ENSG00000168411" "RFWD3" "A8K585; B2RE35; D3DUJ8; Q5XKR3; Q6PCD5; Q9H9Q3; Q9NVT4" "" "" "0" "0" "1.004" "1.456" "1.291" "1.011" "0.913" "1.434" "1.172" "1.186" "1.152" "20.1" "20.2" "29.3" "26.0" "20.3" "18.4" "28.8" "23.6" "23.8" "23.2" "" "" "" "" "" "" "" "" "" "" "16.2" "14.6" "23.3" "17.4" "14.1" "13.8" "20.2" "17.2" "23.8" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1896237481092242514" "False" "High" "IsMasterProtein" "Q8NFZ0" "F-box DNA helicase 1 OS=Homo sapiens OX=9606 GN=FBH1 PE=1 SV=2" "0.000" "False" "5.952" "2" "2" "2" "2" "1043" "117.6" "8.25" "5.25" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00580, Pf12937, Pf13361" "84893" "ENSG00000134452" "FBH1" "hsa:84893; Q5JVB0; Q5JVB1; Q7Z4Q6; Q7Z4R0; Q8N1P5; Q8N586; Q8NFZ0; Q96E82; Q96K67; Q96SW7; Q9UFB2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3783621162172782203" "False" "High" "IsMasterProtein" "P61225" "Ras-related protein Rap-2b OS=Homo sapiens OX=9606 GN=RAP2B PE=1 SV=1" "0.000" "False" "5.951" "7" "1" "1" "1" "183" "20.5" "4.81" "3.49" "1" "cell adhesion;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5912" "ENSG00000181467" "RAP2B" "hsa:5912; P17964; P61225; Q96EG5; Q9CXG0" "Neutrophil degranulation" "" "1" "0" "0.944" "0.773" "1.047" "0.961" "1.023" "1.362" "0.862" "1.002" "1.097" "58.9" "55.6" "45.5" "61.6" "56.5" "60.2" "80.1" "50.8" "59.0" "64.6" "" "" "" "" "" "" "" "" "" "" "47.3" "40.1" "36.1" "41.3" "39.1" "45.2" "56.1" "37.1" "59.0" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142144855289123481" "False" "High" "IsMasterProtein" "Q96HC4" "PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5 PE=1 SV=5" "0.000" "False" "5.939" "3" "2" "2" "2" "596" "63.9" "8.21" "4.88" "2" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "10611" "ENSG00000163110" "PDLIM5" "A8K6F9; D6RB78; E9PBF5; hsa:10611; O60705; Q56VN4; Q5UW38; Q8WVK0; Q96HC4" "Neurexins and neuroligins" "Extracellular vesicles in the crosstalk of cardiac cells" "2" "0" "1.029" "1.007" "1.055" "1.054" "0.846" "0.855" "0.916" "1.217" "1.051" "75.0" "77.2" "75.6" "79.1" "79.0" "63.5" "64.2" "68.7" "91.3" "78.9" "" "" "" "" "" "" "" "" "" "" "60.3" "55.7" "60.0" "53.0" "54.7" "47.6" "44.9" "50.2" "91.3" "64.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256207077144686062" "False" "High" "IsMasterProtein" "Q9UK61" "Protein TASOR OS=Homo sapiens OX=9606 GN=TASOR PE=1 SV=3" "0.000" "False" "5.939" "1" "2" "2" "2" "1670" "188.9" "5.80" "6.49" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12509" "23272" "ENSG00000163946" "TASOR" "A1L3A4; B5ME28; hsa:23272; Q9H2F7; Q9UK61; Q9UPP7" "" "" "0" "0" "1.050" "1.237" "1.027" "1.244" "1.171" "0.918" "1.015" "1.066" "1.209" "42.9" "45.0" "53.0" "44.0" "53.3" "50.2" "39.4" "43.5" "45.7" "51.8" "" "" "" "" "" "" "" "" "" "" "34.4" "32.5" "42.1" "29.5" "36.9" "37.7" "27.6" "31.8" "45.7" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3055099900900343627" "False" "High" "IsMasterProtein" "Q9P0M9" "Large ribosomal subunit protein bL27m OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1" "0.000" "False" "5.923" "15" "2" "2" "2" "148" "16.1" "10.42" "7.85" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01016" "51264" "ENSG00000108826" "MRPL27" "B2RE14; hsa:51264; Q9P0M9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.992" "0.962" "0.983" "0.962" "0.913" "1.021" "0.972" "0.978" "1.082" "215.6" "214.0" "207.5" "211.9" "207.3" "196.9" "220.1" "209.5" "210.8" "233.3" "" "" "" "" "" "" "" "" "" "" "173.2" "154.4" "164.9" "142.0" "143.4" "147.7" "154.1" "153.0" "210.8" "189.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3216869458966544119" "False" "High" "IsMasterProtein" "Q12983" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 OS=Homo sapiens OX=9606 GN=BNIP3 PE=1 SV=4" "0.000" "False" "5.916" "6" "1" "1" "1" "194" "21.5" "6.80" "2.91" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06553" "664" "ENSG00000176171" "BNIP3" "hsa:664; O14620; Q12983; Q96GP0" "" "Photodynamic therapy-induced HIF-1 survival signaling" "1" "0" "1.207" "1.105" "1.608" "1.680" "1.557" "1.158" "1.168" "1.293" "1.466" "17.5" "21.1" "19.3" "28.1" "29.3" "27.2" "20.2" "20.4" "22.6" "25.6" "" "" "" "" "" "" "" "" "" "" "14.0" "15.2" "15.3" "18.8" "20.3" "20.4" "14.2" "14.9" "22.6" "20.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6507814139192882220" "False" "High" "IsMasterProtein" "Q9H6K1" "Protein ILRUN OS=Homo sapiens OX=9606 GN=ILRUN PE=1 SV=2" "0.000" "False" "5.904" "6" "2" "2" "2" "298" "32.9" "4.58" "5.38" "2" "other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf14555, Pf16158" "64771" "ENSG00000196821" "ILRUN" "B2R8K7; hsa:64771; Q5VV77; Q96MG5; Q9BUR9; Q9H6K1" "" "" "0" "0" "0.894" "0.905" "0.963" "0.994" "1.058" "1.154" "1.127" "1.171" "1.080" "132.7" "118.7" "120.1" "127.8" "131.9" "140.4" "153.2" "149.6" "155.4" "143.3" "" "" "" "" "" "" "" "" "" "" "106.6" "85.6" "95.4" "85.6" "91.2" "105.3" "107.3" "109.3" "155.4" "116.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6289756953830423632" "False" "High" "IsMasterProtein" "Q8WV99" "AN1-type zinc finger protein 2B OS=Homo sapiens OX=9606 GN=ZFAND2B PE=1 SV=1" "0.000" "False" "5.903" "7" "1" "1" "1" "257" "28.0" "6.92" "4.81" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01428, Pf02809" "130617" "ENSG00000158552" "ZFAND2B" "hsa:130617; Q8NB98; Q8WV99" "" "" "0" "0" "0.922" "0.736" "0.897" "1.009" "0.930" "1.371" "1.073" "0.869" "0.909" "51.7" "47.7" "38.1" "46.4" "52.2" "48.1" "70.9" "55.5" "44.9" "47.0" "" "" "" "" "" "" "" "" "" "" "41.5" "34.4" "30.2" "31.1" "36.1" "36.1" "49.7" "40.5" "44.9" "38.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7996509007212382339" "False" "High" "IsMasterProtein" "B2RTY4" "Unconventional myosin-IXa OS=Homo sapiens OX=9606 GN=MYO9A PE=1 SV=2" "0.000" "False" "5.897" "1" "1" "2" "1" "2548" "292.5" "8.88" "5.95" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00130, Pf00612, Pf00620, Pf00788" "4649" "ENSG00000066933" "MYO9A" "B0I1T5; B2RTY4; C9IYB3; C9JA86; hsa:4649; Q14787; Q3YLD7; Q3YLD8; Q6P986; Q9H8T5; Q9NTG2; Q9NUY2; Q9UEP3; Q9UNJ2" "RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3952694843308391532" "False" "High" "IsMasterProtein" "O00257" "E3 SUMO-protein ligase CBX4 OS=Homo sapiens OX=9606 GN=CBX4 PE=1 SV=3" "0.000" "False" "5.888" "3" "2" "2" "2" "560" "61.3" "9.36" "5.85" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00385, Pf17218" "8535" "ENSG00000141582" "CBX4" "B1PJR7; hsa:8535; O00257; Q6TPI8; Q96C04" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription" "" "8" "0" "0.953" "1.029" "1.520" "1.027" "1.167" "1.680" "1.609" "1.335" "1.077" "14.3" "13.6" "14.7" "21.7" "14.7" "16.7" "24.0" "23.0" "19.1" "15.4" "" "" "" "" "" "" "" "" "" "" "11.5" "9.8" "11.7" "14.5" "10.1" "12.5" "16.8" "16.8" "19.1" "12.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "96752444028096472" "False" "High" "IsMasterProtein" "Q8WWC4" "m-AAA protease-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MAIP1 PE=1 SV=1" "0.000" "False" "5.887" "3" "1" "1" "1" "291" "32.5" "9.17" "3.35" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "translation activity" "" "79568" "ENSG00000162972" "MAIP1" "hsa:79568; Q658V9; Q8WWC4; Q9H671" "Processing of SMDT1" "" "1" "0" "1.193" "1.059" "1.126" "1.115" "1.134" "0.986" "1.151" "1.190" "1.206" "73.0" "87.2" "77.4" "82.2" "81.5" "82.9" "72.0" "84.0" "87.0" "88.1" "" "" "" "" "" "" "" "" "" "" "58.7" "62.9" "61.5" "55.1" "56.3" "62.2" "50.4" "61.4" "87.0" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6098713629868852920" "False" "High" "IsMasterProtein" "Q12772" "Sterol regulatory element-binding protein 2 OS=Homo sapiens OX=9606 GN=SREBF2 PE=1 SV=2" "0.000" "False" "5.886" "1" "1" "1" "1" "1141" "123.6" "8.40" "3.73" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6721" "ENSG00000198911" "SREBF2" "hsa:6721; Q05BD5; Q12772; Q6GTH7; Q86V36; Q9UH04" "Activation of gene expression by SREBF (SREBP); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Cholesterol biosynthesis; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Angiopoietin-like protein 8 regulatory pathway; 22q11.2 copy number variation syndrome; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways" "11" "0" "0.834" "0.671" "0.909" "0.861" "0.805" "0.797" "0.992" "0.883" "0.876" "71.2" "59.3" "47.7" "64.7" "61.3" "57.3" "56.7" "70.6" "62.8" "62.3" "" "" "" "" "" "" "" "" "" "" "57.2" "42.8" "37.9" "43.4" "42.4" "43.0" "39.7" "51.6" "62.8" "50.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1345191434985933779" "False" "High" "IsMasterProtein" "Q9UF56" "F-box/LRR-repeat protein 17 OS=Homo sapiens OX=9606 GN=FBXL17 PE=1 SV=3" "0.000" "False" "5.875" "3" "2" "2" "2" "701" "75.6" "8.07" "2.62" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12937, Pf13516" "64839" "ENSG00000145743" "FBXL17" "A1A4E3; hsa:64839; Q9UF56" "Regulation of BACH1 activity" "Hedgehog signaling pathway" "2" "0" "0.928" "0.761" "0.998" "1.137" "0.853" "1.049" "0.653" "0.969" "0.975" "34.0" "31.5" "25.8" "33.9" "38.6" "29.0" "35.6" "22.2" "32.9" "33.1" "" "" "" "" "" "" "" "" "" "" "27.3" "22.7" "20.5" "22.7" "26.7" "21.7" "24.9" "16.2" "32.9" "26.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2844619604751802100" "False" "High" "IsMasterProtein" "O00124" "UBX domain-containing protein 8 OS=Homo sapiens OX=9606 GN=UBXN8 PE=1 SV=2" "0.000" "False" "5.873" "8" "1" "1" "1" "270" "30.5" "7.78" "4.24" "1" "other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789" "7993" "ENSG00000104691" "UBXN8" "hsa:7993; O00124; Q7Z6F2" "" "" "0" "0" "1.251" "1.066" "1.095" "1.364" "1.189" "1.170" "1.352" "1.384" "0.927" "21.0" "26.3" "22.4" "23.0" "28.7" "25.0" "24.6" "28.4" "29.1" "19.5" "" "" "" "" "" "" "" "" "" "" "16.9" "19.0" "17.8" "15.4" "19.8" "18.8" "17.2" "20.8" "29.1" "15.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1924362681764607279" "False" "High" "IsMasterProtein" "Q8TBF4" "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=ZCRB1 PE=1 SV=2" "0.000" "False" "5.867" "9" "1" "1" "1" "217" "24.6" "8.53" "2.31" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00098" "85437" "ENSG00000139168" "ZCRB1" "hsa:85437; Q6PJX0; Q8TBF4; Q96TA6" "mRNA Splicing - Minor Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3097674846330682720" "False" "High" "IsMasterProtein" "O15037" "Protein KHNYN OS=Homo sapiens OX=9606 GN=KHNYN PE=1 SV=3" "0.000" "False" "5.840" "3" "3" "4" "3" "678" "74.5" "7.02" "7.98" "3" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11977" "23351" "ENSG00000100441" "KHNYN" "hsa:23351; O15037; Q86TZ6; Q8IUQ2; Q96BA9" "" "" "0" "0" "1.221" "1.206" "1.048" "1.008" "1.152" "1.027" "1.050" "1.182" "1.079" "194.6" "237.6" "234.7" "203.9" "196.2" "224.3" "199.9" "204.4" "229.9" "209.9" "" "" "" "" "" "" "" "" "" "" "156.3" "171.4" "186.5" "136.6" "135.7" "168.3" "140.0" "149.3" "229.9" "170.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7322827353079219364" "False" "High" "IsMasterProtein" "Q68DH5" "G-protein coupled receptor-associated protein LMBRD2 OS=Homo sapiens OX=9606 GN=LMBRD2 PE=1 SV=1" "0.000" "False" "5.836" "2" "1" "1" "1" "695" "81.1" "7.50" "2.94" "1" "signal transduction" "plasma membrane;other membranes" "" "Pf04791" "92255" "ENSG00000164187" "LMBRD2" "B3KRB6; hsa:92255; Q68DH5; Q9NTC7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292330841191308535" "False" "High" "IsMasterProtein" "O75420" "GRB10-interacting GYF protein 1 OS=Homo sapiens OX=9606 GN=GIGYF1 PE=1 SV=2" "0.000" "False" "5.835" "2" "2" "2" "2" "1035" "114.5" "5.39" "5.50" "2" "signal transduction" "cytosol;other cell component" "" "Pf02213" "" "ENSG00000146830" "GIGYF1" "O75420; Q6Y7W7; Q8WZ38" "" "" "0" "0" "1.082" "1.105" "1.311" "1.233" "1.063" "1.201" "1.149" "1.034" "1.309" "155.8" "168.6" "172.3" "204.3" "192.1" "165.7" "187.2" "179.1" "161.2" "204.0" "" "" "" "" "" "" "" "" "" "" "125.2" "121.7" "136.8" "136.9" "132.9" "124.3" "131.1" "130.8" "161.2" "165.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4042052557542696256" "False" "High" "IsMasterProtein" "Q8TAP8" "Protein phosphatase 1 regulatory subunit 35 OS=Homo sapiens OX=9606 GN=PPP1R35 PE=1 SV=1" "0.000" "False" "5.829" "9" "1" "1" "1" "253" "27.9" "8.68" "4.21" "1" "developmental processes;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf15503" "221908" "ENSG00000160813" "PPP1R35" "A4D2C5; hsa:221908; Q8TAP8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7379304699154124017" "False" "High" "IsMasterProtein" "Q7Z7C8" "Transcription initiation factor TFIID subunit 8 OS=Homo sapiens OX=9606 GN=TAF8 PE=1 SV=1" "0.000" "False" "5.808" "3" "1" "1" "1" "310" "34.2" "6.46" "3.72" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07524, Pf10406" "129685" "ENSG00000137413" "TAF8" "hsa:129685; Q5T0K1; Q7Z7C8; Q8N4R9; Q96M52" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.101" "1.054" "1.021" "1.110" "1.084" "0.941" "1.003" "1.063" "1.081" "220.0" "242.3" "231.9" "224.5" "244.2" "238.4" "206.9" "220.7" "233.8" "237.8" "" "" "" "" "" "" "" "" "" "" "176.7" "174.8" "184.2" "150.4" "168.9" "178.9" "144.9" "161.1" "233.8" "193.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8030741050122894286" "False" "High" "IsMasterProtein" "Q9NRH2" "SNF-related serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SNRK PE=1 SV=2" "0.000" "False" "5.800" "4" "1" "1" "1" "765" "84.2" "7.06" "2.98" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "54861" "ENSG00000163788" "SNRK" "B2RAV6; hsa:54861; Q14706; Q68D15; Q6IQ46; Q9NRH2; Q9NXI7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "Not Found" "High" "High" "Not Found" "1" "" "-957867492455840150" "False" "High" "IsMasterProtein" "Q9NR82" "Potassium voltage-gated channel subfamily KQT member 5 OS=Homo sapiens OX=9606 GN=KCNQ5 PE=1 SV=3" "0.000" "False" "5.789" "1" "1" "1" "1" "932" "102.1" "9.48" "4.06" "1" "transport" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00520, Pf03520" "56479" "ENSG00000185760" "KCNQ5" "A6NKT6; A6PVT6; A8MSQ5; B4DS33; B5MC83; B7ZL37; F5GZV0; hsa:56479; Q17RE1; Q5VVP3; Q86W40; Q9NR82; Q9NRN0; Q9NYA6" "Voltage gated Potassium channels" "" "1" "0" "1.125" "1.137" "1.272" "1.204" "1.056" "1.121" "1.186" "1.257" "1.193" "183.5" "206.4" "208.6" "233.3" "221.0" "193.7" "205.6" "217.6" "230.7" "219.0" "" "" "" "" "" "" "" "" "" "" "147.4" "148.9" "165.7" "156.3" "152.8" "145.3" "144.0" "158.9" "230.7" "178.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7030839673765711891" "False" "High" "IsMasterProtein" "Q9HC44" "Vasculin-like protein 1 OS=Homo sapiens OX=9606 GN=GPBP1L1 PE=1 SV=1" "0.000" "False" "5.786" "4" "1" "1" "1" "474" "52.3" "6.84" "4.45" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf15337" "60313" "ENSG00000159592" "GPBP1L1" "D3DQ10; hsa:60313; Q9H751; Q9HC44" "" "" "0" "0" "1.140" "1.158" "1.304" "1.231" "1.045" "1.146" "1.067" "1.108" "1.163" "82.7" "94.2" "95.7" "107.8" "101.8" "86.4" "94.8" "88.2" "91.6" "96.2" "" "" "" "" "" "" "" "" "" "" "66.4" "68.0" "76.0" "72.3" "70.4" "64.8" "66.4" "64.4" "91.6" "78.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4316199333645663287" "False" "High" "IsMasterProtein" "Q9NPG3" "Ubinuclein-1 OS=Homo sapiens OX=9606 GN=UBN1 PE=1 SV=2" "0.000" "False" "5.786" "1" "1" "1" "1" "1134" "121.4" "9.33" "3.55" "1" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf08729, Pf14075" "29855" "ENSG00000118900" "UBN1" "B7Z6D3; D3DUE8; hsa:29855; Q13079; Q9NPG3; Q9P1P7" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "15q11q13 copy number variation" "2" "0" "0.862" "0.894" "0.789" "0.857" "0.913" "0.887" "1.058" "1.125" "0.886" "87.4" "75.3" "78.1" "68.9" "74.9" "79.8" "77.5" "92.5" "98.3" "77.4" "" "" "" "" "" "" "" "" "" "" "70.2" "54.3" "62.0" "46.2" "51.8" "59.9" "54.3" "67.5" "98.3" "62.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-572232975925861742" "False" "High" "IsMasterProtein" "P46779" "Large ribosomal subunit protein eL28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "0.000" "False" "5.779" "11" "2" "2" "2" "137" "15.7" "12.02" "5.94" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1106391379852214598" "False" "High" "IsMasterProtein" "Q8NAG6" "Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKLE1 PE=1 SV=2" "0.000" "False" "5.778" "3" "2" "2" "2" "615" "66.8" "6.43" "2.65" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12796" "126549" "ENSG00000160117" "ANKLE1" "A8VU82; hsa:126549; Q8N8J8; Q8NAG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6182186368676627238" "False" "High" "IsMasterProtein" "Q13405" "Large ribosomal subunit protein mL49 OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" "0.000" "False" "5.773" "13" "2" "2" "2" "166" "19.2" "9.45" "5.96" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05046" "740" "ENSG00000149792" "MRPL49" "B2R4G6; hsa:740; Q13405" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-675276312923681114" "False" "High" "IsMasterProtein" "Q96GY0" "Zinc finger C2HC domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ZC2HC1A PE=1 SV=2" "0.000" "False" "5.769" "5" "2" "2" "2" "325" "35.1" "9.82" "3.17" "2" "" "" "other molecular function" "Pf13913" "51101" "ENSG00000104427" "ZC2HC1A" "hsa:51101; Q96GY0; Q9Y372" "" "" "0" "0" "0.965" "1.046" "0.956" "0.889" "1.065" "0.957" "0.791" "0.925" "0.982" "206.3" "199.1" "215.8" "197.1" "183.3" "219.6" "197.3" "163.2" "190.8" "202.6" "" "" "" "" "" "" "" "" "" "" "165.7" "143.7" "171.4" "132.1" "126.8" "164.8" "138.2" "119.2" "190.8" "164.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3749115953426157303" "False" "High" "IsMasterProtein" "Q6PGN9" "Proline/serine-rich coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=PSRC1 PE=1 SV=1" "0.000" "False" "5.753" "3" "1" "2" "1" "363" "38.8" "11.21" "7.29" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf15259" "84722" "ENSG00000134222" "PSRC1" "hsa:84722; Q5T2Z3; Q6PGN9; Q6ZTI8; Q71MG3; Q9BV77" "" "Aryl hydrocarbon receptor pathway" "1" "0" "1.098" "1.037" "1.060" "1.067" "0.970" "0.750" "0.747" "0.722" "0.939" "272.3" "299.2" "282.4" "288.6" "290.6" "264.1" "204.4" "203.4" "196.6" "255.7" "" "" "" "" "" "" "" "" "" "" "218.7" "215.9" "224.3" "193.3" "201.0" "198.2" "143.1" "148.5" "196.6" "208.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037316955710450301" "False" "High" "IsMasterProtein" "P38936" "Cyclin-dependent kinase inhibitor 1 OS=Homo sapiens OX=9606 GN=CDKN1A PE=1 SV=3" "0.000" "False" "5.751" "11" "1" "1" "1" "164" "18.1" "8.37" "3.26" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf02234" "1026" "ENSG00000124762" "CDKN1A" "hsa:1026; P38936; Q14010; Q6FI05; Q9BUT4" "Interleukin-4 and Interleukin-13 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Transcriptional regulation by RUNX2; Senescence-Associated Secretory Phenotype (SASP); Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Signaling by ALK fusions and activated point mutants; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Neddylation; KEAP1-NFE2L2 pathway; Constitutive Signaling by AKT1 E17K in Cancer; SCF(Skp2)-mediated degradation of p27/p21; FOXO-mediated transcription of cell cycle genes; AKT phosphorylates targets in the cytosol; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; p53-Dependent G1 DNA Damage Response; TFAP2 (AP-2) family regulates transcription of cell cycle factors; Signaling by FLT3 fusion proteins; RUNX3 regulates CDKN1A transcription; Transcriptional activation of cell cycle inhibitor p21 ; STAT5 activation downstream of FLT3 ITD mutants" "Androgen receptor signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated cancer pathway; Glioblastoma signaling pathways; Adipogenesis; Retinoblastoma gene in cancer; ATM signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Aryl hydrocarbon receptor pathway; Bladder cancer; Apoptosis-related network due to altered Notch3 in ovarian cancer; Vitamin D receptor pathway; miR-517 relationship with ARCN1 and USP1; Photodynamic therapy-induced AP-1 survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; Physico-chemical features and toxicity-associated pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Type 2 papillary renal cell carcinoma; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; FGF23 signaling in hypophosphatemic rickets and related disorders; Overlap between signal transduction pathways contributing to LMNA laminopathies; p53 transcriptional gene network; Galanin receptor pathway; Pleural mesothelioma; Orexin receptor pathway; Lipid metabolism in senescent cells; Pathophysiological roles of DUX4 in FSHD1; Omega-6-fatty acids in senescence; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent); Androgen receptor signaling pathway" "79" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2450286954911087625" "False" "High" "IsMasterProtein" "O43325" "LYR motif-containing protein 1 OS=Homo sapiens OX=9606 GN=LYRM1 PE=1 SV=1" "0.000" "False" "5.743" "20" "3" "4" "3" "122" "14.3" "9.94" "10.06" "3" "" "nucleus;other cell component" "" "Pf05347" "57149" "ENSG00000102897" "LYRM1" "B2R4M5; hsa:57149; O43325" "" "" "0" "0" "0.954" "1.127" "1.149" "1.250" "1.161" "0.947" "1.004" "0.910" "1.076" "48.2" "46.0" "54.3" "55.4" "60.2" "55.9" "45.7" "48.4" "43.9" "51.9" "" "" "" "" "" "" "" "" "" "" "38.7" "33.2" "43.1" "37.1" "41.7" "42.0" "32.0" "35.3" "43.9" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4387362286314672482" "False" "High" "IsMasterProtein" "Q14318" "Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Homo sapiens OX=9606 GN=FKBP8 PE=1 SV=2" "0.000" "False" "5.738" "6" "2" "2" "2" "412" "44.5" "4.84" "5.54" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00254" "23770" "ENSG00000105701" "FKBP8" "C8C9T5; hsa:23770; Q14318; Q53GU3; Q7Z349; Q86YK6" "Ub-specific processing proteases" "" "1" "0" "1.073" "0.803" "0.947" "1.030" "0.649" "1.143" "0.662" "1.101" "1.046" "15.7" "16.8" "12.6" "14.8" "16.1" "10.2" "17.9" "10.4" "17.2" "16.4" "" "" "" "" "" "" "" "" "" "" "12.6" "12.1" "10.0" "9.9" "11.1" "7.6" "12.5" "7.6" "17.2" "13.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677179923960499603" "False" "High" "IsMasterProtein" "Q86UD0" "Suppressor APC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SAPCD2 PE=1 SV=2" "0.000" "False" "5.730" "5" "1" "1" "1" "394" "42.6" "8.82" "3.93" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf11414" "89958" "ENSG00000186193" "SAPCD2" "hsa:89958; Q86UD0" "" "" "0" "0" "1.109" "0.854" "1.769" "1.342" "0.773" "1.434" "1.110" "0.775" "1.059" "138.5" "153.7" "118.4" "245.1" "185.9" "107.2" "198.7" "153.8" "107.4" "146.8" "" "" "" "" "" "" "" "" "" "" "111.3" "110.9" "94.0" "164.2" "128.5" "80.4" "139.1" "112.3" "107.4" "119.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8017112882834387390" "False" "High" "IsMasterProtein" "Q9Y3C0" "WASH complex subunit 3 OS=Homo sapiens OX=9606 GN=WASHC3 PE=1 SV=1" "0.000" "False" "5.729" "11" "2" "2" "2" "194" "21.2" "4.46" "5.11" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10152" "51019" "ENSG00000120860" "WASHC3" "B2RC74; hsa:51019; Q53FF0; Q6IAI4; Q96QK0; Q9Y3C0" "" "" "0" "0" "0.960" "0.972" "0.970" "0.875" "0.924" "0.794" "0.832" "0.899" "0.991" "459.6" "441.3" "446.6" "445.8" "402.4" "424.5" "365.0" "382.5" "413.1" "455.5" "" "" "" "" "" "" "" "" "" "" "369.2" "318.5" "354.7" "298.7" "278.3" "318.5" "255.5" "279.3" "413.1" "370.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140243199902963868" "False" "High" "IsMasterProtein" "Q13835" "Plakophilin-1 OS=Homo sapiens OX=9606 GN=PKP1 PE=1 SV=2" "0.000" "False" "5.726" "3" "2" "2" "2" "747" "82.8" "9.13" "4.84" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00514" "5317" "ENSG00000081277" "PKP1" "hsa:5317; O00645; Q13835; Q14CA0; Q15152" "Neutrophil degranulation; Formation of the cornified envelope; Apoptotic cleavage of cell adhesion proteins" "Epithelial to mesenchymal transition in colorectal cancer" "5" "0" "0.629" "0.153" "0.361" "0.461" "0.717" "0.795" "0.495" "0.490" "0.487" "84.6" "53.2" "12.9" "30.5" "39.0" "60.6" "67.2" "41.8" "41.5" "41.2" "" "" "" "" "" "" "" "" "" "" "67.9" "38.4" "10.3" "20.5" "27.0" "45.5" "47.0" "30.5" "41.5" "33.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2668424523932492370" "False" "High" "IsMasterProtein" "Q9BVQ7" "ATPase family gene 2 protein homolog B OS=Homo sapiens OX=9606 GN=AFG2B PE=1 SV=2" "0.000" "False" "5.724" "1" "1" "1" "1" "753" "80.7" "8.09" "3.64" "1" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9208084483559464236" "False" "High" "IsMasterProtein" "Q13423" "NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=NNT PE=1 SV=3" "0.000" "False" "5.718" "1" "1" "1" "1" "1086" "113.8" "8.09" "2.91" "1" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01262, Pf02233, Pf05222, Pf12769" "23530" "ENSG00000112992" "NNT" "hsa:23530; Q13423; Q16796; Q2TB60; Q8N3V4" "Citric acid cycle (TCA cycle)" "" "1" "0" "1.045" "0.907" "0.925" "0.716" "0.927" "1.108" "0.923" "1.020" "0.966" "60.6" "63.4" "55.0" "56.0" "43.4" "56.2" "67.1" "55.9" "61.8" "58.6" "" "" "" "" "" "" "" "" "" "" "48.7" "45.7" "43.7" "37.5" "30.0" "42.1" "47.0" "40.8" "61.8" "47.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834128013401961413" "False" "High" "IsMasterProtein" "Q4L235" "Beta-alanine-activating enzyme OS=Homo sapiens OX=9606 GN=AASDH PE=1 SV=3" "0.000" "False" "5.713" "2" "2" "2" "2" "1098" "122.5" "7.24" "6.53" "2" "other metabolic processes" "" "other molecular function" "Pf00501, Pf00550, Pf13360, Pf13570" "132949" "ENSG00000157426" "AASDH" "A5D8V3; A5PL22; hsa:132949; Q4L235; Q63HK2; Q63HR7; Q6IPP8; Q6TFZ6; Q7Z5Y3; Q96BW4; Q9P064" "" "" "0" "0" "0.819" "0.743" "0.847" "0.841" "0.980" "1.360" "1.008" "1.023" "0.994" "234.0" "191.5" "173.8" "198.3" "196.9" "229.4" "318.3" "235.9" "239.5" "232.7" "" "" "" "" "" "" "" "" "" "" "187.9" "138.2" "138.0" "132.8" "136.2" "172.1" "222.9" "172.3" "239.5" "189.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6662749909958562405" "False" "High" "IsMasterProtein" "Q99467" "CD180 antigen OS=Homo sapiens OX=9606 GN=CD180 PE=1 SV=2" "0.000" "False" "5.712" "2" "1" "1" "1" "661" "74.1" "6.43" "4.29" "1" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytoskeleton;nucleus" "" "Pf13855, Pf18831" "4064" "ENSG00000134061" "CD180" "B2R7Z7; hsa:4064; Q32MM5; Q99467" "Toll Like Receptor 4 (TLR4) Cascade" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6057822043040811216" "False" "High" "IsMasterProtein" "Q86WH2" "Ras association domain-containing protein 3 OS=Homo sapiens OX=9606 GN=RASSF3 PE=1 SV=1" "0.000" "False" "5.709" "7" "2" "2" "2" "238" "27.5" "7.44" "6.62" "2" "signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00788, Pf16517" "283349" "ENSG00000153179" "RASSF3" "hsa:283349; Q86WH1; Q86WH2" "" "Pleural mesothelioma" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7173592296681882204" "False" "High" "IsMasterProtein" "Q15651" "High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2" "0.000" "False" "5.704" "17" "2" "3" "2" "99" "10.7" "9.66" "7.90" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "9324" "ENSG00000118418" "HMGN3" "B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7" "" "" "0" "0" "0.982" "1.052" "1.027" "0.986" "1.003" "1.181" "0.869" "0.998" "0.900" "652.8" "641.0" "686.5" "670.1" "643.7" "654.7" "770.7" "567.5" "651.3" "587.7" "" "" "" "" "" "" "" "" "" "" "524.3" "462.5" "545.3" "449.0" "445.2" "491.2" "539.6" "414.5" "651.3" "477.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128550714862144269" "False" "High" "IsMasterProtein" "Q9H7E2" "Tudor domain-containing protein 3 OS=Homo sapiens OX=9606 GN=TDRD3 PE=1 SV=1" "0.000" "False" "5.702" "3" "2" "2" "2" "651" "73.1" "9.23" "3.71" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00567, Pf00627, Pf08585" "81550" "ENSG00000083544" "TDRD3" "B2MWP9; hsa:81550; Q53XA6; Q6P992; Q9H7E2" "" "" "0" "0" "1.235" "1.357" "1.481" "1.393" "1.167" "1.357" "1.368" "1.278" "1.330" "53.4" "66.0" "72.5" "79.1" "74.4" "62.4" "72.5" "73.1" "68.3" "71.1" "" "" "" "" "" "" "" "" "" "" "42.9" "47.6" "57.6" "53.0" "51.5" "46.8" "50.8" "53.4" "68.3" "57.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6582781220812182564" "False" "High" "IsMasterProtein" "Q9NX70" "Mediator of RNA polymerase II transcription subunit 29 OS=Homo sapiens OX=9606 GN=MED29 PE=1 SV=1" "0.000" "False" "5.688" "6" "1" "1" "1" "200" "21.1" "6.29" "4.93" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11568" "55588" "ENSG00000063322" "MED29" "B4DNQ6; hsa:55588; M0R2E4; Q5XX09; Q9NTF4; Q9NX70" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "1.004" "1.087" "0.970" "1.098" "1.117" "0.931" "0.978" "1.124" "1.056" "134.9" "135.5" "146.6" "130.9" "148.2" "150.7" "125.6" "132.0" "151.6" "142.4" "" "" "" "" "" "" "" "" "" "" "108.4" "97.8" "116.5" "87.7" "102.5" "113.1" "87.9" "96.4" "151.6" "115.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2197704674171232077" "False" "High" "IsMasterProtein" "Q52LR7" "Enhancer of polycomb homolog 2 OS=Homo sapiens OX=9606 GN=EPC2 PE=1 SV=2" "0.000" "False" "5.679" "2" "2" "2" "2" "807" "91.0" "8.73" "5.84" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf06752, Pf10513" "26122" "ENSG00000135999" "EPC2" "B3KWT7; D3DP89; hsa:26122; Q52LR7; Q7L9J1; Q96RR7; Q9NUT8; Q9NVR1; Q9UFM9" "" "" "0" "0" "1.105" "0.928" "0.979" "1.015" "1.105" "0.924" "0.997" "1.023" "1.038" "467.6" "516.5" "433.9" "457.7" "474.7" "516.5" "432.1" "466.0" "478.5" "485.5" "" "" "" "" "" "" "" "" "" "" "375.5" "372.7" "344.7" "306.7" "328.3" "387.5" "302.6" "340.3" "478.5" "394.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "921015601734108377" "False" "High" "IsMasterProtein" "Q6P4Q7" "Metal transporter CNNM4 OS=Homo sapiens OX=9606 GN=CNNM4 PE=1 SV=3" "0.000" "False" "5.664" "2" "1" "1" "1" "775" "86.6" "6.07" "2.82" "1" "transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00571, Pf01595" "26504" "ENSG00000158158" "CNNM4" "B7Z1U0; C7SQM3; C7SQM4; C7SQM5; hsa:26504; Q53RE5; Q6P4Q7; Q9H9G3; Q9HCI0; Q9NRN1" "" "2q11.2 copy number variation syndrome" "1" "0" "0.935" "0.931" "1.260" "0.895" "0.697" "1.235" "0.894" "0.886" "0.953" "67.0" "62.6" "62.3" "84.4" "59.9" "46.7" "82.7" "59.9" "59.3" "63.8" "" "" "" "" "" "" "" "" "" "" "53.8" "45.2" "49.5" "56.5" "41.4" "35.0" "57.9" "43.7" "59.3" "51.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8996103182095070186" "False" "High" "IsMasterProtein" "Q9UBF6" "RING-box protein 2 OS=Homo sapiens OX=9606 GN=RNF7 PE=1 SV=1" "0.000" "False" "5.661" "11" "1" "1" "1" "113" "12.7" "5.44" "3.49" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9616" "ENSG00000114125" "RNF7" "A8K1H9; A8MTB5; C9JYL3; D3DNF7; D3DNF8; hsa:9616; Q9BXN8; Q9UBF6; Q9Y5M7" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Inactivation of CSF3 (G-CSF) signaling" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Modulators of TCR signaling and T cell activation" "5" "0" "1.083" "1.024" "1.039" "1.110" "1.247" "1.238" "1.332" "1.260" "1.392" "46.2" "50.0" "47.3" "48.0" "51.3" "57.6" "57.1" "61.5" "58.2" "64.3" "" "" "" "" "" "" "" "" "" "" "37.1" "36.1" "37.5" "32.1" "35.5" "43.2" "40.0" "44.9" "58.2" "52.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7773792101669392702" "False" "High" "IsMasterProtein" "O94880" "PHD finger protein 14 OS=Homo sapiens OX=9606 GN=PHF14 PE=1 SV=3" "0.000" "False" "5.658" "1" "1" "2" "1" "948" "106.9" "5.34" "3.45" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf13831, Pf13832" "9678" "ENSG00000106443" "PHF14" "A0A0U1RRH6; A7MCZ3; B4DI82; hsa:9678; O94880" "" "" "0" "0" "0.868" "0.963" "1.051" "1.005" "1.013" "1.224" "1.133" "1.102" "1.042" "266.5" "231.2" "256.6" "280.3" "267.9" "270.1" "326.1" "301.9" "293.7" "277.8" "" "" "" "" "" "" "" "" "" "" "214.1" "166.8" "203.8" "187.8" "185.3" "202.7" "228.3" "220.5" "293.7" "225.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088997935077204775" "False" "High" "IsMasterProtein" "Q03393" "6-pyruvoyl tetrahydrobiopterin synthase OS=Homo sapiens OX=9606 GN=PTS PE=1 SV=1" "0.000" "False" "5.649" "8" "1" "2" "1" "145" "16.4" "6.68" "6.18" "1" "other metabolic processes;developmental processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01242" "5805" "ENSG00000150787" "PTS" "B0YJ87; hsa:5805; Q03393; Q8WVG8" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "" "1" "0" "1.386" "1.375" "1.282" "1.362" "1.441" "1.268" "1.266" "1.080" "1.532" "32.0" "44.4" "44.0" "41.1" "43.6" "46.1" "40.6" "40.5" "34.6" "49.1" "" "" "" "" "" "" "" "" "" "" "25.7" "32.0" "35.0" "27.5" "30.2" "34.6" "28.4" "29.6" "34.6" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2188694366700253397" "False" "High" "IsMasterProtein" "Q2TAK8" "PWWP domain-containing DNA repair factor 3A OS=Homo sapiens OX=9606 GN=PWWP3A PE=1 SV=3" "0.000" "False" "5.633" "4" "2" "2" "2" "710" "78.6" "8.54" "5.75" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus" "other molecular function" "Pf20884, Pf20886, Pf20887" "84939" "ENSG00000160953" "PWWP3A" "A1L489; B5ME02; B7ZLY8; hsa:84939; J3KQD6; Q13109; Q2TAK8; Q5XKB9; Q8N2I4; Q96A67" "" "IL-18 signaling pathway" "1" "0" "1.218" "1.165" "1.060" "1.041" "1.120" "1.018" "1.136" "1.071" "1.121" "70.4" "85.7" "82.0" "74.6" "73.3" "78.8" "71.6" "80.0" "75.4" "78.9" "" "" "" "" "" "" "" "" "" "" "56.5" "61.9" "65.1" "50.0" "50.7" "59.1" "50.2" "58.4" "75.4" "64.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7855128710481582123" "False" "High" "IsMasterProtein" "P50238" "Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3" "0.000" "False" "5.629" "21" "2" "5" "2" "77" "8.5" "8.75" "8.84" "2" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00412" "1396" "ENSG00000213145" "CRIP1" "H3BPI2; hsa:1396; P50238; Q13628; Q53XY7; Q96J34" "" "" "0" "0" "0.890" "1.082" "0.965" "1.050" "0.965" "1.061" "1.072" "1.045" "0.980" "227.3" "202.3" "246.0" "219.4" "238.7" "219.3" "241.2" "243.7" "237.5" "222.6" "" "" "" "" "" "" "" "" "" "" "182.6" "146.0" "195.4" "147.0" "165.1" "164.6" "168.8" "177.9" "237.5" "181.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2076182377996629975" "False" "High" "IsMasterProtein" "Q9H8U3" "AN1-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=ZFAND3 PE=1 SV=1" "0.000" "False" "5.621" "5" "1" "1" "1" "227" "25.2" "7.43" "3.80" "1" "" "" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "60685" "ENSG00000156639" "ZFAND3" "hsa:60685; Q5SZZ0; Q5SZZ1; Q9H8U3" "" "" "0" "0" "0.983" "0.749" "1.013" "0.800" "1.018" "0.812" "0.774" "0.903" "0.924" "105.9" "104.1" "79.3" "107.3" "84.7" "107.8" "86.0" "82.0" "95.7" "97.8" "" "" "" "" "" "" "" "" "" "" "85.0" "75.1" "63.0" "71.9" "58.6" "80.9" "60.2" "59.9" "95.7" "79.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-90342498941342912" "False" "High" "IsMasterProtein" "Q8N8R5" "Mitochondrial protein C2orf69 OS=Homo sapiens OX=9606 GN=C2orf69 PE=1 SV=1" "0.000" "False" "5.617" "4" "2" "2" "2" "385" "43.4" "8.09" "6.02" "2" "other metabolic processes" "other membranes;mitochondrion" "" "Pf10561" "205327" "ENSG00000178074" "C2orf69" "hsa:205327; Q8N8R5; Q8NE30" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5909763123883189611" "False" "High" "IsMasterProtein" "Cont_Q2YDI2" "Origin recognition complex subunit 4 OS=Bos taurus OX=9913 GN=ORC4 PE=2 SV=1" "0.000" "True" "5.610" "4" "2" "3" "2" "436" "50.3" "8.05" "8.01" "2" "DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13191, Pf14629" "102270512; 104988602; 529245" "ENSBGRG00000005070; ENSBIXG00005017338; ENSBTAG00000015291" "ORC4" "A0A4W2G4S1; A0A6B0R724; A0A6P3H454; A0A8B9WJB0; bbis:104988602; bom:102270512; bta:529245; Q2YDI2" "Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; CDC6 association with the ORC:origin complex; Orc1 removal from chromatin; Activation of the pre-replicative complex" "G1 to S cell cycle control; Cell cycle; DNA replication" "8" "0" "1.055" "0.864" "1.082" "1.249" "1.031" "0.917" "0.996" "0.899" "0.906" "98.9" "104.4" "85.5" "107.0" "123.6" "102.0" "90.8" "98.5" "89.0" "89.6" "" "" "" "" "" "" "" "" "" "" "79.5" "75.3" "67.9" "71.7" "85.5" "76.5" "63.5" "72.0" "89.0" "72.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6282194941215119925" "False" "High" "IsMasterProtein" "Q9HAW0" "Transcription factor IIIB 50 kDa subunit OS=Homo sapiens OX=9606 GN=BRF2 PE=1 SV=1" "0.000" "False" "5.609" "2" "1" "1" "1" "419" "46.5" "7.94" "3.19" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08271" "55290" "ENSG00000104221" "BRF2" "B2RD62; B4DFZ6; D3DSW6; hsa:55290; Q9H2Y3; Q9H3B3; Q9HAW0; Q9NUY6" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "" "2" "0" "1.353" "1.144" "1.291" "1.111" "1.150" "1.202" "1.246" "1.301" "1.041" "30.4" "41.2" "34.8" "39.3" "33.8" "35.0" "36.6" "37.9" "39.6" "31.7" "" "" "" "" "" "" "" "" "" "" "24.4" "29.7" "27.7" "26.3" "23.4" "26.2" "25.6" "27.7" "39.6" "25.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6907811581051477229" "False" "High" "IsMasterProtein" "Q9P2J9" "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PDP2 PE=1 SV=2" "0.000" "False" "5.600" "3" "1" "1" "1" "529" "59.9" "6.07" "2.55" "1" "" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00481" "57546" "ENSG00000172840" "PDP2" "A8K924; hsa:57546; Q9P2J9" "Regulation of pyruvate dehydrogenase (PDH) complex" "TCA cycle in senescence" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3715584417028259664" "False" "High" "IsMasterProtein" "P56381" "ATP synthase subunit epsilon, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1E PE=1 SV=2" "0.000" "False" "5.590" "43" "3" "5" "3" "51" "5.8" "9.92" "12.68" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "514" "ENSG00000124172" "ATP5F1E" "B2RDD0; E1P5H6; hsa:514; P56381; Q53XU6" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "0.948" "1.043" "0.984" "0.915" "1.060" "0.946" "0.976" "0.995" "0.950" "533.9" "506.1" "557.0" "525.2" "488.6" "566.0" "504.8" "521.2" "531.3" "507.3" "" "" "" "" "" "" "" "" "" "" "428.8" "365.2" "442.4" "351.9" "337.9" "424.7" "353.5" "380.6" "531.3" "412.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9037426309810647752" "False" "High" "IsMasterProtein" "Q9BYG5" "Partitioning defective 6 homolog beta OS=Homo sapiens OX=9606 GN=PARD6B PE=1 SV=1" "0.000" "False" "5.589" "3" "1" "1" "1" "372" "41.2" "5.58" "3.60" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf00564, Pf00595" "84612" "ENSG00000124171" "PARD6B" "A2A2A7; hsa:84612; Q9BYG5; Q9Y510" "RHOV GTPase cycle; Tight junction interactions" "Complement system in neuronal development and plasticity; 1p36 copy number variation syndrome" "4" "0" "1.191" "1.136" "1.195" "1.053" "0.970" "1.132" "1.096" "1.048" "1.036" "241.7" "287.9" "274.6" "288.8" "254.4" "234.4" "273.7" "265.0" "253.4" "250.4" "" "" "" "" "" "" "" "" "" "" "194.1" "207.7" "218.1" "193.5" "176.0" "175.9" "191.6" "193.5" "253.4" "203.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4494459322637692894" "False" "High" "IsMasterProtein" "Q5VSY0" "G kinase-anchoring protein 1 OS=Homo sapiens OX=9606 GN=GKAP1 PE=1 SV=2" "0.000" "False" "5.569" "3" "1" "1" "1" "366" "42.1" "8.82" "3.11" "1" "signal transduction;other biological processes" "ER/Golgi" "other molecular function" "" "80318" "ENSG00000165113" "GKAP1" "hsa:80318; Q5VSY0; Q96LI0; Q9BYI1; Q9BYI2; Q9H225" "" "" "0" "0" "0.900" "1.340" "1.248" "0.975" "1.157" "1.418" "1.126" "1.129" "1.005" "27.7" "24.9" "37.0" "34.5" "27.0" "32.0" "39.2" "31.1" "31.2" "27.8" "" "" "" "" "" "" "" "" "" "" "22.2" "18.0" "29.4" "23.1" "18.7" "24.0" "27.5" "22.7" "31.2" "22.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9115866675213369101" "False" "High" "IsMasterProtein" "Q99807" "5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ7 PE=1 SV=3" "0.000" "False" "5.559" "9" "2" "2" "2" "217" "24.3" "8.59" "2.54" "2" "other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf03232" "10229" "ENSG00000167186" "COQ7" "B2RDA9; hsa:10229; Q99807; Q9BTT7; Q9H0T5; Q9UEW5; Q9UNR5" "Ubiquinol biosynthesis" "" "1" "0" "0.944" "0.904" "0.991" "0.960" "1.111" "0.870" "0.829" "0.935" "0.869" "188.8" "178.2" "170.7" "187.1" "181.2" "209.8" "164.3" "156.5" "176.5" "164.0" "" "" "" "" "" "" "" "" "" "" "151.6" "128.6" "135.6" "125.4" "125.3" "157.4" "115.1" "114.3" "176.5" "133.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624164927491725104" "False" "High" "IsMasterProtein" "O75449" "Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1" "0.000" "False" "5.549" "3" "2" "2" "1" "491" "55.9" "6.90" "6.21" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "11104" "ENSG00000186625" "KATNA1" "E1P5A3; hsa:11104; O75449; Q5TFA8; Q5TFA9; Q86VN2; Q9NU52" "" "" "0" "0" "1.053" "1.162" "0.876" "0.950" "1.099" "0.878" "0.998" "1.094" "1.159" "239.5" "252.3" "278.3" "209.8" "227.5" "263.1" "210.2" "239.1" "261.9" "277.5" "" "" "" "" "" "" "" "" "" "" "192.3" "182.0" "221.1" "140.6" "157.3" "197.4" "147.2" "174.6" "261.9" "225.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2559910864719892942" "False" "High" "IsMasterProtein" "Q9NU19" "TBC1 domain family member 22B OS=Homo sapiens OX=9606 GN=TBC1D22B PE=1 SV=3" "0.000" "False" "5.547" "3" "2" "3" "1" "505" "59.0" "7.39" "9.07" "2" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "55633" "ENSG00000065491" "TBC1D22B" "A8KA28; hsa:55633; Q32MQ8; Q5VUK9; Q6P4C3; Q7Z6P7; Q9BPV6; Q9BUT5; Q9NU19; Q9NXB6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6322576459719566173" "False" "High" "IsMasterProtein" "Cont_P02754" "Beta-lactoglobulin OS=Bos taurus OX=9913 GN=LGB PE=1 SV=3" "0.000" "True" "5.546" "11" "2" "2" "2" "178" "19.9" "5.02" "6.71" "2" "" "non-structural extracellular" "other molecular function" "Pf00061" "280838" "ENSBIXG00000010604; ENSBIXG00005010722; ENSBTAG00000014678" "LGB; LOC113901792" "A0A4W2BVI6; bta:280838; P02754; Q32P89" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7218272349989461582" "False" "High" "IsMasterProtein" "Q9H211" "DNA replication factor Cdt1 OS=Homo sapiens OX=9606 GN=CDT1 PE=1 SV=3" "0.000" "False" "5.544" "2" "1" "1" "1" "546" "60.4" "9.77" "2.94" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08839, Pf16679" "81620" "ENSG00000167513" "CDT1" "hsa:81620; Q86XX9; Q96CJ5; Q96GK5; Q96H67; Q96HE6; Q9BWM0; Q9H211" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of the pre-replicative complex; G1/S-Specific Transcription" "Retinoblastoma gene in cancer; DNA replication" "7" "0" "0.930" "0.920" "0.976" "1.031" "0.848" "0.565" "0.666" "0.617" "0.902" "114.5" "106.5" "105.3" "111.8" "118.0" "97.2" "64.7" "76.2" "70.7" "103.3" "" "" "" "" "" "" "" "" "" "" "92.0" "76.8" "83.6" "74.9" "81.6" "72.9" "45.3" "55.7" "70.7" "84.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7903736519056340786" "False" "High" "IsMasterProtein" "P53985" "Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3" "0.000" "False" "5.539" "4" "2" "3" "2" "500" "53.9" "8.66" "9.36" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;other molecular function" "" "6566" "ENSG00000155380; ENSG00000281917" "SLC16A1" "hsa:6566; P53985; Q49A45; Q5T8R6; Q9NSJ9" "Basigin interactions; Pyruvate metabolism; Aspirin ADME; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome; Glucose metabolism in triple-negative breast cancer cells" "8" "0" "0.832" "0.830" "1.076" "0.960" "1.252" "2.057" "1.354" "1.543" "1.072" "236.8" "197.1" "196.6" "254.8" "227.4" "296.4" "487.1" "320.7" "365.3" "253.8" "" "" "" "" "" "" "" "" "" "" "190.2" "142.2" "156.2" "170.7" "157.3" "222.4" "341.1" "234.2" "365.3" "206.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4612354553252099721" "False" "High" "IsMasterProtein" "Q12981" "Vesicle transport protein SEC20 OS=Homo sapiens OX=9606 GN=BNIP1 PE=1 SV=3" "0.000" "False" "5.536" "5" "1" "1" "1" "228" "26.1" "8.95" "4.32" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf03908" "662" "ENSG00000113734" "BNIP1" "D3DQM3; D3DQM4; D3DQM5; D3DQM6; hsa:662; O75622; O75623; O75624; Q12981; Q6K044; Q96FG4" "COPI-dependent Golgi-to-ER retrograde traffic" "" "1" "0" "1.014" "0.935" "0.974" "0.866" "0.993" "1.020" "1.057" "0.964" "0.863" "340.9" "345.7" "318.8" "332.0" "295.4" "338.5" "347.7" "360.4" "328.5" "294.1" "" "" "" "" "" "" "" "" "" "" "273.8" "249.5" "253.3" "222.4" "204.3" "254.0" "243.5" "263.2" "328.5" "239.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1157936408086935804" "False" "High" "IsMasterProtein" "O75446" "Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1" "0.000" "False" "5.536" "7" "2" "2" "2" "220" "23.3" "9.17" "5.99" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "8819" "ENSG00000164105" "SAP30" "D3DP38; hsa:8819; O75446" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "Retinoblastoma gene in cancer; Notch signaling pathway" "5" "0" "0.997" "1.093" "0.952" "0.987" "1.137" "0.975" "1.038" "0.975" "1.028" "83.0" "82.8" "90.7" "79.0" "81.9" "94.4" "80.9" "86.2" "80.9" "85.3" "" "" "" "" "" "" "" "" "" "" "66.7" "59.7" "72.1" "52.9" "56.7" "70.8" "56.7" "62.9" "80.9" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3335218336630157461" "False" "High" "IsMasterProtein" "Q9UFN0" "Protein NipSnap homolog 3A OS=Homo sapiens OX=9606 GN=NIPSNAP3A PE=1 SV=2" "0.000" "False" "5.534" "6" "1" "2" "1" "247" "28.4" "9.16" "8.70" "1" "" "cytosol;mitochondrion" "" "Pf07978" "25934" "ENSG00000136783" "NIPSNAP3A" "A6NM55; hsa:25934; Q5VX32; Q9BRV7; Q9H843; Q9P083; Q9UFN0" "" "" "0" "0" "0.978" "0.997" "1.212" "1.008" "0.994" "1.036" "0.981" "0.844" "1.137" "102.2" "100.0" "101.8" "123.8" "103.0" "101.6" "105.9" "100.2" "86.2" "116.1" "" "" "" "" "" "" "" "" "" "" "82.1" "72.1" "80.9" "82.9" "71.2" "76.2" "74.1" "73.2" "86.2" "94.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6360176631635833399" "False" "High" "IsMasterProtein" "P25054" "Adenomatous polyposis coli protein OS=Homo sapiens OX=9606 GN=APC PE=1 SV=2" "0.000" "False" "5.532" "0" "1" "1" "1" "2843" "311.5" "7.80" "2.85" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00514, Pf05923, Pf05924, Pf05937, Pf05956, Pf05972, Pf11414, Pf16629, Pf16630, Pf16633, Pf16634, Pf16635, Pf16636, Pf16689, Pf18797" "324" "ENSG00000134982" "APC" "B7Z2B6; D3DT03; hsa:324; P25054; Q15162; Q15163; Q93042" "Deactivation of the beta-catenin transactivating complex; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Ovarian tumor domain proteases; Apoptotic cleavage of cellular proteins; APC truncation mutants are not K63 polyubiquitinated" "Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Gastric cancer network 1; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Copper homeostasis; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Regulation of sister chromatid separation at the metaphase-anaphase transition; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Cohesin complex - Cornelia de Lange syndrome; Alzheimer's disease; 2q21.1 copy number variation syndrome; HDAC6 interactions in the central nervous system; DNA damage response (only ATM dependent)" "45" "0" "1.136" "1.084" "0.788" "1.268" "1.117" "1.389" "1.417" "1.217" "1.360" "20.4" "23.1" "22.1" "16.1" "25.8" "22.8" "28.3" "28.9" "24.8" "27.7" "" "" "" "" "" "" "" "" "" "" "16.4" "16.7" "17.5" "10.8" "17.9" "17.1" "19.8" "21.1" "24.8" "22.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-234938857148189844" "False" "High" "IsMasterProtein" "Q9Y2R2" "Tyrosine-protein phosphatase non-receptor type 22 OS=Homo sapiens OX=9606 GN=PTPN22 PE=1 SV=2" "0.000" "False" "5.531" "2" "2" "2" "2" "807" "91.6" "7.59" "6.07" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26191" "ENSG00000134242" "PTPN22" "A0N0K6; B1ALC8; D4NZ71; E9PLD8; E9PPI1; hsa:26191; O95063; O95064; Q6IPX8; Q8WVM1; Q9Y2R2" "Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse" "Genes associated with the development of rheumatoid arthritis" "3" "0" "1.056" "0.993" "0.950" "1.078" "1.073" "1.115" "1.183" "1.064" "1.130" "156.4" "165.2" "155.4" "148.6" "168.6" "167.9" "174.5" "185.1" "166.4" "176.8" "" "" "" "" "" "" "" "" "" "" "125.6" "119.2" "123.4" "99.5" "116.6" "126.0" "122.1" "135.2" "166.4" "143.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4573891914704923062" "False" "High" "IsMasterProtein" "Q9BTE1" "Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1" "0.000" "False" "5.527" "10" "2" "2" "2" "182" "20.1" "8.02" "5.11" "2" "developmental processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf21711" "84516" "ENSG00000166847" "DCTN5" "A8K9X8; H3BN51; H3BQA4; hsa:84516; Q9BTE1" "COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic" "Vasopressin-regulated water reabsorption" "5" "0" "0.894" "0.938" "0.957" "0.940" "0.905" "0.881" "0.829" "0.897" "0.898" "337.7" "302.1" "316.8" "323.3" "317.4" "305.6" "297.4" "280.1" "303.1" "303.2" "" "" "" "" "" "" "" "" "" "" "271.3" "218.0" "251.6" "216.6" "219.5" "229.3" "208.2" "204.6" "303.1" "246.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6599360429670756188" "False" "High" "IsMasterProtein" "Q92902" "BLOC-3 complex member HPS1 OS=Homo sapiens OX=9606 GN=HPS1 PE=1 SV=2" "0.000" "False" "5.509" "3" "2" "2" "2" "700" "79.2" "5.91" "5.72" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf19036, Pf19037, Pf19038" "3257" "ENSG00000107521" "HPS1" "A8MRT2; O15402; O15502; Q5TAA3; Q8WXE5; Q92902" "RAB GEFs exchange GTP for GDP on RABs" "IL-18 signaling pathway" "2" "0" "0.829" "0.781" "1.100" "1.038" "0.898" "1.153" "0.948" "0.800" "0.929" "203.3" "168.6" "158.8" "223.6" "211.1" "182.6" "234.4" "192.6" "162.7" "188.8" "" "" "" "" "" "" "" "" "" "" "163.3" "121.7" "126.1" "149.8" "146.0" "137.0" "164.1" "140.7" "162.7" "153.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946997143680763818" "False" "High" "IsMasterProtein" "Q8TDG4" "Helicase POLQ-like OS=Homo sapiens OX=9606 GN=HELQ PE=1 SV=2" "0.000" "False" "5.505" "1" "1" "1" "1" "1101" "124.1" "6.58" "3.88" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf20470, Pf21099" "113510" "ENSG00000163312" "HELQ" "hsa:113510; Q05DF9; Q502W9; Q659B8; Q6ZQX4; Q6ZTS4; Q8TDG4; Q96EX7" "" "Primary ovarian insufficiency" "1" "0" "1.631" "1.162" "1.679" "1.202" "1.136" "1.280" "1.556" "1.414" "1.479" "24.5" "39.9" "28.4" "41.1" "29.4" "27.8" "31.3" "38.1" "34.6" "36.2" "" "" "" "" "" "" "" "" "" "" "19.7" "28.8" "22.6" "27.5" "20.3" "20.9" "21.9" "27.8" "34.6" "29.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7107318601171383488" "False" "High" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "0.000" "False" "5.490" "13" "3" "4" "3" "167" "19.4" "7.40" "9.41" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "1.078" "0.924" "0.948" "0.988" "1.158" "0.996" "0.969" "1.038" "1.064" "111.9" "120.7" "103.4" "106.1" "110.6" "129.6" "111.5" "108.4" "116.2" "119.1" "" "" "" "" "" "" "" "" "" "" "89.9" "87.1" "82.2" "71.1" "76.5" "97.2" "78.0" "79.2" "116.2" "96.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054599493317546199" "False" "High" "IsMasterProtein" "Q8TCC3" "Large ribosomal subunit protein uL30m OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1" "0.000" "False" "5.444" "11" "2" "2" "2" "161" "18.5" "9.99" "5.84" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00327" "51263" "ENSG00000185414" "MRPL30" "A6NIC6; D3DVI0; D3DVI3; hsa:51263; Q0D2Q7; Q6ZTP4; Q8TCC3; Q96Q69; Q9P0N0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.973" "1.039" "0.945" "1.124" "1.044" "1.053" "1.190" "1.089" "1.130" "151.3" "147.2" "157.2" "143.0" "170.1" "157.9" "159.4" "180.1" "164.7" "170.9" "" "" "" "" "" "" "" "" "" "" "121.5" "106.2" "124.9" "95.8" "117.6" "118.5" "111.6" "131.5" "164.7" "139.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827521234037792457" "False" "High" "IsMasterProtein" "Q9NUS5" "AP-5 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP5S1 PE=1 SV=1" "0.000" "False" "5.430" "12" "3" "3" "2" "200" "22.5" "6.87" "7.12" "3" "DNA metabolism;stress response;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf15001" "55317" "ENSG00000125843" "AP5S1" "B3KSD0; D3DVY7; hsa:55317; Q9NUS5" "" "" "0" "0" "0.971" "1.053" "1.000" "1.024" "0.946" "1.004" "0.964" "0.967" "1.069" "157.6" "153.0" "166.0" "157.6" "161.3" "149.1" "158.3" "152.0" "152.4" "168.5" "" "" "" "" "" "" "" "" "" "" "126.6" "110.4" "131.8" "105.6" "111.6" "111.9" "110.8" "111.0" "152.4" "137.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4624493070796375817" "False" "High" "IsMasterProtein" "Q7Z7H8" "Large ribosomal subunit protein uL10m OS=Homo sapiens OX=9606 GN=MRPL10 PE=1 SV=3" "0.000" "False" "5.428" "6" "2" "2" "2" "261" "29.3" "9.58" "4.37" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00466" "124995" "ENSG00000159111" "MRPL10" "A6NGJ4; hsa:124995; Q7Z7H8; Q96B80; Q96Q55" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.078" "0.912" "1.087" "0.996" "0.843" "0.819" "0.962" "0.879" "1.034" "226.1" "243.8" "206.2" "245.7" "225.2" "190.6" "185.2" "217.5" "198.8" "233.7" "" "" "" "" "" "" "" "" "" "" "181.6" "175.9" "163.8" "164.6" "155.8" "143.0" "129.7" "158.9" "198.8" "190.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1625803312962444269" "False" "High" "IsMasterProtein" "Q15269" "Periodic tryptophan protein 2 homolog OS=Homo sapiens OX=9606 GN=PWP2 PE=1 SV=2" "0.000" "False" "5.426" "1" "1" "1" "1" "919" "102.4" "6.15" "3.21" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf04003" "5822" "ENSG00000241945" "PWP2" "B2RAG8; hsa:5822; Q15269; Q96A77" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7987023107357595156" "False" "High" "IsMasterProtein" "Q9Y576" "Ankyrin repeat and SOCS box protein 1 OS=Homo sapiens OX=9606 GN=ASB1 PE=1 SV=1" "0.000" "False" "5.421" "4" "1" "1" "1" "335" "37.0" "8.21" "4.10" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00023, Pf07525, Pf12796" "51665" "ENSG00000065802" "ASB1" "A6NL50; hsa:51665; Q4ZG29; Q9ULS4; Q9Y576" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2q37 copy number variation syndrome" "3" "0" "1.049" "0.620" "0.743" "0.680" "0.838" "0.942" "0.795" "0.954" "0.630" "28.3" "29.6" "17.5" "21.0" "19.2" "23.7" "26.6" "22.4" "26.9" "17.8" "" "" "" "" "" "" "" "" "" "" "22.7" "21.4" "13.9" "14.1" "13.3" "17.8" "18.6" "16.4" "26.9" "14.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9052184028571704461" "False" "High" "IsMasterProtein" "O75865" "Trafficking protein particle complex subunit 6A OS=Homo sapiens OX=9606 GN=TRAPPC6A PE=1 SV=2" "0.000" "False" "5.419" "17" "3" "3" "3" "159" "17.6" "5.26" "7.29" "3" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf04051" "79090" "ENSG00000007255" "TRAPPC6A" "hsa:79090; K7ERB1; K7ERQ4; O75865; Q9BQ45; Q9P092" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.014" "0.925" "1.153" "1.047" "0.978" "1.016" "0.979" "1.033" "1.009" "261.4" "265.0" "241.8" "301.4" "273.8" "255.5" "265.5" "255.8" "269.9" "263.7" "" "" "" "" "" "" "" "" "" "" "209.9" "191.2" "192.1" "202.0" "189.3" "191.7" "185.9" "186.8" "269.9" "214.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386390429922052902" "False" "High" "IsMasterProtein" "Q8TBF2" "Prostamide/prostaglandin F synthase OS=Homo sapiens OX=9606 GN=PRXL2B PE=1 SV=1" "0.000" "False" "5.409" "6" "1" "1" "1" "198" "21.2" "6.67" "3.79" "1" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13911" "127281" "ENSG00000157870" "PRXL2B" "A8K793; B3KPY3; B4DQR9; B4E0S5; B7ZAC8; B9DI90; B9DI92; J3KQD0; Q8N2H0; Q8TBF2" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Eicosanoid metabolism via cyclooxygenases (COX); Omega-6-fatty acids in senescence" "3" "0" "0.821" "1.081" "1.067" "1.047" "0.977" "0.962" "1.037" "1.008" "0.996" "110.5" "90.7" "119.4" "117.9" "115.7" "108.0" "106.2" "114.6" "111.4" "110.0" "" "" "" "" "" "" "" "" "" "" "88.7" "65.5" "94.8" "79.0" "80.0" "81.0" "74.4" "83.7" "111.4" "89.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595761277015332679" "False" "High" "IsMasterProtein" "Q5TA50" "Ceramide-1-phosphate transfer protein OS=Homo sapiens OX=9606 GN=CPTP PE=1 SV=1" "0.000" "False" "5.408" "11" "2" "2" "2" "214" "24.4" "7.21" "5.06" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf08718" "80772" "ENSG00000224051" "CPTP" "hsa:80772; Q4G0E6; Q5TA50; Q7L5A4" "Glycosphingolipid transport" "1p36 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4393655725346314780" "False" "High" "IsMasterProtein" "Q8NHY2" "E3 ubiquitin-protein ligase COP1 OS=Homo sapiens OX=9606 GN=COP1 PE=1 SV=1" "0.000" "False" "5.405" "1" "1" "1" "1" "731" "80.4" "6.84" "3.76" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400, Pf13923" "64326" "ENSG00000143207" "COP1" "E9PKI0; Q504W6; Q6H103; Q8NHY2; Q9H6L7; X5D9B4" "Neddylation; Autodegradation of the E3 ubiquitin ligase COP1" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7148094604996287167" "False" "High" "IsMasterProtein" "Q9Y3E1" "Hepatoma-derived growth factor-related protein 3 OS=Homo sapiens OX=9606 GN=HDGFL3 PE=1 SV=1" "0.000" "False" "5.398" "8" "2" "4" "1" "203" "22.6" "7.99" "11.54" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00855" "50810" "ENSG00000166503" "HDGFL3" "hsa:50810; Q9Y3E1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939806081474713784" "False" "High" "IsMasterProtein" "Q9Y586" "Protein mab-21-like 2 OS=Homo sapiens OX=9606 GN=MAB21L2 PE=1 SV=1" "0.000" "False" "5.387" "5" "2" "2" "2" "359" "40.9" "8.56" "5.56" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf03281, Pf20266" "10586" "ENSG00000181541" "MAB21L2" "B3KP37; hsa:10586; Q9HBA7; Q9Y586" "" "" "0" "0" "0.869" "1.121" "1.070" "1.013" "0.906" "0.853" "0.949" "0.935" "0.922" "67.9" "59.0" "76.1" "72.6" "68.8" "61.5" "58.0" "64.4" "63.5" "62.6" "" "" "" "" "" "" "" "" "" "" "54.5" "42.6" "60.5" "48.7" "47.6" "46.1" "40.6" "47.1" "63.5" "50.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262734157985051002" "False" "High" "IsMasterProtein" "Q9H7H0" "Ribosome assembly protein METTL17, mitochondrial OS=Homo sapiens OX=9606 GN=METTL17 PE=1 SV=1" "0.000" "False" "5.385" "5" "2" "2" "2" "456" "50.7" "9.33" "6.26" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf09243" "64745" "ENSG00000165792" "METTL17" "hsa:64745; Q9BSH1; Q9BZH2; Q9BZH3; Q9H7H0" "" "" "0" "0" "1.177" "1.256" "1.371" "1.326" "1.244" "1.284" "1.294" "1.290" "1.419" "78.5" "92.4" "98.5" "107.5" "104.1" "97.6" "100.7" "101.5" "101.2" "111.3" "" "" "" "" "" "" "" "" "" "" "63.0" "66.7" "78.3" "72.0" "72.0" "73.2" "70.5" "74.1" "101.2" "90.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410624310622087342" "False" "High" "IsMasterProtein" "Q13227" "G protein pathway suppressor 2 OS=Homo sapiens OX=9606 GN=GPS2 PE=1 SV=3" "0.000" "False" "5.371" "5" "2" "2" "2" "327" "36.7" "9.52" "5.99" "2" "stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15991" "2874" "ENSG00000132522; ENSG00000288325" "GPS2" "B4DXA1; hsa:2874; Q13227; Q6FHM8" "HDACs deacetylate histones; PPARA activates gene expression; HCMV Early Events; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "Rett syndrome" "7" "0" "0.854" "0.837" "0.977" "0.948" "1.146" "0.829" "0.908" "0.890" "1.052" "54.0" "46.1" "45.2" "52.8" "51.2" "61.9" "44.7" "49.0" "48.0" "56.8" "" "" "" "" "" "" "" "" "" "" "43.4" "33.3" "35.9" "35.3" "35.4" "46.4" "31.3" "35.8" "48.0" "46.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7298990959993915451" "False" "High" "IsMasterProtein" "Q96SD1" "Protein artemis OS=Homo sapiens OX=9606 GN=DCLRE1C PE=1 SV=2" "0.000" "False" "5.357" "1" "1" "1" "1" "692" "78.4" "6.02" "4.09" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07522" "64421" "ENSG00000152457" "DCLRE1C" "D3DRT6; hsa:64421; Q1HCL2; Q5JSR4; Q5JSR5; Q5JSR7; Q5JSR8; Q5JSR9; Q5JSS0; Q5JSS7; Q6PK14; Q8N101; Q8N132; Q8TBW9; Q96SD1; Q9BVW9; Q9HAM4" "Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; Non-homologous end joining; DNA repair pathways, full network" "4" "0" "1.067" "0.967" "1.037" "1.102" "1.038" "0.934" "0.922" "1.100" "1.110" "171.0" "182.4" "165.3" "177.3" "188.4" "177.6" "159.6" "157.6" "188.1" "189.8" "" "" "" "" "" "" "" "" "" "" "137.4" "131.6" "131.3" "118.8" "130.3" "133.2" "111.8" "115.1" "188.1" "154.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1103469562335054989" "False" "High" "IsMasterProtein" "Q8WUF8" "Cotranscriptional regulator ARB2A OS=Homo sapiens OX=9606 GN=ARB2A PE=1 SV=1" "0.000" "False" "5.348" "4" "1" "1" "1" "416" "47.9" "6.09" "2.85" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "" "Pf09757" "83989" "ENSG00000113391" "ARB2A" "B2R7C6; B4DJ14; B4DLG5; hsa:83989; Q8WUF8; Q9H0U8" "" "" "0" "0" "1.104" "1.110" "0.974" "1.023" "1.095" "0.983" "0.998" "0.979" "1.044" "54.1" "59.8" "60.1" "52.7" "55.3" "59.2" "53.2" "54.0" "53.0" "56.5" "" "" "" "" "" "" "" "" "" "" "43.5" "43.1" "47.7" "35.3" "38.3" "44.4" "37.3" "39.5" "53.0" "45.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377867133964341860" "False" "High" "IsMasterProtein" "P02656" "Apolipoprotein C-III OS=Homo sapiens OX=9606 GN=APOC3 PE=1 SV=1" "0.000" "False" "5.340" "16" "1" "1" "1" "99" "10.8" "5.41" "4.21" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf05778" "345" "ENSG00000110245" "APOC3" "hsa:345; P02656; Q08E83; Q6Q786" "Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling; HDL remodeling" "PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Cholesterol metabolism" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5340493121731341937" "False" "High" "IsMasterProtein" "Q9BQD3" "KxDL motif-containing protein 1 OS=Homo sapiens OX=9606 GN=KXD1 PE=1 SV=2" "0.000" "False" "5.338" "10" "2" "2" "2" "176" "19.7" "4.89" "4.52" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10241" "79036" "ENSG00000105700" "KXD1" "O76098; Q9BQD3" "" "" "0" "0" "1.041" "1.043" "1.126" "1.088" "1.037" "1.119" "1.078" "1.063" "0.956" "108.6" "113.1" "113.2" "122.3" "118.2" "112.6" "121.5" "117.1" "115.4" "103.9" "" "" "" "" "" "" "" "" "" "" "87.2" "81.6" "89.9" "81.9" "81.8" "84.5" "85.1" "85.5" "115.4" "84.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "62190601314665841" "False" "High" "IsMasterProtein" "Q14207" "Protein NPAT OS=Homo sapiens OX=9606 GN=NPAT PE=1 SV=3" "0.000" "False" "5.337" "1" "2" "2" "2" "1427" "154.2" "5.88" "5.76" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15712" "4863" "ENSG00000149308" "NPAT" "A8K1V5; A8K6M2; hsa:4863; Q13632; Q14207; Q14967; Q16580; Q86W55; Q8IWE9" "" "Retinoblastoma gene in cancer" "1" "0" "1.034" "1.000" "1.174" "0.931" "1.042" "1.369" "1.414" "1.304" "0.974" "36.9" "38.1" "36.9" "43.3" "34.3" "38.4" "50.5" "52.1" "48.1" "35.9" "" "" "" "" "" "" "" "" "" "" "29.6" "27.5" "29.3" "29.0" "23.7" "28.8" "35.4" "38.1" "48.1" "29.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4171853106673834253" "False" "High" "IsMasterProtein" "Q9BVV6" "Protein TALPID3 OS=Homo sapiens OX=9606 GN=KIAA0586 PE=1 SV=4" "0.000" "False" "5.336" "1" "1" "1" "1" "1533" "169.2" "5.54" "4.03" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;other cell component" "" "Pf15324" "9786" "ENSG00000100578" "KIAA0586" "B4DZB6; E7EWM8; hsa:9786; J3KQH9; O60328; Q6NYC6; Q6UV20; Q9BVV6" "" "Joubert syndrome; Ciliopathies" "2" "0" "1.014" "0.955" "1.077" "0.885" "1.008" "1.102" "1.041" "1.164" "0.817" "47.4" "48.1" "45.3" "51.1" "41.9" "47.8" "52.2" "49.3" "55.1" "38.7" "" "" "" "" "" "" "" "" "" "" "38.1" "34.7" "36.0" "34.2" "29.0" "35.8" "36.6" "36.0" "55.1" "31.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1389004706389112058" "False" "High" "IsMasterProtein" "Q5PSV4" "Breast cancer metastasis-suppressor 1-like protein OS=Homo sapiens OX=9606 GN=BRMS1L PE=1 SV=2" "0.000" "False" "5.325" "5" "2" "2" "2" "323" "37.6" "5.15" "6.04" "2" "other biological processes" "nucleus" "other molecular function" "Pf08598" "84312" "ENSG00000100916" "BRMS1L" "A6NFW5; A6NH45; B2RD65; hsa:84312; Q5PSV4; Q9BRI4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3980929608971317432" "False" "High" "IsMasterProtein" "Q9UGN5" "Poly [ADP-ribose] polymerase 2 OS=Homo sapiens OX=9606 GN=PARP2 PE=1 SV=2" "0.000" "False" "5.309" "4" "2" "2" "2" "583" "66.2" "8.88" "5.02" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00644, Pf02877, Pf05406" "10038" "ENSG00000129484; ENSG00000291803" "PARP2" "hsa:10038; Q8TEU4; Q9NUV2; Q9UGN5; Q9UMR4; Q9Y6C8" "Dual Incision in GG-NER; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; HDR through MMEJ (alt-NHEJ); POLB-Dependent Long Patch Base Excision Repair" "NAD+ biosynthetic pathways; Base excision repair; Peroxiredoxin 2 induced ovarian failure; DNA repair pathways, full network" "9" "0" "0.856" "0.805" "1.227" "0.900" "1.028" "1.045" "1.007" "0.807" "0.877" "28.9" "24.7" "23.2" "35.4" "26.0" "29.7" "30.2" "29.1" "23.3" "25.3" "" "" "" "" "" "" "" "" "" "" "23.2" "17.8" "18.5" "23.7" "18.0" "22.3" "21.1" "21.2" "23.3" "20.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8182350314247288702" "False" "High" "IsMasterProtein" "Q9NVQ4" "Fas apoptotic inhibitory molecule 1 OS=Homo sapiens OX=9606 GN=FAIM PE=1 SV=1" "0.000" "False" "5.308" "5" "1" "2" "1" "179" "20.2" "5.83" "6.52" "1" "signal transduction;other biological processes" "other cell component" "" "Pf06905" "55179" "ENSG00000158234" "FAIM" "hsa:55179; Q6IAN2; Q9NVQ4" "" "Neurogenesis regulation in the olfactory epithelium" "1" "0" "1.063" "1.105" "0.805" "0.944" "1.027" "0.888" "0.936" "0.996" "0.990" "208.4" "221.4" "230.3" "167.8" "196.7" "214.0" "185.0" "195.0" "207.6" "206.4" "" "" "" "" "" "" "" "" "" "" "167.4" "159.8" "182.9" "112.4" "136.0" "160.5" "129.5" "142.4" "207.6" "167.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7312432654099933298" "False" "High" "IsMasterProtein" "Q8WUF5" "RelA-associated inhibitor OS=Homo sapiens OX=9606 GN=PPP1R13L PE=1 SV=4" "0.000" "False" "5.303" "2" "2" "2" "2" "828" "89.0" "6.81" "5.75" "2" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12796, Pf14604" "10848" "ENSG00000104881" "PPP1R13L" "hsa:10848; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q8WUF5; Q9Y290" "Regulation of TP53 Activity through Association with Co-factors" "IL-18 signaling pathway" "2" "0" "0.951" "0.983" "1.177" "1.191" "0.926" "1.125" "1.105" "0.974" "1.166" "98.2" "93.4" "96.5" "115.6" "117.0" "91.0" "110.5" "108.5" "95.7" "114.5" "" "" "" "" "" "" "" "" "" "" "78.9" "67.4" "76.7" "77.5" "80.9" "68.2" "77.4" "79.2" "95.7" "93.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5995744781224398015" "False" "High" "IsMasterProtein" "P10746" "Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1" "0.000" "False" "5.303" "4" "1" "1" "1" "265" "28.6" "5.48" "3.49" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf02602" "7390" "ENSG00000188690" "UROS" "B2RC13; D3DRF7; hsa:7390; P10746; Q9H2T1" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "0.901" "0.908" "0.881" "0.942" "0.920" "0.961" "0.980" "0.947" "0.897" "91.7" "82.6" "83.3" "80.8" "86.3" "84.3" "88.1" "89.8" "86.8" "82.2" "" "" "" "" "" "" "" "" "" "" "73.6" "59.6" "66.1" "54.1" "59.7" "63.3" "61.7" "65.6" "86.8" "66.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3859888159614048527" "False" "High" "IsMasterProtein" "Q9NRP4" "Succinate dehydrogenase assembly factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF3 PE=1 SV=1" "0.000" "False" "5.297" "7" "1" "1" "1" "125" "14.6" "9.07" "3.28" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "mitochondrion" "" "Pf13233" "57001" "ENSG00000196636" "SDHAF3" "A4D1J3; hsa:57001; Q75MD6; Q9NRP4" "" "Mitochondrial complex II assembly" "1" "0" "0.991" "0.916" "1.001" "0.910" "1.004" "0.984" "0.650" "0.911" "0.972" "66.3" "65.7" "60.7" "66.3" "60.3" "66.5" "65.3" "43.1" "60.4" "64.5" "" "" "" "" "" "" "" "" "" "" "53.3" "47.4" "48.2" "44.4" "41.7" "49.9" "45.7" "31.5" "60.4" "52.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199691320641439357" "False" "High" "IsMasterProtein" "Q9Y2M5" "Kelch-like protein 20 OS=Homo sapiens OX=9606 GN=KLHL20 PE=1 SV=4" "0.000" "False" "5.295" "2" "1" "1" "1" "609" "67.9" "6.87" "3.14" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00651, Pf01344, Pf07707" "27252" "ENSG00000076321" "KLHL20" "B3KMA0; B4DUR0; hsa:27252; Q5TZF2; Q5ZF45; Q9H457; Q9Y2M5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.260" "1.149" "1.188" "1.370" "1.289" "1.391" "1.551" "1.294" "1.394" "38.9" "49.0" "44.7" "46.2" "53.3" "50.1" "54.1" "60.3" "50.3" "54.2" "" "" "" "" "" "" "" "" "" "" "31.2" "35.4" "35.5" "31.0" "36.9" "37.6" "37.9" "44.1" "50.3" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3653406019681218238" "False" "High" "IsMasterProtein" "Q07002" "Cyclin-dependent kinase 18 OS=Homo sapiens OX=9606 GN=CDK18 PE=1 SV=4" "0.000" "False" "5.292" "4" "2" "4" "1" "474" "54.4" "8.66" "9.12" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5129" "ENSG00000117266" "CDK18" "hsa:5129; Q07002; Q5VXQ2; Q6V3A2; Q6V3A3; Q96F90" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2365536484352978519" "False" "High" "IsMasterProtein" "Q8N5C7" "tRNA-uridine aminocarboxypropyltransferase 1 OS=Homo sapiens OX=9606 GN=DTWD1 PE=1 SV=1" "0.000" "False" "5.277" "5" "1" "1" "1" "304" "35.2" "8.38" "2.09" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf03942" "56986" "ENSG00000104047" "DTWD1" "hsa:56986; Q567Q3; Q8N5C7; Q8WVG9; Q9NRU6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6741230016500907369" "False" "High" "IsMasterProtein" "A6NMY6" "Putative annexin A2-like protein OS=Homo sapiens OX=9606 GN=ANXA2P2 PE=5 SV=2" "0.000" "False" "5.275" "3" "1" "1" "1" "339" "38.6" "6.95" "4.31" "1" "transport" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00191" "" "" "ANXA2P2" "A6NMY6" "" "" "0" "0" "0.959" "0.615" "0.760" "1.019" "0.918" "1.554" "0.866" "0.897" "0.888" "122.3" "117.3" "75.2" "93.0" "124.6" "112.2" "190.1" "105.9" "109.7" "108.6" "" "" "" "" "" "" "" "" "" "" "98.2" "84.6" "59.7" "62.3" "86.2" "84.2" "133.1" "77.3" "109.7" "88.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2083530276327625921" "False" "High" "IsMasterProtein" "Q9BUW7" "Bublin coiled-coil protein OS=Homo sapiens OX=9606 GN=BBLN PE=1 SV=1" "0.000" "False" "5.275" "19" "1" "2" "1" "83" "9.0" "4.22" "6.02" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "other molecular function" "Pf03670" "79095" "ENSG00000171159" "BBLN" "hsa:79095; Q5SYV8; Q9BUW7; Q9Y3F7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021135707239228724" "False" "High" "IsMasterProtein" "Q92664" "Transcription factor IIIA OS=Homo sapiens OX=9606 GN=GTF3A PE=1 SV=3" "0.000" "False" "5.243" "4" "2" "3" "2" "365" "41.5" "9.14" "9.52" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "2971" "ENSG00000122034" "GTF3A" "B7ZBK5; hsa:2971; Q12963; Q13097; Q92664" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter" "Adipogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-530049988606756436" "False" "High" "IsMasterProtein" "Cont_P01030" "Complement C4 (Fragments) OS=Bos taurus OX=9913 GN=C4 PE=1 SV=2" "0.000" "True" "5.238" "2" "2" "2" "1" "920" "101.8" "6.58" "4.52" "2" "stress response;other biological processes" "non-structural extracellular;other cell component" "" "" "" "" "C4" "P01030; Q27992; Q27993" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "462176972851051990" "False" "High" "IsMasterProtein" "Q05513" "Protein kinase C zeta type OS=Homo sapiens OX=9606 GN=PRKCZ PE=1 SV=4" "0.000" "False" "5.230" "3" "3" "4" "1" "592" "67.6" "5.77" "5.66" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5590" "ENSG00000067606" "PRKCZ" "A8K4N0; A8MU64; B7Z2J7; E9PCW2; hsa:5590; Q05513; Q15207; Q5SYT5; Q969S4" "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); GPVI-mediated activation cascade; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; RHO GTPases Activate NADPH Oxidases" "Type II diabetes mellitus; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Myometrial relaxation and contraction pathways; G protein signaling pathways; Interleukin-1 induced activation of NF-kB; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Prader-Willi and Angelman syndrome; Splicing factor NOVA regulated synaptic proteins; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; 1p36 copy number variation syndrome; Calcium regulation in cardiac cells; HDAC6 interactions in the central nervous system" "31" "0" "1.262" "1.419" "1.478" "1.148" "1.235" "1.068" "1.037" "1.245" "1.448" "24.5" "30.9" "34.7" "36.2" "28.1" "30.2" "26.1" "25.4" "30.5" "35.4" "" "" "" "" "" "" "" "" "" "" "19.7" "22.3" "27.6" "24.2" "19.4" "22.7" "18.3" "18.5" "30.5" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3754382258737944185" "False" "High" "IsMasterProtein" "Q9Y546" "Leucine-rich repeat-containing protein 42 OS=Homo sapiens OX=9606 GN=LRRC42 PE=1 SV=1" "0.000" "False" "5.228" "4" "2" "2" "2" "428" "48.5" "7.46" "4.21" "2" "" "" "" "Pf13516" "115353" "ENSG00000116212" "LRRC42" "D3DQ46; hsa:115353; Q8N2Q8; Q9Y546" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3483870815456167383" "False" "High" "IsMasterProtein" "Q9NS28" "Regulator of G-protein signaling 18 OS=Homo sapiens OX=9606 GN=RGS18 PE=1 SV=1" "0.000" "False" "5.220" "7" "2" "2" "2" "235" "27.6" "7.91" "6.40" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "64407" "ENSG00000150681" "RGS18" "B2RD23; hsa:64407; Q9NS28" "G alpha (q) signalling events; G alpha (i) signalling events" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "4" "0" "0.999" "1.043" "0.959" "1.101" "1.075" "0.922" "1.106" "1.082" "1.066" "216.8" "216.7" "226.1" "208.0" "238.7" "233.2" "200.0" "239.9" "234.6" "231.1" "" "" "" "" "" "" "" "" "" "" "174.2" "156.3" "179.6" "139.4" "165.1" "175.0" "140.0" "175.2" "234.6" "188.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5269036548224773448" "False" "High" "IsMasterProtein" "Q6UXH1" "Protein disulfide isomerase CRELD2 OS=Homo sapiens OX=9606 GN=CRELD2 PE=1 SV=1" "0.000" "False" "5.201" "7" "2" "2" "2" "353" "38.2" "4.59" "3.00" "2" "" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf07645" "79174" "ENSG00000184164" "CRELD2" "A5GZA2; A5GZA3; A5GZA4; A5GZA5; A5GZA6; hsa:79174; Q4W0V0; Q6UXH1; Q86UC0; Q9BU47" "" "" "0" "0" "0.795" "1.131" "0.851" "1.038" "0.739" "0.980" "0.835" "1.161" "0.828" "161.9" "128.7" "183.2" "137.8" "168.1" "119.7" "158.7" "135.2" "188.0" "134.1" "" "" "" "" "" "" "" "" "" "" "130.1" "92.9" "145.5" "92.3" "116.3" "89.8" "111.1" "98.8" "188.0" "109.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1247972566185408077" "False" "High" "IsMasterProtein" "Q9UNT1" "Rab-like protein 2B OS=Homo sapiens OX=9606 GN=RABL2B PE=1 SV=1" "0.000" "False" "5.176" "7" "2" "2" "2" "228" "26.1" "4.89" "6.05" "2" "cell organization and biogenesis;transport" "cytoskeleton;other cell component" "other molecular function" "Pf00071" "11158" "ENSG00000079974" "RABL2B" "hsa:11158; Q5TZT8; Q96C33; Q9UNT1" "" "3q29 copy number variation syndrome" "1" "0" "0.965" "0.926" "0.782" "0.813" "0.914" "0.782" "0.894" "0.923" "0.850" "254.1" "245.2" "235.2" "198.8" "206.7" "232.2" "198.7" "227.1" "234.4" "216.0" "" "" "" "" "" "" "" "" "" "" "204.1" "177.0" "186.8" "133.2" "143.0" "174.2" "139.1" "165.8" "234.4" "175.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8412715806264131259" "False" "High" "IsMasterProtein" "Q5F1R6" "DnaJ homolog subfamily C member 21 OS=Homo sapiens OX=9606 GN=DNAJC21 PE=1 SV=2" "0.000" "False" "5.153" "5" "2" "3" "2" "531" "62.0" "5.47" "4.81" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00226, Pf12171" "134218" "ENSG00000168724" "DNAJC21" "Q3B7J9; Q5F1R6; Q6P086; Q6ZS43; Q86VC6" "" "" "0" "0" "0.927" "0.966" "1.198" "0.994" "1.395" "1.116" "0.874" "0.802" "1.234" "15.9" "14.8" "15.4" "19.1" "15.9" "22.2" "17.8" "13.9" "12.8" "19.7" "" "" "" "" "" "" "" "" "" "" "12.8" "10.7" "12.2" "12.8" "11.0" "16.7" "12.5" "10.2" "12.8" "16.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3309716213588487454" "False" "High" "IsMasterProtein" "Q659C4" "La-related protein 1B OS=Homo sapiens OX=9606 GN=LARP1B PE=1 SV=2" "0.000" "False" "5.139" "2" "2" "3" "1" "914" "105.3" "7.61" "7.66" "2" "other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383, Pf21071" "55132" "ENSG00000138709" "LARP1B" "hsa:55132; Q2YDB6; Q4W599; Q4W5B2; Q659A0; Q659C4; Q6P5X2; Q7Z3F7; Q86VK7; Q8N6F4; Q8N7H4; Q8NAF2; Q9H5E7; Q9NW12" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4008983294682530798" "False" "High" "IsMasterProtein" "Q9UBZ4" "DNA-(apurinic or apyrimidinic site) endonuclease 2 OS=Homo sapiens OX=9606 GN=APEX2 PE=1 SV=1" "0.000" "False" "5.133" "4" "2" "2" "2" "518" "57.4" "8.29" "4.64" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf06839" "27301" "ENSG00000169188" "APEX2" "hsa:27301; Q9UBZ4; Q9Y5X7" "" "Base excision repair; DNA repair pathways, full network" "2" "0" "1.226" "1.225" "1.487" "1.254" "1.289" "1.469" "1.306" "1.419" "1.256" "73.4" "90.0" "90.0" "109.2" "92.1" "94.7" "107.8" "95.9" "104.2" "92.3" "" "" "" "" "" "" "" "" "" "" "59.0" "65.0" "71.5" "73.2" "63.7" "71.0" "75.5" "70.0" "104.2" "75.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "776622353869952197" "False" "High" "IsMasterProtein" "O60262" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 OS=Homo sapiens OX=9606 GN=GNG7 PE=1 SV=1" "0.000" "False" "5.122" "21" "1" "2" "1" "68" "7.5" "8.51" "7.45" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2788" "ENSG00000176533" "GNG7" "B2R496; hsa:2788; O60262" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643865994575879356" "False" "High" "IsMasterProtein" "Q7Z6M4" "Transcription termination factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF4 PE=1 SV=3" "0.000" "False" "5.120" "3" "1" "1" "1" "381" "43.9" "4.82" "2.97" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf02536" "130916" "ENSG00000122085" "MTERF4" "A8K6K0; hsa:130916; Q7Z6M4; Q9P0E0" "rRNA modification in the mitochondrion" "CCL18 signaling pathway; 2q37 copy number variation syndrome" "3" "0" "0.995" "0.849" "0.938" "0.748" "0.889" "0.917" "0.913" "0.935" "0.863" "41.8" "41.6" "35.5" "39.2" "31.3" "37.2" "38.3" "38.2" "39.1" "36.1" "" "" "" "" "" "" "" "" "" "" "33.6" "30.0" "28.2" "26.3" "21.6" "27.9" "26.8" "27.9" "39.1" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5033064795013952136" "False" "High" "IsMasterProtein" "Q86X40" "Leucine-rich repeat-containing protein 28 OS=Homo sapiens OX=9606 GN=LRRC28 PE=1 SV=1" "0.000" "False" "5.112" "6" "2" "2" "2" "367" "41.9" "7.94" "5.18" "2" "signal transduction" "" "" "Pf13855" "123355" "ENSG00000168904" "LRRC28" "A8KA22; hsa:123355; Q6UY49; Q6ZSS6; Q86X40" "" "" "0" "0" "1.236" "0.816" "1.091" "1.238" "0.893" "1.031" "1.120" "0.950" "1.051" "66.1" "81.7" "54.0" "72.2" "81.8" "59.0" "68.2" "74.1" "62.8" "69.5" "" "" "" "" "" "" "" "" "" "" "53.1" "59.0" "42.9" "48.4" "56.6" "44.3" "47.7" "54.1" "62.8" "56.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4054335882506265826" "False" "High" "IsMasterProtein" "Q8TE73" "Dynein axonemal heavy chain 5 OS=Homo sapiens OX=9606 GN=DNAH5 PE=1 SV=3" "0.000" "False" "5.110" "0" "2" "2" "1" "4624" "528.7" "6.10" "3.24" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf17857, Pf18198, Pf18199" "1767" "ENSG00000039139" "DNAH5" "hsa:1767; Q8TE73; Q92860; Q96L74; Q9H5S7; Q9HCG9" "" "" "0" "0" "1.045" "0.880" "0.974" "0.864" "1.048" "0.690" "1.027" "0.883" "0.801" "23.2" "24.2" "20.4" "22.6" "20.0" "24.3" "16.0" "23.8" "20.5" "18.6" "" "" "" "" "" "" "" "" "" "" "18.6" "17.5" "16.2" "15.1" "13.9" "18.2" "11.2" "17.4" "20.5" "15.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314014285931232470" "False" "High" "IsMasterProtein" "P18124" "Large ribosomal subunit protein uL30 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "0.000" "False" "5.108" "5" "1" "2" "1" "248" "29.2" "10.65" "6.02" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.822" "1.187" "1.200" "1.053" "1.254" "0.812" "0.895" "1.090" "0.869" "50.9" "41.9" "60.5" "61.1" "53.6" "63.9" "41.4" "45.6" "55.5" "44.3" "" "" "" "" "" "" "" "" "" "" "40.9" "30.2" "48.0" "41.0" "37.1" "47.9" "29.0" "33.3" "55.5" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579603406694116788" "False" "High" "IsMasterProtein" "Q9H0C5" "BTB/POZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BTBD1 PE=1 SV=1" "0.000" "False" "5.104" "4" "2" "2" "1" "482" "52.7" "6.10" "3.99" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf07707, Pf08005" "53339" "ENSG00000064726" "BTBD1" "A6NMI8; hsa:53339; Q9BX71; Q9H0C5; Q9NWN4" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "15q25 copy number variation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245532746290238029" "False" "High" "IsMasterProtein" "P61353" "Large ribosomal subunit protein eL27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2" "0.000" "False" "5.099" "7" "1" "2" "1" "136" "15.8" "10.56" "3.95" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00467, Pf01777" "6155" "ENSG00000131469" "RPL27" "hsa:6155; P08526; P61353; Q4G0A9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "1.035" "1.153" "1.190" "1.180" "1.091" "1.218" "1.215" "1.182" "1.121" "349.7" "362.0" "403.1" "416.2" "412.6" "381.4" "425.8" "424.9" "413.3" "392.1" "" "" "" "" "" "" "" "" "" "" "280.8" "261.2" "320.2" "278.9" "285.4" "286.1" "298.1" "310.3" "413.3" "318.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-102790818838241857" "False" "High" "IsMasterProtein" "O94875" "Sorbin and SH3 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SORBS2 PE=1 SV=3" "0.000" "False" "5.098" "1" "1" "1" "1" "1100" "124.0" "8.31" "4.03" "1" "cell organization and biogenesis;developmental processes;signal transduction" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02208, Pf14604" "8470" "ENSG00000154556" "SORBS2" "A6NEK9; B3KPQ7; B7Z1G5; B7Z3X6; C9JKV9; D3DP62; D3DP63; E9PAS5; E9PAW4; G3XAI0; H7BXR4; hsa:8470; J3KNZ5; O60592; O60593; O94875; Q96EX0" "" "Extracellular vesicles in the crosstalk of cardiac cells" "1" "0" "1.002" "0.961" "0.956" "0.906" "0.805" "0.842" "0.971" "1.021" "0.897" "67.2" "67.3" "64.5" "64.2" "60.8" "54.1" "56.6" "65.2" "68.6" "60.2" "" "" "" "" "" "" "" "" "" "" "54.0" "48.6" "51.3" "43.0" "42.1" "40.6" "39.6" "47.6" "68.6" "49.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945830629131727042" "False" "High" "IsMasterProtein" "Q8NFG4" "Folliculin OS=Homo sapiens OX=9606 GN=FLCN PE=1 SV=1" "0.000" "False" "5.095" "2" "1" "1" "1" "579" "64.4" "6.23" "3.19" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf11704, Pf16692" "201163" "ENSG00000154803" "FLCN" "A6NJJ8; hsa:201163; Q6ZRX1; Q8NFG4; Q96BD2; Q96BE4" "Amino acids regulate mTORC1" "Ciliopathies; Bardet-Biedl syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "4" "0" "0.984" "0.748" "1.014" "1.232" "1.279" "1.255" "1.002" "1.029" "0.923" "21.1" "20.8" "15.8" "21.4" "26.0" "27.0" "26.5" "21.1" "21.7" "19.5" "" "" "" "" "" "" "" "" "" "" "16.9" "15.0" "12.5" "14.3" "18.0" "20.3" "18.5" "15.4" "21.7" "15.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354305271704446850" "False" "High" "IsMasterProtein" "O95248" "Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4" "0.000" "False" "5.090" "1" "1" "1" "1" "1868" "208.3" "6.90" "3.03" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "6305" "ENSG00000100241" "SBF1" "A0A024R4Z9; A6PVG9; G5E933; hsa:6305; O60228; O95248; Q5JXD8; Q5PPM2; Q96GR9; Q9UGB8" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the ER membrane" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010506436641867552" "False" "High" "IsMasterProtein" "Q8WWW0" "Ras association domain-containing protein 5 OS=Homo sapiens OX=9606 GN=RASSF5 PE=1 SV=1" "0.000" "False" "5.089" "3" "1" "1" "1" "418" "47.1" "9.14" "4.24" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00130, Pf00788, Pf16517" "83593" "ENSG00000266094" "RASSF5" "A8K1E6; hsa:83593; Q5SY32; Q8WWV9; Q8WWW0; Q8WXF4; Q9BT99" "" "Fibrin complement receptor 3 signaling pathway; Ras signaling; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "5" "0" "0.987" "0.949" "0.878" "1.087" "0.949" "0.885" "0.995" "1.012" "1.014" "139.4" "137.6" "132.2" "122.4" "151.5" "132.3" "123.3" "138.7" "141.1" "141.4" "" "" "" "" "" "" "" "" "" "" "111.9" "99.3" "105.0" "82.0" "104.8" "99.3" "86.3" "101.3" "141.1" "115.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2072306986524889695" "False" "High" "IsMasterProtein" "Q8WVD3" "E3 ubiquitin-protein ligase RNF138 OS=Homo sapiens OX=9606 GN=RNF138 PE=1 SV=1" "0.000" "False" "5.084" "8" "2" "2" "2" "245" "28.2" "6.93" "6.09" "2" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05605, Pf13923, Pf18574" "51444" "ENSG00000134758" "RNF138" "B2RE17; hsa:51444; Q8WVD3; Q9H8K2; Q9UF87; Q9UKI6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.010" "1.055" "1.047" "1.394" "1.020" "1.115" "1.307" "1.201" "1.201" "53.3" "53.9" "56.3" "55.8" "74.3" "54.4" "59.5" "69.7" "64.0" "64.0" "" "" "" "" "" "" "" "" "" "" "42.8" "38.9" "44.7" "37.4" "51.4" "40.8" "41.6" "50.9" "64.0" "52.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5592449745449549244" "False" "High" "IsMasterProtein" "Q8WUK0" "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Homo sapiens OX=9606 GN=PTPMT1 PE=1 SV=1" "0.000" "False" "5.039" "8" "2" "2" "2" "201" "22.8" "9.77" "5.62" "2" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00782" "114971" "ENSG00000110536" "PTPMT1" "E9PAT8; hsa:114971; Q7Z557; Q8WUK0; Q96CR2; Q9BXV8" "Synthesis of PG" "7q11.23 distal copy number variation" "2" "0" "1.014" "1.007" "1.137" "1.200" "1.097" "1.095" "1.143" "1.092" "1.208" "365.3" "370.2" "367.6" "415.2" "438.4" "400.8" "400.1" "417.6" "398.9" "441.3" "" "" "" "" "" "" "" "" "" "" "293.4" "267.1" "292.0" "278.2" "303.2" "300.7" "280.1" "305.0" "398.9" "358.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3299789878161975877" "False" "High" "IsMasterProtein" "Q76L83" "Putative Polycomb group protein ASXL2 OS=Homo sapiens OX=9606 GN=ASXL2 PE=1 SV=1" "0.000" "False" "5.039" "2" "2" "2" "2" "1435" "153.7" "8.81" "5.41" "2" "other biological processes" "nucleus" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05066, Pf13919, Pf13922" "55252" "ENSG00000143970" "ASXL2" "hsa:55252; Q53TC9; Q5H9U4; Q76L81; Q76L83; Q86XM1; Q9C0H8; Q9NV67" "UCH proteinases" "" "1" "0" "1.018" "1.087" "1.207" "1.310" "0.967" "1.086" "0.935" "1.089" "1.043" "30.0" "30.6" "32.6" "36.2" "39.4" "29.0" "32.6" "28.1" "32.7" "31.3" "" "" "" "" "" "" "" "" "" "" "24.1" "22.1" "25.9" "24.3" "27.2" "21.8" "22.8" "20.5" "32.7" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1299215584084045003" "False" "High" "IsMasterProtein" "Q9BRQ3" "Uridine diphosphate glucose pyrophosphatase NUDT22 OS=Homo sapiens OX=9606 GN=NUDT22 PE=1 SV=3" "0.000" "False" "5.029" "4" "1" "1" "1" "303" "32.6" "5.11" "4.00" "1" "" "nucleus" "other molecular function" "" "84304" "ENSG00000149761" "NUDT22" "C9JY06; hsa:84304; Q71RD5; Q9BRQ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8558534356578167804" "False" "High" "IsMasterProtein" "Q9H5U6" "rRNA N6-adenosine-methyltransferase ZCCHC4 OS=Homo sapiens OX=9606 GN=ZCCHC4 PE=1 SV=3" "0.000" "False" "5.028" "4" "2" "2" "2" "513" "59.0" "8.75" "3.70" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06839, Pf10237" "29063" "ENSG00000168228" "ZCCHC4" "B2RXF6; B4DRD8; B7ZW20; hsa:29063; Q5IW78; Q96AN7; Q9H5U6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1865861446448502197" "False" "High" "IsMasterProtein" "Q9Y2U9" "Kelch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KLHDC2 PE=1 SV=1" "0.000" "False" "5.025" "5" "2" "2" "2" "406" "46.1" "6.61" "5.34" "2" "protein metabolism;other metabolic processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf13418" "23588" "ENSG00000165516" "KLHDC2" "B3KPF9; hsa:23588; Q6IAF0; Q86TY9; Q9Y2U9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2682547924160316204" "False" "High" "IsMasterProtein" "Q8WVD5" "RING finger protein 141 OS=Homo sapiens OX=9606 GN=RNF141 PE=1 SV=1" "0.000" "False" "5.017" "4" "1" "1" "1" "230" "25.5" "5.20" "2.91" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes" "other molecular function" "Pf13639" "50862" "ENSG00000110315" "RNF141" "A8K149; hsa:50862; Q8WVD5; Q9NZB4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6116188343313863326" "False" "High" "IsMasterProtein" "Q6P1L8" "Large ribosomal subunit protein uL14m OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1" "0.000" "False" "5.010" "7" "1" "1" "1" "145" "15.9" "10.24" "4.44" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00238" "64928" "ENSG00000180992" "MRPL14" "B2R575; hsa:64928; Q6P1L8; Q96Q72" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.001" "1.036" "1.088" "1.097" "0.872" "1.028" "1.227" "1.043" "1.033" "286.0" "286.4" "296.4" "311.2" "313.9" "249.4" "294.0" "350.8" "298.3" "295.4" "" "" "" "" "" "" "" "" "" "" "229.7" "206.7" "235.4" "208.5" "217.1" "187.1" "205.9" "256.2" "298.3" "240.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1053300951170364696" "False" "High" "IsMasterProtein" "Q9UIG0" "Tyrosine-protein kinase BAZ1B OS=Homo sapiens OX=9606 GN=BAZ1B PE=1 SV=2" "0.000" "False" "5.005" "1" "2" "2" "2" "1483" "170.8" "8.48" "2.26" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf00628, Pf10537, Pf15612, Pf15613" "9031" "ENSG00000009954" "BAZ1B" "B9EGK3; D3DXE9; hsa:9031; O95039; O95247; O95277; Q6P1K4; Q86UJ6; Q9UIG0" "B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome" "5" "0" "1.024" "0.975" "0.922" "0.963" "1.016" "0.929" "1.088" "1.016" "0.992" "146.4" "149.8" "142.7" "134.9" "140.9" "148.7" "135.9" "159.3" "148.7" "145.3" "" "" "" "" "" "" "" "" "" "" "117.6" "108.1" "113.4" "90.4" "97.4" "111.6" "95.2" "116.3" "148.7" "118.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1410222954037487144" "False" "High" "IsMasterProtein" "Q9BSK4" "Protein fem-1 homolog A OS=Homo sapiens OX=9606 GN=FEM1A PE=1 SV=1" "0.000" "False" "5.002" "3" "1" "1" "1" "669" "73.6" "6.07" "4.47" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf12796" "55527" "ENSG00000141965" "FEM1A" "B2RDI3; hsa:55527; Q711P8; Q9BSK4; Q9NPN7; Q9NPW8" "Neddylation" "" "1" "0" "0.871" "0.794" "1.085" "0.819" "0.959" "0.873" "1.012" "0.866" "0.756" "55.8" "48.6" "44.3" "60.5" "45.7" "53.5" "48.7" "56.4" "48.3" "42.2" "" "" "" "" "" "" "" "" "" "" "44.8" "35.1" "35.2" "40.5" "31.6" "40.1" "34.1" "41.2" "48.3" "34.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723203762439641288" "False" "High" "IsMasterProtein" "Q9Y5N5" "Methyltransferase N6AMT1 OS=Homo sapiens OX=9606 GN=N6AMT1 PE=1 SV=4" "0.000" "False" "4.986" "9" "2" "2" "2" "214" "22.9" "5.11" "4.40" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29104" "ENSG00000156239" "N6AMT1" "B2RA97; hsa:29104; Q96F73; Q9Y5N5" "Eukaryotic Translation Termination; Methylation" "" "2" "0" "1.184" "0.914" "1.579" "1.002" "0.881" "1.468" "0.693" "0.943" "1.023" "50.7" "60.0" "46.3" "80.0" "50.8" "44.6" "74.4" "35.1" "47.8" "51.8" "" "" "" "" "" "" "" "" "" "" "40.7" "43.3" "36.8" "53.6" "35.1" "33.5" "52.1" "25.6" "47.8" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "859606760973151215" "False" "High" "IsMasterProtein" "Q562F6" "Shugoshin 2 OS=Homo sapiens OX=9606 GN=SGO2 PE=1 SV=2" "0.000" "False" "4.984" "1" "1" "1" "1" "1265" "144.7" "7.91" "3.29" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "" "151246" "ENSG00000163535" "SGO2" "hsa:151246; Q53RR9; Q53T20; Q562F6; Q86XY4; Q8IWK2; Q8IZK1; Q8N1Q5; Q96LQ3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cohesin complex - Cornelia de Lange syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5489281537849050427" "False" "High" "IsMasterProtein" "Q9UEU0" "Vesicle transport through interaction with t-SNAREs homolog 1B OS=Homo sapiens OX=9606 GN=VTI1B PE=1 SV=3" "0.000" "False" "4.973" "5" "1" "1" "1" "232" "26.7" "9.04" "3.78" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "10490" "ENSG00000100568" "VTI1B" "hsa:10490; O43547; Q96J28; Q9UEU0" "Platelet degranulation" "" "1" "0" "1.007" "0.967" "1.261" "1.437" "0.871" "1.203" "1.236" "1.285" "1.546" "27.0" "27.2" "26.1" "34.1" "38.8" "23.5" "32.5" "33.4" "34.7" "41.8" "" "" "" "" "" "" "" "" "" "" "21.7" "19.6" "20.8" "22.8" "26.9" "17.7" "22.8" "24.4" "34.7" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8182942281364866985" "False" "High" "IsMasterProtein" "Q8NEM0" "Microcephalin OS=Homo sapiens OX=9606 GN=MCPH1 PE=1 SV=4" "0.000" "False" "4.956" "2" "2" "2" "2" "835" "92.8" "8.25" "3.51" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12258, Pf12738" "79648" "ENSG00000147316" "MCPH1" "A0A075B6F8; B4DWW2; E9PGU5; E9PH63; hsa:79648; Q66GU1; Q8NEM0; Q9H9C7" "Condensation of Prophase Chromosomes" "" "1" "0" "1.071" "0.969" "0.886" "1.003" "0.932" "1.146" "1.168" "1.137" "1.036" "242.8" "260.0" "235.2" "215.2" "243.7" "226.3" "278.4" "283.7" "276.1" "251.7" "" "" "" "" "" "" "" "" "" "" "195.0" "187.6" "186.9" "144.2" "168.5" "169.8" "194.9" "207.2" "276.1" "204.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986352754293277242" "False" "High" "IsMasterProtein" "P61513" "Large ribosomal subunit protein eL43 OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2" "0.000" "False" "4.955" "10" "2" "2" "2" "92" "10.3" "10.43" "6.20" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01780" "6168" "ENSG00000197756" "RPL37A" "hsa:6168; P12751; P61513; Q6FGF5" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Selenocysteine synthesis; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.950" "1.057" "1.049" "1.054" "1.147" "1.075" "0.962" "1.065" "1.122" "325.8" "309.5" "344.5" "341.7" "343.6" "373.6" "350.2" "313.6" "347.2" "365.6" "" "" "" "" "" "" "" "" "" "" "261.7" "223.3" "273.7" "228.9" "237.6" "280.3" "245.2" "229.0" "347.2" "297.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8613494787005004283" "False" "High" "IsMasterProtein" "Q9BWJ5" "Splicing factor 3B subunit 5 OS=Homo sapiens OX=9606 GN=SF3B5 PE=1 SV=1" "0.000" "False" "4.953" "26" "2" "2" "2" "86" "10.1" "6.35" "5.04" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07189" "83443" "ENSG00000169976" "SF3B5" "B2R568; hsa:83443; Q7RTV1; Q9BWJ5" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827069170954705052" "False" "High" "IsMasterProtein" "Q9UKJ3" "G patch domain-containing protein 8 OS=Homo sapiens OX=9606 GN=GPATCH8 PE=1 SV=2" "0.000" "False" "4.947" "1" "2" "2" "2" "1502" "164.1" "8.66" "4.70" "2" "" "nucleus" "other molecular function" "Pf01585" "23131" "ENSG00000186566" "GPATCH8" "B9EGP9; hsa:23131; O60300; Q8TB99; Q9UKJ3" "" "" "0" "0" "0.969" "1.023" "1.116" "1.048" "1.135" "1.042" "1.140" "1.120" "1.106" "40.2" "38.9" "41.1" "44.8" "42.1" "45.6" "41.9" "45.8" "45.0" "44.4" "" "" "" "" "" "" "" "" "" "" "32.3" "28.1" "32.6" "30.0" "29.1" "34.2" "29.3" "33.4" "45.0" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2389854899245022230" "False" "High" "IsMasterProtein" "A6NDU8" "RAB7A-interacting MON1-CCZ1 complex subunit 1 OS=Homo sapiens OX=9606 GN=RIMOC1 PE=1 SV=1" "0.000" "False" "4.933" "7" "2" "2" "2" "294" "33.6" "5.26" "5.72" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "" "Pf17716" "285636" "ENSG00000205765" "RIMOC1" "A2RRM9; A6NDU8; hsa:285636" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7987145187797725947" "False" "High" "IsMasterProtein" "Q9H6R0" "ATP-dependent RNA helicase DHX33 OS=Homo sapiens OX=9606 GN=DHX33 PE=1 SV=2" "0.000" "False" "4.930" "1" "1" "1" "1" "707" "78.8" "8.91" "3.52" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "56919" "ENSG00000005100" "DHX33" "B4DHF9; hsa:56919; Q4G149; Q5CZ73; Q9H5M9; Q9H6R0" "" "" "0" "0" "1.011" "1.074" "1.151" "1.233" "0.888" "1.212" "1.041" "0.900" "1.055" "103.1" "104.2" "110.7" "118.6" "127.1" "91.5" "124.9" "107.2" "92.7" "108.7" "" "" "" "" "" "" "" "" "" "" "82.8" "75.2" "87.9" "79.4" "87.9" "68.6" "87.4" "78.3" "92.7" "88.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8138947424293882527" "False" "High" "IsMasterProtein" "Q8WV60" "Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD2 PE=1 SV=3" "0.000" "False" "4.926" "2" "1" "1" "1" "388" "43.9" "9.23" "3.71" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion" "" "Pf10037" "79810" "ENSG00000049883" "PTCD2" "B7Z5D0; B7Z8L7; E9PFV7; hsa:79810; Q6IA65; Q8WV60; Q9H9R0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2498270271730422253" "False" "High" "IsMasterProtein" "Q6AI12" "Ankyrin repeat domain-containing protein 40 OS=Homo sapiens OX=9606 GN=ANKRD40 PE=1 SV=2" "0.000" "False" "4.920" "4" "2" "3" "2" "368" "41.1" "4.97" "7.44" "2" "" "" "" "Pf13637" "91369" "ENSG00000154945" "ANKRD40" "hsa:91369; Q6AI12; Q96E32" "" "" "0" "0" "0.991" "1.000" "1.021" "1.079" "0.941" "0.966" "0.874" "0.964" "0.977" "110.3" "109.3" "110.2" "112.6" "118.9" "103.8" "106.5" "96.3" "106.3" "107.7" "" "" "" "" "" "" "" "" "" "" "88.6" "78.8" "87.5" "75.4" "82.2" "77.9" "74.6" "70.4" "106.3" "87.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043676364934071043" "False" "High" "IsMasterProtein" "Q14254" "Flotillin-2 OS=Homo sapiens OX=9606 GN=FLOT2 PE=1 SV=2" "0.000" "False" "4.898" "3" "1" "2" "1" "428" "47.0" "5.25" "5.07" "1" "cell adhesion;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "" "Pf01145" "2319" "ENSG00000132589" "FLOT2" "hsa:2319; Q14254" "RHOB GTPase cycle; RND3 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RND1 GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5414288998537041680" "False" "High" "IsMasterProtein" "Q9UK53" "Inhibitor of growth protein 1 OS=Homo sapiens OX=9606 GN=ING1 PE=1 SV=2" "0.000" "False" "4.891" "7" "2" "3" "2" "422" "46.7" "9.06" "9.13" "2" "cell cycle OR cell proliferation;transport;other biological processes" "nucleus" "other molecular function" "Pf12998" "3621" "ENSG00000153487" "ING1" "hsa:3621; O00532; O43658; Q53ZR3; Q5T9G8; Q5T9G9; Q5T9H0; Q5T9H1; Q9H007; Q9HD98; Q9HD99; Q9NS83; Q9P0U6; Q9UBC6; Q9UIJ1; Q9UIJ2; Q9UIJ3; Q9UIJ4; Q9UK52; Q9UK53" "" "" "0" "0" "0.846" "0.890" "0.844" "0.799" "0.901" "0.794" "0.855" "0.928" "0.847" "380.3" "321.9" "338.6" "320.8" "303.8" "342.7" "302.1" "325.2" "352.8" "322.0" "" "" "" "" "" "" "" "" "" "" "305.5" "232.3" "269.0" "215.0" "210.1" "257.1" "211.5" "237.5" "352.8" "261.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627020223265262766" "False" "High" "IsMasterProtein" "Q8N0W3" "L-fucose kinase OS=Homo sapiens OX=9606 GN=FCSK PE=1 SV=2" "0.000" "False" "4.890" "2" "2" "2" "2" "1084" "117.5" "6.25" "5.50" "2" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf07959, Pf08544" "197258" "ENSG00000157353" "FCSK" "hsa:197258; Q5PSM3; Q5XKL6; Q6ZRA0; Q8N0W3; Q96MT9" "GDP-fucose biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3656224610955916872" "False" "High" "IsMasterProtein" "Q3KNV8" "Polycomb group RING finger protein 3 OS=Homo sapiens OX=9606 GN=PCGF3 PE=1 SV=1" "0.000" "False" "4.884" "6" "1" "1" "1" "242" "28.1" "8.22" "4.90" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf16207" "10336" "ENSG00000185619" "PCGF3" "D3DVN1; hsa:10336; O15262; Q3KNV8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5043724223572356605" "False" "High" "IsMasterProtein" "A6H8Y1" "Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3" "0.000" "False" "4.878" "1" "2" "2" "2" "2624" "293.7" "5.11" "5.63" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15963" "55814" "ENSG00000145734; ENSG00000273873" "BDP1" "A6H8Y1; hsa:55814; Q68DS6; Q68DY5; Q6MZL9; Q6PIM7; Q86W98; Q96LR8; Q9C0H4; Q9H197; Q9H1A1; Q9HAW1; Q9HAW2; Q9HCY0; Q9ULH9" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "" "4" "0" "0.963" "1.042" "1.024" "1.106" "1.049" "1.137" "0.956" "1.013" "1.099" "98.2" "94.5" "102.3" "100.6" "108.6" "103.0" "111.6" "93.8" "99.4" "107.9" "" "" "" "" "" "" "" "" "" "" "78.9" "68.2" "81.3" "67.4" "75.1" "77.3" "78.2" "68.5" "99.4" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2134905287649132421" "False" "High" "IsMasterProtein" "Q9Y312" "Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2" "0.000" "False" "4.870" "7" "2" "2" "2" "384" "43.4" "5.96" "3.38" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf05282, Pf20981" "25980" "ENSG00000131043" "AAR2" "E1P5S7; hsa:25980; Q9H4F9; Q9P1P3; Q9UFK9; Q9Y312" "" "Ciliary landscape" "1" "0" "0.956" "1.049" "1.057" "1.063" "1.071" "0.984" "0.995" "0.966" "0.963" "222.7" "213.0" "233.6" "235.4" "236.7" "238.6" "219.1" "221.6" "215.2" "214.4" "" "" "" "" "" "" "" "" "" "" "178.8" "153.7" "185.5" "157.7" "163.7" "179.0" "153.4" "161.8" "215.2" "174.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "698567651492244617" "False" "High" "IsMasterProtein" "Q96RL7" "Intermembrane lipid transfer protein VPS13A OS=Homo sapiens OX=9606 GN=VPS13A PE=1 SV=2" "0.000" "False" "4.860" "0" "1" "1" "1" "3174" "360.0" "6.33" "3.66" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "23230" "ENSG00000197969" "VPS13A" "hsa:23230; Q5JSX9; Q5JSY0; Q5VYR5; Q702P4; Q709D0; Q86YF8; Q96RL7; Q96S61; Q9H995; Q9Y2J1" "" "" "0" "0" "1.032" "1.067" "1.312" "1.245" "0.939" "1.166" "1.121" "0.960" "1.095" "54.9" "56.6" "58.6" "72.1" "68.3" "51.6" "64.0" "61.6" "52.7" "60.1" "" "" "" "" "" "" "" "" "" "" "44.1" "40.9" "46.6" "48.3" "47.3" "38.7" "44.8" "45.0" "52.7" "48.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7551679411334968012" "False" "High" "IsMasterProtein" "Q15649" "Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2" "0.000" "False" "4.858" "10" "2" "2" "2" "155" "17.6" "5.67" "6.46" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438, Pf21373" "9326" "ENSG00000273611; ENSG00000278574" "ZNHIT3" "A8K493; hsa:9326; K7EQP1; Q15649; Q8WVJ3" "" "17q12 copy number variation syndrome" "1" "0" "1.023" "1.084" "1.005" "0.903" "0.903" "0.929" "1.032" "1.000" "1.009" "173.8" "177.9" "188.4" "174.7" "156.9" "157.0" "161.4" "179.5" "173.8" "175.4" "" "" "" "" "" "" "" "" "" "" "139.6" "128.3" "149.7" "117.0" "108.5" "117.8" "113.0" "131.1" "173.8" "142.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8157720001899261977" "False" "High" "IsMasterProtein" "Q8NEM7" "Transcription factor SPT20 homolog OS=Homo sapiens OX=9606 GN=SUPT20H PE=1 SV=2" "0.000" "False" "4.851" "2" "1" "1" "1" "779" "85.7" "8.48" "3.72" "1" "other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12090" "55578" "ENSG00000102710" "SUPT20H" "E7ER46; hsa:55578; Q71RF3; Q8NEM7; Q9Y6A6" "HATs acetylate histones" "" "1" "0" "0.933" "0.962" "1.225" "1.022" "0.804" "0.994" "0.955" "0.980" "0.929" "32.5" "30.3" "31.2" "39.8" "33.2" "26.1" "32.3" "31.0" "31.8" "30.2" "" "" "" "" "" "" "" "" "" "" "26.1" "21.9" "24.8" "26.7" "23.0" "19.6" "22.6" "22.7" "31.8" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1939715462803938056" "False" "High" "IsMasterProtein" "O75691" "Small subunit processome component 20 homolog OS=Homo sapiens OX=9606 GN=UTP20 PE=1 SV=3" "0.000" "False" "4.848" "1" "2" "2" "2" "2785" "318.2" "7.39" "4.07" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf07539, Pf20416" "27340" "ENSG00000120800" "UTP20" "hsa:27340; O75691; Q9H3H4" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864201792584752389" "False" "High" "IsMasterProtein" "Q03188" "Centromere protein C OS=Homo sapiens OX=9606 GN=CENPC PE=1 SV=2" "0.000" "False" "4.845" "2" "1" "1" "1" "943" "106.8" "9.39" "3.21" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11699, Pf15620, Pf15622" "1060" "ENSG00000145241" "CENPC" "hsa:1060; Q03188; Q6PIR0; Q8IW27; Q9P0M5" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5936483343484820991" "False" "High" "IsMasterProtein" "Q8N5Y2" "MSL complex subunit 3 OS=Homo sapiens OX=9606 GN=MSL3 PE=1 SV=1" "0.000" "False" "4.839" "2" "1" "1" "1" "521" "59.8" "8.21" "3.92" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05712, Pf11717" "10943" "ENSG00000005302" "MSL3" "A6NCU2; A6NHW8; A8K165; B4DUV8; B7Z227; hsa:10943; Q8N5Y2; Q9UG70; Q9Y5Z8" "HATs acetylate histones" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4925331307854051957" "False" "High" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "0.000" "False" "4.837" "2" "1" "2" "1" "615" "70.7" "9.36" "4.02" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "Gastric cancer network 2; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "18" "0" "1.052" "1.144" "1.194" "1.158" "1.153" "0.898" "1.301" "1.230" "1.190" "255.3" "268.6" "292.0" "304.8" "295.6" "294.4" "229.3" "332.1" "314.1" "303.7" "" "" "" "" "" "" "" "" "" "" "205.1" "193.8" "232.0" "204.2" "204.5" "220.9" "160.6" "242.5" "314.1" "247.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4872124519361806264" "False" "High" "IsMasterProtein" "Q9H1P3" "Oxysterol-binding protein-related protein 2 OS=Homo sapiens OX=9606 GN=OSBPL2 PE=1 SV=1" "0.000" "False" "4.836" "3" "2" "2" "2" "480" "55.2" "6.35" "6.25" "2" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf01237" "9885" "ENSG00000130703" "OSBPL2" "A8K736; hsa:9885; Q6IBT0; Q9BZB1; Q9H1P3; Q9Y4B8" "Synthesis of bile acids and bile salts" "" "1" "0" "1.108" "1.244" "1.234" "1.145" "1.104" "1.039" "1.030" "1.086" "1.152" "90.2" "99.9" "112.2" "111.4" "103.3" "99.6" "93.7" "93.0" "98.0" "103.9" "" "" "" "" "" "" "" "" "" "" "72.5" "72.1" "89.1" "74.6" "71.5" "74.7" "65.6" "67.9" "98.0" "84.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8125473788962869493" "False" "High" "IsMasterProtein" "P09619" "Platelet-derived growth factor receptor beta OS=Homo sapiens OX=9606 GN=PDGFRB PE=1 SV=1" "0.000" "False" "4.832" "3" "2" "4" "1" "1106" "123.9" "4.98" "12.55" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00047, Pf07714, Pf13927" "5159" "ENSG00000113721" "PDGFRB" "B5A957; hsa:5159; P09619; Q8N5L4" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Downstream signal transduction" "Glioblastoma signaling pathways; PDGF pathway; Focal adhesion; Osteoblast signaling; Imatinib and chronic myeloid leukemia; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Ras signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; EGFR tyrosine kinase inhibitor resistance; Genes controlling nephrogenesis; Pleural mesothelioma; Regulation of actin cytoskeleton; Markers of kidney cell lineage; Macrophage-stimulating protein (MSP) signaling network map" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4179257016855703776" "False" "High" "IsMasterProtein" "Q53QV2" "Protein LBH OS=Homo sapiens OX=9606 GN=LBH PE=1 SV=1" "0.000" "False" "4.820" "15" "1" "1" "1" "105" "12.2" "4.41" "2.37" "1" "other biological processes" "nucleus;other cell component" "" "Pf15317" "81606" "ENSG00000213626" "LBH" "B2RBC2; hsa:81606; Q53QV2; Q9H0Q1" "" "" "0" "0" "0.859" "0.955" "0.925" "1.248" "0.930" "1.064" "1.100" "0.692" "1.067" "21.3" "18.3" "20.3" "19.7" "26.6" "19.8" "22.7" "23.4" "14.7" "22.7" "" "" "" "" "" "" "" "" "" "" "17.1" "13.2" "16.2" "13.2" "18.4" "14.9" "15.9" "17.1" "14.7" "18.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7679748802745987777" "False" "High" "IsMasterProtein" "Q9NUL7" "Probable ATP-dependent RNA helicase DDX28 OS=Homo sapiens OX=9606 GN=DDX28 PE=1 SV=2" "0.000" "False" "4.816" "2" "1" "1" "1" "540" "59.5" "10.42" "3.68" "1" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55794" "ENSG00000182810" "DDX28" "hsa:55794; Q9NUL7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6530118680274496318" "False" "High" "IsMasterProtein" "Q9UHB7" "AF4/FMR2 family member 4 OS=Homo sapiens OX=9606 GN=AFF4 PE=1 SV=1" "0.000" "False" "4.813" "2" "2" "2" "2" "1163" "127.4" "9.31" "4.76" "2" "stress response;other biological processes" "nucleus;other cell component" "" "Pf05110, Pf18875, Pf18876" "27125" "ENSG00000072364" "AFF4" "B2RP19; B7WPD2; hsa:27125; Q498B2; Q59FB3; Q6P592; Q8TDR1; Q9P0E4; Q9UHB7" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6890346438132187209" "False" "High" "IsMasterProtein" "Q14165" "Malectin OS=Homo sapiens OX=9606 GN=MLEC PE=1 SV=1" "0.000" "False" "4.812" "8" "2" "2" "2" "292" "32.2" "5.41" "2.79" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf11721" "9761" "ENSG00000110917" "MLEC" "hsa:9761; Q14165" "Neutrophil degranulation; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "2" "0" "1.171" "0.967" "0.959" "1.078" "1.014" "0.913" "0.939" "1.103" "1.035" "59.1" "69.2" "57.2" "56.7" "63.7" "60.0" "54.0" "55.5" "65.2" "61.2" "" "" "" "" "" "" "" "" "" "" "47.5" "49.9" "45.4" "38.0" "44.1" "45.0" "37.8" "40.5" "65.2" "49.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "186297121193818465" "False" "High" "IsMasterProtein" "Q5QJ74" "Tubulin-specific chaperone cofactor E-like protein OS=Homo sapiens OX=9606 GN=TBCEL PE=1 SV=2" "0.000" "False" "4.802" "3" "1" "1" "1" "424" "48.2" "5.38" "3.88" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf14560, Pf14580" "219899" "ENSG00000154114" "TBCEL" "hsa:219899; Q0VAN6; Q5QJ74" "" "" "0" "0" "1.062" "1.024" "0.984" "1.072" "1.057" "0.957" "1.082" "1.096" "1.277" "34.5" "36.7" "35.3" "34.0" "37.0" "36.5" "33.1" "37.4" "37.9" "44.1" "" "" "" "" "" "" "" "" "" "" "27.7" "26.5" "28.1" "22.8" "25.6" "27.4" "23.1" "27.3" "37.9" "35.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "877971590202694443" "False" "High" "IsMasterProtein" "Q6ZMZ3" "Nesprin-3 OS=Homo sapiens OX=9606 GN=SYNE3 PE=1 SV=2" "0.000" "False" "4.784" "1" "1" "1" "1" "975" "112.1" "6.23" "3.42" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00435, Pf10541" "161176" "ENSG00000176438" "SYNE3" "A6H8H3; Q6ZMZ3; Q86SX5; Q8N7G8" "" "Envelope proteins and their potential roles in EDMD physiopathology" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1943269179949256185" "False" "High" "IsMasterProtein" "Q96B70" "Leukocyte receptor cluster member 9 OS=Homo sapiens OX=9606 GN=LENG9 PE=1 SV=2" "0.000" "False" "4.782" "3" "1" "1" "1" "501" "53.1" "7.84" "3.35" "1" "" "" "other molecular function" "Pf00642, Pf04457, Pf10469" "" "ENSG00000273574; ENSG00000274495" "LENG9" "B2VAM3; Q96B70" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2793167296293415230" "False" "High" "IsMasterProtein" "Q96NL6" "Sodium channel and clathrin linker 1 OS=Homo sapiens OX=9606 GN=SCLT1 PE=1 SV=2" "0.000" "False" "4.780" "2" "2" "2" "1" "688" "80.9" "6.07" "5.21" "2" "cell organization and biogenesis;developmental processes" "other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "" "132320" "ENSG00000151466" "SCLT1" "A4QN04; hsa:132320; Q0VAH2; Q6P2M4; Q96NL6" "Anchoring of the basal body to the plasma membrane" "Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785970027012849018" "False" "High" "IsMasterProtein" "A0JLT2" "Mediator of RNA polymerase II transcription subunit 19 OS=Homo sapiens OX=9606 GN=MED19 PE=1 SV=2" "0.000" "False" "4.780" "7" "1" "1" "1" "244" "26.3" "9.82" "2.58" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10278" "219541" "ENSG00000156603" "MED19" "A0JLT2; hsa:219541; Q8IV02; Q8IZD1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635059186967103870" "False" "High" "IsMasterProtein" "Q96PC3" "AP-1 complex subunit sigma-3 OS=Homo sapiens OX=9606 GN=AP1S3 PE=1 SV=1" "0.000" "False" "4.769" "10" "2" "4" "1" "154" "18.3" "6.79" "10.97" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "130340" "ENSG00000152056" "AP1S3" "B4DQZ1; hsa:130340; Q8WTY1; Q96DD1; Q96PC3" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "0" "1.134" "0.830" "1.825" "1.311" "0.790" "1.781" "1.088" "0.926" "1.108" "115.1" "130.5" "95.6" "210.1" "151.0" "90.9" "205.1" "125.2" "106.6" "127.5" "" "" "" "" "" "" "" "" "" "" "92.5" "94.2" "75.9" "140.8" "104.4" "68.2" "143.6" "91.4" "106.6" "103.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5141093317977798978" "False" "High" "IsMasterProtein" "Q9H6S1" "5-azacytidine-induced protein 2 OS=Homo sapiens OX=9606 GN=AZI2 PE=1 SV=1" "0.000" "False" "4.757" "3" "1" "1" "1" "392" "44.9" "6.60" "3.25" "1" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "other cell component" "" "Pf12845" "64343" "ENSG00000163512" "AZI2" "A8K3M2; C9JB40; H7BXU6; hsa:64343; Q86W99; Q9BQF1; Q9H6S1" "" "Novel intracellular components of RIG-I-like receptor pathway" "1" "0" "1.017" "0.976" "1.170" "1.070" "1.122" "0.995" "0.978" "1.122" "0.969" "105.0" "106.7" "102.4" "122.8" "112.3" "117.7" "104.5" "102.7" "117.7" "101.7" "" "" "" "" "" "" "" "" "" "" "84.3" "77.0" "81.3" "82.3" "77.6" "88.3" "73.1" "75.0" "117.7" "82.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4254593612476960216" "False" "High" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "0.000" "False" "4.755" "3" "1" "2" "1" "278" "29.5" "8.56" "3.58" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "Peroxisomal protein import; RA biosynthesis pathway" "" "2" "0" "0.957" "0.948" "1.115" "0.995" "0.889" "1.062" "1.005" "0.999" "0.995" "115.6" "110.6" "109.6" "128.8" "115.0" "102.8" "122.8" "116.2" "115.4" "115.0" "" "" "" "" "" "" "" "" "" "" "92.8" "79.8" "87.0" "86.3" "79.5" "77.1" "86.0" "84.9" "115.4" "93.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1550245044930584374" "False" "High" "IsMasterProtein" "O60583" "Cyclin-T2 OS=Homo sapiens OX=9606 GN=CCNT2 PE=1 SV=2" "0.000" "False" "4.746" "2" "2" "2" "2" "730" "81.0" "8.92" "4.98" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "905" "ENSG00000082258" "CCNT2" "A8KA48; D3DP73; D3DP74; hsa:905; O60582; O60583; Q29R66; Q53SR4; Q5I1Y0" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "Male infertility" "10" "0" "1.111" "0.980" "1.030" "1.195" "1.038" "1.108" "1.101" "1.185" "1.158" "111.7" "124.1" "109.4" "115.0" "133.4" "115.9" "123.7" "123.0" "132.4" "129.4" "" "" "" "" "" "" "" "" "" "" "89.7" "89.6" "86.9" "77.1" "92.3" "87.0" "86.6" "89.8" "132.4" "105.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7269919126570467546" "False" "High" "IsMasterProtein" "Q16514" "Transcription initiation factor TFIID subunit 12 OS=Homo sapiens OX=9606 GN=TAF12 PE=1 SV=1" "0.000" "False" "4.746" "11" "2" "3" "2" "161" "17.9" "7.99" "8.89" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03847" "6883" "ENSG00000120656" "TAF12" "D3DPM5; hsa:6883; Q15775; Q16514; Q5T077" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation; HATs acetylate histones" "Eukaryotic transcription initiation" "11" "0" "1.088" "1.095" "1.122" "1.034" "0.941" "0.966" "1.002" "1.069" "1.107" "164.6" "179.0" "180.2" "184.6" "170.2" "154.8" "159.0" "164.9" "175.9" "182.2" "" "" "" "" "" "" "" "" "" "" "132.2" "129.2" "143.2" "123.7" "117.7" "116.2" "111.3" "120.4" "175.9" "148.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159074218320120217" "False" "High" "IsMasterProtein" "A8MT69" "Centromere protein X OS=Homo sapiens OX=9606 GN=CENPX PE=1 SV=1" "0.000" "False" "4.745" "11" "1" "1" "1" "81" "9.0" "5.90" "3.77" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09415" "201254" "ENSG00000169689" "CENPX" "A8MT69; hsa:201254; O00281; O00282; Q96DD4; Q96F51" "Fanconi Anemia Pathway; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "DNA repair pathways, full network" "4" "0" "1.131" "0.982" "1.287" "1.221" "1.232" "1.490" "1.457" "1.206" "1.125" "109.6" "124.0" "107.6" "141.0" "133.8" "135.0" "163.2" "159.7" "132.1" "123.2" "" "" "" "" "" "" "" "" "" "" "88.0" "89.4" "85.5" "94.5" "92.6" "101.3" "114.3" "116.6" "132.1" "100.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5948968873107767140" "False" "High" "IsMasterProtein" "Q9P246" "Stromal interaction molecule 2 OS=Homo sapiens OX=9606 GN=STIM2 PE=1 SV=2" "0.000" "False" "4.730" "1" "1" "1" "1" "746" "83.9" "6.76" "3.71" "1" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf07647, Pf16533" "57620" "ENSG00000109689" "STIM2" "A6H8L7; B7ZVY0; hsa:57620; Q96BF1; Q9BQH2; Q9H8R1; Q9P246" "" "Calcium regulation in cardiac cells" "1" "0" "1.075" "1.074" "1.165" "1.299" "1.234" "1.084" "1.175" "1.329" "1.412" "97.6" "105.0" "104.9" "113.8" "126.8" "120.5" "105.9" "114.7" "129.7" "137.8" "" "" "" "" "" "" "" "" "" "" "78.4" "75.8" "83.3" "76.2" "87.7" "90.4" "74.1" "83.8" "129.7" "112.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-130690685770980429" "False" "High" "IsMasterProtein" "Q9NWS6" "Protein FAM118A OS=Homo sapiens OX=9606 GN=FAM118A PE=1 SV=2" "0.000" "False" "4.725" "5" "1" "1" "1" "357" "40.2" "6.09" "3.48" "1" "" "other membranes" "other molecular function" "Pf13289" "55007" "ENSG00000100376" "FAM118A" "B3KWG4; B4DY02; hsa:55007; Q5TII5; Q96CY3; Q9NWS6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "590276225790957445" "False" "High" "IsMasterProtein" "O14921" "Regulator of G-protein signaling 13 OS=Homo sapiens OX=9606 GN=RGS13 PE=1 SV=1" "0.000" "False" "4.717" "6" "1" "1" "1" "159" "19.1" "8.88" "3.67" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00615" "6003" "ENSG00000127074" "RGS13" "hsa:6003; O14921; Q6PGR2; Q8TD63; Q9BX45" "G alpha (q) signalling events; G alpha (i) signalling events" "" "2" "0" "1.114" "1.052" "1.063" "1.012" "1.070" "0.942" "0.843" "0.939" "0.954" "149.5" "166.5" "157.4" "158.9" "151.3" "159.9" "140.8" "126.0" "140.4" "142.6" "" "" "" "" "" "" "" "" "" "" "120.1" "120.1" "125.0" "106.5" "104.6" "120.0" "98.6" "92.0" "140.4" "116.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8526861795692287608" "False" "High" "IsMasterProtein" "Q6PK04" "Coiled-coil domain-containing protein 137 OS=Homo sapiens OX=9606 GN=CCDC137 PE=1 SV=1" "0.000" "False" "4.715" "3" "1" "1" "1" "289" "33.2" "10.93" "4.32" "1" "" "nucleus;other cell component" "" "" "339230" "ENSG00000185298" "CCDC137" "hsa:339230; Q6PK04" "" "" "0" "0" "1.005" "1.051" "1.136" "1.156" "1.056" "1.227" "1.091" "1.045" "1.076" "131.2" "131.9" "137.9" "149.1" "151.7" "138.6" "161.0" "143.1" "137.1" "141.2" "" "" "" "" "" "" "" "" "" "" "105.4" "95.1" "109.5" "99.9" "104.9" "104.0" "112.7" "104.5" "137.1" "114.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "745501104914831444" "False" "High" "IsMasterProtein" "P53805" "Calcipressin-1 OS=Homo sapiens OX=9606 GN=RCAN1 PE=1 SV=4" "0.000" "False" "4.711" "5" "1" "1" "1" "252" "28.1" "5.21" "4.23" "1" "stress response;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04847" "1827" "ENSG00000159200" "RCAN1" "D3DSF9; hsa:1827; O00582; O00583; P53805; Q53XT0; Q6IBC6; Q7Z555; Q96R03; Q9BU69; Q9UF15; Q9UME4" "" "MicroRNAs in cardiomyocyte hypertrophy; VEGFA-VEGFR2 signaling" "2" "0" "1.090" "1.008" "1.138" "1.163" "0.929" "0.998" "1.038" "0.943" "1.012" "90.2" "98.2" "90.8" "102.6" "104.9" "83.8" "90.0" "93.5" "85.0" "91.2" "" "" "" "" "" "" "" "" "" "" "72.4" "70.9" "72.2" "68.7" "72.5" "62.9" "63.0" "68.3" "85.0" "74.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1537630137721928118" "False" "High" "IsMasterProtein" "Q8IU60" "m7GpppN-mRNA hydrolase OS=Homo sapiens OX=9606 GN=DCP2 PE=1 SV=3" "0.000" "False" "4.706" "4" "2" "2" "2" "420" "48.4" "8.00" "5.79" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293, Pf05026" "167227" "ENSG00000172795" "DCP2" "C9J778; hsa:167227; Q6P2D4; Q7Z5W5; Q8IU60; Q8NBG5" "mRNA decay by 5' to 3' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "" "5" "0" "1.134" "1.260" "1.202" "1.239" "1.205" "1.159" "1.119" "1.286" "1.156" "120.0" "136.0" "151.1" "144.2" "148.6" "144.6" "139.1" "134.2" "154.2" "138.7" "" "" "" "" "" "" "" "" "" "" "96.4" "98.1" "120.0" "96.6" "102.8" "108.5" "97.4" "98.0" "154.2" "112.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1883044830996479465" "False" "High" "IsMasterProtein" "O15021" "Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=MAST4 PE=1 SV=4" "0.000" "False" "4.706" "1" "2" "3" "1" "2623" "283.9" "8.62" "7.55" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf08926, Pf17820" "375449" "ENSG00000069020" "MAST4" "A6NL49; B5ME48; E7EWQ5; hsa:375449; J3QT34; O15021; Q05EE6; Q6ZN07; Q8N4X4; Q96LY3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3784875960281055954" "False" "High" "IsMasterProtein" "O00311" "Cell division cycle 7-related protein kinase OS=Homo sapiens OX=9606 GN=CDC7 PE=1 SV=1" "0.000" "False" "4.703" "3" "2" "2" "2" "574" "63.8" "8.73" "5.40" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8317" "ENSG00000097046" "CDC7" "D3DT31; hsa:8317; O00311; O00558; Q5T5U5" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Transcriptional Regulation by E2F6" "Cell cycle; Retinoblastoma gene in cancer; DNA replication" "6" "0" "0.933" "0.910" "1.018" "1.081" "0.976" "1.141" "1.301" "1.216" "1.079" "236.3" "220.6" "215.1" "240.5" "255.4" "230.6" "269.6" "307.3" "287.3" "255.0" "" "" "" "" "" "" "" "" "" "" "189.8" "159.2" "170.8" "161.2" "176.6" "173.0" "188.8" "224.5" "287.3" "207.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3289873417268458662" "False" "High" "IsMasterProtein" "Q9NX40" "OCIA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OCIAD1 PE=1 SV=1" "0.000" "False" "4.702" "8" "2" "2" "2" "245" "27.6" "7.49" "3.48" "2" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "54940" "ENSG00000109180" "OCIAD1" "C9K030; G8JLN7; hsa:54940; Q9BZE8; Q9NX40" "" "" "0" "0" "0.990" "1.028" "1.213" "1.145" "1.096" "1.101" "1.024" "1.075" "1.097" "135.1" "133.8" "138.9" "163.9" "154.6" "148.1" "148.7" "138.3" "145.2" "148.1" "" "" "" "" "" "" "" "" "" "" "108.5" "96.5" "110.3" "109.8" "106.9" "111.1" "104.1" "101.0" "145.2" "120.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "662430967221413337" "False" "High" "IsMasterProtein" "Q8N264" "Rho GTPase-activating protein 24 OS=Homo sapiens OX=9606 GN=ARHGAP24 PE=1 SV=2" "0.000" "False" "4.693" "1" "1" "1" "1" "748" "84.2" "6.67" "4.24" "1" "stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity" "Pf00169, Pf00620" "83478" "ENSG00000138639" "ARHGAP24" "hsa:83478; Q4KMG1; Q6ZNV3; Q86TI5; Q86WE4; Q8N264; Q9H0T6" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "Nephrotic syndrome" "4" "0" "1.045" "0.896" "0.991" "1.089" "0.993" "1.039" "1.034" "0.894" "1.035" "169.5" "177.0" "151.9" "168.0" "184.6" "168.2" "176.1" "175.2" "151.6" "175.4" "" "" "" "" "" "" "" "" "" "" "136.1" "127.7" "120.6" "112.5" "127.7" "126.2" "123.3" "128.0" "151.6" "142.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5414866276259702487" "False" "High" "IsMasterProtein" "Cont_P81644" "Apolipoprotein A-II OS=Bos taurus OX=9913 GN=APOA2 PE=1 SV=2" "0.000" "True" "4.674" "9" "1" "1" "1" "100" "11.2" "8.10" "3.90" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf04711" "109578286; 505394" "ENSBIXG00000027093; ENSBIXG00005019464; ENSBTAG00000009212" "APOA2" "A0A4W2I5U3; A0A6P5E192; biu:109578286; bta:505394; P81644; Q2NKV9" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; Retinoid metabolism and transport" "Statin pathway" "6" "0" "1.080" "0.978" "1.120" "0.889" "1.014" "1.439" "1.071" "1.062" "1.124" "252.3" "272.6" "246.8" "282.6" "224.3" "256.0" "363.1" "270.4" "268.0" "283.6" "" "" "" "" "" "" "" "" "" "" "202.7" "196.7" "196.0" "189.4" "155.1" "192.0" "254.2" "197.4" "268.0" "230.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8414928618058390258" "False" "High" "IsMasterProtein" "Q8N9N2" "Activating signal cointegrator 1 complex subunit 1 OS=Homo sapiens OX=9606 GN=ASCC1 PE=1 SV=1" "0.000" "False" "4.668" "2" "1" "1" "1" "400" "45.5" "5.54" "4.63" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf10469" "51008" "ENSG00000138303" "ASCC1" "hsa:51008; Q5SW06; Q5SW07; Q8N9N2; Q96EI8; Q9Y307" "ALKBH3 mediated reversal of alkylation damage" "Neuroinflammation" "2" "0" "1.077" "1.063" "0.974" "1.061" "1.130" "0.888" "0.993" "1.069" "1.071" "281.1" "302.7" "298.7" "273.8" "298.3" "317.7" "249.6" "279.1" "300.4" "301.2" "" "" "" "" "" "" "" "" "" "" "225.8" "218.4" "237.3" "183.5" "206.3" "238.4" "174.8" "203.8" "300.4" "244.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094708502747754814" "False" "High" "IsMasterProtein" "P61313" "Large ribosomal subunit protein eL15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "0.000" "False" "4.648" "4" "1" "2" "1" "204" "24.1" "11.62" "7.03" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.046" "1.217" "1.522" "1.101" "1.151" "1.323" "0.926" "1.209" "1.172" "355.6" "371.9" "432.8" "541.2" "391.6" "409.2" "470.5" "329.4" "429.8" "416.8" "" "" "" "" "" "" "" "" "" "" "285.6" "268.4" "343.8" "362.6" "270.8" "307.0" "329.4" "240.6" "429.8" "338.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3373935659803620703" "False" "High" "IsMasterProtein" "Q9UKY1" "Zinc fingers and homeoboxes protein 1 OS=Homo sapiens OX=9606 GN=ZHX1 PE=1 SV=1" "0.000" "False" "4.644" "1" "1" "2" "1" "873" "98.0" "6.05" "5.99" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf11569, Pf18387" "11244" "ENSG00000165156" "ZHX1" "hsa:11244; Q8IWD8; Q9UKY1" "" "" "0" "0" "1.018" "1.002" "1.213" "1.057" "1.002" "1.030" "1.040" "1.035" "1.017" "150.6" "153.2" "150.9" "182.6" "159.1" "150.8" "155.1" "156.5" "155.8" "153.1" "" "" "" "" "" "" "" "" "" "" "120.9" "110.6" "119.9" "122.3" "110.0" "113.2" "108.6" "114.3" "155.8" "124.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6752970450865449167" "False" "High" "IsMasterProtein" "Q16795" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFA9 PE=1 SV=2" "0.000" "False" "4.624" "3" "1" "1" "1" "377" "42.5" "9.80" "3.04" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01370" "4704" "ENSG00000139180" "NDUFA9" "hsa:4704; Q14076; Q16795; Q2NKX0" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "0.944" "0.865" "1.074" "1.002" "1.036" "0.948" "1.036" "1.078" "0.973" "75.8" "71.6" "65.5" "81.4" "75.9" "78.5" "71.8" "78.5" "81.7" "73.7" "" "" "" "" "" "" "" "" "" "" "60.9" "51.6" "52.1" "54.5" "52.5" "58.9" "50.3" "57.3" "81.7" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1367538517643276436" "False" "High" "IsMasterProtein" "Q13724" "Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5" "0.000" "False" "4.617" "1" "1" "1" "1" "837" "91.9" "8.90" "3.74" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf03200, Pf16923" "7841" "ENSG00000115275" "MOGS" "A8K938; F5H6D0; hsa:7841; Q13724; Q17RN9; Q8TCT5" "Maturation of spike protein; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Maturation of spike protein; Defective MOGS causes CDG-2b" "N-glycan biosynthesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334840059881177708" "False" "High" "IsMasterProtein" "Q16864" "V-type proton ATPase subunit F OS=Homo sapiens OX=9606 GN=ATP6V1F PE=1 SV=2" "0.000" "False" "4.601" "7" "1" "2" "1" "119" "13.4" "5.52" "3.01" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity" "Pf01990" "9296" "ENSG00000128524" "ATP6V1F" "C9J2K4; hsa:9296; Q16864; Q6IBA8" "ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "1.020" "0.987" "0.941" "0.996" "1.222" "0.960" "1.002" "1.281" "1.111" "155.0" "158.1" "152.9" "145.9" "154.4" "189.4" "148.9" "155.3" "198.5" "172.1" "" "" "" "" "" "" "" "" "" "" "124.5" "114.1" "121.5" "97.8" "106.8" "142.1" "104.2" "113.4" "198.5" "140.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5299456138050834551" "False" "High" "IsMasterProtein" "O00115" "Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2" "0.000" "False" "4.592" "3" "1" "1" "1" "360" "39.6" "8.05" "4.01" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf03265" "1777" "ENSG00000105612" "DNASE2" "B2RD06; B7Z4K6; hsa:1777; O00115; O43910" "Lysosome Vesicle Biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7316377890206410152" "False" "High" "IsMasterProtein" "Q00536" "Cyclin-dependent kinase 16 OS=Homo sapiens OX=9606 GN=CDK16 PE=1 SV=1" "0.000" "False" "4.591" "3" "2" "5" "1" "496" "55.7" "7.62" "12.42" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5127" "ENSG00000102225" "CDK16" "A8K280; B7Z7C8; hsa:5127; J3KN74; J3KQP7; Q00536" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8770994812284834829" "False" "High" "IsMasterProtein" "Q9UKT7" "F-box/LRR-repeat protein 3 OS=Homo sapiens OX=9606 GN=FBXL3 PE=1 SV=1" "0.000" "False" "4.590" "4" "2" "2" "2" "428" "48.7" "6.89" "5.34" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12937" "26224" "ENSG00000005812" "FBXL3" "B2RB04; hsa:26224; Q9P122; Q9UKT7" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Circadian Clock; Association of TriC/CCT with target proteins during biosynthesis" "" "4" "0" "1.115" "0.954" "1.038" "1.006" "0.954" "0.961" "1.067" "1.063" "1.126" "157.1" "175.2" "149.9" "163.1" "158.1" "149.9" "151.1" "167.7" "167.0" "177.0" "" "" "" "" "" "" "" "" "" "" "126.2" "126.4" "119.1" "109.3" "109.3" "112.5" "105.8" "122.4" "167.0" "143.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1678245631285885467" "False" "High" "IsMasterProtein" "Q2V2M9" "FH1/FH2 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FHOD3 PE=1 SV=2" "0.000" "False" "4.589" "1" "1" "1" "1" "1422" "158.5" "5.99" "2.37" "1" "cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf02181, Pf18382" "80206" "ENSG00000134775" "FHOD3" "A8MQT4; E5F5Q0; hsa:80206; Q2V2M9; Q642I2; Q6ZRQ7; Q86TF9; Q8N3A5; Q9C0G8; Q9H604; Q9H6G7" "" "" "0" "0" "1.461" "0.890" "1.777" "1.363" "1.209" "1.214" "0.908" "1.133" "1.133" "137.6" "201.1" "122.5" "244.6" "187.6" "166.4" "167.1" "125.0" "156.0" "156.0" "" "" "" "" "" "" "" "" "" "" "110.6" "145.1" "97.3" "163.9" "129.7" "124.8" "117.0" "91.3" "156.0" "126.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1046080233580331926" "False" "High" "IsMasterProtein" "Q8TEK3" "Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens OX=9606 GN=DOT1L PE=1 SV=3" "0.000" "False" "4.581" "2" "2" "2" "2" "1537" "164.8" "9.19" "2.07" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08123" "84444" "ENSG00000104885" "DOT1L" "hsa:84444; O60379; Q8TEK3; Q96JL1" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-794247632168197847" "False" "High" "IsMasterProtein" "Q8NI37" "Protein phosphatase PTC7 homolog OS=Homo sapiens OX=9606 GN=PPTC7 PE=1 SV=1" "0.000" "False" "4.577" "4" "1" "1" "1" "304" "32.6" "5.19" "3.64" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf07228" "160760" "ENSG00000196850" "PPTC7" "B3KWC5; hsa:160760; Q68DZ7; Q6UY82; Q8NI37" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2112177249442746941" "False" "High" "IsMasterProtein" "Q8N5Z5" "BTB/POZ domain-containing protein KCTD17 OS=Homo sapiens OX=9606 GN=KCTD17 PE=1 SV=4" "0.000" "False" "4.576" "10" "2" "2" "1" "314" "34.9" "4.82" "3.58" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf02214" "79734" "ENSG00000100379" "KCTD17" "B0QYA9; B0QYB0; hsa:79734; O95517; Q8N5Z5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8329902597412157938" "False" "High" "IsMasterProtein" "Q15048" "Leucine-rich repeat-containing protein 14 OS=Homo sapiens OX=9606 GN=LRRC14 PE=1 SV=1" "0.000" "False" "4.564" "2" "1" "1" "1" "493" "54.5" "6.90" "3.59" "1" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf13516" "9684" "ENSG00000160959" "LRRC14" "A8K0A8; D3DWM8; hsa:9684; Q15048" "Regulation of NF-kappa B signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2944627294603634095" "False" "High" "IsMasterProtein" "Q14191" "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN OS=Homo sapiens OX=9606 GN=WRN PE=1 SV=2" "0.000" "False" "4.553" "1" "1" "1" "1" "1432" "162.4" "6.34" "3.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf01612, Pf09382, Pf14493, Pf16124" "7486" "ENSG00000165392" "WRN" "A1KYY9; hsa:7486; Q14191" "SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Regulation of TP53 Activity through Phosphorylation; Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Removal of the Flap Intermediate from the C-strand" "Non-homologous end joining; DNA repair pathways, full network; Progeria-associated lipodystrophy; Primary ovarian insufficiency" "21" "0" "1.004" "1.149" "1.147" "1.042" "1.153" "1.135" "1.101" "1.059" "1.140" "182.7" "183.4" "210.0" "209.6" "190.3" "210.7" "207.3" "201.2" "193.5" "208.3" "" "" "" "" "" "" "" "" "" "" "146.7" "132.3" "166.8" "140.4" "131.6" "158.1" "145.2" "146.9" "193.5" "169.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901599109911946457" "False" "High" "IsMasterProtein" "Q9Y5A6" "Zinc finger and SCAN domain-containing protein 21 OS=Homo sapiens OX=9606 GN=ZSCAN21 PE=1 SV=2" "0.000" "False" "4.544" "3" "1" "1" "1" "473" "53.6" "7.72" "3.40" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7589" "ENSG00000166529" "ZSCAN21" "A4D2A6; D6W5T9; hsa:7589; Q9H0B5; Q9Y5A6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2021793089049175464" "False" "High" "IsMasterProtein" "Q9HD67" "Unconventional myosin-X OS=Homo sapiens OX=9606 GN=MYO10 PE=1 SV=3" "0.000" "False" "4.535" "1" "2" "2" "2" "2058" "237.2" "6.21" "6.14" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00169, Pf00373, Pf00612, Pf00784, Pf00788, Pf16735, Pf18597" "4651" "ENSG00000145555" "MYO10" "A7E2D1; hsa:4651; O94893; Q8IVX5; Q9HD67; Q9NYM7; Q9P110; Q9P111; Q9UHF6" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Netrin-1 signaling" "" "3" "0" "1.071" "1.168" "1.221" "1.098" "1.061" "1.153" "0.985" "1.040" "1.091" "120.3" "128.8" "140.4" "146.8" "132.0" "127.6" "138.7" "118.5" "125.1" "131.2" "" "" "" "" "" "" "" "" "" "" "96.6" "92.9" "111.5" "98.4" "91.3" "95.7" "97.1" "86.5" "125.1" "106.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5519015022968038253" "False" "High" "IsMasterProtein" "Q86X10" "Ral GTPase-activating protein subunit beta OS=Homo sapiens OX=9606 GN=RALGAPB PE=1 SV=1" "0.000" "False" "4.530" "1" "2" "2" "2" "1494" "166.7" "6.79" "5.90" "2" "other biological processes" "" "enzyme regulator activity;other molecular function" "Pf20412" "57148" "ENSG00000170471" "RALGAPB" "A2A2E8; A2A2E9; hsa:57148; Q5TG31; Q86X10; Q8N3D1; Q8WWC0; Q9H3X8; Q9UJR1; Q9ULK1; Q9Y3G9" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "1.367" "1.149" "1.274" "1.303" "1.276" "1.300" "1.132" "1.212" "1.261" "65.4" "89.3" "75.1" "83.2" "85.2" "83.4" "85.0" "74.0" "79.2" "82.4" "" "" "" "" "" "" "" "" "" "" "52.5" "64.4" "59.7" "55.8" "58.9" "62.6" "59.5" "54.0" "79.2" "67.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8105981666538771075" "False" "High" "IsMasterProtein" "P80297" "Metallothionein-1X OS=Homo sapiens OX=9606 GN=MT1X PE=1 SV=1" "0.000" "False" "4.527" "13" "1" "2" "1" "61" "6.1" "7.96" "7.06" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "4501" "ENSG00000187193" "MT1X" "A8MUC7; hsa:4501; P80297" "Metallothioneins bind metals" "Copper homeostasis; Zinc homeostasis; Oxidative stress response" "4" "0" "1.018" "0.875" "0.629" "0.873" "1.076" "1.367" "1.048" "1.009" "0.891" "129.7" "132.1" "113.5" "81.5" "113.2" "139.5" "177.4" "135.9" "130.8" "115.6" "" "" "" "" "" "" "" "" "" "" "104.2" "95.3" "90.2" "54.6" "78.3" "104.7" "124.2" "99.3" "130.8" "94.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3007034205902659738" "False" "High" "IsMasterProtein" "Q63HM1" "Kynurenine formamidase OS=Homo sapiens OX=9606 GN=AFMID PE=1 SV=2" "0.000" "False" "4.525" "3" "1" "1" "1" "303" "34.0" "5.91" "1.90" "1" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07859" "125061" "ENSG00000183077" "AFMID" "A2RUB3; hsa:125061; Q63HM1" "Tryptophan catabolism" "NAD biosynthesis II (from tryptophan); Tryptophan metabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5970229024696725622" "False" "High" "IsMasterProtein" "O96020" "G1/S-specific cyclin-E2 OS=Homo sapiens OX=9606 GN=CCNE2 PE=1 SV=1" "0.000" "False" "4.510" "3" "1" "1" "1" "404" "46.7" "7.83" "3.95" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "9134" "ENSG00000175305" "CCNE2" "hsa:9134; O95439; O96020" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response" "miRNA regulation of DNA damage response; Cell cycle; Parkinson's disease pathway; Retinoblastoma gene in cancer; PI3K-Akt signaling pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; NF1 copy number variation syndrome ; DNA damage response" "22" "0" "1.333" "1.212" "1.104" "1.160" "1.080" "1.834" "2.403" "2.041" "1.573" "26.6" "35.5" "32.2" "29.3" "30.9" "28.7" "48.8" "63.9" "54.3" "41.8" "" "" "" "" "" "" "" "" "" "" "21.4" "25.6" "25.6" "19.7" "21.3" "21.5" "34.1" "46.7" "54.3" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2217826250867961619" "False" "High" "IsMasterProtein" "Q6P4F2" "Ferredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=FDX2 PE=1 SV=3" "0.000" "False" "4.507" "6" "1" "2" "1" "183" "19.5" "5.38" "8.53" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00111" "112812" "ENSG00000267673" "FDX2" "B7Z6L7; Q6P4F2; Q8N8B8" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8284852689861497980" "False" "High" "IsMasterProtein" "Q5VV52" "Zinc finger protein 691 OS=Homo sapiens OX=9606 GN=ZNF691 PE=1 SV=2" "0.000" "False" "4.504" "5" "1" "1" "1" "315" "35.8" "7.80" "2.88" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465" "51058" "ENSG00000164011" "ZNF691" "A8MXP6; B4DJR7; hsa:51058; O95878; Q5VV52; Q9NWE8" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8993746763041335004" "False" "High" "IsMasterProtein" "Q69YQ0" "Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=3" "0.000" "False" "4.501" "1" "1" "2" "1" "1117" "124.5" "5.76" "3.80" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00307" "23384" "ENSG00000100014" "SPECC1L" "B7Z758; F5H1H6; hsa:23384; O15081; Q69YQ0" "" "" "0" "0" "0.998" "0.886" "1.263" "1.148" "1.164" "1.239" "1.166" "1.102" "1.139" "89.0" "88.8" "78.8" "112.4" "102.2" "103.6" "110.3" "103.8" "98.1" "101.4" "" "" "" "" "" "" "" "" "" "" "71.5" "64.1" "62.6" "75.3" "70.7" "77.7" "77.2" "75.8" "98.1" "82.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2077357553309592028" "False" "High" "IsMasterProtein" "P51587" "Breast cancer type 2 susceptibility protein OS=Homo sapiens OX=9606 GN=BRCA2 PE=1 SV=4" "0.000" "False" "4.496" "1" "2" "2" "2" "3418" "384.0" "6.71" "2.96" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00634, Pf09103, Pf09104, Pf09121, Pf09169, Pf21318" "675" "ENSG00000139618" "BRCA2" "hsa:675; O00183; O15008; P51587; Q13879; Q5TBJ7" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; Impaired BRCA2 binding to RAD51; HDR through MMEJ (alt-NHEJ); Impaired BRCA2 translocation to the nucleus; Impaired BRCA2 binding to SEM1 (DSS1)" "Homologous recombination; Glioblastoma signaling pathways; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "21" "0" "1.089" "0.915" "0.971" "0.862" "1.027" "1.026" "0.963" "0.804" "1.001" "216.3" "235.5" "197.9" "210.1" "186.4" "222.1" "222.0" "208.4" "173.9" "216.5" "" "" "" "" "" "" "" "" "" "" "173.7" "169.9" "157.2" "140.8" "128.9" "166.6" "155.4" "152.2" "173.9" "176.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4761447816173578435" "False" "High" "IsMasterProtein" "Q9BQA5" "Histone H4 transcription factor OS=Homo sapiens OX=9606 GN=HINFP PE=1 SV=2" "0.000" "False" "4.496" "2" "1" "1" "1" "517" "59.6" "6.19" "4.07" "1" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "25988" "ENSG00000172273" "HINFP" "B3KPH6; B4DWB4; E9PQF4; hsa:25988; Q96E65; Q9BQA5; Q9Y4M7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2164411391658513183" "False" "High" "IsMasterProtein" "O94887" "FERM, ARHGEF and pleckstrin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FARP2 PE=1 SV=3" "0.000" "False" "4.492" "2" "2" "2" "2" "1054" "119.8" "8.79" "4.80" "2" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf00169, Pf00373, Pf00621, Pf08736, Pf09379, Pf09380" "9855" "ENSG00000006607" "FARP2" "B7Z6J8; F5GZ84; hsa:9855; O94887; Q53QM5; Q8WU27; Q9UFE7" "RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" "2q37 copy number variation syndrome; TAR syndrome" "4" "0" "1.106" "1.063" "1.076" "1.044" "1.032" "1.115" "1.077" "1.056" "1.049" "475.7" "526.3" "505.9" "511.8" "496.6" "490.8" "530.6" "512.5" "502.3" "498.9" "" "" "" "" "" "" "" "" "" "" "382.1" "379.7" "401.9" "342.9" "343.5" "368.2" "371.5" "374.3" "502.3" "405.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5882151393090730100" "False" "High" "IsMasterProtein" "Q8TA86" "Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2" "0.000" "False" "4.491" "4" "1" "1" "1" "221" "26.1" "9.79" "3.39" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6100" "ENSG00000164610" "RP9" "hsa:6100; Q8TA86" "" "" "0" "0" "0.995" "1.007" "1.065" "1.098" "0.906" "1.063" "1.055" "1.038" "0.978" "115.0" "114.4" "115.8" "122.5" "126.3" "104.2" "122.2" "121.4" "119.3" "112.5" "" "" "" "" "" "" "" "" "" "" "92.4" "82.6" "92.0" "82.1" "87.3" "78.2" "85.6" "88.6" "119.3" "91.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5292178720609404720" "False" "High" "IsMasterProtein" "Q16667" "Cyclin-dependent kinase inhibitor 3 OS=Homo sapiens OX=9606 GN=CDKN3 PE=1 SV=1" "0.000" "False" "4.480" "4" "1" "1" "1" "212" "23.8" "6.40" "3.86" "1" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05706" "1033" "ENSG00000100526" "CDKN3" "hsa:1033; Q16667; Q53ZU6; Q5U0M4; Q6P1N8; Q99585; Q9BPW7; Q9BY36; Q9C042; Q9C046; Q9C047; Q9C049; Q9C051; Q9C053" "" "" "0" "0" "0.976" "0.957" "0.863" "0.826" "0.853" "0.615" "0.667" "0.688" "0.804" "491.1" "479.2" "470.0" "423.8" "405.6" "419.1" "302.0" "327.7" "337.8" "395.1" "" "" "" "" "" "" "" "" "" "" "394.4" "345.8" "373.4" "284.0" "280.5" "314.5" "211.5" "239.3" "337.8" "321.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7327599600572382898" "False" "High" "IsMasterProtein" "P08473" "Neprilysin OS=Homo sapiens OX=9606 GN=MME PE=1 SV=2" "0.000" "False" "4.477" "3" "2" "2" "2" "750" "85.5" "5.73" "2.91" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01431, Pf05649" "4311" "ENSG00000196549" "MME" "A8K6U6; D3DNJ9; hsa:4311; P08473; Q3MIX4" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Physiological factors" "Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease" "6" "0" "1.219" "1.005" "1.289" "1.308" "1.231" "1.570" "1.073" "1.184" "1.286" "34.6" "42.2" "34.8" "44.6" "45.2" "42.6" "54.3" "37.1" "40.9" "44.5" "" "" "" "" "" "" "" "" "" "" "27.8" "30.4" "27.6" "29.9" "31.3" "32.0" "38.0" "27.1" "40.9" "36.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697558618654746564" "False" "High" "IsMasterProtein" "Q92546" "RAB6A-GEF complex partner protein 2 OS=Homo sapiens OX=9606 GN=RGP1 PE=1 SV=1" "0.000" "False" "4.464" "3" "1" "1" "1" "391" "42.4" "5.96" "3.68" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf08737" "9827" "ENSG00000107185" "RGP1" "hsa:9827; Q5TCV5; Q92546" "RAB GEFs exchange GTP for GDP on RABs; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "0.998" "0.912" "1.034" "0.741" "0.807" "0.782" "0.688" "0.750" "0.860" "192.5" "192.2" "175.6" "199.1" "142.7" "155.3" "150.6" "132.5" "144.4" "165.5" "" "" "" "" "" "" "" "" "" "" "154.6" "138.7" "139.5" "133.4" "98.7" "116.5" "105.5" "96.7" "144.4" "134.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758554991952715701" "False" "High" "IsMasterProtein" "Q9C0F1" "Centrosomal protein of 44 kDa OS=Homo sapiens OX=9606 GN=CEP44 PE=1 SV=2" "0.000" "False" "4.458" "6" "2" "2" "2" "390" "44.1" "5.21" "5.30" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf15007" "80817" "ENSG00000164118" "CEP44" "A8K8W9; A8MW11; B3KT53; D3DP42; hsa:80817; Q8IXZ4; Q9C0F1" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2089333689475724176" "False" "High" "IsMasterProtein" "Q9BTM9" "Ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=URM1 PE=1 SV=1" "0.000" "False" "4.457" "13" "1" "2" "1" "101" "11.4" "4.67" "4.15" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf09138" "81605" "ENSG00000167118" "URM1" "B3KMH3; B4DV08; hsa:81605; Q5T4B4; Q9BTM9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5217952952055268548" "False" "High" "IsMasterProtein" "P49207" "Large ribosomal subunit protein eL34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3" "0.000" "False" "4.451" "15" "2" "2" "2" "117" "13.3" "11.47" "2.94" "2" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01199" "6164" "ENSG00000109475" "RPL34" "hsa:6164; P49207; Q6FG66; Q9BUZ2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.001" "1.457" "1.347" "1.228" "1.392" "1.397" "0.930" "1.390" "1.430" "33.5" "33.5" "48.8" "45.1" "41.1" "46.6" "46.8" "31.1" "46.5" "47.9" "" "" "" "" "" "" "" "" "" "" "26.9" "24.2" "38.7" "30.2" "28.4" "35.0" "32.7" "22.7" "46.5" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534068984681137235" "False" "High" "IsMasterProtein" "Q86WQ0" "Nuclear receptor 2C2-associated protein OS=Homo sapiens OX=9606 GN=NR2C2AP PE=1 SV=1" "0.000" "False" "4.442" "9" "1" "1" "1" "139" "15.9" "6.16" "3.04" "1" "" "nucleus" "" "" "126382" "ENSG00000184162" "NR2C2AP" "A6NGP7; B4DW92; hsa:126382; Q86WQ0" "Nuclear Receptor transcription pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8114492968310580525" "False" "High" "IsMasterProtein" "P98194" "Calcium-transporting ATPase type 2C member 1 OS=Homo sapiens OX=9606 GN=ATP2C1 PE=1 SV=3" "0.000" "False" "4.438" "1" "1" "1" "1" "919" "100.5" "6.74" "2.92" "1" "cell adhesion;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "27032" "ENSG00000017260" "ATP2C1" "B2RAT7; B4DSW3; B7Z3X9; G3XAH8; G8JLN9; hsa:27032; O76005; P98194; Q86V72; Q86V73; Q8N6V1; Q8NCJ7" "Ion transport by P-type ATPases" "" "1" "0" "1.033" "1.228" "1.175" "1.002" "0.962" "1.072" "0.936" "1.242" "0.946" "53.8" "55.6" "66.1" "63.3" "54.0" "51.8" "57.7" "50.4" "66.9" "51.0" "" "" "" "" "" "" "" "" "" "" "43.2" "40.2" "52.5" "42.4" "37.3" "38.9" "40.4" "36.8" "66.9" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1616730099319626279" "False" "High" "IsMasterProtein" "O43298" "Zinc finger and BTB domain-containing protein 43 OS=Homo sapiens OX=9606 GN=ZBTB43 PE=1 SV=1" "0.000" "False" "4.436" "5" "1" "1" "1" "467" "52.6" "5.76" "2.53" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651" "23099" "ENSG00000169155" "ZBTB43" "hsa:23099; O43298; Q5JU96" "" "" "0" "0" "0.972" "0.939" "1.069" "1.052" "0.779" "1.005" "1.149" "0.995" "1.156" "91.6" "89.0" "86.0" "97.9" "96.3" "71.4" "92.0" "105.2" "91.2" "105.8" "" "" "" "" "" "" "" "" "" "" "73.6" "64.2" "68.3" "65.6" "66.6" "53.6" "64.4" "76.9" "91.2" "86.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2482389970324570609" "False" "High" "IsMasterProtein" "Q9NZ71" "Regulator of telomere elongation helicase 1 OS=Homo sapiens OX=9606 GN=RTEL1 PE=1 SV=2" "0.000" "False" "4.431" "1" "1" "1" "1" "1219" "133.6" "8.29" "3.34" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf13307" "51750" "ENSG00000258366" "RTEL1" "A2A397; A2A398; B4DRM5; B4DYM3; B4E3N6; E1P5J4; E1P5J5; hsa:51750; Q5JTV3; Q5JTV4; Q9BW37; Q9H402; Q9H4X6; Q9NX25; Q9NZ71; Q9NZ73; Q9UPR4; Q9Y4R6" "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Telomere Extension By Telomerase; Cytosolic iron-sulfur cluster assembly" "Lung fibrosis" "4" "0" "1.168" "1.026" "0.937" "0.915" "0.940" "0.984" "1.060" "1.045" "1.105" "121.8" "142.3" "125.0" "114.2" "111.5" "114.5" "119.9" "129.2" "127.3" "134.7" "" "" "" "" "" "" "" "" "" "" "97.9" "102.7" "99.3" "76.5" "77.1" "85.9" "83.9" "94.3" "127.3" "109.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002844298631346291" "False" "High" "IsMasterProtein" "Q53H47" "Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens OX=9606 GN=SETMAR PE=1 SV=2" "0.000" "False" "4.429" "1" "1" "1" "1" "684" "78.0" "7.14" "3.14" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01359, Pf05033, Pf17906" "6419" "ENSG00000170364" "SETMAR" "B4DY74; E7EN68; hsa:6419; Q13579; Q1G668; Q53H47; Q96F41" "" "Histone modifications" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7234885358333908901" "False" "High" "IsMasterProtein" "O75915" "PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1" "0.000" "False" "4.415" "10" "2" "2" "2" "188" "21.6" "9.77" "2.12" "2" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "" "Pf03208" "10550" "ENSG00000144746" "ARL6IP5" "B2R6V5; hsa:10550; O75915; Q53ES3; Q5KU08" "Glutamate Neurotransmitter Release Cycle" "" "1" "0" "0.889" "0.832" "0.957" "0.919" "0.872" "0.897" "0.830" "0.809" "0.848" "257.1" "228.5" "213.8" "246.1" "236.3" "224.1" "230.6" "213.3" "208.0" "217.9" "" "" "" "" "" "" "" "" "" "" "206.5" "164.9" "169.8" "164.9" "163.4" "168.1" "161.5" "155.8" "208.0" "177.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7957513769242835484" "False" "High" "IsMasterProtein" "Q9Y5S1" "Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1" "0.000" "False" "4.400" "2" "1" "1" "1" "764" "85.9" "5.83" "2.33" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00520, Pf12796" "51393" "ENSG00000187688" "TRPV2" "A6NML2; A8K0Z0; hsa:51393; Q9Y5S1; Q9Y670" "TRP channels" "" "1" "0" "1.023" "0.629" "1.094" "0.959" "0.885" "1.018" "1.054" "0.878" "0.865" "29.9" "30.5" "18.8" "32.7" "28.6" "26.4" "30.4" "31.5" "26.2" "25.8" "" "" "" "" "" "" "" "" "" "" "24.0" "22.0" "14.9" "21.9" "19.8" "19.8" "21.3" "23.0" "26.2" "21.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5922561171571103134" "False" "High" "IsMasterProtein" "P29375" "Lysine-specific demethylase 5A OS=Homo sapiens OX=9606 GN=KDM5A PE=1 SV=3" "0.000" "False" "4.396" "1" "1" "1" "1" "1690" "192.0" "6.49" "3.00" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00628, Pf01388, Pf02373, Pf02375, Pf02928, Pf08429, Pf21323" "5927" "ENSG00000073614" "KDM5A" "A8MV76; hsa:5927; P29375; Q4LE72; Q86XZ1" "HDMs demethylate histones; Chromatin modifications during the maternal to zygotic transition (MZT)" "" "2" "0" "0.992" "1.057" "1.011" "1.044" "1.142" "1.171" "1.030" "1.203" "1.137" "59.7" "59.2" "63.1" "60.3" "62.3" "68.1" "69.9" "61.4" "71.8" "67.9" "" "" "" "" "" "" "" "" "" "" "47.9" "42.7" "50.1" "40.4" "43.1" "51.1" "48.9" "44.9" "71.8" "55.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5027095919971470310" "False" "High" "IsMasterProtein" "Q5VVJ2" "Deubiquitinase MYSM1 OS=Homo sapiens OX=9606 GN=MYSM1 PE=1 SV=1" "0.000" "False" "4.396" "1" "1" "1" "1" "828" "95.0" "5.53" "3.52" "1" "cell organization and biogenesis;protein metabolism;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf01398, Pf04433" "114803" "ENSG00000162601" "MYSM1" "A8KA54; B3KX65; hsa:114803; Q5VVJ2; Q68DD3; Q6AI53; Q7Z3G8; Q96PX3" "Metalloprotease DUBs" "" "1" "0" "1.074" "0.963" "1.031" "0.983" "0.964" "0.902" "0.944" "1.034" "1.102" "143.2" "153.8" "137.9" "147.7" "140.8" "138.1" "129.2" "135.2" "148.1" "157.9" "" "" "" "" "" "" "" "" "" "" "115.0" "111.0" "109.6" "98.9" "97.3" "103.6" "90.5" "98.7" "148.1" "128.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4531692626450091838" "False" "High" "IsMasterProtein" "Q05BQ5" "MBT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MBTD1 PE=1 SV=2" "0.000" "False" "4.394" "1" "1" "1" "1" "628" "70.5" "7.77" "4.07" "1" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02820, Pf21319" "54799" "ENSG00000011258" "MBTD1" "hsa:54799; Q05BQ5; Q6ZVU7; Q9NXU1" "" "Mesodermal commitment pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1620079779013632978" "False" "High" "IsMasterProtein" "Q6TDU7" "Dynein axonemal intermediate chain 7 OS=Homo sapiens OX=9606 GN=DNAI7 PE=1 SV=2" "0.000" "False" "4.388" "3" "2" "2" "1" "716" "83.1" "5.29" "4.75" "2" "" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf12366, Pf15927" "55259" "ENSG00000118307" "DNAI7" "B4DNP2; F5H6T6; Q17RL2; Q4G171; Q5U5K5; Q6TDU7; Q9NV50" "" "" "0" "0" "0.930" "0.957" "0.945" "1.189" "0.822" "0.925" "1.144" "0.930" "0.946" "109.3" "101.6" "104.6" "103.2" "129.9" "89.8" "101.1" "125.0" "101.6" "103.4" "" "" "" "" "" "" "" "" "" "" "87.8" "73.3" "83.1" "69.2" "89.9" "67.4" "70.8" "91.3" "101.6" "84.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4771647564776910413" "False" "High" "IsMasterProtein" "Q96JC9" "ELL-associated factor 1 OS=Homo sapiens OX=9606 GN=EAF1 PE=1 SV=1" "0.000" "False" "4.388" "10" "3" "3" "1" "268" "29.0" "5.40" "5.39" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09816" "85403" "ENSG00000144597" "EAF1" "B4E3F5; hsa:85403; Q8IW10; Q96JC9" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "" "3" "0" "1.053" "0.918" "0.976" "1.140" "0.969" "1.102" "1.058" "1.001" "1.028" "114.0" "120.0" "104.6" "111.2" "129.9" "110.5" "125.6" "120.6" "114.0" "117.2" "" "" "" "" "" "" "" "" "" "" "91.6" "86.6" "83.1" "74.5" "89.9" "82.9" "87.9" "88.1" "114.0" "95.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2598464737050709238" "False" "High" "IsMasterProtein" "Q96LD8" "Sentrin-specific protease 8 OS=Homo sapiens OX=9606 GN=SENP8 PE=1 SV=1" "0.000" "False" "4.375" "7" "2" "2" "2" "212" "24.1" "5.97" "6.06" "2" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf02902" "123228" "ENSG00000166192" "SENP8" "hsa:123228; Q96LD8; Q96QA4" "Neddylation; UCH proteinases" "" "2" "0" "0.983" "0.991" "1.043" "1.066" "1.039" "1.006" "0.984" "1.127" "1.037" "283.9" "279.1" "281.5" "296.1" "302.6" "294.9" "285.8" "279.3" "319.9" "294.3" "" "" "" "" "" "" "" "" "" "" "228.1" "201.4" "223.6" "198.4" "209.3" "221.3" "200.1" "204.0" "319.9" "239.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8991505405555366750" "False" "High" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "0.000" "False" "4.367" "2" "1" "1" "1" "518" "58.4" "9.11" "3.55" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2708904731044144793" "False" "High" "IsMasterProtein" "Q7Z3K6" "Mesoderm induction early response protein 3 OS=Homo sapiens OX=9606 GN=MIER3 PE=1 SV=2" "0.000" "False" "4.361" "2" "1" "2" "1" "550" "61.4" "4.51" "5.68" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "166968" "ENSG00000155545" "MIER3" "B4DRI9; B8ZZQ0; hsa:166968; Q5CZI0; Q68CS3; Q6MZS7; Q7Z3K6; Q86YG8; Q8NA13" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3478129203947577365" "False" "High" "IsMasterProtein" "Q93075" "Putative deoxyribonuclease TATDN2 OS=Homo sapiens OX=9606 GN=TATDN2 PE=1 SV=2" "0.000" "False" "4.357" "1" "1" "1" "1" "761" "85.0" "7.39" "3.43" "1" "" "nucleus" "other molecular function" "Pf01026" "9797" "ENSG00000157014" "TATDN2" "hsa:9797; Q3MIL9; Q5BKU0; Q93075" "XBP1(S) activates chaperone genes" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939280561053710644" "False" "High" "IsMasterProtein" "Q9P0T4" "Zinc finger protein 581 OS=Homo sapiens OX=9606 GN=ZNF581 PE=1 SV=1" "0.000" "False" "4.357" "5" "1" "1" "1" "197" "22.0" "8.82" "3.61" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "51545" "ENSG00000171425" "ZNF581" "B2RDM6; hsa:51545; Q9P0T4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529217331400882174" "False" "High" "IsMasterProtein" "Q8TC05" "Nuclear protein MDM1 OS=Homo sapiens OX=9606 GN=MDM1 PE=1 SV=2" "0.000" "False" "4.349" "2" "1" "1" "1" "714" "80.7" "9.11" "2.59" "1" "developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15501" "56890" "ENSG00000111554" "MDM1" "B4DM65; E7EPQ3; hsa:56890; O43406; Q8TC05; Q8WTV9; Q9NR04" "" "" "0" "0" "0.773" "0.845" "0.811" "1.020" "0.916" "0.896" "0.973" "1.100" "1.156" "61.8" "47.7" "52.2" "50.1" "63.0" "56.6" "55.4" "60.1" "67.9" "71.4" "" "" "" "" "" "" "" "" "" "" "49.6" "34.4" "41.4" "33.6" "43.6" "42.4" "38.8" "43.9" "67.9" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396940342238216990" "False" "High" "IsMasterProtein" "Q9H6Y2" "WD repeat-containing protein 55 OS=Homo sapiens OX=9606 GN=WDR55 PE=1 SV=2" "0.000" "False" "4.342" "3" "1" "1" "1" "383" "42.0" "4.92" "3.21" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf12894" "54853" "ENSG00000120314" "WDR55" "hsa:54853; Q9H6Y2; Q9NXK4" "" "" "0" "0" "0.869" "0.913" "0.872" "0.843" "0.849" "0.816" "0.855" "0.933" "0.914" "157.1" "136.5" "143.5" "137.0" "132.5" "133.4" "128.3" "134.4" "146.6" "143.7" "" "" "" "" "" "" "" "" "" "" "126.2" "98.5" "114.0" "91.8" "91.7" "100.1" "89.8" "98.1" "146.6" "116.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782034775898615298" "False" "High" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "0.000" "False" "4.328" "7" "2" "2" "2" "199" "23.6" "9.01" "5.79" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.048" "1.113" "1.022" "0.988" "1.009" "0.899" "0.998" "0.960" "0.964" "349.7" "366.5" "389.0" "357.5" "345.6" "352.7" "314.3" "349.0" "335.8" "337.1" "" "" "" "" "" "" "" "" "" "" "280.8" "264.5" "309.0" "239.5" "239.0" "264.7" "220.1" "254.9" "335.8" "274.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3107589471447250441" "False" "High" "IsMasterProtein" "Q9NV06" "DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2" "0.000" "False" "4.325" "2" "1" "1" "1" "445" "51.4" "9.19" "2.94" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04158, Pf08662" "25879" "ENSG00000164934" "DCAF13" "hsa:25879; Q3MII9; Q8NCH8; Q8TC51; Q96JY7; Q9NV06; Q9NZX3" "Neddylation; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5295951375825513477" "False" "High" "IsMasterProtein" "Q14186" "Transcription factor Dp-1 OS=Homo sapiens OX=9606 GN=TFDP1 PE=1 SV=1" "0.000" "False" "4.318" "5" "1" "1" "1" "410" "45.0" "6.05" "3.14" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf08781" "7027" "ENSG00000198176" "TFDP1" "B4DLQ9; hsa:7027; Q14186; Q5JSB4; Q8IZL5" "Oxidative Stress Induced Senescence; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional Regulation by E2F6; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; Transcriptional regulation of granulopoiesis; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Activation of NOXA and translocation to mitochondria; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; G1 to S cell cycle control; DYRK1A involvement regarding cell proliferation in brain development" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3568481181707392039" "False" "High" "IsMasterProtein" "P30307" "M-phase inducer phosphatase 3 OS=Homo sapiens OX=9606 GN=CDC25C PE=1 SV=2" "0.000" "False" "4.312" "3" "1" "1" "1" "473" "53.3" "6.79" "3.11" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00581, Pf06617" "995" "ENSG00000158402" "CDC25C" "D3DQB8; hsa:995; P30307; Q96PL3; Q9H168; Q9H2E8; Q9H2E9; Q9H2F1" "Activation of ATR in response to replication stress; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Polo-like kinase mediated events" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling pathway; p53 transcriptional gene network; CCL18 signaling pathway; DNA damage response; Monoamine transport" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3510096742418622379" "False" "High" "IsMasterProtein" "Q9UNY5" "Zinc finger protein 232 OS=Homo sapiens OX=9606 GN=ZNF232 PE=1 SV=2" "0.000" "False" "4.312" "3" "1" "1" "1" "444" "50.7" "6.60" "3.26" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7775" "ENSG00000167840" "ZNF232" "hsa:7775; I3L4J6; Q9UNY5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1043542800326556912" "False" "High" "IsMasterProtein" "Q9NRA0" "Sphingosine kinase 2 OS=Homo sapiens OX=9606 GN=SPHK2 PE=1 SV=2" "0.000" "False" "4.304" "2" "1" "1" "1" "654" "69.2" "6.95" "2.36" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00781, Pf19279" "56848" "ENSG00000063176" "SPHK2" "A0T4C8; B4DU87; hsa:56848; Q9BRN1; Q9H0Q2; Q9NRA0; Q9NWU7" "Sphingolipid de novo biosynthesis" "Sphingolipid pathway; S1P receptor signal transduction; Metabolism of sphingolipids in ER and Golgi apparatus; Sphingolipid metabolism: integrated pathway; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413341502298466110" "False" "High" "IsMasterProtein" "Q8WXK3" "Ankyrin repeat and SOCS box protein 13 OS=Homo sapiens OX=9606 GN=ASB13 PE=1 SV=2" "0.000" "False" "4.300" "6" "2" "2" "2" "278" "30.0" "6.81" "4.57" "2" "protein metabolism;other metabolic processes;signal transduction" "cytosol" "" "Pf07525, Pf12796" "79754" "ENSG00000196372" "ASB13" "A8K7Q6; D3DRR2; hsa:79754; Q8WXK3; Q96EP7; Q9H8Z1" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "0.666" "0.944" "1.037" "0.579" "0.638" "0.769" "0.812" "0.868" "0.764" "31.8" "21.2" "30.0" "33.0" "18.4" "20.3" "24.5" "25.8" "27.6" "24.3" "" "" "" "" "" "" "" "" "" "" "25.6" "15.3" "23.9" "22.1" "12.8" "15.2" "17.1" "18.9" "27.6" "19.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634766023329637374" "False" "High" "IsMasterProtein" "Q9HAF1" "Chromatin modification-related protein MEAF6 OS=Homo sapiens OX=9606 GN=MEAF6 PE=1 SV=1" "0.000" "False" "4.300" "12" "3" "4" "3" "191" "21.6" "9.32" "7.61" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf09340" "64769" "ENSG00000163875" "MEAF6" "B1AK64; hsa:64769; Q4F967; Q7Z311; Q86WE3; Q9HAF1" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "" "2" "0" "1.004" "1.010" "0.996" "0.948" "1.036" "0.965" "1.059" "1.062" "0.956" "211.4" "212.3" "213.4" "210.6" "200.5" "219.0" "204.1" "223.9" "224.6" "202.1" "" "" "" "" "" "" "" "" "" "" "169.8" "153.2" "169.5" "141.1" "138.6" "164.3" "142.9" "163.5" "224.6" "164.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3258853358595528558" "False" "High" "IsMasterProtein" "Q9H8T0" "AKT-interacting protein OS=Homo sapiens OX=9606 GN=AKTIP PE=1 SV=1" "0.000" "False" "4.296" "6" "1" "1" "1" "292" "33.1" "9.31" "3.57" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "64400" "ENSG00000166971" "AKTIP" "hsa:64400; Q503B1; Q53H38; Q9H8T0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3585506896184313716" "False" "High" "IsMasterProtein" "P63218" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens OX=9606 GN=GNG5 PE=1 SV=3" "0.000" "False" "4.293" "13" "1" "1" "1" "68" "7.3" "9.85" "2.86" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2787" "ENSG00000174021" "GNG5" "B2R5A0; hsa:2787; P30670; P63218; Q5VX54; Q61015" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Pathways in cancer" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260730847028697075" "False" "High" "IsMasterProtein" "Q9BU70" "tRNA (adenine(37)-N6)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMO PE=1 SV=2" "0.000" "False" "4.292" "4" "1" "1" "1" "441" "48.6" "7.17" "3.46" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01980" "51531" "ENSG00000136932" "TRMO" "hsa:51531; Q5T113; Q86SK0; Q9BU70; Q9NXJ7; Q9P0Q7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697788944595406904" "False" "High" "IsMasterProtein" "Q9H497" "Torsin-3A OS=Homo sapiens OX=9606 GN=TOR3A PE=1 SV=1" "0.000" "False" "4.287" "3" "1" "1" "1" "397" "46.2" "6.01" "3.29" "1" "" "ER/Golgi;nucleus" "other molecular function" "Pf06309, Pf21376" "64222" "ENSG00000186283" "TOR3A" "B4DSY0; B7ZB65; hsa:64222; Q5M7Y7; Q8WVA7; Q8WWM2; Q9H495; Q9H497; Q9H6E7" "" "" "0" "0" "1.065" "1.026" "1.105" "1.304" "1.070" "1.043" "1.122" "1.139" "1.008" "47.5" "50.7" "48.8" "52.5" "62.0" "50.9" "49.6" "53.4" "54.1" "47.9" "" "" "" "" "" "" "" "" "" "" "38.2" "36.6" "38.7" "35.2" "42.9" "38.2" "34.7" "39.0" "54.1" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2612097907356743072" "False" "High" "IsMasterProtein" "Q96HA8" "Protein N-terminal glutamine amidohydrolase OS=Homo sapiens OX=9606 GN=NTAQ1 PE=1 SV=2" "0.000" "False" "4.260" "5" "1" "1" "1" "205" "23.7" "5.78" "2.79" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf09764" "55093" "ENSG00000156795" "NTAQ1" "B4DE68; hsa:55093; Q96HA8; Q9NW95" "" "" "0" "0" "0.810" "0.887" "0.971" "0.966" "0.959" "0.986" "0.828" "0.995" "0.843" "99.7" "80.8" "88.4" "96.8" "96.3" "95.6" "98.4" "82.6" "99.2" "84.0" "" "" "" "" "" "" "" "" "" "" "80.1" "58.3" "70.2" "64.8" "66.6" "71.7" "68.9" "60.3" "99.2" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3562387644317083347" "False" "High" "IsMasterProtein" "Q8N3C0" "Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3" "0.000" "False" "4.255" "1" "2" "2" "2" "2202" "251.3" "7.09" "0.00" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf02889" "10973" "ENSG00000112249" "ASCC3" "E7EW23; hsa:10973; O43738; Q4G1A0; Q5VTN2; Q8N3C0; Q9H1I9; Q9H5A2; Q9NTR0" "ALKBH3 mediated reversal of alkylation damage" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7546150518504420539" "False" "High" "IsMasterProtein" "O00186" "Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2" "0.000" "False" "4.252" "2" "1" "1" "1" "592" "67.7" "7.80" "3.88" "1" "cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00995" "6814" "ENSG00000116266" "STXBP3" "A8K269; A8K5K7; hsa:6814; O00186; Q53FW1; Q86YJ3; Q9UPD7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation" "Insulin signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-586751030658289178" "False" "High" "IsMasterProtein" "Q9NZ53" "Podocalyxin-like protein 2 OS=Homo sapiens OX=9606 GN=PODXL2 PE=1 SV=1" "0.000" "False" "4.246" "4" "2" "2" "2" "605" "65.0" "4.34" "3.08" "2" "cell adhesion" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf06365" "50512" "ENSG00000114631" "PODXL2" "hsa:50512; Q6UVY4; Q8WUV6; Q9NZ53" "Cytosolic sulfonation of small molecules" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1481328465955125696" "False" "High" "IsMasterProtein" "Q8TCB7" "tRNA N(3)-methylcytidine methyltransferase METTL6 OS=Homo sapiens OX=9606 GN=METTL6 PE=1 SV=2" "0.000" "False" "4.243" "3" "1" "1" "1" "284" "33.2" "6.19" "3.23" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08242" "131965" "ENSG00000206562" "METTL6" "hsa:131965; Q8TCB7; Q96LU4" "" "" "0" "0" "1.083" "1.017" "1.079" "1.226" "1.132" "1.089" "0.936" "1.257" "1.166" "63.2" "68.5" "64.3" "68.3" "77.6" "71.6" "68.9" "59.2" "79.5" "73.7" "" "" "" "" "" "" "" "" "" "" "50.8" "49.4" "51.1" "45.7" "53.6" "53.7" "48.2" "43.2" "79.5" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6596351157083836724" "False" "High" "IsMasterProtein" "Q8NC56" "LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LEMD2 PE=1 SV=1" "0.000" "False" "4.242" "3" "1" "1" "1" "503" "56.9" "9.00" "3.07" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "" "Pf03020, Pf09402" "221496" "ENSG00000161904" "LEMD2" "B4DVH5; E7EVT2; Q5T972; Q5T974; Q8NC56" "Sealing of the nuclear envelope (NE) by ESCRT-III; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311926917854502333" "False" "High" "IsMasterProtein" "O43414" "ERI1 exoribonuclease 3 OS=Homo sapiens OX=9606 GN=ERI3 PE=1 SV=2" "0.000" "False" "4.240" "3" "1" "1" "1" "337" "37.2" "8.07" "3.45" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00929" "79033" "ENSG00000117419" "ERI3" "B1AK98; hsa:79033; O43414; Q5T2T7; Q5T2T9; Q5TG35; Q9BQA0; Q9UEB4" "" "" "0" "0" "1.103" "1.003" "1.047" "1.209" "1.175" "1.219" "1.252" "1.175" "1.110" "265.3" "292.7" "266.1" "277.7" "320.8" "311.7" "323.5" "332.0" "311.8" "294.5" "" "" "" "" "" "" "" "" "" "" "213.1" "211.2" "211.4" "186.1" "221.9" "233.9" "226.5" "242.5" "311.8" "239.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4759228075821596448" "False" "High" "IsMasterProtein" "Q8IZD2" "Inactive histone-lysine N-methyltransferase 2E OS=Homo sapiens OX=9606 GN=KMT2E PE=1 SV=1" "0.000" "False" "4.239" "1" "2" "2" "2" "1858" "204.8" "7.61" "6.28" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00856, Pf20826" "55904" "ENSG00000005483" "KMT2E" "B6ZDE4; B6ZDM3; hsa:55904; M4K8J3; Q6P5Y2; Q6PKG4; Q6T316; Q86TI3; Q86W12; Q86WG0; Q86WL2; Q8IV78; Q8IWR5; Q8IZD2; Q8NFF8; Q9NWE7" "" "Histone modifications" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "713100355738171482" "False" "High" "IsMasterProtein" "Q8N302" "Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens OX=9606 GN=AGGF1 PE=1 SV=2" "0.000" "False" "4.237" "2" "1" "1" "1" "714" "80.9" "5.44" "2.47" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity" "Pf00498, Pf01585, Pf17780" "55109" "ENSG00000164252" "AGGF1" "hsa:55109; O00581; Q53YS3; Q8N302; Q9BU84; Q9NW66" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "1.070" "1.045" "1.081" "0.968" "1.029" "1.080" "1.068" "1.010" "1.003" "169.3" "181.1" "176.9" "183.0" "163.8" "174.3" "182.9" "180.8" "170.9" "169.7" "" "" "" "" "" "" "" "" "" "" "136.0" "130.7" "140.5" "122.6" "113.3" "130.8" "128.1" "132.0" "170.9" "138.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4435404438671900713" "False" "High" "IsMasterProtein" "Q96N11" "Integrator complex subunit 15 OS=Homo sapiens OX=9606 GN=INTS15 PE=1 SV=1" "0.000" "False" "4.233" "5" "2" "2" "2" "449" "50.0" "7.69" "5.82" "2" "" "nucleus" "" "Pf14964" "79034" "ENSG00000146576" "INTS15" "Q96N11; Q9BQ43" "" "" "0" "0" "0.983" "1.072" "1.020" "0.999" "1.062" "1.061" "1.192" "1.112" "1.033" "282.5" "277.7" "302.9" "288.0" "282.2" "300.0" "299.7" "336.8" "314.2" "291.6" "" "" "" "" "" "" "" "" "" "" "226.9" "200.4" "240.6" "192.9" "195.2" "225.1" "209.8" "246.0" "314.2" "237.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7641291098458873844" "False" "High" "IsMasterProtein" "Q8IVF5" "Rho guanine nucleotide exchange factor TIAM2 OS=Homo sapiens OX=9606 GN=TIAM2 PE=1 SV=4" "0.000" "False" "4.232" "1" "1" "1" "1" "1701" "190.0" "7.21" "4.11" "1" "signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf00595, Pf00621, Pf18385" "26230" "ENSG00000146426" "TIAM2" "B2RP56; C9JZV2; hsa:26230; Q6NXN9; Q6ZUP9; Q8IVF5; Q9UFG6; Q9UKV9; Q9UKW0" "RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; PPARA activates gene expression" "Chemokine signaling pathway" "5" "0" "0.854" "1.068" "0.995" "1.134" "1.012" "0.935" "0.861" "0.969" "1.066" "80.7" "68.9" "86.2" "80.3" "91.5" "81.7" "75.4" "69.5" "78.2" "86.1" "" "" "" "" "" "" "" "" "" "" "64.8" "49.7" "68.4" "53.8" "63.3" "61.3" "52.8" "50.7" "78.2" "70.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342427626710048975" "False" "High" "IsMasterProtein" "Q96SW2" "Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1" "0.000" "False" "4.216" "5" "2" "2" "2" "442" "50.5" "5.63" "4.97" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02190, Pf03226" "51185" "ENSG00000113851" "CRBN" "B2R6H4; C9IZA9; C9JAH6; hsa:51185; Q6AI62; Q6NVZ0; Q96SW2; Q9UHW4" "Potential therapeutics for SARS" "" "1" "0" "1.074" "0.957" "1.060" "0.939" "1.095" "0.819" "1.227" "1.070" "1.113" "58.6" "62.9" "56.1" "62.1" "55.0" "64.1" "48.0" "71.9" "62.7" "65.2" "" "" "" "" "" "" "" "" "" "" "47.0" "45.4" "44.5" "41.6" "38.0" "48.1" "33.6" "52.5" "62.7" "53.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200056701513102621" "False" "High" "IsMasterProtein" "P12236" "ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4" "0.000" "False" "4.215" "3" "1" "2" "1" "298" "32.8" "9.74" "6.10" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf00153" "293" "ENSG00000169100; ENSG00000292334" "SLC25A6" "hsa:293; P12236; Q96C49" "Mitochondrial protein import; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Mitochondrial protein degradation; Influenza Virus Induced Apoptosis; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization" "Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease" "8" "0" "0.926" "1.022" "1.153" "1.087" "1.071" "1.153" "0.876" "1.126" "1.108" "284.6" "263.4" "290.8" "328.0" "309.3" "304.7" "328.2" "249.4" "320.5" "315.5" "" "" "" "" "" "" "" "" "" "" "228.6" "190.1" "231.0" "219.8" "213.9" "228.6" "229.8" "182.1" "320.5" "256.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2555590194794136668" "False" "High" "IsMasterProtein" "Q9C073" "Protein FAM117A OS=Homo sapiens OX=9606 GN=FAM117A PE=1 SV=1" "0.000" "False" "4.200" "2" "1" "1" "1" "453" "48.3" "8.31" "3.53" "1" "" "" "" "Pf15388" "81558" "ENSG00000121104" "FAM117A" "B7Z7Q3; hsa:81558; Q9C073" "" "" "0" "0" "1.122" "1.149" "0.923" "0.948" "1.008" "1.046" "0.977" "1.055" "1.092" "109.8" "123.2" "126.2" "101.4" "104.1" "110.7" "114.8" "107.2" "115.8" "119.9" "" "" "" "" "" "" "" "" "" "" "88.2" "88.9" "100.3" "67.9" "72.0" "83.1" "80.4" "78.3" "115.8" "97.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "34707929049350531" "False" "High" "IsMasterProtein" "P51151" "Ras-related protein Rab-9A OS=Homo sapiens OX=9606 GN=RAB9A PE=1 SV=1" "0.000" "False" "4.191" "7" "1" "1" "1" "201" "22.8" "5.47" "4.11" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "9367" "ENSG00000123595" "RAB9A" "A8K390; hsa:9367; P51151; Q6ICN1" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle" "Ebola virus infection in host; Measles virus infection" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3766879511259281877" "False" "High" "IsMasterProtein" "Q96CM8" "Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2" "0.000" "False" "4.181" "1" "1" "2" "1" "615" "68.1" "7.55" "5.93" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "80221" "ENSG00000167107" "ACSF2" "B4DFQ6; B4DHT5; B4DUF5; hsa:80221; Q96CM8; Q9H7G2" "Mitochondrial Fatty Acid Beta-Oxidation" "Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "3" "0" "1.072" "1.148" "1.115" "1.192" "1.130" "1.005" "1.010" "1.072" "1.242" "156.6" "168.0" "179.9" "174.7" "186.7" "177.0" "157.5" "158.2" "167.9" "194.6" "" "" "" "" "" "" "" "" "" "" "125.8" "121.2" "142.9" "117.1" "129.1" "132.8" "110.3" "115.6" "167.9" "158.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7498924071980765815" "False" "High" "IsMasterProtein" "Q9Y2G3" "Phospholipid-transporting ATPase IF OS=Homo sapiens OX=9606 GN=ATP11B PE=1 SV=2" "0.000" "False" "4.166" "1" "1" "1" "1" "1177" "134.1" "6.96" "3.37" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00702, Pf13246, Pf16209, Pf16212" "23200" "ENSG00000058063" "ATP11B" "hsa:23200; Q96FN1; Q9UKK7; Q9Y2G3" "Neutrophil degranulation; Ion transport by P-type ATPases" "" "2" "0" "1.069" "1.074" "1.258" "1.258" "1.178" "1.388" "1.127" "1.206" "1.202" "35.9" "38.3" "38.5" "45.1" "45.1" "42.3" "49.8" "40.4" "43.2" "43.1" "" "" "" "" "" "" "" "" "" "" "28.8" "27.7" "30.6" "30.2" "31.2" "31.7" "34.8" "29.5" "43.2" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5402246304287674254" "False" "High" "IsMasterProtein" "Q53R41" "FAST kinase domain-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD1 PE=1 SV=1" "0.000" "False" "4.165" "1" "1" "1" "1" "847" "97.3" "7.74" "3.77" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "79675" "ENSG00000138399" "FASTKD1" "hsa:79675; Q53R41; Q8N583; Q8TEA9; Q96JM5; Q96N71; Q9H6T4" "" "" "0" "0" "1.190" "1.055" "1.052" "1.090" "1.004" "1.155" "0.998" "1.109" "1.074" "171.3" "203.8" "180.8" "180.3" "186.7" "171.9" "197.9" "171.0" "190.0" "183.9" "" "" "" "" "" "" "" "" "" "" "137.6" "147.1" "143.6" "120.8" "129.1" "129.0" "138.6" "124.9" "190.0" "149.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8326576177653758886" "False" "High" "IsMasterProtein" "O60447" "Ecotropic viral integration site 5 protein homolog OS=Homo sapiens OX=9606 GN=EVI5 PE=1 SV=3" "0.000" "False" "4.151" "1" "1" "1" "1" "810" "92.9" "6.10" "3.11" "1" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;other molecular function" "Pf00566" "7813" "ENSG00000067208" "EVI5" "A6NKX8; B9A6J0; hsa:7813; O60447; Q9H1Y9" "" "" "0" "0" "1.267" "0.970" "1.001" "0.878" "0.912" "0.777" "0.950" "0.892" "1.009" "32.0" "40.6" "31.1" "32.1" "28.1" "29.2" "24.9" "30.4" "28.6" "32.3" "" "" "" "" "" "" "" "" "" "" "25.7" "29.3" "24.7" "21.5" "19.5" "21.9" "17.4" "22.2" "28.6" "26.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1562013219529803649" "False" "High" "IsMasterProtein" "P15391" "B-lymphocyte antigen CD19 OS=Homo sapiens OX=9606 GN=CD19 PE=1 SV=6" "0.000" "False" "4.149" "3" "1" "2" "1" "556" "61.1" "4.98" "5.19" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "" "930" "ENSG00000177455" "CD19" "A0N0P9; F5H635; hsa:930; P15391; Q96S68; Q9BRD6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "B cell receptor signaling pathway; Complement system; PI3K-Akt signaling pathway; Leukocyte-intrinsic Hippo pathway functions; 16p11.2 distal deletion syndrome; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "336772770148819757" "False" "High" "IsMasterProtein" "Q9NVR0" "Kelch-like protein 11 OS=Homo sapiens OX=9606 GN=KLHL11 PE=1 SV=1" "0.000" "False" "4.146" "1" "1" "1" "1" "708" "80.1" "6.16" "4.09" "1" "" "cytosol" "" "Pf00651, Pf01344, Pf07707" "55175" "ENSG00000178502" "KLHL11" "hsa:55175; Q9NVR0" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4484612190120374131" "False" "High" "IsMasterProtein" "Q9Y6Y0" "Influenza virus NS1A-binding protein OS=Homo sapiens OX=9606 GN=IVNS1ABP PE=1 SV=3" "0.000" "False" "4.136" "3" "2" "2" "2" "642" "71.7" "5.53" "4.51" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707" "10625" "ENSG00000116679" "IVNS1ABP" "A8K8R6; hsa:10625; Q1G4T6; Q1G4T7; Q5TF75; Q6NW38; Q7LCG2; Q9NZX0; Q9Y480; Q9Y6Y0" "" "" "0" "0" "1.062" "1.093" "1.065" "1.099" "1.073" "1.056" "1.009" "1.072" "1.048" "77.4" "82.2" "84.6" "82.5" "85.0" "83.1" "81.8" "78.1" "82.9" "81.1" "" "" "" "" "" "" "" "" "" "" "62.2" "59.3" "67.2" "55.2" "58.8" "62.3" "57.2" "57.0" "82.9" "66.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8605151959694531472" "False" "High" "IsMasterProtein" "Q13888" "General transcription factor IIH subunit 2 OS=Homo sapiens OX=9606 GN=GTF2H2 PE=1 SV=1" "0.000" "False" "4.134" "2" "1" "2" "1" "395" "44.4" "6.76" "4.12" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus" "other molecular function" "Pf04056, Pf07975" "2966" "ENSG00000145736; ENSG00000275045; ENSG00000276910" "GTF2H2" "hsa:2966; Q13888; Q15570; Q15571; Q9BS41" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "33" "0" "1.078" "1.008" "1.013" "1.045" "1.069" "1.042" "1.013" "1.098" "1.017" "321.4" "346.3" "323.8" "325.4" "335.8" "343.7" "334.8" "325.4" "352.7" "326.7" "" "" "" "" "" "" "" "" "" "" "258.1" "249.9" "257.2" "218.0" "232.2" "257.8" "234.4" "237.6" "352.7" "265.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7500811780682688662" "False" "High" "IsMasterProtein" "Q8N8S7" "Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2" "0.000" "False" "4.131" "3" "2" "2" "1" "591" "66.5" "6.93" "2.41" "2" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "55740" "ENSG00000154380" "ENAH" "D0PQI2; hsa:55740; Q502W5; Q5T5M7; Q5VTQ9; Q5VTR0; Q8N8S7; Q9NVF3; Q9UFB8" "Generation of second messenger molecules; Signaling by ROBO receptors" "Regulation of actin cytoskeleton" "3" "0" "1.511" "1.325" "1.329" "1.906" "1.439" "1.226" "1.318" "1.764" "1.148" "14.8" "22.4" "19.6" "19.7" "28.2" "21.3" "18.2" "19.5" "26.1" "17.0" "" "" "" "" "" "" "" "" "" "" "11.9" "16.2" "15.6" "13.2" "19.5" "16.0" "12.7" "14.3" "26.1" "13.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4572995838386066943" "False" "High" "IsMasterProtein" "Q13568" "Interferon regulatory factor 5 OS=Homo sapiens OX=9606 GN=IRF5 PE=1 SV=2" "0.000" "False" "4.126" "4" "2" "2" "2" "498" "56.0" "5.77" "4.81" "2" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3663" "ENSG00000128604" "IRF5" "A4D1J8; A8DUA8; A8DUA9; E7EQ16; E7EW54; hsa:3663; Q13568; Q1A7B4; Q64GA9; Q64GB1; Q64GB2; Q6RCM8; Q9BQF0" "Interferon gamma signaling; Interferon alpha/beta signaling" "Apoptosis; Vitamin D receptor pathway; miRNA role in immune response in sepsis; p53 transcriptional gene network; Genes associated with the development of rheumatoid arthritis; Orexin receptor pathway; Toll-like receptor signaling pathway" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-72385411951020745" "False" "High" "IsMasterProtein" "Q5VUM1" "Succinate dehydrogenase assembly factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF4 PE=1 SV=1" "0.000" "False" "4.125" "9" "1" "1" "1" "108" "12.2" "9.36" "3.74" "1" "cell organization and biogenesis;other metabolic processes;stress response" "mitochondrion" "enzyme regulator activity" "Pf07896" "135154" "ENSG00000154079" "SDHAF4" "E1P532; hsa:135154; Q5VUM1" "" "Mitochondrial complex II assembly" "1" "0" "1.121" "1.020" "1.023" "1.013" "1.103" "1.055" "1.104" "0.989" "0.967" "157.2" "176.2" "160.3" "160.7" "159.2" "173.3" "165.8" "173.6" "155.4" "152.1" "" "" "" "" "" "" "" "" "" "" "126.2" "127.1" "127.3" "107.7" "110.1" "130.1" "116.1" "126.7" "155.4" "123.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4031307080017597315" "False" "High" "IsMasterProtein" "P18077" "Large ribosomal subunit protein eL33 OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2" "0.000" "False" "4.114" "13" "2" "4" "2" "110" "12.5" "11.06" "12.57" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01247" "6165" "ENSG00000182899" "RPL35A" "hsa:6165; P18077; Q08ES9; Q9BVN7" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "1.316" "1.306" "1.321" "1.214" "1.713" "1.183" "0.898" "1.294" "1.574" "184.7" "243.1" "241.3" "244.0" "224.1" "316.4" "218.4" "165.8" "239.1" "290.7" "" "" "" "" "" "" "" "" "" "" "148.3" "175.4" "191.6" "163.4" "155.0" "237.4" "152.9" "121.1" "239.1" "236.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1697211468385276031" "False" "High" "IsMasterProtein" "P62861" "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=2" "0.000" "False" "4.114" "8" "1" "2" "1" "133" "14.4" "10.17" "5.71" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00240, Pf04758" "2197" "ENSG00000149806" "FAU" "hsa:2197; P35544; P62861; Q05472; Q95261; Q9H5V4" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.269" "1.338" "1.380" "1.258" "1.279" "1.413" "1.114" "1.239" "1.188" "36.6" "46.5" "49.0" "50.6" "46.1" "46.9" "51.8" "40.8" "45.4" "43.5" "" "" "" "" "" "" "" "" "" "" "29.4" "33.5" "38.9" "33.9" "31.9" "35.2" "36.3" "29.8" "45.4" "35.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5901814721160308162" "False" "High" "IsMasterProtein" "Q9UBS0" "Ribosomal protein S6 kinase beta-2 OS=Homo sapiens OX=9606 GN=RPS6KB2 PE=1 SV=2" "0.000" "False" "4.100" "4" "2" "3" "2" "482" "53.4" "7.34" "7.41" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6199" "ENSG00000175634" "RPS6KB2" "B2RMZ9; B4DML8; hsa:6199; O94809; Q9UBS0; Q9UEC1" "AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Follicle stimulating hormone (FSH) signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Pleural mesothelioma; Acute myeloid leukemia; ErbB signaling pathway" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7612654384258451191" "False" "High" "IsMasterProtein" "Q13571" "Lysosomal-associated transmembrane protein 5 OS=Homo sapiens OX=9606 GN=LAPTM5 PE=1 SV=1" "0.000" "False" "4.099" "5" "1" "1" "1" "262" "29.9" "8.68" "2.57" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03821" "7805" "ENSG00000162511" "LAPTM5" "hsa:7805; Q13240; Q13571; Q14698; Q3KP54" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5573084200900719321" "False" "High" "IsMasterProtein" "Q9Y5V0" "Zinc finger protein 706 OS=Homo sapiens OX=9606 GN=ZNF706 PE=1 SV=1" "0.000" "False" "4.093" "24" "2" "3" "2" "76" "8.5" "10.01" "3.54" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf04419, Pf12874" "51123" "ENSG00000120963" "ZNF706" "A8K362; hsa:51123; Q9Y5V0" "Generic Transcription Pathway" "" "1" "0" "0.927" "0.995" "0.955" "0.773" "1.121" "0.965" "0.818" "0.884" "0.965" "189.9" "176.1" "189.0" "181.4" "146.8" "212.9" "183.2" "155.4" "167.8" "183.3" "" "" "" "" "" "" "" "" "" "" "152.5" "127.1" "150.1" "121.6" "101.5" "159.7" "128.3" "113.5" "167.8" "149.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7152432727454643144" "False" "High" "IsMasterProtein" "Q6PII3" "Coiled-coil domain-containing protein 174 OS=Homo sapiens OX=9606 GN=CCDC174 PE=1 SV=3" "0.000" "False" "4.091" "3" "2" "2" "2" "467" "53.9" "6.33" "5.21" "2" "" "nucleus" "" "Pf13300" "51244" "ENSG00000154781" "CCDC174" "hsa:51244; Q6PII3; Q96CS5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8166757714401601180" "False" "High" "IsMasterProtein" "O75964" "ATP synthase subunit g, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MG PE=1 SV=3" "0.000" "False" "4.069" "13" "1" "1" "1" "103" "11.4" "9.64" "2.99" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf04718" "10632" "ENSG00000167283" "ATP5MG" "A8K0K3; hsa:10632; O75964; Q96BV6; Q9UBZ7" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2506181633878019200" "False" "High" "IsMasterProtein" "P50548" "ETS domain-containing transcription factor ERF OS=Homo sapiens OX=9606 GN=ERF PE=1 SV=2" "0.000" "False" "4.067" "3" "2" "2" "1" "548" "58.7" "7.30" "2.50" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "2077" "ENSG00000105722" "ERF" "B2RAP1; B7Z4R0; hsa:2077; P50548; Q59G38; Q9UPI7" "Oncogene Induced Senescence" "Ciliary landscape" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3008882847524475916" "False" "High" "IsMasterProtein" "Q15041" "ADP-ribosylation factor-like protein 6-interacting protein 1 OS=Homo sapiens OX=9606 GN=ARL6IP1 PE=1 SV=2" "0.000" "False" "4.047" "5" "1" "1" "1" "203" "23.3" "9.32" "3.88" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "" "23204" "ENSG00000170540" "ARL6IP1" "B7Z6S5; B7Z791; F5GXP4; hsa:23204; Q15041" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751466246164002184" "False" "High" "IsMasterProtein" "O60613" "Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4" "0.000" "False" "4.046" "7" "1" "1" "1" "165" "18.1" "5.03" "2.65" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf08806" "9403" "ENSG00000183291" "SELENOF" "A0A0B4J1S4; hsa:9403; O60613; Q4GZG7; Q8WU00; Q9BS64; Q9GZW0; Q9NR01" "" "Selenium metabolism / selenoproteins; Selenium micronutrient network" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7626415837055227523" "False" "High" "IsMasterProtein" "Q7Z628" "Neuroepithelial cell-transforming gene 1 protein OS=Homo sapiens OX=9606 GN=NET1 PE=1 SV=1" "0.000" "False" "4.046" "2" "1" "1" "1" "596" "67.7" "9.23" "3.08" "1" "stress response;signal transduction;other biological processes" "cytosol;nucleus" "enzyme regulator activity" "Pf00169, Pf00621" "10276" "ENSG00000173848" "NET1" "hsa:10276; Q12773; Q7Z628; Q96D82; Q99903; Q9UEN6" "RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "5" "0" "0.973" "0.870" "0.965" "0.941" "0.748" "0.881" "1.044" "1.014" "0.875" "120.4" "117.2" "104.8" "116.2" "113.3" "90.1" "106.1" "125.7" "122.1" "105.3" "" "" "" "" "" "" "" "" "" "" "96.7" "84.6" "83.2" "77.8" "78.4" "67.6" "74.3" "91.8" "122.1" "85.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530814954955127226" "False" "High" "IsMasterProtein" "Q9UKV0" "Histone deacetylase 9 OS=Homo sapiens OX=9606 GN=HDAC9 PE=1 SV=2" "0.000" "False" "4.042" "2" "1" "1" "1" "1011" "111.2" "6.89" "3.31" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850, Pf12203" "9734" "ENSG00000048052" "HDAC9" "A7E2F3; B7Z4I4; B7Z917; B7Z928; B7Z940; C9JS87; E7EX34; F8W9E0; hsa:9734; O94845; O95028; Q2M2R6; Q86SL1; Q86US3; Q9UKV0" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7769023371860008745" "False" "High" "IsMasterProtein" "Q8N5I2" "Arrestin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARRDC1 PE=1 SV=1" "0.000" "False" "4.038" "3" "1" "1" "1" "433" "46.0" "7.02" "3.08" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf00339, Pf02752" "92714" "ENSG00000197070" "ARRDC1" "hsa:92714; Q8N5I2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5143535617621486292" "False" "High" "IsMasterProtein" "Q8IXK0" "Polyhomeotic-like protein 2 OS=Homo sapiens OX=9606 GN=PHC2 PE=1 SV=1" "0.000" "False" "4.024" "2" "1" "1" "1" "858" "90.7" "8.69" "2.65" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00536, Pf16616, Pf21319" "1912" "ENSG00000134686" "PHC2" "A1L4Q1; A8KA40; D3DPR2; hsa:1912; Q2TAL3; Q5T0C1; Q6NUJ6; Q6ZQR1; Q8IXK0; Q8N306; Q8TAG8; Q96BL4; Q9Y4Y7" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription" "" "8" "0" "1.219" "0.944" "1.143" "1.189" "1.062" "1.220" "1.085" "1.125" "1.097" "66.6" "81.2" "62.9" "76.1" "79.2" "70.7" "81.2" "72.3" "74.9" "73.0" "" "" "" "" "" "" "" "" "" "" "53.5" "58.6" "49.9" "51.0" "54.8" "53.1" "56.9" "52.8" "74.9" "59.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1790933947294059226" "False" "High" "IsMasterProtein" "Q9H477" "Ribokinase OS=Homo sapiens OX=9606 GN=RBKS PE=1 SV=1" "0.000" "False" "4.021" "3" "1" "1" "1" "322" "34.1" "5.05" "2.77" "1" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "64080" "ENSG00000171174" "RBKS" "A9UK04; B4DV96; hsa:64080; Q9H477" "Pentose phosphate pathway" "" "1" "0" "0.728" "0.879" "0.878" "0.775" "0.688" "0.945" "0.830" "0.769" "0.746" "40.2" "29.3" "35.3" "35.3" "31.1" "27.7" "38.0" "33.4" "30.9" "30.0" "" "" "" "" "" "" "" "" "" "" "32.3" "21.1" "28.1" "23.6" "21.5" "20.7" "26.6" "24.4" "30.9" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4814952899286626419" "False" "High" "IsMasterProtein" "P31151" "Protein S100-A7 OS=Homo sapiens OX=9606 GN=S100A7 PE=1 SV=4" "0.000" "False" "4.019" "11" "1" "1" "1" "101" "11.5" "6.77" "3.27" "1" "stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01023" "6278" "ENSG00000143556" "S100A7" "hsa:6278; P31151; Q5SY67; Q6FGE3; Q9H1E2" "Neutrophil degranulation; Metal sequestration by antimicrobial proteins" "" "2" "0" "0.464" "0.407" "0.484" "0.638" "1.088" "0.776" "0.553" "0.837" "0.759" "132.4" "61.4" "54.0" "64.1" "84.5" "144.1" "102.7" "73.3" "110.8" "100.5" "" "" "" "" "" "" "" "" "" "" "106.3" "44.3" "42.9" "42.9" "58.4" "108.1" "71.9" "53.5" "110.8" "81.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7346476942521402077" "False" "High" "IsMasterProtein" "Q9BUT9" "MAPK regulated corepressor interacting protein 2 OS=Homo sapiens OX=9606 GN=MCRIP2 PE=1 SV=2" "0.000" "False" "4.018" "7" "1" "1" "1" "160" "17.8" "9.41" "3.02" "1" "" "nucleus;other cell component" "" "Pf14799" "84331" "ENSG00000172366" "MCRIP2" "hsa:84331; Q969E9; Q96KV8; Q9BUT9" "" "" "0" "0" "0.937" "1.112" "1.179" "1.193" "1.169" "1.061" "1.147" "1.197" "1.106" "63.1" "59.1" "70.2" "74.4" "75.3" "73.7" "67.0" "72.4" "75.5" "69.8" "" "" "" "" "" "" "" "" "" "" "50.7" "42.7" "55.7" "49.9" "52.1" "55.3" "46.9" "52.9" "75.5" "56.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2007985770655079458" "False" "High" "IsMasterProtein" "Q9BPX6" "Calcium uptake protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MICU1 PE=1 SV=1" "0.000" "False" "4.017" "4" "3" "3" "3" "476" "54.3" "8.41" "6.66" "3" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13202" "10367" "ENSG00000107745" "MICU1" "A8MV96; B3KN20; B4DJH9; B4DPI1; B5MBY3; D3YTJ3; hsa:10367; O75785; Q9BPX6; Q9H9N6; Q9UFX0" "Processing of SMDT1" "" "2" "0" "1.067" "1.030" "1.071" "1.094" "1.036" "1.107" "0.987" "1.131" "1.130" "160.9" "171.7" "165.7" "172.3" "176.0" "166.7" "178.1" "158.8" "181.9" "181.7" "" "" "" "" "" "" "" "" "" "" "129.2" "123.9" "131.6" "115.4" "121.7" "125.1" "124.7" "116.0" "181.9" "147.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2638301692080516805" "False" "High" "IsMasterProtein" "O95817" "BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3" "0.000" "False" "4.017" "2" "1" "1" "1" "575" "61.6" "6.95" "2.96" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf02179" "9531" "ENSG00000151929" "BAG3" "A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120" "Regulation of HSF1-mediated heat shock response" "Cell interactions of the pancreatic cancer microenvironment" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4281551287497306931" "False" "High" "IsMasterProtein" "Q9Y2B9" "cAMP-dependent protein kinase inhibitor gamma OS=Homo sapiens OX=9606 GN=PKIG PE=1 SV=1" "0.000" "False" "4.009" "20" "1" "2" "1" "76" "7.9" "4.25" "2.48" "1" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf02827" "11142" "ENSG00000168734" "PKIG" "hsa:11142; Q9Y2B9" "" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5366408655713326940" "False" "High" "IsMasterProtein" "Q07817" "Bcl-2-like protein 1 OS=Homo sapiens OX=9606 GN=BCL2L1 PE=1 SV=1" "0.000" "False" "4.006" "4" "1" "1" "1" "233" "26.0" "4.93" "3.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00452, Pf02180" "598" "ENSG00000171552" "BCL2L1" "E1P5L6; hsa:598; Q07817; Q5CZ89; Q5TE65; Q92976" "Interleukin-4 and Interleukin-13 signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; RAS processing; NFE2L2 regulating tumorigenic genes; The NLRP1 inflammasome; STAT5 activation downstream of FLT3 ITD mutants; SARS-CoV-1-mediated effects on programmed cell death" "Leptin signaling pathway; IL-7 signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); IL-3 signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; lncRNA-mediated mechanisms of therapeutic resistance; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis" "32" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2927225253202889871" "False" "High" "IsMasterProtein" "P20701" "Integrin alpha-L OS=Homo sapiens OX=9606 GN=ITGAL PE=1 SV=3" "0.001" "False" "3.989" "1" "1" "1" "1" "1170" "128.7" "5.63" "2.75" "1" "cell adhesion;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00092, Pf00357, Pf01839, Pf08441, Pf20805" "3683" "ENSG00000005844" "ITGAL" "hsa:3683; O43746; P20701; Q45H73; Q96HB1; Q9UBC8" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; RUNX3 Regulates Immune Response and Cell Migration" "Integrin-mediated cell adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Leukocyte-intrinsic Hippo pathway functions; CCL18 signaling pathway" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8000898244145096963" "False" "High" "IsMasterProtein" "Q16533" "snRNA-activating protein complex subunit 1 OS=Homo sapiens OX=9606 GN=SNAPC1 PE=1 SV=1" "0.001" "False" "3.954" "6" "2" "2" "1" "368" "43.0" "9.51" "4.40" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09808" "6617" "ENSG00000023608" "SNAPC1" "hsa:6617; Q16533" "RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "" "3" "0" "0.985" "0.856" "1.180" "0.893" "0.936" "0.918" "0.844" "1.057" "1.118" "22.1" "21.8" "19.0" "26.1" "19.8" "20.7" "20.3" "18.7" "23.4" "24.8" "" "" "" "" "" "" "" "" "" "" "17.8" "15.7" "15.1" "17.5" "13.7" "15.5" "14.2" "13.7" "23.4" "20.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5038635126872872861" "False" "High" "IsMasterProtein" "O15015" "Zinc finger protein 646 OS=Homo sapiens OX=9606 GN=ZNF646 PE=1 SV=2" "0.001" "False" "3.953" "2" "2" "3" "2" "1832" "200.7" "7.21" "0.00" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "9726" "ENSG00000167395" "ZNF646" "hsa:9726; O15015; Q8IVD8" "" "" "0" "0" "0.833" "0.645" "0.766" "0.736" "0.652" "0.894" "0.636" "0.761" "0.601" "20.5" "17.1" "13.2" "15.7" "15.1" "13.4" "18.4" "13.0" "15.6" "12.3" "" "" "" "" "" "" "" "" "" "" "16.5" "12.3" "10.5" "10.5" "10.5" "10.0" "12.9" "9.5" "15.6" "10.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357357949464127480" "False" "High" "IsMasterProtein" "O75503" "Bis(monoacylglycero)phosphate synthase CLN5 OS=Homo sapiens OX=9606 GN=CLN5 PE=1 SV=2" "0.001" "False" "3.946" "3" "1" "1" "1" "358" "41.5" "7.40" "2.23" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15014" "1203" "ENSG00000102805" "CLN5" "B3KQK7; hsa:1203; O75503" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293732190144876547" "False" "High" "IsMasterProtein" "P13498" "Cytochrome b-245 light chain OS=Homo sapiens OX=9606 GN=CYBA PE=1 SV=3" "0.001" "False" "3.944" "5" "1" "1" "1" "195" "21.0" "9.54" "3.76" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05038" "1535" "ENSG00000051523" "CYBA" "hsa:1535; P13498; Q14090; Q9BR72" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Neutrophil degranulation; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; WNT5:FZD7-mediated leishmania damping; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "TNF-alpha signaling pathway; Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256075444160653012" "False" "High" "IsMasterProtein" "Q5SVZ6" "Zinc finger MYM-type protein 1 OS=Homo sapiens OX=9606 GN=ZMYM1 PE=1 SV=1" "0.001" "False" "3.930" "1" "1" "1" "1" "1142" "128.6" "7.44" "3.48" "1" "" "nucleus" "other molecular function" "Pf05699, Pf06467, Pf14291" "79830" "ENSG00000197056" "ZMYM1" "D3DPR7; hsa:79830; Q5SVZ6; Q7Z3Q4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1712691201144917783" "False" "High" "IsMasterProtein" "Q9NRF2" "SH2B adapter protein 1 OS=Homo sapiens OX=9606 GN=SH2B1 PE=1 SV=3" "0.001" "False" "3.926" "3" "2" "2" "1" "756" "79.3" "5.38" "4.06" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "signal transduction activity or receptor binding" "Pf00017, Pf00169, Pf08916" "25970" "ENSG00000178188" "SH2B1" "A8K2R7; hsa:25970; Q96FK3; Q96SX3; Q9NRF1; Q9NRF2; Q9NRF3; Q9P2P7; Q9Y3Y3" "Factors involved in megakaryocyte development and platelet production" "Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; 16p11.2 distal deletion syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4390061241352575470" "False" "High" "IsMasterProtein" "Q9HC07" "Putative divalent cation/proton antiporter TMEM165 OS=Homo sapiens OX=9606 GN=TMEM165 PE=1 SV=1" "0.001" "False" "3.922" "6" "1" "1" "1" "324" "34.9" "7.02" "2.61" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01169" "55858" "ENSG00000134851" "TMEM165" "A8K3P8; B4DHW1; hsa:55858; Q9BTN9; Q9HC07; Q9NZ34" "" "IL-18 signaling pathway" "1" "0" "1.034" "0.943" "0.885" "1.008" "1.000" "1.076" "0.941" "0.916" "1.099" "66.4" "68.7" "62.6" "58.7" "66.9" "66.4" "71.5" "62.5" "60.8" "73.0" "" "" "" "" "" "" "" "" "" "" "53.3" "49.5" "49.7" "39.4" "46.3" "49.8" "50.1" "45.6" "60.8" "59.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965244756027354747" "False" "High" "IsMasterProtein" "O75414" "Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3" "0.001" "False" "3.916" "7" "1" "1" "1" "186" "21.1" "8.32" "3.35" "1" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf00334" "10201" "ENSG00000172113" "NME6" "B4DGW7; B4DM99; hsa:10201; O75414; Q53HM5; Q96E73; Q9BQ63" "" "Pyrimidine metabolism" "1" "0" "0.850" "0.870" "0.891" "1.082" "0.865" "0.837" "0.861" "0.817" "0.965" "36.9" "31.4" "32.1" "32.9" "39.9" "31.9" "30.9" "31.8" "30.1" "35.6" "" "" "" "" "" "" "" "" "" "" "29.6" "22.6" "25.5" "22.0" "27.6" "24.0" "21.6" "23.2" "30.1" "28.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5427058765005465503" "False" "High" "IsMasterProtein" "Q7Z6I8" "UPF0461 protein C5orf24 OS=Homo sapiens OX=9606 GN=C5orf24 PE=1 SV=1" "0.001" "False" "3.882" "7" "1" "1" "1" "188" "20.1" "9.85" "2.74" "1" "" "" "" "Pf17724" "134553" "ENSG00000181904" "C5orf24" "D3DQA7; hsa:134553; Q7Z6I8; Q86Y53; Q8N1T9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6115091388662522029" "False" "High" "IsMasterProtein" "P55211" "Caspase-9 OS=Homo sapiens OX=9606 GN=CASP9 PE=1 SV=3" "0.001" "False" "3.878" "2" "1" "1" "1" "416" "46.3" "6.05" "2.84" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00656" "842" "ENSG00000132906" "CASP9" "B4E1A3; hsa:842; O95348; P55211; Q53Y70; Q5JRU9; Q5UGI1; Q92852; Q9BQ62; Q9UEQ3; Q9UIJ8" "Constitutive Signaling by AKT1 E17K in Cancer; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; NOD1/2 Signaling Pathway; AKT phosphorylates targets in the cytosol; Caspase activation via Dependence Receptors in the absence of ligand" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Hepatitis C and hepatocellular carcinoma; Apoptosis modulation by HSP70; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; miRNA regulation of p53 pathway in prostate cancer; NO/cGMP/PKG mediated neuroprotection; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; MTHFR deficiency; Acute viral myocarditis; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Complement system in neuronal development and plasticity; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "47" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5441876211868438473" "False" "High" "IsMasterProtein" "Q92585" "Mastermind-like protein 1 OS=Homo sapiens OX=9606 GN=MAML1 PE=1 SV=3" "0.001" "False" "3.878" "1" "1" "1" "1" "1016" "108.0" "8.28" "3.02" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09596, Pf20801, Pf20802" "9794" "ENSG00000161021; ENSG00000283780" "MAML1" "hsa:9794; Q92585; Q9NZ12" "NOTCH3 Intracellular Domain Regulates Transcription; Pre-NOTCH Transcription and Translation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Notch signaling; Canonical and non-canonical Notch signaling; Head and neck squamous cell carcinoma; Notch signaling pathway" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857109262484176384" "False" "High" "IsMasterProtein" "Q16342" "Programmed cell death protein 2 OS=Homo sapiens OX=9606 GN=PDCD2 PE=1 SV=2" "0.001" "False" "3.875" "6" "2" "2" "2" "344" "38.6" "5.38" "3.07" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01753, Pf04194" "5134" "ENSG00000071994" "PDCD2" "E9PCU7; F5GYS7; hsa:5134; Q16342; Q58HM9; Q58HN0; Q9UH12" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6579369189662832735" "False" "High" "IsMasterProtein" "Q8IX04" "Ubiquitin-conjugating enzyme E2 variant 3 OS=Homo sapiens OX=9606 GN=UEVLD PE=1 SV=2" "0.001" "False" "3.849" "3" "2" "2" "2" "471" "52.2" "7.09" "5.57" "2" "protein metabolism;other metabolic processes;transport" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00056, Pf02866, Pf05743" "55293" "ENSG00000151116" "UEVLD" "B2RB69; B4DL43; F5H6L6; H7BYD6; hsa:55293; Q6P2F0; Q8IX04; Q96FF5; Q9NUX7" "" "" "0" "0" "0.913" "0.898" "1.061" "0.924" "1.004" "0.860" "0.913" "0.965" "0.955" "263.8" "240.8" "236.9" "279.8" "243.8" "264.8" "226.8" "240.9" "254.5" "251.9" "" "" "" "" "" "" "" "" "" "" "211.8" "173.8" "188.2" "187.5" "168.6" "198.7" "158.8" "175.9" "254.5" "204.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5430220103658382973" "False" "High" "IsMasterProtein" "Q969Q0" "Ribosomal protein eL42-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3" "0.001" "False" "3.844" "8" "1" "3" "1" "106" "12.5" "10.65" "9.39" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus" "other molecular function" "Pf00935" "6166" "ENSG00000165502" "RPL36AL" "hsa:6166; Q3B7A5; Q969Q0" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "13" "0" "0.910" "1.101" "1.157" "1.232" "1.318" "1.470" "1.156" "1.269" "1.143" "203.6" "185.3" "224.1" "235.6" "250.8" "268.3" "299.4" "235.4" "258.4" "232.7" "" "" "" "" "" "" "" "" "" "" "163.5" "133.7" "178.0" "157.9" "173.4" "201.3" "209.6" "171.9" "258.4" "189.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8810414112164205375" "False" "High" "IsMasterProtein" "Q8WTW4" "GATOR1 complex protein NPRL2 OS=Homo sapiens OX=9606 GN=NPRL2 PE=1 SV=2" "0.001" "False" "3.820" "3" "1" "1" "1" "380" "43.6" "6.52" "4.25" "1" "stress response;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf06218" "10641" "ENSG00000114388" "NPRL2" "A8K831; hsa:10641; Q6FGS2; Q8WTW4; Q9Y249; Q9Y497" "Amino acids regulate mTORC1" "22q11.2 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469574299663466694" "False" "High" "IsMasterProtein" "P11233" "Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1" "0.001" "False" "3.811" "4" "1" "1" "1" "206" "23.6" "7.11" "3.36" "1" "cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00071" "5898" "ENSG00000006451" "RALA" "A4D1W3; hsa:5898; P11233" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; p38MAPK events" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "8" "0" "1.017" "0.897" "1.021" "0.947" "1.250" "1.133" "0.814" "1.178" "0.996" "89.3" "90.9" "80.2" "91.2" "84.6" "111.7" "101.2" "72.7" "105.3" "89.0" "" "" "" "" "" "" "" "" "" "" "71.8" "65.6" "63.7" "61.1" "58.5" "83.8" "70.8" "53.1" "105.3" "72.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5006155018502035980" "False" "High" "IsMasterProtein" "Q8WXI2" "Connector enhancer of kinase suppressor of ras 2 OS=Homo sapiens OX=9606 GN=CNKSR2 PE=1 SV=1" "0.001" "False" "3.803" "1" "1" "2" "1" "1034" "117.5" "6.79" "4.39" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00169, Pf00536, Pf00595, Pf06663, Pf10534" "22866" "ENSG00000149970" "CNKSR2" "B4DGR4; B7ZLJ1; B9EG83; E7ESA4; hsa:22866; O94976; Q5JPK4; Q5JPN0; Q8WXI1; Q8WXI2" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "" "7" "0" "0.622" "0.935" "0.789" "0.726" "0.753" "0.712" "0.831" "0.771" "0.828" "667.4" "414.9" "623.9" "526.7" "484.5" "502.3" "475.0" "554.3" "514.4" "552.8" "" "" "" "" "" "" "" "" "" "" "536.0" "299.4" "495.6" "352.9" "335.1" "376.8" "332.5" "404.8" "514.4" "449.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7421726054682487966" "False" "High" "IsMasterProtein" "Q9NX18" "Succinate dehydrogenase assembly factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF2 PE=1 SV=1" "0.001" "False" "3.803" "11" "2" "2" "2" "166" "19.6" "6.80" "4.88" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf03937" "54949" "ENSG00000167985" "SDHAF2" "hsa:54949; Q9NX18" "" "Mitochondrial complex II assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331965257696457103" "False" "High" "IsMasterProtein" "Q9H467" "CUE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CUEDC2 PE=1 SV=1" "0.001" "False" "3.798" "6" "2" "2" "2" "287" "32.0" "4.81" "3.72" "2" "other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02845" "79004" "ENSG00000107874" "CUEDC2" "D3DR88; hsa:79004; Q9BWG8; Q9H467" "" "" "0" "0" "1.006" "0.984" "1.018" "0.841" "0.885" "1.014" "1.085" "1.021" "0.942" "153.6" "154.5" "151.2" "156.3" "129.1" "135.9" "155.7" "166.6" "156.8" "144.7" "" "" "" "" "" "" "" "" "" "" "123.3" "111.5" "120.1" "104.7" "89.3" "102.0" "109.0" "121.7" "156.8" "117.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893746772392115503" "False" "High" "IsMasterProtein" "Q6P1L5" "Protein FAM117B OS=Homo sapiens OX=9606 GN=FAM117B PE=1 SV=2" "0.001" "False" "3.787" "5" "2" "2" "2" "589" "61.9" "9.82" "2.27" "2" "" "" "" "Pf15388" "150864" "ENSG00000138439" "FAM117B" "hsa:150864; Q53QZ5; Q585T9; Q6P1L5; Q8N8W1; Q96Q34" "" "" "0" "0" "1.445" "1.156" "1.243" "1.387" "1.193" "1.116" "1.474" "1.169" "0.974" "16.5" "23.9" "19.1" "20.6" "22.9" "19.7" "18.5" "24.4" "19.3" "16.1" "" "" "" "" "" "" "" "" "" "" "13.3" "17.2" "15.2" "13.8" "15.9" "14.8" "12.9" "17.8" "19.3" "13.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801865805934873113" "False" "High" "IsMasterProtein" "Q86YR5" "G-protein-signaling modulator 1 OS=Homo sapiens OX=9606 GN=GPSM1 PE=1 SV=2" "0.001" "False" "3.786" "1" "1" "1" "1" "675" "74.5" "6.54" "1.83" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf02188, Pf13424" "26086" "ENSG00000160360" "GPSM1" "A9Z1X4; B1B0W3; hsa:26086; Q86SR5; Q86YR5; Q969T1; Q9UFS8" "G alpha (i) signalling events" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465431971745530473" "False" "High" "IsMasterProtein" "Q3KRA9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Homo sapiens OX=9606 GN=ALKBH6 PE=1 SV=2" "0.001" "False" "3.777" "7" "2" "2" "2" "238" "26.5" "8.78" "4.31" "2" "" "nucleus;other cell component" "other molecular function" "Pf13532" "84964" "ENSG00000239382" "ALKBH6" "A5LGM8; A6NLP1; A8MU96; hsa:84964; Q3KRA9" "" "" "0" "0" "1.266" "1.338" "1.773" "1.128" "1.433" "1.284" "1.152" "1.538" "1.157" "10.1" "12.7" "13.5" "17.8" "11.3" "14.4" "12.9" "11.6" "15.5" "11.6" "" "" "" "" "" "" "" "" "" "" "8.1" "9.2" "10.7" "11.9" "7.8" "10.8" "9.0" "8.5" "15.5" "9.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6903887554392062573" "False" "High" "IsMasterProtein" "P35226" "Polycomb complex protein BMI-1 OS=Homo sapiens OX=9606 GN=BMI1 PE=1 SV=2" "0.001" "False" "3.777" "2" "1" "1" "1" "326" "36.9" "8.63" "3.33" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13923, Pf16207" "100532731; 648" "ENSG00000168283" "BMI1" "hsa:100532731; hsa:648; P35226; Q16030; Q5T8Z3; Q96F37" "Oxidative Stress Induced Senescence; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; CCL18 signaling pathway" "12" "0" "1.157" "1.221" "1.162" "1.015" "1.038" "1.121" "1.116" "1.116" "1.106" "117.9" "136.4" "143.9" "137.0" "119.7" "122.3" "132.1" "131.5" "131.6" "130.4" "" "" "" "" "" "" "" "" "" "" "94.7" "98.4" "114.3" "91.8" "82.8" "91.8" "92.5" "96.0" "131.6" "106.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4546155412470536460" "False" "High" "IsMasterProtein" "Q9NQS7" "Inner centromere protein OS=Homo sapiens OX=9606 GN=INCENP PE=1 SV=3" "0.001" "False" "3.774" "1" "1" "1" "1" "918" "105.4" "9.44" "3.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03941, Pf12178" "3619" "ENSG00000149503" "INCENP" "A8MQD2; hsa:3619; Q5Y192; Q9NQS7" "SUMOylation of DNA replication proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "0.977" "0.936" "1.053" "1.142" "0.998" "1.375" "1.025" "1.162" "1.119" "134.5" "131.4" "125.9" "141.5" "153.5" "134.1" "184.8" "137.8" "156.3" "150.4" "" "" "" "" "" "" "" "" "" "" "108.0" "94.8" "100.0" "94.8" "106.2" "100.6" "129.4" "100.7" "156.3" "122.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2438829351584223840" "False" "High" "IsMasterProtein" "O75529" "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L OS=Homo sapiens OX=9606 GN=TAF5L PE=1 SV=1" "0.001" "False" "3.773" "2" "1" "1" "1" "589" "66.1" "5.88" "3.41" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04494" "27097" "ENSG00000135801" "TAF5L" "hsa:27097; O75529; Q5TDI5; Q5TDI6; Q8IW31" "HATs acetylate histones" "" "1" "0" "0.997" "0.990" "0.955" "0.959" "0.850" "0.880" "1.100" "1.059" "0.986" "57.0" "56.8" "56.4" "54.4" "54.6" "48.4" "50.2" "62.7" "60.3" "56.2" "" "" "" "" "" "" "" "" "" "" "45.8" "41.0" "44.8" "36.4" "37.8" "36.3" "35.1" "45.8" "60.3" "45.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7264395322286508547" "False" "High" "IsMasterProtein" "Q6ZS11" "Ras and Rab interactor-like protein OS=Homo sapiens OX=9606 GN=RINL PE=1 SV=2" "0.001" "False" "3.764" "2" "1" "1" "1" "566" "62.4" "5.92" "3.24" "1" "transport" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02204" "126432" "ENSG00000187994; ENSG00000282895" "RINL" "B4DPG5; hsa:126432; Q6ZS11" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5734018844191392129" "False" "High" "IsMasterProtein" "Q96EN9" "Required for excision 1-B domain-containing protein OS=Homo sapiens OX=9606 GN=REX1BD PE=1 SV=1" "0.001" "False" "3.762" "11" "2" "2" "2" "201" "22.6" "6.96" "0.00" "2" "" "" "" "Pf14966" "55049" "ENSG00000006015" "REX1BD" "E9PAS0; hsa:55049; Q8NAX4; Q96EN9; Q9NWI0" "" "" "0" "0" "1.213" "1.144" "1.032" "0.987" "1.195" "1.109" "1.062" "1.232" "1.070" "96.2" "116.7" "110.0" "99.3" "94.9" "114.9" "106.7" "102.2" "118.5" "102.9" "" "" "" "" "" "" "" "" "" "" "77.3" "84.2" "87.4" "66.5" "65.7" "86.2" "74.7" "74.6" "118.5" "83.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1239746035430338710" "False" "High" "IsMasterProtein" "Q2T9J0" "Peroxisomal leader peptide-processing protease OS=Homo sapiens OX=9606 GN=TYSND1 PE=1 SV=3" "0.001" "False" "3.752" "2" "1" "1" "1" "566" "59.3" "6.20" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf13365" "219743" "ENSG00000156521" "TYSND1" "hsa:219743; Q2T9J0; Q5SQT4; Q5SQU1; Q8N6H2; Q96AR5" "TYSND1 cleaves peroxisomal proteins" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2707408667698188393" "False" "High" "IsMasterProtein" "Q53G59" "Kelch-like protein 12 OS=Homo sapiens OX=9606 GN=KLHL12 PE=1 SV=2" "0.001" "False" "3.739" "2" "1" "1" "1" "568" "63.2" "5.44" "2.82" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "59349" "ENSG00000117153" "KLHL12" "A6NEN8; B7Z7B8; hsa:59349; Q53G59; Q9HBX5" "Degradation of DVL" "" "1" "0" "0.956" "0.744" "0.978" "1.197" "1.119" "0.979" "0.780" "0.986" "0.795" "35.1" "33.6" "26.1" "34.4" "42.0" "39.3" "34.4" "27.4" "34.6" "27.9" "" "" "" "" "" "" "" "" "" "" "28.2" "24.2" "20.8" "23.0" "29.1" "29.5" "24.1" "20.0" "34.6" "22.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-829436805144986471" "False" "High" "IsMasterProtein" "P61927" "Large ribosomal subunit protein eL37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2" "0.001" "False" "3.733" "16" "2" "2" "2" "97" "11.1" "11.74" "4.92" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01907" "6167" "ENSG00000145592" "RPL37" "B2R4H2; hsa:6167; P02403; P61927; Q6IBB4; Q99883" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "0.681" "0.877" "0.917" "0.831" "1.124" "0.951" "0.942" "0.847" "0.846" "232.1" "158.1" "203.7" "212.8" "193.0" "260.9" "220.6" "218.6" "196.6" "196.3" "" "" "" "" "" "" "" "" "" "" "186.4" "114.0" "161.8" "142.6" "133.5" "195.8" "154.5" "159.7" "196.6" "159.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "462571488104407495" "False" "High" "IsMasterProtein" "Q86T24" "Transcriptional regulator Kaiso OS=Homo sapiens OX=9606 GN=ZBTB33 PE=1 SV=2" "0.001" "False" "3.726" "2" "2" "2" "2" "672" "74.4" "5.12" "2.78" "2" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651" "10009" "ENSG00000177485" "ZBTB33" "B2R5U6; hsa:10009; O00319; Q7Z361; Q86T24; Q8IVP6; Q8N3P0" "" "Wnt signaling pathway and pluripotency" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1905410913598438347" "False" "High" "IsMasterProtein" "Q96FN9" "D-aminoacyl-tRNA deacylase 2 OS=Homo sapiens OX=9606 GN=DTD2 PE=1 SV=1" "0.001" "False" "3.715" "6" "1" "1" "1" "168" "18.6" "7.84" "2.59" "1" "RNA metabolism OR transcription" "other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "112487" "ENSG00000129480" "DTD2" "D3DS87; hsa:112487; Q96FN9" "" "" "0" "0" "0.843" "0.832" "0.900" "0.903" "0.658" "0.761" "0.936" "0.849" "0.876" "30.9" "26.1" "25.7" "27.8" "27.9" "20.3" "23.5" "28.9" "26.2" "27.0" "" "" "" "" "" "" "" "" "" "" "24.8" "18.8" "20.4" "18.6" "19.3" "15.2" "16.5" "21.1" "26.2" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1862365170183324257" "False" "High" "IsMasterProtein" "P56182" "Ribosomal RNA processing protein 1 homolog A OS=Homo sapiens OX=9606 GN=RRP1 PE=1 SV=1" "0.001" "False" "3.702" "3" "1" "1" "1" "461" "52.8" "9.33" "2.36" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05997" "8568" "ENSG00000160214" "RRP1" "hsa:8568; P56182; Q9NST5" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.110" "0.974" "1.334" "0.974" "0.846" "1.132" "0.749" "0.931" "0.912" "14.0" "15.5" "13.6" "18.6" "13.6" "11.8" "15.8" "10.5" "13.0" "12.7" "" "" "" "" "" "" "" "" "" "" "11.2" "11.2" "10.8" "12.5" "9.4" "8.9" "11.1" "7.7" "13.0" "10.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782993936716415463" "False" "High" "IsMasterProtein" "Q96QE5" "Transcription elongation factor, mitochondrial OS=Homo sapiens OX=9606 GN=TEFM PE=1 SV=1" "0.001" "False" "3.702" "2" "1" "1" "1" "360" "41.7" "9.32" "3.47" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "enzyme regulator activity" "Pf12836" "79736" "ENSG00000172171" "TEFM" "E1P655; hsa:79736; Q6GPG5; Q6PJ19; Q96H04; Q96QE5; Q9H5Z9" "" "NF1 copy number variation syndrome" "1" "0" "1.180" "1.130" "1.021" "1.053" "1.135" "1.214" "1.090" "1.138" "1.107" "92.2" "108.8" "104.2" "94.1" "97.1" "104.6" "112.0" "100.5" "104.9" "102.0" "" "" "" "" "" "" "" "" "" "" "74.1" "78.5" "82.8" "63.1" "67.2" "78.5" "78.4" "73.4" "104.9" "83.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2021279172445188464" "False" "High" "IsMasterProtein" "Q9Y4E5" "E3 SUMO-protein ligase ZNF451 OS=Homo sapiens OX=9606 GN=ZNF451 PE=1 SV=2" "0.001" "False" "3.674" "1" "1" "1" "1" "1061" "121.4" "6.77" "3.37" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf18479" "26036" "ENSG00000112200" "ZNF451" "hsa:26036; Q5VVE9; Q5VVF1; Q86YE4; Q8N380; Q8TD15; Q9C0G1; Q9NQM1; Q9Y4E5" "" "" "0" "0" "0.958" "1.024" "1.122" "1.185" "1.259" "1.096" "0.875" "1.199" "1.209" "35.3" "33.8" "36.1" "39.6" "41.8" "44.4" "38.7" "30.9" "42.3" "42.6" "" "" "" "" "" "" "" "" "" "" "28.3" "24.4" "28.7" "26.5" "28.9" "33.3" "27.1" "22.6" "42.3" "34.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6333685787667816615" "False" "High" "IsMasterProtein" "Q5T011" "KICSTOR complex protein SZT2 OS=Homo sapiens OX=9606 GN=SZT2 PE=1 SV=3" "0.001" "False" "3.670" "1" "2" "2" "2" "3432" "377.8" "6.27" "4.68" "2" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "" "23334" "ENSG00000198198" "SZT2" "A0PJK5; A7E2X4; hsa:23334; O75055; Q5JUY7; Q5T011; Q5T012; Q5XKC7; Q6ZNI8; Q6ZT24; Q7Z636; Q8NAY9; Q9H5H7; Q9UFQ8" "Amino acids regulate mTORC1" "" "1" "0" "0.955" "0.807" "0.996" "1.213" "1.046" "0.951" "1.031" "1.077" "1.079" "48.1" "45.9" "38.8" "47.9" "58.4" "50.3" "45.7" "49.6" "51.8" "51.9" "" "" "" "" "" "" "" "" "" "" "38.6" "33.2" "30.8" "32.1" "40.4" "37.8" "32.0" "36.2" "51.8" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2153846373237469849" "False" "High" "IsMasterProtein" "Q5VV42" "Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Homo sapiens OX=9606 GN=CDKAL1 PE=1 SV=1" "0.001" "False" "3.664" "2" "1" "1" "1" "579" "65.1" "7.46" "2.37" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00919, Pf01938, Pf04055" "54901" "ENSG00000145996" "CDKAL1" "A8K6S0; hsa:54901; Q5VV42; Q6P385; Q6ZR27; Q9NXB3" "tRNA modification in the nucleus and cytosol" "Vitamin D receptor pathway" "2" "0" "0.727" "0.440" "0.659" "0.627" "0.566" "0.674" "0.706" "0.644" "0.616" "35.2" "25.6" "15.5" "23.2" "22.1" "19.9" "23.7" "24.8" "22.7" "21.7" "" "" "" "" "" "" "" "" "" "" "28.3" "18.5" "12.3" "15.5" "15.3" "14.9" "16.6" "18.1" "22.7" "17.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3216762708121930784" "False" "High" "IsMasterProtein" "Q75N03" "E3 ubiquitin-protein ligase Hakai OS=Homo sapiens OX=9606 GN=CBLL1 PE=1 SV=1" "0.001" "False" "3.650" "7" "2" "2" "2" "491" "54.5" "8.29" "1.92" "2" "cell adhesion;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf18408" "79872" "ENSG00000105879" "CBLL1" "B7ZM03; Q75N03; Q8TAJ4; Q9H5S6" "InlA-mediated entry of Listeria monocytogenes into host cells" "" "1" "0" "1.123" "1.024" "1.131" "1.105" "0.977" "1.021" "1.024" "1.036" "0.995" "300.7" "337.8" "307.8" "340.0" "332.2" "293.9" "306.9" "307.9" "311.7" "299.1" "" "" "" "" "" "" "" "" "" "" "241.5" "243.8" "244.5" "227.8" "229.7" "220.5" "214.9" "224.9" "311.7" "243.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241186879888904584" "False" "High" "IsMasterProtein" "Q2YD98" "UV-stimulated scaffold protein A OS=Homo sapiens OX=9606 GN=UVSSA PE=1 SV=2" "0.001" "False" "3.645" "2" "1" "1" "1" "709" "80.5" "6.30" "2.16" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09740, Pf20867" "57654" "ENSG00000163945" "UVSSA" "A8K9E6; B2RU11; hsa:57654; Q2YD98; Q8WTX4; Q9P1Z8" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "Nucleotide excision repair in xeroderma pigmentosum ; 10q11.21q11.23 copy number variation syndrome" "6" "0" "0.941" "1.000" "1.261" "0.960" "1.189" "0.980" "1.100" "1.000" "1.222" "29.2" "27.5" "29.2" "36.9" "28.1" "34.8" "28.7" "32.2" "29.2" "35.7" "" "" "" "" "" "" "" "" "" "" "23.5" "19.9" "23.2" "24.7" "19.4" "26.1" "20.1" "23.5" "29.2" "29.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8247855334061398620" "False" "High" "IsMasterProtein" "Q9H4K7" "Mitochondrial ribosome-associated GTPase 2 OS=Homo sapiens OX=9606 GN=MTG2 PE=1 SV=1" "0.001" "False" "3.641" "5" "2" "2" "2" "406" "43.9" "9.45" "4.13" "2" "other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01018, Pf01926" "26164" "ENSG00000101181" "MTG2" "A6NDR3; B4DR85; hsa:26164; Q96I17; Q9H4K7; Q9NVG9; Q9UFR4" "" "" "0" "0" "1.237" "1.110" "0.905" "1.119" "1.077" "1.158" "1.112" "1.162" "1.328" "57.5" "71.2" "63.9" "52.1" "64.4" "62.0" "66.6" "64.0" "66.9" "76.4" "" "" "" "" "" "" "" "" "" "" "46.2" "51.4" "50.7" "34.9" "44.5" "46.5" "46.7" "46.8" "66.9" "62.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1475037397769826540" "False" "High" "IsMasterProtein" "O75817" "Ribonuclease P protein subunit p20 OS=Homo sapiens OX=9606 GN=POP7 PE=1 SV=2" "0.001" "False" "3.610" "14" "1" "1" "1" "140" "15.6" "8.94" "2.74" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12328" "10248" "ENSG00000172336" "POP7" "A4D2E0; hsa:10248; O75817; Q9BV74" "tRNA processing in the nucleus" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3323196945052743606" "False" "High" "IsMasterProtein" "Q9UGC7" "Peptide chain release factor 1-like, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1L PE=1 SV=1" "0.001" "False" "3.607" "4" "1" "2" "1" "380" "43.6" "8.34" "6.18" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf00472, Pf03462" "54516" "ENSG00000112031" "MTRF1L" "B3KTA0; hsa:54516; Q3KR06; Q5TF44; Q5TF50; Q96CC5; Q96EX4; Q96K40; Q9UGC7" "Mitochondrial translation termination" "" "1" "0" "0.958" "1.928" "1.224" "1.072" "0.697" "9.400" "0.710" "2.660" "2.447" "182.0" "174.3" "350.7" "222.6" "195.1" "126.8" "1710.4" "129.2" "484.0" "445.2" "" "" "" "" "" "" "" "" "" "" "146.2" "125.8" "278.6" "149.2" "135.0" "95.1" "1197.5" "94.3" "484.0" "362.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1286687120538728620" "False" "High" "IsMasterProtein" "O94850" "Dendrin OS=Homo sapiens OX=9606 GN=DDN PE=1 SV=3" "0.001" "False" "3.602" "2" "1" "1" "1" "711" "76.0" "10.17" "2.75" "1" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15498" "23109" "ENSG00000181418" "DDN" "hsa:23109; O94850" "" "" "0" "0" "0.618" "1.336" "0.949" "0.958" "1.054" "1.139" "1.002" "1.031" "0.868" "20.5" "12.7" "27.4" "19.5" "19.7" "21.6" "23.3" "20.6" "21.1" "17.8" "" "" "" "" "" "" "" "" "" "" "16.5" "9.1" "21.8" "13.0" "13.6" "16.2" "16.3" "15.0" "21.1" "14.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4075227655953047173" "False" "High" "IsMasterProtein" "Q8IV61" "Ras guanyl-releasing protein 3 OS=Homo sapiens OX=9606 GN=RASGRP3 PE=1 SV=1" "0.001" "False" "3.590" "1" "1" "1" "1" "690" "78.3" "6.80" "3.32" "1" "signal transduction" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00130, Pf00617" "25780" "ENSG00000152689" "RASGRP3" "D6W583; hsa:25780; O94931; Q53SD7; Q8IV61" "RAF/MAP kinase cascade; Activation of RAS in B cells" "B cell receptor signaling pathway; MAPK signaling pathway; Ras signaling" "5" "0" "0.966" "0.854" "1.118" "1.123" "1.009" "0.910" "0.970" "0.842" "0.974" "144.4" "139.5" "123.4" "161.5" "162.2" "145.6" "131.4" "140.0" "121.6" "140.6" "" "" "" "" "" "" "" "" "" "" "116.0" "100.6" "98.0" "108.2" "112.2" "109.3" "92.0" "102.3" "121.6" "114.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895404278384693276" "False" "High" "IsMasterProtein" "P08047" "Transcription factor Sp1 OS=Homo sapiens OX=9606 GN=SP1 PE=1 SV=3" "0.001" "False" "3.587" "1" "1" "1" "1" "785" "80.6" "7.34" "3.25" "1" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6667" "ENSG00000185591" "SP1" "E4Z9M7; G5E9M8; hsa:6667; P08047; Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7" "PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP); SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Regulation of CDH11 gene transcription; NFE2L2 regulating tumorigenic genes" "Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; IL-17 signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Pathways in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "42" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7631275638739704783" "False" "High" "IsMasterProtein" "O95158" "Neurexophilin-4 OS=Homo sapiens OX=9606 GN=NXPH4 PE=1 SV=3" "0.001" "False" "3.572" "3" "1" "1" "1" "308" "33.0" "9.86" "2.79" "1" "signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf06312" "11247" "ENSG00000182379" "NXPH4" "A8K4I4; hsa:11247; O95158; Q7Z6L3; Q8N462" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463196673493200714" "False" "High" "IsMasterProtein" "P01116" "GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS PE=1 SV=1" "0.001" "False" "3.560" "6" "1" "1" "1" "189" "21.6" "6.77" "2.21" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00071" "3845" "ENSG00000133703" "KRAS" "A8K8Z5; B0LPF9; hsa:3845; P01116; P01118; Q96D10" "Signaling by CSF3 (G-CSF); Signaling by CSF1 (M-CSF) in myeloid cells; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants; RUNX3 regulates p14-ARF" "IL-5 signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; MAPK pathway in congenital thyroid cancer; Regulation of actin cytoskeleton; Alzheimer's disease; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "60" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8041398226355410347" "False" "High" "IsMasterProtein" "Q9NUL5" "Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2" "0.001" "False" "3.558" "6" "2" "2" "2" "291" "33.1" "7.25" "4.97" "2" "stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf15135" "55337" "ENSG00000130813" "SHFL" "A8MQT9; hsa:55337; Q4G188; Q8IYH6; Q8N8V1; Q9NUL5" "" "" "0" "0" "0.944" "0.869" "1.127" "0.941" "0.724" "1.119" "1.158" "1.187" "1.016" "27.1" "25.6" "23.6" "30.6" "25.5" "19.7" "30.4" "31.4" "32.2" "27.6" "" "" "" "" "" "" "" "" "" "" "21.8" "18.5" "18.7" "20.5" "17.7" "14.7" "21.3" "23.0" "32.2" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634393773107864734" "False" "High" "IsMasterProtein" "P19474" "E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1" "0.001" "False" "3.555" "2" "1" "1" "1" "475" "54.1" "6.38" "2.83" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00622, Pf00643, Pf13765" "6737" "ENSG00000132109" "TRIM21" "hsa:6737; P19474; Q5XPV5; Q96RF8" "Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA; STING mediated induction of host immune responses" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692621720317266464" "False" "High" "IsMasterProtein" "P17098" "Zinc finger protein 8 OS=Homo sapiens OX=9606 GN=ZNF8 PE=1 SV=2" "0.001" "False" "3.555" "4" "2" "2" "2" "575" "64.9" "7.39" "4.21" "2" "signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "7554" "ENSG00000278129" "ZNF8" "hsa:7554; P17098; Q6PI99" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8399686422006739058" "False" "High" "IsMasterProtein" "O15116" "U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1" "0.001" "False" "3.543" "11" "2" "2" "2" "133" "15.2" "5.22" "4.70" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27257" "ENSG00000175324" "LSM1" "B2R5E6; hsa:27257; O15116" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "0.962" "1.143" "0.754" "0.998" "1.148" "0.967" "1.199" "0.869" "1.057" "106.4" "102.3" "121.6" "80.2" "106.2" "122.1" "102.8" "127.6" "92.4" "112.5" "" "" "" "" "" "" "" "" "" "" "85.4" "73.8" "96.6" "53.7" "73.4" "91.6" "72.0" "93.2" "92.4" "91.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1970513305898255231" "False" "High" "IsMasterProtein" "Q9H2D6" "TRIO and F-actin-binding protein OS=Homo sapiens OX=9606 GN=TRIOBP PE=1 SV=3" "0.001" "False" "3.542" "0" "1" "1" "1" "2365" "261.2" "8.48" "3.41" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169" "11078" "ENSG00000100106" "TRIOBP" "B1AHD4; B1AHD7; F2Z2W0; F8W6V6; hsa:11078; O94797; Q2PZW8; Q2Q3Z9; Q2Q400; Q5R3M6; Q96DW1; Q9BT77; Q9BTL7; Q9BY98; Q9H2D6; Q9Y3L4" "" "" "0" "0" "0.975" "1.055" "1.057" "1.048" "1.088" "1.232" "1.164" "1.065" "0.948" "172.3" "168.0" "181.8" "182.1" "180.5" "187.5" "212.3" "200.6" "183.5" "163.4" "" "" "" "" "" "" "" "" "" "" "138.4" "121.2" "144.4" "122.0" "124.9" "140.7" "148.6" "146.5" "183.5" "132.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9086652691068798717" "False" "High" "IsMasterProtein" "P51970" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Homo sapiens OX=9606 GN=NDUFA8 PE=1 SV=3" "0.001" "False" "3.540" "9" "2" "2" "2" "172" "20.1" "7.65" "4.73" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf06747" "4702" "ENSG00000119421" "NDUFA8" "B1AM93; hsa:4702; P51970; Q9Y6N0" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.865" "0.954" "1.124" "0.937" "1.001" "0.950" "0.826" "1.071" "0.881" "30.0" "25.9" "28.6" "33.7" "28.1" "30.0" "28.5" "24.7" "32.1" "26.4" "" "" "" "" "" "" "" "" "" "" "24.1" "18.7" "22.7" "22.5" "19.4" "22.5" "19.9" "18.1" "32.1" "21.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-591138811346724328" "False" "High" "IsMasterProtein" "O15055" "Period circadian protein homolog 2 OS=Homo sapiens OX=9606 GN=PER2 PE=1 SV=2" "0.001" "False" "3.533" "1" "1" "1" "1" "1255" "136.5" "6.47" "2.79" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08447, Pf12114, Pf21353" "8864" "ENSG00000132326" "PER2" "A2I2P7; hsa:8864; O15055; Q4ZG49; Q6DT41; Q9UQ45" "Circadian Clock" "Melatonin metabolism and effects; Exercise-induced circadian regulation; Orexin receptor pathway; 2q37 copy number variation syndrome; Acute myeloid leukemia" "6" "0" "0.874" "1.077" "0.769" "0.996" "0.945" "0.822" "0.801" "0.677" "0.587" "20.9" "18.3" "22.5" "16.1" "20.8" "19.8" "17.2" "16.7" "14.2" "12.3" "" "" "" "" "" "" "" "" "" "" "16.8" "13.2" "17.9" "10.8" "14.4" "14.8" "12.0" "12.2" "14.2" "10.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904247061824975509" "False" "High" "IsMasterProtein" "Q9NP73" "UDP-N-acetylglucosamine transferase subunit ALG13 OS=Homo sapiens OX=9606 GN=ALG13 PE=1 SV=2" "0.001" "False" "3.515" "2" "1" "1" "1" "1137" "126.0" "6.74" "2.37" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02338, Pf04101" "79868" "ENSG00000101901" "ALG13" "B1AKD6; B1AKM1; B2R5L5; B7Z6J0; B7Z804; B7Z847; B7Z9A8; B7ZAJ1; B7ZB57; hsa:79868; Q17RC3; Q5JXY9; Q9H5U8; Q9NP73" "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS" "N-glycan biosynthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875148632163355861" "False" "High" "IsMasterProtein" "Q9Y3D2" "Methionine-R-sulfoxide reductase B2, mitochondrial OS=Homo sapiens OX=9606 GN=MSRB2 PE=1 SV=2" "0.001" "False" "3.513" "5" "1" "1" "1" "182" "19.5" "8.63" "3.09" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01641" "22921" "ENSG00000148450" "MSRB2" "hsa:22921; Q17R44; Q4G1C7; Q9Y3D2; Q9Y5W6" "Protein repair" "Sulindac metabolic pathway; Methionine de novo and salvage pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6338677437993936073" "False" "High" "IsMasterProtein" "P30305" "M-phase inducer phosphatase 2 OS=Homo sapiens OX=9606 GN=CDC25B PE=1 SV=2" "0.001" "False" "3.513" "2" "1" "1" "1" "580" "64.9" "6.40" "2.20" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00581, Pf06617" "994" "ENSG00000101224" "CDC25B" "D3DVY1; D3DVY2; D3DVY3; D3DVY4; hsa:994; O43551; P30305; Q13971; Q5JX77; Q6RSS1; Q9BRA6" "Cyclin A/B1/B2 associated events during G2/M transition; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; Retinoblastoma gene in cancer; MAPK signaling pathway" "8" "0" "0.817" "0.923" "1.017" "0.991" "0.919" "0.886" "0.958" "1.402" "0.849" "29.2" "23.9" "27.0" "29.7" "28.9" "26.8" "25.9" "28.0" "40.9" "24.8" "" "" "" "" "" "" "" "" "" "" "23.5" "17.2" "21.4" "19.9" "20.0" "20.1" "18.1" "20.4" "40.9" "20.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3215128447752590217" "False" "High" "IsMasterProtein" "A2RUS2" "DENN domain-containing protein 3 OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=2" "0.001" "False" "3.497" "1" "2" "2" "2" "1198" "135.8" "7.06" "4.81" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02141, Pf03456" "22898" "ENSG00000105339" "DENND3" "A2RUS2; B7ZM28; hsa:22898; O94947; Q2TAM7; Q6ZMS6; Q96DK3" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1162437005396674229" "False" "High" "IsMasterProtein" "Q99442" "Translocation protein SEC62 OS=Homo sapiens OX=9606 GN=SEC62 PE=1 SV=1" "0.001" "False" "3.495" "2" "1" "1" "1" "399" "45.8" "7.12" "3.32" "1" "transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf03839" "7095" "ENSG00000008952" "SEC62" "D3DNQ0; hsa:7095; O00682; O00729; Q99442" "" "" "0" "0" "1.053" "0.946" "1.122" "0.928" "1.001" "1.004" "0.869" "1.100" "1.083" "106.1" "111.7" "100.3" "119.0" "98.5" "106.2" "106.5" "92.2" "116.7" "114.9" "" "" "" "" "" "" "" "" "" "" "85.2" "80.6" "79.7" "79.8" "68.1" "79.7" "74.6" "67.4" "116.7" "93.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5795480292757374636" "False" "High" "IsMasterProtein" "Q6PJ61" "F-box only protein 46 OS=Homo sapiens OX=9606 GN=FBXO46 PE=1 SV=3" "0.001" "False" "3.492" "2" "1" "1" "1" "603" "64.6" "7.40" "4.31" "1" "" "" "" "Pf12937" "23403" "ENSG00000177051" "FBXO46" "hsa:23403; Q6PJ61" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002745852381012675" "False" "High" "IsMasterProtein" "P13056" "Nuclear receptor subfamily 2 group C member 1 OS=Homo sapiens OX=9606 GN=NR2C1 PE=1 SV=2" "0.001" "False" "3.481" "3" "1" "1" "1" "603" "67.3" "6.32" "3.62" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7181" "ENSG00000120798" "NR2C1" "A8K5K4; hsa:7181; P13056; Q15625; Q15626" "Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7091276917323746637" "False" "High" "IsMasterProtein" "Q9H008" "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase OS=Homo sapiens OX=9606 GN=LHPP PE=1 SV=2" "0.001" "False" "3.480" "3" "1" "1" "1" "270" "29.1" "6.15" "3.39" "1" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf13242, Pf13344" "64077" "ENSG00000107902" "LHPP" "B3KP20; hsa:64077; Q2TBE9; Q5VUV9; Q5VUW0; Q9H008" "Pyrophosphate hydrolysis" "" "1" "0" "1.077" "1.050" "1.081" "0.928" "1.014" "0.847" "0.867" "1.063" "0.969" "149.6" "161.1" "157.1" "161.7" "138.9" "151.8" "126.7" "129.8" "159.1" "145.0" "" "" "" "" "" "" "" "" "" "" "120.2" "116.2" "124.8" "108.3" "96.1" "113.9" "88.7" "94.8" "159.1" "117.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4099473831415028291" "False" "High" "IsMasterProtein" "Q15011" "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein OS=Homo sapiens OX=9606 GN=HERPUD1 PE=1 SV=1" "0.001" "False" "3.479" "5" "2" "2" "1" "391" "43.7" "5.25" "2.55" "2" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00240" "9709" "ENSG00000051108" "HERPUD1" "E9PGD1; hsa:9709; O60644; Q15011; Q6IAN8; Q96D92" "ATF4 activates genes in response to endoplasmic reticulum stress" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643630707960143102" "False" "High" "IsMasterProtein" "Q4KWH8" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" "0.001" "False" "3.468" "0" "1" "3" "1" "1693" "189.1" "7.74" "10.88" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23007" "ENSG00000114805" "PLCH1" "hsa:23007; Q29RV9; Q4KWH8; Q4KWH9; Q68CN0; Q86XK4; Q9H9U2; Q9UPT3" "Synthesis of IP3 and IP4 in the cytosol" "Mesodermal commitment pathway; GPR40 pathway" "3" "0" "1.058" "1.063" "0.930" "1.073" "1.068" "0.876" "1.081" "1.060" "0.992" "531.9" "562.6" "565.2" "494.8" "570.5" "568.1" "466.1" "574.8" "563.7" "527.6" "" "" "" "" "" "" "" "" "" "" "427.2" "405.9" "449.0" "331.5" "394.6" "426.2" "326.3" "419.8" "563.7" "429.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6798744220953383884" "False" "High" "IsMasterProtein" "P35568" "Insulin receptor substrate 1 OS=Homo sapiens OX=9606 GN=IRS1 PE=1 SV=1" "0.001" "False" "3.459" "1" "1" "1" "1" "1242" "131.5" "8.54" "2.50" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf02174" "3667" "ENSG00000169047" "IRS1" "hsa:3667; P35568" "RAF/MAP kinase cascade; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by ALK; Growth hormone receptor signaling; Signaling by Leptin; SOS-mediated signalling; IRS activation; Signal attenuation; Activated NTRK3 signals through PI3K" "Type II diabetes mellitus; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Transcription factor regulation in adipogenesis; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Nonalcoholic fatty liver disease; Gastrin signaling pathway; Insulin signaling; FOXA2 pathway; Neuroinflammation and glutamatergic signaling; Congenital generalized lipodystrophy; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways; DNA damage response (only ATM dependent)" "44" "0" "1.008" "1.140" "1.211" "0.800" "0.869" "1.497" "1.257" "1.148" "1.207" "17.9" "18.0" "20.4" "21.6" "14.3" "15.5" "26.7" "22.4" "20.5" "21.5" "" "" "" "" "" "" "" "" "" "" "14.3" "13.0" "16.2" "14.5" "9.9" "11.6" "18.7" "16.4" "20.5" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009028340265945261" "False" "High" "IsMasterProtein" "Q5QJE6" "Deoxynucleotidyltransferase terminal-interacting protein 2 OS=Homo sapiens OX=9606 GN=DNTTIP2 PE=1 SV=2" "0.001" "False" "3.439" "2" "1" "1" "1" "756" "84.4" "6.16" "1.77" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf08698" "30836" "ENSG00000067334" "DNTTIP2" "hsa:30836; Q12987; Q53H59; Q5QJE6; Q5TFJ4; Q6TLI0; Q76MJ8; Q86WX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2820627768769549647" "False" "High" "IsMasterProtein" "P51571" "Translocon-associated protein subunit delta OS=Homo sapiens OX=9606 GN=SSR4 PE=1 SV=1" "0.001" "False" "3.438" "6" "1" "1" "1" "173" "19.0" "6.15" "3.23" "1" "" "other membranes;ER/Golgi;other cell component" "" "Pf05404" "6748" "ENSG00000180879" "SSR4" "A8K378; hsa:6748; P51571; Q53XY1" "SRP-dependent cotranslational protein targeting to membrane" "VEGFA-VEGFR2 signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6571071577836756123" "False" "High" "IsMasterProtein" "Q9NUP1" "Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1" "0.001" "False" "3.431" "6" "1" "1" "1" "217" "23.3" "4.98" "3.70" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;other cell component" "" "" "55330" "ENSG00000186222" "BLOC1S4" "hsa:55330; Q6NVY6; Q96G84; Q9NUP1" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6336479457055724127" "False" "High" "IsMasterProtein" "Q9UQ84" "Exonuclease 1 OS=Homo sapiens OX=9606 GN=EXO1 PE=1 SV=2" "0.001" "False" "3.426" "2" "1" "1" "1" "846" "94.0" "8.31" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "9156" "ENSG00000174371" "EXO1" "hsa:9156; O60545; O75214; O75466; Q5T396; Q96IJ1; Q9UG38; Q9UNW0; Q9UQ84" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "DNA repair pathways, full network; DNA mismatch repair; Primary ovarian insufficiency" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3780943028693763467" "False" "High" "IsMasterProtein" "Q9H009" "Nascent polypeptide-associated complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=NACA2 PE=1 SV=1" "0.001" "False" "3.420" "4" "1" "1" "1" "215" "23.2" "4.73" "3.91" "1" "other biological processes" "translational apparatus;nucleus;other cell component" "other molecular function" "Pf01849, Pf19026" "342538" "ENSG00000253506" "NACA2" "hsa:342538; Q2VIR9; Q9H009" "" "" "0" "0" "0.867" "0.811" "1.068" "0.925" "0.861" "0.907" "1.003" "0.860" "0.857" "268.3" "232.5" "217.5" "286.4" "248.1" "231.0" "243.5" "269.0" "230.6" "230.0" "" "" "" "" "" "" "" "" "" "" "215.5" "167.8" "172.8" "191.9" "171.6" "173.3" "170.5" "196.4" "230.6" "187.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6471377721056749589" "False" "High" "IsMasterProtein" "Cont_Q58D62" "Fetuin-B OS=Bos taurus OX=9913 GN=FETUB PE=1 SV=1" "0.001" "True" "3.414" "5" "2" "2" "2" "387" "42.6" "5.77" "4.06" "2" "other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00031" "504615" "ENSBTAG00000017531" "FETUB" "bta:504615; Q58D62" "" "" "0" "0" "1.302" "0.878" "1.365" "1.168" "1.065" "1.442" "1.176" "1.024" "1.251" "107.4" "139.8" "94.2" "146.5" "125.4" "114.3" "154.9" "126.2" "109.9" "134.4" "" "" "" "" "" "" "" "" "" "" "86.2" "100.9" "74.9" "98.2" "86.8" "85.8" "108.4" "92.2" "109.9" "109.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4139945587606400296" "False" "High" "IsMasterProtein" "Q07352" "mRNA decay activator protein ZFP36L1 OS=Homo sapiens OX=9606 GN=ZFP36L1 PE=1 SV=1" "0.001" "False" "3.412" "2" "1" "1" "1" "338" "36.3" "7.96" "3.58" "1" "cell adhesion;cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "677" "ENSG00000185650" "ZFP36L1" "hsa:677; Q07352; Q13851" "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "Modulators of TCR signaling and T cell activation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6926714013123619356" "False" "High" "IsMasterProtein" "Q92610" "Zinc finger protein 592 OS=Homo sapiens OX=9606 GN=ZNF592 PE=1 SV=2" "0.001" "False" "3.406" "1" "2" "2" "2" "1267" "137.4" "7.84" "2.53" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf16622" "9640" "ENSG00000166716" "ZNF592" "hsa:9640; Q2M1T2; Q504Y9; Q92610" "" "15q25 copy number variation" "1" "0" "0.865" "1.109" "1.118" "0.924" "1.118" "0.954" "0.735" "0.883" "0.904" "26.1" "22.5" "28.9" "29.1" "24.1" "29.1" "24.9" "19.2" "23.0" "23.6" "" "" "" "" "" "" "" "" "" "" "20.9" "16.3" "23.0" "19.5" "16.7" "21.9" "17.4" "14.0" "23.0" "19.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8448471456180421378" "False" "High" "IsMasterProtein" "Q9P275" "Ubiquitin carboxyl-terminal hydrolase 36 OS=Homo sapiens OX=9606 GN=USP36 PE=1 SV=4" "0.001" "False" "3.405" "1" "1" "1" "1" "1123" "122.8" "9.70" "3.59" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57602" "ENSG00000055483" "USP36" "hsa:57602; Q05C98; Q05DD0; Q6IQ38; Q8NDM8; Q9NVC8; Q9P275" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8308098162091445686" "False" "High" "IsMasterProtein" "Q9P0N9" "TBC1 domain family member 7 OS=Homo sapiens OX=9606 GN=TBC1D7 PE=1 SV=1" "0.001" "False" "3.399" "3" "1" "1" "1" "293" "34.0" "7.94" "3.34" "1" "stress response;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "107080638; 51256" "ENSG00000145979" "TBC1D7" "E7EV96; hsa:107080638; hsa:51256; Q2TU37; Q53F44; Q5SZL7; Q86VM8; Q96MB8; Q9P0N9" "TBC/RABGAPs" "Fragile X syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-251433897532185408" "False" "High" "IsMasterProtein" "Q9H3H1" "tRNA dimethylallyltransferase OS=Homo sapiens OX=9606 GN=TRIT1 PE=1 SV=1" "0.001" "False" "3.396" "2" "1" "1" "1" "467" "52.7" "8.21" "2.84" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01715" "54802" "ENSG00000043514" "TRIT1" "A1A4X7; hsa:54802; Q3T7B5; Q5QPK5; Q5QPK6; Q6IAC9; Q96FJ3; Q96L45; Q9H3H1; Q9NXT7" "tRNA modification in the nucleus and cytosol; tRNA modification in the mitochondrion" "" "2" "0" "1.052" "1.067" "1.183" "0.850" "0.845" "0.751" "0.974" "0.993" "1.228" "52.1" "54.8" "55.6" "61.6" "44.2" "44.0" "39.1" "50.7" "51.7" "63.9" "" "" "" "" "" "" "" "" "" "" "41.8" "39.5" "44.1" "41.3" "30.6" "33.0" "27.4" "37.0" "51.7" "52.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4105877346039324927" "False" "High" "IsMasterProtein" "Q9BV29" "Coiled-coil domain-containing protein 32 OS=Homo sapiens OX=9606 GN=CCDC32 PE=1 SV=2" "0.001" "False" "3.386" "5" "1" "1" "1" "185" "20.6" "4.53" "4.06" "1" "cell organization and biogenesis;other biological processes" "other membranes" "" "Pf14989" "90416" "ENSG00000128891" "CCDC32" "A8KAL4; Q86TC4; Q8N788; Q8NAR7; Q9BV29" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6949912149279569323" "False" "High" "IsMasterProtein" "Q9BS16" "Centromere protein K OS=Homo sapiens OX=9606 GN=CENPK PE=1 SV=1" "0.001" "False" "3.377" "4" "1" "1" "1" "269" "31.6" "4.89" "2.59" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf11802" "64105" "ENSG00000123219" "CENPK" "hsa:64105; Q9BS16; Q9H4L0" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8745389805375581361" "False" "High" "IsMasterProtein" "P24539" "ATP synthase F(0) complex subunit B1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PB PE=1 SV=2" "0.001" "False" "3.376" "3" "1" "1" "1" "256" "28.9" "9.36" "3.39" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05405" "515" "ENSG00000116459" "ATP5PB" "hsa:515; P24539; Q9BQ68; Q9BRU8" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1734934898581359440" "False" "High" "IsMasterProtein" "P61457" "Pterin-4-alpha-carbinolamine dehydratase OS=Homo sapiens OX=9606 GN=PCBD1 PE=1 SV=2" "0.001" "False" "3.367" "14" "2" "2" "1" "104" "12.0" "6.80" "6.06" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01329" "5092" "ENSG00000166228" "PCBD1" "hsa:5092; P61457; P70519; P80095; Q9D930" "Phenylalanine metabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4099103662110185134" "False" "High" "IsMasterProtein" "Q08722" "Leukocyte surface antigen CD47 OS=Homo sapiens OX=9606 GN=CD47 PE=1 SV=1" "0.001" "False" "3.365" "2" "1" "1" "1" "323" "35.2" "7.21" "4.07" "1" "cell adhesion;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf04549, Pf08204" "961" "ENSG00000196776" "CD47" "A8K198; D3DN59; hsa:961; Q08722; Q53Y71; Q96A60" "Neutrophil degranulation; Integrin cell surface interactions; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions" "Spinal cord injury; Pleural mesothelioma" "6" "0" "0.935" "0.870" "0.919" "1.128" "0.965" "1.165" "0.911" "1.055" "1.076" "319.8" "299.0" "278.3" "294.1" "360.6" "308.7" "372.7" "291.4" "337.6" "344.2" "" "" "" "" "" "" "" "" "" "" "256.9" "215.7" "221.0" "197.0" "249.4" "231.6" "260.9" "212.8" "337.6" "279.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157929292758815644" "False" "High" "IsMasterProtein" "Q96A35" "Large ribosomal subunit protein uL24m OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" "0.001" "False" "3.364" "6" "1" "1" "1" "216" "24.9" "9.29" "3.75" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf17136" "79590" "ENSG00000143314" "MRPL24" "D3DVC8; hsa:79590; Q53G65; Q53HT0; Q5SYZ9; Q5SZ00; Q5SZ02; Q96A35; Q96Q70; Q9H7G3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7089722272324942505" "False" "High" "IsMasterProtein" "Q9NU23" "LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1" "0.001" "False" "3.362" "9" "1" "1" "1" "88" "10.4" "10.46" "3.22" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf05347" "57226" "ENSG00000083099" "LYRM2" "B2R4U2; E1P517; hsa:57226; Q9NU23" "" "" "0" "0" "1.098" "1.156" "1.225" "0.934" "1.138" "1.038" "1.016" "0.929" "1.122" "168.7" "185.3" "195.0" "206.7" "157.6" "192.0" "175.0" "171.3" "156.8" "189.3" "" "" "" "" "" "" "" "" "" "" "135.5" "133.7" "154.9" "138.5" "109.0" "144.0" "122.5" "125.1" "156.8" "153.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3691090388992879642" "False" "High" "IsMasterProtein" "Cont_P02453" "Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3" "0.001" "True" "3.362" "1" "1" "1" "1" "1463" "138.9" "5.78" "2.60" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "extracellular structural activity;other molecular function" "Pf00093, Pf01391, Pf01410" "104990617; 109573749; 282187" "ENSBIXG00000001136; ENSBTAG00000013103" "COL1A1" "A0A4W2CI58; A0A6B0RVL7; A0A6P3HPH0; A0A6P5DEQ2; bbis:104990617; biu:109573749; bta:282187; P02453; Q3MHM2" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling" "Inflammatory response pathway; Osteoblast signaling; Focal adhesion" "19" "0" "0.417" "0.095" "0.178" "0.148" "0.124" "0.130" "0.134" "0.209" "0.269" "83.9" "35.0" "7.9" "14.9" "12.4" "10.4" "10.9" "11.2" "17.5" "22.6" "" "" "" "" "" "" "" "" "" "" "67.4" "25.3" "6.3" "10.0" "8.6" "7.8" "7.6" "8.2" "17.5" "18.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6709781459489319409" "False" "High" "IsMasterProtein" "Q9UHN1" "DNA polymerase subunit gamma-2 OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1" "0.001" "False" "3.361" "2" "1" "2" "1" "485" "54.9" "8.35" "5.97" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf03129" "11232" "ENSG00000256525" "POLG2" "hsa:11232; O00419; Q0IJ81; Q96GW2; Q9UHN1; Q9UK35; Q9UK94" "Transcriptional activation of mitochondrial biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6981567354116466271" "False" "High" "IsMasterProtein" "O43542" "DNA repair protein XRCC3 OS=Homo sapiens OX=9606 GN=XRCC3 PE=1 SV=1" "0.001" "False" "3.358" "5" "2" "2" "2" "346" "37.8" "8.48" "4.80" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7517" "ENSG00000126215" "XRCC3" "hsa:7517; O43542; O43568; Q9BU18" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange" "Fluoropyrimidine activity; Male infertility" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3370309329751245495" "False" "High" "IsMasterProtein" "Q96RQ9" "L-amino-acid oxidase OS=Homo sapiens OX=9606 GN=IL4I1 PE=1 SV=1" "0.001" "False" "3.356" "3" "1" "1" "1" "567" "62.8" "8.68" "0.00" "1" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01593" "259307" "ENSG00000104951" "IL4I1" "hsa:259307; Q1WMJ3; Q4GZN1; Q4GZN2; Q6P2Q3; Q8TEM5; Q96RQ8; Q96RQ9" "Phenylalanine metabolism" "Methionine de novo and salvage pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "High" "1" "" "-8635203665843226686" "False" "High" "IsMasterProtein" "P33947" "ER lumen protein-retaining receptor 2 OS=Homo sapiens OX=9606 GN=KDELR2 PE=1 SV=1" "0.001" "False" "3.352" "4" "1" "1" "1" "212" "24.4" "8.72" "3.21" "1" "transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00810" "11014" "ENSG00000136240" "KDELR2" "A4D2P4; hsa:11014; P33947; Q6IPC5; Q96E30" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "0.887" "0.934" "0.924" "0.922" "1.140" "0.942" "0.916" "0.988" "1.031" "160.8" "142.7" "150.2" "148.6" "148.3" "183.4" "151.5" "147.3" "158.8" "165.8" "" "" "" "" "" "" "" "" "" "" "129.2" "103.0" "119.3" "99.5" "102.6" "137.6" "106.0" "107.6" "158.8" "134.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9046713427756662077" "False" "High" "IsMasterProtein" "Q05209" "Tyrosine-protein phosphatase non-receptor type 12 OS=Homo sapiens OX=9606 GN=PTPN12 PE=1 SV=3" "0.002" "False" "3.332" "1" "1" "1" "1" "780" "88.1" "5.62" "3.63" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5782" "ENSG00000127947" "PTPN12" "A4D1C5; B4DKY2; E9PBR5; E9PEH9; hsa:5782; Q05209; Q16130; Q59FD6; Q75MN8; Q86XU4" "Signaling by PDGF; SHC1 events in ERBB2 signaling; Downregulation of ERBB2 signaling; EGFR downregulation; Interleukin-37 signaling; Constitutive Signaling by Overexpressed ERBB2" "EGF/EGFR signaling pathway" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8528548452001868396" "False" "High" "IsMasterProtein" "Q8NA72" "Centrosomal protein POC5 OS=Homo sapiens OX=9606 GN=POC5 PE=1 SV=2" "0.002" "False" "3.328" "2" "1" "1" "1" "575" "63.3" "7.42" "2.06" "1" "cell cycle OR cell proliferation" "cytosol;cytoskeleton;nucleus" "" "" "134359" "ENSG00000152359" "POC5" "B4DJG7; hsa:134359; Q494X7; Q494X9; Q6P085; Q8NA72" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887773767884950166" "False" "High" "IsMasterProtein" "Q68DK7" "Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3" "0.002" "False" "3.322" "1" "1" "1" "1" "614" "67.1" "8.92" "2.99" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275, Pf16801" "339287" "ENSG00000188895" "MSL1" "hsa:339287; Q0VF46; Q68DK7; Q69Z03" "HATs acetylate histones" "" "1" "0" "0.943" "0.898" "1.031" "0.915" "1.002" "0.916" "0.933" "1.001" "1.130" "146.6" "138.2" "131.7" "151.1" "134.0" "146.8" "134.2" "136.8" "146.8" "165.6" "" "" "" "" "" "" "" "" "" "" "117.7" "99.7" "104.6" "101.2" "92.7" "110.2" "94.0" "99.9" "146.8" "134.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1604052202135203910" "False" "High" "IsMasterProtein" "O00592" "Podocalyxin OS=Homo sapiens OX=9606 GN=PODXL PE=1 SV=2" "0.002" "False" "3.310" "2" "1" "1" "1" "558" "58.6" "5.49" "2.97" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06365" "5420" "ENSG00000128567" "PODXL" "A6NHX8; hsa:5420; O00592; Q52LZ7; Q53ER6" "" "Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Pleural mesothelioma" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7524617474399668793" "False" "High" "IsMasterProtein" "Q6DD88" "Atlastin-3 OS=Homo sapiens OX=9606 GN=ATL3 PE=1 SV=1" "0.002" "False" "3.308" "2" "1" "1" "1" "541" "60.5" "5.66" "2.54" "1" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf02263, Pf02841" "25923" "ENSG00000184743" "ATL3" "hsa:25923; Q6DD88; Q8N7W5; Q9H8Q5; Q9UFL1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-303633341198715328" "False" "High" "IsMasterProtein" "Q96PV6" "Leukocyte receptor cluster member 8 OS=Homo sapiens OX=9606 GN=LENG8 PE=1 SV=3" "0.002" "False" "3.298" "4" "2" "2" "2" "800" "88.1" "9.11" "0.00" "2" "" "nucleus;other cell component" "" "Pf03399" "114823" "ENSG00000167615; ENSG00000274305; ENSG00000276458; ENSG00000276681" "LENG8" "A0A087WTE7; B0VJY9; hsa:114823; Q8IZ27; Q8NCX6; Q96PV6" "" "" "0" "0" "1.032" "1.140" "1.202" "1.052" "1.101" "1.053" "1.048" "1.152" "1.152" "49.6" "51.2" "56.6" "59.6" "52.2" "54.6" "52.2" "52.0" "57.1" "57.2" "" "" "" "" "" "" "" "" "" "" "39.8" "37.0" "44.9" "40.0" "36.1" "41.0" "36.6" "38.0" "57.1" "46.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2882906632265539377" "False" "High" "IsMasterProtein" "Q9NQV6" "PR domain zinc finger protein 10 OS=Homo sapiens OX=9606 GN=PRDM10 PE=1 SV=3" "0.002" "False" "3.292" "1" "1" "1" "1" "1147" "130.1" "6.74" "3.50" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf21549" "56980" "ENSG00000170325" "PRDM10" "B7ZL71; G3XAE5; hsa:56980; J3KP23; Q17R90; Q2KHR4; Q863Z2; Q9NQV6; Q9NXI4; Q9ULI9" "" "" "0" "0" "1.501" "1.256" "1.496" "1.501" "1.354" "1.084" "1.331" "1.144" "1.406" "39.8" "59.8" "50.0" "59.6" "59.8" "53.9" "43.2" "53.0" "45.5" "56.0" "" "" "" "" "" "" "" "" "" "" "32.0" "43.1" "39.7" "39.9" "41.3" "40.5" "30.2" "38.7" "45.5" "45.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741603039625968059" "False" "High" "IsMasterProtein" "Q96T49" "Protein phosphatase 1 regulatory inhibitor subunit 16B OS=Homo sapiens OX=9606 GN=PPP1R16B PE=1 SV=1" "0.002" "False" "3.292" "2" "1" "1" "1" "567" "63.5" "6.49" "3.76" "1" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity" "Pf00023, Pf12796" "26051" "ENSG00000101445" "PPP1R16B" "A2RRR6; E9PFS8; hsa:26051; O94912; Q5W9G4; Q96T49; Q9NQG4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-499196435734005468" "False" "High" "IsMasterProtein" "Q96GJ1" "tRNA (uracil-5-)-methyltransferase homolog B OS=Homo sapiens OX=9606 GN=TRMT2B PE=1 SV=1" "0.002" "False" "3.291" "2" "1" "1" "1" "504" "56.4" "8.81" "3.09" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf05958" "79979" "ENSG00000188917" "TRMT2B" "A6NDG5; A6NEI9; A6NMG6; hsa:79979; Q5JPF0; Q5JVY6; Q96GJ1; Q96HU7; Q96IH9; Q9H9K2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4328558024401800768" "False" "High" "IsMasterProtein" "Q12913" "Receptor-type tyrosine-protein phosphatase eta OS=Homo sapiens OX=9606 GN=PTPRJ PE=1 SV=3" "0.002" "False" "3.281" "1" "1" "1" "1" "1337" "145.9" "5.58" "2.33" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf00102, Pf18861" "5795" "ENSG00000149177" "PTPRJ" "hsa:5795; Q12913; Q15255; Q6P4H4; Q8NHM2; Q9UDA9" "Negative regulation of FLT3; Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Negative regulation of MET activity" "VEGFA-VEGFR2 signaling" "5" "0" "1.329" "1.003" "1.253" "1.065" "1.220" "1.152" "1.062" "1.271" "1.139" "64.4" "85.6" "64.6" "80.8" "68.6" "78.6" "74.2" "68.5" "81.9" "73.4" "" "" "" "" "" "" "" "" "" "" "51.8" "61.8" "51.3" "54.1" "47.5" "59.0" "52.0" "50.0" "81.9" "59.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619952528215347024" "False" "High" "IsMasterProtein" "P09326" "CD48 antigen OS=Homo sapiens OX=9606 GN=CD48 PE=1 SV=2" "0.002" "False" "3.274" "5" "1" "1" "1" "243" "27.7" "8.07" "2.83" "1" "stress response" "plasma membrane;other membranes" "" "Pf07686, Pf13895" "962" "ENSG00000117091" "CD48" "hsa:962; P09326; Q5U055; Q8MGR0" "Cell surface interactions at the vascular wall" "Gastric cancer network 2" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5885254063310961994" "False" "High" "IsMasterProtein" "Q6NXT1" "Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2" "0.002" "False" "3.274" "3" "1" "1" "1" "300" "32.5" "6.28" "2.93" "1" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf12796" "129138" "ENSG00000100124" "ANKRD54" "hsa:129138; Q6NXT1; Q6ZSB1; Q9UGV1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428917072824426789" "False" "High" "IsMasterProtein" "Q8NDV7" "Trinucleotide repeat-containing gene 6A protein OS=Homo sapiens OX=9606 GN=TNRC6A PE=1 SV=2" "0.002" "False" "3.257" "1" "1" "1" "1" "1962" "210.2" "7.01" "2.88" "1" "stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf10427, Pf16608" "27327" "ENSG00000090905" "TNRC6A" "C9JAR8; hsa:27327; O15408; Q658L5; Q6NVB5; Q8NDV7; Q8NEZ0; Q8TBT8; Q8TCR0; Q9NV59; Q9P268" "MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; Ca2+ pathway; Transcriptional regulation by small RNAs; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-216819493062763362" "False" "High" "IsMasterProtein" "O00165" "HCLS1-associated protein X-1 OS=Homo sapiens OX=9606 GN=HAX1 PE=1 SV=2" "0.002" "False" "3.246" "3" "1" "1" "1" "279" "31.6" "4.92" "2.36" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "" "10456" "ENSG00000143575" "HAX1" "A8W4W9; A8W4X0; B4DUJ7; hsa:10456; O00165; Q5VYD5; Q5VYD7; Q96AU4; Q9BS80" "" "Primary ovarian insufficiency" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1421491913657631264" "False" "High" "IsMasterProtein" "P13765" "HLA class II histocompatibility antigen, DO beta chain OS=Homo sapiens OX=9606 GN=HLA-DOB PE=1 SV=1" "0.002" "False" "3.238" "4" "1" "1" "1" "273" "30.8" "6.79" "4.04" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3112" "ENSG00000239457; ENSG00000241106; ENSG00000241386; ENSG00000241910; ENSG00000243496; ENSG00000243612" "HLA-DOB" "B0V0Y0; hsa:3112; P13765; Q29746; Q29825; Q6FHC2" "MHC class II antigen presentation" "Allograft rejection; Ebola virus infection in host" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735659524784303490" "False" "High" "IsMasterProtein" "Q8IV50" "LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LYSMD2 PE=1 SV=1" "0.002" "False" "3.237" "7" "2" "2" "1" "215" "23.4" "5.35" "4.18" "2" "" "" "" "Pf01476" "256586" "ENSG00000140280" "LYSMD2" "hsa:256586; Q5CZ88; Q8IV50; Q8WTV3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624029487017367107" "False" "High" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "0.002" "False" "3.237" "9" "1" "1" "1" "99" "11.2" "4.88" "3.46" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "Kleefstra syndrome" "5" "0" "0.957" "1.054" "1.121" "0.935" "0.950" "1.057" "1.048" "1.020" "0.986" "174.9" "167.4" "184.4" "196.1" "163.6" "166.3" "184.8" "183.3" "178.4" "172.5" "" "" "" "" "" "" "" "" "" "" "140.5" "120.8" "146.4" "131.4" "113.1" "124.7" "129.4" "133.9" "178.4" "140.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-431742904065760490" "False" "High" "IsMasterProtein" "O75955" "Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3" "0.002" "False" "3.235" "3" "1" "1" "1" "427" "47.3" "7.49" "3.09" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "10211" "ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280" "FLOT1" "B4DVY7; hsa:10211; O75955; Q969J8; Q9UHW1; Q9UNV8" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4254147789153280630" "False" "High" "IsMasterProtein" "Q9BZ68" "Putative FERM domain-containing protein FRMD8P1 OS=Homo sapiens OX=9606 GN=FRMD8P1 PE=5 SV=2" "0.002" "False" "3.235" "2" "1" "1" "1" "369" "41.1" "5.82" "2.14" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton" "" "Pf00373" "" "" "FRMD8P1" "A1A4X4; Q9BZ68" "" "" "0" "0" "1.084" "0.974" "1.113" "0.879" "0.970" "0.999" "1.035" "1.054" "0.998" "50.3" "54.5" "49.0" "56.0" "44.2" "48.8" "50.2" "52.0" "53.0" "50.2" "" "" "" "" "" "" "" "" "" "" "40.4" "39.3" "38.9" "37.5" "30.5" "36.6" "35.1" "38.0" "53.0" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858417200274970824" "False" "High" "IsMasterProtein" "Q9BPZ7" "Target of rapamycin complex 2 subunit MAPKAP1 OS=Homo sapiens OX=9606 GN=MAPKAP1 PE=1 SV=2" "0.002" "False" "3.233" "2" "1" "1" "1" "522" "59.1" "7.55" "2.90" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05422, Pf16978, Pf16979" "79109" "ENSG00000119487" "MAPKAP1" "A8K1Z5; B1AMA4; B7Z309; hsa:79109; Q00426; Q5JSV5; Q5JSV6; Q5JSV9; Q658R0; Q699U1; Q699U2; Q699U3; Q699U4; Q6GVJ0; Q6GVJ1; Q6GVJ2; Q9BPZ7" "Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability" "Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Head and neck squamous cell carcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "13" "0" "1.004" "0.966" "1.102" "1.111" "1.047" "1.098" "0.975" "1.090" "0.972" "196.7" "197.6" "190.0" "216.8" "218.5" "206.1" "216.0" "191.8" "214.4" "191.3" "" "" "" "" "" "" "" "" "" "" "158.0" "142.6" "150.9" "145.2" "151.1" "154.6" "151.2" "140.1" "214.4" "155.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839911235887599256" "False" "High" "IsMasterProtein" "Q8N720" "Zinc finger protein 655 OS=Homo sapiens OX=9606 GN=ZNF655 PE=1 SV=3" "0.002" "False" "3.207" "2" "1" "1" "1" "491" "57.4" "7.14" "2.47" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "79027" "ENSG00000197343" "ZNF655" "A4D291; A6NGD3; B4E3M4; B7Z9Q9; D6W5T4; hsa:79027; Q8IV00; Q8N720; Q8TA89; Q96EZ3; Q9BQ85" "Generic Transcription Pathway" "Retinoblastoma gene in cancer" "2" "0" "1.126" "1.169" "0.969" "0.893" "0.959" "0.949" "1.066" "0.961" "1.038" "51.7" "58.2" "60.5" "50.1" "46.2" "49.6" "49.1" "55.1" "49.7" "53.7" "" "" "" "" "" "" "" "" "" "" "41.5" "42.0" "48.0" "33.6" "31.9" "37.2" "34.4" "40.3" "49.7" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4165561941768478758" "False" "High" "IsMasterProtein" "Q9UID6" "Zinc finger protein 639 OS=Homo sapiens OX=9606 GN=ZNF639 PE=1 SV=1" "0.002" "False" "3.204" "3" "1" "1" "1" "485" "56.0" "5.57" "2.16" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "51193" "ENSG00000121864" "ZNF639" "A9X3Z9; D3DNR3; hsa:51193; Q9UID6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3422303379443285128" "False" "High" "IsMasterProtein" "Q8NBI2" "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 OS=Homo sapiens OX=9606 GN=CYB561A3 PE=1 SV=1" "0.002" "False" "3.203" "4" "1" "1" "1" "242" "27.2" "9.60" "3.49" "1" "transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03188" "220002" "ENSG00000162144" "CYB561A3" "B3KPU2; B4DLN9; hsa:220002; J3KQH4; Q6PK96; Q8NBI2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "894930863063919588" "False" "High" "IsMasterProtein" "Q86W34" "Archaemetzincin-2 OS=Homo sapiens OX=9606 GN=AMZ2 PE=1 SV=2" "0.002" "False" "3.201" "3" "1" "1" "1" "360" "41.2" "8.15" "2.72" "1" "protein metabolism" "" "other molecular function" "Pf07998" "51321" "ENSG00000196704" "AMZ2" "A6NLD9; B3KR44; hsa:51321; Q5XKF1; Q86W34; Q9NZE2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "552673094407131667" "False" "High" "IsMasterProtein" "O95639" "Cleavage and polyadenylation specificity factor subunit 4 OS=Homo sapiens OX=9606 GN=CPSF4 PE=1 SV=1" "0.002" "False" "3.199" "6" "2" "2" "2" "269" "30.2" "8.31" "5.10" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf00642, Pf15663" "10898" "ENSG00000160917" "CPSF4" "D6W5S8; hsa:10898; O95639; Q6FGE6; Q86TF8; Q9BTW6" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing" "mRNA processing" "8" "0" "1.092" "1.105" "1.205" "1.171" "1.319" "1.193" "1.235" "1.237" "1.123" "257.8" "281.6" "285.0" "310.8" "301.8" "340.0" "307.6" "318.4" "318.8" "289.6" "" "" "" "" "" "" "" "" "" "" "207.1" "203.2" "226.4" "208.3" "208.7" "255.1" "215.4" "232.5" "318.8" "235.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "300613952239317335" "False" "High" "IsMasterProtein" "O43766" "Lipoyl synthase, mitochondrial OS=Homo sapiens OX=9606 GN=LIAS PE=1 SV=3" "0.002" "False" "3.199" "3" "1" "1" "1" "372" "41.9" "8.59" "2.38" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion" "other molecular function" "Pf04055, Pf16881" "11019" "ENSG00000121897" "LIAS" "A8K873; C9JCF6; hsa:11019; O43766; Q8IV62" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3538958500289371582" "False" "High" "IsMasterProtein" "P49336" "Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1" "0.002" "False" "3.193" "2" "1" "1" "1" "464" "53.3" "8.57" "3.30" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1024" "ENSG00000132964" "CDK8" "hsa:1024; P49336; Q5VUF3; Q6ISB5" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription" "Sterol regulatory element-binding proteins (SREBP) signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; lncRNA in canonical Wnt signaling and colorectal cancer" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7888246173052261501" "False" "High" "IsMasterProtein" "Q9UL16" "Cilia- and flagella-associated protein 45 OS=Homo sapiens OX=9606 GN=CFAP45 PE=1 SV=2" "0.002" "False" "3.193" "3" "2" "2" "2" "551" "65.7" "8.90" "3.10" "2" "transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;nucleus" "other molecular function" "Pf13868" "25790" "ENSG00000213085" "CFAP45" "C9JH28; hsa:25790; Q05BA3; Q5VU18; Q9UL16" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8230923864296422238" "False" "High" "IsMasterProtein" "Q9Y303" "N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2" "0.002" "False" "3.191" "2" "1" "2" "1" "409" "43.7" "6.70" "3.67" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "51005" "ENSG00000162066" "AMDHD2" "B4DL77; hsa:51005; Q8WV54; Q9Y303" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "0.952" "0.934" "0.965" "0.941" "0.930" "0.999" "0.998" "1.034" "1.059" "116.9" "111.3" "109.1" "112.7" "110.0" "108.7" "116.7" "116.6" "120.9" "123.8" "" "" "" "" "" "" "" "" "" "" "93.9" "80.3" "86.7" "75.5" "76.1" "81.6" "81.7" "85.1" "120.9" "100.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431267486707138909" "False" "High" "IsMasterProtein" "Q8TEA7" "TBC domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=TBCK PE=1 SV=4" "0.002" "False" "3.186" "1" "1" "1" "1" "893" "100.6" "6.58" "3.35" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00566, Pf00581" "93627" "ENSG00000145348" "TBCK" "B9A6J1; hsa:93627; Q4W5B3; Q4W5E1; Q6NUP4; Q8N7M8; Q8TEA7; Q8WW57; Q96GV6; Q9P080" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3116404034014267296" "False" "High" "IsMasterProtein" "Q5U5Q3" "RNA-binding E3 ubiquitin-protein ligase MEX3C OS=Homo sapiens OX=9606 GN=MEX3C PE=1 SV=3" "0.002" "False" "3.178" "1" "1" "1" "1" "659" "69.3" "5.00" "3.77" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf13920" "51320" "ENSG00000176624" "MEX3C" "A1L022; Q5U5Q3; Q9NZE3" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.071" "1.025" "1.111" "0.984" "0.968" "1.038" "1.022" "1.046" "1.067" "201.2" "215.6" "206.3" "223.5" "197.9" "194.7" "208.8" "205.6" "210.6" "214.7" "" "" "" "" "" "" "" "" "" "" "161.6" "155.6" "163.9" "149.8" "136.9" "146.1" "146.2" "150.2" "210.6" "174.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386886793218327094" "False" "High" "IsMasterProtein" "Q15776" "Zinc finger protein with KRAB and SCAN domains 8 OS=Homo sapiens OX=9606 GN=ZKSCAN8 PE=1 SV=2" "0.002" "False" "3.178" "3" "2" "2" "1" "578" "65.8" "7.39" "5.31" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf02023" "7745" "ENSG00000198315" "ZKSCAN8" "A1L3D4; B4DYF1; hsa:7745; Q15776; Q4VAR1; Q4VAR2; Q4VAR3; Q9H4T1" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5444771599092088743" "False" "High" "IsMasterProtein" "Q96EY9" "Probable inactive tRNA-specific adenosine deaminase-like protein 3 OS=Homo sapiens OX=9606 GN=ADAT3 PE=1 SV=1" "0.002" "False" "3.171" "4" "1" "1" "1" "351" "38.0" "7.88" "2.95" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00383" "113179" "" "ADAT3" "hsa:113179; Q96EY9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.220" "1.112" "1.193" "1.160" "1.100" "1.087" "1.459" "1.072" "0.977" "52.5" "64.1" "58.4" "62.7" "60.9" "57.8" "57.1" "76.6" "56.3" "51.3" "" "" "" "" "" "" "" "" "" "" "42.2" "46.2" "46.4" "42.0" "42.1" "43.3" "40.0" "56.0" "56.3" "41.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4314325281228425264" "False" "High" "IsMasterProtein" "O15382" "Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2" "0.002" "False" "3.168" "2" "1" "1" "1" "392" "44.3" "8.65" "3.19" "1" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01063" "587" "ENSG00000105552" "BCAT2" "B2RB87; hsa:587; O00269; O15382; Q96KG1; Q9BTB6; Q9BUU6" "Branched-chain amino acid catabolism" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1646282092331670757" "False" "High" "IsMasterProtein" "Q86YE8" "Zinc finger protein 573 OS=Homo sapiens OX=9606 GN=ZNF573 PE=1 SV=4" "0.002" "False" "3.154" "1" "1" "1" "1" "665" "78.1" "9.16" "2.80" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13912" "126231" "ENSG00000189144" "ZNF573" "B7WPE1; hsa:126231; K7EJ45; Q6P1P1; Q7Z7Q3; Q86YE8; Q8N2Q1; Q96BM3; Q96NH0" "Generic Transcription Pathway" "" "1" "0" "0.935" "1.089" "1.076" "1.052" "1.185" "0.948" "0.756" "1.010" "1.078" "31.8" "29.7" "34.6" "34.2" "33.4" "37.6" "30.1" "24.0" "32.1" "34.2" "" "" "" "" "" "" "" "" "" "" "25.5" "21.4" "27.5" "22.9" "23.1" "28.2" "21.1" "17.6" "32.1" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6833769013355988037" "False" "High" "IsMasterProtein" "Q96Q27" "Ankyrin repeat and SOCS box protein 2 OS=Homo sapiens OX=9606 GN=ASB2 PE=1 SV=2" "0.002" "False" "3.150" "2" "1" "1" "1" "635" "70.2" "7.08" "3.28" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf07525, Pf12796, Pf13637" "51676" "ENSG00000100628; ENSG00000278693" "ASB2" "B2RDP9; B4E166; hsa:51676; Q96Q27; Q9NSU5; Q9Y567" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3290991412812475155" "False" "High" "IsMasterProtein" "Q5T9A4" "ATPase family AAA domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ATAD3B PE=1 SV=1" "0.002" "False" "3.144" "1" "1" "1" "1" "648" "72.5" "9.20" "2.66" "1" "cell organization and biogenesis" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00004, Pf12037" "83858" "ENSG00000160072" "ATAD3B" "A8K3H1; hsa:83858; Q5T9A4; Q6ZRB5; Q9BUK4; Q9ULE7" "Neutrophil degranulation" "1p36 copy number variation syndrome" "2" "0" "1.111" "1.049" "1.214" "1.095" "0.979" "1.229" "1.060" "1.069" "1.087" "80.3" "89.2" "84.2" "97.5" "88.0" "78.6" "98.7" "85.1" "85.8" "87.3" "" "" "" "" "" "" "" "" "" "" "64.5" "64.4" "66.9" "65.3" "60.8" "59.0" "69.1" "62.2" "85.8" "71.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3708600255538619001" "False" "High" "IsMasterProtein" "Q6PI26" "Protein SHQ1 homolog OS=Homo sapiens OX=9606 GN=SHQ1 PE=1 SV=2" "0.002" "False" "3.141" "2" "1" "1" "1" "577" "65.1" "4.79" "3.08" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04925, Pf21413" "55164" "ENSG00000144736" "SHQ1" "B4DL05; hsa:55164; Q6MZJ4; Q6PI26; Q7Z748; Q9H7E5; Q9NVS8" "Telomere Extension By Telomerase" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5769529800137255333" "False" "High" "IsMasterProtein" "O94817" "Ubiquitin-like protein ATG12 OS=Homo sapiens OX=9606 GN=ATG12 PE=1 SV=1" "0.002" "False" "3.139" "11" "2" "2" "2" "140" "15.1" "5.10" "4.77" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04110" "9140" "ENSG00000145782" "ATG12" "hsa:9140; O94817; Q6PJV2" "Macroautophagy; Negative regulators of DDX58/IFIH1 signaling; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "Nanoparticle triggered autophagic cell death; Novel intracellular components of RIG-I-like receptor pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Cytosolic DNA-sensing pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "11" "0" "0.975" "1.007" "1.028" "1.018" "1.059" "0.930" "0.937" "0.922" "1.050" "379.5" "369.9" "382.0" "390.1" "386.5" "402.0" "352.9" "355.8" "350.0" "398.6" "" "" "" "" "" "" "" "" "" "" "304.8" "266.9" "303.5" "261.4" "267.3" "301.6" "247.1" "259.8" "350.0" "324.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1235212219621904744" "False" "High" "IsMasterProtein" "Q8IY92" "Structure-specific endonuclease subunit SLX4 OS=Homo sapiens OX=9606 GN=SLX4 PE=1 SV=3" "0.002" "False" "3.135" "0" "1" "1" "1" "1834" "199.9" "6.06" "3.11" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00651, Pf09494" "84464" "ENSG00000188827" "SLX4" "hsa:84464; Q69YT8; Q8IY92; Q8TF15; Q96JP1" "Resolution of D-loop Structures through Holliday Junction Intermediates; Fanconi Anemia Pathway" "Nucleotide excision repair in xeroderma pigmentosum" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694948017889393545" "False" "High" "IsMasterProtein" "Q8N490" "Probable hydrolase PNKD OS=Homo sapiens OX=9606 GN=PNKD PE=1 SV=2" "0.002" "False" "3.133" "2" "1" "1" "1" "385" "42.8" "9.09" "3.12" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00753, Pf16123" "25953" "ENSG00000127838" "PNKD" "A8K1F2; hsa:25953; Q8N490; Q96A48; Q9BU26; Q9NSX4; Q9ULN6; Q9Y4T1" "" "Mitochondrial complex IV assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2922734994360900835" "False" "High" "IsMasterProtein" "P54198" "Protein HIRA OS=Homo sapiens OX=9606 GN=HIRA PE=1 SV=2" "0.002" "False" "3.130" "1" "1" "1" "1" "1017" "111.8" "8.07" "2.65" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf07569" "7290" "ENSG00000100084" "HIRA" "hsa:7290; P54198; Q05BU9; Q8IXN2" "Formation of Senescence-Associated Heterochromatin Foci (SAHF); Replacement of protamines by nucleosomes in the male pronucleus" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4794650797081618468" "False" "High" "IsMasterProtein" "Q86YS3" "Rab11 family-interacting protein 4 OS=Homo sapiens OX=9606 GN=RAB11FIP4 PE=1 SV=1" "0.002" "False" "3.127" "2" "1" "1" "1" "637" "71.9" "4.87" "2.54" "1" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf09457" "84440" "ENSG00000131242" "RAB11FIP4" "hsa:84440; Q52LI1; Q86YS3; Q8N829; Q8NDT7; Q969D8" "" "NF1 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1668082602578177329" "False" "High" "IsMasterProtein" "O95625" "Zinc finger and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ZBTB11 PE=1 SV=2" "0.002" "False" "3.127" "1" "1" "1" "1" "1053" "119.3" "8.66" "2.75" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf13912, Pf17921" "27107" "ENSG00000066422" "ZBTB11" "hsa:27107; O95625; Q2NKP9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8757079958512544915" "False" "High" "IsMasterProtein" "Q96DE5" "Anaphase-promoting complex subunit 16 OS=Homo sapiens OX=9606 GN=ANAPC16 PE=1 SV=1" "0.002" "False" "3.121" "11" "1" "3" "1" "110" "11.7" "4.97" "3.85" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf17256" "119504" "ENSG00000166295" "ANAPC16" "hsa:119504; Q96DE5" "Separation of Sister Chromatids; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "17" "0" "0.892" "0.825" "0.939" "0.990" "1.045" "0.891" "0.884" "0.923" "0.991" "80.6" "71.9" "66.5" "75.7" "79.8" "84.2" "71.8" "71.3" "74.4" "79.9" "" "" "" "" "" "" "" "" "" "" "64.7" "51.9" "52.8" "50.7" "55.2" "63.2" "50.2" "52.0" "74.4" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214058643654551286" "False" "High" "IsMasterProtein" "Q9Y3Y2" "Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2" "0.002" "False" "3.111" "5" "1" "2" "1" "248" "26.4" "12.23" "4.53" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf13865" "26097" "ENSG00000160679" "CHTOP" "D3DV55; hsa:26097; Q0VAQ8; Q2VPI9; Q5T7Y8; Q5T7Y9; Q5T7Z0; Q6NSM4; Q6PB28; Q8WYT9; Q9BUC5; Q9H034; Q9H2L0; Q9Y3Y2" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "0.903" "0.939" "0.984" "1.021" "1.095" "0.920" "0.963" "0.901" "0.854" "42.5" "38.4" "39.9" "41.8" "43.4" "46.5" "39.1" "40.9" "38.3" "36.3" "" "" "" "" "" "" "" "" "" "" "34.1" "27.7" "31.7" "28.0" "30.0" "34.9" "27.4" "29.9" "38.3" "29.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449078799256658420" "False" "High" "IsMasterProtein" "Q53FA7" "Quinone oxidoreductase PIG3 OS=Homo sapiens OX=9606 GN=TP53I3 PE=1 SV=2" "0.002" "False" "3.108" "4" "2" "2" "2" "332" "35.5" "7.17" "4.96" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf00107, Pf08240" "9540" "ENSG00000115129" "TP53I3" "D6W533; hsa:9540; O14679; O14685; Q38G78; Q53FA7; Q6JLE7; Q9BWB8" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "p53 transcriptional gene network; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141620358562250456" "False" "High" "IsMasterProtein" "Q8NCB2" "CaM kinase-like vesicle-associated protein OS=Homo sapiens OX=9606 GN=CAMKV PE=1 SV=2" "0.002" "False" "3.104" "2" "1" "1" "1" "501" "54.3" "5.55" "3.66" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069" "79012" "ENSG00000164076" "CAMKV" "A6NFD4; hsa:79012; Q6FIB8; Q8NBS8; Q8NC85; Q8NCB2; Q8NDU4; Q8WTT8; Q9BQC9; Q9H0Q5" "" "" "0" "0" "0.870" "0.895" "1.095" "0.998" "1.054" "0.964" "0.844" "0.876" "0.782" "53.0" "46.1" "47.4" "58.0" "52.9" "55.8" "51.1" "44.7" "46.4" "41.4" "" "" "" "" "" "" "" "" "" "" "42.5" "33.3" "37.7" "38.9" "36.6" "41.9" "35.8" "32.6" "46.4" "33.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3991295495987680044" "False" "High" "IsMasterProtein" "Q15544" "Transcription initiation factor TFIID subunit 11 OS=Homo sapiens OX=9606 GN=TAF11 PE=1 SV=1" "0.002" "False" "3.099" "4" "1" "1" "1" "211" "23.3" "4.88" "3.91" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf04719" "6882" "ENSG00000064995" "TAF11" "B2R8R3; B4DY18; hsa:6882; Q15544; Q9UHS0" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "10" "0" "1.149" "1.054" "1.151" "1.047" "1.007" "1.133" "1.111" "1.127" "1.065" "352.8" "405.4" "372.0" "406.0" "369.5" "355.5" "399.8" "392.0" "397.8" "375.9" "" "" "" "" "" "" "" "" "" "" "283.4" "292.5" "295.5" "272.0" "255.6" "266.7" "279.9" "286.3" "397.8" "305.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4261899160220204292" "False" "High" "IsMasterProtein" "Q9ULE0" "Protein WWC3 OS=Homo sapiens OX=9606 GN=WWC3 PE=1 SV=4" "0.002" "False" "3.096" "1" "2" "2" "1" "1216" "136.6" "6.42" "3.29" "2" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf00397" "55841" "ENSG00000047644" "WWC3" "A8KA96; hsa:55841; Q659C1; Q9BTQ1; Q9ULE0; T2C6S4" "" "" "0" "0" "1.163" "1.445" "0.971" "1.060" "1.054" "1.442" "1.188" "1.243" "1.168" "29.0" "33.7" "41.9" "28.1" "30.7" "30.5" "41.8" "34.4" "36.0" "33.8" "" "" "" "" "" "" "" "" "" "" "23.3" "24.3" "33.2" "18.8" "21.2" "22.9" "29.3" "25.1" "36.0" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2175266098222278250" "False" "High" "IsMasterProtein" "Q8WVP5" "Tumor necrosis factor alpha-induced protein 8-like protein 1 OS=Homo sapiens OX=9606 GN=TNFAIP8L1 PE=1 SV=2" "0.002" "False" "3.092" "12" "2" "2" "2" "186" "20.8" "9.50" "4.33" "2" "other biological processes" "other cell component" "other molecular function" "Pf05527" "126282" "ENSG00000185361" "TNFAIP8L1" "D6W627; hsa:126282; Q8WVP5" "PI Metabolism" "" "1" "0" "1.222" "0.902" "1.321" "1.217" "1.009" "1.328" "1.050" "0.808" "0.937" "85.0" "103.8" "76.6" "112.2" "103.4" "85.7" "112.8" "89.2" "68.7" "79.6" "" "" "" "" "" "" "" "" "" "" "68.3" "74.9" "60.9" "75.2" "71.5" "64.3" "79.0" "65.1" "68.7" "64.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3752183774953564252" "False" "High" "IsMasterProtein" "Q8WY36" "HMG box transcription factor BBX OS=Homo sapiens OX=9606 GN=BBX PE=1 SV=1" "0.002" "False" "3.079" "2" "2" "2" "2" "941" "105.1" "8.79" "5.43" "2" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09667" "56987" "ENSG00000114439" "BBX" "A2RRM7; hsa:56987; Q2TAJ1; Q7L3J8; Q7LBY8; Q8NDB0; Q8WY35; Q8WY36; Q9H0J6" "" "" "0" "0" "1.024" "1.074" "1.034" "0.801" "0.983" "1.035" "0.867" "0.970" "0.924" "38.0" "38.9" "40.8" "39.3" "30.4" "37.3" "39.3" "32.9" "36.8" "35.1" "" "" "" "" "" "" "" "" "" "" "30.5" "28.1" "32.4" "26.3" "21.0" "28.0" "27.5" "24.0" "36.8" "28.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6585156526220186140" "False" "High" "IsMasterProtein" "Q13610" "Periodic tryptophan protein 1 homolog OS=Homo sapiens OX=9606 GN=PWP1 PE=1 SV=1" "0.002" "False" "3.073" "4" "2" "2" "2" "501" "55.8" "4.77" "1.70" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400" "11137" "ENSG00000136045" "PWP1" "A8K3R6; hsa:11137; Q13610; Q7Z3X9" "" "" "0" "0" "0.700" "1.123" "0.853" "0.938" "0.684" "0.782" "0.726" "0.746" "0.864" "42.2" "29.6" "47.4" "36.0" "39.6" "28.9" "33.0" "30.7" "31.5" "36.5" "" "" "" "" "" "" "" "" "" "" "33.9" "21.3" "37.7" "24.1" "27.4" "21.7" "23.1" "22.4" "31.5" "29.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7079848071820702284" "False" "High" "IsMasterProtein" "Q9BPY3" "Protein FAM118B OS=Homo sapiens OX=9606 GN=FAM118B PE=1 SV=1" "0.002" "False" "3.069" "3" "1" "1" "1" "351" "39.5" "5.99" "3.37" "1" "" "nucleus" "other molecular function" "Pf13289" "79607" "ENSG00000197798" "FAM118B" "hsa:79607; Q9BPY3; Q9H7B0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5273263949641690110" "False" "High" "IsMasterProtein" "Q92630" "Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Homo sapiens OX=9606 GN=DYRK2 PE=1 SV=3" "0.002" "False" "3.065" "1" "1" "1" "1" "601" "66.6" "9.67" "2.94" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8445" "ENSG00000127334" "DYRK2" "B2R9V9; hsa:8445; Q92630; Q9BRB5" "Regulation of TP53 Activity through Phosphorylation" "T cell receptor and co-stimulatory signaling" "2" "0" "0.883" "0.990" "0.987" "0.933" "1.033" "1.016" "1.009" "1.133" "1.079" "130.6" "115.3" "129.3" "128.9" "121.8" "134.9" "132.6" "131.8" "148.0" "141.0" "" "" "" "" "" "" "" "" "" "" "104.9" "83.2" "102.7" "86.3" "84.2" "101.2" "92.9" "96.3" "148.0" "114.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4817136226994286796" "False" "High" "IsMasterProtein" "Q149N8" "E3 ubiquitin-protein ligase SHPRH OS=Homo sapiens OX=9606 GN=SHPRH PE=1 SV=2" "0.003" "False" "3.062" "1" "2" "2" "2" "1683" "193.0" "7.47" "1.93" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00538, Pf13445, Pf21324, Pf21325" "257218" "ENSG00000146414" "SHPRH" "hsa:257218; Q149N8; Q149N9; Q5VV79; Q68DS5; Q7Z5J5; Q8IVE8; Q8IWQ9; Q8N1S8; Q8NBR7" "E3 ubiquitin ligases ubiquitinate target proteins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4219913778501772025" "False" "High" "IsMasterProtein" "Q96PE7" "Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1" "0.003" "False" "3.049" "11" "2" "2" "2" "176" "18.7" "9.09" "3.62" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf13669" "84693" "ENSG00000124370" "MCEE" "hsa:84693; Q53TP1; Q8WW63; Q96PE7" "Propionyl-CoA catabolism" "Vitamin B12 metabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2805060989101184805" "False" "High" "IsMasterProtein" "P11055" "Myosin-3 OS=Homo sapiens OX=9606 GN=MYH3 PE=1 SV=3" "0.003" "False" "3.047" "1" "2" "2" "1" "1940" "223.8" "5.81" "2.34" "2" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4621" "ENSG00000109063" "MYH3" "hsa:4621; P11055; Q15492" "Striated Muscle Contraction" "Striated muscle contraction pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-268519531610469058" "False" "High" "IsMasterProtein" "Q8WUJ0" "Serine/threonine/tyrosine-interacting protein OS=Homo sapiens OX=9606 GN=STYX PE=1 SV=1" "0.003" "False" "3.046" "5" "1" "1" "1" "223" "25.5" "6.29" "3.02" "1" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00782" "6815" "ENSG00000198252" "STYX" "B9EJG0; hsa:6815; Q8WUJ0; Q99850" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662349959999439869" "False" "High" "IsMasterProtein" "Q92871" "Phosphomannomutase 1 OS=Homo sapiens OX=9606 GN=PMM1 PE=1 SV=2" "0.003" "False" "3.044" "5" "2" "2" "1" "262" "29.7" "5.74" "5.23" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03332" "5372" "ENSG00000100417" "PMM1" "A8K003; hsa:5372; Q92586; Q92871" "Synthesis of GDP-mannose" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4252993756600490288" "False" "High" "IsMasterProtein" "Q9BQ24" "Zinc finger FYVE domain-containing protein 21 OS=Homo sapiens OX=9606 GN=ZFYVE21 PE=1 SV=1" "0.003" "False" "3.041" "12" "2" "2" "2" "234" "26.5" "8.41" "2.77" "2" "" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf16696" "79038" "ENSG00000100711" "ZFYVE21" "A8K3A4; hsa:79038; Q86T05; Q96LT1; Q9BQ24" "" "" "0" "0" "1.103" "1.111" "0.949" "1.033" "1.055" "0.942" "0.965" "1.105" "1.085" "201.1" "221.8" "223.5" "190.9" "207.7" "212.2" "189.5" "194.1" "222.2" "218.2" "" "" "" "" "" "" "" "" "" "" "161.5" "160.1" "177.5" "127.9" "143.6" "159.2" "132.7" "141.7" "222.2" "177.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2280173954628743823" "False" "High" "IsMasterProtein" "Q9Y575" "Ankyrin repeat and SOCS box protein 3 OS=Homo sapiens OX=9606 GN=ASB3 PE=1 SV=1" "0.003" "False" "3.037" "2" "1" "1" "1" "518" "57.7" "6.27" "3.52" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf07525, Pf12796" "100302652; 51130" "ENSG00000115239" "ASB3" "B3KPA3; D6W5B4; D6W5B5; G8JLA9; hsa:100302652; hsa:51130; Q2TAI4; Q53TN0; Q53TN8; Q9NVZ2; Q9Y575" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "0.844" "0.775" "0.941" "0.839" "0.805" "0.846" "0.742" "0.759" "0.839" "205.8" "173.6" "159.5" "193.6" "172.7" "165.7" "174.1" "152.6" "156.2" "172.6" "" "" "" "" "" "" "" "" "" "" "165.3" "125.3" "126.7" "129.7" "119.5" "124.3" "121.9" "111.5" "156.2" "140.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3674016433927487468" "False" "High" "IsMasterProtein" "Cont_P02663" "Alpha-S2-casein OS=Bos taurus OX=9913 GN=CSN1S2 PE=1 SV=2" "0.003" "True" "3.034" "9" "2" "2" "2" "222" "26.0" "8.43" "2.14" "2" "stress response;other biological processes" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf00363" "109560546; 282209" "ENSBIXG00000025508; ENSBIXG00005028072; ENSBTAG00000005005" "CSN1S2; LOC109560546; LOC113894643" "A0A4W2DUG8; A0A6P5BZ34; biu:109560546; bta:282209; P02663; Q1RMQ6; Q9TR51" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5056136180857983936" "False" "High" "IsMasterProtein" "P28324" "ETS domain-containing protein Elk-4 OS=Homo sapiens OX=9606 GN=ELK4 PE=1 SV=3" "0.003" "False" "3.034" "2" "1" "1" "1" "431" "46.9" "7.91" "2.68" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "2005" "ENSG00000158711" "ELK4" "hsa:2005; P28323; P28324; Q6GSJ2" "" "Mesodermal commitment pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; ID signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2230295239776997928" "False" "High" "IsMasterProtein" "Q969W3" "Protein VCF1 OS=Homo sapiens OX=9606 GN=VCF1 PE=1 SV=2" "0.003" "False" "3.032" "5" "1" "1" "1" "186" "19.5" "11.27" "3.01" "1" "" "" "" "Pf15434" "84923" "ENSG00000133193" "VCF1" "B4E339; hsa:84923; Q969W3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4045429465415994492" "False" "High" "IsMasterProtein" "Q3ZCQ8" "Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2" "0.003" "False" "3.030" "2" "1" "1" "1" "353" "39.6" "8.37" "2.65" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;mitochondrion;nucleus" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03031" "92609" "ENSG00000105197" "TIMM50" "hsa:92609; Q330K1; Q3ZCQ8; Q6QA00; Q96FJ5; Q96GY2; Q9H370" "Mitochondrial protein import" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7799027560696546609" "False" "High" "IsMasterProtein" "Q49MG5" "Microtubule-associated protein 9 OS=Homo sapiens OX=9606 GN=MAP9 PE=1 SV=3" "0.003" "False" "3.022" "1" "1" "1" "1" "647" "74.2" "7.80" "2.86" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "" "79884" "ENSG00000164114" "MAP9" "hsa:79884; Q49MG5; Q4W5I7; Q68DU1; Q9H781; Q9H7B6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563724113440254403" "False" "High" "IsMasterProtein" "Q7Z6J4" "FYVE, RhoGEF and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FGD2 PE=1 SV=1" "0.003" "False" "3.018" "1" "1" "1" "1" "655" "74.8" "6.93" "2.29" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "221472" "ENSG00000146192" "FGD2" "hsa:221472; Q5T8I1; Q6P6A8; Q6ZNL5; Q7Z6J4; Q8IZ32; Q8N868; Q9H7M2" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "" "3" "0" "1.120" "1.146" "1.233" "0.961" "1.165" "0.949" "0.864" "1.129" "1.155" "27.1" "30.4" "31.1" "33.4" "26.1" "31.6" "25.7" "23.4" "30.6" "31.3" "" "" "" "" "" "" "" "" "" "" "21.8" "21.9" "24.7" "22.4" "18.0" "23.7" "18.0" "17.1" "30.6" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9003669345530149661" "False" "High" "IsMasterProtein" "Q15738" "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=NSDHL PE=1 SV=2" "0.003" "False" "3.016" "3" "1" "1" "1" "373" "41.9" "8.06" "2.47" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01073" "50814" "ENSG00000147383; ENSG00000292192" "NSDHL" "D3DWT6; hsa:50814; O00344; Q15738" "Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "7" "0" "1.314" "1.275" "1.087" "1.481" "1.270" "0.894" "1.221" "1.261" "1.192" "21.7" "28.5" "27.7" "23.6" "32.1" "27.6" "19.4" "26.5" "27.4" "25.9" "" "" "" "" "" "" "" "" "" "" "17.4" "20.6" "22.0" "15.8" "22.2" "20.7" "13.6" "19.3" "27.4" "21.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6814802731580382634" "False" "High" "IsMasterProtein" "Q6SJ96" "TATA box-binding protein-like 2 OS=Homo sapiens OX=9606 GN=TBPL2 PE=2 SV=2" "0.003" "False" "3.015" "4" "2" "2" "2" "343" "38.0" "5.74" "5.42" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "387332" "ENSG00000182521" "TBPL2" "hsa:387332; Q17RU8; Q6SJ96" "Germ layer formation at gastrulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5013600273074776242" "False" "High" "IsMasterProtein" "Q9NZ09" "Ubiquitin-associated protein 1 OS=Homo sapiens OX=9606 GN=UBAP1 PE=1 SV=1" "0.003" "False" "3.014" "2" "1" "1" "1" "502" "55.0" "5.11" "3.67" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf21267" "51271" "ENSG00000165006" "UBAP1" "B7Z348; B7Z8N9; D3DRL7; F5GXE2; F5H0J8; hsa:51271; Q4V759; Q53FP7; Q5T7B3; Q6FI75; Q8NC52; Q8NCG6; Q8NCH9; Q9NZ09" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "" "5" "0" "0.906" "0.979" "1.092" "0.868" "0.908" "1.052" "0.799" "0.961" "0.968" "179.3" "162.4" "175.6" "195.7" "155.5" "162.7" "188.6" "143.3" "172.2" "173.4" "" "" "" "" "" "" "" "" "" "" "144.0" "117.2" "139.5" "131.1" "107.6" "122.1" "132.0" "104.7" "172.2" "141.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4588958554162941925" "False" "High" "IsMasterProtein" "Q53GT1" "Kelch-like protein 22 OS=Homo sapiens OX=9606 GN=KLHL22 PE=1 SV=2" "0.003" "False" "3.014" "1" "1" "1" "1" "634" "71.6" "5.49" "3.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707, Pf13415, Pf13964" "84861" "ENSG00000099910" "KLHL22" "A8K3Q4; A8MTV3; B7Z2G1; D3DX30; hsa:84861; Q53GT1; Q96B68; Q96KC6" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "22q11.2 copy number variation syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8825052418605142423" "False" "High" "IsMasterProtein" "Q8TF30" "WASP homolog-associated protein with actin, membranes and microtubules OS=Homo sapiens OX=9606 GN=WHAMM PE=1 SV=2" "0.003" "False" "2.999" "1" "1" "1" "1" "809" "90.9" "7.08" "3.40" "1" "cell adhesion;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf15871, Pf15920" "123720" "ENSG00000156232" "WHAMM" "hsa:123720; Q8N1J9; Q8TF30" "RHOD GTPase cycle" "15q25 copy number variation" "2" "0" "0.941" "0.965" "0.954" "0.904" "1.087" "1.162" "0.938" "1.110" "0.942" "62.7" "59.0" "60.5" "59.8" "56.7" "68.2" "72.9" "58.8" "69.6" "59.1" "" "" "" "" "" "" "" "" "" "" "50.4" "42.6" "48.1" "40.1" "39.2" "51.2" "51.0" "43.0" "69.6" "48.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618235937448484575" "False" "High" "IsMasterProtein" "P04839" "Cytochrome b-245 heavy chain OS=Homo sapiens OX=9606 GN=CYBB PE=1 SV=2" "0.003" "False" "2.986" "2" "1" "1" "1" "570" "65.3" "8.63" "2.98" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01794, Pf08022, Pf08030" "1536" "ENSG00000165168" "CYBB" "A8K138; hsa:1536; P04839; Q2PP16" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Neutrophil degranulation; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "Alzheimer's disease and miRNA effects; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; Oxidative stress response; Ferroptosis; Alzheimer's disease; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Type II interferon signaling" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "900299520703075400" "False" "High" "IsMasterProtein" "Q8N4W9" "Zinc finger protein 808 OS=Homo sapiens OX=9606 GN=ZNF808 PE=1 SV=2" "0.003" "False" "2.983" "2" "2" "2" "1" "903" "104.8" "9.48" "2.69" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "388558" "ENSG00000198482" "ZNF808" "hsa:388558; Q68CN7; Q8N4W9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3777783708088155115" "False" "High" "IsMasterProtein" "Q96AP0" "Adrenocortical dysplasia protein homolog OS=Homo sapiens OX=9606 GN=ACD PE=1 SV=4" "0.003" "False" "2.974" "2" "1" "1" "1" "458" "48.9" "5.30" "3.96" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10341" "65057" "ENSG00000102977" "ACD" "A0A0C4DGT6; hsa:65057; Q562H5; Q96AP0; Q9H8F9" "Telomere Extension By Telomerase; Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "" "14" "0" "1.029" "1.061" "1.129" "1.069" "0.938" "1.066" "1.098" "1.070" "0.992" "247.5" "254.8" "262.7" "279.5" "264.5" "232.1" "263.8" "271.8" "264.7" "245.5" "" "" "" "" "" "" "" "" "" "" "198.8" "183.8" "208.7" "187.3" "183.0" "174.1" "184.7" "198.5" "264.7" "199.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3115321329155830276" "False" "High" "IsMasterProtein" "Q9P2D0" "Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3" "0.003" "False" "2.974" "1" "1" "1" "1" "1353" "150.4" "7.71" "2.34" "1" "transport;other biological processes" "other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf00651, Pf12796" "25998" "ENSG00000005700; ENSG00000283068" "IBTK" "hsa:25998; Q2QKU2; Q2QKU3; Q2QKU4; Q5TFD7; Q5TFD9; Q8IUQ9; Q8IUY7; Q8TAI4; Q9HBI8; Q9P2D0; Q9Y3T8" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "0.731" "0.891" "0.822" "1.058" "1.058" "1.356" "1.262" "1.123" "1.070" "20.0" "14.6" "17.8" "16.5" "21.2" "21.2" "27.1" "25.3" "22.5" "21.4" "" "" "" "" "" "" "" "" "" "" "16.1" "10.6" "14.2" "11.0" "14.6" "15.9" "19.0" "18.4" "22.5" "17.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660513057168003161" "False" "High" "IsMasterProtein" "Q99805" "Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1" "0.003" "False" "2.960" "2" "1" "1" "1" "663" "75.7" "7.44" "4.24" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9375" "ENSG00000125304" "TM9SF2" "A8K399; hsa:9375; Q2TAY5; Q99805" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112026886534242272" "False" "High" "IsMasterProtein" "Q99653" "Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3" "0.003" "False" "2.956" "6" "1" "1" "1" "195" "22.4" "5.10" "2.76" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00036" "11261" "ENSG00000187446" "CHP1" "B2R6H9; hsa:11261; Q6FHZ9; Q99653" "Hyaluronan uptake and degradation" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "2" "0" "1.155" "0.991" "1.096" "1.073" "1.091" "0.920" "1.032" "1.075" "1.131" "125.9" "145.5" "124.8" "138.1" "135.1" "137.5" "115.9" "129.9" "135.4" "142.4" "" "" "" "" "" "" "" "" "" "" "101.2" "105.0" "99.2" "92.5" "93.5" "103.1" "81.2" "94.9" "135.4" "115.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2592776449693665757" "False" "High" "IsMasterProtein" "O95455" "dTDP-D-glucose 4,6-dehydratase OS=Homo sapiens OX=9606 GN=TGDS PE=1 SV=1" "0.003" "False" "2.945" "2" "1" "1" "1" "350" "40.2" "6.60" "3.87" "1" "other metabolic processes" "" "other molecular function" "Pf16363" "23483" "ENSG00000088451" "TGDS" "hsa:23483; O95455; Q05DQ3; Q2TU31; Q5T3Z2; Q9H1T9" "" "" "0" "0" "0.993" "1.099" "1.062" "1.013" "1.031" "0.935" "0.858" "0.951" "1.047" "99.2" "98.5" "109.0" "105.4" "100.5" "102.3" "92.7" "85.2" "94.3" "103.9" "" "" "" "" "" "" "" "" "" "" "79.7" "71.1" "86.6" "70.6" "69.5" "76.7" "64.9" "62.2" "94.3" "84.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5829793194791297896" "False" "High" "IsMasterProtein" "Q9UKG9" "Peroxisomal carnitine O-octanoyltransferase OS=Homo sapiens OX=9606 GN=CROT PE=1 SV=2" "0.003" "False" "2.945" "1" "1" "1" "1" "612" "70.1" "7.08" "3.20" "1" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00755" "54677" "ENSG00000005469" "CROT" "A4D1D6; E7EQF2; hsa:54677; Q86V17; Q8IUW9; Q9UKG9; Q9Y6I2" "Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA" "" "2" "0" "1.088" "1.041" "1.086" "0.959" "0.953" "1.142" "1.029" "1.133" "1.336" "87.6" "95.3" "91.2" "95.1" "84.0" "83.5" "100.0" "90.1" "99.2" "117.0" "" "" "" "" "" "" "" "" "" "" "70.3" "68.8" "72.4" "63.7" "58.1" "62.7" "70.0" "65.8" "99.2" "95.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7192865757646021535" "False" "High" "IsMasterProtein" "Q7Z7G8" "Intermembrane lipid transfer protein VPS13B OS=Homo sapiens OX=9606 GN=VPS13B PE=1 SV=2" "0.003" "False" "2.943" "1" "2" "2" "2" "4022" "448.4" "6.46" "2.58" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf06650, Pf12624, Pf16909" "157680" "ENSG00000132549" "VPS13B" "C9JD30; hsa:157680; Q709C6; Q709C7; Q7Z7G4; Q7Z7G5; Q7Z7G6; Q7Z7G7; Q7Z7G8; Q8NB77; Q9NWV1; Q9Y4E7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1713406968265840354" "False" "High" "IsMasterProtein" "O60825" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Homo sapiens OX=9606 GN=PFKFB2 PE=1 SV=2" "0.003" "False" "2.938" "2" "1" "1" "1" "505" "58.4" "8.38" "2.27" "1" "other metabolic processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5208" "ENSG00000123836" "PFKFB2" "hsa:5208; O60824; O60825; Q5VVQ3; Q5VVQ4; Q9H3P1" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828511565450602241" "False" "High" "IsMasterProtein" "P46939" "Utrophin OS=Homo sapiens OX=9606 GN=UTRN PE=1 SV=2" "0.003" "False" "2.934" "0" "1" "2" "1" "3433" "394.2" "5.33" "4.63" "1" "cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00569, Pf09068, Pf09069" "7402" "ENSG00000152818" "UTRN" "hsa:7402; P46939; Q5SYY1; Q5SZ57; Q9UJ40" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "Primary focal segmental glomerulosclerosis (FSGS)" "2" "0" "0.896" "0.940" "1.044" "0.922" "1.049" "1.110" "0.966" "0.924" "0.895" "240.0" "215.1" "225.7" "250.5" "221.2" "251.9" "266.4" "231.8" "221.7" "214.9" "" "" "" "" "" "" "" "" "" "" "192.8" "155.2" "179.2" "167.8" "153.0" "189.0" "186.5" "169.3" "221.7" "174.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215482402611759386" "False" "High" "IsMasterProtein" "Q8N9M1" "Uncharacterized protein C19orf47 OS=Homo sapiens OX=9606 GN=C19orf47 PE=1 SV=1" "0.003" "False" "2.931" "3" "1" "1" "1" "422" "44.7" "10.11" "2.53" "1" "" "nucleus" "" "Pf17740, Pf18017" "126526" "ENSG00000160392" "C19orf47" "Q8IZ33; Q8N0V9; Q8N9M1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2814878339460431936" "False" "High" "IsMasterProtein" "O43819" "Protein SCO2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO2 PE=1 SV=3" "0.003" "False" "2.931" "4" "1" "1" "1" "266" "29.8" "8.85" "2.48" "1" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "9997" "ENSG00000284194" "SCO2" "hsa:9997; O43819; Q3T1B5; Q9UK87" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "p53 transcriptional gene network" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8432390134706983747" "False" "High" "IsMasterProtein" "Q9ULT0" "Tetratricopeptide repeat protein 7A OS=Homo sapiens OX=9606 GN=TTC7A PE=1 SV=3" "0.003" "False" "2.923" "2" "2" "2" "2" "858" "96.1" "6.46" "2.51" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf13181, Pf19440" "57217" "ENSG00000068724" "TTC7A" "hsa:57217; Q2T9J9; Q6PIX4; Q8ND67; Q9BUS3; Q9ULT0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176718520801112015" "False" "High" "IsMasterProtein" "P11441" "Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1" "0.003" "False" "2.921" "5" "1" "1" "1" "157" "17.8" "8.66" "2.70" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf17840" "8266" "ENSG00000102178" "UBL4A" "hsa:8266; P11441; Q5HY80" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "0.884" "0.999" "1.059" "0.886" "1.108" "0.887" "1.123" "1.045" "1.084" "80.7" "71.3" "80.6" "85.4" "71.5" "89.3" "71.6" "90.6" "84.3" "87.4" "" "" "" "" "" "" "" "" "" "" "64.8" "51.4" "64.0" "57.2" "49.4" "67.0" "50.1" "66.1" "84.3" "71.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7308711199030270349" "False" "High" "IsMasterProtein" "A6ND36" "Protein FAM83G OS=Homo sapiens OX=9606 GN=FAM83G PE=1 SV=2" "0.003" "False" "2.918" "1" "1" "1" "1" "823" "90.8" "6.39" "2.43" "1" "signal transduction" "cytosol;nucleus" "other molecular function" "Pf07894" "644815" "ENSG00000188522" "FAM83G" "A6ND36; hsa:644815; Q3KQZ4; Q6ZW60" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8165689774405731487" "False" "High" "IsMasterProtein" "Q9NS18" "Glutaredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX2 PE=1 SV=1" "0.003" "False" "2.915" "6" "1" "1" "1" "164" "18.0" "9.11" "2.90" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462" "51022" "ENSG00000023572" "GLRX2" "hsa:51022; Q3LR69; Q7L1N7; Q96JC0; Q9NS18; Q9Y3D4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5281205603675225167" "False" "High" "IsMasterProtein" "Q9NX76" "CKLF-like MARVEL transmembrane domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CMTM6 PE=1 SV=1" "0.003" "False" "2.912" "5" "1" "1" "1" "183" "20.4" "5.29" "2.62" "1" "transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "" "Pf01284" "54918" "ENSG00000091317" "CMTM6" "hsa:54918; Q6IAC4; Q9NX76" "Neutrophil degranulation" "" "1" "0" "0.959" "0.891" "1.232" "1.210" "0.998" "1.344" "1.059" "1.027" "1.037" "98.0" "94.0" "87.3" "120.8" "118.6" "97.8" "131.8" "103.8" "100.6" "101.7" "" "" "" "" "" "" "" "" "" "" "78.7" "67.8" "69.4" "80.9" "82.0" "73.4" "92.3" "75.8" "100.6" "82.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6865133109964514058" "False" "High" "IsMasterProtein" "Q9NVS2" "Large ribosomal subunit protein mL66 OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1" "0.003" "False" "2.899" "8" "2" "2" "2" "196" "22.2" "10.33" "5.44" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01084" "55168" "ENSG00000096080" "MRPS18A" "A6XND3; hsa:55168; Q5QPA4; Q9NVS2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.949" "0.932" "1.022" "0.863" "0.920" "0.894" "0.932" "0.933" "0.905" "102.8" "97.6" "95.8" "105.1" "88.8" "94.6" "91.9" "95.9" "96.0" "93.0" "" "" "" "" "" "" "" "" "" "" "82.6" "70.4" "76.1" "70.4" "61.4" "71.0" "64.3" "70.0" "96.0" "75.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8018768357268208371" "False" "High" "IsMasterProtein" "Q9P1U0" "DNA-directed RNA polymerase I subunit RPA12 OS=Homo sapiens OX=9606 GN=POLR1H PE=1 SV=1" "0.003" "False" "2.897" "6" "1" "1" "1" "126" "13.9" "5.06" "3.40" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096" "30834" "ENSG00000066379; ENSG00000206502; ENSG00000224859; ENSG00000233795; ENSG00000235176; ENSG00000235443; ENSG00000236808; ENSG00000236949" "POLR1H" "hsa:30834; Q9P1U0" "RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "7" "0" "1.035" "1.080" "1.113" "1.260" "1.223" "1.196" "1.151" "1.168" "1.171" "234.6" "242.7" "253.4" "261.0" "295.7" "287.0" "280.6" "269.9" "274.0" "274.8" "" "" "" "" "" "" "" "" "" "" "188.4" "175.1" "201.3" "174.9" "204.5" "215.3" "196.5" "197.1" "274.0" "223.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737789148651549835" "False" "High" "IsMasterProtein" "Q8TCN5" "Zinc finger protein 507 OS=Homo sapiens OX=9606 GN=ZNF507 PE=1 SV=2" "0.003" "False" "2.892" "2" "2" "2" "2" "953" "105.7" "5.72" "3.26" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "22847" "ENSG00000168813" "ZNF507" "A8K911; hsa:22847; Q2TBF1; Q6MZU0; Q8TCN5; Q9UPR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7809965917378949544" "False" "High" "IsMasterProtein" "P42892" "Endothelin-converting enzyme 1 OS=Homo sapiens OX=9606 GN=ECE1 PE=1 SV=2" "0.003" "False" "2.886" "1" "1" "1" "1" "770" "87.1" "5.88" "2.54" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01431, Pf05649" "1889" "ENSG00000117298" "ECE1" "A8K3P1; B4E291; hsa:1889; P42892; Q14217; Q17RN5; Q2Z2K8; Q58GE7; Q5THM5; Q5THM7; Q5THM8; Q9UJQ6; Q9UPF4; Q9UPM4; Q9Y501" "Peptide ligand-binding receptors" "Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Melatonin metabolism and effects; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5068408692238139338" "False" "High" "IsMasterProtein" "P36955" "Pigment epithelium-derived factor OS=Homo sapiens OX=9606 GN=SERPINF1 PE=1 SV=4" "0.003" "True" "2.885" "3" "1" "1" "1" "418" "46.3" "6.38" "0.00" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "enzyme regulator activity" "Pf00079" "5176" "ENSG00000132386" "SERPINF1" "F1T092; hsa:5176; P36955; Q13236; Q2TU83; Q96CT1; Q96R01; Q9BWA4" "" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Type I collagen synthesis in the context of osteogenesis imperfecta; GPR143 in melanocytes and retinal pigment epithelium cells; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7114362037868025430" "False" "High" "IsMasterProtein" "Q5THK1" "Protein PRR14L OS=Homo sapiens OX=9606 GN=PRR14L PE=1 SV=1" "0.003" "False" "2.881" "0" "1" "1" "1" "2151" "237.2" "6.33" "1.79" "1" "" "" "" "Pf15386" "253143" "ENSG00000183530" "PRR14L" "hsa:253143; Q5THK1; Q5THK4; Q6ZNN1; Q6ZWH0; Q8IW74; Q9H5T4" "" "" "0" "0" "1.029" "0.781" "1.261" "0.995" "0.941" "1.425" "1.013" "1.070" "1.133" "20.2" "20.8" "15.8" "25.5" "20.1" "19.0" "28.8" "20.4" "21.6" "22.9" "" "" "" "" "" "" "" "" "" "" "16.2" "15.0" "12.5" "17.1" "13.9" "14.3" "20.1" "14.9" "21.6" "18.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819084498940790760" "False" "High" "IsMasterProtein" "Q6ZVM7" "TOM1-like protein 2 OS=Homo sapiens OX=9606 GN=TOM1L2 PE=1 SV=1" "0.003" "False" "2.881" "3" "2" "2" "2" "507" "55.5" "4.79" "4.50" "2" "transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00790, Pf03127" "146691" "ENSG00000175662" "TOM1L2" "B7Z2L7; B7Z7F4; hsa:146691; Q6ZVM7; Q86V61; Q8TDE7; Q96M88" "" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3365400803270847395" "False" "High" "IsMasterProtein" "Q8N6F7" "Germinal center-associated signaling and motility protein OS=Homo sapiens OX=9606 GN=GCSAM PE=1 SV=1" "0.003" "False" "2.880" "7" "1" "1" "1" "178" "21.0" "6.52" "2.72" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf15666" "257144" "ENSG00000174500; ENSG00000284925" "GCSAM" "C9JD17; C9JUG6; hsa:257144; Q8N6F7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5978102986579792947" "False" "High" "IsMasterProtein" "Q69YL0" "Protein NCBP2AS2 OS=Homo sapiens OX=9606 GN=NCBP2AS2 PE=1 SV=1" "0.003" "False" "2.879" "8" "1" "1" "1" "99" "10.9" "12.00" "3.20" "1" "" "" "" "" "" "ENSG00000270170" "NCBP2AS2" "Q69YL0" "" "3q29 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8876703773954477578" "False" "High" "IsMasterProtein" "O43759" "Synaptogyrin-1 OS=Homo sapiens OX=9606 GN=SYNGR1 PE=1 SV=2" "0.003" "False" "2.867" "5" "1" "1" "1" "233" "25.4" "4.68" "2.22" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01284" "9145" "ENSG00000100321" "SYNGR1" "A6NP69; A8K0E2; hsa:9145; O43757; O43758; O43759; Q53Y02; Q96J56; Q9UGZ4" "Neutrophil degranulation" "" "1" "0" "1.072" "1.156" "1.313" "1.416" "1.237" "1.095" "1.218" "1.293" "1.220" "106.8" "114.4" "123.4" "140.2" "151.2" "132.0" "116.9" "130.0" "138.1" "130.3" "" "" "" "" "" "" "" "" "" "" "85.8" "82.6" "98.0" "93.9" "104.6" "99.1" "81.8" "94.9" "138.1" "105.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5466104877927359471" "False" "High" "IsMasterProtein" "Q92565" "Rap guanine nucleotide exchange factor 5 OS=Homo sapiens OX=9606 GN=RAPGEF5 PE=1 SV=1" "0.003" "False" "2.863" "1" "1" "1" "1" "580" "67.7" "6.30" "2.74" "1" "developmental processes;signal transduction" "plasma membrane;other membranes;nucleus" "enzyme regulator activity;other molecular function" "Pf00617, Pf00618" "9771" "ENSG00000136237" "RAPGEF5" "A4D140; hsa:9771; Q8IXU5; Q92565" "" "Clear cell renal cell carcinoma pathways; Ras signaling" "2" "0" "1.016" "0.920" "0.930" "0.948" "1.084" "1.063" "0.928" "1.025" "1.000" "53.4" "54.3" "49.2" "49.7" "50.6" "57.9" "56.8" "49.6" "54.8" "53.4" "" "" "" "" "" "" "" "" "" "" "42.9" "39.2" "39.1" "33.3" "35.0" "43.5" "39.8" "36.2" "54.8" "43.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-760926983399472078" "False" "High" "IsMasterProtein" "P57060" "RWD domain-containing protein 2B OS=Homo sapiens OX=9606 GN=RWDD2B PE=1 SV=1" "0.003" "False" "2.862" "5" "2" "2" "2" "319" "36.3" "5.87" "5.59" "2" "" "" "" "Pf05773, Pf06544" "10069" "ENSG00000156253; ENSG00000291523" "RWDD2B" "hsa:10069; P57060" "" "" "0" "0" "1.035" "1.051" "1.046" "1.003" "1.013" "0.940" "0.870" "0.944" "1.014" "509.5" "527.5" "535.6" "532.8" "511.1" "516.0" "478.8" "443.4" "481.1" "516.4" "" "" "" "" "" "" "" "" "" "" "409.2" "380.6" "425.4" "357.0" "353.4" "387.1" "335.2" "323.8" "481.1" "420.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6345755563908403634" "False" "High" "IsMasterProtein" "Q9NQG7" "BLOC-3 complex member HPS4 OS=Homo sapiens OX=9606 GN=HPS4 PE=1 SV=2" "0.003" "False" "2.857" "2" "1" "1" "1" "708" "76.9" "5.45" "2.24" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf19031, Pf19033" "89781" "ENSG00000100099" "HPS4" "B1AHQ4; Q5H8V6; Q96LX6; Q9BY93; Q9NQG7; Q9UH37; Q9UH38" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "673060285531934523" "False" "High" "IsMasterProtein" "Q8IWF6" "Protein DENND6A OS=Homo sapiens OX=9606 GN=DENND6A PE=1 SV=1" "0.003" "False" "2.855" "1" "1" "1" "1" "608" "69.5" "8.27" "2.81" "1" "other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf09794" "201627" "ENSG00000174839" "DENND6A" "hsa:201627; Q7Z5T4; Q8IWF6; Q8N235; Q8TEG8" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1742202389940879179" "False" "High" "IsMasterProtein" "Q5VTE6" "Protein angel homolog 2 OS=Homo sapiens OX=9606 GN=ANGEL2 PE=1 SV=1" "0.003" "False" "2.853" "2" "1" "1" "1" "544" "62.3" "7.81" "2.54" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf19339" "90806" "ENSG00000174606" "ANGEL2" "B7Z2U4; D3DTA3; hsa:90806; Q5VTE6; Q86X13; Q8NHH3" "" "" "0" "0" "0.911" "1.142" "1.209" "1.000" "1.068" "0.924" "1.015" "1.151" "0.953" "37.6" "34.2" "42.9" "45.4" "37.6" "40.1" "34.7" "38.1" "43.3" "35.8" "" "" "" "" "" "" "" "" "" "" "30.2" "24.7" "34.1" "30.4" "26.0" "30.1" "24.3" "27.8" "43.3" "29.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5116205605619635126" "False" "High" "IsMasterProtein" "Q96NY9" "Crossover junction endonuclease MUS81 OS=Homo sapiens OX=9606 GN=MUS81 PE=1 SV=3" "0.003" "False" "2.850" "4" "1" "1" "1" "551" "61.1" "9.73" "2.45" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02732, Pf21136, Pf21292" "80198" "ENSG00000172732" "MUS81" "hsa:80198; Q96NY9; Q9H7D9" "Resolution of D-loop Structures through Holliday Junction Intermediates; Fanconi Anemia Pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476586099519423561" "False" "High" "IsMasterProtein" "Q9UI43" "rRNA methyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=MRM2 PE=1 SV=1" "0.004" "False" "2.842" "3" "1" "1" "1" "246" "27.4" "9.50" "3.24" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf01728" "29960" "ENSG00000122687" "MRM2" "hsa:29960; Q24JR8; Q9UI43" "rRNA modification in the mitochondrion" "" "1" "0" "0.976" "0.808" "1.086" "0.991" "0.831" "1.016" "0.956" "0.982" "0.895" "93.7" "91.5" "75.7" "101.8" "92.9" "77.9" "95.3" "89.6" "92.1" "83.9" "" "" "" "" "" "" "" "" "" "" "75.3" "66.0" "60.2" "68.2" "64.2" "58.4" "66.7" "65.5" "92.1" "68.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654378889917812669" "False" "High" "IsMasterProtein" "Q9BQ90" "Kelch domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KLHDC3 PE=1 SV=1" "0.004" "False" "2.841" "2" "1" "1" "1" "382" "43.1" "8.07" "2.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf07646, Pf13418, Pf13964" "116138" "ENSG00000124702" "KLHDC3" "A8K2W9; hsa:116138; Q9BQ90" "XBP1(S) activates chaperone genes" "" "1" "0" "1.158" "1.206" "1.168" "1.264" "1.206" "1.097" "1.000" "1.330" "1.327" "87.2" "100.9" "105.1" "101.8" "110.2" "105.2" "95.7" "87.1" "116.0" "115.7" "" "" "" "" "" "" "" "" "" "" "70.0" "72.8" "83.5" "68.2" "76.2" "78.9" "67.0" "63.6" "116.0" "94.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6685478821626723375" "False" "High" "IsMasterProtein" "Q9BUB4" "tRNA-specific adenosine deaminase 1 OS=Homo sapiens OX=9606 GN=ADAT1 PE=1 SV=1" "0.004" "False" "2.827" "2" "1" "1" "1" "502" "55.4" "9.01" "3.00" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf02137" "23536" "ENSG00000065457" "ADAT1" "hsa:23536; Q9BUB4; Q9NVB7; Q9UNG3" "tRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8565311044506647969" "False" "High" "IsMasterProtein" "Q7RTN6" "STE20-related kinase adapter protein alpha OS=Homo sapiens OX=9606 GN=STRADA PE=1 SV=1" "0.004" "False" "2.821" "3" "1" "1" "1" "431" "48.3" "6.48" "2.51" "1" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00069" "92335" "ENSG00000266173" "STRADA" "B4DDE3; B4DW17; hsa:92335; J3KTC9; Q5JPI2; Q7RTN6; Q7Z4K9; Q8NC31; Q8NCF1; Q9H272" "Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2071864531841837992" "False" "High" "IsMasterProtein" "Q07912" "Activated CDC42 kinase 1 OS=Homo sapiens OX=9606 GN=TNK2 PE=1 SV=3" "0.004" "False" "2.812" "1" "1" "1" "1" "1038" "114.5" "7.25" "2.40" "1" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf07714, Pf09027, Pf11555, Pf14604" "10188" "ENSG00000061938" "TNK2" "hsa:10188; Q07912; Q6ZMQ0; Q8N6U7; Q96H59" "" "Focal adhesion; Oxidative damage response; EGF/EGFR signaling pathway; G13 signaling pathway" "4" "0" "0.844" "0.910" "1.114" "1.034" "0.857" "0.994" "1.040" "0.997" "0.978" "102.8" "86.8" "93.5" "114.5" "106.2" "88.1" "102.1" "106.9" "102.5" "100.5" "" "" "" "" "" "" "" "" "" "" "82.5" "62.6" "74.2" "76.7" "73.5" "66.1" "71.5" "78.1" "102.5" "81.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8778446884232701791" "False" "High" "IsMasterProtein" "Q9UK97" "F-box only protein 9 OS=Homo sapiens OX=9606 GN=FBXO9 PE=1 SV=1" "0.004" "False" "2.811" "2" "1" "1" "1" "447" "52.3" "6.15" "0.00" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646, Pf19270" "26268" "ENSG00000112146" "FBXO9" "A6NFW3; B3KMM6; hsa:26268; O75986; Q59EH8; Q6PKH7; Q9NT57; Q9UK97; Q9Y593" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288678854882700202" "False" "High" "IsMasterProtein" "Q7Z3C6" "Autophagy-related protein 9A OS=Homo sapiens OX=9606 GN=ATG9A PE=1 SV=3" "0.004" "False" "2.799" "2" "1" "1" "1" "839" "94.4" "6.67" "2.31" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf04109" "79065" "ENSG00000198925" "ATG9A" "hsa:79065; Q3ZAQ6; Q6P0N7; Q7Z317; Q7Z320; Q7Z3C6; Q8NDK6; Q8WU65; Q9BVL5; Q9H6L1; Q9HAG7" "Macroautophagy" "Autophagy; Primary ovarian insufficiency" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5618059133762904745" "False" "High" "IsMasterProtein" "Q1ZZU3" "DNA repair protein SWI5 homolog OS=Homo sapiens OX=9606 GN=SWI5 PE=1 SV=1" "0.004" "False" "2.785" "5" "1" "1" "1" "235" "26.7" "10.24" "2.47" "1" "DNA metabolism;stress response;other biological processes" "nucleus" "" "Pf07061" "375757" "" "SWI5" "hsa:375757; Q1ZZU3; Q5SYX7; Q5SYX8; Q8N2W6" "" "" "0" "0" "0.859" "0.955" "0.873" "1.184" "0.887" "1.062" "1.025" "0.944" "0.945" "53.6" "46.1" "51.2" "46.9" "63.5" "47.6" "57.0" "55.0" "50.7" "50.7" "" "" "" "" "" "" "" "" "" "" "43.1" "33.3" "40.7" "31.4" "43.9" "35.7" "39.9" "40.2" "50.7" "41.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5259083941231079932" "False" "High" "IsMasterProtein" "Q7Z4G1" "COMM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=COMMD6 PE=1 SV=1" "0.004" "False" "2.784" "11" "1" "3" "1" "85" "9.6" "6.00" "5.68" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07258" "170622" "ENSG00000188243" "COMMD6" "A6NF28; B7ZLN0; hsa:170622; Q5TBK4; Q7Z4G1" "Neddylation" "" "1" "0" "1.080" "0.993" "1.244" "1.092" "1.202" "0.779" "0.743" "0.726" "0.991" "101.3" "109.4" "100.6" "126.0" "110.6" "121.8" "78.9" "75.3" "73.5" "100.4" "" "" "" "" "" "" "" "" "" "" "81.4" "78.9" "79.9" "84.4" "76.5" "91.4" "55.2" "55.0" "73.5" "81.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629092038123866655" "False" "High" "IsMasterProtein" "Q86TP1" "Exopolyphosphatase PRUNE1 OS=Homo sapiens OX=9606 GN=PRUNE1 PE=1 SV=2" "0.004" "False" "2.773" "3" "1" "1" "1" "453" "50.2" "5.50" "2.97" "1" "other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01368, Pf02833" "58497" "ENSG00000143363" "PRUNE1" "B2RCH8; B4DFL7; Q5SZF9; Q659E5; Q6P4E0; Q86TP1; Q8N654; Q96JU5; Q9C071; Q9C072; Q9UIV0" "" "" "0" "0" "0.711" "1.047" "0.953" "0.926" "0.860" "0.835" "1.017" "1.040" "0.887" "24.9" "17.7" "26.1" "23.7" "23.1" "21.4" "20.8" "25.3" "25.9" "22.1" "" "" "" "" "" "" "" "" "" "" "20.0" "12.8" "20.7" "15.9" "16.0" "16.1" "14.5" "18.5" "25.9" "18.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4433191864106447347" "False" "High" "IsMasterProtein" "Q96N38" "Zinc finger protein 714 OS=Homo sapiens OX=9606 GN=ZNF714 PE=1 SV=3" "0.004" "False" "2.767" "4" "2" "2" "2" "554" "63.8" "9.10" "6.44" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "148206" "" "ZNF714" "hsa:148206; Q49AI1; Q86W65; Q8ND40; Q96N38" "Generic Transcription Pathway" "" "1" "0" "1.185" "1.099" "0.875" "1.168" "1.162" "0.730" "1.039" "0.971" "1.100" "113.1" "134.1" "124.3" "99.0" "132.2" "131.4" "82.5" "117.5" "109.8" "124.4" "" "" "" "" "" "" "" "" "" "" "90.9" "96.7" "98.7" "66.3" "91.4" "98.6" "57.8" "85.8" "109.8" "101.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934438525806986251" "False" "High" "IsMasterProtein" "Q7Z7K0" "COX assembly mitochondrial protein homolog OS=Homo sapiens OX=9606 GN=CMC1 PE=1 SV=1" "0.004" "False" "2.765" "9" "1" "1" "1" "106" "12.5" "8.63" "2.37" "1" "" "mitochondrion" "other molecular function" "Pf08583" "152100" "ENSG00000187118" "CMC1" "hsa:152100; Q68DJ7; Q7Z7K0" "" "Mitochondrial complex IV assembly" "1" "0" "1.657" "1.017" "1.295" "1.283" "1.440" "1.419" "1.309" "1.445" "1.161" "28.2" "46.7" "28.7" "36.5" "36.2" "40.6" "40.0" "36.9" "40.7" "32.7" "" "" "" "" "" "" "" "" "" "" "22.6" "33.7" "22.8" "24.4" "25.0" "30.4" "28.0" "26.9" "40.7" "26.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4566145074236190376" "False" "High" "IsMasterProtein" "P15289" "Arylsulfatase A OS=Homo sapiens OX=9606 GN=ARSA PE=1 SV=3" "0.004" "False" "2.754" "3" "1" "1" "1" "507" "53.6" "6.07" "2.86" "1" "other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00884, Pf14707" "410" "ENSG00000100299" "ARSA" "B2RCA6; B7XD04; F8WCC8; hsa:410; P15289; Q6ICI5; Q96CJ0" "Neutrophil degranulation; Glycosphingolipid catabolism; The activation of arylsulfatases" "Degradation pathway of sphingolipids, including diseases" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8606827125861078695" "False" "High" "IsMasterProtein" "Q6ZU67" "BEN domain-containing protein 4 OS=Homo sapiens OX=9606 GN=BEND4 PE=1 SV=3" "0.004" "False" "2.750" "2" "1" "1" "1" "534" "58.3" "6.13" "2.64" "1" "" "" "nucleic acid binding activity" "Pf10523" "389206" "ENSG00000188848" "BEND4" "A1A5D6; A1A5D7; C9JQZ5; hsa:389206; Q58A26; Q58A27; Q6ZU67" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1936196132069053391" "False" "High" "IsMasterProtein" "Q8WXA9" "Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1" "0.004" "False" "2.747" "3" "1" "1" "1" "508" "59.3" "10.39" "2.55" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "140890" "ENSG00000153914" "SREK1" "A4FTW3; hsa:140890; Q2M1J0; Q86X37; Q8WXA9" "" "mRNA processing" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6647078469160461011" "False" "High" "IsMasterProtein" "Q00722" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Homo sapiens OX=9606 GN=PLCB2 PE=1 SV=2" "0.004" "False" "2.746" "1" "1" "1" "1" "1185" "133.9" "6.29" "2.07" "1" "other metabolic processes;transport;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5330" "ENSG00000137841" "PLCB2" "A8K6J2; B9EGH5; Q00722" "G alpha (q) signalling events; Sensory perception of sweet, bitter, and umami (glutamate) taste; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; Synthesis of IP3 and IP4 in the cytosol; PLC beta mediated events; Acetylcholine regulates insulin secretion" "MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Chemokine signaling pathway; GPR40 pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease" "23" "0" "0.995" "1.020" "1.077" "1.044" "0.960" "0.924" "0.921" "0.880" "0.961" "327.8" "326.1" "334.5" "353.0" "342.1" "314.8" "302.9" "302.0" "288.6" "315.1" "" "" "" "" "" "" "" "" "" "" "263.3" "235.3" "265.7" "236.5" "236.6" "236.2" "212.1" "220.6" "288.6" "256.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291064356522640583" "False" "High" "IsMasterProtein" "Q86VV8" "Rotatin OS=Homo sapiens OX=9606 GN=RTTN PE=1 SV=3" "0.004" "False" "2.732" "0" "1" "1" "1" "2226" "248.5" "6.70" "3.03" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "" "Pf14726" "25914" "ENSG00000176225" "RTTN" "hsa:25914; Q68CS9; Q6ZRL8; Q6ZTK3; Q86TG4; Q86VV8; Q8N8N8; Q8TBQ4; Q96IN9; Q9UFJ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6924032991954886794" "False" "High" "IsMasterProtein" "Q92624" "Amyloid protein-binding protein 2 OS=Homo sapiens OX=9606 GN=APPBP2 PE=1 SV=2" "0.004" "False" "2.729" "2" "1" "1" "1" "585" "66.8" "6.90" "2.89" "1" "protein metabolism;other metabolic processes;transport" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13374, Pf13424" "10513" "ENSG00000062725" "APPBP2" "A8K862; hsa:10513; O95095; Q8WVC9; Q92624" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5473417125959454291" "False" "High" "IsMasterProtein" "Q12766" "HMG domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGXB3 PE=1 SV=3" "0.004" "False" "2.724" "2" "1" "1" "1" "1292" "141.0" "6.02" "2.32" "1" "" "nucleus" "nucleic acid binding activity" "Pf09011, Pf18717" "22993" "ENSG00000113716" "HMGXB3" "G5E9Y4; hsa:22993; Q12766; Q86UG3; Q9UMF4" "" "" "0" "0" "1.075" "0.577" "1.489" "1.105" "0.920" "0.986" "1.184" "1.047" "1.091" "21.9" "23.6" "12.7" "32.6" "24.2" "20.2" "21.6" "26.0" "23.0" "23.9" "" "" "" "" "" "" "" "" "" "" "17.6" "17.0" "10.1" "21.9" "16.8" "15.1" "15.1" "19.0" "23.0" "19.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1779891872713868152" "False" "High" "IsMasterProtein" "Q9UMX1" "Suppressor of fused homolog OS=Homo sapiens OX=9606 GN=SUFU PE=1 SV=2" "0.004" "False" "2.713" "3" "1" "1" "1" "484" "53.9" "5.33" "0.00" "1" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05076, Pf12470" "51684" "ENSG00000107882" "SUFU" "hsa:51684; Q7LCP7; Q9NT90; Q9NZ07; Q9UHK2; Q9UHM8; Q9UMX1; Q9UMY0" "Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state" "Hedgehog signaling pathway; Joubert syndrome; Hedgehog signaling pathway; Ciliopathies; Bardet-Biedl syndrome" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-234587077679188092" "False" "High" "IsMasterProtein" "Q8IYL2" "Probable tRNA (uracil-O(2)-)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT44 PE=1 SV=2" "0.004" "False" "2.711" "1" "1" "1" "1" "757" "84.6" "7.27" "2.89" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf07757" "152992" "ENSG00000155275" "TRMT44" "hsa:152992; Q8IYL2; Q8NA95" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.106" "1.061" "1.163" "1.087" "1.142" "1.235" "1.178" "1.052" "1.092" "191.7" "212.1" "203.5" "223.0" "208.5" "219.0" "236.7" "225.9" "201.6" "209.3" "" "" "" "" "" "" "" "" "" "" "154.0" "153.0" "161.6" "149.4" "144.2" "164.3" "165.7" "164.9" "201.6" "170.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2556880978610824670" "False" "High" "IsMasterProtein" "P62256" "Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1" "0.004" "False" "2.710" "4" "1" "1" "1" "183" "20.6" "4.67" "2.05" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "7328" "ENSG00000186591" "UBE2H" "A4D1L6; C9JY93; hsa:7328; P37286; P62256; Q7Z6F4" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Ciliary landscape" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5639426559288223252" "False" "High" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "0.004" "False" "2.707" "6" "1" "1" "1" "172" "18.8" "5.69" "2.04" "1" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "1.167" "1.017" "1.068" "1.347" "1.181" "1.232" "1.274" "1.300" "1.156" "97.5" "113.8" "99.2" "104.1" "131.3" "115.1" "120.1" "124.2" "126.8" "112.7" "" "" "" "" "" "" "" "" "" "" "78.3" "82.1" "78.8" "69.8" "90.8" "86.4" "84.1" "90.7" "126.8" "91.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3889870800150504402" "False" "High" "IsMasterProtein" "Q8N5C8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 OS=Homo sapiens OX=9606 GN=TAB3 PE=1 SV=3" "0.004" "False" "2.706" "1" "1" "1" "1" "712" "78.6" "8.54" "2.12" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02845" "257397" "ENSG00000157625" "TAB3" "A6NDD9; Q6VQR0; Q8N5C8" "FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "IL-1 signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling pathway" "18" "0" "1.033" "1.036" "1.025" "0.929" "0.825" "1.031" "0.918" "0.939" "0.896" "59.7" "61.6" "61.8" "61.2" "55.5" "49.2" "61.5" "54.8" "56.0" "53.4" "" "" "" "" "" "" "" "" "" "" "47.9" "44.5" "49.1" "41.0" "38.4" "36.9" "43.1" "40.0" "56.0" "43.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2768731698011358698" "False" "High" "IsMasterProtein" "Q9NQ89" "Ferry endosomal RAB5 effector complex subunit 3 OS=Homo sapiens OX=9606 GN=FERRY3 PE=1 SV=1" "0.004" "False" "2.702" "3" "1" "1" "1" "552" "63.8" "6.37" "1.78" "1" "other biological processes" "other cell component" "" "Pf10154" "57102" "ENSG00000047621" "C12orf4" "D3DUQ8; hsa:57102; Q6MZH5; Q9NQ89" "" "" "0" "0" "1.038" "0.885" "1.271" "1.009" "1.083" "1.226" "0.792" "1.112" "1.174" "18.3" "19.0" "16.2" "23.3" "18.5" "19.8" "22.5" "14.5" "20.4" "21.5" "" "" "" "" "" "" "" "" "" "" "14.7" "13.7" "12.9" "15.6" "12.8" "14.9" "15.7" "10.6" "20.4" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7772717981481829495" "False" "High" "IsMasterProtein" "Q96T68" "Histone-lysine N-methyltransferase SETDB2 OS=Homo sapiens OX=9606 GN=SETDB2 PE=1 SV=2" "0.004" "False" "2.700" "1" "1" "1" "1" "719" "81.8" "7.50" "2.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01429, Pf05033" "83852" "ENSG00000136169" "SETDB2" "hsa:83852; Q5TC65; Q5TC66; Q5W0A7; Q659A7; Q86UD6; Q96AI6; Q96T68" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670278986062403757" "False" "High" "IsMasterProtein" "P17050" "Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2" "0.005" "False" "2.683" "3" "1" "1" "1" "411" "46.5" "5.19" "2.95" "1" "other metabolic processes" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf16499, Pf17450" "4668" "ENSG00000198951" "NAGA" "hsa:4668; P17050" "" "" "0" "0" "1.385" "1.432" "1.175" "1.184" "1.192" "1.355" "1.521" "1.215" "1.240" "36.1" "50.0" "51.7" "42.4" "42.8" "43.0" "48.9" "54.9" "43.9" "44.8" "" "" "" "" "" "" "" "" "" "" "29.0" "36.1" "41.1" "28.4" "29.6" "32.3" "34.3" "40.1" "43.9" "36.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2935045971182124392" "False" "High" "IsMasterProtein" "Q7Z3E5" "LisH domain-containing protein ARMC9 OS=Homo sapiens OX=9606 GN=ARMC9 PE=1 SV=3" "0.005" "False" "2.680" "1" "1" "1" "1" "818" "91.8" "6.20" "2.56" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf21050, Pf21051" "80210" "ENSG00000135931" "ARMC9" "A0A087X1I8; hsa:80210; Q53TI3; Q6P162; Q7L594; Q7Z3E5; Q86WG2; Q96JF9; Q9H9R8" "" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848605729142375391" "False" "High" "IsMasterProtein" "P00813" "Adenosine deaminase OS=Homo sapiens OX=9606 GN=ADA PE=1 SV=3" "0.005" "False" "2.671" "2" "1" "1" "1" "363" "40.7" "5.95" "4.09" "1" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00962" "100" "ENSG00000196839" "ADA" "hsa:100; P00813; Q53F92; Q6LA59" "Ribavirin ADME; Purine salvage; Defective ADA disrupts (deoxy)adenosine deamination" "" "3" "0" "0.944" "0.949" "1.038" "1.078" "1.018" "0.972" "0.977" "1.025" "1.023" "334.1" "315.3" "317.0" "346.9" "360.2" "340.0" "324.7" "326.6" "342.5" "341.7" "" "" "" "" "" "" "" "" "" "" "268.4" "227.5" "251.8" "232.4" "249.1" "255.1" "227.3" "238.5" "342.5" "277.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1117159967779804568" "False" "High" "IsMasterProtein" "Q7L4I2" "Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1" "0.005" "False" "2.656" "4" "2" "3" "2" "434" "50.5" "11.33" "6.65" "2" "" "" "" "Pf15477" "65117" "ENSG00000111011" "RSRC2" "hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5114144552838835770" "False" "High" "IsMasterProtein" "Q8N196" "Homeobox protein SIX5 OS=Homo sapiens OX=9606 GN=SIX5 PE=1 SV=3" "0.005" "False" "2.646" "3" "2" "3" "1" "739" "74.5" "4.96" "6.55" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf16878" "147912" "ENSG00000177045" "SIX5" "hsa:147912; Q8N196" "" "" "0" "0" "1.030" "0.974" "1.089" "1.054" "0.952" "0.988" "1.102" "1.103" "1.028" "132.1" "136.1" "128.6" "143.8" "139.3" "125.7" "130.5" "145.6" "145.8" "135.8" "" "" "" "" "" "" "" "" "" "" "106.1" "98.2" "102.2" "96.4" "96.4" "94.3" "91.3" "106.3" "145.8" "110.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "948576377760285540" "False" "High" "IsMasterProtein" "Q5PRF9" "Protein Smaug homolog 2 OS=Homo sapiens OX=9606 GN=SAMD4B PE=1 SV=1" "0.005" "False" "2.642" "2" "2" "2" "2" "694" "75.4" "6.83" "2.07" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00536" "55095" "ENSG00000179134" "SAMD4B" "A5Z0M6; hsa:55095; Q5PRF9; Q6P194" "" "" "0" "0" "1.056" "1.093" "0.738" "1.112" "0.837" "1.293" "0.920" "1.131" "1.262" "32.7" "34.5" "35.7" "24.1" "36.3" "27.4" "42.3" "30.1" "37.0" "41.2" "" "" "" "" "" "" "" "" "" "" "26.2" "24.9" "28.4" "16.2" "25.1" "20.5" "29.6" "21.9" "37.0" "33.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1333795596038477477" "False" "High" "IsMasterProtein" "P62877" "E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1" "0.005" "False" "2.639" "7" "1" "1" "1" "108" "12.3" "6.96" "3.52" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9978" "ENSG00000100387" "RBX1" "B2RDY1; hsa:9978; P62877; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254" "Potential therapeutics for SARS; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; KEAP1-NFE2L2 pathway; Negative regulation of NOTCH4 signaling; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Degradation of DVL; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of BACH1 activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of TC-NER Pre-Incision Complex; Prolactin receptor signaling; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; Dual hijack model of Vif in HIV infection; TGF-beta signaling pathway; Type 2 papillary renal cell carcinoma; NRF2-ARE regulation; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Nucleotide excision repair; Hijack of ubiquitination by SARS-CoV-2; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 1p36 copy number variation syndrome" "48" "0" "1.048" "1.026" "0.948" "0.935" "1.071" "1.094" "1.049" "0.957" "1.005" "167.2" "175.3" "171.5" "158.6" "156.3" "179.2" "183.0" "175.5" "160.0" "168.0" "" "" "" "" "" "" "" "" "" "" "134.3" "126.5" "136.3" "106.2" "108.1" "134.4" "128.1" "128.2" "160.0" "136.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1301679656055029716" "False" "High" "IsMasterProtein" "Q9BWG6" "Sodium channel modifier 1 OS=Homo sapiens OX=9606 GN=SCNM1 PE=1 SV=1" "0.005" "False" "2.638" "4" "1" "1" "1" "230" "25.9" "8.87" "2.43" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15803, Pf15805" "100534012; 79005" "ENSG00000163156" "SCNM1" "B4DWR1; hsa:100534012; hsa:79005; Q5JR74; Q9BWG6" "" "" "0" "0" "1.232" "0.875" "0.986" "0.992" "1.001" "1.119" "1.062" "1.021" "0.909" "42.0" "51.8" "36.8" "41.4" "41.7" "42.1" "47.0" "44.6" "42.9" "38.2" "" "" "" "" "" "" "" "" "" "" "33.7" "37.4" "29.2" "27.8" "28.8" "31.6" "32.9" "32.6" "42.9" "31.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967759419043337591" "False" "High" "IsMasterProtein" "Q9UJ83" "2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2" "0.005" "False" "2.637" "2" "1" "1" "1" "578" "63.7" "7.36" "2.20" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "26061" "ENSG00000131373" "HACL1" "B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83" "Peroxisomal protein import; Alpha-oxidation of phytanate" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4689295707109511037" "False" "High" "IsMasterProtein" "O14610" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 OS=Homo sapiens OX=9606 GN=GNGT2 PE=1 SV=1" "0.005" "False" "2.633" "12" "1" "1" "1" "69" "7.7" "6.68" "3.14" "1" "signal transduction" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2793" "ENSG00000167083" "GNGT2" "B2R746; D3DTW5; hsa:2793; O14610" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits" "G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling" "32" "0" "0.978" "1.045" "0.994" "0.827" "1.025" "1.032" "0.884" "0.897" "0.988" "181.2" "177.2" "189.5" "180.1" "149.9" "185.8" "187.1" "160.3" "162.7" "179.2" "" "" "" "" "" "" "" "" "" "" "145.6" "127.9" "150.5" "120.7" "103.7" "139.4" "131.0" "117.1" "162.7" "145.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2822230476469774963" "False" "High" "IsMasterProtein" "P10415" "Apoptosis regulator Bcl-2 OS=Homo sapiens OX=9606 GN=BCL2 PE=1 SV=2" "0.005" "False" "2.630" "3" "1" "2" "1" "239" "26.2" "7.28" "4.89" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00452, Pf02180" "596" "ENSG00000171791" "BCL2" "C9JHD5; hsa:596; P10415; P10416; Q13842; Q16197" "Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; NFE2L2 regulating tumorigenic genes; Activation of BAD and translocation to mitochondria ; The NLRP1 inflammasome" "IL-5 signaling pathway; Influenza A virus infection; TP53 network; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Nanoparticle triggered autophagic cell death; Apoptosis; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Overview of nanoparticle effects; Photodynamic therapy-induced AP-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; Acute viral myocarditis; MicroRNA network associated with chronic lymphocytic leukemia; Measles virus infection; 22q11.2 copy number variation syndrome; Small cell lung cancer; Hepatitis B infection; Male infertility; Vitamin D-sensitive calcium signaling in depression; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Endoplasmic reticulum stress response in coronavirus infection; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; Unfolded protein response; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; GDNF signaling; Urotensin-II-mediated signaling pathway; Clock-controlled autophagy in bone metabolism; Hippocampal synaptogenesis and neurogenesis; TROP2 regulatory signaling; 10q11.21q11.23 copy number variation syndrome; NF1 copy number variation syndrome ; HDAC6 interactions in the central nervous system; DNA damage response (only ATM dependent); Estrogen signaling pathway" "59" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8222121445951017361" "False" "High" "IsMasterProtein" "Q9NS23" "Ras association domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RASSF1 PE=1 SV=1" "0.005" "False" "2.630" "3" "1" "1" "1" "344" "39.2" "8.97" "4.13" "1" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00130, Pf00788, Pf16517" "11186" "ENSG00000068028" "RASSF1" "B7ZLL1; hsa:11186; O14571; O60539; O60710; Q0VGC6; Q5TZT2; Q9HB04; Q9HB18; Q9NS22; Q9NS23; Q9UND4; Q9UND5" "" "Bladder cancer; Ras signaling; Non-small cell lung cancer; Hippo-YAP signaling; Pleural mesothelioma" "5" "0" "1.123" "1.105" "1.202" "1.143" "1.000" "1.024" "1.082" "1.081" "1.102" "204.9" "230.2" "226.5" "246.3" "234.3" "204.9" "209.9" "221.8" "221.4" "225.8" "" "" "" "" "" "" "" "" "" "" "164.6" "166.1" "179.9" "165.0" "162.0" "153.7" "146.9" "161.9" "221.4" "183.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8779201903022427655" "False" "High" "IsMasterProtein" "Q96JJ7" "Protein disulfide-isomerase TMX3 OS=Homo sapiens OX=9606 GN=TMX3 PE=1 SV=2" "0.005" "False" "2.629" "3" "1" "1" "1" "454" "51.8" "4.91" "2.14" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "54495" "ENSG00000166479" "TMX3" "B3KV75; hsa:54495; Q52LT7; Q8N5J0; Q96JJ7; Q9NWJ9" "Platelet degranulation" "" "1" "0" "1.156" "1.281" "1.502" "1.432" "1.690" "1.711" "1.630" "1.646" "1.516" "32.1" "37.2" "41.2" "48.3" "46.0" "54.3" "55.0" "52.4" "52.9" "48.7" "" "" "" "" "" "" "" "" "" "" "25.8" "26.8" "32.7" "32.4" "31.8" "40.8" "38.5" "38.3" "52.9" "39.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7336077529061589617" "False" "High" "IsMasterProtein" "Q9BUZ4" "TNF receptor-associated factor 4 OS=Homo sapiens OX=9606 GN=TRAF4 PE=1 SV=1" "0.005" "False" "2.625" "2" "1" "1" "1" "470" "53.5" "8.15" "3.12" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf21355" "9618" "ENSG00000076604" "TRAF4" "hsa:9618; O75615; Q14848; Q2KJU4; Q2PJN8; Q9BUZ4" "" "Small cell lung cancer; p53 transcriptional gene network" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994823038495086157" "False" "High" "IsMasterProtein" "Q02040" "A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2" "0.005" "False" "2.622" "2" "2" "2" "2" "695" "80.7" "9.73" "2.33" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "8227" "ENSG00000197976; ENSG00000292343" "AKAP17A" "hsa:8227; Q02040; Q02832; Q2TB98; Q5JQ74; Q5JQ76; Q8N6U9" "" "" "0" "0" "0.937" "1.263" "0.997" "1.233" "1.176" "1.309" "1.171" "1.329" "1.291" "54.5" "51.1" "68.8" "54.3" "67.2" "64.1" "71.3" "63.8" "72.5" "70.3" "" "" "" "" "" "" "" "" "" "" "43.8" "36.9" "54.7" "36.4" "46.5" "48.1" "50.0" "46.6" "72.5" "57.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776221742288509327" "False" "High" "IsMasterProtein" "O15060" "Zinc finger and BTB domain-containing protein 39 OS=Homo sapiens OX=9606 GN=ZBTB39 PE=1 SV=1" "0.005" "False" "2.621" "1" "1" "1" "1" "712" "79.0" "6.54" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "9880" "ENSG00000166860" "ZBTB39" "A7MD38; hsa:9880; O15060; Q9UD98" "" "" "0" "0" "1.029" "0.860" "1.135" "0.896" "0.683" "1.309" "1.084" "0.829" "1.259" "21.5" "22.1" "18.5" "24.4" "19.2" "14.7" "28.1" "23.3" "17.8" "27.0" "" "" "" "" "" "" "" "" "" "" "17.2" "15.9" "14.7" "16.3" "13.3" "11.0" "19.7" "17.0" "17.8" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015349167503174310" "False" "High" "IsMasterProtein" "Q8NCC3" "Lysosomal phospholipase A and acyltransferase OS=Homo sapiens OX=9606 GN=PLA2G15 PE=1 SV=2" "0.005" "False" "2.614" "3" "1" "1" "1" "412" "46.6" "6.73" "4.61" "1" "other metabolic processes" "non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02450" "23659" "ENSG00000103066" "PLA2G15" "B3KMF3; B4DUD1; hsa:23659; Q53GZ1; Q8NCC3; Q9NPQ6; Q9UG04; Q9Y2B3" "Hydrolysis of LPC" "" "1" "0" "1.077" "0.927" "1.141" "1.015" "0.963" "1.009" "0.914" "1.081" "0.836" "199.0" "214.3" "184.6" "227.1" "202.0" "191.7" "200.9" "181.9" "215.2" "166.5" "" "" "" "" "" "" "" "" "" "" "159.8" "154.6" "146.6" "152.2" "139.7" "143.8" "140.6" "132.8" "215.2" "135.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627710569246967084" "False" "High" "IsMasterProtein" "P11831" "Serum response factor OS=Homo sapiens OX=9606 GN=SRF PE=1 SV=1" "0.006" "False" "2.606" "2" "1" "1" "1" "508" "51.6" "8.10" "2.15" "1" "cell adhesion;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319" "6722" "ENSG00000112658" "SRF" "hsa:6722; P11831; Q5T648" "RHO GTPases Activate Formins; NGF-stimulated transcription; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Cardiogenesis; Regulation of NPAS4 gene transcription" "Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Genes targeted by miRNAs in adipocytes; Cell differentiation - expanded index; Cell differentiation - index; Mesodermal commitment pathway; Mesodermal commitment pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; PDGFR-beta pathway; Envelope proteins and their potential roles in EDMD physiopathology; 22q11.2 copy number variation syndrome; Insulin signaling; Orexin receptor pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "22" "0" "0.819" "0.874" "1.031" "0.952" "1.092" "0.949" "0.688" "0.877" "0.947" "55.9" "45.8" "48.9" "57.7" "53.2" "61.1" "53.0" "38.5" "49.0" "53.0" "" "" "" "" "" "" "" "" "" "" "44.9" "33.1" "38.8" "38.6" "36.8" "45.8" "37.1" "28.1" "49.0" "43.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5026099811254189140" "False" "High" "IsMasterProtein" "P11166" "Solute carrier family 2, facilitated glucose transporter member 1 OS=Homo sapiens OX=9606 GN=SLC2A1 PE=1 SV=2" "0.006" "False" "2.602" "2" "1" "1" "1" "492" "54.0" "8.72" "2.80" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00083" "6513" "ENSG00000117394" "SLC2A1" "A8K9S6; B2R620; D3DPX0; hsa:6513; O75535; P11166; Q0P512; Q147X2" "Cellular hexose transport; Regulation of insulin secretion; Vitamin C (ascorbate) metabolism; Lactose synthesis; Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Insulin signaling; Proximal tubule transport; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Amino acid metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Chronic hyperglycemia impairment of neuron function; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; Pancreatic cancer subtypes; 15q25 copy number variation; GLP-1 in pancreatic islet cells; GLP-1 from intestine and pancreas and role in glucose homeostasis" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1273704181858751884" "False" "High" "IsMasterProtein" "Q8N0X4" "Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2" "0.006" "False" "2.602" "3" "1" "1" "1" "340" "37.3" "8.73" "2.11" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "other molecular function" "Pf03328" "171425" "ENSG00000125246" "CLYBL" "hsa:171425; Q5W0F7; Q8N0X4; Q8TDH8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201817175006021" "False" "High" "IsMasterProtein" "Q96NL8" "Cilia- and flagella-associated protein 418 OS=Homo sapiens OX=9606 GN=CFAP418 PE=1 SV=1" "0.006" "False" "2.594" "4" "1" "1" "1" "207" "23.4" "6.95" "3.16" "1" "developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf14996" "157657" "ENSG00000156172" "CFAP418" "F4Y588; hsa:157657; Q96NL8" "" "Ciliopathies; Bardet-Biedl syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4676994035329171965" "False" "High" "IsMasterProtein" "Q14134" "Tripartite motif-containing protein 29 OS=Homo sapiens OX=9606 GN=TRIM29 PE=1 SV=2" "0.006" "False" "2.574" "2" "1" "2" "1" "588" "65.8" "7.15" "3.17" "1" "stress response;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf00643" "23650" "ENSG00000137699" "TRIM29" "hsa:23650; Q14134; Q96AA9; Q9BZY7" "Interferon gamma signaling" "Hematopoietic stem cell differentiation" "2" "0" "1.120" "0.906" "0.933" "0.957" "0.997" "0.852" "1.033" "0.907" "0.863" "113.9" "127.6" "103.1" "106.3" "109.0" "113.6" "97.0" "117.7" "103.3" "98.3" "" "" "" "" "" "" "" "" "" "" "91.5" "92.1" "81.9" "71.2" "75.4" "85.2" "67.9" "85.9" "103.3" "79.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637466038943732411" "False" "High" "IsMasterProtein" "Q5W111" "SPRY domain-containing protein 7 OS=Homo sapiens OX=9606 GN=SPRYD7 PE=1 SV=2" "0.006" "False" "2.562" "5" "1" "1" "1" "196" "21.7" "6.70" "2.80" "1" "" "" "" "Pf00622" "57213" "ENSG00000123178" "SPRYD7" "A8K3G1; hsa:57213; O60648; Q5W111; Q8TBG8; Q96T69" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "948534183126948466" "False" "High" "IsMasterProtein" "Q8IWE5" "Pleckstrin homology domain-containing family M member 2 OS=Homo sapiens OX=9606 GN=PLEKHM2 PE=1 SV=2" "0.006" "False" "2.560" "1" "1" "1" "1" "1019" "112.7" "4.93" "2.93" "1" "cell organization and biogenesis;stress response;other biological processes" "other membranes;other cytoplasmic organelle" "cytoskeletal activity" "Pf00169, Pf02759" "23207" "ENSG00000116786" "PLEKHM2" "O94928; Q5VT65; Q5VVD7; Q6NUH9; Q7L8G1; Q8IVT7; Q8IWE5; Q8N2T4; Q96AY0; Q9NTF7" "" "" "0" "0" "1.081" "1.011" "1.091" "0.977" "1.016" "1.157" "1.069" "1.088" "1.044" "158.4" "171.1" "160.1" "172.8" "154.8" "160.9" "183.3" "169.4" "172.3" "165.3" "" "" "" "" "" "" "" "" "" "" "127.2" "123.5" "127.2" "115.8" "107.1" "120.7" "128.3" "123.7" "172.3" "134.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7116132215439268199" "False" "High" "IsMasterProtein" "Q6ZRQ5" "Protein MMS22-like OS=Homo sapiens OX=9606 GN=MMS22L PE=1 SV=3" "0.006" "False" "2.558" "1" "1" "1" "1" "1243" "142.2" "7.12" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf14910, Pf14911" "253714" "ENSG00000146263" "MMS22L" "D6R9Y8; D6RBQ4; E1P529; hsa:253714; Q5THT2; Q68CQ6; Q68D32; Q6ZRQ5" "" "" "0" "0" "0.768" "1.043" "1.274" "0.759" "0.902" "1.104" "1.297" "1.125" "0.925" "15.3" "11.8" "16.0" "19.5" "11.7" "13.8" "16.9" "19.9" "17.3" "14.2" "" "" "" "" "" "" "" "" "" "" "12.3" "8.5" "12.7" "13.1" "8.1" "10.4" "11.9" "14.5" "17.3" "11.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-104196132274101736" "False" "High" "IsMasterProtein" "Q9GZT4" "Serine racemase OS=Homo sapiens OX=9606 GN=SRR PE=1 SV=1" "0.006" "False" "2.555" "3" "1" "1" "1" "340" "36.5" "6.54" "3.53" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00291" "63826" "ENSG00000167720" "SRR" "D3DTI5; hsa:63826; Q6IA55; Q9GZT4" "Serine biosynthesis" "Neuroinflammation and glutamatergic signaling" "2" "0" "1.122" "1.030" "1.201" "1.092" "1.020" "0.985" "1.103" "1.140" "1.173" "94.6" "106.2" "97.4" "113.6" "103.3" "96.5" "93.2" "104.4" "107.9" "111.0" "" "" "" "" "" "" "" "" "" "" "76.0" "76.6" "77.4" "76.1" "71.5" "72.4" "65.3" "76.2" "107.9" "90.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6412090478534982987" "False" "High" "IsMasterProtein" "Q9BVI0" "PHD finger protein 20 OS=Homo sapiens OX=9606 GN=PHF20 PE=1 SV=2" "0.006" "False" "2.550" "1" "1" "1" "1" "1012" "115.3" "6.99" "2.67" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12618, Pf18115, Pf20826" "51230" "ENSG00000025293" "PHF20" "A7E235; B2RB56; E1P5S3; hsa:51230; Q566Q2; Q5JWY9; Q66K49; Q9BVI0; Q9BWV4; Q9BXA3; Q9BZW3; Q9H421; Q9H4J6; Q9NZ22" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones; Regulation of TP53 Degradation; Stabilization of p53; Regulation of TP53 Activity through Association with Co-factors" "IL-18 signaling pathway" "6" "0" "1.030" "1.049" "1.054" "1.104" "1.036" "0.947" "1.068" "1.095" "0.959" "126.2" "130.0" "132.4" "133.1" "139.3" "130.7" "119.5" "134.8" "138.3" "121.0" "" "" "" "" "" "" "" "" "" "" "101.4" "93.8" "105.1" "89.2" "96.3" "98.1" "83.6" "98.4" "138.3" "98.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2679973573870526538" "False" "High" "IsMasterProtein" "P55347" "Homeobox protein PKNOX1 OS=Homo sapiens OX=9606 GN=PKNOX1 PE=1 SV=3" "0.006" "False" "2.547" "2" "1" "1" "1" "436" "47.6" "4.91" "3.13" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05920, Pf16493" "5316" "ENSG00000160199" "PKNOX1" "hsa:5316; O00528; P55347; Q8IWT7" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6635530035702083019" "False" "High" "IsMasterProtein" "Q68DK2" "Zinc finger FYVE domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZFYVE26 PE=1 SV=4" "0.006" "False" "2.543" "0" "1" "1" "1" "2539" "284.4" "6.39" "2.72" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "23503" "ENSG00000072121" "ZFYVE26" "B1B5Y3; B4E2U3; hsa:23503; O15035; Q68DK2; Q68DT9; Q6AW90; Q6ZR50; Q7Z3A4; Q7Z3I1; Q8N4W7; Q96H43" "" "" "0" "0" "1.404" "1.300" "1.091" "1.209" "1.424" "1.272" "1.110" "1.221" "1.214" "52.1" "73.2" "67.8" "56.8" "63.0" "74.2" "66.3" "57.9" "63.6" "63.3" "" "" "" "" "" "" "" "" "" "" "41.9" "52.8" "53.8" "38.1" "43.6" "55.7" "46.4" "42.3" "63.6" "51.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1789313073450950606" "False" "High" "IsMasterProtein" "Q9BSR8" "Protein YIPF4 OS=Homo sapiens OX=9606 GN=YIPF4 PE=1 SV=1" "0.006" "False" "2.534" "4" "1" "1" "1" "244" "27.1" "4.65" "3.43" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf04893" "84272" "ENSG00000119820" "YIPF4" "hsa:84272; Q9BSR8" "" "" "0" "0" "1.117" "0.918" "1.113" "1.104" "0.969" "1.048" "1.074" "0.922" "1.103" "137.4" "153.4" "126.2" "152.9" "151.8" "133.1" "144.0" "147.6" "126.7" "151.6" "" "" "" "" "" "" "" "" "" "" "110.4" "110.7" "100.2" "102.5" "105.0" "99.9" "100.8" "107.8" "126.7" "123.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7751322844419777287" "False" "High" "IsMasterProtein" "P33121" "Long-chain-fatty-acid--CoA ligase 1 OS=Homo sapiens OX=9606 GN=ACSL1 PE=1 SV=1" "0.006" "False" "2.518" "2" "1" "1" "1" "698" "77.9" "7.15" "2.05" "1" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00501" "2180" "ENSG00000151726" "ACSL1" "B7Z452; D3DP57; hsa:2180; P33121; P41215; Q8N8V7; Q8TA99" "PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders; Fatty acids and lipoproteins transport in hepatocytes; Cholesterol biosynthesis pathway in hepatocytes" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "775104918655052520" "False" "High" "IsMasterProtein" "Q9H8X2" "Inositol-pentakisphosphate 2-kinase OS=Homo sapiens OX=9606 GN=IPPK PE=1 SV=1" "0.006" "False" "2.513" "2" "1" "1" "1" "491" "56.0" "8.37" "2.65" "1" "other metabolic processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06090" "64768" "ENSG00000127080" "IPPK" "hsa:64768; Q5T9F7; Q9H7V8; Q9H8X2" "Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus" "" "2" "0" "0.893" "0.854" "1.184" "0.919" "0.969" "1.130" "1.115" "1.170" "1.033" "71.5" "63.8" "61.1" "84.6" "65.7" "69.3" "80.7" "79.7" "83.6" "73.8" "" "" "" "" "" "" "" "" "" "" "57.4" "46.0" "48.5" "56.7" "45.4" "52.0" "56.5" "58.2" "83.6" "60.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366730786778732406" "False" "High" "IsMasterProtein" "Q9UKB3" "DnaJ homolog subfamily C member 12 OS=Homo sapiens OX=9606 GN=DNAJC12 PE=1 SV=1" "0.006" "False" "2.506" "5" "1" "1" "1" "198" "23.4" "5.71" "2.86" "1" "" "other cell component" "" "Pf00226" "56521" "ENSG00000108176" "DNAJC12" "hsa:56521; Q5JVQ1; Q9UKB2; Q9UKB3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-6222796260561926749" "False" "High" "IsMasterProtein" "Q9NXW2" "DnaJ homolog subfamily B member 12 OS=Homo sapiens OX=9606 GN=DNAJB12 PE=1 SV=5" "0.006" "False" "2.500" "2" "1" "1" "1" "375" "41.8" "8.69" "2.53" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00226, Pf09320" "54788" "ENSG00000148719" "DNAJB12" "B7Z7I3; hsa:54788; Q9H6H0; Q9NXW2" "" "" "0" "0" "0.866" "0.879" "1.060" "0.964" "1.171" "0.997" "0.976" "1.058" "1.120" "33.0" "28.5" "29.0" "35.0" "31.8" "38.6" "32.9" "32.2" "34.9" "36.9" "" "" "" "" "" "" "" "" "" "" "26.5" "20.6" "23.0" "23.4" "22.0" "29.0" "23.0" "23.5" "34.9" "30.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2188123927045547815" "False" "High" "IsMasterProtein" "P51790" "H(+)/Cl(-) exchange transporter 3 OS=Homo sapiens OX=9606 GN=CLCN3 PE=1 SV=2" "0.006" "False" "2.497" "1" "1" "1" "1" "818" "90.9" "6.28" "2.81" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00571, Pf00654" "1182" "ENSG00000109572" "CLCN3" "B7Z932; B9EGJ9; D3DP34; E9PB97; hsa:1182; O14918; P51790; Q86Z21" "Stimuli-sensing channels" "TAR syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209502681101224333" "False" "High" "IsMasterProtein" "Q9NV96" "Cell cycle control protein 50A OS=Homo sapiens OX=9606 GN=TMEM30A PE=1 SV=1" "0.006" "False" "2.496" "2" "1" "1" "1" "361" "40.7" "8.59" "3.04" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03381" "55754" "ENSG00000112697" "TMEM30A" "A8K9V8; E1P539; hsa:55754; Q658Z3; Q96H09; Q9NSL9; Q9NV96" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2700205746988469597" "False" "High" "IsMasterProtein" "O94892" "Zinc finger protein 432 OS=Homo sapiens OX=9606 GN=ZNF432 PE=1 SV=1" "0.006" "False" "2.487" "4" "2" "2" "2" "652" "74.8" "8.75" "0.00" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "9668" "ENSG00000256087" "ZNF432" "hsa:9668; O94892" "Generic Transcription Pathway" "" "1" "0" "1.028" "0.883" "0.894" "0.684" "0.902" "0.697" "0.655" "0.742" "0.768" "80.2" "82.4" "70.8" "71.7" "54.9" "72.4" "55.9" "52.5" "59.5" "61.6" "" "" "" "" "" "" "" "" "" "" "64.4" "59.5" "56.2" "48.0" "37.9" "54.3" "39.1" "38.3" "59.5" "50.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8411894831205011543" "False" "High" "IsMasterProtein" "Q7L8J4" "SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1" "0.006" "False" "2.481" "2" "1" "1" "1" "393" "43.5" "5.77" "2.69" "1" "signal transduction" "other cell component" "enzyme regulator activity" "Pf05276" "80851" "ENSG00000175137" "SH3BP5L" "B4DQ94; hsa:80851; Q7L8J4; Q96FI5; Q9BQH8; Q9C0E3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115574768027660471" "False" "High" "IsMasterProtein" "P30837" "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=4" "0.006" "False" "2.474" "2" "1" "1" "1" "517" "57.2" "6.99" "3.28" "1" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00171" "219" "ENSG00000137124" "ALDH1B1" "B2R8F0; hsa:219; P30837; Q8WX76; Q9BV45" "Mitochondrial protein degradation; Ethanol oxidation" "" "2" "0" "1.087" "1.118" "1.134" "1.293" "1.018" "1.103" "1.066" "1.084" "1.083" "221.5" "240.8" "247.6" "251.3" "286.3" "225.4" "244.3" "236.2" "240.1" "239.8" "" "" "" "" "" "" "" "" "" "" "177.9" "173.7" "196.7" "168.3" "198.0" "169.1" "171.0" "172.5" "240.1" "195.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "756136000491077603" "False" "High" "IsMasterProtein" "P08236" "Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2" "0.006" "False" "2.467" "2" "2" "3" "2" "651" "74.7" "7.02" "6.95" "2" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00703, Pf02836, Pf02837" "2990" "ENSG00000169919" "GUSB" "B4E1F6; E9PCV0; hsa:2990; P08236; Q549U0; Q96CL9" "Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation; MPS VII - Sly syndrome" "Glycosaminoglycan degradation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1413816697731650822" "False" "High" "IsMasterProtein" "Q9BU64" "Centromere protein O OS=Homo sapiens OX=9606 GN=CENPO PE=1 SV=1" "0.006" "False" "2.465" "3" "1" "1" "1" "300" "33.8" "7.71" "3.27" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf09496" "79172" "ENSG00000138092" "CENPO" "B2RDC0; D6W536; hsa:79172; Q53T55; Q96JV3; Q9BU64" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "33731746096027930" "False" "High" "IsMasterProtein" "Q8TC12" "Retinol dehydrogenase 11 OS=Homo sapiens OX=9606 GN=RDH11 PE=1 SV=2" "0.006" "False" "2.463" "4" "1" "1" "1" "318" "35.4" "8.82" "2.03" "1" "other metabolic processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00106" "51109" "ENSG00000072042" "RDH11" "A6NDK3; A8K062; B2RB26; B4DDW0; hsa:51109; Q0QD40; Q6IAH5; Q8TC12; Q9NRW0; Q9Y391" "RA biosynthesis pathway; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1754364891435956816" "False" "High" "IsMasterProtein" "Q8NG68" "Tubulin--tyrosine ligase OS=Homo sapiens OX=9606 GN=TTL PE=1 SV=2" "0.006" "False" "2.462" "2" "1" "1" "1" "377" "43.2" "6.74" "2.96" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton" "other molecular function" "Pf03133" "150465" "ENSG00000114999" "TTL" "hsa:150465; Q585T3; Q7Z302; Q8N426; Q8NG68" "Carboxyterminal post-translational modifications of tubulin" "2q13 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8364917298053465575" "False" "High" "IsMasterProtein" "Q9UQ88" "Cyclin-dependent kinase 11A OS=Homo sapiens OX=9606 GN=CDK11A PE=1 SV=4" "0.006" "False" "2.457" "1" "1" "1" "1" "783" "91.3" "5.36" "2.68" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "728642" "ENSG00000008128" "CDK11A" "hsa:728642; O95227; O95228; O96012; Q12821; Q12853; Q12854; Q2TAJ0; Q5QPR0; Q5QPR1; Q5QPR2; Q9UBC4; Q9UBI3; Q9UEI1; Q9UEI2; Q9UP53; Q9UP54; Q9UP55; Q9UP56; Q9UQ86; Q9UQ87; Q9UQ88; Q9UQ89" "Recruitment of mitotic centrosome proteins and complexes" "1p36 copy number variation syndrome" "2" "0" "0.963" "1.133" "0.880" "1.005" "0.771" "1.020" "0.940" "0.923" "1.172" "52.4" "50.5" "59.4" "46.1" "52.7" "40.4" "53.4" "49.2" "48.3" "61.4" "" "" "" "" "" "" "" "" "" "" "42.1" "36.4" "47.2" "30.9" "36.4" "30.3" "37.4" "35.9" "48.3" "49.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516940427401881470" "False" "High" "IsMasterProtein" "Q13615" "Myotubularin-related protein 3 OS=Homo sapiens OX=9606 GN=MTMR3 PE=1 SV=3" "0.006" "False" "2.457" "1" "1" "1" "1" "1198" "133.5" "5.80" "2.89" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf01363, Pf06602" "8897" "ENSG00000100330" "MTMR3" "A5PL26; A7MD32; hsa:8897; Q13615; Q9NYN5; Q9NYN6; Q9UDX6; Q9UEG3" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1089624878569617395" "False" "High" "IsMasterProtein" "Q9NW61" "Pleckstrin homology domain-containing family J member 1 OS=Homo sapiens OX=9606 GN=PLEKHJ1 PE=1 SV=1" "0.006" "False" "2.448" "10" "1" "1" "1" "149" "17.5" "7.84" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;ER/Golgi;other cytoplasmic organelle" "" "Pf00169" "55111" "ENSG00000104886" "PLEKHJ1" "B3KUQ9; D6W604; hsa:55111; Q9NW61" "" "" "0" "0" "0.932" "0.942" "0.965" "1.065" "1.132" "0.862" "0.947" "0.944" "1.097" "154.7" "144.2" "145.7" "149.3" "164.7" "175.1" "133.3" "146.5" "146.1" "169.7" "" "" "" "" "" "" "" "" "" "" "124.2" "104.0" "115.8" "100.0" "113.9" "131.4" "93.3" "107.0" "146.1" "138.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1696435986512239972" "False" "High" "IsMasterProtein" "A6NF36" "Coiled-coil domain-containing protein 182 OS=Homo sapiens OX=9606 GN=CCDC182 PE=1 SV=1" "0.006" "False" "2.445" "9" "2" "2" "1" "153" "17.5" "6.58" "1.99" "2" "developmental processes" "" "" "Pf15835" "101927581" "ENSG00000166329" "CCDC182" "A6NF36; hsa:101927581" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4402590464263021312" "False" "High" "IsMasterProtein" "Q9Y483" "Metal-response element-binding transcription factor 2 OS=Homo sapiens OX=9606 GN=MTF2 PE=1 SV=3" "0.006" "False" "2.444" "2" "1" "1" "1" "593" "67.0" "8.75" "2.94" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf14061, Pf18104" "22823" "ENSG00000143033" "MTF2" "A6NGQ9; A8K2Q3; B1AKT5; B1AKT6; hsa:22823; Q96G26; Q9UES9; Q9UP40; Q9Y483" "PRC2 methylates histones and DNA" "Mesodermal commitment pathway; Interactome of polycomb repressive complex 2 (PRC2) ; Copper homeostasis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2271404358644786379" "False" "High" "IsMasterProtein" "P46778" "Large ribosomal subunit protein eL21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2" "0.006" "False" "2.442" "7" "1" "1" "1" "160" "18.6" "10.49" "0.00" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf01157" "6144" "ENSG00000122026" "RPL21" "hsa:6144; P46778; Q16699" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726874923115872631" "False" "High" "IsMasterProtein" "Q13569" "G/T mismatch-specific thymine DNA glycosylase OS=Homo sapiens OX=9606 GN=TDG PE=1 SV=2" "0.006" "False" "2.431" "3" "1" "1" "1" "410" "46.0" "6.80" "1.67" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03167" "6996" "ENSG00000139372" "TDG" "hsa:6996; Q13569; Q8IUZ6; Q8IZM3" "SUMOylation of DNA damage response and repair proteins; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1; TET1,2,3 and TDG demethylate DNA" "Fluoropyrimidine activity; Base excision repair; DNA repair pathways, full network" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8991968867262954800" "False" "High" "IsMasterProtein" "Q9P2K8" "eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3" "0.006" "False" "2.427" "0" "1" "1" "1" "1649" "186.8" "6.28" "2.72" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf05773, Pf12745, Pf13393" "440275" "ENSG00000128829" "EIF2AK4" "C9JEC4; hsa:440275; Q69YL7; Q6DC97; Q96GN6; Q9H5K1; Q9NSQ3; Q9NSZ5; Q9P2K8; Q9UJ56" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "Measles virus infection" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1822880503447006764" "False" "High" "IsMasterProtein" "Q9NX04" "AFG2-interacting ribosome maturation factor OS=Homo sapiens OX=9606 GN=AIRIM PE=1 SV=1" "0.006" "False" "2.426" "4" "1" "1" "1" "203" "23.4" "5.67" "2.97" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf15011" "54955" "ENSG00000116922" "AIRIM" "D3DPT1; Q8WVD1; Q9NX04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5595867341215440863" "False" "High" "IsMasterProtein" "Q6ZU65" "Ubinuclein-2 OS=Homo sapiens OX=9606 GN=UBN2 PE=1 SV=2" "0.006" "False" "2.416" "1" "1" "1" "1" "1347" "146.0" "9.19" "2.66" "1" "" "nucleus" "" "Pf08729, Pf14075" "254048" "ENSG00000157741" "UBN2" "A4D1S2; hsa:254048; Q2YDY4; Q6P1K0; Q6ZU65; Q86XN9; Q8N7D1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623340480838481175" "False" "High" "IsMasterProtein" "Q15287" "RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1" "0.006" "False" "2.414" "5" "1" "1" "1" "305" "34.2" "11.84" "1.83" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10921" "ENSG00000205937" "RNPS1" "A8K1P0; B4DDU8; B4DZU7; B7ZA17; hsa:10921; O75308; Q15287; Q32P25; Q8WY42; Q9NYG3" "Transport of Mature mRNA derived from an Intron-Containing Transcript; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "7" "0" "0.830" "0.962" "0.769" "0.939" "0.878" "0.949" "0.734" "0.980" "0.821" "352.1" "292.3" "338.8" "270.6" "330.6" "309.1" "334.2" "258.3" "345.2" "289.1" "" "" "" "" "" "" "" "" "" "" "282.8" "210.9" "269.1" "181.3" "228.7" "231.9" "234.0" "188.6" "345.2" "235.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1638288113087067454" "False" "High" "IsMasterProtein" "Q9NQG6" "Mitochondrial dynamics protein MIEF1 OS=Homo sapiens OX=9606 GN=MIEF1 PE=1 SV=1" "0.006" "False" "2.407" "2" "1" "1" "1" "463" "51.3" "7.64" "2.54" "1" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf20266, Pf21297" "54471" "ENSG00000100335" "MIEF1" "hsa:54471; Q7L890; Q9BUI3; Q9NQG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7170816328475154252" "False" "High" "IsMasterProtein" "Cont_Q2KJF1" "Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1" "0.006" "True" "2.402" "5" "1" "1" "1" "503" "53.5" "5.43" "0.00" "1" "" "non-structural extracellular;plasma membrane;other membranes" "" "Pf00047" "518955" "ENSBTAG00000009735" "A1BG" "bta:518955; Q2KJF1" "Neutrophil degranulation; Platelet degranulation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "High" "Not Found" "High" "Not Found" "1" "" "-7022499983038261226" "False" "High" "IsMasterProtein" "Q1ED39" "Lysine-rich nucleolar protein 1 OS=Homo sapiens OX=9606 GN=KNOP1 PE=1 SV=1" "0.006" "False" "2.395" "2" "1" "1" "1" "458" "51.6" "9.86" "2.88" "1" "" "nucleus" "" "Pf15477" "400506" "ENSG00000103550" "KNOP1" "O43328; Q1ED39; Q5FWF3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822913707672992283" "False" "High" "IsMasterProtein" "Q9NPH0" "Lysophosphatidic acid phosphatase type 6 OS=Homo sapiens OX=9606 GN=ACP6 PE=1 SV=3" "0.006" "False" "2.395" "3" "1" "1" "1" "428" "48.9" "6.47" "2.24" "1" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00328" "51205" "ENSG00000162836" "ACP6" "hsa:51205; Q59G61; Q5T490; Q6IAQ3; Q7LG81; Q9NPH0; Q9UIG6; X5D289" "Synthesis of PA" "1q21.1 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5711081481514943927" "False" "High" "IsMasterProtein" "P07858" "Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3" "0.006" "False" "2.394" "2" "1" "1" "1" "339" "37.8" "6.30" "2.92" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112, Pf08127" "1508" "ENSG00000164733; ENSG00000285132" "CTSB" "B3KQR5; B3KRR5; hsa:1508; P07858; Q503A6; Q96D87" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR" "Ebola virus infection in host; 8p23.1 copy number variation syndrome" "7" "0" "1.163" "0.945" "1.166" "1.118" "0.983" "1.014" "1.043" "1.094" "1.020" "122.7" "142.7" "115.9" "143.2" "137.2" "120.6" "124.4" "128.0" "134.2" "125.2" "" "" "" "" "" "" "" "" "" "" "98.6" "103.0" "92.1" "95.9" "94.9" "90.5" "87.1" "93.5" "134.2" "101.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781078747776304120" "False" "High" "IsMasterProtein" "Q9NY12" "H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1" "0.006" "False" "2.381" "4" "1" "1" "1" "217" "22.3" "10.92" "1.66" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf04410" "54433" "ENSG00000109534" "GAR1" "hsa:54433; Q5MJQ2; Q9NY12" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "1.635" "1.507" "1.551" "1.475" "1.816" "1.175" "1.437" "1.371" "1.442" "10.1" "16.4" "15.2" "15.6" "14.8" "18.3" "11.8" "14.4" "13.8" "14.5" "" "" "" "" "" "" "" "" "" "" "8.1" "11.9" "12.0" "10.5" "10.3" "13.7" "8.3" "10.5" "13.8" "11.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6341136208215643454" "False" "High" "IsMasterProtein" "Q6GYQ0" "Ral GTPase-activating protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=RALGAPA1 PE=1 SV=1" "0.006" "False" "2.381" "1" "2" "2" "2" "2036" "229.7" "6.19" "1.89" "2" "other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf20412" "253959" "ENSG00000174373" "RALGAPA1" "A6NMA4; B9EK38; C5NU19; hsa:253959; O94960; Q6GYP9; Q6GYQ0; Q6ZT23; Q86YF3; Q86YF5; Q8ND69" "RHOH GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2551406606106845591" "False" "High" "IsMasterProtein" "Q13127" "RE1-silencing transcription factor OS=Homo sapiens OX=9606 GN=REST PE=1 SV=3" "0.006" "False" "2.379" "1" "1" "1" "1" "1097" "121.8" "6.74" "2.48" "1" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "5978" "ENSG00000084093" "REST" "A2RUE0; B9EGJ0; hsa:5978; Q12956; Q12957; Q13127; Q13134; Q59ER1; Q8IWI3" "HDACs deacetylate histones; Potential therapeutics for SARS; NGF-stimulated transcription; Regulation of PTEN gene transcription; Regulation of NPAS4 gene transcription" "MECP2 and associated Rett syndrome; DYRK1A involvement regarding cell proliferation in brain development; 11p11.2 copy number variation syndrome ; Sudden infant death syndrome (SIDS) susceptibility pathways" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2387903183382251234" "False" "High" "IsMasterProtein" "P0C1Z6" "TCF3 fusion partner OS=Homo sapiens OX=9606 GN=TFPT PE=1 SV=1" "0.006" "False" "2.377" "3" "1" "1" "1" "253" "28.3" "5.21" "2.46" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "29844" "ENSG00000105619; ENSG00000273833; ENSG00000274073; ENSG00000275086; ENSG00000276022; ENSG00000276263; ENSG00000276296; ENSG00000276323; ENSG00000276504; ENSG00000278161" "TFPT" "G5E9B5; hsa:29844; P0C1Z6" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "1.259" "1.206" "1.157" "1.216" "1.023" "1.247" "1.130" "1.030" "0.868" "47.9" "60.3" "57.7" "55.4" "58.2" "49.0" "59.7" "54.1" "49.3" "41.6" "" "" "" "" "" "" "" "" "" "" "38.5" "43.5" "45.9" "37.1" "40.3" "36.8" "41.8" "39.5" "49.3" "33.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9094394265739155488" "False" "High" "IsMasterProtein" "O75132" "Zinc finger BED domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZBED4 PE=1 SV=2" "0.006" "False" "2.375" "1" "1" "1" "1" "1171" "130.2" "6.83" "2.68" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892, Pf05699" "9889" "ENSG00000100426" "ZBED4" "B2RZH1; hsa:9889; O75132; Q1ECU0; Q9UGG8" "" "" "0" "0" "0.967" "0.949" "1.224" "1.168" "1.043" "1.099" "1.000" "1.073" "1.110" "100.6" "97.3" "95.5" "123.2" "117.6" "104.9" "110.6" "100.7" "108.0" "111.7" "" "" "" "" "" "" "" "" "" "" "80.8" "70.2" "75.8" "82.5" "81.3" "78.7" "77.4" "73.5" "108.0" "90.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2564730176707544032" "False" "High" "IsMasterProtein" "O95479" "GDH/6PGL endoplasmic bifunctional protein OS=Homo sapiens OX=9606 GN=H6PD PE=1 SV=2" "0.007" "False" "2.369" "1" "1" "1" "1" "791" "88.8" "7.30" "2.82" "1" "other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf00479, Pf01182, Pf02781" "9563" "ENSG00000049239" "H6PD" "hsa:9563; O95479; Q4TT33; Q66I35; Q68DT3; R4GMU1" "" "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism" "1" "0" "1.009" "0.914" "1.068" "0.935" "1.063" "1.169" "1.115" "1.106" "1.007" "50.3" "50.7" "45.9" "53.7" "47.0" "53.4" "58.7" "56.0" "55.6" "50.6" "" "" "" "" "" "" "" "" "" "" "40.4" "36.6" "36.5" "36.0" "32.5" "40.1" "41.1" "40.9" "55.6" "41.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-394911082341009184" "False" "High" "IsMasterProtein" "Q4G0S7" "Coiled-coil domain-containing protein 152 OS=Homo sapiens OX=9606 GN=CCDC152 PE=1 SV=3" "0.007" "False" "2.364" "3" "1" "2" "1" "254" "30.0" "9.06" "3.89" "1" "" "" "" "" "100129792" "ENSG00000198865" "CCDC152" "B3KXI4; B4E0P7; hsa:100129792; Q4G0S7; Q5BLP6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5733172481580035365" "False" "High" "IsMasterProtein" "A5LHX3" "Proteasome subunit beta type-11 OS=Homo sapiens OX=9606 GN=PSMB11 PE=1 SV=1" "0.007" "False" "2.355" "5" "1" "1" "1" "300" "32.5" "6.46" "3.00" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "122706" "ENSG00000222028" "PSMB11" "A5LHX3; hsa:122706" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "" "52" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7848272744122978575" "False" "High" "IsMasterProtein" "Q8N283" "Ankyrin repeat domain-containing protein 35 OS=Homo sapiens OX=9606 GN=ANKRD35 PE=1 SV=3" "0.007" "False" "2.347" "2" "1" "2" "1" "1001" "109.9" "6.02" "0.00" "1" "" "" "cytoskeletal activity" "Pf12796" "148741" "ENSG00000198483" "ANKRD35" "A6NEU0; B4DL62; hsa:148741; Q3MJ10; Q8N283; Q96LS3" "" "TAR syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3567391987631389580" "False" "High" "IsMasterProtein" "Q9BZA7" "Protocadherin-11 X-linked OS=Homo sapiens OX=9606 GN=PCDH11X PE=1 SV=1" "0.008" "False" "2.336" "1" "1" "2" "1" "1347" "147.5" "5.21" "2.28" "1" "cell adhesion" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf08374" "27328" "ENSG00000102290" "PCDH11X" "A6NIQ4; hsa:27328; Q2TJH0; Q2TJH1; Q2TJH3; Q5JVZ0; Q70LR8; Q70LS7; Q70LS8; Q70LS9; Q70LT7; Q70LT8; Q70LT9; Q70LU0; Q70LU1; Q96RV4; Q96RW0; Q9BZA6; Q9BZA7; Q9H4E0; Q9P2M0; Q9P2X5" "" "" "0" "0" "1.012" "1.077" "0.833" "0.772" "0.706" "0.687" "0.993" "0.879" "0.828" "255.8" "258.9" "275.6" "213.1" "197.6" "180.6" "175.8" "254.1" "224.9" "211.9" "" "" "" "" "" "" "" "" "" "" "205.5" "186.8" "218.9" "142.8" "136.7" "135.5" "123.1" "185.5" "224.9" "172.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4126622846664947622" "False" "High" "IsMasterProtein" "Q96H35" "Probable RNA-binding protein 18 OS=Homo sapiens OX=9606 GN=RBM18 PE=1 SV=1" "0.008" "False" "2.328" "13" "1" "1" "1" "190" "21.6" "9.44" "0.00" "1" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "92400" "ENSG00000119446" "RBM18" "B3KQ89; hsa:92400; Q96H35" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2019204481334339745" "False" "High" "IsMasterProtein" "Q9H3R0" "Lysine-specific demethylase 4C OS=Homo sapiens OX=9606 GN=KDM4C PE=1 SV=2" "0.008" "False" "2.316" "1" "1" "1" "1" "1056" "119.9" "6.46" "2.33" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "23081" "ENSG00000107077" "KDM4C" "B4E1Y4; B7ZL46; F5H347; F5H7P0; hsa:23081; O94877; Q2M3M0; Q5JUC9; Q5VYJ2; Q5VYJ3; Q9H3R0" "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; HDMs demethylate histones" "" "2" "0" "0.954" "1.049" "1.188" "1.172" "0.969" "0.921" "0.917" "1.125" "0.959" "56.4" "53.9" "59.2" "67.1" "66.2" "54.7" "52.0" "51.7" "63.5" "54.1" "" "" "" "" "" "" "" "" "" "" "45.3" "38.9" "47.0" "44.9" "45.8" "41.0" "36.4" "37.8" "63.5" "44.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4527402495997135849" "False" "High" "IsMasterProtein" "Q08AG7" "Mitotic-spindle organizing protein 1 OS=Homo sapiens OX=9606 GN=MZT1 PE=1 SV=2" "0.008" "False" "2.306" "13" "1" "1" "1" "82" "8.5" "4.78" "2.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf12554" "440145" "ENSG00000204899" "MZT1" "hsa:440145; Q08AG7; Q5W0P5" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "" "2" "0" "1.055" "1.042" "1.108" "1.105" "1.098" "1.009" "1.013" "0.942" "0.977" "154.5" "163.0" "161.0" "171.2" "170.7" "169.7" "155.9" "156.6" "145.5" "150.9" "" "" "" "" "" "" "" "" "" "" "124.1" "117.6" "127.9" "114.7" "118.1" "127.3" "109.1" "114.3" "145.5" "122.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6750533820938238159" "False" "High" "IsMasterProtein" "O75943" "Cell cycle checkpoint protein RAD17 OS=Homo sapiens OX=9606 GN=RAD17 PE=1 SV=2" "0.008" "False" "2.302" "1" "1" "1" "1" "681" "77.0" "7.06" "2.87" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03215" "5884" "ENSG00000152942; ENSG00000276618" "RAD17" "A8K8X2; D3DWA5; hsa:5884; O75714; O75943; Q7Z3S4; Q9UNK7; Q9UNR7; Q9UNR8; Q9UPF5" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response" "10" "0" "0.945" "0.808" "0.930" "0.982" "1.004" "0.833" "0.940" "0.805" "1.025" "80.0" "75.6" "64.6" "74.4" "78.5" "80.3" "66.6" "75.2" "64.4" "82.0" "" "" "" "" "" "" "" "" "" "" "64.2" "54.5" "51.3" "49.8" "54.3" "60.3" "46.6" "54.9" "64.4" "66.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6315977930772822747" "False" "High" "IsMasterProtein" "Q9Y3C7" "Mediator of RNA polymerase II transcription subunit 31 OS=Homo sapiens OX=9606 GN=MED31 PE=1 SV=1" "0.008" "False" "2.301" "5" "1" "1" "1" "131" "15.8" "8.54" "3.08" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05669" "51003" "ENSG00000108590" "MED31" "B2R4L9; hsa:51003; Q9Y3C7" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway; RSV-host interactions" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9027180669727079194" "False" "High" "IsMasterProtein" "Q5T280" "Putative methyltransferase C9orf114 OS=Homo sapiens OX=9606 GN=SPOUT1 PE=1 SV=3" "0.008" "False" "2.300" "2" "1" "1" "1" "376" "42.0" "7.43" "2.36" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "nucleic acid binding activity;other molecular function" "Pf02598" "51490" "ENSG00000198917" "SPOUT1" "hsa:51490; Q0D2P6; Q5T280; Q6P469; Q6PGP9; Q6PIJ1; Q6PJV9" "" "" "0" "0" "0.957" "1.162" "0.941" "1.105" "1.005" "1.128" "1.034" "0.973" "0.952" "66.3" "63.4" "77.0" "62.4" "73.2" "66.6" "74.8" "68.5" "64.5" "63.1" "" "" "" "" "" "" "" "" "" "" "53.2" "45.8" "61.2" "41.8" "50.6" "50.0" "52.4" "50.0" "64.5" "51.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2215579881397613595" "False" "High" "IsMasterProtein" "P35716" "Transcription factor SOX-11 OS=Homo sapiens OX=9606 GN=SOX11 PE=1 SV=2" "0.008" "False" "2.299" "2" "1" "1" "1" "441" "46.7" "5.05" "3.13" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6664" "ENSG00000176887" "SOX11" "hsa:6664; P35716; Q4ZFV8" "" "Pre-implantation embryo; GDNF/RET signaling axis" "2" "0" "0.746" "1.294" "1.005" "0.973" "0.946" "1.101" "0.916" "1.047" "1.112" "218.0" "162.7" "282.1" "219.1" "212.0" "206.3" "240.0" "199.8" "228.2" "242.5" "" "" "" "" "" "" "" "" "" "" "175.1" "117.4" "224.0" "146.8" "146.6" "154.8" "168.0" "145.9" "228.2" "197.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697470728296879820" "False" "High" "IsMasterProtein" "Q9NNX9" "Variable charge X-linked protein 3 OS=Homo sapiens OX=9606 GN=VCX3A PE=2 SV=1" "0.008" "False" "2.293" "6" "1" "1" "1" "186" "20.0" "4.49" "2.09" "1" "developmental processes" "nucleus" "" "Pf15231" "51481" "ENSG00000169059" "VCX3A" "hsa:51481; Q9NNX9; Q9P0H4" "" "" "0" "0" "1.226" "1.162" "0.838" "1.173" "1.329" "1.348" "1.172" "1.309" "1.021" "19.8" "24.3" "23.1" "16.6" "23.3" "26.4" "26.8" "23.3" "26.0" "20.3" "" "" "" "" "" "" "" "" "" "" "15.9" "17.6" "18.3" "11.1" "16.1" "19.8" "18.7" "17.0" "26.0" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5759218457056628975" "False" "High" "IsMasterProtein" "Q6NVH7" "ATPase SWSAP1 OS=Homo sapiens OX=9606 GN=SWSAP1 PE=1 SV=1" "0.008" "False" "2.290" "4" "1" "1" "1" "229" "24.3" "5.21" "2.23" "1" "DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "126074" "ENSG00000173928" "SWSAP1" "hsa:126074; Q6NVH7; Q8NAM1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6133678444779992417" "False" "High" "IsMasterProtein" "Q9UGU0" "Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3" "0.008" "False" "2.283" "0" "1" "1" "1" "1960" "211.6" "9.04" "3.24" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13771" "6942" "ENSG00000100207; ENSG00000262024; ENSG00000276461" "TCF20" "A9JX12; hsa:6942; O14528; Q13078; Q4V353; Q9H4M0; Q9UGU0" "" "Matrix metalloproteinases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3574158792208652274" "False" "High" "IsMasterProtein" "O96028" "Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1" "0.008" "False" "2.283" "1" "1" "1" "1" "1365" "152.2" "8.69" "2.87" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf00628, Pf00855, Pf00856, Pf17907, Pf17982" "7468" "ENSG00000109685" "NSD2" "A2A2T2; A2A2T3; A2A2T4; A7MCZ1; D3DVQ2; hsa:7468; O96028; O96031; Q4VBY8; Q672J1; Q6IS00; Q86V01; Q9BZB4; Q9UI92; Q9UPR2" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "4p16.3 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8918324511185795548" "False" "High" "IsMasterProtein" "Q9BVC4" "Target of rapamycin complex subunit LST8 OS=Homo sapiens OX=9606 GN=MLST8 PE=1 SV=1" "0.008" "False" "2.277" "4" "1" "1" "1" "326" "35.9" "5.86" "2.39" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00400" "64223" "ENSG00000167965" "MLST8" "B3KMM4; B4DY00; D3DU88; hsa:64223; Q5M800; Q86Y18; Q8WUI5; Q9BVC4; Q9HA66; Q9UJV6" "Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "34" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6391839617332390225" "False" "High" "IsMasterProtein" "P07203" "Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4" "0.008" "False" "2.276" "5" "1" "1" "1" "203" "22.1" "6.55" "2.37" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00255" "2876" "ENSG00000233276" "GPX1" "E9PAS1; hsa:2876; P07203; Q7Z5H1; Q9BW12" "Detoxification of Reactive Oxygen Species; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; One-carbon metabolism and related pathways; TYROBP causal network in microglia; Oxidative stress response; Male infertility; p53 transcriptional gene network; Omega-6-fatty acids in senescence" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9029102055172413672" "False" "High" "IsMasterProtein" "Q8TEL6" "Short transient receptor potential channel 4-associated protein OS=Homo sapiens OX=9606 GN=TRPC4AP PE=1 SV=2" "0.009" "False" "2.258" "2" "1" "1" "1" "797" "90.8" "7.61" "2.60" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf12463" "26133" "ENSG00000100991" "TRPC4AP" "E1P5Q0; E1P5Q1; hsa:26133; Q8TEL6; Q96H82; Q9BVB8; Q9H429; Q9UFS6" "TRP channels" "IL-18 signaling pathway" "2" "0" "0.879" "1.015" "1.195" "1.035" "0.878" "0.933" "1.009" "1.003" "1.169" "37.3" "32.8" "37.9" "44.6" "38.6" "32.8" "34.8" "37.7" "37.4" "43.6" "" "" "" "" "" "" "" "" "" "" "30.0" "23.7" "30.1" "29.9" "26.7" "24.6" "24.4" "27.5" "37.4" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1196962493120422710" "False" "High" "IsMasterProtein" "Q9BSF8" "BTB/POZ domain-containing protein 10 OS=Homo sapiens OX=9606 GN=BTBD10 PE=1 SV=2" "0.009" "False" "2.254" "1" "1" "1" "1" "475" "53.7" "7.77" "3.12" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf16017" "84280" "ENSG00000148925" "BTBD10" "B7Z228; hsa:84280; Q86WG1; Q9BSF8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2459990340720831068" "False" "High" "IsMasterProtein" "Q8N1G1" "RNA exonuclease 1 homolog OS=Homo sapiens OX=9606 GN=REXO1 PE=1 SV=3" "0.009" "False" "2.249" "1" "1" "1" "1" "1221" "131.4" "8.95" "1.95" "1" "" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15870" "57455" "ENSG00000079313" "REXO1" "hsa:57455; Q8N1G1; Q9ULT2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1879348305220044613" "False" "High" "IsMasterProtein" "P22732" "Solute carrier family 2, facilitated glucose transporter member 5 OS=Homo sapiens OX=9606 GN=SLC2A5 PE=1 SV=1" "0.009" "False" "2.245" "1" "1" "1" "1" "501" "54.9" "6.04" "2.93" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00083" "6518" "ENSG00000142583" "SLC2A5" "hsa:6518; P22732; Q14770; Q5T977; Q8IVB3" "Neutrophil degranulation; Intestinal hexose absorption" "Nuclear receptors meta-pathway; NRF2 pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3701102835141245935" "False" "High" "IsMasterProtein" "Q9HBH9" "MAP kinase-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=MKNK2 PE=1 SV=3" "0.009" "False" "2.240" "3" "1" "1" "1" "465" "51.8" "6.19" "2.99" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "2872" "ENSG00000099875" "MKNK2" "hsa:2872; Q6GPI3; Q9HBH8; Q9HBH9; Q9UHR0; Q9Y2N6" "" "Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Pleural mesothelioma" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1359330944425919682" "False" "High" "IsMasterProtein" "Q53T94" "TATA box-binding protein-associated factor RNA polymerase I subunit B OS=Homo sapiens OX=9606 GN=TAF1B PE=1 SV=1" "0.009" "False" "2.236" "2" "1" "1" "1" "588" "68.8" "8.02" "2.26" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11781, Pf20644, Pf20645" "9014" "ENSG00000115750" "TAF1B" "B4DI42; F8WD72; hsa:9014; Q15574; Q53T94; Q8WVC3" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; SIRT1 negatively regulates rRNA expression" "Rett syndrome" "7" "0" "1.113" "1.151" "1.162" "1.033" "1.317" "0.821" "0.959" "1.014" "0.805" "36.4" "40.5" "41.9" "42.3" "37.6" "47.9" "29.9" "34.9" "36.9" "29.3" "" "" "" "" "" "" "" "" "" "" "29.2" "29.2" "33.3" "28.3" "26.0" "36.0" "20.9" "25.5" "36.9" "23.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013178931392780313" "False" "High" "IsMasterProtein" "Q9H6V9" "Lipid droplet-associated hydrolase OS=Homo sapiens OX=9606 GN=LDAH PE=1 SV=1" "0.009" "False" "2.235" "3" "1" "1" "1" "325" "37.3" "6.54" "1.88" "1" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf10230" "60526" "ENSG00000118961" "LDAH" "B7ZA47; B7ZAJ5; D6W530; E7ESN0; hsa:60526; Q53T37; Q53T58; Q9H6V9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1455362657326634232" "False" "High" "IsMasterProtein" "Q02543" "Large ribosomal subunit protein eL20 OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2" "0.009" "False" "2.227" "6" "1" "1" "1" "176" "20.7" "10.71" "2.86" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01775" "6142" "ENSG00000105640" "RPL18A" "hsa:6142; Q02543" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5665965476907478447" "False" "High" "IsMasterProtein" "P58557" "Endoribonuclease YbeY OS=Homo sapiens OX=9606 GN=YBEY PE=1 SV=2" "0.009" "False" "2.226" "5" "1" "1" "1" "167" "19.3" "7.55" "2.25" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf02130" "54059" "ENSG00000182362" "YBEY" "B7WPA9; B7WPF7; D3DSN2; hsa:54059; P58557" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1292459384444475416" "False" "High" "IsMasterProtein" "Q8N111" "Cell cycle exit and neuronal differentiation protein 1 OS=Homo sapiens OX=9606 GN=CEND1 PE=1 SV=1" "0.009" "False" "2.226" "6" "1" "2" "1" "149" "14.9" "9.20" "5.05" "1" "developmental processes;other biological processes" "other membranes" "" "Pf15677" "51286" "ENSG00000184524" "CEND1" "hsa:51286; Q8N111; Q9NYM6" "" "" "0" "0" "0.881" "0.824" "0.841" "0.742" "0.868" "0.991" "0.928" "0.836" "0.867" "78.3" "69.0" "64.6" "65.9" "58.1" "68.0" "77.6" "72.7" "65.5" "67.9" "" "" "" "" "" "" "" "" "" "" "62.9" "49.8" "51.3" "44.2" "40.2" "51.0" "54.3" "53.1" "65.5" "55.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686055007853135805" "False" "High" "IsMasterProtein" "A6QL64" "Ankyrin repeat domain-containing protein 36A OS=Homo sapiens OX=9606 GN=ANKRD36 PE=1 SV=4" "0.009" "False" "2.226" "3" "1" "1" "1" "1915" "214.4" "8.70" "2.31" "1" "" "" "" "Pf12796, Pf14915" "375248" "ENSG00000135976; ENSG00000291582" "ANKRD36" "A0A494C0M0; A6QL64; B4E3I8; Q6UX02; Q86X62; Q9HCD1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037258603534985886" "False" "High" "IsMasterProtein" "Q12974" "Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1" "0.009" "False" "2.222" "4" "1" "1" "1" "167" "19.1" "8.37" "3.43" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102" "8073" "ENSG00000184007" "PTP4A2" "A8K9I8; B4DM39; D3DPP0; E9PGJ6; hsa:8073; O00649; Q12974; Q15197; Q15259; Q15260; Q15261; R4GN50" "RAB geranylgeranylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1750728532915828857" "False" "High" "IsMasterProtein" "P26010" "Integrin beta-7 OS=Homo sapiens OX=9606 GN=ITGB7 PE=1 SV=1" "0.009" "False" "2.220" "1" "1" "1" "1" "798" "86.8" "6.04" "2.91" "1" "cell adhesion;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00362, Pf07974, Pf08725, Pf17205" "3695" "ENSG00000139626" "ITGB7" "hsa:3695; P26010; Q9UCP7; Q9UCS7" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions" "Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms" "8" "0" "1.063" "1.017" "0.972" "1.166" "1.087" "1.148" "1.028" "1.199" "1.090" "83.0" "88.1" "84.4" "80.7" "96.7" "90.2" "95.2" "85.2" "99.4" "90.4" "" "" "" "" "" "" "" "" "" "" "66.6" "63.6" "67.0" "54.0" "66.9" "67.6" "66.7" "62.3" "99.4" "73.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3073317532419455068" "False" "High" "IsMasterProtein" "Q07954" "Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2" "0.010" "False" "2.217" "0" "1" "1" "1" "4544" "504.3" "5.39" "2.45" "1" "other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00057, Pf00058, Pf07645, Pf12662, Pf14670, Pf16472" "4035" "ENSG00000123384" "LRP1" "hsa:4035; Q07954; Q2PP12; Q86SW0; Q8IVG8" "Scavenging of heme from plasma; Retinoid metabolism and transport" "Alzheimer's disease and miRNA effects; Regulation of Wnt / B-catenin signaling by small molecule compounds; Statin inhibition of cholesterol production; Familial hyperlipidemia type 1; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Cholesterol metabolism" "11" "0" "1.082" "1.162" "1.146" "1.293" "1.041" "1.173" "1.238" "1.157" "1.243" "160.7" "173.9" "186.8" "184.1" "207.8" "167.4" "188.6" "198.9" "185.9" "199.8" "" "" "" "" "" "" "" "" "" "" "129.1" "125.5" "148.4" "123.4" "143.7" "125.6" "132.0" "145.3" "185.9" "162.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4320196251115137643" "False" "High" "IsMasterProtein" "O43405" "Cochlin OS=Homo sapiens OX=9606 GN=COCH PE=1 SV=1" "0.010" "False" "2.217" "1" "1" "1" "1" "550" "59.4" "7.96" "3.37" "1" "other biological processes" "non-structural extracellular;extracellular matrix" "other molecular function" "Pf00092, Pf03815" "1690" "ENSG00000100473" "COCH" "A8K9K9; D3DS84; hsa:1690; O43405; Q96IU6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2133311852660354058" "False" "High" "IsMasterProtein" "P49795" "Regulator of G-protein signaling 19 OS=Homo sapiens OX=9606 GN=RGS19 PE=1 SV=1" "0.010" "False" "2.211" "6" "1" "1" "1" "217" "24.6" "5.62" "1.85" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00615" "10287" "ENSG00000171700" "RGS19" "A8K216; E1P5G9; hsa:10287; P49795; Q53XN0; Q8TD60" "G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "5" "0" "0.982" "0.972" "1.144" "1.019" "1.185" "1.315" "1.067" "0.957" "1.094" "25.3" "24.9" "24.6" "29.0" "25.8" "30.0" "33.3" "27.0" "24.2" "27.7" "" "" "" "" "" "" "" "" "" "" "20.3" "18.0" "19.6" "19.4" "17.9" "22.5" "23.3" "19.7" "24.2" "22.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354971542348250461" "False" "High" "IsMasterProtein" "Q96BW9" "Phosphatidate cytidylyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TAMM41 PE=1 SV=2" "0.010" "False" "2.210" "2" "1" "1" "1" "452" "51.0" "7.94" "2.49" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf09139" "132001" "ENSG00000144559" "TAMM41" "B4DIY7; C9J2U4; hsa:132001; Q96BW9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "75736922320642282" "False" "High" "IsMasterProtein" "O95568" "Histidine protein methyltransferase 1 homolog OS=Homo sapiens OX=9606 GN=METTL18 PE=1 SV=1" "0.010" "False" "2.195" "2" "1" "1" "1" "372" "42.1" "6.76" "3.02" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13489" "92342" "ENSG00000171806" "METTL18" "B2R9T5; hsa:92342; O95568" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181801566147429502" "False" "High" "IsMasterProtein" "Q9UHV7" "Mediator of RNA polymerase II transcription subunit 13 OS=Homo sapiens OX=9606 GN=MED13 PE=1 SV=3" "0.010" "False" "2.194" "1" "1" "1" "1" "2174" "239.1" "5.64" "1.91" "1" "other biological processes" "nucleus" "other molecular function" "Pf06333, Pf18296" "9969" "ENSG00000108510" "MED13" "B2RU05; hsa:9969; O60334; Q9UHV7" "Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "" "4" "0" "1.149" "1.040" "0.744" "0.878" "1.063" "1.204" "0.892" "1.101" "0.896" "23.5" "27.0" "24.4" "17.5" "20.6" "25.0" "28.3" "21.0" "25.9" "21.0" "" "" "" "" "" "" "" "" "" "" "18.9" "19.5" "19.4" "11.7" "14.3" "18.7" "19.8" "15.3" "25.9" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2422870535062940467" "False" "Medium" "IsMasterProtein" "Q9P0J0" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Homo sapiens OX=9606 GN=NDUFA13 PE=1 SV=3" "0.010" "False" "2.191" "9" "1" "1" "1" "144" "16.7" "8.43" "1.91" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf06212" "51079" "ENSG00000186010" "NDUFA13" "B4DF76; hsa:51079; K7EK58; Q6PKI0; Q9H2L3; Q9P0J0; Q9Y327" "Mitochondrial protein degradation; Complex I biogenesis" "Nucleotide-binding oligomerization domain (NOD) pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease" "6" "0" "1.309" "1.030" "1.613" "1.287" "1.213" "1.287" "1.123" "1.200" "1.228" "20.9" "27.4" "21.5" "33.7" "26.9" "25.4" "26.9" "23.5" "25.1" "25.7" "" "" "" "" "" "" "" "" "" "" "16.8" "19.7" "17.1" "22.6" "18.6" "19.0" "18.8" "17.1" "25.1" "20.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6312781916625640811" "False" "Medium" "IsMasterProtein" "Q96AP4" "Zinc finger-containing ubiquitin peptidase 1 OS=Homo sapiens OX=9606 GN=ZUP1 PE=1 SV=1" "0.010" "False" "2.188" "2" "1" "2" "1" "578" "65.9" "6.49" "0.00" "1" "" "cytosol;nucleus" "other molecular function" "Pf07910" "221302" "ENSG00000153975" "ZUP1" "hsa:221302; Q5TD92; Q6PJH7; Q96AP4; Q96NV6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2678984793925547724" "False" "Medium" "IsMasterProtein" "Q8NCJ5" "SPRY domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SPRYD3 PE=1 SV=2" "0.011" "False" "2.185" "2" "1" "1" "1" "442" "49.7" "6.16" "2.70" "1" "" "" "" "Pf00622" "84926" "ENSG00000167778" "SPRYD3" "B9EG99; hsa:84926; Q8NCJ5; Q96SK5" "" "" "0" "0" "0.939" "1.157" "1.074" "0.926" "1.188" "1.035" "1.063" "1.070" "0.984" "49.7" "46.7" "57.6" "53.4" "46.1" "59.1" "51.5" "52.9" "53.2" "49.0" "" "" "" "" "" "" "" "" "" "" "40.0" "33.7" "45.7" "35.8" "31.9" "44.3" "36.0" "38.6" "53.2" "39.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7823550792451491475" "False" "Medium" "IsMasterProtein" "Q14CS0" "UBX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=UBXN2B PE=1 SV=1" "0.011" "False" "2.184" "3" "1" "1" "1" "331" "37.1" "5.64" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf08059" "137886" "ENSG00000215114" "UBXN2B" "B3KWZ3; hsa:137886; Q14CS0" "" "" "0" "0" "0.923" "1.099" "1.094" "1.195" "1.094" "1.008" "1.170" "0.990" "0.801" "16.8" "15.5" "18.5" "18.4" "20.1" "18.4" "16.9" "19.7" "16.6" "13.5" "" "" "" "" "" "" "" "" "" "" "13.5" "11.2" "14.7" "12.3" "13.9" "13.8" "11.9" "14.4" "16.6" "10.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6544451976657015387" "False" "Medium" "IsMasterProtein" "Q8TC44" "POC1 centriolar protein homolog B OS=Homo sapiens OX=9606 GN=POC1B PE=1 SV=1" "0.011" "False" "2.180" "1" "1" "1" "1" "478" "53.6" "7.24" "2.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "282809" "ENSG00000139323" "POC1B" "G3V1X0; hsa:282809; Q8TC44" "" "Ciliopathies" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4512542596092401927" "False" "Medium" "IsMasterProtein" "Q15390" "Mitochondrial fission regulator 1 OS=Homo sapiens OX=9606 GN=MTFR1 PE=1 SV=2" "0.011" "False" "2.177" "3" "1" "1" "1" "333" "37.0" "9.01" "2.38" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf05308" "9650" "ENSG00000066855" "MTFR1" "E7EP84; hsa:9650; Q15390; Q6IB94; Q7Z669; Q86XH5; Q8IVD7" "" "" "0" "0" "0.806" "0.822" "0.900" "0.736" "0.859" "0.943" "0.768" "0.992" "0.911" "39.5" "31.8" "32.5" "35.5" "29.1" "33.9" "37.2" "30.3" "39.1" "36.0" "" "" "" "" "" "" "" "" "" "" "31.7" "23.0" "25.8" "23.8" "20.1" "25.4" "26.1" "22.1" "39.1" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1970257073034718295" "False" "Medium" "IsMasterProtein" "Q6RW13" "Type-1 angiotensin II receptor-associated protein OS=Homo sapiens OX=9606 GN=AGTRAP PE=1 SV=1" "0.011" "False" "2.176" "14" "1" "1" "1" "159" "17.4" "6.14" "2.59" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf06396" "57085" "ENSG00000177674" "AGTRAP" "A8MVQ5; hsa:57085; Q5SNV4; Q5SNV5; Q6RW13; Q96AC0; Q96PL4; Q9NRW9" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7298317217848913282" "False" "Medium" "IsMasterProtein" "O75382" "Tripartite motif-containing protein 3 OS=Homo sapiens OX=9606 GN=TRIM3 PE=1 SV=2" "0.011" "False" "2.168" "1" "1" "1" "1" "744" "80.8" "7.83" "2.76" "1" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00097, Pf00630, Pf00643, Pf01436" "10612" "ENSG00000110171" "TRIM3" "B7Z5E6; F5H2Q8; hsa:10612; O75382; Q4V9L4; Q9C038; Q9C039" "Interferon gamma signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-181287195693513573" "False" "Medium" "IsMasterProtein" "Q96EA4" "Protein Spindly OS=Homo sapiens OX=9606 GN=SPDL1 PE=1 SV=2" "0.011" "False" "2.167" "2" "1" "1" "1" "605" "70.1" "5.47" "2.45" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "54908" "ENSG00000040275" "SPDL1" "B4E393; C9JS47; hsa:54908; Q8TEC8; Q96EA4; Q9HD44; Q9NX97" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-965135399172773459" "False" "Medium" "IsMasterProtein" "Q00978" "Interferon regulatory factor 9 OS=Homo sapiens OX=9606 GN=IRF9 PE=1 SV=1" "0.011" "False" "2.165" "2" "1" "1" "1" "393" "43.7" "5.77" "2.18" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "10379" "ENSG00000213928; ENSG00000285048" "IRF9" "D3DS61; hsa:10379; Q00978" "Interferon gamma signaling; Interferon alpha/beta signaling" "Type III interferon signaling; Immune response to tuberculosis; Overview of interferons-mediated signaling pathway; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; p53 transcriptional gene network; Interferon type I signaling pathways; Type II interferon signaling" "12" "0" "0.994" "1.013" "1.131" "1.156" "0.996" "1.131" "1.057" "1.104" "1.244" "220.5" "219.2" "223.3" "249.4" "254.9" "219.6" "249.3" "233.0" "243.4" "274.2" "" "" "" "" "" "" "" "" "" "" "177.1" "158.2" "177.4" "167.1" "176.3" "164.7" "174.5" "170.2" "243.4" "223.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "461766419271879158" "False" "Medium" "IsMasterProtein" "Q96BR1" "Serine/threonine-protein kinase Sgk3 OS=Homo sapiens OX=9606 GN=SGK3 PE=1 SV=1" "0.011" "False" "2.153" "1" "1" "1" "1" "496" "57.1" "6.93" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf00787" "100533105; 23678" "ENSG00000104205" "SGK3" "A8K5W3; B3KQC2; hsa:100533105; hsa:23678; Q96BR1; Q9P1Q7; Q9UKG5" "Stimuli-sensing channels" "PI3K-Akt signaling pathway; Insulin signaling; HDAC6 interactions in the central nervous system" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2992293195289622245" "False" "Medium" "IsMasterProtein" "Q15005" "Signal peptidase complex subunit 2 OS=Homo sapiens OX=9606 GN=SPCS2 PE=1 SV=3" "0.011" "False" "2.149" "10" "1" "1" "1" "226" "25.0" "8.47" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "" "Pf06703" "9789" "ENSG00000118363" "SPCS2" "hsa:9789; Q15005; Q15507; Q3KQT0; Q641R4; Q6FG65; Q6IRX0; Q6P1P4; Q96HU9" "SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Maturation of hRSV A proteins; Synthesis, secretion, and deacylation of Ghrelin" "15q25 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-2977729941869003476" "False" "Medium" "IsMasterProtein" "Q6P4F7" "Rho GTPase-activating protein 11A OS=Homo sapiens OX=9606 GN=ARHGAP11A PE=1 SV=2" "0.012" "False" "2.141" "1" "1" "1" "1" "1023" "113.8" "9.07" "1.87" "1" "signal transduction;other biological processes" "cytosol;nucleus" "enzyme regulator activity" "Pf00620" "9824" "ENSG00000198826; ENSG00000275568" "ARHGAP11A" "B4DZN9; hsa:9824; Q6P4F7; Q6PI96; Q9Y3S6" "RHOA GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2150504765694079773" "False" "Medium" "IsMasterProtein" "Q4ADV7" "Guanine nucleotide exchange factor subunit RIC1 OS=Homo sapiens OX=9606 GN=RIC1 PE=1 SV=2" "0.012" "False" "2.138" "1" "1" "1" "1" "1423" "159.2" "6.38" "2.35" "1" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf07064" "57589" "ENSG00000107036" "RIC1" "B2RN24; B7ZM67; G5E932; hsa:57589; Q4ADV7; Q4VXJ8; Q4VXJ9; Q76MT5; Q8N6E0; Q8TEH4; Q9H0A5; Q9H9S1" "RAB GEFs exchange GTP for GDP on RABs; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1999315358904826558" "False" "Medium" "IsMasterProtein" "P01040" "Cystatin-A OS=Homo sapiens OX=9606 GN=CSTA PE=1 SV=1" "0.012" "False" "2.137" "7" "1" "1" "1" "98" "11.0" "5.50" "2.32" "1" "cell adhesion;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1475" "ENSG00000121552" "CSTA" "hsa:1475; P01040; Q6IB90" "Formation of the cornified envelope" "8p23.1 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7567103960318727217" "False" "Medium" "IsMasterProtein" "Q08999" "Retinoblastoma-like protein 2 OS=Homo sapiens OX=9606 GN=RBL2 PE=1 SV=3" "0.012" "False" "2.127" "1" "1" "1" "1" "1139" "128.3" "7.44" "2.57" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf11934" "5934" "ENSG00000103479" "RBL2" "B7Z913; hsa:5934; Q08999; Q15073; Q16084; Q8NE70; Q92812" "Cyclin D associated events in G1; FOXO-mediated transcription of cell cycle genes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Adipogenesis; TGF-beta signaling pathway; PI3K-Akt signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; ID signaling pathway; DNA damage response (only ATM dependent); Monoamine transport" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3192969394575095847" "False" "Medium" "IsMasterProtein" "Q9BT17" "Mitochondrial ribosome-associated GTPase 1 OS=Homo sapiens OX=9606 GN=MTG1 PE=1 SV=2" "0.012" "False" "2.124" "3" "1" "1" "1" "334" "37.2" "9.47" "3.01" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01926" "92170" "ENSG00000148824" "MTG1" "hsa:92170; Q5VWX8; Q6PIY9; Q8IYJ4; Q8NC48; Q9BT17; Q9BVU8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595172550313309815" "False" "Medium" "IsMasterProtein" "Q9BY41" "Histone deacetylase 8 OS=Homo sapiens OX=9606 GN=HDAC8 PE=1 SV=2" "0.012" "False" "2.121" "5" "1" "1" "1" "377" "41.7" "5.63" "2.06" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "55869" "ENSG00000147099" "HDAC8" "A6ND12; A6ND61; A6NET3; A6NJR3; A8MQ62; B4DKN0; B4DV22; hsa:55869; Q86VC8; Q9BY41; Q9NP76; Q9NYH4" "HDACs deacetylate histones; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Rett syndrome; Cohesin complex - Cornelia de Lange syndrome" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1276510968387632790" "False" "Medium" "IsMasterProtein" "P22794" "Protein EVI2A OS=Homo sapiens OX=9606 GN=EVI2A PE=1 SV=2" "0.012" "False" "2.121" "3" "1" "1" "1" "236" "26.2" "8.56" "2.64" "1" "" "other membranes" "other molecular function" "Pf05399" "2123" "ENSG00000126860" "EVI2A" "B2R5X2; B4DHX8; hsa:2123; P22794" "" "NF1 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8914227060072634545" "False" "Medium" "IsMasterProtein" "O96009" "Napsin-A OS=Homo sapiens OX=9606 GN=NAPSA PE=1 SV=1" "0.013" "False" "2.111" "2" "1" "1" "1" "420" "45.4" "6.61" "2.88" "1" "protein metabolism;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026" "9476" "ENSG00000131400" "NAPSA" "hsa:9476; O96009; Q8WWD9" "Surfactant metabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5739476277028955358" "False" "Medium" "IsMasterProtein" "Q86TJ2" "Transcriptional adapter 2-beta OS=Homo sapiens OX=9606 GN=TADA2B PE=1 SV=2" "0.014" "False" "2.100" "2" "1" "1" "1" "420" "48.4" "7.83" "3.15" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249" "93624" "ENSG00000173011" "TADA2B" "A0AUJ8; A4QMR7; B3KSN0; B3KU86; hsa:93624; Q6MZG9; Q86TJ2" "Ub-specific processing proteases; HATs acetylate histones" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1504657578828453031" "False" "Medium" "IsMasterProtein" "P98198" "Phospholipid-transporting ATPase ID OS=Homo sapiens OX=9606 GN=ATP8B2 PE=1 SV=2" "0.014" "False" "2.089" "1" "1" "1" "1" "1209" "137.4" "7.01" "0.00" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf13246, Pf16209, Pf16212" "57198" "ENSG00000143515" "ATP8B2" "B4E3P4; hsa:57198; P98198; Q6NT69; Q7Z486; Q96I43; Q96NQ7" "Ion transport by P-type ATPases" "Mesodermal commitment pathway; Complement system in neuronal development and plasticity" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9000189900637042825" "False" "Medium" "IsMasterProtein" "Q6JQN1" "Acyl-CoA dehydrogenase family member 10 OS=Homo sapiens OX=9606 GN=ACAD10 PE=1 SV=1" "0.014" "False" "2.082" "1" "1" "1" "1" "1059" "118.8" "8.06" "2.34" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00441, Pf00702, Pf01636, Pf02770, Pf02771" "80724" "ENSG00000111271" "ACAD10" "G3XAJ0; hsa:80724; Q6JQN1; Q8N828; Q8NAP2; Q96BX5" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "1.077" "1.149" "1.067" "1.230" "1.068" "0.941" "1.096" "1.075" "1.106" "65.1" "70.1" "74.8" "69.4" "80.1" "69.5" "61.2" "71.3" "70.0" "72.0" "" "" "" "" "" "" "" "" "" "" "52.3" "50.6" "59.4" "46.5" "55.4" "52.1" "42.9" "52.1" "70.0" "58.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8632982163775733346" "False" "Medium" "IsMasterProtein" "A6NK58" "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial OS=Homo sapiens OX=9606 GN=LIPT2 PE=1 SV=1" "0.014" "False" "2.080" "4" "1" "1" "1" "231" "25.2" "8.27" "1.83" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "" "387787" "ENSG00000175536" "LIPT2" "A6NK58; hsa:387787" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "1.596" "1.170" "1.146" "0.915" "1.379" "1.303" "1.248" "1.246" "1.774" "21.2" "33.8" "24.8" "24.3" "19.4" "29.2" "27.6" "26.4" "26.4" "37.6" "" "" "" "" "" "" "" "" "" "" "17.0" "24.4" "19.7" "16.3" "13.4" "21.9" "19.3" "19.3" "26.4" "30.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1043933861816378704" "False" "Medium" "IsMasterProtein" "O60303" "Katanin-interacting protein OS=Homo sapiens OX=9606 GN=KATNIP PE=1 SV=4" "0.014" "False" "2.078" "1" "1" "1" "1" "1618" "180.8" "5.87" "0.00" "1" "transport" "cytoskeleton;other cell component" "" "Pf14652" "23247" "ENSG00000047578" "KATNIP" "A7E2C2; hsa:23247; O60303" "" "Ciliopathies" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "1" "" "1730131359197889533" "False" "Medium" "IsMasterProtein" "Q8IVU3" "Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2" "0.013" "False" "2.076" "1" "1" "1" "1" "1022" "115.1" "7.96" "2.76" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632, Pf13540" "55008" "ENSG00000138642" "HERC6" "B4DIY5; hsa:55008; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8IVU3; Q8NAN3; Q9NWS4" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8091364361114664621" "False" "Medium" "IsMasterProtein" "Q5VYV7" "Protein SLX4IP OS=Homo sapiens OX=9606 GN=SLX4IP PE=1 SV=1" "0.014" "False" "2.071" "3" "1" "1" "1" "408" "45.5" "9.42" "2.67" "1" "" "" "" "Pf15744" "128710" "ENSG00000149346" "SLX4IP" "hsa:128710; Q05CG2; Q05CT9; Q5VYV7" "" "Nucleotide excision repair in xeroderma pigmentosum" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023835603968378243" "False" "Medium" "IsMasterProtein" "O75506" "Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1" "0.014" "False" "2.071" "14" "1" "2" "1" "76" "8.5" "4.36" "4.64" "1" "stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06825" "3281" "ENSG00000230989" "HSBP1" "hsa:3281; O75506; Q53XA8; Q7Z5Z3" "HSF1 activation; Attenuation phase" "" "3" "0" "1.109" "1.136" "1.034" "0.896" "0.967" "0.904" "0.858" "1.080" "0.970" "159.9" "177.4" "181.6" "165.3" "143.4" "154.7" "144.5" "137.2" "172.7" "155.1" "" "" "" "" "" "" "" "" "" "" "128.5" "128.0" "144.3" "110.8" "99.1" "116.0" "101.2" "100.2" "172.7" "126.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8970709924298765411" "False" "Medium" "IsMasterProtein" "Q9HCI7" "E3 ubiquitin-protein ligase MSL2 OS=Homo sapiens OX=9606 GN=MSL2 PE=1 SV=2" "0.014" "False" "2.062" "2" "1" "1" "1" "577" "62.5" "7.80" "2.98" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf16682, Pf16685" "55167" "ENSG00000174579" "MSL2" "B4DYL4; G5E9I1; hsa:55167; Q0D2P1; Q8NDB4; Q9HCI7; Q9NVS4" "HATs acetylate histones" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100464243051471028" "False" "Medium" "IsMasterProtein" "Q9H063" "Repressor of RNA polymerase III transcription MAF1 homolog OS=Homo sapiens OX=9606 GN=MAF1 PE=1 SV=2" "0.014" "False" "2.058" "5" "1" "1" "1" "256" "28.8" "4.55" "2.16" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09174" "84232" "ENSG00000179632" "MAF1" "D3DWL4; hsa:84232; Q9H063" "Regulation of PTEN gene transcription" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65885547714639477" "False" "Medium" "IsMasterProtein" "O60308" "Centrosomal protein of 104 kDa OS=Homo sapiens OX=9606 GN=CEP104 PE=1 SV=1" "0.014" "False" "2.053" "1" "1" "1" "1" "925" "104.4" "7.62" "2.79" "1" "" "cytoskeleton;other cell component" "" "Pf21038, Pf21039" "9731" "ENSG00000116198" "CEP104" "A0A024R4G3; hsa:9731; O60308; Q5JSQ3; Q5SR24; Q5SR25; Q6PKF5; Q86W32; Q86X14" "" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9045329245485250049" "False" "Medium" "IsMasterProtein" "Q9BW66" "Cyclin-dependent kinase 2-interacting protein OS=Homo sapiens OX=9606 GN=CINP PE=1 SV=1" "0.014" "False" "2.039" "4" "1" "1" "1" "212" "24.3" "6.28" "2.75" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "" "51550" "ENSG00000100865" "CINP" "F5H7P3; F5H8A7; hsa:51550; Q9BW66; Q9NPF9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "403874813185582300" "False" "Medium" "IsMasterProtein" "P36897" "TGF-beta receptor type-1 OS=Homo sapiens OX=9606 GN=TGFBR1 PE=1 SV=1" "0.014" "False" "2.034" "3" "1" "2" "1" "503" "55.9" "7.55" "2.04" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf01064, Pf08515" "7046" "ENSG00000106799" "TGFBR1" "hsa:7046; P36897; Q6IR47; Q706C0; Q706C1" "UCH proteinases; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer" "Cardiac hypertrophic response; Extracellular vesicle-mediated signaling in recipient cells; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; TYROBP causal network in microglia; p38 MAPK signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; LDLRAD4 and what we know about it; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; GDNF signaling; TGF-beta receptor signaling" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5891546535660205639" "False" "Medium" "IsMasterProtein" "Q6P1X6" "UPF0598 protein C8orf82 OS=Homo sapiens OX=9606 GN=C8orf82 PE=1 SV=2" "0.015" "False" "2.033" "4" "1" "1" "1" "216" "23.9" "9.14" "2.65" "1" "" "" "" "Pf14956" "414919" "ENSG00000213563" "C8orf82" "hsa:414919; Q6GMR2; Q6P1X6; Q6P2Q7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802052166726839277" "False" "Medium" "IsMasterProtein" "O75884" "Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2" "0.015" "False" "2.031" "4" "1" "1" "1" "186" "21.0" "6.20" "2.30" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf06821" "10741" "ENSG00000089050" "RBBP9" "D3DW31; hsa:10741; O75884; Q5JPH9; Q9H1D8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6661052113090988194" "False" "Medium" "IsMasterProtein" "O95153" "Peripheral-type benzodiazepine receptor-associated protein 1 OS=Homo sapiens OX=9606 GN=TSPOAP1 PE=1 SV=2" "0.015" "False" "2.029" "1" "1" "3" "1" "1857" "199.9" "5.11" "0.00" "1" "transport" "cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity" "Pf07653, Pf14604" "9256" "ENSG00000005379" "TSPOAP1" "hsa:9256; O75111; O95153; Q8N5W3" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Pregnenolone biosynthesis" "" "6" "0" "1.183" "1.317" "1.095" "1.296" "1.002" "1.143" "1.352" "1.268" "1.308" "88.1" "104.2" "116.0" "96.4" "114.2" "88.3" "100.7" "119.1" "111.8" "115.2" "" "" "" "" "" "" "" "" "" "" "70.8" "75.2" "92.1" "64.6" "79.0" "66.2" "70.5" "87.0" "111.8" "93.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4123953138095996018" "False" "Medium" "IsMasterProtein" "O95398" "Rap guanine nucleotide exchange factor 3 OS=Homo sapiens OX=9606 GN=RAPGEF3 PE=1 SV=6" "0.015" "False" "2.026" "1" "1" "1" "1" "923" "103.7" "7.56" "2.64" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf00610, Pf00617, Pf00618" "10411" "ENSG00000079337" "RAPGEF3" "A8K2G5; E7EQC8; hsa:10411; O95398; O95634; Q8WVN0" "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Integrin signaling; Rap1 signalling" "Corticotropin-releasing hormone signaling pathway; EPAC1 and PKA reduction of retinal inflammation" "6" "0" "1.055" "1.156" "1.265" "1.743" "1.074" "1.448" "1.309" "1.131" "1.264" "86.5" "91.3" "100.0" "109.4" "150.8" "92.9" "125.3" "113.2" "97.8" "109.4" "" "" "" "" "" "" "" "" "" "" "69.5" "65.9" "79.4" "73.3" "104.3" "69.7" "87.7" "82.7" "97.8" "88.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5300611953044969662" "False" "Medium" "IsMasterProtein" "Q9BSJ5" "Mitochondrial nucleoid-associated protein 1 OS=Homo sapiens OX=9606 GN=MTNAP1 PE=1 SV=2" "0.015" "False" "2.020" "2" "1" "1" "1" "609" "67.3" "9.16" "2.68" "1" "" "other membranes" "" "" "55028" "ENSG00000141219" "C17orf80" "A8K9X3; Q5JB45; Q6YAU3; Q9BSJ5; Q9H0L9; Q9H5E6; Q9NWN5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5312560653861073020" "False" "Medium" "IsMasterProtein" "P82932" "Small ribosomal subunit protein bS6m OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3" "0.015" "False" "2.014" "10" "1" "1" "1" "125" "14.2" "9.26" "2.96" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01250" "64968" "ENSG00000243927" "MRPS6" "B2R573; hsa:64968; P82932; Q96Q64; Q9BSK8; Q9BW89" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.944" "0.892" "0.947" "0.831" "0.928" "0.928" "1.002" "0.855" "0.889" "292.8" "276.3" "261.3" "277.2" "243.4" "271.7" "271.7" "293.4" "250.4" "260.2" "" "" "" "" "" "" "" "" "" "" "235.2" "199.3" "207.5" "185.7" "168.3" "203.9" "190.2" "214.3" "250.4" "211.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3570886289104636423" "False" "Medium" "IsMasterProtein" "Q9NYP9" "Protein Mis18-alpha OS=Homo sapiens OX=9606 GN=MIS18A PE=1 SV=1" "0.015" "False" "2.012" "5" "1" "1" "1" "233" "25.8" "5.20" "2.51" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03226" "54069" "ENSG00000159055" "MIS18A" "B2R562; hsa:54069; Q542Z0; Q9NYP9" "Deposition of new CENPA-containing nucleosomes at the centromere" "" "1" "0" "0.746" "0.888" "0.603" "0.668" "1.125" "0.724" "0.709" "0.962" "0.708" "50.8" "37.9" "45.2" "30.6" "33.9" "57.2" "36.8" "36.0" "48.9" "36.0" "" "" "" "" "" "" "" "" "" "" "40.8" "27.4" "35.9" "20.5" "23.5" "42.9" "25.8" "26.3" "48.9" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1960007696213453996" "False" "Medium" "IsMasterProtein" "Q8NE01" "Metal transporter CNNM3 OS=Homo sapiens OX=9606 GN=CNNM3 PE=1 SV=1" "0.015" "False" "2.011" "1" "1" "1" "1" "707" "76.1" "6.09" "3.21" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf00571" "26505" "ENSG00000168763" "CNNM3" "B3KX67; hsa:26505; Q8NE01; Q8TBV4; Q96IW4; Q9NRK4; Q9NXW6" "" "2q11.2 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8306155883597695001" "False" "Medium" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "0.015" "False" "2.010" "4" "1" "1" "1" "273" "29.3" "8.18" "2.26" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "Ion transport by P-type ATPases" "" "1" "0" "1.036" "0.913" "1.161" "1.076" "0.947" "1.086" "0.824" "0.922" "0.997" "87.3" "90.4" "79.7" "101.4" "94.0" "82.7" "94.9" "72.0" "80.5" "87.1" "" "" "" "" "" "" "" "" "" "" "70.1" "65.3" "63.3" "67.9" "65.0" "62.1" "66.4" "52.6" "80.5" "70.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2087285006199939008" "False" "Medium" "IsMasterProtein" "P61626" "Lysozyme C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1" "0.016" "False" "2.005" "6" "1" "1" "1" "148" "16.5" "9.16" "2.19" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00062" "4069" "ENSG00000090382" "LYZ" "hsa:4069; P00695; P61626; Q13170; Q9UCF8" "Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides" "Macrophage markers; Pancreatic cancer subtypes" "5" "0" "14.726" "0.719" "0.295" "0.954" "0.673" "0.777" "0.817" "0.870" "1.022" "24.6" "362.9" "17.7" "7.3" "23.5" "16.6" "19.1" "20.1" "21.4" "25.2" "" "" "" "" "" "" "" "" "" "" "19.8" "261.8" "14.1" "4.9" "16.3" "12.4" "13.4" "14.7" "21.4" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5992266541679764687" "False" "Medium" "IsMasterProtein" "P30414" "NK-tumor recognition protein OS=Homo sapiens OX=9606 GN=NKTR PE=1 SV=2" "0.016" "False" "2.002" "0" "1" "1" "1" "1462" "165.6" "9.99" "3.01" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00160" "4820" "ENSG00000114857" "NKTR" "hsa:4820; P30414" "" "" "0" "0" "1.098" "1.154" "0.964" "0.861" "0.861" "0.857" "0.824" "0.982" "0.922" "294.4" "323.2" "339.8" "283.7" "253.5" "253.3" "252.1" "242.6" "289.0" "271.4" "" "" "" "" "" "" "" "" "" "" "236.4" "233.2" "269.9" "190.1" "175.3" "190.1" "176.5" "177.2" "289.0" "220.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366471573816439068" "False" "Medium" "IsMasterProtein" "P52179" "Myomesin-1 OS=Homo sapiens OX=9606 GN=MYOM1 PE=1 SV=2" "0.016" "False" "2.002" "1" "1" "5" "1" "1685" "187.5" "6.93" "12.79" "1" "developmental processes;signal transduction;other biological processes" "cytoskeleton" "other molecular function" "Pf00041, Pf07679" "8736" "ENSG00000101605" "MYOM1" "hsa:8736; P52179; Q14BD6; Q6H969; Q6ZUU0" "" "Striated muscle contraction pathway" "1" "0" "1.101" "1.075" "0.985" "0.946" "1.085" "0.855" "0.962" "1.073" "1.048" "205.2" "225.9" "220.7" "202.2" "194.2" "222.7" "175.5" "197.3" "220.1" "215.1" "" "" "" "" "" "" "" "" "" "" "164.8" "163.0" "175.3" "135.5" "134.3" "167.1" "122.8" "144.1" "220.1" "174.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "665460954492338555" "False" "Medium" "IsMasterProtein" "Q9NVR7" "TBCC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TBCCD1 PE=1 SV=1" "0.017" "False" "1.996" "2" "1" "1" "1" "557" "63.5" "8.69" "3.27" "1" "other biological processes" "cytoskeleton;other cell component" "" "Pf07986" "55171" "ENSG00000113838" "TBCCD1" "B3KW69; D3DNU6; G5E9J4; hsa:55171; Q9NVR7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3050786431982256186" "False" "Medium" "IsMasterProtein" "Q53ET0" "CREB-regulated transcription coactivator 2 OS=Homo sapiens OX=9606 GN=CRTC2 PE=1 SV=2" "0.017" "False" "1.988" "1" "1" "1" "1" "693" "73.3" "7.11" "2.14" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "200186" "ENSG00000160741" "CRTC2" "hsa:200186; Q53ET0; Q6UUV8; Q7Z3X7; Q8N332" "Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "5" "0" "1.103" "0.975" "0.876" "1.024" "0.938" "0.723" "0.809" "0.906" "1.001" "92.1" "101.6" "89.8" "80.7" "94.3" "86.4" "66.6" "74.5" "83.5" "92.2" "" "" "" "" "" "" "" "" "" "" "74.0" "73.3" "71.3" "54.1" "65.2" "64.8" "46.6" "54.4" "83.5" "75.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4250848831400251835" "False" "Medium" "IsMasterProtein" "Q96GY3" "Protein lin-37 homolog OS=Homo sapiens OX=9606 GN=LIN37 PE=1 SV=1" "0.017" "False" "1.980" "3" "1" "1" "1" "246" "28.4" "8.70" "2.75" "1" "other biological processes" "nucleus;other cell component" "" "Pf15306" "55957" "ENSG00000267796" "LIN37" "A8KAQ1; hsa:55957; O14557; Q7Z2T9; Q96GY3" "G1/S-Specific Transcription; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "DYRK1A involvement regarding cell proliferation in brain development" "8" "0" "1.065" "1.066" "1.088" "1.065" "0.957" "0.881" "1.063" "1.109" "1.102" "222.0" "236.4" "236.6" "241.4" "236.4" "212.4" "195.5" "236.0" "246.2" "244.6" "" "" "" "" "" "" "" "" "" "" "178.3" "170.5" "187.9" "161.8" "163.5" "159.4" "136.9" "172.3" "246.2" "198.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758268738613076417" "False" "Medium" "IsMasterProtein" "Q9HBM0" "Vezatin OS=Homo sapiens OX=9606 GN=VEZT PE=1 SV=3" "0.018" "False" "1.964" "1" "1" "1" "1" "779" "88.6" "5.20" "2.08" "1" "cell adhesion" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity" "Pf12632" "55591" "ENSG00000028203" "VEZT" "hsa:55591; Q6P1Q3; Q9H2F4; Q9H2U5; Q9HBM0; Q9NT70; Q9NVW0; Q9UF91" "" "" "0" "0" "0.926" "0.969" "0.976" "1.008" "0.637" "0.997" "0.824" "0.672" "0.801" "16.6" "15.4" "16.1" "16.2" "16.8" "10.6" "16.6" "13.7" "11.2" "13.3" "" "" "" "" "" "" "" "" "" "" "13.4" "11.1" "12.8" "10.9" "11.6" "8.0" "11.6" "10.0" "11.2" "10.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5196394549713774835" "False" "Medium" "IsMasterProtein" "Q69YU5" "Ubiquinol-cytochrome c reductase complex assembly factor 6 OS=Homo sapiens OX=9606 GN=UQCC6 PE=1 SV=2" "0.018" "False" "1.961" "10" "1" "1" "1" "71" "8.0" "9.16" "2.65" "1" "cell organization and biogenesis" "other membranes;mitochondrion" "" "Pf14990" "728568" "ENSG00000204954" "UQCC6" "hsa:728568; Q69YU5" "" "" "0" "0" "0.881" "0.910" "0.978" "0.992" "0.964" "0.883" "0.972" "0.974" "0.966" "314.3" "276.7" "285.9" "307.4" "311.8" "302.9" "277.6" "305.4" "306.2" "303.7" "" "" "" "" "" "" "" "" "" "" "252.4" "199.7" "227.1" "205.9" "215.7" "227.3" "194.4" "223.0" "306.2" "246.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7044477500846696439" "False" "Medium" "IsMasterProtein" "Q96DP5" "Methionyl-tRNA formyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=MTFMT PE=1 SV=2" "0.018" "False" "1.953" "2" "1" "1" "1" "389" "43.8" "9.66" "3.08" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00551, Pf02911" "123263" "ENSG00000103707" "MTFMT" "B7Z734; hsa:123263; Q96DP5" "Mitochondrial translation initiation" "One-carbon metabolism" "2" "0" "0.921" "0.877" "0.779" "0.817" "0.958" "0.770" "0.761" "1.015" "1.000" "160.5" "147.8" "140.7" "125.0" "131.1" "153.7" "123.6" "122.2" "162.9" "160.5" "" "" "" "" "" "" "" "" "" "" "128.9" "106.7" "111.8" "83.7" "90.7" "115.3" "86.5" "89.2" "162.9" "130.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "537430972224276465" "False" "Medium" "IsMasterProtein" "Q86SX3" "Tubulin epsilon and delta complex protein 1 OS=Homo sapiens OX=9606 GN=TEDC1 PE=1 SV=2" "0.018" "False" "1.950" "2" "1" "1" "1" "495" "54.2" "8.05" "3.54" "1" "other biological processes" "cytoskeleton;other cell component" "" "Pf14970" "283643" "ENSG00000185347" "TEDC1" "B5MDG3; E9PAQ4; hsa:283643; Q86SX3; Q86TT3; Q86TT4; Q86TT5; Q96B41; Q9H7H4" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "0.970" "0.761" "0.979" "0.910" "0.836" "0.763" "0.796" "0.934" "0.872" "149.5" "145.1" "113.8" "146.5" "136.0" "125.0" "114.0" "119.1" "139.7" "130.4" "" "" "" "" "" "" "" "" "" "" "120.1" "104.7" "90.4" "98.1" "94.1" "93.8" "79.8" "86.9" "139.7" "106.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7450881141775825578" "False" "Medium" "IsMasterProtein" "Q9H8W3" "Protein FAM204A OS=Homo sapiens OX=9606 GN=FAM204A PE=1 SV=1" "0.018" "False" "1.945" "4" "1" "1" "1" "233" "27.0" "7.91" "1.87" "1" "" "" "" "" "63877" "ENSG00000165669" "FAM204A" "D3DRC6; hsa:63877; Q5T373; Q9H5V5; Q9H8W3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6228343932262831473" "False" "Medium" "IsMasterProtein" "O43159" "Ribosomal RNA-processing protein 8 OS=Homo sapiens OX=9606 GN=RRP8 PE=1 SV=2" "0.018" "False" "1.944" "2" "1" "1" "1" "456" "50.7" "9.42" "3.21" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf05148" "23378" "ENSG00000132275" "RRP8" "hsa:23378; O43159; Q7KZ78; Q9BVM6" "SIRT1 negatively regulates rRNA expression" "" "1" "0" "1.108" "1.057" "1.179" "1.049" "1.053" "1.065" "1.046" "1.092" "1.149" "227.4" "252.0" "240.3" "268.0" "238.6" "239.5" "242.1" "237.9" "248.2" "261.2" "" "" "" "" "" "" "" "" "" "" "182.6" "181.8" "190.9" "179.6" "165.0" "179.7" "169.5" "173.7" "248.2" "212.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "813954222595635444" "False" "Medium" "IsMasterProtein" "Q9H668" "CST complex subunit STN1 OS=Homo sapiens OX=9606 GN=STN1 PE=1 SV=2" "0.018" "False" "1.942" "3" "1" "1" "1" "368" "42.1" "6.07" "2.71" "1" "cell organization and biogenesis;DNA metabolism;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf01336, Pf09170" "79991" "ENSG00000107960" "STN1" "D3DR99; hsa:79991; Q5TCZ0; Q9H668" "Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation" "Lung fibrosis" "3" "0" "0.907" "1.011" "0.977" "1.174" "0.821" "1.106" "1.126" "1.138" "1.068" "154.4" "140.1" "156.1" "150.8" "181.2" "126.7" "170.7" "173.9" "175.6" "164.9" "" "" "" "" "" "" "" "" "" "" "124.0" "101.1" "124.0" "101.1" "125.3" "95.1" "119.5" "127.0" "175.6" "134.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2848165254260814565" "False" "Medium" "IsMasterProtein" "Q6ZQQ2" "Spermatogenesis-associated protein 31D1 OS=Homo sapiens OX=9606 GN=SPATA31D1 PE=1 SV=1" "0.018" "False" "1.938" "1" "1" "1" "1" "1576" "175.5" "8.85" "2.72" "1" "other biological processes" "other membranes" "" "Pf14650, Pf15371" "389763" "ENSG00000214929" "SPATA31D1" "hsa:389763; Q6ZQQ2" "" "" "0" "0" "1.168" "1.055" "1.144" "0.928" "0.985" "0.800" "0.858" "1.027" "0.948" "178.3" "208.4" "188.1" "204.0" "165.5" "175.7" "142.7" "153.0" "183.1" "169.0" "" "" "" "" "" "" "" "" "" "" "143.2" "150.3" "149.4" "136.7" "114.5" "131.8" "99.9" "111.7" "183.1" "137.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6053253579863259654" "False" "Medium" "IsMasterProtein" "Q9P2M7" "Cingulin OS=Homo sapiens OX=9606 GN=CGN PE=1 SV=3" "0.018" "False" "1.936" "1" "1" "1" "1" "1203" "137.0" "5.52" "1.95" "1" "cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01576" "57530" "ENSG00000143375" "CGN" "A6H8L3; A7MD22; hsa:57530; Q5T386; Q9NR25; Q9P2M7" "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "15q11q13 copy number variation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2003482271588832905" "False" "Medium" "IsMasterProtein" "Q9H6N6" "Putative uncharacterized protein MYH16 OS=Homo sapiens OX=9606 GN=MYH16 PE=1 SV=2" "0.018" "False" "1.933" "1" "1" "1" "1" "1097" "128.2" "5.49" "2.02" "1" "" "cytoskeleton" "" "Pf01576" "" "" "MYH16" "Q9H6N6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8819989402744158112" "False" "Medium" "IsMasterProtein" "Q96EW2" "HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1" "0.019" "False" "1.925" "2" "1" "1" "1" "488" "55.1" "5.60" "2.36" "1" "" "other cell component" "other molecular function" "Pf13621" "79663" "ENSG00000169087" "HSPBAP1" "hsa:79663; Q6P476; Q8N8J4; Q8NHH6; Q8WWF0; Q96EW2" "" "" "0" "0" "0.871" "0.751" "1.025" "1.108" "0.851" "0.888" "0.961" "0.964" "0.935" "42.2" "36.7" "31.7" "43.3" "46.8" "35.9" "37.5" "40.6" "40.7" "39.5" "" "" "" "" "" "" "" "" "" "" "33.9" "26.5" "25.2" "29.0" "32.3" "26.9" "26.2" "29.6" "40.7" "32.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1762816792767039111" "False" "Medium" "IsMasterProtein" "Q9UJJ7" "RNA pseudouridylate synthase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RPUSD1 PE=1 SV=1" "0.019" "False" "1.914" "3" "1" "1" "1" "312" "34.7" "7.05" "2.29" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf00849" "113000" "ENSG00000007376" "RPUSD1" "D3DU66; hsa:113000; Q9UJJ7" "" "" "0" "0" "0.817" "0.653" "1.035" "0.855" "0.873" "0.650" "0.844" "0.849" "0.873" "31.3" "25.6" "20.5" "32.4" "26.8" "27.4" "20.4" "26.4" "26.6" "27.3" "" "" "" "" "" "" "" "" "" "" "25.2" "18.5" "16.3" "21.7" "18.5" "20.5" "14.3" "19.3" "26.6" "22.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2668394544474588816" "False" "Medium" "IsMasterProtein" "Q99470" "Stromal cell-derived factor 2 OS=Homo sapiens OX=9606 GN=SDF2 PE=1 SV=2" "0.019" "False" "1.914" "4" "1" "1" "1" "211" "23.0" "7.33" "3.13" "1" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf02815" "6388" "ENSG00000132581" "SDF2" "hsa:6388; Q99470; Q9BQ79" "" "" "0" "0" "0.964" "1.030" "1.337" "1.132" "1.163" "1.194" "1.121" "1.045" "1.094" "50.5" "48.7" "52.1" "67.6" "57.2" "58.8" "60.3" "56.7" "52.8" "55.3" "" "" "" "" "" "" "" "" "" "" "40.6" "35.2" "41.3" "45.3" "39.6" "44.1" "42.2" "41.4" "52.8" "44.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-574501495161686111" "False" "Medium" "IsMasterProtein" "Q9BSI4" "TERF1-interacting nuclear factor 2 OS=Homo sapiens OX=9606 GN=TINF2 PE=1 SV=1" "0.019" "False" "1.912" "2" "1" "1" "1" "451" "50.0" "7.96" "2.50" "1" "cell organization and biogenesis;DNA metabolism;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf14973" "26277" "ENSG00000092330; ENSG00000284915" "TINF2" "B3W5Q7; hsa:26277; Q9BSI4; Q9H904; Q9UHC2" "Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Removal of the Flap Intermediate from the C-strand; Telomere Extension By Telomerase; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation" "" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178980302497891247" "False" "Medium" "IsMasterProtein" "P29597" "Non-receptor tyrosine-protein kinase TYK2 OS=Homo sapiens OX=9606 GN=TYK2 PE=1 SV=3" "0.019" "False" "1.907" "1" "1" "1" "1" "1187" "133.6" "7.15" "0.00" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714, Pf17887, Pf18377, Pf18379" "7297" "ENSG00000105397" "TYK2" "hsa:7297; P29597; Q6QB10; Q96CH0" "Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Evasion by RSV of host interferon responses; Other interleukin signaling" "Type III interferon signaling; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL6 signaling pathway; IL-4 signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Th17 cell differentiation pathway; IL-26 signaling pathways; Interferon type I signaling pathways" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4735904607346551570" "False" "Medium" "IsMasterProtein" "P0C0L4" "Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2" "0.019" "False" "1.906" "0" "1" "1" "1" "1744" "192.7" "7.08" "2.76" "1" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791, Pf21145" "720; 721" "ENSG00000206340; ENSG00000227746; ENSG00000244731" "C4A" "A6H8M8; A6NHJ5; A7E2V2; B0QZR6; B0V2C8; B2RUT6; B7ZVZ6; hsa:720; hsa:721; P01028; P0C0L4; P78445; Q13160; Q13906; Q14033; Q14835; Q4LE82; Q5JNX2; Q5JQM8; Q6P4R1; Q6U2E5; Q6U2E8; Q6U2F0; Q6U2F3; Q6U2F4; Q6U2F6; Q6U2F8; Q6U2G0; Q96EG2; Q96SA8; Q9NPK5; Q9UIP5" "Initial triggering of complement; Regulation of Complement cascade; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Activation of C3 and C5" "Allograft rejection; Complement system; Dengue-2 interactions with complement and coagulation cascades; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058702091777146472" "False" "Medium" "IsMasterProtein" "Q9BQ65" "U6 snRNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=USB1 PE=1 SV=1" "0.019" "False" "1.906" "3" "1" "1" "1" "265" "30.2" "6.52" "2.22" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf09749" "79650" "ENSG00000103005" "USB1" "B4DWE3; B4DZW5; hsa:79650; Q96FZ9; Q9BQ65; Q9H8X8" "" "" "0" "0" "0.949" "1.131" "1.126" "0.897" "0.680" "1.425" "1.261" "0.977" "1.163" "22.4" "21.2" "25.3" "25.2" "20.1" "15.2" "31.9" "28.2" "21.9" "26.0" "" "" "" "" "" "" "" "" "" "" "18.0" "15.3" "20.1" "16.9" "13.9" "11.4" "22.3" "20.6" "21.9" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726538263945454181" "False" "Medium" "IsMasterProtein" "Q01459" "Di-N-acetylchitobiase OS=Homo sapiens OX=9606 GN=CTBS PE=1 SV=1" "0.020" "False" "1.904" "2" "1" "1" "1" "385" "43.7" "6.64" "2.14" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf00704" "1486" "ENSG00000117151" "CTBS" "hsa:1486; Q01459; Q5VX50" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6303332462308628979" "False" "Medium" "IsMasterProtein" "Q9NYY3" "Serine/threonine-protein kinase PLK2 OS=Homo sapiens OX=9606 GN=PLK2 PE=1 SV=3" "0.020" "False" "1.902" "1" "1" "1" "1" "685" "78.2" "8.24" "2.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00659" "10769" "ENSG00000145632" "PLK2" "hsa:10769; O60679; Q96CV7; Q9NYY3; Q9UE61" "NPAS4 regulates expression of target genes; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; CD163 mediating an anti-inflammatory response" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-161088924712109766" "False" "Medium" "IsMasterProtein" "Q96RU2" "Ubiquitin carboxyl-terminal hydrolase 28 OS=Homo sapiens OX=9606 GN=USP28 PE=1 SV=1" "0.020" "False" "1.902" "1" "1" "1" "1" "1077" "122.4" "5.20" "2.06" "1" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57646" "ENSG00000048028" "USP28" "B0YJC0; B0YJC1; hsa:57646; Q6NZX9; Q96RU2; Q9P213" "Ub-specific processing proteases" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4285948008108588428" "False" "Medium" "IsMasterProtein" "Q8N531" "F-box/LRR-repeat protein 6 OS=Homo sapiens OX=9606 GN=FBXL6 PE=1 SV=2" "0.020" "False" "1.899" "2" "1" "1" "1" "539" "58.5" "9.29" "2.03" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf12937" "26233" "ENSG00000182325; ENSG00000285442" "FBXL6" "hsa:26233; Q53G43; Q8N531; Q9H5W9; Q9UKC7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1010091006197829653" "False" "Medium" "IsMasterProtein" "Q9H1Z9" "Tetraspanin-10 OS=Homo sapiens OX=9606 GN=TSPAN10 PE=1 SV=1" "0.020" "False" "1.897" "2" "1" "1" "1" "355" "36.5" "5.86" "2.81" "1" "other biological processes" "other membranes" "other molecular function" "Pf00335" "83882" "" "TSPAN10" "hsa:83882; Q8N548; Q9H1Z9" "" "" "0" "0" "1.053" "1.007" "1.169" "1.012" "1.025" "1.088" "0.945" "1.081" "0.982" "94.4" "99.4" "95.1" "110.4" "95.5" "96.7" "102.7" "89.2" "102.0" "92.7" "" "" "" "" "" "" "" "" "" "" "75.8" "71.7" "75.5" "73.9" "66.1" "72.6" "71.9" "65.1" "102.0" "75.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4068487784358334043" "False" "Medium" "IsMasterProtein" "Q8TDX7" "Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1" "0.020" "False" "1.887" "3" "1" "1" "1" "302" "34.5" "8.25" "3.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "140609" "ENSG00000151414" "NEK7" "A6NGT8; hsa:140609; Q8TDX7" "Nuclear Pore Complex (NPC) Disassembly; EML4 and NUDC in mitotic spindle formation; Activation of NIMA Kinases NEK9, NEK6, NEK7" "Ciliary landscape; EPAC1 and PKA reduction of retinal inflammation" "5" "0" "0.942" "1.025" "1.046" "1.049" "1.062" "1.142" "1.107" "1.104" "1.084" "204.2" "192.4" "209.3" "213.7" "214.2" "217.0" "233.2" "226.2" "225.5" "221.5" "" "" "" "" "" "" "" "" "" "" "164.0" "138.9" "166.3" "143.2" "148.1" "162.8" "163.3" "165.2" "225.5" "180.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7399661987366055167" "False" "Medium" "IsMasterProtein" "O14713" "Integrin beta-1-binding protein 1 OS=Homo sapiens OX=9606 GN=ITGB1BP1 PE=1 SV=1" "0.020" "False" "1.886" "4" "1" "1" "1" "200" "21.8" "6.34" "3.22" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf10480" "9270" "ENSG00000119185" "ITGB1BP1" "D6W4Y9; hsa:9270; O14713; O14714; Q53RS0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "529818675588363220" "False" "Medium" "IsMasterProtein" "O95674" "Phosphatidate cytidylyltransferase 2 OS=Homo sapiens OX=9606 GN=CDS2 PE=1 SV=1" "0.020" "False" "1.884" "3" "1" "1" "1" "445" "51.4" "7.09" "1.62" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf01148" "8760" "ENSG00000101290" "CDS2" "B2RDC6; D3DW04; hsa:8760; O95674; Q5TDY2; Q5TDY3; Q5TDY4; Q5TDY5; Q9BYK5; Q9NTT2" "Synthesis of PG" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "301358468998161608" "False" "Medium" "IsMasterProtein" "Q96PE1" "Adhesion G protein-coupled receptor A2 OS=Homo sapiens OX=9606 GN=ADGRA2 PE=1 SV=2" "0.020" "False" "1.881" "1" "1" "2" "1" "1338" "142.6" "8.44" "4.65" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00002, Pf01825, Pf13855" "25960" "ENSG00000020181" "ADGRA2" "A6H8W3; D3DSW4; hsa:25960; Q8N3R1; Q8TEM3; Q96KB2; Q96PE1; Q9P1Z7; Q9UFY4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927192011377040522" "False" "Medium" "IsMasterProtein" "Q2NL68" "Proline and serine-rich protein 3 OS=Homo sapiens OX=9606 GN=PROSER3 PE=1 SV=1" "0.020" "False" "1.881" "2" "1" "1" "1" "480" "51.0" "7.14" "2.79" "1" "" "cytoskeleton;other cell component" "" "" "148137" "ENSG00000167595" "PROSER3" "hsa:148137; Q2NL68; Q8NDI3; Q8WWC8; Q96NL4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621836974049986451" "False" "Medium" "IsMasterProtein" "Q9Y3E7" "Charged multivesicular body protein 3 OS=Homo sapiens OX=9606 GN=CHMP3 PE=1 SV=3" "0.020" "False" "1.876" "3" "1" "1" "1" "222" "25.1" "5.12" "2.17" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "100526767; 51652" "ENSG00000115561" "CHMP3" "A8K3W0; B4DG34; B8ZZM0; B8ZZX5; hsa:100526767; hsa:51652; Q3ZTS9; Q53S71; Q53SU5; Q9NZ51; Q9Y3E7" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502967859267894039" "False" "Medium" "IsMasterProtein" "P62068" "Ubiquitin carboxyl-terminal hydrolase 46 OS=Homo sapiens OX=9606 GN=USP46 PE=1 SV=1" "0.020" "False" "1.875" "2" "1" "1" "1" "366" "42.4" "6.83" "3.01" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "64854" "ENSG00000109189" "USP46" "B7Z3Y7; B7Z675; B7Z7S3; G8ACC7; hsa:64854; P62068; Q80V95; Q9H7U4; Q9H9T8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107037615117632570" "False" "Medium" "IsMasterProtein" "P07992" "DNA excision repair protein ERCC-1 OS=Homo sapiens OX=9606 GN=ERCC1 PE=1 SV=1" "0.020" "False" "1.870" "4" "1" "1" "1" "297" "32.5" "6.25" "1.93" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00633, Pf03834" "2067" "ENSG00000012061" "ERCC1" "B2RC01; B3KRR0; hsa:2067; P07992; Q7Z7F5; Q96S40" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4979023771098878590" "False" "Medium" "IsMasterProtein" "Q9Y4P3" "Transducin beta-like protein 2 OS=Homo sapiens OX=9606 GN=TBL2 PE=1 SV=1" "0.020" "False" "1.866" "2" "1" "1" "1" "447" "49.8" "9.44" "2.48" "1" "stress response;signal transduction" "other membranes;ER/Golgi" "other molecular function" "Pf00400" "26608" "ENSG00000106638" "TBL2" "hsa:26608; Q9UQE2; Q9Y4P3" "" "7q11.23 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3237045866174408172" "False" "Medium" "IsMasterProtein" "Cont_P20930" "Filaggrin OS=Homo sapiens OX=9606 GN=FLG PE=1 SV=3" "0.020" "True" "1.866" "0" "1" "1" "1" "4061" "434.9" "9.25" "3.01" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf01023, Pf03516" "2312" "ENSG00000143631" "FLG" "hsa:2312; P20930; Q01720; Q5T583; Q9UC71" "Formation of the cornified envelope" "" "1" "0" "0.722" "0.221" "0.482" "0.831" "1.484" "0.940" "1.125" "0.869" "0.840" "54.5" "39.3" "12.1" "26.3" "45.3" "80.9" "51.2" "61.3" "47.3" "45.8" "" "" "" "" "" "" "" "" "" "" "43.8" "28.4" "9.6" "17.6" "31.3" "60.7" "35.9" "44.8" "47.3" "37.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3560652470776637886" "False" "Medium" "IsMasterProtein" "O43567" "E3 ubiquitin-protein ligase RNF13 OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1" "0.020" "False" "1.865" "2" "1" "1" "1" "381" "42.8" "4.98" "3.49" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02225, Pf13639" "11342" "ENSG00000082996" "RNF13" "A6NC87; B3KR12; hsa:11342; O43567; Q05D66; Q6IBJ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-300411415202382779" "False" "Medium" "IsMasterProtein" "Q96NB1" "Centrosomal protein 20 OS=Homo sapiens OX=9606 GN=CEP20 PE=1 SV=1" "0.020" "False" "1.862" "5" "1" "1" "1" "174" "19.8" "7.15" "0.00" "1" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf09398" "123811" "ENSG00000133393; ENSG00000276914" "CEP20" "B3KPU9; hsa:123811; Q96NB1" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6830968360322984650" "False" "Medium" "IsMasterProtein" "Q9BTV6" "Diphthine methyltransferase OS=Homo sapiens OX=9606 GN=DPH7 PE=1 SV=2" "0.020" "False" "1.860" "3" "1" "1" "1" "452" "50.5" "6.60" "1.69" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00400" "92715" "ENSG00000148399" "DPH7" "hsa:92715; Q96AB7; Q9BTV6" "Synthesis of diphthamide-EEF2" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3586034237824916844" "False" "Medium" "IsMasterProtein" "P11117" "Lysosomal acid phosphatase OS=Homo sapiens OX=9606 GN=ACP2 PE=1 SV=3" "0.020" "False" "1.859" "3" "1" "1" "1" "423" "48.3" "6.74" "2.18" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00328" "53" "ENSG00000134575" "ACP2" "E9PCI1; hsa:53; P11117; Q561W5; Q9BTU7" "" "" "0" "0" "1.038" "1.137" "1.128" "1.255" "1.651" "1.215" "1.078" "1.121" "1.138" "18.3" "19.0" "20.8" "20.6" "22.9" "30.1" "22.2" "19.7" "20.5" "20.8" "" "" "" "" "" "" "" "" "" "" "14.7" "13.7" "16.5" "13.8" "15.8" "22.6" "15.5" "14.4" "20.5" "16.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7789640174005982269" "False" "Medium" "IsMasterProtein" "Q9Y5R2" "Matrix metalloproteinase-24 OS=Homo sapiens OX=9606 GN=MMP24 PE=1 SV=1" "0.020" "False" "1.857" "2" "1" "1" "1" "645" "73.2" "9.23" "0.00" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00045, Pf00413, Pf01471, Pf11857" "10893" "ENSG00000125966" "MMP24" "B7ZBG8; hsa:10893; Q9H440; Q9Y5R2" "Activation of Matrix Metalloproteinases" "Matrix metalloproteinases; Chronic hyperglycemia impairment of neuron function" "3" "0" "1.122" "1.281" "1.028" "1.192" "1.060" "0.694" "0.851" "1.183" "1.117" "15.7" "17.7" "20.2" "16.2" "18.8" "16.7" "10.9" "13.4" "18.6" "17.6" "" "" "" "" "" "" "" "" "" "" "12.6" "12.7" "16.0" "10.8" "13.0" "12.5" "7.7" "9.8" "18.6" "14.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984281592385059565" "False" "Medium" "IsMasterProtein" "Q6ZU35" "Capping protein-inhibiting regulator of actin dynamics OS=Homo sapiens OX=9606 GN=CRACD PE=1 SV=3" "0.020" "False" "1.854" "1" "1" "1" "1" "1233" "136.7" "5.60" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytosol" "" "Pf15262" "57482" "ENSG00000109265" "CRACD" "hsa:57482; Q6ZU35; Q9NTE2; Q9NTP8; Q9ULK9" "" "" "0" "0" "1.008" "1.039" "1.350" "0.978" "1.135" "1.225" "1.006" "1.122" "1.017" "22.4" "22.5" "23.2" "30.2" "21.9" "25.4" "27.4" "22.5" "25.1" "22.7" "" "" "" "" "" "" "" "" "" "" "18.0" "16.3" "18.4" "20.2" "15.1" "19.0" "19.2" "16.4" "25.1" "18.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4243289902252948074" "False" "Medium" "IsMasterProtein" "Q9NPG1" "Frizzled-3 OS=Homo sapiens OX=9606 GN=FZD3 PE=1 SV=1" "0.021" "False" "1.838" "1" "1" "1" "1" "666" "76.2" "7.74" "2.54" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01392, Pf01534" "7976" "ENSG00000104290" "FZD3" "A8K615; hsa:7976; Q9NPG1" "Asymmetric localization of PCP proteins; Class B/2 (Secretin family receptors); Ca2+ pathway" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Pleural mesothelioma; Alzheimer's disease" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8514110242710764604" "False" "Medium" "IsMasterProtein" "P48553" "Trafficking protein particle complex subunit 10 OS=Homo sapiens OX=9606 GN=TRAPPC10 PE=1 SV=2" "0.021" "False" "1.835" "1" "1" "1" "1" "1259" "142.1" "6.04" "2.06" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf12584" "7109" "ENSG00000160218" "TRAPPC10" "hsa:7109; P48553; Q3MIR2; Q86SI7; Q9UMD4; Q9Y4L3" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-632220125503920335" "False" "Medium" "IsMasterProtein" "Q6PII5" "Hydroxyacylglutathione hydrolase-like protein OS=Homo sapiens OX=9606 GN=HAGHL PE=1 SV=1" "0.021" "False" "1.832" "3" "1" "1" "1" "290" "31.5" "8.21" "0.00" "1" "" "" "other molecular function" "Pf00753" "84264" "ENSG00000103253" "HAGHL" "A6NCC4; D3DU64; hsa:84264; Q59FX8; Q6PII5; Q96BZ3; Q96NR5; Q96S11; Q9BT45" "" "Orexin receptor pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6300831258650065566" "False" "Medium" "IsMasterProtein" "Q9P281" "BAH and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BAHCC1 PE=1 SV=4" "0.021" "False" "1.828" "0" "1" "1" "1" "2639" "279.8" "8.78" "2.96" "1" "" "" "other molecular function" "Pf01426, Pf21744" "57597" "ENSG00000266074" "BAHCC1" "A0A075B747; hsa:57597; Q5U629; Q9P281" "" "" "0" "0" "0.924" "1.145" "1.101" "0.828" "0.787" "0.921" "0.836" "0.829" "0.827" "49.4" "45.7" "56.6" "54.4" "40.9" "38.9" "45.5" "41.3" "41.0" "40.9" "" "" "" "" "" "" "" "" "" "" "39.7" "32.9" "44.9" "36.5" "28.3" "29.2" "31.9" "30.2" "41.0" "33.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7529344055509267771" "False" "Medium" "IsMasterProtein" "Q96T83" "Sodium/hydrogen exchanger 7 OS=Homo sapiens OX=9606 GN=SLC9A7 PE=1 SV=1" "0.021" "False" "1.827" "1" "1" "1" "1" "725" "80.1" "6.42" "1.94" "1" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf00999" "84679" "ENSG00000065923" "SLC9A7" "hsa:84679; O75827; Q5JXP9; Q96T83" "Sodium/Proton exchangers" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4349048181346245429" "False" "Medium" "IsMasterProtein" "Q9Y6B7" "AP-4 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP4B1 PE=1 SV=2" "0.021" "False" "1.818" "1" "1" "1" "1" "739" "83.2" "5.86" "0.00" "1" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf09066" "10717" "ENSG00000134262" "AP4B1" "B7Z4X3; hsa:10717; Q59EJ4; Q96CL6; Q9Y6B7" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4373504798127132024" "False" "Medium" "IsMasterProtein" "Q8IYJ3" "Synaptotagmin-like protein 1 OS=Homo sapiens OX=9606 GN=SYTL1 PE=1 SV=1" "0.021" "False" "1.812" "2" "1" "1" "1" "562" "61.8" "5.48" "0.00" "1" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168" "84958" "ENSG00000142765" "SYTL1" "hsa:84958; Q5SSC9; Q8IYJ3; Q96BB6; Q96GU6; Q96S89; Q96SI0" "TBC/RABGAPs" "Deregulation of Rab and Rab effector genes in bladder cancer" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4851330478583605955" "False" "Medium" "IsMasterProtein" "Q92802" "NEDD4-binding protein 2-like 2 OS=Homo sapiens OX=9606 GN=N4BP2L2 PE=1 SV=1" "0.021" "False" "1.809" "2" "1" "2" "1" "583" "67.4" "6.39" "0.00" "1" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13671" "10443" "ENSG00000244754" "N4BP2L2" "A3KME8; hsa:10443; Q92802" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "796383816243011669" "False" "Medium" "IsMasterProtein" "O43513" "Mediator of RNA polymerase II transcription subunit 7 OS=Homo sapiens OX=9606 GN=MED7 PE=1 SV=1" "0.021" "False" "1.808" "9" "1" "2" "1" "233" "27.2" "5.78" "0.00" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05983" "9443" "ENSG00000155868" "MED7" "hsa:9443; O43513" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "High" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-1356294083817366214" "False" "Medium" "IsMasterProtein" "Q96HM7" "PC-esterase domain-containing protein 1B OS=Homo sapiens OX=9606 GN=PCED1B PE=1 SV=1" "0.021" "False" "1.806" "2" "1" "1" "1" "432" "49.7" "9.52" "3.20" "1" "" "" "" "" "91523" "ENSG00000179715" "PCED1B" "hsa:91523; Q96B20; Q96HM7" "" "" "0" "0" "1.081" "1.112" "1.166" "1.165" "1.026" "1.128" "1.173" "1.091" "1.082" "176.7" "191.0" "196.5" "206.0" "206.0" "181.3" "199.4" "207.4" "192.8" "191.2" "" "" "" "" "" "" "" "" "" "" "142.0" "137.8" "156.1" "138.0" "142.5" "136.0" "139.6" "151.4" "192.8" "155.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6526691587198802025" "False" "Medium" "IsMasterProtein" "P59780" "AP-3 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP3S2 PE=1 SV=1" "0.021" "False" "1.803" "6" "1" "1" "1" "193" "22.0" "5.22" "1.87" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "10239" "ENSG00000157823" "AP3S2" "B2R677; B4DGQ3; hsa:10239; O09077; O09149; P59780; Q53H83; Q99589" "" "" "0" "0" "1.092" "1.047" "1.279" "1.203" "1.231" "1.314" "1.495" "1.079" "1.512" "21.3" "23.3" "22.3" "27.3" "25.6" "26.2" "28.0" "31.9" "23.0" "32.2" "" "" "" "" "" "" "" "" "" "" "17.1" "16.8" "17.7" "18.3" "17.7" "19.7" "19.6" "23.3" "23.0" "26.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4640112116158414629" "False" "Medium" "IsMasterProtein" "Q9H2A9" "Carbohydrate sulfotransferase 8 OS=Homo sapiens OX=9606 GN=CHST8 PE=1 SV=2" "0.021" "False" "1.793" "3" "1" "1" "1" "424" "48.8" "10.17" "3.08" "1" "protein metabolism;other metabolic processes;developmental processes" "other membranes;ER/Golgi" "other molecular function" "Pf03567" "64377" "ENSG00000124302" "CHST8" "hsa:64377; Q9H2A9; Q9H3N2" "Reactions specific to the complex N-glycan synthesis pathway" "Metapathway biotransformation Phase I and II" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3685684818087556165" "False" "Medium" "IsMasterProtein" "P49755" "Transmembrane emp24 domain-containing protein 10 OS=Homo sapiens OX=9606 GN=TMED10 PE=1 SV=2" "0.021" "False" "1.793" "4" "1" "1" "1" "219" "25.0" "7.44" "2.45" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf01105" "10972" "ENSG00000170348" "TMED10" "B2R605; hsa:10972; P49755; Q15602; Q16536; Q86TC2; Q86TS5" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; Cargo concentration in the ER" "mRNA processing; 5q35 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8170052287552769839" "False" "Medium" "IsMasterProtein" "Q13905" "Rap guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=RAPGEF1 PE=1 SV=3" "0.021" "False" "1.789" "1" "1" "1" "1" "1077" "120.5" "5.92" "2.55" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00617, Pf00618" "2889" "ENSG00000107263" "RAPGEF1" "hsa:2889; Q13905; Q5JUE4; Q68DL3; Q8IV73" "RAC3 GTPase cycle; Regulation of signaling by CBL; Downstream signal transduction; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MET in type 1 papillary renal cell carcinoma; Insulin signaling; Interferon type I signaling pathways" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5297108689018783093" "False" "Medium" "IsMasterProtein" "Q9HAP2" "MLX-interacting protein OS=Homo sapiens OX=9606 GN=MLXIP PE=1 SV=2" "0.021" "False" "1.788" "2" "1" "1" "1" "919" "101.1" "8.35" "1.76" "1" "other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "22877" "ENSG00000175727; ENSG00000281178" "MLXIP" "A7MBN0; hsa:22877; O94945; Q7LC47; Q8IXP1; Q8TAH9; Q8WVQ0; Q8WYA5; Q9HAP2" "" "Nonalcoholic fatty liver disease" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4298785526974998210" "False" "Medium" "IsMasterProtein" "Q9BTU6" "Phosphatidylinositol 4-kinase type 2-alpha OS=Homo sapiens OX=9606 GN=PI4K2A PE=1 SV=1" "0.021" "False" "1.788" "2" "1" "2" "1" "479" "54.0" "8.29" "0.00" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454" "55361" "ENSG00000155252" "PI4K2A" "D3DR59; hsa:55361; Q9BTU6; Q9NSG8" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the plasma membrane" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Wnt signaling pathway" "5" "0" "0.807" "0.894" "0.794" "1.328" "0.954" "1.501" "1.006" "1.221" "1.203" "15.2" "12.3" "13.6" "12.1" "20.2" "14.5" "22.9" "15.3" "18.6" "18.3" "" "" "" "" "" "" "" "" "" "" "12.2" "8.9" "10.8" "8.1" "14.0" "10.9" "16.0" "11.2" "18.6" "14.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229500280398030060" "False" "Medium" "IsMasterProtein" "Q9Y2E5" "Epididymis-specific alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B2 PE=1 SV=4" "0.021" "False" "1.785" "1" "1" "1" "1" "1009" "113.9" "7.24" "2.73" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf01074, Pf07748, Pf09261" "23324" "ENSG00000013288" "MAN2B2" "hsa:23324; Q66MP2; Q86T67; Q9Y2E5" "Lysosomal oligosaccharide catabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923861490419149454" "False" "Medium" "IsMasterProtein" "Q86UA6" "RPA-interacting protein OS=Homo sapiens OX=9606 GN=RPAIN PE=1 SV=2" "0.022" "False" "1.779" "3" "1" "1" "1" "219" "24.8" "4.87" "2.99" "1" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf14766, Pf14767, Pf14768" "84268" "ENSG00000129197" "RPAIN" "A0A0B4J1T3; B4DI36; B4DTX7; E9PDG9; E9PES3; J3KNH8; Q4G2Y0; Q4G2Y5; Q4G2Y8; Q6B4V9; Q6B4W0; Q6B4W1; Q6B4W4; Q86UA6; Q86X49; Q9BT00" "" "" "0" "0" "1.136" "1.036" "0.977" "0.977" "0.979" "0.965" "1.005" "1.089" "1.100" "233.2" "264.9" "241.5" "227.9" "227.8" "228.5" "225.0" "234.4" "254.0" "256.5" "" "" "" "" "" "" "" "" "" "" "187.3" "191.1" "191.9" "152.7" "157.6" "171.4" "157.6" "171.2" "254.0" "208.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376018715288755929" "False" "Medium" "IsMasterProtein" "O95249" "Golgi SNAP receptor complex member 1 OS=Homo sapiens OX=9606 GN=GOSR1 PE=1 SV=1" "0.022" "False" "1.779" "3" "1" "1" "1" "250" "28.6" "9.42" "3.01" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf12352" "9527" "ENSG00000108587" "GOSR1" "hsa:9527; J3KST5; O75392; O95249" "COPI-mediated anterograde transport; Intra-Golgi traffic" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6680775627371570044" "False" "Medium" "IsMasterProtein" "Q9Y6V0" "Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5" "0.022" "False" "1.776" "0" "1" "1" "1" "5142" "560.4" "6.47" "3.19" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00168, Pf00595, Pf05715" "27445" "ENSG00000186472" "PCLO" "A4D1A7; A6NNX9; O43373; O60305; Q08E72; Q9BVC8; Q9UIV2; Q9Y6U9; Q9Y6V0" "Sensory processing of sound by inner hair cells of the cochlea" "Cell lineage map for neuronal differentiation" "2" "0" "0.967" "0.951" "1.125" "1.024" "1.070" "1.086" "0.798" "0.978" "1.078" "111.9" "108.2" "106.5" "125.9" "114.5" "119.8" "121.6" "89.3" "109.4" "120.6" "" "" "" "" "" "" "" "" "" "" "89.9" "78.0" "84.6" "84.4" "79.2" "89.9" "85.1" "65.2" "109.4" "98.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6176410961919918539" "False" "Medium" "IsMasterProtein" "Q96QP1" "Alpha-protein kinase 1 OS=Homo sapiens OX=9606 GN=ALPK1 PE=1 SV=3" "0.022" "False" "1.770" "1" "1" "1" "1" "1244" "138.8" "6.24" "2.64" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf02816" "80216" "ENSG00000073331" "ALPK1" "B4E3G1; F5H138; hsa:80216; Q68CI9; Q6P9F9; Q6ZNK4; Q96QP1; Q9P201" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857975298597403350" "False" "Medium" "IsMasterProtein" "Q96N67" "Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4" "0.022" "False" "1.765" "0" "1" "2" "1" "2140" "242.4" "6.80" "6.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "85440" "ENSG00000116641" "DOCK7" "hsa:85440; Q00M63; Q2PPY7; Q45RE8; Q45RE9; Q5T1B9; Q5T1C0; Q6ZV32; Q8TB82; Q96N67; Q96NG6; Q96NI0; Q9C092" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production; MET activates RAP1 and RAC1" "" "4" "0" "0.849" "0.896" "0.880" "0.936" "0.845" "0.903" "0.864" "0.844" "0.781" "91.9" "78.0" "82.3" "80.9" "86.0" "77.7" "83.0" "79.5" "77.6" "71.8" "" "" "" "" "" "" "" "" "" "" "73.8" "56.3" "65.4" "54.2" "59.5" "58.3" "58.1" "58.0" "77.6" "58.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6233327250994460082" "False" "Medium" "IsMasterProtein" "Q96HU1" "Small G protein signaling modulator 3 OS=Homo sapiens OX=9606 GN=SGSM3 PE=1 SV=1" "0.022" "False" "1.764" "1" "1" "1" "1" "749" "85.3" "6.00" "3.07" "1" "cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00566, Pf02759" "27352" "ENSG00000100359" "SGSM3" "B0QY79; hsa:27352; Q7Z709; Q96HU1; Q9NT69" "" "Ectoderm differentiation; Ectoderm differentiation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7295349075853767630" "False" "Medium" "IsMasterProtein" "Q1MSJ5" "Centrosome and spindle pole-associated protein 1 OS=Homo sapiens OX=9606 GN=CSPP1 PE=1 SV=4" "0.022" "False" "1.764" "1" "1" "1" "1" "1256" "145.4" "6.80" "1.99" "1" "other biological processes" "cytoskeleton;other cell component" "" "" "79848" "ENSG00000104218" "CSPP1" "A6ND63; hsa:79848; Q1MSJ5; Q70F00; Q8TBC1" "" "Joubert syndrome; Ciliopathies" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4922991929766988282" "False" "Medium" "IsMasterProtein" "Q99607" "ETS-related transcription factor Elf-4 OS=Homo sapiens OX=9606 GN=ELF4 PE=1 SV=1" "0.023" "False" "1.754" "1" "1" "1" "1" "663" "70.7" "5.60" "2.09" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "2000" "ENSG00000102034" "ELF4" "D3DTG1; hsa:2000; O60435; Q99607" "" "TYROBP causal network in microglia" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8481901150612676227" "False" "Medium" "IsMasterProtein" "Q9NPH3" "Interleukin-1 receptor accessory protein OS=Homo sapiens OX=9606 GN=IL1RAP PE=1 SV=2" "0.023" "False" "1.753" "1" "1" "1" "1" "570" "65.4" "8.12" "2.77" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01582, Pf18452" "3556" "ENSG00000196083" "IL1RAP" "B1NLD0; D3DNW0; hsa:3556; O14915; Q86WJ7; Q9NPH3" "" "IL-1 signaling pathway; Interleukin-1 (IL-1) structural pathway; Signal transduction through IL1R; 2q13 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-501406145012788137" "False" "Medium" "IsMasterProtein" "Q9H2K0" "Translation initiation factor IF-3, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF3 PE=1 SV=4" "0.023" "False" "1.749" "3" "1" "1" "1" "278" "31.7" "9.69" "2.54" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf05198" "219402" "ENSG00000122033" "MTIF3" "hsa:219402; Q05BL8; Q5W0V0; Q86X68; Q9H2K0" "Mitochondrial translation initiation" "" "1" "0" "0.970" "1.160" "1.194" "1.059" "1.162" "0.862" "0.941" "0.924" "1.057" "90.1" "87.4" "104.5" "107.6" "95.4" "104.7" "77.6" "84.8" "83.2" "95.2" "" "" "" "" "" "" "" "" "" "" "72.4" "63.0" "83.0" "72.1" "66.0" "78.5" "54.4" "61.9" "83.2" "77.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1543247318487968037" "False" "Medium" "IsMasterProtein" "Q96GN5" "Cell division cycle-associated 7-like protein OS=Homo sapiens OX=9606 GN=CDCA7L PE=1 SV=2" "0.023" "False" "1.744" "2" "1" "1" "1" "454" "52.2" "5.74" "1.84" "1" "other biological processes" "cytosol;nucleus" "" "Pf10497" "55536" "ENSG00000164649" "CDCA7L" "A4D141; A6NF50; B3KTR5; B4DUT3; C9K0Y1; hsa:55536; Q6PIL4; Q86YT0; Q8IXN5; Q96C70; Q96GN5; Q9H9A2; Q9NPV2" "" "Sudden infant death syndrome (SIDS) susceptibility pathways" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3490991347050641114" "False" "Medium" "IsMasterProtein" "Q9H9A7" "RecQ-mediated genome instability protein 1 OS=Homo sapiens OX=9606 GN=RMI1 PE=1 SV=3" "0.023" "False" "1.743" "1" "1" "1" "1" "625" "70.1" "4.96" "3.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08585, Pf16099, Pf21000" "80010" "ENSG00000178966" "RMI1" "hsa:80010; Q05BX1; Q05CW3; Q5SQG8; Q5SQG9; Q6P1Q4; Q6PI89; Q7Z6L6; Q9H9A7" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "" "14" "0" "0.944" "0.929" "0.934" "0.958" "0.959" "0.915" "0.871" "1.009" "1.043" "215.1" "203.2" "199.9" "200.9" "206.1" "206.2" "196.8" "187.4" "217.1" "224.4" "" "" "" "" "" "" "" "" "" "" "172.8" "146.6" "158.8" "134.6" "142.5" "154.7" "137.8" "136.9" "217.1" "182.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2254407598464366053" "False" "Medium" "IsMasterProtein" "Q13467" "Frizzled-5 OS=Homo sapiens OX=9606 GN=FZD5 PE=1 SV=2" "0.023" "False" "1.738" "3" "1" "1" "1" "585" "64.5" "8.29" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01392, Pf01534" "7855" "ENSG00000163251" "FZD5" "A8K2X1; B2RCZ1; hsa:7855; Q13467; Q53R22" "Asymmetric localization of PCP proteins; Class B/2 (Secretin family receptors); Ca2+ pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants; WNT5A-dependent internalization of FZD2, FZD5 and ROR2" "Alzheimer's disease and miRNA effects; Mesodermal commitment pathway; Ectoderm differentiation; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Pleural mesothelioma; Alzheimer's disease" "22" "0" "0.759" "0.859" "1.012" "1.215" "0.820" "0.729" "1.009" "1.568" "0.867" "14.1" "10.7" "12.1" "14.2" "17.1" "11.5" "10.3" "14.2" "22.1" "12.2" "" "" "" "" "" "" "" "" "" "" "11.3" "7.7" "9.6" "9.5" "11.8" "8.7" "7.2" "10.4" "22.1" "9.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5201003566343787009" "False" "Medium" "IsMasterProtein" "P62273" "Small ribosomal subunit protein uS14 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2" "0.024" "False" "1.737" "11" "1" "1" "1" "56" "6.7" "10.13" "2.17" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00253" "6235" "ENSG00000213741" "RPS29" "A8MZ73; hsa:6235; P30054; P62273" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1999120718507000118" "False" "Medium" "IsMasterProtein" "P17707" "S-adenosylmethionine decarboxylase proenzyme OS=Homo sapiens OX=9606 GN=AMD1 PE=1 SV=2" "0.024" "False" "1.735" "4" "1" "1" "1" "334" "38.3" "6.00" "2.35" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01536" "262" "ENSG00000123505" "AMD1" "E1P5F7; hsa:262; P17707; Q5VXN4; Q5VXN6; Q9BWK4" "Metabolism of polyamines" "Methionine de novo and salvage pathway" "2" "0" "1.305" "1.124" "1.074" "1.159" "1.084" "1.413" "1.411" "1.210" "1.516" "11.4" "14.8" "12.8" "12.2" "13.2" "12.3" "16.1" "16.1" "13.8" "17.2" "" "" "" "" "" "" "" "" "" "" "9.1" "10.7" "10.2" "8.2" "9.1" "9.3" "11.3" "11.7" "13.8" "14.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735333771594595677" "False" "Medium" "IsMasterProtein" "Q9BYN8" "Small ribosomal subunit protein mS26 OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" "0.024" "False" "1.734" "4" "1" "1" "1" "205" "24.2" "10.39" "2.22" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf14943" "64949" "ENSG00000125901" "MRPS26" "hsa:64949; Q96Q58; Q9BYN8" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.989" "0.849" "1.080" "1.075" "0.889" "0.998" "1.029" "0.970" "1.007" "101.1" "100.0" "85.9" "109.2" "108.7" "89.9" "100.9" "104.0" "98.0" "101.8" "" "" "" "" "" "" "" "" "" "" "81.2" "72.1" "68.2" "73.2" "75.2" "67.4" "70.6" "76.0" "98.0" "82.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6366529207775164370" "False" "Medium" "IsMasterProtein" "Q15198" "Platelet-derived growth factor receptor-like protein OS=Homo sapiens OX=9606 GN=PDGFRL PE=1 SV=1" "0.024" "False" "1.727" "2" "1" "1" "1" "375" "41.8" "8.50" "2.93" "1" "signal transduction" "non-structural extracellular" "kinase activity;other molecular function" "Pf13927, Pf21339" "5157" "ENSG00000104213" "PDGFRL" "A8K085; hsa:5157; Q15198; Q6FH04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6395049123037932349" "False" "Medium" "IsMasterProtein" "P30793" "GTP cyclohydrolase 1 OS=Homo sapiens OX=9606 GN=GCH1 PE=1 SV=1" "0.024" "False" "1.724" "3" "1" "1" "1" "250" "27.9" "8.56" "3.10" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01227" "2643" "ENSG00000131979" "GCH1" "hsa:2643; P30793; Q6FHY7; Q9Y4I8" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "Ferroptosis" "2" "0" "0.995" "1.048" "0.991" "0.928" "0.945" "1.104" "1.138" "1.114" "1.029" "241.2" "239.9" "252.7" "239.1" "223.9" "227.8" "266.4" "274.5" "268.6" "248.3" "" "" "" "" "" "" "" "" "" "" "193.7" "173.1" "200.8" "160.2" "154.8" "170.9" "186.5" "200.5" "268.6" "201.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6288019369957084060" "False" "Medium" "IsMasterProtein" "Q99550" "M-phase phosphoprotein 9 OS=Homo sapiens OX=9606 GN=MPHOSPH9 PE=1 SV=7" "0.024" "False" "1.722" "1" "1" "1" "1" "1183" "132.9" "6.24" "0.00" "1" "other biological processes" "other membranes;cytoskeleton;ER/Golgi" "" "" "10198" "ENSG00000051825" "MPHOSPH9" "A0A0A0MTP3; A1L486; A6NEE2; B3KR87; hsa:10198; Q99550; Q9H976; U3KQ28" "" "" "0" "0" "0.659" "0.605" "0.807" "0.479" "0.604" "0.833" "1.018" "0.993" "0.650" "17.6" "11.6" "10.6" "14.2" "8.4" "10.6" "14.6" "17.9" "17.4" "11.4" "" "" "" "" "" "" "" "" "" "" "14.1" "8.3" "8.4" "9.5" "5.8" "8.0" "10.2" "13.0" "17.4" "9.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864324901755663317" "False" "Medium" "IsMasterProtein" "Q8TAP9" "M-phase-specific PLK1-interacting protein OS=Homo sapiens OX=9606 GN=MPLKIP PE=1 SV=1" "0.025" "False" "1.719" "5" "1" "1" "1" "179" "19.1" "10.23" "3.08" "1" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf15502" "136647" "ENSG00000168303" "MPLKIP" "hsa:136647; Q8TAP9" "" "" "0" "0" "0.847" "0.910" "1.004" "1.024" "0.944" "0.872" "1.020" "0.819" "0.954" "116.1" "98.3" "105.6" "116.5" "118.9" "109.5" "101.2" "118.4" "95.1" "110.7" "" "" "" "" "" "" "" "" "" "" "93.2" "71.0" "83.9" "78.1" "82.2" "82.2" "70.8" "86.5" "95.1" "90.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-240902922766624585" "False" "Medium" "IsMasterProtein" "Q8N5D0" "WD and tetratricopeptide repeats protein 1 OS=Homo sapiens OX=9606 GN=WDTC1 PE=1 SV=2" "0.025" "False" "1.707" "1" "1" "1" "1" "677" "75.9" "7.27" "2.88" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "23038" "ENSG00000142784" "WDTC1" "D3DPL5; hsa:23038; Q5SSC5; Q8N5D0; Q9NV87; Q9UPW4" "Neddylation" "" "1" "0" "1.169" "1.231" "1.158" "1.160" "1.097" "1.072" "1.139" "1.193" "1.124" "177.8" "207.9" "218.9" "205.9" "206.2" "195.0" "190.6" "202.6" "212.1" "199.9" "" "" "" "" "" "" "" "" "" "" "142.8" "150.0" "173.9" "138.0" "142.6" "146.3" "133.5" "147.9" "212.1" "162.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8369123714013872102" "False" "Medium" "IsMasterProtein" "Q07065" "Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2" "0.025" "False" "1.707" "1" "1" "1" "1" "602" "66.0" "5.92" "2.30" "1" "" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "10970" "ENSG00000136026" "CKAP4" "hsa:10970; Q07065; Q504S5; Q53ES6" "Neutrophil degranulation; RND2 GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND3 GTPase cycle; Surfactant metabolism" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-448736336253279631" "False" "Medium" "IsMasterProtein" "Q9Y2H0" "Disks large-associated protein 4 OS=Homo sapiens OX=9606 GN=DLGAP4 PE=1 SV=3" "0.025" "False" "1.706" "1" "1" "1" "1" "992" "107.9" "7.08" "2.66" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf03359" "22839" "ENSG00000080845" "DLGAP4" "E1P5T5; hsa:22839; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; Q9Y2H0" "Neurexins and neuroligins" "" "1" "0" "0.976" "0.990" "0.910" "0.772" "0.998" "0.959" "0.882" "0.911" "1.128" "85.6" "83.5" "84.7" "77.9" "66.1" "85.4" "82.1" "75.5" "78.0" "96.5" "" "" "" "" "" "" "" "" "" "" "68.8" "60.3" "67.3" "52.2" "45.7" "64.1" "57.5" "55.2" "78.0" "78.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482571623851624299" "False" "Medium" "IsMasterProtein" "Q7Z6M3" "Allergin-1 OS=Homo sapiens OX=9606 GN=MILR1 PE=1 SV=2" "0.025" "False" "1.704" "3" "1" "1" "1" "343" "38.7" "7.77" "2.91" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13895, Pf17736" "284021" "ENSG00000271605" "MILR1" "A1L458; B4DUS1; B7ZM50; B9EGN0; D6RUW6; D6RUW8; hsa:284021; Q7Z6M3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225862634974144158" "False" "Medium" "IsMasterProtein" "Q8N392" "Rho GTPase-activating protein 18 OS=Homo sapiens OX=9606 GN=ARHGAP18 PE=1 SV=3" "0.025" "False" "1.704" "2" "1" "1" "1" "663" "74.9" "6.44" "0.00" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "93663" "ENSG00000146376" "ARHGAP18" "E1P575; hsa:93663; Q58EZ3; Q6P679; Q6PJD7; Q8N392; Q96S64" "RHOC GTPase cycle; RHOA GTPase cycle" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7340986186018177511" "False" "Medium" "IsMasterProtein" "P05496" "ATP synthase F(0) complex subunit C1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MC1 PE=1 SV=2" "0.025" "False" "1.703" "5" "1" "1" "1" "136" "14.3" "9.74" "2.70" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00137" "516" "ENSG00000159199" "ATP5MC1" "hsa:516; P05496" "Mitochondrial protein import; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6210864852158670785" "False" "Medium" "IsMasterProtein" "Q9H8H2" "ATP-dependent DNA helicase DDX31 OS=Homo sapiens OX=9606 GN=DDX31 PE=1 SV=2" "0.026" "False" "1.696" "1" "1" "1" "1" "851" "94.0" "9.99" "2.12" "1" "other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "64794" "ENSG00000125485" "DDX31" "hsa:64794; Q5K6N2; Q5K6N3; Q5K6N4; Q5VZJ4; Q5VZJ9; Q96E91; Q96NY2; Q96SX5; Q9H5K6; Q9H8H2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "334815564542611035" "False" "Medium" "IsMasterProtein" "Q9BTF0" "THUMP domain-containing protein 2 OS=Homo sapiens OX=9606 GN=THUMPD2 PE=1 SV=2" "0.026" "False" "1.694" "2" "1" "1" "1" "503" "56.4" "7.81" "2.38" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "80745" "ENSG00000138050" "THUMPD2" "A8K7I7; hsa:80745; Q53TT8; Q53TV0; Q9BTF0" "" "" "0" "0" "0.835" "1.036" "1.192" "1.027" "1.138" "0.931" "1.082" "1.036" "0.988" "18.9" "15.8" "19.6" "22.6" "19.4" "21.5" "17.6" "20.5" "19.6" "18.7" "" "" "" "" "" "" "" "" "" "" "15.2" "11.4" "15.6" "15.1" "13.4" "16.2" "12.3" "15.0" "19.6" "15.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3558140715787164173" "False" "Medium" "IsMasterProtein" "Q9Y375" "Complex I intermediate-associated protein 30, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF1 PE=1 SV=2" "0.026" "False" "1.687" "3" "1" "1" "1" "327" "37.7" "7.64" "1.98" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf08547" "51103" "ENSG00000137806" "NDUFAF1" "hsa:51103; Q9BVZ5; Q9Y375" "Complex I biogenesis" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3610451847874307910" "False" "Medium" "IsMasterProtein" "A6NEE1" "Pleckstrin homology domain-containing family D member 1 OS=Homo sapiens OX=9606 GN=PLEKHD1 PE=1 SV=3" "0.026" "False" "1.686" "1" "1" "1" "1" "506" "59.2" "6.44" "2.57" "1" "" "" "" "Pf00169" "400224" "ENSG00000175985" "PLEKHD1" "A6NEE1; B9EJC2; hsa:400224" "" "" "0" "0" "0.967" "0.845" "1.001" "0.892" "1.165" "0.935" "1.011" "0.849" "0.949" "80.3" "77.6" "67.8" "80.4" "71.6" "93.5" "75.0" "81.2" "68.2" "76.2" "" "" "" "" "" "" "" "" "" "" "64.5" "56.0" "53.9" "53.9" "49.5" "70.2" "52.5" "59.3" "68.2" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1802642593183105004" "False" "Medium" "IsMasterProtein" "Q9UPA5" "Protein bassoon OS=Homo sapiens OX=9606 GN=BSN PE=1 SV=4" "0.026" "False" "1.679" "0" "1" "1" "1" "3926" "416.2" "7.55" "2.81" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05715" "8927" "ENSG00000164061" "BSN" "hsa:8927; O43161; Q7LGH3; Q9UPA5" "Sensory processing of sound by inner hair cells of the cochlea" "Cell lineage map for neuronal differentiation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7572022130176331113" "False" "Medium" "IsMasterProtein" "Q9H840" "Gem-associated protein 7 OS=Homo sapiens OX=9606 GN=GEMIN7 PE=1 SV=1" "0.026" "False" "1.679" "5" "1" "1" "1" "131" "14.5" "7.40" "2.84" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf11095" "79760" "ENSG00000142252" "GEMIN7" "hsa:79760; Q6IA34; Q9H840" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2959311852295820305" "False" "Medium" "IsMasterProtein" "Q6TFL3" "Coiled-coil domain-containing protein 171 OS=Homo sapiens OX=9606 GN=CCDC171 PE=1 SV=1" "0.026" "False" "1.677" "1" "1" "2" "1" "1326" "152.7" "6.81" "2.35" "1" "" "" "" "" "203238" "ENSG00000164989" "CCDC171" "B7ZM22; Q5SU58; Q6P1W1; Q6TFL3; Q6ZR13; Q8N1Z4; Q8N8L3; Q8TBR2" "" "" "0" "0" "1.068" "0.951" "1.287" "1.067" "1.126" "1.140" "1.211" "1.135" "1.119" "34.7" "37.0" "33.0" "44.6" "37.0" "39.1" "39.5" "42.0" "39.4" "38.8" "" "" "" "" "" "" "" "" "" "" "27.8" "26.7" "26.2" "29.9" "25.6" "29.3" "27.7" "30.7" "39.4" "31.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7076212038765232147" "False" "Medium" "IsMasterProtein" "Q96RR1" "Twinkle mtDNA helicase OS=Homo sapiens OX=9606 GN=TWNK PE=1 SV=1" "0.027" "False" "1.670" "3" "1" "1" "1" "684" "77.1" "8.98" "0.00" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf13481" "56652" "ENSG00000107815" "TWNK" "B2CQL2; hsa:56652; Q6MZX2; Q6PJP5; Q96RR0; Q96RR1" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "Primary ovarian insufficiency" "3" "0" "0.931" "1.325" "1.397" "1.234" "1.147" "0.908" "1.036" "1.207" "1.241" "13.4" "12.4" "17.7" "18.7" "16.5" "15.3" "12.1" "13.8" "16.1" "16.6" "" "" "" "" "" "" "" "" "" "" "10.7" "9.0" "14.1" "12.5" "11.4" "11.5" "8.5" "10.1" "16.1" "13.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5120026271963248451" "False" "Medium" "IsMasterProtein" "Q460N3" "Protein mono-ADP-ribosyltransferase PARP15 OS=Homo sapiens OX=9606 GN=PARP15 PE=1 SV=2" "0.027" "False" "1.665" "2" "1" "1" "1" "678" "74.5" "8.82" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00644, Pf01661" "165631" "ENSG00000173200" "PARP15" "hsa:165631; J3KR47; Q460N3; Q8N1K3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2658794876208962167" "False" "Medium" "IsMasterProtein" "Q9Y2D9" "Zinc finger protein 652 OS=Homo sapiens OX=9606 GN=ZNF652 PE=1 SV=3" "0.027" "False" "1.655" "1" "1" "1" "1" "606" "69.7" "8.65" "2.69" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "22834" "ENSG00000198740" "ZNF652" "A4QPD9; hsa:22834; Q5H9Q0; Q9Y2D9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4670744058278942272" "False" "Medium" "IsMasterProtein" "Q9UN74" "Protocadherin alpha-4 OS=Homo sapiens OX=9606 GN=PCDHA4 PE=1 SV=1" "0.027" "False" "1.654" "1" "1" "1" "1" "947" "102.2" "5.08" "2.60" "1" "cell adhesion;developmental processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974" "56144" "ENSG00000204967; ENSG00000291652" "PCDHA4" "hsa:56144; O75285; Q2M253; Q9UN74" "" "GDNF signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8504895740421257345" "False" "Medium" "IsMasterProtein" "Q9Y4W2" "Ribosomal biogenesis protein LAS1L OS=Homo sapiens OX=9606 GN=LAS1L PE=1 SV=2" "0.027" "False" "1.653" "1" "1" "1" "1" "734" "83.0" "4.73" "1.72" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04031" "81887" "ENSG00000001497" "LAS1L" "A9X410; hsa:81887; Q5JXQ0; Q8TEN5; Q9H9V5; Q9Y4W2" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5949318794217667053" "False" "Medium" "IsMasterProtein" "Q6Q759" "Sperm-associated antigen 17 OS=Homo sapiens OX=9606 GN=SPAG17 PE=1 SV=1" "0.028" "False" "1.646" "0" "1" "2" "1" "2223" "251.6" "6.24" "5.79" "1" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytoskeleton;ER/Golgi;other cell component" "" "Pf14874" "200162" "ENSG00000155761" "SPAG17" "Q6Q759; Q8NAZ1; Q9NT21" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4753996086079646907" "False" "Medium" "IsMasterProtein" "Q6XPR3" "Repetin OS=Homo sapiens OX=9606 GN=RPTN PE=1 SV=1" "0.028" "False" "1.645" "1" "1" "1" "1" "784" "90.7" "6.92" "0.00" "1" "" "non-structural extracellular;plasma membrane;cytosol" "other molecular function" "Pf01023" "126638" "ENSG00000215853" "RPTN" "B7ZBZ3; hsa:126638; Q6XPR3" "Formation of the cornified envelope" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8320420744586431417" "False" "Medium" "IsMasterProtein" "Q5JV73" "FERM and PDZ domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FRMPD3 PE=1 SV=3" "0.028" "False" "1.643" "1" "1" "1" "1" "1777" "195.5" "8.25" "2.89" "1" "" "plasma membrane;other membranes;cytoskeleton" "" "Pf00373, Pf00595, Pf21477" "" "ENSG00000147234" "FRMPD3" "A0A804HKI5; hsa:84443; Q5JV73; Q96JK8" "Neutrophil degranulation" "" "1" "0" "1.007" "0.980" "0.928" "0.893" "0.918" "0.937" "0.959" "0.914" "0.937" "126.8" "127.7" "124.3" "117.7" "113.3" "116.4" "118.8" "121.6" "116.0" "118.8" "" "" "" "" "" "" "" "" "" "" "101.9" "92.1" "98.7" "78.8" "78.3" "87.3" "83.2" "88.8" "116.0" "96.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388597074234396696" "False" "Medium" "IsMasterProtein" "P04083" "Annexin A1 OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=2" "0.028" "False" "1.641" "2" "1" "1" "1" "346" "38.7" "7.02" "2.63" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00191" "301" "ENSG00000135046" "ANXA1" "B5BU38; hsa:301; P04083" "G alpha (q) signalling events; G alpha (i) signalling events; Interleukin-4 and Interleukin-13 signaling; Smooth Muscle Contraction; Formyl peptide receptors bind formyl peptides and many other ligands" "Spinal cord injury; VEGFA-VEGFR2 signaling; Prostaglandin synthesis and regulation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1497740122337544392" "False" "Medium" "IsMasterProtein" "Q8N3C7" "CAP-Gly domain-containing linker protein 4 OS=Homo sapiens OX=9606 GN=CLIP4 PE=1 SV=1" "0.029" "False" "1.629" "1" "1" "1" "1" "705" "76.3" "8.70" "1.61" "1" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf12796" "79745" "ENSG00000115295" "CLIP4" "A0AV10; B2RMQ3; B7Z7N8; hsa:79745; Q7Z4U3; Q8N3C7; Q96BR7; Q96MA5; Q9H7C0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "837370257864581378" "False" "Medium" "IsMasterProtein" "Q01415" "N-acetylgalactosamine kinase OS=Homo sapiens OX=9606 GN=GALK2 PE=1 SV=1" "0.029" "False" "1.619" "2" "1" "1" "1" "458" "50.3" "6.61" "2.08" "1" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2585" "ENSG00000156958" "GALK2" "hsa:2585; Q01415; Q7Z4Q4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2564632356119292656" "False" "Medium" "IsMasterProtein" "P04843" "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1" "0.029" "False" "1.615" "1" "1" "1" "1" "607" "68.5" "6.38" "2.03" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf04597" "6184" "ENSG00000163902" "RPN1" "B2R5Z0; D3DNB6; hsa:6184; P04843; Q68DT1" "SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein" "Proteasome degradation; N-glycan biosynthesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830044748160233517" "False" "Medium" "IsMasterProtein" "Q7RTU9" "Stereocilin OS=Homo sapiens OX=9606 GN=STRC PE=2 SV=1" "0.029" "False" "1.612" "1" "1" "1" "1" "1775" "192.8" "5.41" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf21058" "161497" "ENSG00000242866" "STRC" "hsa:161497; Q7RTU9" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "1.786" "0.925" "2.027" "1.558" "1.212" "2.009" "1.330" "1.058" "1.111" "19.1" "34.0" "17.6" "38.6" "29.7" "23.1" "38.3" "25.3" "20.2" "21.2" "" "" "" "" "" "" "" "" "" "" "15.3" "24.5" "14.0" "25.9" "20.5" "17.3" "26.8" "18.5" "20.2" "17.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-879380199029803556" "False" "Medium" "IsMasterProtein" "Q9ULV0" "Unconventional myosin-Vb OS=Homo sapiens OX=9606 GN=MYO5B PE=1 SV=3" "0.029" "False" "1.609" "1" "1" "1" "1" "1848" "213.5" "7.20" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf01843" "4645" "ENSG00000167306" "MYO5B" "B0I1R3; hsa:4645; Q0P656; Q9H6Y6; Q9ULV0" "Vasopressin regulates renal water homeostasis via Aquaporins" "Alstrom syndrome" "2" "0" "0.995" "0.886" "1.032" "1.038" "0.955" "1.344" "0.925" "0.816" "1.224" "90.3" "89.8" "79.9" "93.1" "93.7" "86.2" "121.3" "83.5" "73.6" "110.5" "" "" "" "" "" "" "" "" "" "" "72.5" "64.8" "63.5" "62.4" "64.8" "64.7" "84.9" "61.0" "73.6" "89.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-501773806852137610" "False" "Medium" "IsMasterProtein" "Q96PN7" "Transcriptional-regulating factor 1 OS=Homo sapiens OX=9606 GN=TRERF1 PE=1 SV=1" "0.029" "False" "1.607" "1" "1" "1" "1" "1200" "132.2" "6.74" "2.28" "1" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01448, Pf13912" "55809" "ENSG00000124496" "TRERF1" "hsa:55809; Q05GC6; Q7Z6T2; Q7Z6T3; Q96PN7; Q9NQ72; Q9NQ73; Q9NUN9" "" "Mesodermal commitment pathway" "1" "0" "0.912" "0.880" "0.964" "1.051" "0.854" "0.900" "0.977" "1.012" "0.871" "194.3" "177.2" "171.1" "187.2" "204.2" "166.0" "174.8" "189.9" "196.7" "169.3" "" "" "" "" "" "" "" "" "" "" "156.1" "127.8" "135.9" "125.4" "141.3" "124.5" "122.4" "138.7" "196.7" "137.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-675994794454034508" "False" "Medium" "IsMasterProtein" "Q15744" "CCAAT/enhancer-binding protein epsilon OS=Homo sapiens OX=9606 GN=CEBPE PE=1 SV=2" "0.029" "False" "1.606" "4" "1" "1" "1" "281" "30.6" "8.98" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1053" "ENSG00000092067" "CEBPE" "hsa:1053; Q15744; Q15745; Q8IYI2; Q99803" "Transcriptional regulation of granulopoiesis" "Acute myeloid leukemia" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9097228203525967299" "False" "Medium" "IsMasterProtein" "Q8TER0" "Sushi, nidogen and EGF-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNED1 PE=1 SV=2" "0.029" "False" "1.605" "1" "1" "1" "1" "1413" "152.1" "6.98" "2.54" "1" "cell adhesion" "non-structural extracellular;extracellular matrix" "signal transduction activity or receptor binding;other molecular function" "Pf00008, Pf00041, Pf06119, Pf12661" "25992" "ENSG00000162804" "SNED1" "B5MDC3; B7WNK6; B7WPM0; hsa:25992; Q336F4; Q336F5; Q8N369; Q8TEP7; Q8TER0" "" "2q37 copy number variation syndrome" "1" "0" "0.934" "0.849" "0.931" "1.049" "1.178" "1.033" "0.978" "1.055" "1.003" "182.2" "170.2" "154.8" "169.7" "191.0" "214.7" "188.3" "178.1" "192.2" "182.7" "" "" "" "" "" "" "" "" "" "" "146.3" "122.8" "122.9" "113.7" "132.1" "161.1" "131.8" "130.1" "192.2" "148.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6869993653932591832" "False" "Medium" "IsMasterProtein" "P51449" "Nuclear receptor ROR-gamma OS=Homo sapiens OX=9606 GN=RORC PE=1 SV=2" "0.029" "False" "1.603" "2" "1" "1" "1" "518" "58.2" "8.54" "0.00" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "6097" "ENSG00000143365" "RORC" "hsa:6097; P51449; Q5SZR9; Q8N5V7; Q8NCY8" "Nuclear Receptor transcription pathway; Interleukin-4 and Interleukin-13 signaling" "Nuclear receptors; 22q11.2 copy number variation syndrome; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-26 signaling pathways" "7" "0" "0.697" "0.903" "0.840" "0.946" "0.974" "0.892" "0.741" "0.909" "1.050" "65.9" "46.0" "59.5" "55.4" "62.3" "64.2" "58.8" "48.8" "59.9" "69.1" "" "" "" "" "" "" "" "" "" "" "52.9" "33.2" "47.3" "37.1" "43.1" "48.1" "41.1" "35.6" "59.9" "56.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7270530672924286629" "False" "Medium" "IsMasterProtein" "Q86TM6" "E3 ubiquitin-protein ligase synoviolin OS=Homo sapiens OX=9606 GN=SYVN1 PE=1 SV=2" "0.029" "False" "1.602" "1" "1" "1" "1" "617" "67.6" "6.95" "2.18" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13639" "84447" "ENSG00000162298" "SYVN1" "hsa:84447; Q86TM6; Q8N3K3; Q8N6E8; Q96JL5; Q96PK3" "Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537726358648831558" "False" "Medium" "IsMasterProtein" "Q5U649" "Uncharacterized protein C12orf60 OS=Homo sapiens OX=9606 GN=C12orf60 PE=1 SV=2" "0.029" "False" "1.602" "4" "1" "1" "1" "245" "27.6" "7.96" "2.33" "1" "" "" "" "Pf15047" "144608" "ENSG00000182993" "C12orf60" "A8K1M7; hsa:144608; Q5U649; Q5XKK8; Q8IXY2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8867996448924802282" "False" "Medium" "IsMasterProtein" "O43255" "E3 ubiquitin-protein ligase SIAH2 OS=Homo sapiens OX=9606 GN=SIAH2 PE=1 SV=1" "0.029" "False" "1.593" "2" "1" "1" "1" "324" "34.6" "7.12" "0.00" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03145, Pf21361, Pf21362" "6478" "ENSG00000181788" "SIAH2" "hsa:6478; O43255; O43270" "Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; Ub-specific processing proteases; Netrin-1 signaling" "Parkin-ubiquitin proteasomal system pathway; Endoderm differentiation; VEGFA-VEGFR2 signaling" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7445573923015050179" "False" "Medium" "IsMasterProtein" "Q9BYC8" "Large ribosomal subunit protein bL32m OS=Homo sapiens OX=9606 GN=MRPL32 PE=1 SV=1" "0.029" "False" "1.591" "4" "1" "1" "1" "188" "21.4" "9.73" "2.81" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01783" "64983" "ENSG00000106591" "MRPL32" "hsa:64983; Q96Q68; Q9BYC8; Q9P098" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1253491667474382087" "False" "Medium" "IsMasterProtein" "Q9Y4D1" "Disheveled-associated activator of morphogenesis 1 OS=Homo sapiens OX=9606 GN=DAAM1 PE=1 SV=2" "0.030" "False" "1.586" "1" "1" "1" "1" "1078" "123.4" "7.23" "2.98" "1" "cell-cell signaling;cell organization and biogenesis;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "23002" "ENSG00000100592" "DAAM1" "hsa:23002; Q86U34; Q8N1Z8; Q8TB39; Q9Y4D1" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHO GTPases Activate Formins; PCP/CE pathway" "Physico-chemical features and toxicity-associated pathways; Wnt signaling" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8286530119888385384" "False" "Medium" "IsMasterProtein" "P36969" "Phospholipid hydroperoxide glutathione peroxidase GPX4 OS=Homo sapiens OX=9606 GN=GPX4 PE=1 SV=3" "0.030" "False" "1.583" "5" "1" "1" "1" "197" "22.2" "8.37" "2.73" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00255" "2879" "ENSG00000167468" "GPX4" "hsa:2879; O43381; P36969; Q6PJ59; Q9UPK2" "Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485661638841027145" "False" "Medium" "IsMasterProtein" "P24043" "Laminin subunit alpha-2 OS=Homo sapiens OX=9606 GN=LAMA2 PE=1 SV=4" "0.030" "False" "1.577" "0" "1" "2" "1" "3122" "343.7" "6.40" "4.21" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00052, Pf00053, Pf00054, Pf00055, Pf02210, Pf06008, Pf06009" "3908" "ENSG00000196569" "LAMA2" "P24043; Q14736; Q5VUM2; Q93022" "ECM proteoglycans; Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Acute viral myocarditis; Small cell lung cancer; Pleural mesothelioma; Orexin receptor pathway" "14" "0" "0.984" "1.055" "0.928" "0.894" "1.025" "0.876" "0.984" "0.983" "1.053" "172.9" "170.2" "182.5" "160.5" "154.6" "177.2" "151.5" "170.2" "170.0" "182.0" "" "" "" "" "" "" "" "" "" "" "138.9" "122.8" "145.0" "107.5" "106.9" "133.0" "106.1" "124.3" "170.0" "148.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8754734411753965302" "False" "Medium" "IsMasterProtein" "P19823" "Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2" "0.030" "False" "1.573" "1" "1" "1" "1" "946" "106.4" "6.86" "2.90" "1" "other metabolic processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00092, Pf06668, Pf08487" "3698" "ENSG00000151655" "ITIH2" "hsa:3698; P19823; Q14659; Q15484; Q5T986" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6384672400329607231" "False" "Medium" "IsMasterProtein" "Q64LD2" "WD repeat-containing protein 25 OS=Homo sapiens OX=9606 GN=WDR25 PE=1 SV=3" "0.031" "False" "1.571" "1" "1" "1" "1" "544" "60.1" "9.00" "2.04" "1" "" "" "" "Pf00400" "79446" "ENSG00000176473" "WDR25" "A8K7E5; hsa:79446; Q64LD2; Q6NVV6; Q86TQ4; Q9BTK5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5979521826896311774" "False" "Medium" "IsMasterProtein" "Q9H6L4" "Armadillo repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=ARMC7 PE=1 SV=1" "0.033" "False" "1.560" "4" "1" "1" "1" "198" "21.9" "6.09" "2.32" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00514" "79637" "ENSG00000125449" "ARMC7" "B4DVA4; hsa:79637; Q9H6L4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043221391200171951" "False" "Medium" "IsMasterProtein" "Q12923" "Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens OX=9606 GN=PTPN13 PE=1 SV=2" "0.033" "False" "1.557" "0" "1" "1" "1" "2485" "276.7" "6.42" "2.39" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102, Pf00373, Pf00595, Pf09379, Pf09380, Pf16599" "5783" "ENSG00000163629" "PTPN13" "B2RTR0; hsa:5783; Q12923; Q15159; Q15263; Q15264; Q15265; Q15674; Q16826; Q8IWH7; Q9NYN9; Q9UDA8" "Synthesis of PIPs at the plasma membrane; RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-37 signaling" "Apoptosis modulation and signaling; Ectoderm differentiation; Ectoderm differentiation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1802917873178363398" "False" "Medium" "IsMasterProtein" "Q96P56" "Cation channel sperm-associated protein 2 OS=Homo sapiens OX=9606 GN=CATSPER2 PE=1 SV=2" "0.033" "False" "1.554" "3" "1" "1" "1" "530" "62.0" "7.30" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton" "transporter activity" "Pf00520" "117155" "ENSG00000166762" "CATSPER2" "hsa:117155; Q8NHT9; Q96P54; Q96P55; Q96P56" "Sperm Motility And Taxes" "" "1" "0" "1.385" "1.043" "1.427" "1.805" "1.485" "1.515" "1.043" "1.191" "1.253" "24.9" "34.5" "25.9" "35.5" "44.9" "36.9" "37.7" "25.9" "29.6" "31.2" "" "" "" "" "" "" "" "" "" "" "20.0" "24.9" "20.6" "23.8" "31.0" "27.7" "26.4" "18.9" "29.6" "25.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7897691878290275966" "False" "Medium" "IsMasterProtein" "Q9Y680" "Peptidyl-prolyl cis-trans isomerase FKBP7 OS=Homo sapiens OX=9606 GN=FKBP7 PE=1 SV=2" "0.033" "False" "1.551" "5" "1" "1" "1" "222" "25.8" "6.32" "2.18" "1" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf00254, Pf13202" "51661" "ENSG00000079150" "FKBP7" "hsa:51661; Q4ZG70; Q6V3B2; Q86U65; Q96DA4; Q9Y680; Q9Y6B0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470537921174600195" "False" "Medium" "IsMasterProtein" "Q9NZM1" "Myoferlin OS=Homo sapiens OX=9606 GN=MYOF PE=1 SV=1" "0.034" "False" "1.545" "0" "1" "1" "1" "2061" "234.6" "6.18" "2.03" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00168, Pf08150, Pf08151, Pf08165, Pf16165" "26509" "ENSG00000138119" "MYOF" "B3KQN5; hsa:26509; Q5VWW2; Q5VWW3; Q5VWW4; Q5VWW5; Q7Z642; Q8IWH0; Q9HBU3; Q9NZM0; Q9NZM1; Q9ULL3; Q9Y4U4" "" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Hepatitis C and hepatocellular carcinoma" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "935705506060532462" "False" "Medium" "IsMasterProtein" "A0A0U1RRE5" "Negative regulator of P-body association OS=Homo sapiens OX=9606 GN=NBDY PE=1 SV=1" "0.034" "False" "1.543" "13" "1" "2" "1" "68" "7.0" "9.42" "2.90" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "" "" "550643" "ENSG00000204272" "NBDY" "A0A0U1RRE5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-659218503775552342" "False" "Medium" "IsMasterProtein" "Q9UBU7" "Protein DBF4 homolog A OS=Homo sapiens OX=9606 GN=DBF4 PE=1 SV=1" "0.034" "False" "1.539" "1" "1" "1" "1" "674" "76.8" "7.90" "1.79" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07535" "10926" "ENSG00000006634" "DBF4" "A4D1D8; A8K954; hsa:10926; O75226; Q75MS6; Q75N01; Q9UBU7; Q9Y2M6" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex" "Cell cycle; DNA replication" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769087556665891581" "False" "Medium" "IsMasterProtein" "P35556" "Fibrillin-2 OS=Homo sapiens OX=9606 GN=FBN2 PE=1 SV=3" "0.034" "False" "1.536" "0" "1" "3" "1" "2912" "314.6" "4.86" "0.00" "1" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00683, Pf07645, Pf12661, Pf12662, Pf12947, Pf18193, Pf21364" "2201" "ENSG00000138829" "FBN2" "B4DU01; hsa:2201; P35556; Q59ES6" "Degradation of the extracellular matrix; Molecules associated with elastic fibres" "Hypothesized pathways in pathogenesis of cardiovascular disease" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8228152586498192209" "False" "Medium" "IsMasterProtein" "Q9P218" "Collagen alpha-1(XX) chain OS=Homo sapiens OX=9606 GN=COL20A1 PE=1 SV=4" "0.034" "False" "1.535" "1" "1" "1" "1" "1284" "135.7" "8.06" "0.00" "1" "" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "" "Pf00041, Pf00092, Pf01391" "57642" "ENSG00000101203" "COL20A1" "hsa:57642; Q4VXQ4; Q6PI59; Q8WUT2; Q96CY9; Q9BQU6; Q9BQU7; Q9P218" "Collagen chain trimerization" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "1" "" "-2212959382001906818" "False" "Medium" "IsMasterProtein" "A6NCS6" "Uncharacterized protein C2orf72 OS=Homo sapiens OX=9606 GN=C2orf72 PE=1 SV=2" "0.034" "False" "1.535" "3" "1" "1" "1" "295" "30.5" "8.34" "3.12" "1" "" "" "" "Pf15443" "257407" "ENSG00000204128" "C2orf72" "A6NCS6; hsa:257407" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "780568065992678801" "False" "Medium" "IsMasterProtein" "Q9ULN7" "Paraneoplastic antigen-like protein 8B OS=Homo sapiens OX=9606 GN=PNMA8B PE=1 SV=4" "0.034" "False" "1.533" "2" "1" "1" "1" "635" "68.6" "5.45" "2.20" "1" "" "" "" "Pf20846" "57469" "ENSG00000204851" "PNMA8B" "C9JGD5; hsa:57469; M0R374; Q08E79; Q0D2F9; Q6ZVD1; Q9ULN7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6462604528965410945" "False" "Medium" "IsMasterProtein" "O15392" "Baculoviral IAP repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=BIRC5 PE=1 SV=3" "0.034" "False" "1.533" "5" "1" "1" "1" "142" "16.4" "5.90" "3.21" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00653" "332" "ENSG00000089685" "BIRC5" "A2SUH6; B2R4R1; hsa:332; O15392; Q2I3N8; Q4VGX0; Q53F61; Q5MGC6; Q6FHL2; Q75SP2; Q9P2W8" "Separation of Sister Chromatids; Neddylation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "Apoptosis modulation and signaling; Interleukin-11 signaling pathway; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Extracellular vesicles in the crosstalk of cardiac cells; Gastrin signaling pathway; Hepatitis B infection; HDAC6 interactions in the central nervous system" "25" "0" "1.006" "0.967" "1.036" "1.057" "1.091" "0.676" "0.680" "0.701" "0.893" "320.4" "322.2" "309.9" "331.9" "338.7" "349.7" "216.5" "217.9" "224.7" "286.2" "" "" "" "" "" "" "" "" "" "" "257.4" "232.5" "246.2" "222.4" "234.3" "262.4" "151.6" "159.1" "224.7" "232.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5353080058123146461" "False" "Medium" "IsMasterProtein" "P23229" "Integrin alpha-6 OS=Homo sapiens OX=9606 GN=ITGA6 PE=1 SV=5" "0.035" "False" "1.532" "1" "1" "1" "1" "1130" "126.5" "6.61" "2.46" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01839, Pf08441, Pf20805, Pf20806" "3655" "ENSG00000091409" "ITGA6" "B2RMU9; B4DG69; B4DKB8; C4AM96; G5E9H1; hsa:3655; P23229; Q08443; Q0MRC7; Q14646; Q16508; Q53RX7; Q59HB7; Q86VL6; Q9UCT1; Q9UN03" "Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Syndecan interactions; Laminin interactions; Basigin interactions; Type I hemidesmosome assembly" "Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Regulation of apoptosis by parathyroid hormone-related protein; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Small cell lung cancer; Pleural mesothelioma; GDNF signaling; 11p11.2 copy number variation syndrome ; Cell lineage map for neuronal differentiation" "20" "0" "1.087" "1.080" "1.171" "1.132" "0.974" "0.977" "1.081" "1.146" "1.187" "97.5" "106.0" "105.3" "114.2" "110.4" "95.0" "95.3" "105.4" "111.8" "115.7" "" "" "" "" "" "" "" "" "" "" "78.3" "76.5" "83.7" "76.5" "76.4" "71.3" "66.7" "77.0" "111.8" "94.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5231348183886485815" "False" "Medium" "IsMasterProtein" "Q6PRD1" "Probable G-protein coupled receptor 179 OS=Homo sapiens OX=9606 GN=GPR179 PE=1 SV=2" "0.035" "False" "1.531" "1" "1" "1" "1" "2367" "257.2" "5.71" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00003" "440435" "ENSG00000276469" "GPR179" "hsa:440435; Q6PRD1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3916053550852325931" "False" "Medium" "IsMasterProtein" "Q9UBX7" "Kallikrein-11 OS=Homo sapiens OX=9606 GN=KLK11 PE=1 SV=2" "0.035" "False" "1.531" "4" "1" "1" "1" "282" "31.0" "8.94" "2.99" "1" "protein metabolism" "ER/Golgi;other cell component" "other molecular function" "Pf00089" "11012" "ENSG00000167757" "KLK11" "hsa:11012; O75837; Q0WXX5; Q8IXD7; Q9NS65; Q9UBX7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1090044883093451685" "False" "Medium" "IsMasterProtein" "Q6PGQ7" "Protein aurora borealis OS=Homo sapiens OX=9606 GN=BORA PE=1 SV=2" "0.035" "False" "1.530" "2" "1" "1" "1" "559" "61.2" "4.94" "0.00" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15280" "79866" "ENSG00000136122" "BORA" "B4DQ30; hsa:79866; Q5W0P3; Q5W0P4; Q6PGQ7; Q86YC6; Q96IW9; Q9H640" "Regulation of PLK1 Activity at G2/M Transition" "" "1" "0" "1.054" "0.789" "1.173" "0.714" "0.837" "0.591" "1.230" "1.109" "1.057" "16.1" "16.9" "12.7" "18.9" "11.5" "13.4" "9.5" "19.8" "17.8" "17.0" "" "" "" "" "" "" "" "" "" "" "12.9" "12.2" "10.1" "12.6" "7.9" "10.1" "6.7" "14.4" "17.8" "13.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5479152358026622907" "False" "Medium" "IsMasterProtein" "Q8WV74" "Mitochondrial coenzyme A diphosphatase NUDT8 OS=Homo sapiens OX=9606 GN=NUDT8 PE=1 SV=2" "0.035" "False" "1.528" "3" "1" "1" "1" "236" "25.4" "8.41" "2.83" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00293" "254552" "ENSG00000167799" "NUDT8" "hsa:254552; Q6ZW59; Q8WV74" "Vitamin B5 (pantothenate) metabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5644554619979627576" "False" "Medium" "IsMasterProtein" "O75251" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3" "0.035" "False" "1.522" "4" "1" "1" "1" "213" "23.5" "9.99" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01058" "374291" "ENSG00000115286" "NDUFS7" "B3KRI2; hsa:374291; O75251; Q2T9H7; Q9BV17" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7800282682775508248" "False" "Medium" "IsMasterProtein" "Q9H819" "DnaJ homolog subfamily C member 18 OS=Homo sapiens OX=9606 GN=DNAJC18 PE=1 SV=1" "0.035" "False" "1.520" "2" "1" "1" "1" "358" "41.5" "7.37" "2.27" "1" "protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi" "other molecular function" "Pf00226, Pf09320" "202052" "ENSG00000170464" "DNAJC18" "hsa:202052; Q9H819" "" "" "0" "0" "0.850" "0.995" "0.858" "1.010" "0.864" "0.680" "0.981" "0.989" "1.178" "39.7" "33.7" "39.5" "34.1" "40.1" "34.3" "27.0" "38.9" "39.3" "46.7" "" "" "" "" "" "" "" "" "" "" "31.9" "24.3" "31.4" "22.8" "27.7" "25.7" "18.9" "28.4" "39.3" "38.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613446227669289232" "False" "Medium" "IsMasterProtein" "Q9H8K7" "ATPase PAAT OS=Homo sapiens OX=9606 GN=PAAT PE=1 SV=2" "0.035" "False" "1.520" "2" "1" "1" "1" "445" "49.2" "6.25" "2.75" "1" "" "mitochondrion;other cell component" "other molecular function" "Pf14958" "80007" "ENSG00000119965" "PAAT" "hsa:80007; Q0P6C6; Q8N597; Q9H8K7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516422207583123109" "False" "Medium" "IsMasterProtein" "Q9NUD5" "Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2" "0.036" "False" "1.516" "2" "1" "1" "1" "403" "43.5" "8.53" "2.44" "1" "stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "85364" "ENSG00000247315" "ZCCHC3" "hsa:85364; Q3B7J3; Q6NT79; Q9NUD5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4145658284942206379" "False" "Medium" "IsMasterProtein" "Q15904" "V-type proton ATPase subunit S1 OS=Homo sapiens OX=9606 GN=ATP6AP1 PE=1 SV=2" "0.036" "False" "1.510" "2" "1" "1" "1" "470" "52.0" "6.14" "2.85" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf05827, Pf20520" "537" "ENSG00000071553" "ATP6AP1" "A6ZKI4; Q15904; Q8NBT4; Q9H0C7" "RHOA GTPase cycle; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Hepatitis B infection; Oxidative phosphorylation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6203611519781264671" "False" "Medium" "IsMasterProtein" "Cont_P21578" "Yellow fluorescent protein OS=Aliivibrio fischeri OX=668 GN=luxY PE=1 SV=1" "0.036" "True" "1.509" "7" "1" "1" "1" "194" "22.2" "5.72" "0.00" "1" "other metabolic processes" "" "" "Pf00677" "" "" "luxY" "A0A2S7X4I9; P21578" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1179356982440791831" "False" "Medium" "IsMasterProtein" "Q6ZNW5" "GDP-D-glucose phosphorylase 1 OS=Homo sapiens OX=9606 GN=GDPGP1 PE=1 SV=2" "0.036" "False" "1.501" "2" "1" "1" "1" "385" "42.3" "6.47" "2.33" "1" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "" "390637" "ENSG00000183208" "GDPGP1" "hsa:390637; Q6ZNW5" "" "" "0" "0" "0.779" "0.832" "0.834" "0.901" "1.014" "0.849" "0.989" "0.968" "0.888" "98.4" "76.7" "81.9" "82.1" "88.6" "99.8" "83.5" "97.3" "95.2" "87.4" "" "" "" "" "" "" "" "" "" "" "79.0" "55.3" "65.1" "55.0" "61.3" "74.9" "58.5" "71.1" "95.2" "71.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6758032163322400998" "False" "Medium" "IsMasterProtein" "Q76G19" "PDZ domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PDZD4 PE=1 SV=1" "0.036" "False" "1.499" "2" "1" "1" "1" "769" "86.1" "6.13" "0.00" "1" "protein metabolism" "other cell component" "" "Pf00595" "57595" "ENSG00000067840" "PDZD4" "B3KXB1; B7ZKY3; hsa:57595; Q76G19; Q8NB75; Q9BUH9; Q9P284" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5953737465852294599" "False" "Medium" "IsMasterProtein" "O75493" "Carbonic anhydrase-related protein 11 OS=Homo sapiens OX=9606 GN=CA11 PE=1 SV=2" "0.036" "False" "1.499" "3" "1" "1" "1" "328" "36.2" "9.74" "2.14" "1" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00194" "770" "ENSG00000063180" "CA11" "hsa:770; O60596; O75493; Q6FHI1; Q9UEC4" "" "IL-18 signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583297496943735120" "False" "Medium" "IsMasterProtein" "Q5JTW2" "Centrosomal protein of 78 kDa OS=Homo sapiens OX=9606 GN=CEP78 PE=1 SV=1" "0.037" "False" "1.497" "2" "1" "1" "1" "689" "76.3" "8.18" "1.85" "1" "cell organization and biogenesis" "cytosol;cytoskeleton" "" "Pf13516" "84131" "ENSG00000148019" "CEP78" "A1A4S8; E9PHX5; hsa:84131; Q5BJE3; Q5JTW0; Q5JTW1; Q5JTW2; Q9H9N3" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Ciliopathies" "8" "0" "1.185" "0.788" "1.654" "1.474" "0.931" "1.511" "1.260" "1.195" "1.278" "54.1" "64.1" "42.6" "89.5" "79.7" "50.4" "81.8" "68.2" "64.6" "69.2" "" "" "" "" "" "" "" "" "" "" "43.5" "46.3" "33.9" "60.0" "55.1" "37.8" "57.2" "49.8" "64.6" "56.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4683122376706688572" "False" "Medium" "IsMasterProtein" "Q9BZF2" "Oxysterol-binding protein-related protein 7 OS=Homo sapiens OX=9606 GN=OSBPL7 PE=1 SV=1" "0.037" "False" "1.493" "1" "1" "1" "1" "842" "95.4" "8.05" "2.38" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "114881" "ENSG00000006025" "OSBPL7" "D3DTT6; hsa:114881; Q6PIV6; Q9BZF2" "Synthesis of bile acids and bile salts" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8458810131294421202" "False" "Medium" "IsMasterProtein" "Q96IK1" "Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens OX=9606 GN=BOD1 PE=1 SV=2" "0.037" "False" "1.490" "4" "1" "1" "1" "185" "19.2" "6.33" "2.59" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05205" "91272" "ENSG00000145919" "BOD1" "B4DXH8; hsa:91272; Q96IK1; Q9BTW1" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "1.232" "1.162" "1.271" "1.065" "0.972" "1.031" "1.052" "1.002" "1.075" "118.4" "145.9" "137.6" "150.5" "126.1" "115.1" "122.1" "124.6" "118.6" "127.3" "" "" "" "" "" "" "" "" "" "" "95.1" "105.3" "109.3" "100.8" "87.2" "86.3" "85.5" "91.0" "118.6" "103.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-31044771765994045" "False" "Medium" "IsMasterProtein" "Cont_Q6E0U4" "Dermokine OS=Homo sapiens OX=9606 GN=DMKN PE=1 SV=3" "0.037" "True" "1.489" "1" "1" "1" "1" "476" "47.1" "7.28" "1.98" "1" "cell organization and biogenesis" "non-structural extracellular" "" "" "93099" "ENSG00000161249" "DMKN" "A3EZ79; A3EZ80; A3EZ81; A3EZ82; A3EZ83; C9J4P6; C9J5N8; C9JAL3; hsa:93099; Q32W58; Q32W62; Q32W63; Q32W64; Q32W65; Q32W66; Q32W67; Q6E0U4; Q6E0U5; Q6UXC7; Q96EW8; Q9BSY6" "" "" "0" "0" "0.893" "0.698" "1.209" "0.946" "1.185" "1.161" "1.088" "1.075" "1.100" "113.7" "101.6" "79.4" "137.5" "107.5" "134.8" "132.0" "123.7" "122.2" "125.0" "" "" "" "" "" "" "" "" "" "" "91.3" "73.3" "63.1" "92.1" "74.4" "101.1" "92.4" "90.3" "122.2" "101.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6606403320182529666" "False" "Medium" "IsMasterProtein" "A0AVI2" "Fer-1-like protein 5 OS=Homo sapiens OX=9606 GN=FER1L5 PE=1 SV=3" "0.037" "False" "1.488" "0" "1" "1" "1" "2057" "237.8" "8.05" "2.36" "1" "other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00168, Pf08150, Pf08165, Pf16165" "90342" "ENSG00000249715" "FER1L5" "A0A096LNV2; A0AVI2; hsa:90342; Q17RH2; Q6ZU24" "" "2q11.2 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8616420449597169921" "False" "Medium" "IsMasterProtein" "Cont_P01017" "Angiotensinogen OS=Bos taurus OX=9913 GN=AGT PE=1 SV=2" "0.037" "True" "1.484" "3" "1" "1" "1" "476" "51.4" "6.96" "1.69" "1" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00079" "" "ENSBIXG00000023240; ENSBIXG00005031426; ENSBTAG00000012393" "AGT" "A0A3Q1LGY9; A0A4W2IQY5; P01017" "Peptide ligand-binding receptors; G alpha (q) signalling events; G alpha (i) signalling events; Metabolism of Angiotensinogen to Angiotensins" "ACE inhibitor pathway; Monoamine transport; IL-6 signaling pathway; Adipogenesis" "8" "0" "1.399" "0.936" "1.203" "1.165" "1.330" "1.192" "0.728" "1.290" "1.067" "46.7" "65.4" "43.7" "56.2" "54.4" "62.1" "55.7" "34.0" "60.2" "49.8" "" "" "" "" "" "" "" "" "" "" "37.5" "47.2" "34.7" "37.6" "37.6" "46.6" "39.0" "24.8" "60.2" "40.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5572152547917971737" "False" "Medium" "IsMasterProtein" "Q5T3J3" "Ligand-dependent nuclear receptor-interacting factor 1 OS=Homo sapiens OX=9606 GN=LRIF1 PE=1 SV=1" "0.038" "False" "1.479" "1" "1" "1" "1" "769" "84.5" "9.72" "2.22" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf15741" "55791" "ENSG00000121931" "LRIF1" "hsa:55791; Q5T3J3; Q86XS4; Q8N3B6; Q96HT4; Q9NUM5; Q9NV32" "" "" "0" "0" "1.094" "1.030" "1.370" "1.121" "1.108" "1.159" "0.964" "1.155" "1.192" "98.4" "107.7" "101.4" "134.9" "110.3" "109.0" "114.1" "94.9" "113.7" "117.3" "" "" "" "" "" "" "" "" "" "" "79.1" "77.7" "80.5" "90.4" "76.3" "81.8" "79.9" "69.3" "113.7" "95.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3850938661228975130" "False" "Medium" "IsMasterProtein" "Q9NQ55" "Suppressor of SWI4 1 homolog OS=Homo sapiens OX=9606 GN=PPAN PE=1 SV=1" "0.038" "False" "1.478" "1" "1" "1" "1" "473" "53.2" "10.13" "2.72" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04427" "56342; 692312" "ENSG00000130810" "PPAN" "C9J3F9; hsa:56342; hsa:692312; Q9BW97; Q9H170; Q9NQ55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5699619529489885522" "False" "Medium" "IsMasterProtein" "Q9Y250" "Leucine zipper putative tumor suppressor 1 OS=Homo sapiens OX=9606 GN=LZTS1 PE=1 SV=3" "0.038" "False" "1.473" "1" "1" "1" "1" "596" "66.6" "7.09" "2.42" "1" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf06818" "11178" "ENSG00000061337" "LZTS1" "D3DSQ6; hsa:11178; Q9Y250; Q9Y5V7; Q9Y5V8; Q9Y5V9; Q9Y5W0; Q9Y5W1; Q9Y5W2" "" "" "0" "0" "0.944" "1.281" "1.094" "1.053" "0.982" "1.033" "1.069" "1.327" "1.090" "54.9" "51.8" "70.3" "60.0" "57.8" "53.9" "56.7" "58.7" "72.9" "59.8" "" "" "" "" "" "" "" "" "" "" "44.1" "37.4" "55.9" "40.2" "40.0" "40.5" "39.7" "42.9" "72.9" "48.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2500202292612525864" "False" "Medium" "IsMasterProtein" "Q99623" "Prohibitin-2 OS=Homo sapiens OX=9606 GN=PHB2 PE=1 SV=2" "0.038" "False" "1.470" "3" "1" "1" "1" "299" "33.3" "9.83" "2.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01145" "11331" "ENSG00000215021" "PHB2" "B4DP75; hsa:11331; Q2YDA4; Q7KYU3; Q92978; Q99623" "Processing of SMDT1; Cellular response to mitochondrial stress" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6977987857049713242" "False" "Medium" "IsMasterProtein" "Q14159" "DNA repair-scaffolding protein OS=Homo sapiens OX=9606 GN=SPIDR PE=1 SV=2" "0.038" "False" "1.466" "2" "1" "1" "1" "915" "100.3" "6.62" "0.00" "1" "DNA metabolism;stress response;other biological processes" "nucleus" "" "Pf14950, Pf14951" "23514" "ENSG00000164808" "SPIDR" "B4DFV2; B4E0Y6; hsa:23514; Q14159; Q96BI5" "Resolution of D-loop Structures through Holliday Junction Intermediates" "Primary ovarian insufficiency" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "Not Found" "1" "" "190648059904117416" "False" "Medium" "IsMasterProtein" "Q9UQ90" "Mitochondrial inner membrane m-AAA protease component paraplegin OS=Homo sapiens OX=9606 GN=SPG7 PE=1 SV=2" "0.038" "False" "1.464" "2" "1" "1" "1" "795" "88.2" "8.69" "1.84" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf01434, Pf06480, Pf17862" "6687" "ENSG00000197912" "SPG7" "hsa:6687; O75756; Q2TB70; Q58F00; Q96IB0; Q9UQ90" "Mitochondrial protein degradation; Processing of SMDT1" "" "2" "0" "1.171" "0.958" "1.316" "1.455" "1.082" "1.515" "1.237" "1.131" "1.212" "40.7" "47.7" "39.0" "53.6" "59.3" "44.1" "61.8" "50.4" "46.1" "49.4" "" "" "" "" "" "" "" "" "" "" "32.7" "34.4" "31.0" "35.9" "41.0" "33.1" "43.2" "36.8" "46.1" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6070529034068729651" "False" "Medium" "IsMasterProtein" "Q8TEV9" "Guanine nucleotide exchange protein SMCR8 OS=Homo sapiens OX=9606 GN=SMCR8 PE=1 SV=2" "0.038" "False" "1.460" "1" "1" "1" "1" "937" "105.0" "5.58" "0.00" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11704" "140775" "ENSG00000176994; ENSG00000283741" "SMCR8" "A5PKZ5; hsa:140775; Q3ZCN0; Q6PJL3; Q8TEV9" "" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "343969761747531800" "False" "Medium" "IsMasterProtein" "Q9C0G0" "Zinc finger protein 407 OS=Homo sapiens OX=9606 GN=ZNF407 PE=1 SV=2" "0.039" "False" "1.447" "1" "1" "1" "1" "2248" "247.2" "6.49" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "55628" "ENSG00000215421" "ZNF407" "B5MD54; hsa:55628; Q96MY0; Q9C0G0; Q9H8A1; Q9NXD4; Q9NXD7" "" "" "0" "0" "1.542" "1.193" "1.508" "1.653" "1.160" "1.178" "1.293" "1.064" "1.374" "21.7" "33.5" "25.9" "32.7" "35.9" "25.2" "25.6" "28.1" "23.1" "29.8" "" "" "" "" "" "" "" "" "" "" "17.4" "24.1" "20.6" "21.9" "24.8" "18.9" "17.9" "20.5" "23.1" "24.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7425401848780502306" "False" "Medium" "IsMasterProtein" "Q8NDW4" "Zinc finger protein 248 OS=Homo sapiens OX=9606 GN=ZNF248 PE=1 SV=1" "0.039" "False" "1.447" "1" "1" "2" "1" "579" "67.0" "8.25" "4.24" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "57209" "ENSG00000198105" "ZNF248" "hsa:57209; Q8NDV8; Q8NDW4; Q9UMP3" "Generic Transcription Pathway" "" "1" "0" "0.872" "0.910" "1.039" "0.992" "1.150" "0.948" "0.761" "1.036" "1.056" "36.7" "32.1" "33.4" "38.2" "36.5" "42.3" "34.8" "28.0" "38.1" "38.8" "" "" "" "" "" "" "" "" "" "" "29.5" "23.1" "26.6" "25.6" "25.2" "31.7" "24.4" "20.4" "38.1" "31.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1778360088821123392" "False" "Medium" "IsMasterProtein" "Q5T655" "Cilia- and flagella-associated protein 58 OS=Homo sapiens OX=9606 GN=CFAP58 PE=1 SV=1" "0.039" "False" "1.447" "2" "1" "1" "1" "872" "103.4" "8.41" "0.00" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;other cell component" "" "Pf21771" "159686" "ENSG00000120051" "CFAP58" "D3DRA6; hsa:159686; Q5T655; Q8NA27" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3496599989848097415" "False" "Medium" "IsMasterProtein" "Q9ULG6" "Cell cycle progression protein 1 OS=Homo sapiens OX=9606 GN=CCPG1 PE=1 SV=3" "0.039" "False" "1.446" "1" "1" "1" "1" "757" "87.3" "5.95" "0.00" "1" "cell cycle OR cell proliferation;other biological processes" "other membranes" "" "" "9236" "ENSG00000260916" "CCPG1" "A0PJH3; A8K9T0; hsa:9236; O14712; Q05DG4; Q5U5S7; Q8IYV8; Q9BY53; Q9HA17; Q9ULG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7962902764123789471" "False" "Medium" "IsMasterProtein" "Q9BRC7" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 OS=Homo sapiens OX=9606 GN=PLCD4 PE=1 SV=1" "0.039" "False" "1.446" "2" "1" "1" "1" "762" "87.5" "5.21" "2.47" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00387, Pf00388, Pf09279, Pf13202" "84812" "ENSG00000115556" "PLCD4" "hsa:84812; Q53FS8; Q9BRC7" "Synthesis of IP3 and IP4 in the cytosol" "Serotonin and anxiety-related events; Serotonin and anxiety; Resistin as a regulator of inflammation" "4" "0" "1.085" "0.970" "0.988" "1.014" "0.948" "0.914" "0.985" "0.938" "1.077" "208.7" "226.3" "202.5" "206.1" "211.6" "197.8" "190.8" "205.5" "195.8" "224.7" "" "" "" "" "" "" "" "" "" "" "167.6" "163.3" "160.8" "138.1" "146.4" "148.4" "133.6" "150.1" "195.8" "182.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4518247563502183422" "False" "Medium" "IsMasterProtein" "O75443" "Alpha-tectorin OS=Homo sapiens OX=9606 GN=TECTA PE=1 SV=3" "0.039" "False" "1.445" "0" "1" "1" "1" "2155" "239.4" "5.40" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes" "extracellular structural activity" "Pf00094, Pf00100, Pf01826, Pf06119, Pf08742, Pf12714" "7007" "ENSG00000109927" "TECTA" "hsa:7007; O75443" "Post-translational modification: synthesis of GPI-anchored proteins" "" "1" "0" "0.943" "0.942" "0.973" "1.340" "1.216" "1.310" "1.137" "1.008" "1.214" "107.3" "101.1" "101.1" "104.4" "143.7" "130.5" "140.6" "122.0" "108.1" "130.3" "" "" "" "" "" "" "" "" "" "" "86.2" "73.0" "80.3" "69.9" "99.4" "97.9" "98.4" "89.1" "108.1" "105.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8935663415692527601" "False" "Medium" "IsMasterProtein" "Q68DL7" "Uncharacterized protein C18orf63 OS=Homo sapiens OX=9606 GN=C18orf63 PE=1 SV=2" "0.039" "False" "1.445" "1" "1" "1" "1" "685" "77.2" "9.80" "2.46" "1" "" "" "" "Pf15813" "644041" "ENSG00000206043" "C18orf63" "A6NME8; hsa:644041; Q68DL7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1087953670680093923" "False" "Medium" "IsMasterProtein" "Q9UHV2" "SERTA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SERTAD1 PE=1 SV=2" "0.039" "False" "1.438" "6" "1" "1" "1" "236" "24.7" "4.42" "2.21" "1" "other biological processes" "cytosol;nucleus" "" "Pf06031" "29950" "ENSG00000197019" "SERTAD1" "hsa:29950; Q9BUE7; Q9UHV2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "644773840200945729" "False" "Medium" "IsMasterProtein" "Q96L94" "Sorting nexin-22 OS=Homo sapiens OX=9606 GN=SNX22 PE=1 SV=1" "0.039" "False" "1.436" "4" "1" "2" "1" "193" "22.1" "9.55" "2.72" "1" "transport" "other membranes" "other molecular function" "Pf00787" "79856" "ENSG00000157734" "SNX22" "hsa:79856; Q8WUS9; Q96L94; Q9H844" "" "" "0" "0" "1.036" "1.168" "0.866" "1.099" "1.065" "1.004" "1.036" "0.988" "1.026" "54.1" "56.1" "63.2" "46.9" "59.5" "57.6" "54.3" "56.1" "53.5" "55.5" "" "" "" "" "" "" "" "" "" "" "43.5" "40.5" "50.2" "31.4" "41.1" "43.2" "38.0" "41.0" "53.5" "45.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7042305927855089094" "False" "Medium" "IsMasterProtein" "Q96E09" "PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 OS=Homo sapiens OX=9606 GN=PABIR1 PE=1 SV=1" "0.040" "False" "1.435" "3" "1" "2" "1" "287" "30.5" "6.79" "1.96" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "" "116224" "ENSG00000187866" "PABIR1" "hsa:116224; Q96E09" "" "" "0" "0" "0.919" "0.974" "0.990" "0.979" "1.037" "1.019" "1.033" "1.016" "1.026" "233.1" "214.3" "227.0" "230.7" "228.1" "241.7" "237.6" "240.8" "236.9" "239.1" "" "" "" "" "" "" "" "" "" "" "187.2" "154.6" "180.3" "154.6" "157.8" "181.3" "166.4" "175.8" "236.9" "194.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6426699249813695789" "False" "Medium" "IsMasterProtein" "Q9UBY0" "Sodium/hydrogen exchanger 2 OS=Homo sapiens OX=9606 GN=SLC9A2 PE=1 SV=1" "0.040" "False" "1.430" "1" "1" "1" "1" "812" "91.5" "9.09" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf00999, Pf16644" "6549" "ENSG00000115616" "SLC9A2" "B2RMS2; hsa:6549; Q9UBY0" "Sodium/Proton exchangers" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "Not Found" "1" "" "-4738294880547824619" "False" "Medium" "IsMasterProtein" "Q9BQ15" "SOSS complex subunit B1 OS=Homo sapiens OX=9606 GN=NABP2 PE=1 SV=1" "0.040" "False" "1.427" "3" "1" "1" "1" "211" "22.3" "9.06" "2.39" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21473" "79035" "ENSG00000139579" "NABP2" "A6NDF8; hsa:79035; Q6XYC8; Q9BQ15" "RNA polymerase II transcribes snRNA genes" "Mesodermal commitment pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "743722838785437812" "False" "Medium" "IsMasterProtein" "Q12846" "Syntaxin-4 OS=Homo sapiens OX=9606 GN=STX4 PE=1 SV=2" "0.040" "False" "1.425" "3" "1" "1" "1" "297" "34.2" "6.28" "2.10" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00804, Pf05739" "6810" "ENSG00000103496" "STX4" "A8MXY0; hsa:6810; Q12846; Q15525; Q6FHE8" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; ER-Phagosome pathway; trans-Golgi Network Vesicle Budding; Disinhibition of SNARE formation; Other interleukin signaling" "Insulin signaling; Vasopressin-regulated water reabsorption" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7531321553929023079" "False" "Medium" "IsMasterProtein" "Q69YI7" "Nuclear apoptosis-inducing factor 1 OS=Homo sapiens OX=9606 GN=NAIF1 PE=1 SV=1" "0.040" "False" "1.425" "2" "1" "1" "1" "327" "35.1" "7.21" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus" "" "Pf13873" "203245" "ENSG00000171169" "NAIF1" "B3KV81; hsa:203245; Q69YI7; Q8WU12" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852321507511147848" "False" "Medium" "IsMasterProtein" "O15455" "Toll-like receptor 3 OS=Homo sapiens OX=9606 GN=TLR3 PE=1 SV=1" "0.040" "False" "1.424" "1" "1" "1" "1" "904" "103.8" "7.18" "2.59" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00560, Pf01582, Pf13516, Pf13855, Pf17968" "7098" "ENSG00000164342" "TLR3" "B2RAI7; B7Z7K0; E6Y0F0; E6Y0F1; E9PGH4; hsa:7098; O15455; Q4VAL2; Q504W0" "RSV-host interactions; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; Trafficking and processing of endosomal TLR; TLR3 deficiency - HSE; UNC93B1 deficiency - HSE; TICAM1 deficiency - HSE; TRAF3 deficiency - HSE; TLR3-mediated TICAM1-dependent programmed cell death; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex" "Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Acute viral myocarditis; Hepatitis B infection; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; Burn wound healing; Lung pathology of COVID-19; Toll-like receptor signaling pathway" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6408884538734693617" "False" "Medium" "IsMasterProtein" "Q8IWZ6" "Bardet-Biedl syndrome 7 protein OS=Homo sapiens OX=9606 GN=BBS7 PE=1 SV=2" "0.040" "False" "1.423" "2" "1" "1" "1" "715" "80.3" "6.05" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "55212" "ENSG00000138686" "BBS7" "hsa:55212; Q4W5P8; Q8IWZ6; Q8N581; Q9NVI4" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8808968568097127538" "False" "Medium" "IsMasterProtein" "A6NE01" "Protein FAM186A OS=Homo sapiens OX=9606 GN=FAM186A PE=1 SV=3" "0.041" "False" "1.420" "1" "1" "2" "1" "2351" "262.6" "8.60" "5.82" "1" "" "" "" "Pf20865, Pf20869, Pf20870" "121006" "ENSG00000185958" "FAM186A" "A6NE01; hsa:121006" "" "" "0" "0" "1.029" "1.023" "0.913" "0.988" "1.010" "0.868" "1.054" "1.012" "1.015" "245.6" "252.7" "251.3" "224.3" "242.7" "247.9" "213.2" "258.8" "248.5" "249.3" "" "" "" "" "" "" "" "" "" "" "197.2" "182.3" "199.6" "150.3" "167.9" "186.0" "149.2" "189.0" "248.5" "202.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3778261161169107629" "False" "Medium" "IsMasterProtein" "A8MPP1" "Putative ATP-dependent DNA helicase DDX11-like protein 8 OS=Homo sapiens OX=9606 GN=DDX11L8 PE=1 SV=1" "0.041" "False" "1.417" "1" "1" "1" "1" "907" "101.7" "7.47" "1.89" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06733, Pf13307" "" "" "DDX11L8" "A8MPP1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "904242139103255563" "False" "Medium" "IsMasterProtein" "Q8TF21" "Ankyrin repeat domain-containing protein 24 OS=Homo sapiens OX=9606 GN=ANKRD24 PE=1 SV=2" "0.041" "False" "1.415" "2" "1" "1" "1" "1146" "124.1" "5.01" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity" "Pf00023, Pf12796" "170961" "ENSG00000089847" "ANKRD24" "hsa:170961; O75268; O95781; Q8TF21" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6501697818920195355" "False" "Medium" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "0.041" "False" "1.411" "3" "1" "1" "1" "282" "31.5" "5.52" "1.99" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "1.089" "1.871" "2.821" "2.395" "1.944" "1.016" "1.018" "1.070" "1.657" "160.1" "174.4" "299.6" "451.8" "383.6" "311.4" "162.7" "163.1" "171.3" "265.3" "" "" "" "" "" "" "" "" "" "" "128.6" "125.9" "237.9" "302.7" "265.3" "233.6" "113.9" "119.1" "171.3" "215.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5973761010667615261" "False" "Medium" "IsMasterProtein" "Q86Y07" "Serine/threonine-protein kinase VRK2 OS=Homo sapiens OX=9606 GN=VRK2 PE=1 SV=3" "0.041" "False" "1.405" "1" "1" "1" "1" "508" "58.1" "8.84" "2.55" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7444" "ENSG00000028116" "VRK2" "B4DKL0; D6W5D4; D6W5D6; hsa:7444; Q49AK9; Q53EU9; Q53S39; Q53S77; Q53TU1; Q86Y07; Q86Y08; Q86Y09; Q86Y10; Q86Y11; Q86Y12; Q8IXI5; Q99987" "RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "" "5" "0" "0.960" "1.063" "1.002" "1.068" "1.034" "1.163" "1.049" "1.232" "1.159" "56.6" "54.3" "60.2" "56.7" "60.5" "58.6" "65.8" "59.4" "69.8" "65.6" "" "" "" "" "" "" "" "" "" "" "45.5" "39.2" "47.8" "38.0" "41.8" "43.9" "46.1" "43.4" "69.8" "53.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8885735133454120700" "False" "Medium" "IsMasterProtein" "Q13277" "Syntaxin-3 OS=Homo sapiens OX=9606 GN=STX3 PE=1 SV=3" "0.042" "False" "1.401" "3" "1" "1" "1" "289" "33.1" "5.44" "2.08" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00804, Pf05739" "6809" "ENSG00000166900" "STX3" "B4DME0; hsa:6809; O43750; O43751; Q13277; Q15360" "Other interleukin signaling" "Synaptic vesicle pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751858567189414303" "False" "Medium" "IsMasterProtein" "Q9Y4U1" "Cyanocobalamin reductase / alkylcobalamin dealkylase OS=Homo sapiens OX=9606 GN=MMACHC PE=1 SV=3" "0.042" "False" "1.398" "4" "1" "1" "1" "282" "31.7" "7.81" "1.78" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf16690" "25974" "ENSG00000132763" "MMACHC" "hsa:25974; Q5T157; Q9BRQ7; Q9Y4U1" "Cobalamin (Cbl) metabolism; Defective MMADHC causes MMAHCD; Defective MMACHC causes MAHCC" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7440920222201792671" "False" "Medium" "IsMasterProtein" "O15217" "Glutathione S-transferase A4 OS=Homo sapiens OX=9606 GN=GSTA4 PE=1 SV=1" "0.042" "False" "1.393" "3" "1" "1" "1" "222" "25.7" "8.27" "0.00" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf02798, Pf14497" "2941" "ENSG00000170899" "GSTA4" "B2RD15; hsa:2941; O15217; Q5T7Q8; Q6P4G1; Q9BX18; Q9H414" "Glutathione conjugation" "Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990155463246362264" "False" "Medium" "IsMasterProtein" "Q8NHB8" "Olfactory receptor 5K2 OS=Homo sapiens OX=9606 GN=OR5K2 PE=1 SV=3" "0.042" "False" "1.393" "2" "1" "1" "1" "316" "35.7" "8.06" "2.32" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "402135" "ENSG00000231861" "OR5K2" "B2RN70; hsa:402135; Q6IF47; Q8NHB8" "Expression and translocation of olfactory receptors" "" "1" "0" "0.968" "0.951" "1.029" "0.765" "0.953" "0.813" "0.733" "1.047" "0.889" "85.0" "82.2" "80.8" "87.5" "65.0" "81.0" "69.1" "62.3" "89.0" "75.5" "" "" "" "" "" "" "" "" "" "" "68.3" "59.3" "64.2" "58.6" "45.0" "60.8" "48.4" "45.5" "89.0" "61.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926875629278284651" "False" "Medium" "IsMasterProtein" "Q9UKV5" "E3 ubiquitin-protein ligase AMFR OS=Homo sapiens OX=9606 GN=AMFR PE=1 SV=2" "0.042" "False" "1.391" "1" "1" "1" "1" "643" "72.9" "6.39" "1.75" "1" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf02845, Pf13639, Pf18442" "267" "ENSG00000159461" "AMFR" "hsa:267; P26442; Q8IZ70; Q9UKV5" "ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Sterol regulatory element-binding proteins (SREBP) signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6242890484097416684" "False" "Medium" "IsMasterProtein" "Q05707" "Collagen alpha-1(XIV) chain OS=Homo sapiens OX=9606 GN=COL14A1 PE=1 SV=3" "0.043" "False" "1.388" "1" "1" "1" "1" "1796" "193.4" "5.30" "1.77" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "extracellular matrix;ER/Golgi;other cell component" "extracellular structural activity;other molecular function" "Pf00041, Pf00092, Pf01391" "7373" "ENSG00000187955" "COL14A1" "B2RU07; hsa:7373; O00260; O00261; O00262; Q05707; Q05708; Q5XJ18; Q96C67; Q9UDF6" "Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6018815086214202181" "False" "Medium" "IsMasterProtein" "Q8N6C5" "Immunoglobulin superfamily member 1 OS=Homo sapiens OX=9606 GN=IGSF1 PE=1 SV=3" "0.043" "False" "1.388" "1" "1" "1" "1" "1336" "148.8" "5.90" "0.00" "1" "other biological processes" "non-structural extracellular;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf13895" "3547" "ENSG00000147255" "IGSF1" "B5MEG2; H9KV64; hsa:3547; O15070; Q8N6C5; Q9NTC8" "" "" "0" "0" "1.518" "0.748" "0.817" "1.191" "1.253" "1.157" "0.458" "1.203" "0.812" "16.8" "25.4" "12.5" "13.7" "19.9" "21.0" "19.4" "7.7" "20.1" "13.6" "" "" "" "" "" "" "" "" "" "" "13.5" "18.3" "10.0" "9.2" "13.8" "15.8" "13.6" "5.6" "20.1" "11.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3009099087527459561" "False" "Medium" "IsMasterProtein" "Q92784" "Zinc finger protein DPF3 OS=Homo sapiens OX=9606 GN=DPF3 PE=1 SV=3" "0.043" "False" "1.386" "3" "1" "1" "1" "378" "43.1" "6.42" "1.81" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "8110" "ENSG00000205683" "DPF3" "A8MSI3; B7Z276; F5H575; hsa:8110; Q32UJ0; Q6P9E6; Q6ZT41; Q92784; Q9H7Y5" "" "Tumor suppressor activity of SMARCB1; Thermogenesis" "2" "0" "1.028" "1.024" "1.040" "1.201" "1.123" "1.069" "1.541" "1.280" "1.257" "19.3" "19.9" "19.8" "20.1" "23.2" "21.7" "20.6" "29.8" "24.7" "24.3" "" "" "" "" "" "" "" "" "" "" "15.5" "14.3" "15.7" "13.5" "16.0" "16.3" "14.5" "21.7" "24.7" "19.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5175550772712101410" "False" "Medium" "IsMasterProtein" "Q9NU02" "Ankyrin repeat and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKEF1 PE=1 SV=2" "0.044" "False" "1.381" "1" "1" "1" "1" "776" "86.6" "8.28" "2.79" "1" "" "" "other molecular function" "Pf12796" "63926" "ENSG00000132623" "ANKEF1" "B3KUQ0; hsa:63926; Q9H6Y9; Q9NU02" "" "" "0" "0" "1.036" "1.043" "1.032" "0.961" "1.050" "1.099" "1.064" "0.992" "1.077" "286.0" "296.3" "298.4" "295.3" "274.9" "300.2" "314.3" "304.2" "283.7" "308.0" "" "" "" "" "" "" "" "" "" "" "229.7" "213.8" "237.0" "197.9" "190.1" "225.3" "220.1" "222.2" "283.7" "250.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6372570130755295238" "False" "Medium" "IsMasterProtein" "Q5XUX0" "F-box only protein 31 OS=Homo sapiens OX=9606 GN=FBXO31 PE=1 SV=2" "0.044" "False" "1.381" "2" "1" "1" "1" "539" "60.6" "7.02" "1.63" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction" "cytosol;other cell component" "other molecular function" "Pf12014, Pf12937" "79791" "ENSG00000103264" "FBXO31" "hsa:79791; Q5K680; Q5XUX0; Q8WYV1; Q96D73; Q9UFV4" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5071844025737464693" "False" "Medium" "IsMasterProtein" "O95835" "Serine/threonine-protein kinase LATS1 OS=Homo sapiens OX=9606 GN=LATS1 PE=1 SV=1" "0.044" "False" "1.377" "1" "1" "1" "1" "1130" "126.8" "8.70" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf00627" "9113" "ENSG00000131023" "LATS1" "hsa:9113; O95835; Q6PKD0" "Signaling by Hippo" "Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "9" "0" "1.534" "1.300" "1.630" "1.653" "1.299" "1.833" "1.478" "1.156" "1.403" "15.7" "24.2" "20.5" "25.7" "26.0" "20.4" "28.9" "23.3" "18.2" "22.1" "" "" "" "" "" "" "" "" "" "" "12.6" "17.4" "16.3" "17.2" "18.0" "15.3" "20.2" "17.0" "18.2" "18.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2524855227183394076" "False" "Medium" "IsMasterProtein" "Q16678" "Cytochrome P450 1B1 OS=Homo sapiens OX=9606 GN=CYP1B1 PE=1 SV=2" "0.044" "False" "1.375" "2" "1" "1" "1" "543" "60.8" "8.98" "0.00" "1" "cell adhesion;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00067" "1545" "ENSG00000138061" "CYP1B1" "Q16678; Q5TZW8; Q93089; Q9H316" "Endogenous sterols; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET); Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE); Defective CYP1B1 causes Glaucoma" "Sulindac metabolic pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Melatonin metabolism and effects; Oxidation by cytochrome P450; Tamoxifen metabolism; Benzo(a)pyrene metabolism; Estrogen metabolism; Metapathway biotransformation Phase I and II" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3056422399834274197" "False" "Medium" "IsMasterProtein" "Q8WX94" "NACHT, LRR and PYD domains-containing protein 7 OS=Homo sapiens OX=9606 GN=NLRP7 PE=1 SV=1" "0.044" "False" "1.374" "1" "1" "1" "1" "980" "111.7" "6.23" "1.85" "1" "other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf02758, Pf05729, Pf13516, Pf17776, Pf17779" "199713" "ENSG00000167634; ENSG00000274174; ENSG00000274571; ENSG00000275483; ENSG00000276804; ENSG00000277071; ENSG00000277179; ENSG00000277776; ENSG00000277786" "NLRP7" "E9PE16; hsa:199713; Q32MH8; Q7RTR1; Q8WX94" "" "Nucleotide-binding oligomerization domain (NOD) pathway" "1" "0" "1.019" "0.756" "1.029" "0.843" "0.989" "0.783" "0.761" "0.872" "0.912" "92.9" "94.7" "70.3" "95.6" "78.3" "91.9" "72.8" "70.7" "81.0" "84.8" "" "" "" "" "" "" "" "" "" "" "74.6" "68.3" "55.8" "64.1" "54.2" "69.0" "51.0" "51.6" "81.0" "69.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1642707608510955172" "False" "Medium" "IsMasterProtein" "Q702N8" "Xin actin-binding repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=XIRP1 PE=1 SV=1" "0.045" "False" "1.370" "1" "1" "1" "1" "1843" "198.4" "6.15" "2.31" "1" "cell organization and biogenesis;other biological processes" "other cell component" "cytoskeletal activity" "Pf08043" "165904" "ENSG00000168334" "XIRP1" "A0JP25; A4QPE2; hsa:165904; Q68DF2; Q6ZTR3; Q702N8; Q702N9; Q8IVN7; Q8N1N3; Q8N904; Q8TCG7" "" "" "0" "0" "0.989" "0.958" "1.026" "0.893" "0.823" "1.057" "0.741" "0.830" "0.861" "35.3" "34.9" "33.8" "36.2" "31.5" "29.0" "37.3" "26.2" "29.3" "30.4" "" "" "" "" "" "" "" "" "" "" "28.3" "25.2" "26.8" "24.2" "21.8" "21.8" "26.1" "19.1" "29.3" "24.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4159825271263459445" "False" "Medium" "IsMasterProtein" "B6SEH9" "Endogenous retrovirus group V member 2 Env polyprotein OS=Homo sapiens OX=9606 GN=ERVV-2 PE=1 SV=1" "0.045" "False" "1.363" "4" "1" "1" "1" "535" "59.3" "8.53" "0.00" "1" "" "other membranes" "" "Pf00429" "100271846" "ENSG00000268964" "ERVV-2" "B6SEH9; hsa:100271846" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "836020485992542611" "False" "Medium" "IsMasterProtein" "Q9Y6Q2" "Stonin-1 OS=Homo sapiens OX=9606 GN=STON1 PE=1 SV=2" "0.045" "False" "1.362" "2" "1" "1" "1" "735" "83.1" "6.20" "2.43" "1" "cell adhesion;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00928" "11037; 286749" "ENSG00000243244" "STON1" "A0A0A6YYH4; A8MXJ1; B5MCF5; B7ZL16; hsa:11037; hsa:286749; Q96JE3; Q9BYX3; Q9Y6Q2" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3560760707148730890" "False" "Medium" "IsMasterProtein" "Q9GZK7" "Olfactory receptor 11A1 OS=Homo sapiens OX=9606 GN=OR11A1 PE=2 SV=1" "0.046" "False" "1.359" "2" "1" "2" "1" "315" "35.2" "7.87" "4.71" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "26531" "ENSG00000204694; ENSG00000206472; ENSG00000206517; ENSG00000223898; ENSG00000230780; ENSG00000232289; ENSG00000234347; ENSG00000237258" "OR11A1" "A2BF33; A6NFQ3; B0S7T2; hsa:26531; Q5ST16; Q9GZK7; Q9GZK8" "Expression and translocation of olfactory receptors; Olfactory Signaling Pathway" "GPCRs, class A rhodopsin-like" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-903234592047053827" "False" "Medium" "IsMasterProtein" "Cont_Q7M135" "Lysyl endopeptidase OS=Lysobacter enzymogenes OX=69 PE=1 SV=1" "0.046" "True" "1.353" "7" "1" "1" "1" "269" "27.9" "6.71" "0.00" "1" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf13365" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5621842442587442909" "False" "Medium" "IsMasterProtein" "Q6ZNA5" "Ferric-chelate reductase 1 OS=Homo sapiens OX=9606 GN=FRRS1 PE=1 SV=2" "0.046" "False" "1.351" "1" "1" "1" "1" "592" "66.1" "7.47" "2.81" "1" "other biological processes" "other membranes" "other molecular function" "Pf02014, Pf03351" "391059" "ENSG00000156869" "FRRS1" "A6NLN7; hsa:391059; Q6ZNA5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4503550903694701286" "False" "Medium" "IsMasterProtein" "O60504" "Vinexin OS=Homo sapiens OX=9606 GN=SORBS3 PE=1 SV=2" "0.047" "False" "1.349" "2" "1" "1" "1" "671" "75.3" "9.45" "2.05" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00018, Pf02208, Pf14604" "10174" "ENSG00000120896" "SORBS3" "hsa:10174; O60504; Q5BJE4; Q6NX54; Q96FY4; Q9UQE4" "Smooth Muscle Contraction" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119616111706856744" "False" "Medium" "IsMasterProtein" "Q9ULZ3" "Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2" "0.047" "False" "1.342" "4" "1" "1" "1" "195" "21.6" "6.34" "2.89" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00619, Pf02758" "29108" "ENSG00000103490" "PYCARD" "hsa:29108; Q96D12; Q9BSZ5; Q9HBD0; Q9NXJ8; Q9ULZ3" "Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CLEC7A/inflammasome pathway" "Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling" "13" "0" "0.893" "0.914" "1.052" "1.069" "0.898" "1.072" "0.984" "0.960" "0.966" "239.3" "213.7" "218.8" "251.7" "255.9" "214.8" "256.5" "235.4" "229.9" "231.1" "" "" "" "" "" "" "" "" "" "" "192.2" "154.2" "173.8" "168.6" "177.0" "161.2" "179.6" "171.9" "229.9" "188.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "436282700212558245" "False" "Medium" "IsMasterProtein" "P17676" "CCAAT/enhancer-binding protein beta OS=Homo sapiens OX=9606 GN=CEBPB PE=1 SV=2" "0.047" "False" "1.342" "2" "1" "1" "1" "345" "36.1" "8.31" "2.05" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1051" "ENSG00000172216" "CEBPB" "A8K671; hsa:1051; P17676; Q96IH2; Q9H4Z5" "Transcriptional regulation of white adipocyte differentiation; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Transcriptional regulation of granulopoiesis; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency; Nuclear events stimulated by ALK signaling in cancer" "Folate-alcohol and cancer pathway hypotheses; IL-17 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Differentiation of white and brown adipocyte; Transcriptional activation by NRF2 in response to phytochemicals; Ovarian infertility; Transcription factor regulation in adipogenesis; Lung fibrosis; IL-4 signaling pathway; Exercise-induced circadian regulation; White fat cell differentiation; Transcriptional cascade regulating adipogenesis; NRF2-ARE regulation; IL-18 signaling pathway; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2658626419625283568" "False" "Medium" "IsMasterProtein" "Q8IYW2" "Cilia- and flagella-associated protein 46 OS=Homo sapiens OX=9606 GN=CFAP46 PE=1 SV=3" "0.047" "False" "1.342" "1" "1" "1" "1" "2715" "303.3" "7.36" "2.04" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton" "" "Pf03568" "54777" "ENSG00000171811" "CFAP46" "B1AP44; B7WPK8; hsa:54777; Q5JSF7; Q5SR76; Q5SR77; Q86ST2; Q8IYW2; Q8N777; Q9NTQ5" "" "" "0" "0" "0.997" "1.107" "1.168" "1.121" "1.073" "0.939" "1.041" "1.088" "1.103" "117.1" "116.8" "129.6" "136.8" "131.2" "125.6" "109.9" "121.9" "127.4" "129.1" "" "" "" "" "" "" "" "" "" "" "94.0" "84.3" "102.9" "91.6" "90.7" "94.2" "76.9" "89.0" "127.4" "105.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366588963976504067" "False" "Medium" "IsMasterProtein" "A0AV96" "RNA-binding protein 47 OS=Homo sapiens OX=9606 GN=RBM47 PE=1 SV=2" "0.047" "False" "1.338" "2" "1" "1" "1" "593" "64.1" "7.68" "2.21" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "54502" "ENSG00000163694" "RBM47" "A0AV96; A0PJK2; B5MED4; hsa:54502; Q8NI52; Q8NI53; Q9NXG3" "" "TYROBP causal network in microglia" "1" "0" "0.903" "1.027" "1.112" "0.855" "0.957" "1.025" "0.925" "1.143" "1.021" "93.5" "84.4" "96.1" "104.0" "80.0" "89.5" "95.9" "86.5" "106.9" "95.5" "" "" "" "" "" "" "" "" "" "" "75.1" "60.9" "76.3" "69.7" "55.3" "67.2" "67.1" "63.2" "106.9" "77.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717831225161761415" "False" "Medium" "IsMasterProtein" "P46100" "Transcriptional regulator ATRX OS=Homo sapiens OX=9606 GN=ATRX PE=1 SV=6" "0.047" "False" "1.336" "0" "1" "1" "1" "2492" "282.4" "6.55" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf17981" "546" "ENSG00000085224" "ATRX" "D3DTE2; P46100; P51068; Q15886; Q59FB5; Q59H31; Q5H9A2; Q5JWI4; Q7Z2J1; Q9H0Z1; Q9NTS3" "Inhibition of DNA recombination at telomere; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "Pathways affected in adenoid cystic carcinoma" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6181035115261308292" "False" "Medium" "IsMasterProtein" "Q8N7X0" "Androglobin OS=Homo sapiens OX=9606 GN=ADGB PE=1 SV=3" "0.047" "False" "1.336" "1" "1" "1" "1" "1667" "189.6" "8.31" "2.36" "1" "protein metabolism;other biological processes" "cytoskeleton" "other molecular function" "Pf00648" "79747" "ENSG00000118492" "ADGB" "hsa:79747; Q5T402; Q5T904; Q5T905; Q8N7X0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1510699374964662735" "False" "Medium" "IsMasterProtein" "P05408" "Neuroendocrine protein 7B2 OS=Homo sapiens OX=9606 GN=SCG5 PE=1 SV=2" "0.047" "False" "1.335" "9" "1" "1" "1" "212" "23.7" "5.96" "2.72" "1" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05281" "6447" "ENSG00000166922; ENSG00000277614; ENSG00000281931" "SCG5" "hsa:6447; P01164; P05408; Q6FHD0; Q9BS38" "" "" "0" "0" "0.859" "0.984" "1.104" "0.902" "0.920" "0.927" "1.046" "1.026" "0.956" "104.3" "89.6" "102.6" "115.1" "94.0" "95.9" "96.7" "109.1" "107.0" "99.7" "" "" "" "" "" "" "" "" "" "" "83.8" "64.6" "81.5" "77.1" "65.0" "72.0" "67.7" "79.7" "107.0" "81.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8767627751855325380" "False" "Medium" "IsMasterProtein" "Q9NWL6" "Asparagine synthetase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASNSD1 PE=1 SV=2" "0.047" "False" "1.335" "2" "1" "1" "1" "643" "72.0" "6.83" "0.00" "1" "other metabolic processes" "" "other molecular function" "Pf00733" "54529" "ENSG00000138381" "ASNSD1" "D3DPH6; hsa:54529; Q3LIC3; Q4ZG45; Q9NWL6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013128589362795023" "False" "Medium" "IsMasterProtein" "Q8TF20" "Zinc finger protein 721 OS=Homo sapiens OX=9606 GN=ZNF721 PE=1 SV=2" "0.047" "False" "1.335" "2" "1" "1" "1" "911" "105.0" "9.45" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "170960" "ENSG00000182903" "ZNF721" "hsa:170960; Q69YG7; Q8TF20" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7705626466042458302" "False" "Medium" "IsMasterProtein" "O75191" "Xylulose kinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=3" "0.047" "False" "1.333" "2" "1" "1" "1" "536" "58.3" "5.86" "2.33" "1" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00370, Pf02782" "9942" "ENSG00000093217" "XYLB" "B2RAW4; B4DDT2; B9EH64; hsa:9942; O75191" "Formation of xylulose-5-phosphate" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-651658770528502421" "False" "Medium" "IsMasterProtein" "P58499" "Protein FAM3B OS=Homo sapiens OX=9606 GN=FAM3B PE=1 SV=2" "0.047" "False" "1.333" "3" "1" "1" "1" "235" "26.0" "8.75" "2.16" "1" "cell-cell signaling;transport;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf15711" "54097" "ENSG00000183844" "FAM3B" "hsa:54097; P58499" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4328020828834409171" "False" "Medium" "IsMasterProtein" "Q9UBR1" "Beta-ureidopropionase OS=Homo sapiens OX=9606 GN=UPB1 PE=1 SV=1" "0.047" "False" "1.332" "2" "1" "1" "1" "384" "43.1" "6.54" "2.91" "1" "cell organization and biogenesis;other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00795" "51733" "ENSG00000100024" "UPB1" "A3KMF8; hsa:51733; Q9UBR1; Q9UIR3" "Pyrimidine catabolism" "Fluoropyrimidine activity; Pyrimidine metabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1123362264700484507" "False" "Medium" "IsMasterProtein" "Q9Y3R0" "Glutamate receptor-interacting protein 1 OS=Homo sapiens OX=9606 GN=GRIP1 PE=1 SV=3" "0.047" "False" "1.332" "1" "1" "1" "1" "1128" "122.3" "6.47" "3.08" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00595, Pf17820" "23426" "ENSG00000155974" "GRIP1" "C9JT59; hsa:23426; Q1RLM0; Q9Y3R0" "Trafficking of GluR2-containing AMPA receptors" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Fragile X syndrome; 7q11.23 copy number variation syndrome; Development of ureteric collection system" "5" "0" "0.942" "1.061" "1.153" "0.917" "0.993" "0.999" "0.861" "0.988" "0.989" "174.2" "164.1" "184.9" "201.0" "159.8" "173.0" "174.1" "150.0" "172.1" "172.2" "" "" "" "" "" "" "" "" "" "" "139.9" "118.4" "146.9" "134.7" "110.5" "129.8" "121.9" "109.5" "172.1" "140.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232931646907788143" "False" "Medium" "IsMasterProtein" "Q9H013" "Disintegrin and metalloproteinase domain-containing protein 19 OS=Homo sapiens OX=9606 GN=ADAM19 PE=1 SV=3" "0.047" "False" "1.331" "1" "1" "1" "1" "955" "104.9" "8.35" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf00200, Pf01421, Pf01562, Pf08516" "8728" "ENSG00000135074" "ADAM19" "hsa:8728; Q9BZL5; Q9H013; Q9UHP2" "Invadopodia formation; Regulation of CDH11 function" "Mesodermal commitment pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5874629891008926262" "False" "Medium" "IsMasterProtein" "Q14642" "Inositol polyphosphate-5-phosphatase A OS=Homo sapiens OX=9606 GN=INPP5A PE=1 SV=1" "0.048" "False" "1.329" "5" "1" "1" "1" "412" "47.8" "7.03" "2.18" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "" "3632" "ENSG00000068383" "INPP5A" "D3DXI3; hsa:3632; Q14640; Q14642; Q5JSF1" "Synthesis of IP2, IP, and Ins in the cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8201100139023696608" "False" "Medium" "IsMasterProtein" "Q02952" "A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4" "0.048" "False" "1.329" "1" "1" "1" "1" "1782" "191.4" "4.41" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03832, Pf10522" "9590" "ENSG00000131016" "AKAP12" "hsa:9590; O00310; O00498; Q02952; Q4LE68; Q5SZ80; Q5TGN1; Q68D82; Q99970" "RHOD GTPase cycle; RHOF GTPase cycle" "G protein signaling pathways" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8346227288620115762" "False" "Medium" "IsMasterProtein" "Q86TN4" "tRNA 2'-phosphotransferase 1 OS=Homo sapiens OX=9606 GN=TRPT1 PE=1 SV=2" "0.048" "False" "1.329" "4" "1" "1" "1" "253" "27.7" "9.98" "3.26" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01885" "83707" "ENSG00000149743" "TRPT1" "A8MU17; A8MYC9; F5H2B2; hsa:83707; Q86TN4; Q9BSB9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2651642788945973397" "False" "Medium" "IsMasterProtein" "Q4L180" "Filamin A-interacting protein 1-like OS=Homo sapiens OX=9606 GN=FILIP1L PE=1 SV=2" "0.048" "False" "1.324" "1" "1" "1" "1" "1135" "130.3" "6.57" "2.38" "1" "" "other membranes;nucleus;other cell component" "" "Pf09727" "11259" "ENSG00000168386" "FILIP1L" "B2CNV7; B2CNV8; hsa:11259; Q13597; Q2YDY5; Q4L180; Q6KFX5; Q6KFX6; Q6KFX7; Q8IUM3; Q8N6Z0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197609688232140172" "False" "Medium" "IsMasterProtein" "Q9UM01" "Y+L amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC7A7 PE=1 SV=2" "0.049" "False" "1.319" "5" "1" "1" "1" "511" "56.0" "5.43" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf13520" "9056" "ENSG00000155465" "SLC7A7" "B2RAU0; D3DS26; hsa:9056; O95984; Q53XC1; Q86U07; Q9P2V5; Q9UM01" "Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "TYROBP causal network in microglia; Proximal tubule transport" "5" "0" "1.135" "0.980" "1.390" "1.342" "1.792" "1.489" "1.400" "1.150" "1.163" "10.3" "11.7" "10.1" "14.3" "13.9" "18.5" "15.4" "14.4" "11.9" "12.0" "" "" "" "" "" "" "" "" "" "" "8.3" "8.4" "8.0" "9.6" "9.6" "13.9" "10.8" "10.6" "11.9" "9.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158641874839162528" "False" "Medium" "IsMasterProtein" "Q5JYT7" "Uncharacterized protein KIAA1755 OS=Homo sapiens OX=9606 GN=KIAA1755 PE=1 SV=2" "0.050" "False" "1.318" "1" "1" "2" "1" "1200" "130.8" "6.37" "4.92" "1" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "" "85449" "ENSG00000149633" "KIAA1755" "Q5JYT7; Q9C0A8" "" "" "0" "0" "0.940" "1.018" "0.924" "0.918" "0.947" "0.888" "0.758" "0.965" "1.000" "643.6" "604.7" "654.9" "594.4" "590.8" "609.6" "571.8" "487.7" "621.2" "643.3" "" "" "" "" "" "" "" "" "" "" "516.9" "436.3" "520.2" "398.3" "408.6" "457.4" "400.3" "356.2" "621.2" "523.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4881851844900072822" "False" "Medium" "IsMasterProtein" "Q4AC94" "C2 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=C2CD3 PE=1 SV=4" "0.050" "False" "1.317" "0" "1" "1" "1" "2353" "260.2" "7.12" "2.98" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton" "" "Pf00168" "26005" "ENSG00000168014" "C2CD3" "C9JR55; E2QRD1; hsa:26005; Q2NLE1; Q3C1U9; Q4AC94; Q6ZU92; Q8IYM4; Q8NB87; Q8NDH7; Q9Y4M2" "Anchoring of the basal body to the plasma membrane" "Genes related to primary cilium development (based on CRISPR); Ciliopathies" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "566098643970867289" "False" "Medium" "IsMasterProtein" "Q7Z3V5" "Zinc finger protein 571 OS=Homo sapiens OX=9606 GN=ZNF571 PE=1 SV=3" "0.050" "False" "1.315" "1" "1" "1" "1" "609" "70.7" "8.35" "1.64" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "51276" "ENSG00000180479" "ZNF571" "hsa:51276; Q2HIY0; Q3ZCU3; Q7Z3V5; Q9NZX7" "Generic Transcription Pathway" "" "1" "0" "1.073" "1.154" "1.157" "0.959" "1.136" "0.761" "0.942" "1.028" "1.091" "124.2" "133.3" "143.3" "143.7" "119.1" "141.1" "94.5" "117.0" "127.7" "135.5" "" "" "" "" "" "" "" "" "" "" "99.8" "96.2" "113.9" "96.3" "82.4" "105.9" "66.2" "85.4" "127.7" "110.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9070577819397538994" "False" "Medium" "IsMasterProtein" "P98174" "FYVE, RhoGEF and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FGD1 PE=1 SV=2" "0.050" "False" "1.315" "1" "1" "1" "1" "961" "106.5" "6.58" "2.27" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "2245" "ENSG00000102302" "FGD1" "hsa:2245; P98174; Q5H999; Q8N4D9" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "Regulation of actin cytoskeleton" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8786361054962067618" "False" "Low" "IsMasterProtein" "O00192" "Splicing regulator ARVCF OS=Homo sapiens OX=9606 GN=ARVCF PE=1 SV=1" "0.050" "False" "1.310" "1" "1" "1" "1" "962" "104.6" "6.81" "0.00" "1" "cell adhesion;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00514" "421" "ENSG00000099889" "ARVCF" "B7WNV2; hsa:421; O00192" "" "22q11.2 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3856255283194803531" "False" "Low" "IsMasterProtein" "Q53GG5" "PDZ and LIM domain protein 3 OS=Homo sapiens OX=9606 GN=PDLIM3 PE=1 SV=1" "0.050" "False" "1.309" "5" "1" "1" "1" "364" "39.2" "6.89" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "27295" "ENSG00000154553" "PDLIM3" "B2R866; hsa:27295; O43590; O60439; O60440; Q53GG5; Q8N6Y6; Q9BVP4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4925255109187835280" "False" "Low" "IsMasterProtein" "O95872" "G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1" "0.050" "False" "1.305" "3" "1" "1" "1" "356" "39.3" "8.19" "0.00" "1" "" "" "nucleic acid binding activity" "Pf01585, Pf13637" "7918" "ENSG00000204438; ENSG00000206408; ENSG00000223932; ENSG00000228605; ENSG00000232312; ENSG00000236011" "GPANK1" "A6NG25; B0UXA2; hsa:7918; O95872; Q5SQ49" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1288805438145348539" "False" "Low" "IsMasterProtein" "Q9GZP0" "Platelet-derived growth factor D OS=Homo sapiens OX=9606 GN=PDGFD PE=1 SV=1" "0.050" "False" "1.305" "2" "1" "1" "1" "370" "42.8" "7.97" "0.00" "1" "stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "signal transduction activity or receptor binding" "Pf00341, Pf00431" "80310" "ENSG00000170962" "PDGFD" "A8K9T6; hsa:80310; Q9BWV5; Q9GZP0" "Signaling by PDGF" "Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance; Angiotensin II receptor type 1 pathway; Pleural mesothelioma" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-146230353807069174" "False" "Low" "IsMasterProtein" "P08319" "All-trans-retinol dehydrogenase [NAD(+)] ADH4 OS=Homo sapiens OX=9606 GN=ADH4 PE=1 SV=5" "0.051" "False" "1.301" "2" "1" "1" "1" "380" "40.2" "7.94" "2.29" "1" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00107, Pf08240" "127" "ENSG00000198099" "ADH4" "A8K470; B4DIE7; C9J4A9; hsa:127; P08319; Q8TCD7" "RA biosynthesis pathway; Ethanol oxidation" "Fatty acid omega-oxidation; Amino acid metabolism; Vitamin A and carotenoid metabolism" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3789588988762427283" "False" "Low" "IsMasterProtein" "Q96FH0" "BLOC-1-related complex subunit 8 OS=Homo sapiens OX=9606 GN=BORCS8 PE=1 SV=1" "0.051" "False" "1.301" "8" "1" "1" "1" "119" "13.4" "5.80" "3.02" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10167" "729991" "ENSG00000254901" "BORCS8" "B2RXF9; hsa:729991; Q96FH0; Q9BT01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2798793094754646619" "False" "Low" "IsMasterProtein" "Q9HA92" "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=RSAD1 PE=1 SV=2" "0.051" "False" "1.298" "2" "1" "1" "1" "442" "48.7" "7.78" "0.00" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf04055, Pf06969" "55316" "ENSG00000136444" "RSAD1" "B4DMW0; hsa:55316; Q53HV8; Q86VC4; Q9BRY7; Q9HA92; Q9NUS7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316602667323924331" "False" "Low" "IsMasterProtein" "Q8IYA2" "Putative coiled-coil domain-containing protein 144C OS=Homo sapiens OX=9606 GN=CCDC144CP PE=5 SV=3" "0.051" "False" "1.295" "1" "1" "1" "1" "1237" "143.0" "5.69" "2.71" "1" "" "" "" "Pf12001, Pf14915" "" "" "CCDC144CP" "B7WNP5; Q8IYA2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2783430516031168393" "False" "Low" "IsMasterProtein" "Q8IYT2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 OS=Homo sapiens OX=9606 GN=CMTR2 PE=1 SV=2" "0.051" "False" "1.294" "1" "1" "1" "1" "770" "88.1" "7.01" "2.19" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01728" "55783" "ENSG00000180917" "CMTR2" "B2RCD5; D3DWS1; hsa:55783; Q8IYT2; Q8NE77; Q8NFR5; Q9H8Z4; Q9NUS3; Q9NXF5" "" "Pathways affected in adenoid cystic carcinoma" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6302302728029836571" "False" "Low" "IsMasterProtein" "Q13489" "Baculoviral IAP repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=BIRC3 PE=1 SV=2" "0.051" "False" "1.293" "3" "1" "1" "1" "604" "68.3" "6.04" "0.00" "1" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00653, Pf13920, Pf21290" "330" "ENSG00000023445" "BIRC3" "hsa:330; Q13489; Q16628; Q9HC27; Q9UP46" "NOD1/2 Signaling Pathway; Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; Regulation of necroptotic cell death; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Apoptosis; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; Photodynamic therapy-induced NF-kB survival signaling; Hepatitis C and hepatocellular carcinoma; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2484461728498550369" "False" "Low" "IsMasterProtein" "Q5VWN6" "Protein TASOR 2 OS=Homo sapiens OX=9606 GN=TASOR2 PE=1 SV=1" "0.051" "False" "1.291" "0" "1" "1" "1" "2430" "268.7" "5.90" "2.58" "1" "cell organization and biogenesis" "cytosol;nucleus" "" "Pf12480, Pf12509" "54906" "ENSG00000108021" "TASOR2" "hsa:54906; Q2YD91; Q5VWN5; Q5VWN6; Q6ZRQ8; Q8IVG4; Q9BUZ7; Q9H5J9; Q9H7A4; Q9H996; Q9NXA1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1127525944838097966" "False" "Low" "IsMasterProtein" "Q9P2D7" "Dynein axonemal heavy chain 1 OS=Homo sapiens OX=9606 GN=DNAH1 PE=1 SV=6" "0.051" "False" "1.287" "0" "1" "1" "1" "4265" "487.2" "5.83" "2.88" "1" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf03028, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf17857, Pf18198, Pf18199" "25981" "ENSG00000114841" "DNAH1" "B0I1R6; hsa:25981; O00436; O15435; O95491; Q6ZU48; Q86YK7; Q8TEJ4; Q92863; Q9H8E6; Q9P2D7; Q9UFW6; Q9Y4Z7" "" "" "0" "0" "1.180" "0.865" "1.026" "1.016" "1.109" "0.916" "0.917" "0.940" "1.026" "120.2" "141.8" "104.0" "123.4" "122.2" "133.4" "110.1" "110.2" "113.0" "123.4" "" "" "" "" "" "" "" "" "" "" "96.6" "102.3" "82.6" "82.7" "84.5" "100.1" "77.1" "80.5" "113.0" "100.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7837793363877166146" "False" "Low" "IsMasterProtein" "Q8IYX3" "Coiled-coil domain-containing protein 116 OS=Homo sapiens OX=9606 GN=CCDC116 PE=1 SV=3" "0.052" "False" "1.282" "4" "1" "1" "1" "613" "67.9" "8.54" "0.00" "1" "" "cytoskeleton;other cell component" "" "Pf15774" "164592" "ENSG00000161180" "CCDC116" "B7Z7H5; hsa:164592; Q8IYX3; Q8N9Y9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6110618285749793440" "False" "Low" "IsMasterProtein" "Q96PV7" "Protein FAM193B OS=Homo sapiens OX=9606 GN=FAM193B PE=1 SV=3" "0.052" "False" "1.282" "1" "1" "1" "1" "902" "96.5" "7.90" "0.00" "1" "" "nucleus;other cell component" "" "Pf15914" "" "ENSG00000146067" "FAM193B" "E9PET5; Q96PV7; Q9NW00" "" "5q35 copy number variation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526348281046255255" "False" "Low" "IsMasterProtein" "Q5SQS8" "Uncharacterized protein C10orf120 OS=Homo sapiens OX=9606 GN=C10orf120 PE=1 SV=1" "0.052" "False" "1.282" "3" "1" "1" "1" "335" "39.2" "9.44" "0.00" "1" "" "" "" "Pf17658" "399814" "ENSG00000183559" "C10orf120" "B2RU17; hsa:399814; Q5SQS8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4179589302645332535" "False" "Low" "IsMasterProtein" "Q96LK8" "Spermatogenesis-associated protein 32 OS=Homo sapiens OX=9606 GN=SPATA32 PE=1 SV=3" "0.052" "False" "1.280" "3" "1" "1" "1" "384" "42.3" "4.77" "0.00" "1" "other biological processes" "other cell component" "cytoskeletal activity" "Pf15310" "124783" "ENSG00000184361" "SPATA32" "hsa:124783; Q7Z4U1; Q8N6V6; Q96LK8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "795128292940512142" "False" "Low" "IsMasterProtein" "Q96IU2" "Zinc finger BED domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZBED3 PE=1 SV=1" "0.052" "False" "1.278" "4" "1" "1" "1" "234" "25.1" "8.31" "0.00" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892" "84327" "ENSG00000132846" "ZBED3" "hsa:84327; Q96IU2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-860365839376182297" "False" "Low" "IsMasterProtein" "Q9ULD2" "Microtubule-associated tumor suppressor 1 OS=Homo sapiens OX=9606 GN=MTUS1 PE=1 SV=2" "0.053" "False" "1.273" "1" "1" "1" "1" "1270" "141.3" "7.50" "2.28" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;nucleus" "cytoskeletal activity" "" "57509" "ENSG00000129422" "MTUS1" "A8K135; B2RBJ6; B3KWJ9; B4DH03; B9EGA1; D3DSP8; Q63HJ6; Q659F4; Q6PK49; Q6URW7; Q8N4M6; Q8WTT9; Q9H7T2; Q9ULD2" "" "" "0" "0" "1.233" "1.156" "0.914" "1.106" "1.241" "0.854" "1.089" "1.175" "1.203" "120.1" "148.1" "138.8" "109.8" "132.9" "149.1" "102.6" "130.8" "141.1" "144.5" "" "" "" "" "" "" "" "" "" "" "96.5" "106.9" "110.3" "73.6" "91.9" "111.9" "71.8" "95.5" "141.1" "117.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8100035487755028303" "False" "Low" "IsMasterProtein" "P51957" "Serine/threonine-protein kinase Nek4 OS=Homo sapiens OX=9606 GN=NEK4 PE=1 SV=2" "0.053" "False" "1.269" "1" "1" "1" "1" "841" "94.5" "7.90" "2.06" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf00069" "6787" "ENSG00000114904" "NEK4" "A5YM70; B2R633; B7Z200; P51957; Q6P576" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4987267089560076108" "False" "Low" "IsMasterProtein" "P25391" "Laminin subunit alpha-1 OS=Homo sapiens OX=9606 GN=LAMA1 PE=1 SV=2" "0.053" "False" "1.269" "0" "1" "1" "1" "3075" "336.9" "6.35" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;other cell component" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00052, Pf00053, Pf00054, Pf00055, Pf06008, Pf06009" "284217" "ENSG00000101680" "LAMA1" "hsa:284217; P25391" "ECM proteoglycans; Non-integrin membrane-ECM interactions; L1CAM interactions; Laminin interactions; MET activates PTK2 signaling" "Alpha 6 beta 4 signaling pathway; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Small cell lung cancer; Pleural mesothelioma" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005815971150446090" "False" "Low" "IsMasterProtein" "Q8IX03" "Protein KIBRA OS=Homo sapiens OX=9606 GN=WWC1 PE=1 SV=1" "0.053" "False" "1.268" "1" "1" "1" "1" "1113" "125.2" "5.85" "2.02" "1" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00397" "23286" "ENSG00000113645" "WWC1" "B4DK05; hsa:23286; O94946; Q6MZX4; Q6Y2F8; Q7Z4G8; Q8IX03; Q8WVM4; Q9BT29" "Signaling by Hippo; NOTCH3 Intracellular Domain Regulates Transcription" "Pleural mesothelioma" "3" "0" "0.930" "0.859" "1.132" "1.155" "1.175" "1.094" "0.946" "1.031" "1.166" "95.7" "89.0" "82.2" "108.3" "110.5" "112.4" "104.6" "90.5" "98.7" "111.5" "" "" "" "" "" "" "" "" "" "" "76.8" "64.2" "65.3" "72.5" "76.4" "84.3" "73.3" "66.1" "98.7" "90.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5314510564682491561" "False" "Low" "IsMasterProtein" "Q6ZV29" "Patatin-like phospholipase domain-containing protein 7 OS=Homo sapiens OX=9606 GN=PNPLA7 PE=1 SV=4" "0.053" "False" "1.265" "1" "1" "1" "1" "1317" "145.6" "7.74" "0.00" "1" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00027, Pf01734" "375775" "ENSG00000130653" "PNPLA7" "B5MDD3; hsa:375775; Q5T364; Q658X0; Q658Y3; Q6ZTS1; Q6ZV29; Q86YU8; Q8TAY5; Q96N75; Q9H7N5" "Glycerophospholipid catabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4386101623326845776" "False" "Low" "IsMasterProtein" "Q9Y4F5" "Centrosomal protein of 170 kDa protein B OS=Homo sapiens OX=9606 GN=CEP170B PE=1 SV=4" "0.054" "False" "1.261" "1" "1" "1" "1" "1589" "171.6" "6.84" "0.00" "1" "" "cytoskeleton;other cell component" "" "Pf00498, Pf15308" "283638" "ENSG00000099814" "CEP170B" "hsa:283638; Q2KHR7; Q86TI7; Q9Y4F5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3816864515849406131" "False" "Low" "IsMasterProtein" "O95696" "Bromodomain-containing protein 1 OS=Homo sapiens OX=9606 GN=BRD1 PE=1 SV=1" "0.054" "False" "1.261" "1" "1" "1" "1" "1058" "119.4" "8.60" "1.65" "1" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00855, Pf10513, Pf13831, Pf13832" "23774" "ENSG00000100425" "BRD1" "A6ZJA4; hsa:23774; O95696" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "Pathways affected in adenoid cystic carcinoma" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328039708741576867" "False" "Low" "IsMasterProtein" "Q96DT0" "Galectin-12 OS=Homo sapiens OX=9606 GN=LGALS12 PE=1 SV=1" "0.055" "False" "1.255" "4" "1" "1" "1" "336" "37.5" "9.09" "2.49" "1" "signal transduction" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00337" "85329" "ENSG00000133317" "LGALS12" "B2R9N2; G5E970; hsa:85329; Q96DS9; Q96DT0; Q96PR9; Q9H258; Q9H259; Q9NZ02" "" "" "0" "0" "0.949" "0.812" "1.010" "0.937" "0.948" "0.883" "0.851" "0.837" "1.024" "64.2" "61.0" "52.1" "64.8" "60.2" "60.9" "56.7" "54.6" "53.7" "65.8" "" "" "" "" "" "" "" "" "" "" "51.6" "44.0" "41.4" "43.4" "41.6" "45.7" "39.7" "39.9" "53.7" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452075893370782387" "False" "Low" "IsMasterProtein" "Q96Q91" "Anion exchange protein 4 OS=Homo sapiens OX=9606 GN=SLC4A9 PE=2 SV=2" "0.055" "False" "1.254" "2" "1" "1" "1" "983" "108.2" "7.09" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "83697" "ENSG00000113073" "SLC4A9" "B7ZL63; D3DQD4; D3DQD5; D3DQD6; E9PDK1; hsa:83697; Q96Q91; Q96RM5; Q9BXF2; Q9BXN3" "Bicarbonate transporters" "" "1" "0" "0.981" "0.930" "1.202" "0.981" "1.205" "1.259" "0.799" "0.888" "1.133" "34.7" "34.1" "32.3" "41.8" "34.1" "41.9" "43.8" "27.8" "30.9" "39.4" "" "" "" "" "" "" "" "" "" "" "27.9" "24.6" "25.7" "28.0" "23.6" "31.4" "30.6" "20.3" "30.9" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2309270274832232483" "False" "Low" "IsMasterProtein" "Q9UMS6" "Synaptopodin-2 OS=Homo sapiens OX=9606 GN=SYNPO2 PE=1 SV=2" "0.055" "False" "1.253" "1" "1" "1" "1" "1093" "117.4" "8.57" "0.00" "1" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00595" "171024" "ENSG00000172403" "SYNPO2" "B2RWP6; B2Y8J9; C6H0M7; hsa:171024; Q9UK89; Q9UMS6; S5XAM4" "" "" "0" "0" "1.105" "0.949" "1.204" "1.086" "0.851" "1.604" "1.092" "0.816" "1.053" "85.9" "94.9" "81.5" "103.3" "93.2" "73.0" "137.7" "93.8" "70.0" "90.4" "" "" "" "" "" "" "" "" "" "" "69.0" "68.5" "64.7" "69.2" "64.5" "54.8" "96.4" "68.5" "70.0" "73.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6903177144074942272" "False" "Low" "IsMasterProtein" "O43900" "Prickle planar cell polarity protein 3 OS=Homo sapiens OX=9606 GN=PRICKLE3 PE=1 SV=2" "0.055" "False" "1.252" "3" "1" "1" "1" "615" "68.6" "7.88" "2.26" "1" "cell organization and biogenesis" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00412, Pf06297" "4007" "ENSG00000012211" "PRICKLE3" "B7Z8F2; hsa:4007; O43900; O76007; Q53XR5" "" "" "0" "0" "1.021" "0.949" "1.182" "1.077" "0.950" "1.078" "1.097" "0.928" "1.043" "78.8" "80.5" "74.8" "93.2" "84.9" "74.8" "85.0" "86.5" "73.2" "82.2" "" "" "" "" "" "" "" "" "" "" "63.3" "58.1" "59.4" "62.4" "58.7" "56.2" "59.5" "63.1" "73.2" "66.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073332157955076013" "False" "Low" "IsMasterProtein" "P50914" "Large ribosomal subunit protein eL14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4" "0.055" "False" "1.249" "5" "1" "1" "1" "215" "23.4" "10.93" "0.00" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01929" "9045" "ENSG00000188846" "RPL14" "hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2452511729080939995" "False" "Low" "IsMasterProtein" "O95159" "Zinc finger protein-like 1 OS=Homo sapiens OX=9606 GN=ZFPL1 PE=1 SV=2" "0.055" "False" "1.246" "3" "1" "1" "1" "310" "34.1" "8.07" "2.82" "1" "transport;other biological processes" "other membranes;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "7542" "ENSG00000162300" "ZFPL1" "A8K7E9; hsa:7542; O14616; O95159; Q9UID0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7001826016762467306" "False" "Low" "IsMasterProtein" "Q9NYR9" "NF-kappa-B inhibitor-interacting Ras-like protein 2 OS=Homo sapiens OX=9606 GN=NKIRAS2 PE=1 SV=1" "0.056" "False" "1.240" "4" "1" "1" "1" "191" "21.5" "8.05" "2.59" "1" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00071" "28511" "ENSG00000168256" "NKIRAS2" "A6NCZ5; B3KNN0; B4DNM3; hsa:28511; Q6PK52; Q96KC7; Q9NSX1; Q9NYR9" "RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1531480521063430198" "False" "Low" "IsMasterProtein" "Q8IUL8" "Cartilage intermediate layer protein 2 OS=Homo sapiens OX=9606 GN=CILP2 PE=1 SV=2" "0.056" "False" "1.239" "1" "1" "1" "1" "1156" "126.2" "8.22" "0.00" "1" "" "non-structural extracellular" "" "Pf00090, Pf13330, Pf13620, Pf13927" "148113" "ENSG00000160161" "CILP2" "hsa:148113; Q6NV88; Q8IUL8; Q8N4A6; Q8WV21" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075637176054845707" "False" "Low" "IsMasterProtein" "Q5TF21" "Microtubule cross-linking factor 3 OS=Homo sapiens OX=9606 GN=MTCL3 PE=1 SV=1" "0.056" "False" "1.234" "1" "1" "1" "1" "947" "103.1" "6.06" "2.47" "1" "other biological processes" "non-structural extracellular;other membranes" "" "Pf11365" "" "ENSG00000214338" "MTCL3" "Q5TF21" "" "" "0" "0" "0.920" "0.970" "1.127" "0.986" "0.971" "1.054" "0.984" "1.008" "1.030" "121.1" "111.4" "117.4" "136.4" "119.4" "117.6" "127.6" "119.2" "122.0" "124.7" "" "" "" "" "" "" "" "" "" "" "97.2" "80.4" "93.2" "91.4" "82.6" "88.2" "89.3" "87.0" "122.0" "101.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269651725271298861" "False" "Low" "IsMasterProtein" "P02751" "Fibronectin OS=Homo sapiens OX=9606 GN=FN1 PE=1 SV=5" "0.057" "True" "1.233" "0" "1" "1" "1" "2477" "272.2" "5.50" "0.00" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00039, Pf00040, Pf00041" "2335" "ENSG00000115414" "FN1" "B7ZLF0; E9PE77; E9PG29; hsa:2335; O95609; O95610; P02751; Q14312; Q14325; Q14326; Q17RV7; Q53S27; Q564H7; Q585T2; Q59EH1; Q60FE4; Q68DP8; Q68DP9; Q68DT4; Q6LDP6; Q6MZS0; Q6MZU5; Q6N025; Q6N0A6; Q7Z391; Q86T27; Q8IVI8; Q96KP7; Q96KP8; Q96KP9; Q9H1B8; Q9HAP3; Q9UMK2" "Cell surface interactions at the vascular wall; Degradation of the extracellular matrix; Integrin cell surface interactions; ECM proteoglycans; GPER1 signaling; Platelet degranulation ; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; MET activates PTK2 signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Molecules associated with elastic fibres; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Fibronectin matrix formation" "Mammary gland development pathway - Puberty (Stage 2 of 4); miRNA targets in ECM and membrane receptors; Focal adhesion; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; Physico-chemical features and toxicity-associated pathways; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Inflammatory response pathway; Small cell lung cancer; IL-18 signaling pathway; Burn wound healing; Pleural mesothelioma; CCL18 signaling pathway; Regulation of actin cytoskeleton; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map" "51" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682566645413249392" "False" "Low" "IsMasterProtein" "Q96AE7" "Tetratricopeptide repeat protein 17 OS=Homo sapiens OX=9606 GN=TTC17 PE=1 SV=1" "0.057" "False" "1.233" "1" "1" "1" "1" "1141" "129.5" "6.58" "0.00" "1" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf13181" "55761" "ENSG00000052841" "TTC17" "G3XAB3; hsa:55761; Q8NEC0; Q96AE7" "" "" "0" "0" "1.032" "1.033" "0.955" "0.938" "0.826" "0.800" "0.916" "0.942" "0.987" "46.8" "48.3" "48.4" "44.7" "43.9" "38.7" "37.5" "42.9" "44.1" "46.2" "" "" "" "" "" "" "" "" "" "" "37.6" "34.9" "38.4" "30.0" "30.4" "29.0" "26.2" "31.3" "44.1" "37.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7130295258021411735" "False" "Low" "IsMasterProtein" "P09848" "Lactase/phlorizin hydrolase OS=Homo sapiens OX=9606 GN=LCT PE=1 SV=3" "0.057" "False" "1.231" "0" "1" "1" "1" "1927" "218.5" "6.34" "0.00" "1" "other metabolic processes" "plasma membrane;other membranes" "other molecular function" "Pf00232" "3938" "ENSG00000115850" "LCT" "hsa:3938; P09848; Q4ZG58" "Digestion of dietary carbohydrate; Intestinal saccharidase deficiencies" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294040977581567700" "False" "Low" "IsMasterProtein" "Q9HBF4" "Zinc finger FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFYVE1 PE=1 SV=1" "0.057" "False" "1.229" "1" "1" "1" "1" "777" "87.1" "7.42" "2.15" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "53349" "ENSG00000165861" "ZFYVE1" "hsa:53349; J3KNL9; Q8WYX7; Q96K57; Q9BXP9; Q9HBF4; Q9HCI3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3711738711712125142" "False" "Low" "IsMasterProtein" "A6NJ88" "Putative SAGE1-like protein OS=Homo sapiens OX=9606 GN=SAGE2P PE=5 SV=4" "0.057" "False" "1.229" "2" "1" "1" "1" "616" "69.0" "6.05" "1.75" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf15300" "" "" "SAGE2P" "A6NJ88" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7254766562605531244" "False" "Low" "IsMasterProtein" "P62324" "Protein BTG1 OS=Homo sapiens OX=9606 GN=BTG1 PE=1 SV=1" "0.057" "False" "1.229" "4" "1" "1" "1" "171" "19.2" "8.18" "2.54" "1" "cell cycle OR cell proliferation;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07742" "694" "ENSG00000133639" "BTG1" "hsa:694; P31607; P62324" "FOXO-mediated transcription of cell cycle genes" "Exercise-induced circadian regulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8244931832406879896" "False" "Low" "IsMasterProtein" "P78424" "POU domain, class 6, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU6F2 PE=1 SV=3" "0.057" "False" "1.225" "1" "1" "1" "1" "691" "73.2" "7.77" "1.93" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "11281" "ENSG00000106536" "POU6F2" "A4D1W2; C4AMB9; hsa:11281; P78424; P78425; Q75ME8; Q86UM6; Q9UDS7" "" "" "0" "0" "0.820" "0.705" "0.911" "0.871" "0.943" "0.913" "0.765" "0.792" "0.757" "53.5" "43.9" "37.7" "48.7" "46.6" "50.4" "48.9" "40.9" "42.4" "40.5" "" "" "" "" "" "" "" "" "" "" "43.0" "31.7" "30.0" "32.6" "32.2" "37.9" "34.2" "29.9" "42.4" "32.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8073063858640932961" "False" "Low" "IsMasterProtein" "Q96BZ9" "TBC1 domain family member 20 OS=Homo sapiens OX=9606 GN=TBC1D20 PE=1 SV=1" "0.058" "False" "1.221" "2" "1" "1" "1" "403" "45.8" "6.86" "1.61" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus" "enzyme regulator activity;other molecular function" "Pf00566" "128637" "ENSG00000125875" "TBC1D20" "A8K6I3; B9A6M1; hsa:128637; Q5JWQ7; Q6ZSY8; Q96BZ9; Q96NE1; Q9BYM7; Q9H140" "COPII-mediated vesicle transport; TBC/RABGAPs" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5509725452834477893" "False" "Low" "IsMasterProtein" "Q96DU3" "SLAM family member 6 OS=Homo sapiens OX=9606 GN=SLAMF6 PE=1 SV=3" "0.058" "False" "1.221" "3" "1" "1" "1" "332" "37.3" "6.79" "1.66" "1" "stress response;other biological processes" "plasma membrane;other membranes" "" "Pf07686" "114836" "ENSG00000162739" "SLAMF6" "A6NMW2; B2R8X8; hsa:114836; Q14CF0; Q5TAS4; Q5TAS6; Q5TAT3; Q96DU3; Q96DV0" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2289092741703597544" "False" "Low" "IsMasterProtein" "Q96JG9" "Zinc finger protein 469 OS=Homo sapiens OX=9606 GN=ZNF469 PE=1 SV=4" "0.058" "False" "1.219" "0" "1" "1" "1" "3953" "413.0" "7.93" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "" "ENSG00000225614" "ZNF469" "H3BS19; Q96JG9" "" "" "0" "0" "1.034" "0.955" "0.914" "1.079" "0.944" "0.919" "1.303" "1.153" "1.021" "65.9" "68.1" "62.9" "60.2" "71.1" "62.2" "60.6" "85.9" "75.9" "67.3" "" "" "" "" "" "" "" "" "" "" "52.9" "49.1" "50.0" "40.4" "49.2" "46.7" "42.4" "62.7" "75.9" "54.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2290634973285225426" "False" "Low" "IsMasterProtein" "Q7Z589" "BRCA2-interacting transcriptional repressor EMSY OS=Homo sapiens OX=9606 GN=EMSY PE=1 SV=2" "0.058" "False" "1.219" "1" "1" "1" "1" "1322" "141.4" "9.33" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf03735" "56946" "ENSG00000158636" "EMSY" "B7ZKT8; B7ZKU0; B7ZKU2; hsa:56946; Q17RM7; Q4G109; Q7Z589; Q8NBU6; Q8TE50; Q9H8I9; Q9NRH0" "" "Mesodermal commitment pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258523794093971664" "False" "Low" "IsMasterProtein" "Q9H310" "Ammonium transporter Rh type B OS=Homo sapiens OX=9606 GN=RHBG PE=1 SV=3" "0.058" "False" "1.218" "5" "1" "1" "1" "458" "49.4" "6.89" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton" "transporter activity;cytoskeletal activity" "Pf00909" "57127" "ENSG00000132677" "RHBG" "A8K475; hsa:57127; Q5SZW4; Q5SZW6; Q5SZW7; Q6P193; Q6YJI2; Q6YJI3; Q9H310" "Rhesus glycoproteins mediate ammonium transport." "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344145202623347770" "False" "Low" "IsMasterProtein" "O60637" "Tetraspanin-3 OS=Homo sapiens OX=9606 GN=TSPAN3 PE=1 SV=1" "0.058" "False" "1.218" "3" "1" "1" "1" "253" "28.0" "5.81" "2.21" "1" "" "other membranes" "" "Pf00335" "10099" "ENSG00000140391" "TSPAN3" "A6NEH4; B3KQQ2; B4DP19; hsa:10099; O60637; Q9BW22; Q9NVX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373985546304769447" "False" "Low" "IsMasterProtein" "A6NJT0" "Homeobox protein unc-4 homolog OS=Homo sapiens OX=9606 GN=UNCX PE=1 SV=1" "0.058" "False" "1.216" "1" "1" "1" "1" "531" "53.7" "7.20" "2.54" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "340260" "ENSG00000164853" "UNCX" "A4D221; A6NJT0; hsa:340260" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-419593273491942870" "False" "Low" "IsMasterProtein" "P0C7P3" "Protein SLFN14 OS=Homo sapiens OX=9606 GN=SLFN14 PE=1 SV=2" "0.058" "False" "1.216" "1" "1" "1" "1" "912" "103.8" "8.24" "1.97" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04326, Pf17057, Pf21026" "342618" "ENSG00000236320" "SLFN14" "B2RTW9; hsa:342618; P0C7P3" "" "17q12 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850539477477938049" "False" "Low" "IsMasterProtein" "Q9Y2J8" "Protein-arginine deiminase type-2 OS=Homo sapiens OX=9606 GN=PADI2 PE=1 SV=2" "0.059" "False" "1.213" "3" "1" "1" "1" "665" "75.5" "5.59" "2.57" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03068, Pf08526, Pf08527" "11240" "ENSG00000117115; ENSG00000291387" "PADI2" "hsa:11240; Q96DA7; Q9UPN2; Q9Y2J8" "Neutrophil degranulation; Chromatin modifying enzymes" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6012627843856411618" "False" "Low" "IsMasterProtein" "A6NKG5" "Retrotransposon-like protein 1 OS=Homo sapiens OX=9606 GN=RTL1 PE=1 SV=3" "0.059" "False" "1.213" "1" "1" "1" "1" "1358" "155.0" "5.21" "2.54" "1" "" "other membranes" "" "Pf16297, Pf17919" "388015" "ENSG00000254656" "RTL1" "A6NKG5; E9PKS8; hsa:388015" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2669565184657084556" "False" "Low" "IsMasterProtein" "Q0VDD5" "Putative uncharacterized protein encoded by MIR22HG OS=Homo sapiens OX=9606 GN=MIR22HG PE=5 SV=1" "0.059" "False" "1.210" "14" "1" "1" "1" "57" "6.5" "11.21" "2.87" "1" "" "" "" "" "" "" "MIR22HG" "Q0VDD5; Q0VDD6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397019558410354767" "False" "Low" "IsMasterProtein" "Q6EMB2" "Tubulin polyglutamylase TTLL5 OS=Homo sapiens OX=9606 GN=TTLL5 PE=1 SV=3" "0.060" "False" "1.209" "1" "1" "1" "1" "1281" "143.5" "8.63" "2.60" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23093" "ENSG00000119685" "TTLL5" "B9EGH8; B9EGH9; hsa:23093; Q6EMB2; Q9BUB0; Q9H0G4; Q9H7W2; Q9P1V5; Q9UPZ4" "Carboxyterminal post-translational modifications of tubulin" "Ciliopathies" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8909077436682451150" "False" "Low" "IsMasterProtein" "Q9UPP2" "IQ motif and SEC7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=IQSEC3 PE=1 SV=3" "0.060" "False" "1.208" "1" "1" "1" "1" "1182" "127.5" "6.51" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01369, Pf16453" "440073" "ENSG00000120645; ENSG00000262607" "IQSEC3" "A6NIF2; A6NKV9; hsa:440073; Q8TB43; Q9UPP2" "NPAS4 regulates expression of target genes" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7792324858940339683" "False" "Low" "IsMasterProtein" "Q5THJ4" "Intermembrane lipid transfer protein VPS13D OS=Homo sapiens OX=9606 GN=VPS13D PE=1 SV=2" "0.060" "False" "1.208" "0" "1" "1" "1" "4388" "491.6" "6.58" "2.15" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes" "" "Pf00627, Pf06650, Pf12624, Pf16908, Pf16909, Pf16910" "55187" "ENSG00000048707" "VPS13D" "hsa:55187; J3KP14; Q58F10; Q5THJ4; Q6MZK9; Q6ZV12; Q709C4; Q709C5; Q86UB4; Q9NSJ3; Q9UIM0" "" "" "0" "0" "0.660" "0.860" "0.946" "0.959" "0.787" "0.936" "0.862" "0.873" "1.309" "52.3" "34.5" "45.0" "49.5" "50.2" "41.2" "49.0" "45.1" "45.7" "68.5" "" "" "" "" "" "" "" "" "" "" "42.0" "24.9" "35.7" "33.2" "34.7" "30.9" "34.3" "32.9" "45.7" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577804302034964340" "False" "Low" "IsMasterProtein" "Q8NHX9" "Two pore channel protein 2 OS=Homo sapiens OX=9606 GN=TPCN2 PE=1 SV=2" "0.060" "False" "1.207" "2" "1" "1" "1" "752" "85.2" "7.09" "2.12" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf00520" "219931" "ENSG00000162341" "TPCN2" "hsa:219931; Q8NHX9; Q9NT82" "Stimuli-sensing channels" "VEGFA-VEGFR2 signaling; Ebola virus infection in host" "3" "0" "0.861" "0.746" "0.775" "0.526" "0.740" "0.548" "0.292" "0.572" "0.624" "156.5" "134.8" "116.7" "121.3" "82.3" "115.8" "85.8" "45.7" "89.5" "97.7" "" "" "" "" "" "" "" "" "" "" "125.7" "97.3" "92.7" "81.3" "56.9" "86.9" "60.1" "33.4" "89.5" "79.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2569459131829985106" "False" "Low" "IsMasterProtein" "Q8TAC1" "Rieske domain-containing protein OS=Homo sapiens OX=9606 GN=RFESD PE=1 SV=1" "0.060" "False" "1.206" "6" "1" "1" "1" "157" "17.8" "6.86" "0.00" "1" "" "" "other molecular function" "Pf00355" "317671" "ENSG00000175449" "RFESD" "hsa:317671; J3KPH1; Q8TAC1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "276333743643228989" "False" "Low" "IsMasterProtein" "O95870" "Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=3" "0.060" "False" "1.204" "3" "1" "1" "1" "558" "63.2" "8.13" "0.00" "1" "other metabolic processes" "other membranes" "other molecular function" "Pf00561" "7920" "ENSG00000204427; ENSG00000206403; ENSG00000224552; ENSG00000230475; ENSG00000231488; ENSG00000235676; ENSG00000236063" "ABHD16A" "A2BEY3; B7Z4R6; hsa:7920; O95870; Q5SRR1; Q5SRR2; Q8WYH0; Q9NW33" "" "IL-18 signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477326506537257431" "False" "Low" "IsMasterProtein" "Q5TGJ6" "Hepatoma-derived growth factor-like protein 1 OS=Homo sapiens OX=9606 GN=HDGFL1 PE=1 SV=1" "0.060" "False" "1.203" "3" "1" "1" "1" "251" "27.2" "4.56" "0.00" "1" "cell organization and biogenesis" "nucleus" "" "Pf00855" "154150" "ENSG00000112273" "HDGFL1" "hsa:154150; Q5TGJ6; Q96MJ6" "" "" "0" "0" "1.068" "1.016" "0.880" "1.021" "1.167" "1.090" "1.131" "1.042" "1.032" "156.1" "166.8" "158.6" "137.3" "159.4" "182.3" "170.3" "176.5" "162.7" "161.1" "" "" "" "" "" "" "" "" "" "" "125.4" "120.4" "126.0" "92.0" "110.2" "136.8" "119.2" "128.9" "162.7" "131.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812435587669983300" "False" "Low" "IsMasterProtein" "Q17RC7" "Exocyst complex component 3-like protein 4 OS=Homo sapiens OX=9606 GN=EXOC3L4 PE=1 SV=2" "0.060" "False" "1.203" "1" "1" "1" "1" "722" "79.8" "6.32" "0.00" "1" "transport;other biological processes" "other cell component" "other molecular function" "Pf06046" "91828" "ENSG00000205436" "EXOC3L4" "hsa:91828; Q14CR2; Q17RC7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3120416085995135144" "False" "Low" "IsMasterProtein" "Q8N961" "Ankyrin repeat and BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ABTB2 PE=1 SV=2" "0.061" "False" "1.198" "1" "1" "1" "1" "1025" "113.6" "6.29" "0.00" "1" "other biological processes" "" "other molecular function" "Pf00651, Pf12796" "25841" "ENSG00000166016" "ABTB2" "A8K6S9; E9PRW7; hsa:25841; Q52LD6; Q6MZW4; Q8N961; Q8NB44" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7296752433010816253" "False" "Low" "IsMasterProtein" "Q5T4F4" "Protrudin OS=Homo sapiens OX=9606 GN=ZFYVE27 PE=1 SV=1" "0.061" "False" "1.197" "3" "1" "1" "1" "411" "45.8" "5.15" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "118813" "ENSG00000155256" "ZFYVE27" "B7Z3S0; B7Z404; B7Z626; G8JLC3; G8JLF0; hsa:118813; J3KP98; Q5T4F1; Q5T4F2; Q5T4F3; Q5T4F4; Q8N1K0; Q8N6D6; Q8NCA0; Q8NDE4; Q96M08" "" "" "0" "0" "1.223" "0.983" "1.507" "1.579" "1.093" "1.152" "1.151" "1.528" "0.990" "10.9" "13.3" "10.7" "16.4" "17.2" "11.9" "12.5" "12.5" "16.6" "10.8" "" "" "" "" "" "" "" "" "" "" "8.7" "9.6" "8.5" "11.0" "11.9" "8.9" "8.8" "9.1" "16.6" "8.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8152451809479341191" "False" "Low" "IsMasterProtein" "A4UGR9" "Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2" "0.061" "False" "1.196" "0" "1" "1" "1" "3374" "382.1" "6.38" "0.00" "1" "cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf08043" "129446" "ENSG00000163092" "XIRP2" "A0PJ94; A4UGR9; B2BBS0; B2BBS1; B2BBS4; B3KVH0; hsa:129446; J3KNB1; Q53R52; Q5MJ67; Q702N7; Q86T36; Q86T38; Q86T46; Q86T51; Q86T53; Q86T55; Q86T79; Q86TB6; Q8N1M9; Q8N3R5; Q8TBV6" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135742112230704380" "False" "Low" "IsMasterProtein" "Q92791" "Endoplasmic reticulum protein SC65 OS=Homo sapiens OX=9606 GN=P3H4 PE=1 SV=1" "0.061" "False" "1.196" "4" "1" "1" "1" "437" "50.3" "4.77" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "" "10609" "ENSG00000141696" "P3H4" "hsa:10609; Q53GI6; Q92791; Q9H4F6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5881151857226110345" "False" "Low" "IsMasterProtein" "Q8WVS4" "Cytoplasmic dynein 2 intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC2I1 PE=1 SV=3" "0.061" "False" "1.193" "1" "1" "1" "1" "1066" "122.5" "7.31" "1.75" "1" "cell organization and biogenesis;transport;developmental processes" "cytoskeleton;other cell component" "other molecular function" "" "55112" "ENSG00000126870" "DYNC2I1" "hsa:55112; Q8WVS4; Q9NW58" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 3q29 copy number variation syndrome; Bardet-Biedl syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3835661040312072050" "False" "Low" "IsMasterProtein" "Q9BUA3" "Spindlin interactor and repressor of chromatin-binding protein OS=Homo sapiens OX=9606 GN=SPINDOC PE=1 SV=3" "0.061" "False" "1.193" "2" "1" "1" "1" "381" "41.0" "5.01" "3.20" "1" "stress response;other biological processes" "nucleus;other cell component" "" "Pf18658" "144097" "ENSG00000168005" "SPINDOC" "hsa:144097; Q68CV7; Q6PHS2; Q96IH0; Q9BUA3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6224578452559730793" "False" "Low" "IsMasterProtein" "Q9H116" "GDNF-inducible zinc finger protein 1 OS=Homo sapiens OX=9606 GN=GZF1 PE=1 SV=1" "0.062" "False" "1.192" "1" "1" "1" "1" "711" "80.4" "7.87" "0.00" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf13912" "64412" "ENSG00000125812" "GZF1" "A8K199; B2RBC3; B3KPL4; B4DF58; D3DW39; hsa:64412; Q54A22; Q96N08; Q9BQK9; Q9H116; Q9H117; Q9H6W6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8395516417876172321" "False" "Low" "IsMasterProtein" "P55089" "Urocortin OS=Homo sapiens OX=9606 GN=UCN PE=1 SV=1" "0.062" "False" "1.190" "6" "1" "1" "1" "124" "13.5" "11.71" "1.85" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00473" "7349" "ENSG00000163794" "UCN" "hsa:7349; P55089; Q6FG64" "Class B/2 (Secretin family receptors); Synthesis, secretion, and deacylation of Ghrelin" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8553170675467800844" "False" "Low" "IsMasterProtein" "Q6UXU4" "Germ cell-specific gene 1-like protein OS=Homo sapiens OX=9606 GN=GSG1L PE=1 SV=2" "0.062" "False" "1.190" "3" "1" "1" "1" "331" "36.8" "7.05" "0.00" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf07803" "146395" "ENSG00000169181" "GSG1L" "hsa:146395; Q6UXU4; Q7Z6F8; Q8TB81" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4977571995799431172" "False" "Low" "IsMasterProtein" "P17947" "Transcription factor PU.1 OS=Homo sapiens OX=9606 GN=SPI1 PE=1 SV=2" "0.063" "False" "1.184" "4" "1" "1" "1" "270" "31.1" "6.80" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "6688" "ENSG00000066336" "SPI1" "hsa:6688; P17947" "Transcriptional regulation of granulopoiesis; RUNX1 regulates transcription of genes involved in differentiation of HSCs" "RANKL/RANK signaling pathway; Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets; ApoE and miR-146 in inflammation and atherosclerosis; Prion disease pathway; Acute myeloid leukemia; Type II interferon signaling" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4969818127362219692" "False" "Low" "IsMasterProtein" "Q9H0R1" "AP-5 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP5M1 PE=1 SV=2" "0.064" "False" "1.179" "1" "1" "1" "1" "490" "54.7" "6.61" "2.55" "1" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf00928" "55745" "ENSG00000053770" "AP5M1" "hsa:55745; O95354; Q6ZMD7; Q96DX3; Q9H0R1; Q9NVC5" "" "" "0" "0" "1.066" "0.821" "1.050" "1.065" "0.822" "1.024" "0.878" "1.087" "0.827" "32.9" "35.0" "27.0" "34.5" "35.0" "27.0" "33.7" "28.9" "35.7" "27.2" "" "" "" "" "" "" "" "" "" "" "26.4" "25.3" "21.4" "23.1" "24.2" "20.3" "23.6" "21.1" "35.7" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6129468958153981071" "False" "Low" "IsMasterProtein" "Q1L5Z9" "LON peptidase N-terminal domain and RING finger protein 2 OS=Homo sapiens OX=9606 GN=LONRF2 PE=1 SV=3" "0.064" "False" "1.179" "2" "1" "1" "1" "754" "83.6" "5.90" "0.00" "1" "" "other cell component" "other molecular function" "Pf02190, Pf13923" "164832" "ENSG00000170500" "LONRF2" "B9A006; hsa:164832; Q1L5Z9; Q6ZSR4" "" "" "0" "0" "1.023" "0.970" "1.020" "0.992" "1.023" "1.040" "0.952" "0.925" "0.894" "125.0" "127.8" "121.2" "127.4" "124.0" "127.9" "130.0" "118.9" "115.6" "111.7" "" "" "" "" "" "" "" "" "" "" "100.4" "92.2" "96.3" "85.4" "85.8" "95.9" "91.0" "86.8" "115.6" "90.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364934652316773235" "False" "Low" "IsMasterProtein" "Q96K83" "Zinc finger protein 521 OS=Homo sapiens OX=9606 GN=ZNF521 PE=1 SV=1" "0.065" "False" "1.177" "1" "1" "1" "1" "1311" "147.8" "7.01" "1.74" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf13912" "25925" "ENSG00000198795" "ZNF521" "A3QVP7; B0YJB7; hsa:25925; Q8IXI0; Q8TES6; Q96K83; Q9C065; Q9HAL5; Q9UFK4" "Formation of the anterior neural plate; Formation of the posterior neural plate; RUNX2 regulates osteoblast differentiation" "" "3" "0" "1.050" "0.936" "1.237" "1.254" "1.103" "1.190" "0.955" "1.312" "1.193" "92.7" "97.3" "86.7" "114.6" "116.2" "102.2" "110.2" "88.4" "121.6" "110.5" "" "" "" "" "" "" "" "" "" "" "74.4" "70.2" "68.9" "76.8" "80.4" "76.7" "77.2" "64.6" "121.6" "89.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562865633483991782" "False" "Low" "IsMasterProtein" "Q9UBT7" "Alpha-catulin OS=Homo sapiens OX=9606 GN=CTNNAL1 PE=1 SV=2" "0.065" "False" "1.176" "1" "1" "1" "1" "734" "81.8" "6.64" "2.76" "1" "cell adhesion;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf01044" "8727" "ENSG00000119326" "CTNNAL1" "B5BU47; hsa:8727; O76084; Q53FQ2; Q5JTQ7; Q5JTQ8; Q9UBT7; Q9Y401" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753373290981074159" "False" "Low" "IsMasterProtein" "Q8IXI1" "Mitochondrial Rho GTPase 2 OS=Homo sapiens OX=9606 GN=RHOT2 PE=1 SV=2" "0.065" "False" "1.173" "1" "1" "1" "1" "618" "68.1" "5.86" "1.64" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00071, Pf08355, Pf08356" "89941" "ENSG00000140983" "RHOT2" "A2IDC2; hsa:89941; Q8IXI1; Q8NF53; Q96C13; Q96S17; Q9BT60; Q9H7M8" "RHOT2 GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-974411320979070510" "False" "Low" "IsMasterProtein" "Q9P2H0" "Centrosomal protein of 126 kDa OS=Homo sapiens OX=9606 GN=CEP126 PE=1 SV=4" "0.065" "False" "1.173" "1" "1" "1" "1" "1117" "125.8" "8.73" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf15352" "57562" "ENSG00000110318" "CEP126" "hsa:57562; Q4G0U6; Q9P2H0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5202989466020323803" "False" "Low" "IsMasterProtein" "Q9NZW4" "Dentin sialophosphoprotein OS=Homo sapiens OX=9606 GN=DSPP PE=1 SV=2" "0.066" "False" "1.170" "1" "1" "1" "1" "1301" "131.1" "3.87" "0.00" "1" "other biological processes" "non-structural extracellular;extracellular matrix;nucleus;other cell component" "extracellular structural activity;other molecular function" "" "1834" "ENSG00000152591" "DSPP" "A8MUI0; hsa:1834; O95815; Q9NZW4" "ECM proteoglycans" "OSX and miRNAs in tooth development" "2" "0" "1.029" "0.793" "2.053" "1.494" "0.559" "1.506" "1.220" "0.845" "0.940" "30.3" "31.1" "24.0" "62.1" "45.2" "16.9" "45.5" "36.9" "25.5" "28.4" "" "" "" "" "" "" "" "" "" "" "24.3" "22.5" "19.0" "41.6" "31.3" "12.7" "31.9" "27.0" "25.5" "23.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7578021375157339380" "False" "Low" "IsMasterProtein" "Q96N64" "PWWP domain-containing protein 2A OS=Homo sapiens OX=9606 GN=PWWP2A PE=1 SV=2" "0.066" "False" "1.170" "1" "1" "1" "1" "755" "81.9" "9.00" "2.50" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00855" "114825" "ENSG00000170234" "PWWP2A" "G5EA07; hsa:114825; Q2HJJ2; Q8IYR3; Q96N64; Q96PV3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-21239567639981216" "False" "Low" "IsMasterProtein" "Q9BRA0" "N-alpha-acetyltransferase 38, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA38 PE=1 SV=1" "0.066" "False" "1.169" "7" "1" "2" "1" "125" "13.5" "5.53" "1.73" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "84316" "ENSG00000183011" "NAA38" "hsa:84316; Q8N4M0; Q9BRA0" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1025650661191394909" "False" "Low" "IsMasterProtein" "P29474" "Nitric oxide synthase 3 OS=Homo sapiens OX=9606 GN=NOS3 PE=1 SV=4" "0.066" "False" "1.168" "1" "1" "1" "1" "1203" "133.2" "7.27" "3.12" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00175, Pf00258, Pf00667, Pf02898" "4846" "ENSG00000164867" "NOS3" "A0S0A7; A0S0A8; A8KA63; B2RCQ1; E9PFR2; hsa:4846; P29474; Q13662; Q14251; Q14434; Q548C1; Q6GSL5; Q9UDC6" "Extra-nuclear estrogen signaling; NOSTRIN mediated eNOS trafficking; ROS and RNS production in phagocytes; VEGFR2 mediated vascular permeability; Nitric oxide stimulates guanylate cyclase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; NOSIP mediated eNOS trafficking" "Angiogenesis; Effects of nitric oxide; Leptin signaling pathway; Endothelin pathways; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; NO/cGMP/PKG mediated neuroprotection; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Male infertility; Aspirin and miRNAs; Nitric oxide metabolism in cystic fibrosis; RAS and bradykinin pathways in COVID-19; Orexin receptor pathway; Sildenafil treatment; Female steroid hormones in cardiomyocyte energy metabolism; ACE inhibitor pathway" "29" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-328285141880071438" "False" "Low" "IsMasterProtein" "Q9NX57" "Ras-related protein Rab-20 OS=Homo sapiens OX=9606 GN=RAB20 PE=1 SV=1" "0.066" "False" "1.168" "5" "1" "1" "1" "234" "26.3" "6.55" "0.00" "1" "cell organization and biogenesis;stress response;transport" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "55647" "ENSG00000139832" "RAB20" "hsa:55647; Q5T9X5; Q9NX49; Q9NX57" "RAB geranylgeranylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "High" "Not Found" "High" "High" "Not Found" "High" "High" "1" "" "5281776846050101682" "False" "Low" "IsMasterProtein" "Q8N4E4" "Phosducin-like protein 2 OS=Homo sapiens OX=9606 GN=PDCL2 PE=1 SV=2" "0.066" "False" "1.167" "7" "1" "1" "1" "241" "28.1" "4.87" "0.00" "1" "protein metabolism;other metabolic processes" "other cell component" "" "Pf02114" "132954" "ENSG00000163440" "PDCL2" "A8MWA2; B9ZVQ9; hsa:132954; Q8N4E4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "1072346070458958756" "False" "Low" "IsMasterProtein" "Q8N2H3" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PYROXD2 PE=1 SV=2" "0.066" "False" "1.167" "1" "1" "1" "1" "581" "63.0" "6.95" "2.19" "1" "cell organization and biogenesis" "mitochondrion" "other molecular function" "Pf01593, Pf13450" "84795" "ENSG00000119943" "PYROXD2" "D3DR61; hsa:84795; Q5TAA9; Q8N2H3; Q9BRQ1" "" "" "0" "0" "0.942" "0.992" "1.135" "1.137" "1.153" "1.179" "1.161" "1.348" "1.204" "83.0" "78.1" "82.3" "94.2" "94.3" "95.7" "97.8" "96.3" "111.8" "99.9" "" "" "" "" "" "" "" "" "" "" "66.6" "56.4" "65.4" "63.1" "65.2" "71.8" "68.5" "70.3" "111.8" "81.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2264663801536355133" "False" "Low" "IsMasterProtein" "Q6ZS30" "Neurobeachin-like protein 1 OS=Homo sapiens OX=9606 GN=NBEAL1 PE=1 SV=3" "0.066" "False" "1.167" "0" "1" "1" "1" "2694" "307.0" "6.44" "1.87" "1" "other biological processes" "other membranes;cytosol" "other molecular function" "Pf02138, Pf14844, Pf15787, Pf16057, Pf20426" "65065" "ENSG00000144426" "NBEAL1" "A6NHD5; hsa:65065; Q6Y876; Q6ZP36; Q6ZQY5; Q6ZS30; Q8N8R4; Q96Q30; Q96Q31" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099324451451245677" "False" "Low" "IsMasterProtein" "Q56VL3" "OCIA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=OCIAD2 PE=1 SV=1" "0.066" "False" "1.167" "6" "1" "1" "1" "154" "16.9" "9.03" "0.00" "1" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "132299" "ENSG00000145247" "OCIAD2" "B4DPE7; hsa:132299; Q56VL3; Q8N544" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3949633473824829931" "False" "Low" "IsMasterProtein" "O00408" "cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE2A PE=1 SV=1" "0.066" "False" "1.166" "1" "1" "1" "1" "941" "105.6" "5.41" "2.19" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00233, Pf01590" "5138" "ENSG00000186642" "PDE2A" "B2R646; B3KRV5; E9PGI1; F6W5Z0; hsa:5138; O00408; Q5J791; Q5J792; Q5J793; Q6ZMR1" "G alpha (s) signalling events; cGMP effects" "NO/cGMP/PKG mediated neuroprotection; Phosphodiesterases in neuronal function" "4" "0" "0.892" "0.902" "0.962" "1.043" "1.007" "0.990" "0.986" "1.096" "0.969" "170.0" "151.7" "153.2" "163.5" "177.3" "171.2" "168.2" "167.5" "186.3" "164.8" "" "" "" "" "" "" "" "" "" "" "136.5" "109.4" "121.7" "109.6" "122.6" "128.4" "117.8" "122.3" "186.3" "134.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8329990032118445705" "False" "Low" "IsMasterProtein" "Q9P2F5" "Storkhead-box protein 2 OS=Homo sapiens OX=9606 GN=STOX2 PE=1 SV=2" "0.066" "False" "1.166" "1" "1" "1" "1" "926" "102.6" "8.40" "2.82" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10264" "56977" "ENSG00000173320" "STOX2" "A6H8U4; hsa:56977; Q9NPS8; Q9P2F5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7879323310516705125" "False" "Low" "IsMasterProtein" "Q14517" "Protocadherin Fat 1 OS=Homo sapiens OX=9606 GN=FAT1 PE=1 SV=2" "0.066" "False" "1.165" "0" "1" "1" "1" "4588" "506.0" "5.00" "0.00" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00008, Pf00028, Pf02210" "2195" "ENSG00000083857" "FAT1" "hsa:2195; Q14517" "" "Primary focal segmental glomerulosclerosis (FSGS); Head and neck squamous cell carcinoma" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8803282700975052179" "False" "Low" "IsMasterProtein" "Q8N0Z3" "Spindle and centriole-associated protein 1 OS=Homo sapiens OX=9606 GN=SPICE1 PE=1 SV=1" "0.066" "False" "1.165" "2" "1" "1" "1" "855" "96.2" "7.44" "4.04" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf15678" "152185" "ENSG00000163611" "SPICE1" "D3DN72; hsa:152185; Q8N0Z3; Q8WUX6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8680351067166177196" "False" "Low" "IsMasterProtein" "Q8NBU5" "Outer mitochondrial transmembrane helix translocase OS=Homo sapiens OX=9606 GN=ATAD1 PE=1 SV=1" "0.066" "False" "1.162" "3" "1" "1" "1" "361" "40.7" "6.90" "0.00" "1" "other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00004, Pf17862" "84896" "ENSG00000138138" "ATAD1" "D3DR26; hsa:84896; Q6DKG1; Q6P4B9; Q8N3G1; Q8NBU5; Q8WYR9; Q969Y3" "Class I peroxisomal membrane protein import" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5392809055104241363" "False" "Low" "IsMasterProtein" "Q15166" "Serum paraoxonase/lactonase 3 OS=Homo sapiens OX=9606 GN=PON3 PE=1 SV=3" "0.066" "False" "1.162" "2" "1" "1" "1" "354" "39.6" "5.41" "3.14" "1" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "other molecular function" "Pf01731" "5446" "ENSG00000105852" "PON3" "A4D1H8; hsa:5446; O75855; O76060; Q15166; Q6IRU9; Q8IX97; Q9BZH9" "Atorvastatin ADME; Synthesis of 5-eicosatetraenoic acids" "Phase I biotransformations, non-P450" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7077063667014295684" "False" "Low" "IsMasterProtein" "Q9NYQ8" "Protocadherin Fat 2 OS=Homo sapiens OX=9606 GN=FAT2 PE=1 SV=2" "0.066" "False" "1.161" "0" "1" "1" "1" "4349" "479.0" "5.16" "0.00" "1" "cell adhesion;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00008, Pf00028, Pf02210" "2196" "ENSG00000086570" "FAT2" "hsa:2196; O75091; Q9NSR7; Q9NYQ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700429136047639607" "False" "Low" "IsMasterProtein" "O95475" "Homeobox protein SIX6 OS=Homo sapiens OX=9606 GN=SIX6 PE=1 SV=2" "0.066" "False" "1.159" "6" "1" "1" "1" "246" "27.7" "9.42" "2.29" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf16878" "4990" "ENSG00000184302" "SIX6" "hsa:4990; O95475; Q6NT42; Q9P1X8" "" "Ectoderm differentiation" "1" "0" "0.979" "1.033" "1.084" "1.065" "1.073" "1.094" "1.126" "1.104" "1.067" "95.5" "93.5" "98.7" "103.5" "101.7" "102.5" "104.5" "107.6" "105.4" "101.9" "" "" "" "" "" "" "" "" "" "" "76.7" "67.5" "78.4" "69.4" "70.3" "76.9" "73.2" "78.6" "105.4" "82.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6343792019181961185" "False" "Low" "IsMasterProtein" "Q9H4G4" "Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens OX=9606 GN=GLIPR2 PE=1 SV=3" "0.066" "False" "1.159" "5" "1" "1" "1" "154" "17.2" "9.41" "1.86" "1" "other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "other molecular function" "Pf00188" "152007" "ENSG00000122694" "GLIPR2" "hsa:152007; Q5VZR1; Q8N2S6; Q8WWC9; Q8WX36; Q9H4G4" "" "" "0" "0" "0.792" "0.896" "0.781" "0.592" "0.664" "0.671" "0.481" "0.586" "0.796" "66.4" "52.6" "59.5" "51.8" "39.3" "44.1" "44.6" "32.0" "38.9" "52.9" "" "" "" "" "" "" "" "" "" "" "53.3" "38.0" "47.3" "34.7" "27.2" "33.1" "31.2" "23.3" "38.9" "43.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106727462233130038" "False" "Low" "IsMasterProtein" "Q6V0L0" "Cytochrome P450 26C1 OS=Homo sapiens OX=9606 GN=CYP26C1 PE=1 SV=2" "0.066" "False" "1.159" "2" "1" "2" "1" "522" "57.1" "9.00" "3.51" "1" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00067" "340665" "ENSG00000187553" "CYP26C1" "hsa:340665; Q5VXH6; Q6V0L0" "Vitamins; RA biosynthesis pathway; Defective CYP26C1 causes FFDD4" "Oxidation by cytochrome P450; 22q11.2 copy number variation syndrome; Metapathway biotransformation Phase I and II" "6" "0" "1.226" "1.344" "1.092" "1.252" "1.001" "0.697" "0.989" "1.046" "1.205" "70.8" "86.8" "95.1" "77.3" "88.6" "70.9" "49.3" "70.0" "74.0" "85.3" "" "" "" "" "" "" "" "" "" "" "56.8" "62.6" "75.6" "51.8" "61.3" "53.2" "34.5" "51.1" "74.0" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1876819814841640005" "False" "Low" "IsMasterProtein" "Q86UK5" "Limbin OS=Homo sapiens OX=9606 GN=EVC2 PE=1 SV=1" "0.068" "False" "1.155" "1" "1" "1" "1" "1308" "147.9" "6.96" "1.77" "1" "signal transduction" "plasma membrane;other membranes;cytoskeleton;other cell component" "" "Pf12297" "132884" "ENSG00000173040" "EVC2" "hsa:132884; Q86UK5; Q86YT3; Q86YT4; Q8NG49" "Activation of SMO" "Hedgehog signaling pathway; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716082451769412177" "False" "Low" "IsMasterProtein" "Q14494" "Endoplasmic reticulum membrane sensor NFE2L1 OS=Homo sapiens OX=9606 GN=NFE2L1 PE=1 SV=1" "0.068" "False" "1.154" "3" "1" "1" "1" "772" "84.7" "4.64" "0.00" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03131" "4779" "ENSG00000082641" "NFE2L1" "D3DTU3; D3DTU5; hsa:4779; Q12877; Q14494; Q96FN6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7197647763963840920" "False" "Low" "IsMasterProtein" "Q9NVH1" "DnaJ homolog subfamily C member 11 OS=Homo sapiens OX=9606 GN=DNAJC11 PE=1 SV=2" "0.068" "False" "1.153" "1" "1" "1" "1" "559" "63.2" "8.40" "2.76" "1" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf00226, Pf11875" "55735" "ENSG00000007923" "DNAJC11" "hsa:55735; Q4VWF5; Q5VZN0; Q6PK20; Q6PK70; Q8NDM2; Q96CL7; Q9NVH1" "Cristae formation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1933672804306335838" "False" "Low" "IsMasterProtein" "Q07343" "3',5'-cyclic-AMP phosphodiesterase 4B OS=Homo sapiens OX=9606 GN=PDE4B PE=1 SV=1" "0.068" "False" "1.153" "2" "1" "1" "1" "736" "83.3" "5.25" "1.81" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00233, Pf18100" "5142" "ENSG00000184588" "PDE4B" "A5YW33; hsa:5142; O15443; Q07343; Q13945; Q5TEK4; Q5TEK5; Q5TEK6" "" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Phosphodiesterases in neuronal function; Sildenafil treatment" "6" "0" "0.781" "0.862" "0.831" "0.923" "0.973" "0.836" "0.844" "0.947" "0.717" "71.1" "55.5" "61.3" "59.0" "65.6" "69.1" "59.5" "60.0" "67.3" "51.0" "" "" "" "" "" "" "" "" "" "" "57.1" "40.1" "48.7" "39.6" "45.4" "51.9" "41.6" "43.8" "67.3" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "755217233260055713" "False" "Low" "IsMasterProtein" "O95786" "Antiviral innate immune response receptor RIG-I OS=Homo sapiens OX=9606 GN=RIGI PE=1 SV=2" "0.068" "False" "1.153" "2" "1" "1" "1" "925" "106.5" "6.40" "0.00" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf11648, Pf16739, Pf18119" "23586" "ENSG00000107201" "RIGI" "A2RU81; hsa:23586; O95786; Q5HYE1; Q5VYT1; Q9NT04" "RSV-host interactions; Ub-specific processing proteases; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; OAS antiviral response; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "Novel intracellular components of RIG-I-like receptor pathway; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Pathways of nucleic acid metabolism and innate immune sensing; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19" "27" "0" "0.949" "0.850" "1.080" "1.038" "0.953" "0.790" "1.109" "0.918" "1.121" "29.9" "28.4" "25.4" "32.3" "31.1" "28.5" "23.6" "33.2" "27.4" "33.5" "" "" "" "" "" "" "" "" "" "" "24.0" "20.5" "20.2" "21.6" "21.5" "21.4" "16.5" "24.2" "27.4" "27.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990319934283026271" "False" "Low" "IsMasterProtein" "O43741" "5'-AMP-activated protein kinase subunit beta-2 OS=Homo sapiens OX=9606 GN=PRKAB2 PE=1 SV=1" "0.068" "False" "1.151" "4" "1" "1" "1" "272" "30.3" "6.46" "0.00" "1" "other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04739, Pf16561" "5565" "ENSG00000131791" "PRKAB2" "A8K9V5; B4DH06; hsa:5565; O43741; Q5VXY0" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "25" "0" "1.091" "1.080" "1.366" "1.157" "1.318" "1.297" "0.906" "1.056" "1.049" "18.9" "20.6" "20.4" "25.8" "21.9" "24.9" "24.5" "17.1" "20.0" "19.9" "" "" "" "" "" "" "" "" "" "" "15.2" "14.9" "16.2" "17.3" "15.1" "18.7" "17.2" "12.5" "20.0" "16.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7209965094949861737" "False" "Low" "IsMasterProtein" "Q9BRS8" "La-related protein 6 OS=Homo sapiens OX=9606 GN=LARP6 PE=1 SV=1" "0.068" "False" "1.151" "3" "1" "1" "1" "491" "54.7" "8.25" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf05383, Pf12901" "55323" "ENSG00000166173" "LARP6" "hsa:55323; Q5XKE4; Q8N3N2; Q9BRS8; Q9NUR0" "" "" "0" "0" "1.030" "0.992" "1.163" "1.003" "0.906" "1.061" "0.906" "0.698" "0.935" "28.1" "29.0" "27.9" "32.7" "28.2" "25.5" "29.8" "25.5" "19.6" "26.3" "" "" "" "" "" "" "" "" "" "" "22.6" "20.9" "22.2" "21.9" "19.5" "19.1" "20.9" "18.6" "19.6" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3609131082227720096" "False" "Low" "IsMasterProtein" "O15499" "Homeobox protein goosecoid-2 OS=Homo sapiens OX=9606 GN=GSC2 PE=1 SV=1" "0.068" "False" "1.149" "5" "1" "1" "1" "205" "21.5" "10.55" "2.17" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "2928" "ENSG00000063515" "GSC2" "hsa:2928; O15499" "" "22q11.2 copy number variation syndrome" "1" "0" "0.802" "0.814" "1.069" "0.884" "0.964" "0.796" "0.940" "1.119" "0.895" "106.9" "85.8" "87.0" "114.3" "94.5" "103.0" "85.1" "100.6" "119.6" "95.6" "" "" "" "" "" "" "" "" "" "" "85.9" "61.9" "69.1" "76.6" "65.4" "77.3" "59.6" "73.4" "119.6" "77.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1366823694839225379" "False" "Low" "IsMasterProtein" "Q96LY2" "Coiled-coil domain-containing protein 74B OS=Homo sapiens OX=9606 GN=CCDC74B PE=1 SV=1" "0.069" "False" "1.146" "3" "1" "1" "1" "380" "41.8" "10.45" "0.00" "1" "" "" "" "Pf14916, Pf14917" "91409" "ENSG00000152076" "CCDC74B" "hsa:91409; Q6NW18; Q96LY2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4276327742936350895" "False" "Low" "IsMasterProtein" "Q9H582" "Zinc finger protein 644 OS=Homo sapiens OX=9606 GN=ZNF644 PE=1 SV=2" "0.069" "False" "1.144" "1" "1" "1" "1" "1327" "149.5" "8.16" "1.80" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "84146" "ENSG00000122482" "ZNF644" "A2RU71; hsa:84146; Q2TAM0; Q5TCC0; Q6BEP7; Q6P446; Q6PI06; Q7LG67; Q9H582; Q9ULJ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3857205215219748309" "False" "Low" "IsMasterProtein" "Q8N2I9" "Serine/threonine-protein kinase 40 OS=Homo sapiens OX=9606 GN=STK40 PE=1 SV=2" "0.069" "False" "1.142" "3" "1" "1" "1" "435" "49.0" "7.93" "0.00" "1" "other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00069" "83931" "ENSG00000196182" "STK40" "D3DPS8; hsa:83931; Q5VTK8; Q5VTK9; Q6ZMN1; Q8N2I9; Q8N2J8; Q8N3I6; Q96HN6; Q96I44; Q9BSA3; Q9H7H6" "" "IL-18 signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9041443353459398324" "False" "Low" "IsMasterProtein" "Q8N9N7" "Leucine-rich repeat-containing protein 57 OS=Homo sapiens OX=9606 GN=LRRC57 PE=1 SV=1" "0.069" "False" "1.142" "5" "1" "1" "1" "239" "26.7" "8.43" "2.36" "1" "" "other membranes" "" "Pf13855" "255252" "ENSG00000180979" "LRRC57" "hsa:255252; Q7Z2Z6; Q8N1T6; Q8N9N7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5230253163633364857" "False" "Low" "IsMasterProtein" "Q92834" "X-linked retinitis pigmentosa GTPase regulator OS=Homo sapiens OX=9606 GN=RPGR PE=1 SV=2" "0.069" "False" "1.141" "1" "1" "1" "1" "1020" "113.3" "4.86" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00415" "6103" "ENSG00000156313" "RPGR" "B1ARN3; E9PE28; hsa:6103; O00702; O00737; Q3KN84; Q8N5T6; Q92834; Q93039; Q9HD29; Q9UMR1" "" "Ciliary landscape" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2689761144797840992" "False" "Low" "IsMasterProtein" "Q5T8A7" "Protein phosphatase 1 regulatory subunit 26 OS=Homo sapiens OX=9606 GN=PPP1R26 PE=1 SV=1" "0.070" "False" "1.139" "0" "1" "1" "1" "1209" "127.3" "8.59" "2.84" "1" "" "nucleus" "enzyme regulator activity" "Pf15740" "9858" "ENSG00000196422" "PPP1R26" "hsa:9858; Q5T8A7; Q86WU0; Q8WVV0; Q9Y4D3" "" "" "0" "0" "0.794" "1.020" "0.802" "0.870" "0.916" "0.774" "0.802" "0.813" "1.020" "115.0" "91.3" "117.4" "92.2" "100.0" "105.3" "89.0" "92.2" "93.5" "117.3" "" "" "" "" "" "" "" "" "" "" "92.4" "65.9" "93.2" "61.8" "69.2" "79.0" "62.3" "67.4" "93.5" "95.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1183158810236763117" "False" "Low" "IsMasterProtein" "O75564" "Jerky protein homolog OS=Homo sapiens OX=9606 GN=JRK PE=1 SV=3" "0.070" "False" "1.138" "3" "1" "1" "1" "556" "61.8" "7.96" "0.00" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf03184, Pf03221, Pf04218" "8629" "ENSG00000234616" "JRK" "D3DWI5; hsa:8629; O75564; O75565; Q86XJ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8353189008995194781" "False" "Low" "IsMasterProtein" "Q9GZM7" "Tubulointerstitial nephritis antigen-like OS=Homo sapiens OX=9606 GN=TINAGL1 PE=1 SV=1" "0.070" "False" "1.138" "3" "1" "1" "1" "467" "52.4" "6.99" "1.91" "1" "transport" "non-structural extracellular;other cell component" "extracellular structural activity;other molecular function" "Pf00112" "64129" "ENSG00000142910" "TINAGL1" "A8K9Q5; B4DPK6; D3DPN8; hsa:64129; Q8TEJ9; Q8WZ23; Q96GZ4; Q96JW3; Q9GZM7" "" "" "0" "0" "0.869" "0.960" "1.071" "1.262" "1.121" "1.315" "1.382" "1.274" "1.177" "80.0" "69.5" "76.8" "85.6" "100.9" "89.6" "105.2" "110.5" "101.9" "94.1" "" "" "" "" "" "" "" "" "" "" "64.2" "50.2" "61.0" "57.4" "69.8" "67.3" "73.6" "80.7" "101.9" "76.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653073458972591476" "False" "Low" "IsMasterProtein" "O75683" "Surfeit locus protein 6 OS=Homo sapiens OX=9606 GN=SURF6 PE=1 SV=3" "0.071" "False" "1.133" "2" "1" "1" "1" "361" "41.4" "10.64" "2.95" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04935" "6838" "ENSG00000148296; ENSG00000281309" "SURF6" "hsa:6838; O75683; Q5T8U1; Q9BRK9; Q9BTZ5; Q9UK24" "" "" "0" "0" "1.128" "1.174" "1.148" "1.068" "1.247" "1.141" "1.145" "1.162" "1.219" "201.0" "226.6" "236.0" "230.7" "214.6" "250.6" "229.4" "230.0" "233.5" "244.9" "" "" "" "" "" "" "" "" "" "" "161.4" "163.5" "187.5" "154.6" "148.4" "188.0" "160.6" "168.0" "233.5" "199.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6140952741663270084" "False" "Low" "IsMasterProtein" "Q9H3U5" "Lysosomal dipeptide transporter MFSD1 OS=Homo sapiens OX=9606 GN=MFSD1 PE=1 SV=2" "0.071" "False" "1.133" "1" "1" "1" "1" "465" "51.2" "6.74" "2.66" "1" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "transporter activity;other molecular function" "" "64747" "ENSG00000118855" "MFSD1" "B4DGJ8; B4DMR8; B4DU49; B4DWU1; C9JS94; hsa:64747; J3KQL7; Q05C07; Q5XKJ1; Q8IVS1; Q8IXG4; Q9H3U5; Q9H7X1" "" "" "0" "0" "0.785" "0.908" "0.941" "0.802" "0.901" "0.879" "0.729" "0.879" "0.893" "97.7" "76.7" "88.7" "91.9" "78.3" "88.0" "85.8" "71.2" "85.9" "87.3" "" "" "" "" "" "" "" "" "" "" "78.4" "55.3" "70.5" "61.6" "54.2" "66.0" "60.1" "52.0" "85.9" "71.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108956344792868683" "False" "Low" "IsMasterProtein" "P05981" "Serine protease hepsin OS=Homo sapiens OX=9606 GN=HPN PE=1 SV=1" "0.071" "False" "1.129" "3" "1" "1" "1" "417" "45.0" "7.62" "0.00" "1" "cell organization and biogenesis;protein metabolism;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00089, Pf09272" "3249" "ENSG00000105707" "HPN" "B2RDS4; hsa:3249; P05981" "MET Receptor Activation; Signaling by MST1" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "700962882468827525" "False" "Low" "IsMasterProtein" "Q9ULI2" "Beta-citrylglutamate synthase B OS=Homo sapiens OX=9606 GN=RIMKLB PE=1 SV=2" "0.072" "False" "1.127" "2" "1" "1" "1" "386" "42.4" "6.00" "0.00" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf08443" "57494" "ENSG00000166532" "RIMKLB" "B7Z834; D3DUV2; hsa:57494; Q8N4P4; Q8WTW6; Q9ULI2" "Glutamate and glutamine metabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "High" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "2490562156989665946" "False" "Low" "IsMasterProtein" "O75478" "Transcriptional adapter 2-alpha OS=Homo sapiens OX=9606 GN=TADA2A PE=1 SV=3" "0.073" "False" "1.123" "4" "1" "1" "1" "443" "51.5" "6.89" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf04433" "6871" "ENSG00000277104" "TADA2A" "A8MVD0; B3KMU9; hsa:6871; O75478; Q9BVJ0; Q9UCW2; Q9UP49" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8283098890502474545" "False" "Low" "IsMasterProtein" "Q9Y5T4" "DnaJ homolog subfamily C member 15 OS=Homo sapiens OX=9606 GN=DNAJC15 PE=1 SV=2" "0.073" "False" "1.121" "7" "1" "1" "1" "150" "16.4" "10.08" "2.23" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "" "29103" "ENSG00000120675" "DNAJC15" "B2R4L0; hsa:29103; Q5T219; Q6X963; Q9Y5T4" "" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2262521806187627301" "False" "Low" "IsMasterProtein" "Q14995" "Nuclear receptor subfamily 1 group D member 2 OS=Homo sapiens OX=9606 GN=NR1D2 PE=1 SV=4" "0.073" "False" "1.121" "1" "1" "1" "1" "579" "64.6" "7.84" "0.00" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "9975" "ENSG00000174738" "NR1D2" "B2R8Q3; hsa:9975; O00402; Q14995; Q86XD4" "Nuclear Receptor transcription pathway" "Nuclear receptors; Exercise-induced circadian regulation; Clock-controlled autophagy in bone metabolism" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7812634382890342947" "False" "Low" "IsMasterProtein" "Q7Z5P9" "Mucin-19 OS=Homo sapiens OX=9606 GN=MUC19 PE=1 SV=3" "0.074" "False" "1.119" "0" "1" "1" "1" "8384" "804.8" "5.01" "1.83" "1" "" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi" "" "Pf00094, Pf01826, Pf08742" "283463" "" "MUC19" "G3CIG0; hsa:283463; Q7Z5P9; Q8NA85" "Dectin-2 family; Termination of O-glycan biosynthesis; Defective GALNT3 causes HFTC; Defective C1GALT1C1 causes TNPS; Defective GALNT12 causes CRCS1" "" "6" "0" "0.789" "0.886" "1.195" "1.041" "0.952" "1.285" "1.135" "1.030" "1.083" "66.2" "52.2" "58.7" "79.1" "69.0" "63.0" "85.1" "75.2" "68.2" "71.7" "" "" "" "" "" "" "" "" "" "" "53.2" "37.7" "46.6" "53.0" "47.7" "47.3" "59.6" "54.9" "68.2" "58.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5483854635859464991" "False" "Low" "IsMasterProtein" "Q9UKK6" "NTF2-related export protein 1 OS=Homo sapiens OX=9606 GN=NXT1 PE=1 SV=1" "0.074" "False" "1.118" "5" "1" "1" "1" "140" "15.8" "5.03" "2.32" "1" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02136" "29107" "ENSG00000132661" "NXT1" "hsa:29107; Q9UKK6" "Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "1" "0" "0.887" "0.963" "1.027" "0.951" "1.047" "1.016" "0.933" "0.980" "1.012" "144.6" "128.2" "139.2" "148.4" "137.5" "151.3" "146.9" "134.8" "141.6" "146.3" "" "" "" "" "" "" "" "" "" "" "116.1" "92.5" "110.6" "99.4" "95.1" "113.5" "102.8" "98.5" "141.6" "119.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7981637613001176838" "False" "Low" "IsMasterProtein" "Q96JP2" "Unconventional myosin-XVB OS=Homo sapiens OX=9606 GN=MYO15B PE=1 SV=4" "0.074" "False" "1.117" "1" "1" "1" "1" "3096" "338.0" "8.16" "2.01" "1" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00373, Pf00784, Pf07653" "80022" "ENSG00000266714" "MYO15B" "A0A0J9YVZ6; A0A2R8YFM0; hsa:80022; Q96JP2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682194375242126200" "False" "Low" "IsMasterProtein" "P04114" "Apolipoprotein B-100 OS=Homo sapiens OX=9606 GN=APOB PE=1 SV=3" "0.074" "False" "1.117" "0" "1" "1" "1" "4563" "515.2" "7.05" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf01347, Pf06448, Pf09172, Pf12491" "338" "ENSG00000084674" "APOB" "hsa:338; O00502; P04114; P78479; P78480; P78481; Q13779; Q13785; Q13786; Q13787; Q13788; Q4ZG63; Q53QC8; Q7Z600; Q9UMN0" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Cell surface interactions at the vascular wall; Scavenging by Class B Receptors; Regulation of TLR by endogenous ligand; Heme signaling; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; VLDL assembly; VLDL clearance; Scavenging by Class F Receptors; Scavenging by Class H Receptors; Platelet sensitization by LDL; LDL remodeling" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Statin inhibition of cholesterol production; Male infertility; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Familial hyperlipidemia type 2; Cholesterol metabolism; Female steroid hormones in cardiomyocyte energy metabolism; Fatty acids and lipoproteins transport in hepatocytes; Enterocyte cholesterol metabolism" "31" "0" "1.044" "1.073" "1.090" "1.145" "1.131" "1.045" "1.105" "1.127" "1.165" "163.5" "170.7" "175.5" "178.1" "187.1" "184.9" "170.8" "180.6" "184.3" "190.4" "" "" "" "" "" "" "" "" "" "" "131.3" "123.2" "139.4" "119.3" "129.4" "138.7" "119.6" "131.9" "184.3" "154.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7837418014925031231" "False" "Low" "IsMasterProtein" "Q9HB96" "Fanconi anemia group E protein OS=Homo sapiens OX=9606 GN=FANCE PE=1 SV=1" "0.074" "False" "1.115" "1" "1" "1" "1" "536" "58.7" "5.24" "2.06" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytoskeleton;nucleus;other cell component" "" "Pf11510" "2178" "ENSG00000112039" "FANCE" "A8K907; hsa:2178; Q4ZGH2; Q9HB96" "Fanconi Anemia Pathway; PKR-mediated signaling" "DNA repair pathways, full network" "3" "0" "0.978" "0.965" "0.760" "0.739" "0.806" "0.785" "0.967" "0.880" "0.925" "73.5" "71.9" "70.9" "55.9" "54.3" "59.2" "57.7" "71.0" "64.7" "67.9" "" "" "" "" "" "" "" "" "" "" "59.0" "51.9" "56.3" "37.4" "37.5" "44.4" "40.4" "51.9" "64.7" "55.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2682440779883082965" "False" "Low" "IsMasterProtein" "Q9BZV3" "Interphotoreceptor matrix proteoglycan 2 OS=Homo sapiens OX=9606 GN=IMPG2 PE=1 SV=3" "0.074" "False" "1.114" "1" "1" "1" "1" "1241" "138.5" "4.61" "2.81" "1" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;other cell component" "extracellular structural activity;other molecular function" "Pf01390" "50939" "ENSG00000081148" "IMPG2" "A8MWT5; hsa:50939; Q9BZV3; Q9UKD4; Q9UKK5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8076936007263184808" "False" "Low" "IsMasterProtein" "O60662" "Kelch-like protein 41 OS=Homo sapiens OX=9606 GN=KLHL41 PE=1 SV=2" "0.074" "False" "1.112" "1" "1" "1" "1" "606" "68.0" "5.29" "1.64" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707" "10324" "ENSG00000239474" "KLHL41" "hsa:10324; O60662; Q53R42" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5935547261295867920" "False" "Low" "IsMasterProtein" "Q9P2J8" "Zinc finger protein 624 OS=Homo sapiens OX=9606 GN=ZNF624 PE=1 SV=3" "0.074" "False" "1.112" "2" "1" "1" "1" "865" "99.9" "8.88" "2.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "57547" "ENSG00000197566" "ZNF624" "hsa:57547; Q3SY62; Q3SY63; Q6ZN27; Q9P2J8" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8236221211777118383" "False" "Low" "IsMasterProtein" "Q56UN5" "Mitogen-activated protein kinase kinase kinase 19 OS=Homo sapiens OX=9606 GN=MAP3K19 PE=2 SV=1" "0.074" "False" "1.112" "1" "1" "1" "1" "1328" "150.4" "7.05" "0.00" "1" "other metabolic processes" "" "kinase activity;other molecular function" "Pf00069" "80122" "ENSG00000176601" "MAP3K19" "B2RP57; B7ZMH9; E2QRE3; hsa:80122; Q56UN1; Q56UN2; Q56UN3; Q56UN4; Q56UN5; Q8N4E9; Q9H5T2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833474538863443704" "False" "Low" "IsMasterProtein" "Q9NXZ2" "Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens OX=9606 GN=DDX43 PE=1 SV=2" "0.074" "False" "1.109" "2" "1" "1" "1" "648" "72.8" "8.75" "2.27" "1" "" "" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00270, Pf00271" "55510" "ENSG00000080007" "DDX43" "B4E0C8; hsa:55510; Q6NXR1; Q9NXZ2" "" "" "0" "0" "1.014" "0.992" "0.968" "1.073" "0.952" "0.943" "1.026" "0.959" "0.935" "162.8" "165.2" "161.6" "157.6" "174.7" "155.0" "153.6" "167.1" "156.2" "152.2" "" "" "" "" "" "" "" "" "" "" "130.8" "119.2" "128.3" "105.6" "120.8" "116.3" "107.5" "122.0" "156.2" "123.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6754725680768734951" "False" "Low" "IsMasterProtein" "P0C025" "Nucleoside diphosphate-linked moiety X motif 17 OS=Homo sapiens OX=9606 GN=NUDT17 PE=1 SV=2" "0.074" "False" "1.108" "5" "1" "1" "1" "328" "35.9" "6.65" "2.53" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf00293" "200035" "ENSG00000186364" "NUDT17" "hsa:200035; P0C025" "" "TAR syndrome" "1" "0" "0.891" "0.894" "0.882" "0.856" "0.948" "0.791" "0.927" "0.842" "0.881" "112.4" "100.1" "100.5" "99.1" "96.2" "106.5" "88.9" "104.1" "94.6" "99.0" "" "" "" "" "" "" "" "" "" "" "90.3" "72.3" "79.8" "66.4" "66.5" "79.9" "62.2" "76.0" "94.6" "80.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2580685099428473724" "False" "Low" "IsMasterProtein" "Q16772" "Glutathione S-transferase A3 OS=Homo sapiens OX=9606 GN=GSTA3 PE=1 SV=3" "0.075" "False" "1.106" "3" "1" "1" "1" "222" "25.3" "9.20" "0.00" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf02798" "2940" "ENSG00000174156" "GSTA3" "hsa:2940; O43468; Q068V6; Q16772; Q8WWA8; Q9H415" "NFE2L2 regulating anti-oxidant/detoxification enzymes; Glutathione conjugation" "Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8886791885717522515" "False" "Low" "IsMasterProtein" "Q7Z5Y7" "BTB/POZ domain-containing protein KCTD20 OS=Homo sapiens OX=9606 GN=KCTD20 PE=1 SV=1" "0.076" "False" "1.103" "2" "1" "1" "1" "419" "47.5" "5.33" "0.00" "1" "other biological processes" "other cell component" "" "Pf16017" "222658" "ENSG00000112078" "KCTD20" "B4DZD3; B4E2Q3; F5H3T3; hsa:222658; Q5W105; Q69YQ7; Q7Z5Y7; Q8IZ55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1444375086516268996" "False" "Low" "IsMasterProtein" "Q70Z35" "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Homo sapiens OX=9606 GN=PREX2 PE=1 SV=1" "0.076" "False" "1.103" "1" "1" "1" "1" "1606" "182.5" "7.44" "1.82" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00169, Pf00595, Pf00610, Pf00621" "80243" "ENSG00000046889" "PREX2" "B4DFX0; hsa:80243; Q32KL0; Q32KL1; Q6R7Q3; Q6R7Q4; Q70Z35; Q9H805; Q9H961" "Regulation of PTEN stability and activity; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "Melanoma" "5" "0" "1.041" "1.218" "1.310" "1.323" "0.977" "1.102" "1.044" "1.255" "1.333" "38.0" "39.5" "46.3" "49.7" "50.2" "37.1" "41.8" "39.6" "47.7" "50.6" "" "" "" "" "" "" "" "" "" "" "30.5" "28.5" "36.7" "33.3" "34.7" "27.8" "29.3" "29.0" "47.7" "41.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345522786131708725" "False" "Low" "IsMasterProtein" "Q14571" "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2" "0.076" "False" "1.102" "0" "1" "1" "1" "2701" "307.9" "6.43" "2.55" "1" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3709" "ENSG00000123104" "ITPR2" "hsa:3709; O94773; Q14571" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" ""